isoniazid and caffeine

isoniazid has been researched along with caffeine in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	12 (34.29)	18.7374
1990's	3 (8.57)	18.2507
2000's	7 (20.00)	29.6817
2010's	13 (37.14)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Lombardo, F; Obach, RS; Waters, NJ	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Campillo, NE; Guerra, A; Páez, JA	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Léonard, A	1
Desta, Z; Steingruber, M	1
Vesell, ES	1
Nishino, H	1
Greengard, P; Quinn, GP; Reid, MB	1
Cohn, VH; Sieber, SM; Wynn, WT	1
Fabro, S; Sieber, SM	1
Breunig, HL; Broadlick, DE; Comer, JP; Sampson, CB	1
De Fina, V; Duzzi, L; Valsecchi, B	1
Burba, JV	1
Batzias, J; Horbach, GJ; Maas, RF; van Miert, AS; Witkamp, RF; Zweers-Zeilmaker, WM	1
Gibson, GG; Goldfarb, PS; Gray, TJ; Ogg, MS; Tarbit, M; Williams, JM	1
Conte, JE; Duncan, S; Golden, JA; Kipps, J; McKenna, E; McQuitty, M; Zurlinden, E	1
MATERNOWSKA, W	1
JACOBZINER, H; RAYBIN, HW	1
BESSON, H; DEBAY, A	1
Blaszkewicz, M; Golka, K; Hengstler, JG; Ickstadt, K; Selinski, S	1
Aklillu, E; Altman, RB; Boukouvala, S; Hein, DW; Klein, TE; McDonagh, EM	1
Churakov, AV; Drozd, KV; Manin, AN; Perlovich, GL	1
Blaise, C; Gagné, F; Quinn, B	1

Reviews

3 review(s) available for isoniazid and caffeine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Polygenic factors controlling drug response. The Medical clinics of North America, 1974, Volume: 58, Issue:5 Topics: Adult; Animals; Antipyrine; Caffeine; Dicumarol; Environment; Ethanol; Female; Genetic Variation; Half-Life; Halothane; Humans; Isoniazid; Male; Metabolic Clearance Rate; Mice; Middle Aged; Nortriptyline; Pharmaceutical Preparations; Phenylbutazone; Pregnancy; Smoking; Twins	1974
PharmGKB summary: very important pharmacogene information for N-acetyltransferase 2. Pharmacogenetics and genomics, 2014, Volume: 24, Issue:8 Topics: Alleles; Arylamine N-Acetyltransferase; Caffeine; Gene Expression Profiling; Genomics; Genotype; Humans; Hydralazine; Isoenzymes; Isoniazid; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Sulfamethoxazole; Sulfasalazine; Xenobiotics	2014

Trials

1 trial(s) available for isoniazid and caffeine

Article	Year
Effects of gender, AIDS, and acetylator status on intrapulmonary concentrations of isoniazid. Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:8 Topics: Acetylation; Acquired Immunodeficiency Syndrome; Adult; Antitubercular Agents; Body Fluids; Bronchoalveolar Lavage Fluid; Bronchoscopy; Caffeine; Epithelium; Female; Humans; Isoniazid; Lung; Male; Phenotype; Phosphodiesterase Inhibitors; Prospective Studies; Pulmonary Alveoli; Sex Characteristics; Specimen Handling	2002

Article

Year

Effects of gender, AIDS, and acetylator status on intrapulmonary concentrations of isoniazid.

Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:8

Topics: Acetylation; Acquired Immunodeficiency Syndrome; Adult; Antitubercular Agents; Body Fluids; Bronchoalveolar Lavage Fluid; Bronchoscopy; Caffeine; Epithelium; Female; Humans; Isoniazid; Lung; Male; Phenotype; Phosphodiesterase Inhibitors; Prospective Studies; Pulmonary Alveoli; Sex Characteristics; Specimen Handling

2002

Other Studies

31 other study(ies) available for isoniazid and caffeine

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Heritable chromosome aberrations in mammals after exposure to chemicals. Radiation and environmental biophysics, 1976, Mar-30, Volume: 13, Issue:1 Topics: Aflatoxins; Alkylating Agents; Aminoquinolines; Animals; Antimalarials; beta-Aminoethyl Isothiourea; Caffeine; Chromosome Aberrations; Cyclamates; Cysteamine; Dichlorvos; Ethidium; Hycanthone; Insecticides; Isoniazid; Lysergic Acid Diethylamide; Male; Mebendazole; Metals; Mitomycins; Mutagens; Phenylbutazone; Spermatogonia; Spermatozoa; Streptomycin; Translocation, Genetic	1976
Pharmacodynamic interactions between isoniazid and theophylline in mice and rats, and the influence of pyridoxine. Die Pharmazie, 1992, Volume: 47, Issue:7 Topics: Animals; Brain; Caffeine; Convulsants; Drug Interactions; Isoniazid; Male; Mice; Pyridoxine; Rats; Rats, Inbred Strains; Theophylline	1992
[Regional blood flow in the brain. II. Effects of central stimulants, convalsants and a dissociative anesthetic on regional blood flow in the brain]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1973, Volume: 69, Issue:6 Topics: Animals; Blood Pressure; Caffeine; Cats; Central Nervous System Stimulants; Cerebrovascular Circulation; Dibenzylchlorethamine; Electroencephalography; Isoniazid; Ketamine; Methamphetamine; Picrotoxin; Regional Blood Flow; Reserpine; Sulfhydryl Compounds	1973
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism. Molecular pharmacology, 1966, Volume: 2, Issue:4 Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine	1966
The entry of foreign compounds into the thoracic duct lymph of the rat. Xenobiotica; the fate of foreign compounds in biological systems, 1974, Volume: 4, Issue:5 Topics: Acids; Alcohols; Amines; Aniline Compounds; Animals; Anthracenes; Antipyrine; Benzoates; Caffeine; Carbon Radioisotopes; Chromatography, Paper; Chromatography, Thin Layer; Chylomicrons; DDT; Digoxin; Estradiol; Isoniazid; Lymph; Male; Phenanthrenes; Salicylates; Testosterone; Thoracic Duct; Time Factors; Tritium	1974
Identification of drugs in the preimplantation blastocyst and in the plasma, uterine secretion and urine of the pregnant rabbit. The Journal of pharmacology and experimental therapeutics, 1971, Volume: 176, Issue:1 Topics: Animals; Barbiturates; Caffeine; Carbon Isotopes; DDT; Embryo Implantation; Endometrium; Female; Isoniazid; Molecular Weight; Nicotine; Ovum; Pregnancy; Rabbits; Radioisotope Dilution Technique; Theophylline; Thiopental; Tritium; Uterus; Xanthines	1971
Estimation of mean potency and content uniformity of tablets: a new approach. Journal of pharmaceutical sciences, 1970, Volume: 59, Issue:2 Topics: Atropine; Caffeine; Chemistry, Pharmaceutical; Computers; Diethylstilbestrol; Drug Compounding; Drug Tolerance; Isoniazid; Mestranol; Methyltestosterone; Models, Theoretical; Paramethasone; Pharmaceutical Preparations; Phenobarbital; Sulfates; Tablets	1970
[Variations in toxicologic responses of rats in relation to the type of enteric administration]. Bollettino chimico farmaceutico, 1967, Volume: 106, Issue:12 Topics: Animals; Caffeine; Diet; Haloperidol; Isoniazid; Male; Papaverine; Phenylbutazone; Phenylhydrazines; Phosphoric Acids; Rats; Thiazoles	1967
Influence of several drugs on the in vivo and in vitro activity of mammalian hepatic azo-reductase. Canadian journal of biochemistry, 1968, Volume: 46, Issue:4 Topics: Animals; Caffeine; Guanethidine; Guinea Pigs; In Vitro Techniques; Iproniazid; Isoniazid; Liver; Nitrofurantoin; Oxidoreductases; Pentylenetetrazole; Phenobarbital; Phenylbutazone; Phenytoin; Rabbits; Rats; Sulfinpyrazone; Sulfonic Acids; Trimethadione	1968
In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): substrate activities and effects of inducers. Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:11 Topics: Animals; Antipyrine; beta-Naphthoflavone; Biotransformation; Blotting, Western; Caffeine; Cytochrome P-450 Enzyme System; Enzyme Induction; Female; Goats; Isoniazid; Microsomes, Liver; Phenobarbital; Sulfamethazine; Troleandomycin	1996
A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro. Xenobiotica; the fate of foreign compounds in biological systems, 1999, Volume: 29, Issue:3 Topics: Alkaline Phosphatase; beta-Naphthoflavone; Caffeine; Carbamazepine; Carcinoma, Hepatocellular; Clofibrate; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Hormone Antagonists; Humans; Isoniazid; Mifepristone; Mixed Function Oxygenases; Phenobarbital; Phenylbutazone; Phenytoin; Receptors, Glucocorticoid; Recombinant Proteins; Rifampin; Tumor Cells, Cultured; Xenobiotics	1999
[MULTIPLE SENSITIZATION TO ANTIBACTERIAL DRUGS]. Gruzlica (Warsaw, Poland : 1926), 1963, Volume: 31 Topics: Aminosalicylic Acid; Aminosalicylic Acids; Anaphylaxis; Anti-Bacterial Agents; Caffeine; Drug Eruptions; Drug Hypersensitivity; Ethionamide; Histamine H1 Antagonists; Hydrocortisone; Isoniazid; Norepinephrine; Streptomycin; Toxicology; Tuberculosis; Tuberculosis, Pulmonary	1963
ISONIAZID INTOXICATIONS. New York state journal of medicine, 1964, Mar-01, Volume: 64 Topics: Amobarbital; Anti-Bacterial Agents; Caffeine; Child; Ions; Isoniazid; New York; Phenylephrine; Phenytoin; Protein Synthesis Inhibitors; Pyridoxine; Sodium; Sodium, Dietary; Tetracycline; Toxicology	1964
[POTENTIATION BY THEOPHYLLINE AND CAFFEINE OF THE CONVULSANT EFFECTS AND TOXICITY OF ISONIAZID]. Annales pharmaceutiques francaises, 1964, Volume: 22 Topics: Caffeine; Convulsants; Isoniazid; Pharmacology; Rats; Research; Seizures; Theophylline; Toxicology	1964
Refinement of the prediction of N-acetyltransferase 2 (NAT2) phenotypes with respect to enzyme activity and urinary bladder cancer risk. Archives of toxicology, 2013, Volume: 87, Issue:12 Topics: Alleles; Amino Acid Substitution; Arylamine N-Acetyltransferase; Caffeine; Case-Control Studies; Genotype; Isoniazid; Kinetics; Odds Ratio; Phenotype; Phosphodiesterase Inhibitors; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Risk Assessment; Smoking; Urinary Bladder Neoplasms	2013
Drug-drug cocrystals of antituberculous 4-aminosalicylic acid: Screening, crystal structures, thermochemical and solubility studies. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2017, Mar-01, Volume: 99 Topics: Aminosalicylic Acid; Antitubercular Agents; Caffeine; Crystallization; Crystallography, X-Ray; Drug Stability; Isoniazid; Models, Molecular; Niacinamide; Powder Diffraction; Pyrazinamide; Solubility; Theophylline; X-Ray Diffraction	2017
Evaluation of the acute, chronic and teratogenic effects of a mixture of eleven pharmaceuticals on the cnidarian, Hydra attenuata. The Science of the total environment, 2009, Jan-15, Volume: 407, Issue:3 Topics: Analgesics; Animal Feed; Animals; Anti-Bacterial Agents; Artemia; Caffeine; Feeding Behavior; Hydra; Lethal Dose 50; Regeneration; Teratogens	2009