isomethyleugenol has been researched along with quinazolines in 55 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (14.55) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (12.73) | 29.6817 |
| 2010's | 36 (65.45) | 24.3611 |
| 2020's | 4 (7.27) | 2.80 |
| Authors | Studies |
|---|---|
| Bertini, R; Brancia, E; Brasili, L; Giardinà, D; Melchiorre, C | 1 |
| Lakshmanan, MR; Narindrasorasak, S | 1 |
| Advani, BG; Rajappa, S | 1 |
| Hutchison, DJ; Philips, FS; Sirotnak, FM; Sodergren, JE | 1 |
| Bogentoft, C; Danielsson, B; Ericsson, O; Lindberg, C | 1 |
| Hagen, HE; Roth, HJ | 1 |
| Hayashi, E; Higashino, T; Tomisaka, S | 1 |
| Marzo, A; Quadro, G; Treffner, E | 1 |
| Comins, DL; Goehring, RR; Zheng, X | 1 |
| Gaiger, A; Grunt, TW; Kainz, B; Puckmair, K; Tomek, K | 1 |
| Borioni, A; Del Giudice, MR; Ferretti, R; Mustazza, C; Rodomonte, A; Sbraccia, M; Sestili, I | 1 |
| Thomas, NR | 1 |
| Cobo, J; Cruz, S; de la Torre, JM; Glidewell, C; Low, JN; Quiroga, J | 1 |
| August, EM; Hickey, ER; Homon, CA; Jenuwein, T; Kelly, TA; Kowalski, JA; Kubicek, S; Mechtler, K; O'Sullivan, RJ; Rea, S; Teodoro, ML; Zhang, Q | 1 |
| Alagarsamy, V; Kavitha, K; Meena, S; Rajesh, R; Rupeshkumar, M; Shankar, D; Siddiqui, AA | 1 |
| Müller, AM; Obier, N | 1 |
| Agarwal, N; Ahluwalia, MS; Barnett, GH; Brewer, CJ; Elson, P; Peereboom, DM; Shepard, DR; Stevens, GH; Suh, JH; Toms, SA; Vogelbaum, MA; Weil, RJ | 1 |
| Cho, S; Jeong, YS; Kang, YK; Ko, Y; Park, JS | 1 |
| Allali-Hassani, A; Quinn, AM; Simeonov, A; Vedadi, M | 1 |
| Bertran-Alamillo, J; Cardenal, F; Cobo, M; Garrido, P; Isla, D; Lianes, P; Manegold, C; Massuti, B; Molina, MA; Moran, T; Ramirez, JL; Rosell, R; Salazar, F; Sanchez, JJ; Sanchez, JM; Sanchez-Ronco, M; Stahel, R; Taron, M; Trigo, JM | 1 |
| Gao, M; Lola, CM; Miller, KD; Sledge, GW; Wang, M; Zheng, QH | 1 |
| Igarashi, Y; Ito, A; Kawasaki, H; Shimazu, T; Shin-ya, K; Shinkai, Y; Tachibana, M; Takagi, M; Takahashi, M; Takemoto, Y; Yoshida, M | 1 |
| Davis, RL; Deramus, T; Franklin, AV; Gupta-Agarwal, S; Lubin, FD; McMahon, LL; Wheelock, M | 1 |
| Cabot, RA; Johnson, CM; Park, KE | 1 |
| Fuchter, MJ; Malmquist, NA; Mecheri, S; Moss, TA; Scherf, A | 1 |
| Appadurai, DA; Manning, J; May, JM; Mitchell, B; Nganga, V; Pierce, LJ; Shakya, A; Spangrude, GJ; Swanson, PC; Tantin, D; Wang, H | 1 |
| Chen, Y; Fu, S; He, Y; Jiang, H; Li, H; Lin, Q; Shou, J; Sun, S; Wang, Y; Yu, H; Yu, Y | 1 |
| Abrams, JS; Conley, BA; Freidlin, B; Korn, EL; McShane, LM; Polley, MY | 1 |
| Itoi, F; Li, C; Sato, E; Tanemura, K; Terashita, Y; Tokoro, M; Wakayama, S; Wakayama, T; Yamagata, K | 1 |
| Imai, K; Ochiai, K; Suzuki, N; Tsuda, H; Yang, P; Zhao, N | 1 |
| Asara, JM; Choi, JH; Cui, H; Ding, HF; Ding, J; Dong, Z; Huang, S; Li, T; Wang, X; Yang, L; Zha, Y; Zhao, E | 1 |
| An, XR; Fu, L; Hou, J; Yan, FX | 1 |
| Feng, D; Hu, Q; Li, H; Ma, H; Su, Y; Tao, H; Wang, X; Zhang, C | 1 |
| Casey, PJ; Go, ML; Guo, D; Lau, HY; Ramanujulu, PM; Wang, M; Wirawan, M; Yang, T | 1 |
| Bae, KS; Jung, JA; Lim, HS; Noh, YH; Song, TH | 1 |
| Fan, JD; He, YL; Lei, PJ; Li, LY; Li, S; Liu, H; Wang, X; Wang, ZN; Wei, G; Wu, M; Zhang, X; Zheng, JY | 1 |
| Geutskens, SB; Goedhart, M; Haasnoot, GW; Miggelbrink, XM; Muggen, AF; van den Elsen, PJ; van Eggermond, MC; van Zwet, E; Wierda, RJ | 1 |
| Arihiro, K; Doi, S; Doi, T; Irifuku, T; Kohno, N; Masaki, T; Nakashima, A; Sasaki, K; Ueno, T; Yamada, K | 1 |
| Chao, SB; Huang, XJ; Lin, F; Liu, HL; Ma, XS; Meng, TG; Qin, L; Schatten, H; Sun, QY; Wang, XG; Zhu, CC | 1 |
| Berardino, BG; Caramelo, JJ; Enriqué Steinberg, JH; Fiszbein, A; Giono, LE; Kornblihtt, AR; Pietrasanta, LI; Quaglino, A; Rossi, M; Schor, IE; Sigaut, L; Srebrow, A; von Bilderling, C | 1 |
| Chen, C; Feng, W; He, M; Li, M; Liu, C; Lu, Y; Pi, H; Yang, L; Yu, Z; Zhang, L; Zhang, Y; Zhong, M; Zhou, Z | 1 |
| Aburaya, S; Aoki, W; Inaoka, H; Masuya, T; Miyoshi, H; Murai, M | 1 |
| Huang, R; Huang, Y; Jiang, X; Li, M; Yang, X; Yao, J; Yu, M; Zheng, F | 1 |
| Abdelnabi, R; Delang, L; Leyssen, P; Near, KE; Neyts, J; Staveness, D; Wender, PA | 1 |
| Chang, CC; Chang, J; Chang, YC; Chang, YF; Cheng, CC; Ho, AS; Huang, L; Huang, SC; Lim, KH; Lin, HC; Wu, CW | 1 |
| Abdullah, LN; Chow, EK; Ho, JC; Jha, S; Kato, H; Lee, KL; Pang, QY; Poellinger, L; Ueda, J; Yang, H | 1 |
| Jin, J; Kosowan, J; Leung, L; Li, YX; Oh, G; Petronis, A; Samsom, J; Wang, DY; Wong, AHC; Xiong, Y; Zhang, KL | 1 |
| Abele, S; Almeida, S; Marti, R; Tortoioli, S; Vanoli, E | 1 |
| Chatterjee, M; Dworak, N; Jividen, K; Johnson, IG; Kelley, JB; Makosa, D; Paschal, BM; Simke, WC; Snow, C; Yang, CS | 1 |
| Burbulla, LF; Jeon, S; Jiang, W; Krainc, D; Oevel, K; Silverman, RB; Ysselstein, D; Zheng, J | 1 |
| Greengard, P; Hu, Z; Lin, L; Liu, T; Ma, K; Matas, E; Seo, JS; Wang, J; Wang, ZJ; Yan, Z; Yang, F; Zhang, F; Zhong, P | 1 |
| Cui, Y; Dai, M; Hu, Y; Kong, W; Wang, X; Wu, H; Wu, J; Yu, B; Yu, X; Zhang, H; Zheng, Y | 1 |
| Charles, MRC; Coumar, MS; Dhayalan, A; Hsieh, HP; Lin, SY; Mahesh, A | 1 |
| Hong, S; Wiley, JW; Zheng, G; Zhu, S; Zong, Y | 1 |
| Nagaraja, SS; Nagarajan, D; Subramanian, U | 1 |
2 trial(s) available for isomethyleugenol and quinazolines
| Article | Year |
|---|---|
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Disease-Free Survival; DNA Modification Methylases; DNA Repair Enzymes; Erlotinib Hydrochloride; Female; Glioblastoma; Humans; Karnofsky Performance Status; Magnetic Resonance Imaging; Male; Methylation; Middle Aged; Protein Kinase Inhibitors; Quinazolines; Radiotherapy; Temozolomide; Tumor Suppressor Proteins; Young Adult | 2010 |
Population pharmacokinetics of HM781-36 (poziotinib), pan-human EGF receptor (HER) inhibitor, and its two metabolites in patients with advanced solid malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biotransformation; Dose-Response Relationship, Drug; Drugs, Investigational; ErbB Receptors; Female; Food-Drug Interactions; Half-Life; Humans; Hydroxylation; Intestinal Absorption; Male; Metabolic Clearance Rate; Methylation; Middle Aged; Models, Biological; Neoplasms; Quinazolines; Tablets | 2015 |
53 other study(ies) available for isomethyleugenol and quinazolines
| Article | Year |
|---|---|
Structure-activity relationships for prazosin and WB 4101 analogues as alpha 1-adrenoreceptor antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Chemical Phenomena; Chemistry; Dioxanes; Dioxins; Male; Methylation; Prazosin; Quinazolines; Rats; Receptors, Adrenergic, alpha; Structure-Activity Relationship; Vas Deferens | 1985 |
Conversion of retinyl methyl ether into retinol in the rat in vitro.
Topics: Aluminum; Animals; Edetic Acid; Enzyme Activation; Ethers; Intestinal Mucosa; Kinetics; Lithium; Liver; Magnesium; Male; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Models, Chemical; NADP; Oxygenases; Pteridines; Quinazolines; Rats; Subcellular Fractions; Tritium; Vitamin A | 1972 |
Conformational studies on tricyclic quinazolones derived from cyclodipeptides incorporating sarcosine.
Topics: Cyclization; Dipeptides; Methylation; Molecular Conformation; Peptides, Cyclic; Quinazolines; Sarcosine | 1974 |
Uptake of methotrexate, aminopterin, and methasquin and inhibition of dihydrofolate reductase and of DNA synthesis in mouse small intestine.
Topics: Aminopterin; Animals; Deoxyuridine; DNA; Dose-Response Relationship, Drug; Folic Acid Antagonists; Injections, Intravenous; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Methylation; Mice; Quinazolines | 1973 |
Methaqualone metabolites. Synthesis of eight phenolic monohydroxy derivatives of methaqualone.
Topics: Acetylation; Aniline Compounds; Anisoles; Cresols; Hydroxylation; Methaqualone; Methylation; ortho-Aminobenzoates; Quinazolines; Time Factors; Toluidines | 1973 |
[Aminomethylation of enamines of cyclic beta-dicarbonyl compounds].
Topics: Amines; Benzyl Compounds; Chemical Phenomena; Chemistry; Chlorides; Formaldehyde; Methods; Methylation; Piperidines; Quinazolines; Resorcinols; Spectrum Analysis | 1971 |
[Methylation of 4-aminoquinazoline 3-oxide with diazomethane].
Topics: Methane; Methylation; Quinazolines | 1967 |
Gas-liquid chromatographic evaluation of fenquizone in biological samples for pharmacokinetic investigations.
Topics: Chromatography, Gas; Humans; Kinetics; Mass Spectrometry; Methylation; Quinazolines; Time Factors | 1983 |
Total synthesis of the putative structure of the lupin alkaloid plumerinine.
Topics: Alkaloids; Asia; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylation; Models, Molecular; Oxidation-Reduction; Plants, Medicinal; Quinazolines; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet | 2002 |
An EGF receptor inhibitor induces RAR-beta expression in breast and ovarian cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; ErbB Receptors; Female; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Humans; Methylation; Ovarian Neoplasms; Promoter Regions, Genetic; Quinazolines; Receptor, ErbB-2; Receptors, Retinoic Acid; RNA, Messenger | 2005 |
Synthesis and evaluation as NOP ligands of some spiro[piperidine-4,2'(1'H)-quinazolin]-4'(3'H)-ones and spiro[piperidine-4,5'(6'H)-[1,2,4]triazolo[1,5-c]quinazolines].
Topics: Benzyl Compounds; Cell Line; Cell Membrane; Cyclohexanes; Drug Design; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Methylation; Models, Molecular; Molecular Conformation; Nociceptin Receptor; Quinazolines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spiro Compounds; Structure-Activity Relationship; Triazoles | 2006 |
Histone post-translational modification: from discovery to the clinic.
Topics: Acetylation; Animals; Antineoplastic Agents; Aurora Kinases; Benzamides; Clinical Trials as Topic; Depsipeptides; Hematologic Neoplasms; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Protein Conformation; Protein Kinase Inhibitors; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Quinazolines | 2006 |
Four 2-aryl-8,8-dimethyl-6,7,8,9-tetrahydropyrazolo[2,3-a]quinazolin-6-ones: isolated molecules, hydrogen-bonded dimers, and pi-stacked chains of hydrogen-bonded dimers.
Topics: Crystallography, X-Ray; Dimerization; Hydrogen Bonding; Methylation; Models, Molecular; Molecular Structure; Quinazolines; Stereoisomerism | 2006 |
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
Topics: Animals; Azepines; Cell Line; Enzyme Inhibitors; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Promoter Regions, Genetic; Protein Methyltransferases; Quinazolines | 2007 |
Synthesis and pharmacological investigation of novel 4-(2-methylphenyl)-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H(1)-antihistaminic agents.
Topics: Animals; Central Nervous System; Guinea Pigs; Histamine H1 Antagonists; Male; Methylation; Molecular Structure; Quinazolines; Structure-Activity Relationship; Triazoles | 2008 |
Chromatin flow cytometry identifies changes in epigenetic cell states.
Topics: Acetylation; Animals; Azepines; Cell Differentiation; Cells, Cultured; Chromatin; Embryonic Stem Cells; Epigenesis, Genetic; Flow Cytometry; Histone Deacetylase Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Hydroxamic Acids; Methylation; Mice; Quinazolines | 2010 |
Phosphorylation of serine-10 of histone H3 shields modified lysine-9 selectively during mitosis.
Topics: Animals; Aurora Kinase B; Benzamides; Cell Cycle; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Female; Histones; Lysine; Male; Methylation; Mice; Mitosis; NIH 3T3 Cells; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Serine | 2010 |
A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors.
Topics: Azepines; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Humans; Luminescent Measurements; Methylation; Models, Theoretical; Quinazolines | 2010 |
First-line therapy and methylation status of CHFR in serum influence outcome to chemotherapy versus EGFR tyrosine kinase inhibitors as second-line therapy in stage IV non-small-cell lung cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cisplatin; ErbB Receptors; Erlotinib Hydrochloride; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Lung Neoplasms; Male; Methylation; Middle Aged; Mutation; Neoplasm Proteins; Neoplasm Staging; Poly-ADP-Ribose Binding Proteins; Protein Kinase Inhibitors; Quinazolines; Survival Analysis; Ubiquitin-Protein Ligases | 2011 |
Radiosynthesis of [11C]Vandetanib and [11C]chloro-Vandetanib as new potential PET agents for imaging of VEGFR in cancer.
Topics: Carbon Radioisotopes; Chlorine; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Neoplasms; Piperidines; Positron-Emission Tomography; Quinazolines; Radiopharmaceuticals; Receptors, Vascular Endothelial Growth Factor | 2011 |
Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines.
Topics: Azepines; Crystallization; Disulfides; Drug Design; Enzyme Inhibitors; Gliotoxin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Indole Alkaloids; Methylation; Piperazines; Quinazolines | 2012 |
G9a/GLP histone lysine dimethyltransferase complex activity in the hippocampus and the entorhinal cortex is required for gene activation and silencing during memory consolidation.
Topics: Analysis of Variance; Animals; Azepines; Brain-Derived Neurotrophic Factor; Chromatin Immunoprecipitation; Conditioning, Psychological; Cues; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Electric Stimulation; Entorhinal Cortex; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Fear; Gene Silencing; Hippocampus; Histone-Lysine N-Methyltransferase; Histones; In Vitro Techniques; Long-Term Potentiation; Male; Memory; Methylation; Patch-Clamp Techniques; Polymers; Proto-Oncogene Proteins c-fyn; Quinazolines; Rats; Rats, Sprague-Dawley; Transcriptional Activation | 2012 |
IVMBIX-01294, an inhibitor of the histone methyltransferase EHMT2, disrupts histone H3 lysine 9 (H3K9) dimethylation in the cleavage-stage porcine embryo.
Topics: Animals; Azepines; Cleavage Stage, Ovum; Dose-Response Relationship, Drug; Embryo Culture Techniques; Embryo Transfer; Embryo, Mammalian; Embryonic Development; Enzyme Inhibitors; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Pregnancy; Pregnancy Rate; Quinazolines; RNA, Messenger; Swine; Time Factors; Transcription, Genetic | 2012 |
Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Antimalarials; Azepines; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Erythrocytes; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Life Cycle Stages; Lysine; Malaria; Methylation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Parasitemia; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Sequence Homology, Amino Acid | 2012 |
Vitamin C promotes maturation of T-cells.
Topics: Animals; Ascorbic Acid; Azepines; Cells, Cultured; Culture Media; Epigenesis, Genetic; Gene Expression; Gene Rearrangement, T-Lymphocyte; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Immunologic Factors; Methylation; Mice; Mice, Inbred C57BL; Phthalimides; Protein Processing, Post-Translational; Quinazolines; Receptors, Antigen, T-Cell; T-Lymphocytes; Tryptophan | 2013 |
Inhibition of H3K9 methyltransferases G9a/GLP prevents ototoxicity and ongoing hair cell death.
Topics: Animals; Anti-Bacterial Agents; Apoptosis; Azepines; Cells, Cultured; Cochlea; Hair Cells, Auditory; Histone-Lysine N-Methyltransferase; Histones; Methylation; Mice; Mice, Inbred C57BL; Models, Animal; Neomycin; Organ of Corti; Quinazolines | 2013 |
Statistical and practical considerations for clinical evaluation of predictive biomarkers.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Dacarbazine; DNA Modification Methylases; DNA Repair Enzymes; ErbB Receptors; Gefitinib; Glioblastoma; Humans; Indazoles; Interleukin-6; Kidney Neoplasms; Lung Neoplasms; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Precision Medicine; Predictive Value of Tests; Pyrimidines; Quinazolines; Radiotherapy, Adjuvant; Randomized Controlled Trials as Topic; Sample Size; Sulfonamides; Temozolomide; Tumor Suppressor Proteins | 2013 |
Latrunculin A treatment prevents abnormal chromosome segregation for successful development of cloned embryos.
Topics: Actins; Animals; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Chromosome Segregation; Cloning, Organism; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Fertilization in Vitro; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nuclear Transfer Techniques; Oocytes; Quinazolines; Thiazolidines | 2013 |
BIX01294 suppresses osteoclast differentiation on mouse macrophage-like Raw264.7 cells.
Topics: Animals; Azepines; Cell Differentiation; Cell Line; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Macrophages; Methylation; Mice; NFATC Transcription Factors; Osteoclasts; Quinazolines; RANK Ligand | 2013 |
The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation.
Topics: Animals; Autophagy; Azepines; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Epigenomics; Glycine; HeLa Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Microtubule-Associated Proteins; Quinazolines; Ribosomes; Serine; Transcription, Genetic | 2013 |
Effects of the histone methyltransferase inhibitor UNC0638 on histone H3K9 dimethylation of cultured ovine somatic cells and development of resulting early cloned embryos.
Topics: Animals; Cloning, Organism; Embryo, Mammalian; Embryonic Development; Fibroblasts; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Methylation; Quinazolines; Sheep | 2014 |
Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
Topics: AC133 Antigen; Antigens, CD; Azepines; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioma; Glycoproteins; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplastic Stem Cells; Peptides; Promoter Regions, Genetic; Quinazolines; Signal Transduction; SOXB1 Transcription Factors; Transfection | 2014 |
An improved isoprenylcysteine carboxylmethyltransferase inhibitor induces cancer cell death and attenuates tumor growth in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; ErbB Receptors; Female; Gefitinib; Heterografts; Humans; Indoles; Lamin Type A; Liver Neoplasms; Methylation; Mice, SCID; Oncogene Protein p21(ras); Protein Methyltransferases; Protein Prenylation; Pyrimidines; Quinazolines | 2014 |
The selective activation of p53 target genes regulated by SMYD2 in BIX-01294 induced autophagy-related cell death.
Topics: Apoptosis; Autophagy; Autophagy-Related Proteins; Azepines; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Cysteine Endopeptidases; HCT116 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Membrane Proteins; Methylation; Microtubule-Associated Proteins; Quinazolines; RNA Interference; RNA, Small Interfering; Sirolimus; Transcriptome; Tumor Suppressor Protein p53; Vesicular Transport Proteins | 2015 |
A role for KMT1c in monocyte to dendritic cell differentiation: Epigenetic regulation of monocyte differentiation.
Topics: Acetylation; Adenosine; Azepines; Cell Adhesion Molecules; Cell Differentiation; Chromatin; Chromatin Assembly and Disassembly; Dendritic Cells; Epigenesis, Genetic; Gene Expression Profiling; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Lectins, C-Type; Methylation; Monocytes; Primary Cell Culture; Quinazolines; Receptors, Cell Surface; Signal Transduction; Transcription, Genetic | 2015 |
Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression.
Topics: Actins; Animals; Antibodies, Neutralizing; Azepines; Cell Line; Enzyme Inhibitors; Fibroblasts; Fibronectins; Fibrosis; Glomerulonephritis, IGA; Glucuronidase; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Kidney; Klotho Proteins; Lysine; Male; Methylation; Mice; Quinazolines; Rats; RNA, Messenger; RNA, Small Interfering; Transforming Growth Factor beta1; Ureteral Obstruction | 2016 |
The Dynamics and Regulatory Mechanism of Pronuclear H3k9me2 Asymmetry in Mouse Zygotes.
Topics: Animals; Azepines; Cell Nucleus; Fertilization in Vitro; Histone-Lysine N-Methyltransferase; Histones; Kruppel-Like Transcription Factors; Lysine; Methylation; Mice; Microinjections; Models, Biological; Nerve Tissue Proteins; Quinazolines; RNA, Small Interfering; Zygote | 2015 |
Alternative Splicing of G9a Regulates Neuronal Differentiation.
Topics: Alternative Splicing; Animals; Azepines; Brain; Cell Differentiation; Cell Line; Cell Nucleus; Exons; Fluorescence Resonance Energy Transfer; Genes, Reporter; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Neurons; Protein Isoforms; Quinazolines; Real-Time Polymerase Chain Reaction; RNA Interference; RNA Precursors; RNA, Small Interfering; Tretinoin | 2016 |
G9a-mediated histone methylation regulates cadmium-induced male fertility damage in pubertal mice.
Topics: Age Factors; Animals; Apoptosis; Apoptosis Regulatory Proteins; Azepines; Blotting, Western; Cadmium Chloride; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Fertility; Fluorescent Antibody Technique; Histone-Lysine N-Methyltransferase; Histones; In Situ Nick-End Labeling; Infertility, Male; Litter Size; Male; Methylation; Mice, Inbred C57BL; Quinazolines; Sexual Development; Sperm Count; Testis; Time Factors | 2016 |
Specific Methylation of Asp160 (49 kDa subunit) Located inside the Quinone Binding Cavity of Bovine Mitochondrial Complex I.
Topics: Animals; Aspartic Acid; Binding Sites; Catalytic Domain; Cattle; Electron Transport; Electron Transport Complex I; Enzyme Inhibitors; Ligands; Methylation; Mitochondria, Heart; Protein Conformation; Protein Subunits; Quinazolines; Quinones; Tosyl Compounds | 2016 |
Beneficial effects of diazepin-quinazolin-amine derivative (BIX-01294) on preimplantation development and molecular characteristics of cloned mouse embryos.
Topics: Animals; Azepines; Blastocyst; Cloning, Organism; CpG Islands; DNA Methylation; Ectogenesis; Embryo, Mammalian; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; GRB10 Adaptor Protein; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Mice; Nuclear Transfer Techniques; Parthenogenesis; Protein Processing, Post-Translational; Quinazolines | 2017 |
Comparative analysis of the anti-chikungunya virus activity of novel bryostatin analogs confirms the existence of a PKC-independent mechanism.
Topics: Acetylation; Animals; Antiviral Agents; Bryostatins; Carbazoles; Cell Line; Chikungunya virus; Chlorocebus aethiops; Drug Design; Drug Synergism; Gene Expression Regulation, Viral; Humans; Isoenzymes; Kinetics; Methylation; Protein Kinase C; Protein Kinase Inhibitors; Pyrroles; Quinazolines; Semliki forest virus; Sindbis Virus; Viral Proteins; Virus Replication | 2016 |
YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells.
Topics: Afatinib; Antineoplastic Agents; Cell Line, Tumor; Drug Evaluation, Preclinical; ErbB Receptors; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Imidazoles; Lung Neoplasms; Methylation; Naphthoquinones; Octamer Transcription Factor-3; Phosphorylation; Quinazolines; RNA, Messenger | 2017 |
Inhibition of the H3K9 methyltransferase G9A attenuates oncogenicity and activates the hypoxia signaling pathway.
Topics: Apoptosis; Azepines; Cell Cycle; Cell Hypoxia; Cell Movement; Cell Proliferation; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; MCF-7 Cells; Methylation; Neoplasms; Oncogenes; Prognosis; Quinazolines; Signal Transduction | 2017 |
Inhibition of the G9a/GLP histone methyltransferase complex modulates anxiety-related behavior in mice.
Topics: Animals; Anti-Anxiety Agents; Diazepam; Dose-Response Relationship, Drug; Epigenesis, Genetic; Female; Histone-Lysine N-Methyltransferase; Histones; Indoles; Male; Methylation; Mice, Inbred C57BL; Protein Processing, Post-Translational; Quinazolines; Spiro Compounds; Venlafaxine Hydrochloride | 2018 |
One-Pot Synthesis of Trifluoromethylated Quinazolin-4(3 H)-ones with Trifluoroacetic Acid as CF
Topics: Catalysis; Chemistry Techniques, Synthetic; Methylation; Quinazolines; Trifluoroacetic Acid | 2018 |
A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling.
Topics: Active Transport, Cell Nucleus; Azepines; Chromatin; DNA Damage; Fibroblasts; Histones; Humans; Interphase; Lamin Type A; Lysine; Methylation; Nuclear Lamina; Progeria; Quinazolines; ran GTP-Binding Protein; Signal Transduction | 2019 |
Conversion of Quinazoline Modulators from Inhibitors to Activators of β-Glucocerebrosidase.
Topics: Dopaminergic Neurons; Enzyme Activators; Enzyme Inhibitors; Gaucher Disease; Glucosylceramidase; Humans; Methylation; Parkinson Disease; Quinazolines; Structure-Activity Relationship | 2019 |
Amelioration of autism-like social deficits by targeting histone methyltransferases EHMT1/2 in Shank3-deficient mice.
Topics: Animals; Autistic Disorder; Disease Models, Animal; Female; Haploinsufficiency; Histone-Lysine N-Methyltransferase; Histones; Male; Methylation; Mice; Microfilament Proteins; Nerve Tissue Proteins; Prefrontal Cortex; Quinazolines | 2020 |
G9a and histone deacetylases are crucial for Snail2-mediated E-cadherin repression and metastasis in hepatocellular carcinoma.
Topics: Acetylation; Animals; Azepines; Cadherins; Carcinoma, Hepatocellular; Cell Movement; Disease Progression; Down-Regulation; Epigenesis, Genetic; Epithelial-Mesenchymal Transition; Female; Histocompatibility Antigens; Histone Deacetylase Inhibitors; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Humans; Hydroxamic Acids; Liver; Liver Neoplasms; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Quinazolines; Snail Family Transcription Factors; Transcription, Genetic; Transforming Growth Factor beta | 2019 |
Identification of novel quinoline inhibitor for EHMT2/G9a through virtual screening.
Topics: Azepines; Catalytic Domain; Databases, Chemical; Enzyme Inhibitors; HEK293 Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Protein Binding; Quinazolines; Quinolines | 2020 |
Histone H3K9 methylation regulates chronic stress and IL-6-induced colon epithelial permeability and visceral pain.
Topics: Animals; Caco-2 Cells; Chronic Disease; Colon; Epithelium; Histones; Humans; Interleukin-6; Male; Methylation; Permeability; Quinazolines; Rats; Rats, Sprague-Dawley; Stress, Psychological; Visceral Pain | 2020 |
Radiation-induced H3K9 methylation on E-cadherin promoter mediated by ROS/Snail axis : Role of G9a signaling during lung epithelial-mesenchymal transition.
Topics: Azepines; Cadherins; Cell Line; Cell Movement; Cell Survival; Epithelial Cells; Epithelial-Mesenchymal Transition; Glycogen Synthase Kinase 3 beta; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung; Methylation; Promoter Regions, Genetic; Quinazolines; Reactive Oxygen Species; Signal Transduction; Snail Family Transcription Factors; X-Rays | 2021 |