isomethyleugenol has been researched along with morphine in 56 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (62.50) | 18.7374 |
| 1990's | 5 (8.93) | 18.2507 |
| 2000's | 4 (7.14) | 29.6817 |
| 2010's | 11 (19.64) | 24.3611 |
| 2020's | 1 (1.79) | 2.80 |
| Authors | Studies |
|---|---|
| DeGraw, JI; Lawson, JA | 1 |
| Barber, RB; Rapoport, H | 1 |
| Abe, T; Ando, S; Handa, S; Kasama, T; Kon, K; Rokukawa, C; Taki, T | 1 |
| Bochner, F; Chen, ZR; Irvine, RJ; Somogyi, AA | 1 |
| Blanck, A; Hansson, T; Näslund, B; Rane, A | 1 |
| Carruthers, RA; Cashmore, GC; Feeney, J; Feizi, T; Hounsell, EF; Kane, DP; Lawson, AM; Stoll, MS | 1 |
| Capon, C; Fournet, B; Leroy, Y; Montreuil, J; Ricart, G; Strecker, G; Wieruszeski, JM | 1 |
| Endo, T; Iwaki, Y; Kobata, A; Kuroki, M; Matsuoka, Y; Totani, K; Yamashita, K | 1 |
| Baba, Y; Ban, M; Fujimura, H; Hori, M; Imai, E; Iwata, N; Morita, T; Niwa, M; Nozaki, M; Suzuki, Y | 1 |
| Larson, G | 1 |
| Her, GR; Kuei, J; Reinhold, VN | 1 |
| Brossi, A; Dumont, R; Newman, AH; Rice, KC; Toome, V; Wegrzynski, B | 1 |
| Davis, WM; Khalsa, JH | 1 |
| Westfall, TC | 1 |
| Estabrook, RW; Franklin, MR; Hildebrandt, AG | 1 |
| Fennessy, MR; Gaff, GA; Heimans, RL | 1 |
| Chaudhuri, RK; Ghosal, S; Sharma, PV | 1 |
| Gomaa, ZS; Larson, DL; Portoghese, PS | 1 |
| Cimbura, G; Kofoed, J | 1 |
| Ahtee, L; Boullin, DJ; Paasonen, MK; Saarnivaara, L | 1 |
| Way, EL | 1 |
| Gillete, JR; Hamrick, ME; Stripp, B | 1 |
| Bentley, KW; Lewis, JW; Smith, AC | 1 |
| Kato, R; Onoda, KI; Takanaka, A | 1 |
| Bhatnagar, SP | 1 |
| Hanna, PE; Mertes, MP; Miller, DD; Ramsey, AA | 1 |
| Woods, LA; Yeh, SY | 1 |
| Davies, DS; Gigon, PL; Gillette, JR | 1 |
| Axelrod, J | 1 |
| Månsson, JE; Nilsson, O; Svennerholm, L; Tibblin, E | 1 |
| Fukushima, K; Kanai, M; Kobata, A; Kuroki, M; Matsuoka, Y; Ohkura, T; Yamashita, K | 1 |
| Asmussen, J; Broen Christensen, C; Brøsen, K; Hofmann, U; Ingwersen, SH; Mikus, G; Nielsen, F; Sindrup, SH | 1 |
| Bechtel, PR; Bechtel, Y; Berard, M; Haffen, E; Masuyer, C; Paintaud, G | 1 |
| Ducharme, J; Morin, PE; Projean, D; Tu, TM | 1 |
| SANFILIPPO, G | 1 |
| MANNERING, GJ; TAKEMORI, AE | 1 |
| KLEINSCHMIDT, G | 1 |
| ELISON, C; ELLIOTT, HW; LAURSEN, R; RAPOPORT, H | 1 |
| CLOUET, DH; KURZMAN, M; RATNER, M | 1 |
| CLOUET, DH | 1 |
| ELISON, C; ELLIOTT, HW | 2 |
| Boyd, MR; Chinta, SJ; Kommaddi, RP; Mori, T; Pai, HV; Ravindranath, V | 1 |
| Bidlack, JM; Csutoras, C; Neumeyer, JL; Zhang, A | 1 |
| Facchini, PJ; Hagel, JM | 1 |
| Bruner, SD; Dimise, EJ | 1 |
| Kok, GB; Scammells, PJ | 1 |
| Fan, J; Gaehle, GG; Kharasch, ED; Li, S; Mach, RH; Meissner, K; Tu, Z | 1 |
| Chien, CC; Feng, YP; Lee, SO; Lin, YS; Shen, CH; Tsai, RY; Tsai, WY; Wong, CS | 1 |
| Cao, JL; Peng, YN; Tang, LH; Wang, Y; Yan, M; Yu, LN; Zhou, XL | 1 |
| Alvarado Rojas, M; Guengerich, FP; Kanamori, T; Kramlinger, VM | 1 |
| Clarke, A; Deth, R; Lopez-Toledano, M; Trivedi, M; Zhang, Y | 1 |
| Borowski, T; Kluza, A; Kot, E; Kurpiewska, K; Niedzialkowska, E; Porebski, PJ; Quesne, M; Wojdyla, Z | 1 |
| Akbarali, HI; Dewey, WL; Komla, E; Obeng, S; Selley, DE; Stevens, DL; Wang, H; Zhang, Y; Zheng, Y | 1 |
| Chen, M; Hao, W; Zhang, X | 1 |
| Kuo, KC; Suen, JL; Wu, PL; Yang, CH; Yang, SN; Yang, YSH | 1 |
1 review(s) available for isomethyleugenol and morphine
| Article | Year |
|---|---|
II. Distribution and metabolism of morphine and its surrogates.
Topics: Alkylation; Analgesics; Biotransformation; Drug Tolerance; Methylation; Morphine | 1968 |
1 trial(s) available for isomethyleugenol and morphine
| Article | Year |
|---|---|
Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Blood-Brain Barrier; Central Nervous System; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Gas Chromatography-Mass Spectrometry; Humans; Liver; Male; Methylation; Middle Aged; Mixed Function Oxygenases; Morphine; Quinidine; Sparteine | 1996 |
54 other study(ies) available for isomethyleugenol and morphine
| Article | Year |
|---|---|
An improved method for O-demethylation of codeine.
Topics: Codeine; Methylation; Morphine; Sulfhydryl Compounds; Temperature; Thebaine | 1977 |
Synthesis of thebaine and oripavine from codeine and morphine.
Topics: Codeine; Methods; Methylation; Morphine; Oxidation-Reduction; Thebaine | 1975 |
Human meconium gangliosides. Characterization of a novel I-type ganglioside with the NeuAc alpha 2-6Gal structure.
Topics: Amino Sugars; Carbohydrate Sequence; Carbohydrates; Chromatography, Thin Layer; Fatty Acids; Gangliosides; Humans; Magnetic Resonance Spectroscopy; Meconium; Methylation; Molecular Sequence Data; Spectrometry, Mass, Fast Atom Bombardment | 1992 |
Morphine formation from codeine in rat brain: a possible mechanism of codeine analgesia.
Topics: Analgesia; Animals; Blood-Brain Barrier; Brain; Codeine; In Vitro Techniques; Male; Methylation; Morphine; Rats; Rats, Inbred Strains | 1990 |
Sex differences and endocrine regulation of morphine oxidation in rat liver.
Topics: Animals; Female; Hypophysectomy; Hypothalamo-Hypophyseal System; Liver; Male; Methylation; Microsomes, Liver; Morphine; Orchiectomy; Oxidation-Reduction; Rats; Rats, Inbred Strains; Sex Characteristics | 1990 |
Characterisation by mass spectrometry and 500-MHz proton nuclear magnetic resonance spectroscopy of penta- and hexasaccharide chains of human foetal gastrointestinal mucins (meconium glycoproteins).
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Chromatography, High Pressure Liquid; Digestive System; Fetus; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Meconium; Methylation; Molecular Sequence Data; Mucins; Oligosaccharides | 1989 |
Structures of O-glycosidically linked oligosaccharides isolated from human meconium glycoproteins.
Topics: Binding Sites; Chromatography, Gel; Chromatography, High Pressure Liquid; Glycoproteins; Glycosides; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Meconium; Methylation; Molecular Structure; Oligosaccharides | 1989 |
Carbohydrate structures of nonspecific cross-reacting antigen-2, a glycoprotein purified from meconium as an antigen cross-reacting with anticarcinoembryonic antigen antibody. Occurrence of complex-type sugar chains with the Gal beta 1----3GlcNAc beta 1--
Topics: Antigen-Antibody Complex; Antigens; Antigens, Neoplasm; Carbohydrate Conformation; Carbohydrate Sequence; Carbohydrates; Carcinoembryonic Antigen; Cell Adhesion Molecules; Cross Reactions; Glycoproteins; Glycoside Hydrolases; Humans; Indicators and Reagents; Infant, Newborn; Meconium; Methylation; Molecular Sequence Data; Oligosaccharides | 1989 |
Novel nonnarcotic analgesics with an improved therapeutic ratio. Structure-activity relationships of 8-(methylthio)- and 8-(acylthio)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocines.
Topics: Acylation; Analgesia; Animals; Brain; Chemical Phenomena; Chemistry; Methylation; Mice; Morphinans; Morphine; Naloxone; Oxygen; Phenazocine; Rabbits; Rats; Receptors, Opioid; Structure-Activity Relationship; Sulfur | 1985 |
Globoseries glycosphingolipids of human meconium.
Topics: Acetylation; Chromatography, Gas; Chromatography, Thin Layer; Globosides; Glycosphingolipids; Humans; Infant, Newborn; Magnetic Resonance Spectroscopy; Mass Spectrometry; Meconium; Methylation; Protons | 1986 |
Supercritical fluid chromatography of glycosphingolipids.
Topics: Chromatography; Gangliosides; Glycolipids; Glycosphingolipids; Humans; Mass Spectrometry; Meconium; Methylation | 1988 |
Precursors of the mammalian synthesis of morphine: (+)-salutaridine and (-)-thebaine from (+)-6-demethylsalutaridine, and (-)-N-13CH3-thebaine from (-)-northebaine.
Topics: Animals; Chemical Phenomena; Chemistry; Circular Dichroism; Methylation; Morphinans; Morphine; Rats; Thebaine | 1986 |
Morphine lethality in rats: effects of inhibitors of brain catecholamine synthesis and methylation.
Topics: Alcohols; Animals; Brain; Catechol O-Methyltransferase Inhibitors; Catecholamines; Cycloheptanes; Dopamine beta-Hydroxylase; Drug Synergism; Lethal Dose 50; Male; Methylation; Methyltyrosines; Morphine; Rats; Thiazoles; Thiourea; Time Factors; Tyrosine 3-Monooxygenase | 1973 |
Effect of nicotine and other drugs on the release of 3H-norepinephrine and 3H-dopamine from rat brain slices.
Topics: Acetylcholine; Animals; Brain; Carbachol; Cerebellum; Cerebral Cortex; Cocaine; Corpus Striatum; Culture Media; Deamination; Dopamine; Edetic Acid; Hexamethonium Compounds; Hypothalamus; In Vitro Techniques; Lidocaine; Methacholine Compounds; Methylation; Morphine; Nicotine; Norepinephrine; Peripheral Nerves; Phenoxybenzamine; Rats; Tritium | 1974 |
Factors influencing the inhibitory effect of carbon monoxide on cytochrome P-450-catalyzed mixed function oxidation reactions.
Topics: Animals; Anisoles; Binding Sites; Carbon Monoxide; Cytochromes; Electron Transport; Electron Transport Complex IV; In Vitro Techniques; Methylation; Metyrapone; Microsomes, Liver; Morphine; Nitroso Compounds; Oxidation-Reduction; Phenobarbital; Rats | 1970 |
Some aspects of the metabolism of morphine-N-oxide.
Topics: Acridines; Analgesics; Animals; Codeine; Cyclic N-Oxides; In Vitro Techniques; Injections, Intraperitoneal; Liver; Male; Methylation; Morphinans; Morphine; Rats; Thiazoles | 1971 |
Chemical constituents of gentianaceae. X. Xanthone-O-glucosides of Swertia purpurascens Wall.
Topics: Amphetamine; Animals; Behavior, Animal; Drug Synergism; Electroshock; Ethers; Glycosides; Hemodynamics; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylation; Mice; Morphine; N,N-Dimethyltryptamine; Plants, Medicinal; Rats; Seizures; Spectrophotometry, Ultraviolet; Xanthines | 1974 |
Stereochemical studies on medicinal agents. 13. Correlation of the solid-state conformations of 1,3,5-trimethyl- and 1,3-dimethyl-4-phenyl-4-propionoxypiperidine enantiomers with their absolute stereoselectivity at analgetic receptors.
Topics: Alphaprodine; Analgesics; Animals; Crystallography; Dose-Response Relationship, Drug; Magnetic Resonance Spectroscopy; Male; Methylation; Mice; Models, Structural; Molecular Conformation; Morphine; Optical Rotation; Reaction Time; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship | 1973 |
A review of some GLD-FID derivitization techniques found useful in forensic toxicology.
Topics: Acetylation; Amphetamine; Bromides; Chromatography, Gas; Forensic Medicine; Formaldehyde; Glycols; Humans; Methadone; Methylation; Morphine; Oxidation-Reduction; Phenytoin; Toxicology | 1974 |
The inhibition of the uptake of monoamines by blood platelets by phenothiazines and other drugs.
Topics: Animals; Antidepressive Agents; Atropine; Biogenic Amines; Blood Platelets; Carbon Radioisotopes; Cell Membrane; Cocaine; Depression, Chemical; Dibenzazepines; Dopamine; Hemolysis; In Vitro Techniques; Metaraminol; Methadone; Methylation; Morphine; Phenothiazines; Serotonin; Structure-Activity Relationship; Surface Tension; Tritium | 1974 |
Effect of 3-methylcholanthrene induction on the carbon tetrachloride-induced changes in rat hepatic microsomal enzyme system.
Topics: Animals; Benzopyrenes; Carbon Tetrachloride Poisoning; Cytochromes; Enzyme Induction; Heme; Male; Methylation; Methylcholanthrene; Microsomes, Liver; Morphine; Rats | 1972 |
Novel analgesics and molecular rearrangements in the morphine-thebaine group. 23. Adducts of thebaine with divinyl sulphone and with methyl vinyl sulphone.
Topics: Alkenes; Analgesics; Chemical Phenomena; Chemistry; Methylation; Morphine; Stereoisomerism; Sulfones; Thebaine; Vinyl Compounds | 1972 |
Species differences in the effect of morphine administration or adrenalectomy on the substrate interactions with cytochrome P-450 and drug oxidations by liver microsomes.
Topics: Adrenal Cortex Hormones; Adrenalectomy; Aminopyrine; Androgens; Aniline Compounds; Animals; Cytochromes; Dealkylation; Depression, Chemical; Female; Hexobarbital; Male; Methylation; Mice; Microsomes, Liver; Morphine; Oxidation-Reduction; Protein Binding; Proteins; Rabbits; Rats; Sex Factors; Species Specificity; Spectrophotometry | 1971 |
The metabolism of chlorpromazine by developing rabbit liver.
Topics: Age Factors; Animals; Animals, Newborn; Biotransformation; Chlorpromazine; Chromatography, Thin Layer; Drug Interactions; Ethionine; Humans; Hydroxylation; In Vitro Techniques; Infant, Newborn; Liver; Methylation; Microsomes, Liver; Morphine; Perfusion; Phenobarbital; Rabbits; Stimulation, Chemical; Sulfides; Sulfoxides; Time Factors | 1971 |
Synthesis of gamma-dimethylaminomethyl-alpha-phenylcycloalkyl propionates as potential analgetics.
Topics: Aluminum; Analgesics; Anhydrides; Animals; Codeine; Cyclohexanes; Lithium; Methylation; Mice; Morphine; Propionates | 1970 |
N-demethylation of N-14C-methyl-codeine in morphine tolerant and nontolerant rats and mice.
Topics: Air; Animals; Carbon Dioxide; Carbon Isotopes; Codeine; Drug Tolerance; Female; Liver; Male; Methylation; Morphine; Rats; Sex Factors | 1971 |
Sex differences in the kinetic constants for the N-demethylation of ethylmorphine by rat liver microsomes.
Topics: Animals; Castration; Female; Kinetics; Liver; Male; Methylation; Microsomes; Morphine; Rats; Sex Factors | 1968 |
18. Cellular adaptation in the development of tolerance to drugs.
Topics: Adaptation, Physiological; Animals; Barbiturates; Dogs; Drug Tolerance; Enzyme Induction; Enzymes; Heart Rate; Humans; Hypnotics and Sedatives; Liver; Methylation; Mice; Microsomes; Morphine; Nalorphine; Narcotic Antagonists; Norepinephrine; Rats; Substance Withdrawal Syndrome; Sympathetic Nervous System; Tachyphylaxis; Tritium; Tyramine | 1968 |
Gangliosides of human meconium - detection of a possible fetal antigen.
Topics: Antigens; Carbohydrate Sequence; Gangliosides; Glycosphingolipids; Humans; Infant, Newborn; Meconium; Methylation; Sialic Acids | 1981 |
Carbohydrate structures of a normal counterpart of the carcinoembryonic antigen produced by colon epithelial cells of normal adults.
Topics: Adult; Antigens, Neoplasm; Carbohydrate Sequence; Carcinoembryonic Antigen; Cell Adhesion Molecules; Chromatography, Affinity; Colon; Cross Reactions; Epithelium; Feces; Glycoside Hydrolases; Humans; Infant, Newborn; Mass Spectrometry; Meconium; Membrane Glycoproteins; Methylation; Molecular Sequence Data; Oligosaccharides; Reference Values | 1995 |
On the assessment of drug metabolism by assays of codeine and its main metabolites.
Topics: Adult; Chromatography, High Pressure Liquid; Codeine; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Female; Glucuronides; Humans; Linear Models; Male; Methylation; Middle Aged; Morphine; Phenotype; Polymorphism, Genetic; Reproducibility of Results; Sensitivity and Specificity | 2000 |
Identification of CYP3A4 and CYP2C8 as the major cytochrome P450 s responsible for morphine N-demethylation in human liver microsomes.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cell Line; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Hydroxylation; Insecta; Methylation; Microsomes, Liver; Molecular Structure; Morphine; Morphine Derivatives | 2003 |
[The demethylation of codeine in vivo].
Topics: Biochemical Phenomena; Blood Glucose; Codeine; Humans; Methylation; Morphine | 1953 |
Metabolic N- and O-demethylation of morphine- and morphinan-type analgesics.
Topics: Analgesics; Liver; Methylation; Morphinans; Morphine; Morphine Derivatives | 1958 |
[Contributions on the physiology of Papaver alkaloids. The demethylation of codeine to morphine in the poppy plant].
Topics: Alkaloids; Codeine; Methylation; Morphine; Papaver | 1960 |
Effect of deuteration of N--CH3 group on potency and enzymatic N-demethylation of morphine.
Topics: Animals; Deuterium; Kinetics; Methylation; Mice; Morphine; Rats | 1961 |
N-METHYLATION OF NORMORPHINE BY RAT TISSUES IN VITRO.
Topics: Brain; Carbon Isotopes; In Vitro Techniques; Liver; Metabolism; Methionine; Methylation; Morphine; Morphine Derivatives; Nucleosides; Rats; Research; Transferases | 1963 |
THE METHYLATION OF NORMORPHINE IN RAT BRAIN IN VIVO.
Topics: Brain; Carbon Isotopes; Metabolism; Methionine; Methylation; Morphine; Morphine Derivatives; Rats; Research | 1963 |
N- AND O-DEMETHYLATION OF SOME NARCOTIC ANALGESICS BY BRAIN SLICES FROM MALE AND FEMALE LONG-EVANS RATS.
Topics: Animals; Brain; Carbon Dioxide; Carbon Isotopes; Codeine; Female; Meperidine; Metabolism; Methylation; Morphine; Narcotics; Rats; Rats, Long-Evans; Research | 1963 |
STUDIES ON THE ENZYMATIC N- AND O-DEMETHYLATION OF NARCOTIC ANALGESICS AND EVIDENCE FOR THE FORMATION OF CODEINE FROM MORPHINE IN RATS AND DOGS.
Topics: Adenosine Triphosphate; Antitussive Agents; Autoradiography; Carbon Isotopes; Chlorides; Chromatography; Codeine; Dogs; Folic Acid; Glutathione; Liver; Metabolism; Methionine; Methylation; Morphine; NADP; Narcotics; Pharmacology; Rats; Research; Urine | 1964 |
A frameshift mutation and alternate splicing in human brain generate a functional form of the pseudogene cytochrome P4502D7 that demethylates codeine to morphine.
Topics: Alternative Splicing; Animals; Base Sequence; Brain; Cell Line, Tumor; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Frameshift Mutation; Gene Expression; Genes; Humans; Isoenzymes; Kidney; Liver; Methylation; Mice; Molecular Sequence Data; Morphine; Pseudogenes; Receptors, Opioid, mu; Recombinant Proteins | 2004 |
An investigation of the N-demethylation of 3-deoxymorphine and the affinity of the alkylation products to mu, delta, and kappa receptors.
Topics: Animals; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Formates; Methylation; Morphine; Morphine Derivatives; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2004 |
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.
Topics: Biocatalysis; Dioxygenases; Methylation; Morphine; Papaver | 2010 |
Biosynthesis: unmasking morphine.
Topics: Cytochrome P-450 CYP1A2; Dioxygenases; Humans; Methylation; Molecular Conformation; Morphine | 2010 |
N-demethylation of N-methyl alkaloids with ferrocene.
Topics: Alkaloids; Catalysis; Ferrous Compounds; Metallocenes; Methylation; Morphine; Thebaine | 2010 |
Automated radiosynthesis of [11C]morphine for clinical investigation.
Topics: Automation, Laboratory; Carbon Radioisotopes; Isotope Labeling; Methylation; Morphine; Radiopharmaceuticals; Solid Phase Extraction | 2011 |
Ultra-low-dose naloxone enhances the antinociceptive effect of morphine in PTX-treated rats: regulation on global histone methylation.
Topics: Analgesics, Opioid; Animals; Histones; Injections, Spinal; Male; Methylation; Morphine; Naloxone; Narcotic Antagonists; Neuralgia; Pertussis Toxin; Rats; Rats, Wistar | 2012 |
Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain.
Topics: Animals; Azacitidine; Cell Line, Tumor; CpG Islands; Decitabine; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Methylation; Mice; Morphine; Neuralgia; Neuroblastoma; Pain Measurement; Pain Threshold; Promoter Regions, Genetic; Receptors, Opioid, mu; Sensory Receptor Cells; Spinal Cord | 2014 |
Cytochrome P450 3A Enzymes Catalyze the O6-Demethylation of Thebaine, a Key Step in Endogenous Mammalian Morphine Biosynthesis.
Topics: Animals; Biocatalysis; Brain; Cytochrome P-450 CYP3A; Humans; Male; Methylation; Microsomes, Liver; Morphine; Rats; Rats, Sprague-Dawley; Thebaine | 2015 |
Differential neurogenic effects of casein-derived opioid peptides on neuronal stem cells: implications for redox-based epigenetic changes.
Topics: Analgesics, Opioid; Animals; Apoptosis; Astrocytes; Caseins; Cattle; Cell Proliferation; Cells, Cultured; DNA Methylation; Endorphins; Epigenesis, Genetic; Glutathione; Humans; Methylation; Morphine; Neural Stem Cells; Neurogenesis; Opioid Peptides; Oxidation-Reduction; Peptide Fragments; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine | 2016 |
Crystal structure of thebaine 6-O-demethylase from the morphine biosynthesis pathway.
Topics: Crystallography, X-Ray; Ketoglutaric Acids; Methylation; Morphine; Oxidoreductases, O-Demethylating; Papaver; Succinic Acid; Thebaine | 2018 |
Methylation Products of 6β- N-Heterocyclic Substituted Naltrexamine Derivatives as Potential Peripheral Opioid Receptor Modulators.
Topics: Analgesics, Opioid; Animals; CHO Cells; Constipation; Cricetulus; Diarrhea; Drug Partial Agonism; Gastrointestinal Agents; Gastrointestinal Transit; Imidazoles; Methylation; Mice; Molecular Docking Simulation; Morphine; Naltrexone; Narcotic Antagonists; Nociception; Phenylalanine; Quaternary Ammonium Compounds; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2018 |
H3K4 dimethylation at FosB promoter in the striatum of chronic stressed rats promotes morphine-induced conditioned place preference.
Topics: Animals; Chronic Disease; Conditioning, Classical; Gene Expression Regulation; Histones; Lysine; Male; Methylation; Models, Biological; Morphine; Neostriatum; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Stress, Psychological; Transcription, Genetic | 2019 |
Enhanced H3K4 Trimethylation in TNF-
Topics: Analgesics, Opioid; Animals; Animals, Newborn; Apoptosis; Brain; Caspase 3; Corpus Striatum; Epigenesis, Genetic; Female; Histones; Maternal Exposure; Methylation; Morphine; Morphine Dependence; Pregnancy; Pregnancy, Animal; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome; Tumor Necrosis Factor-alpha | 2021 |