isomethyleugenol has been researched along with methylnitrosourea in 109 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 73 (66.97) | 18.7374 |
1990's | 32 (29.36) | 18.2507 |
2000's | 2 (1.83) | 29.6817 |
2010's | 2 (1.83) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Kuśmierek, JT; Singer, B | 1 |
Craig, AW; Magin, MN; Margison, GP; O'Connor, PJ | 1 |
Abbott, PJ; Saffhill, R | 3 |
Chang, MJ; Koestner, A; Webb, TE | 1 |
Cox, R; Irving, CC | 1 |
Thielmann, HW | 1 |
Buecheler, J; Cooper, HK; Diessner, H; Kleihues, P; Kolar, GF | 1 |
Carver, JP; Krepinsky, J; Rajalakshmi, S; Rao, PM; Sarma, DS | 1 |
Rajalakshmi, S; Rao, PM; Sarma, DS | 2 |
Farmer, PB; Lawley, PD; Swenson, DH | 1 |
Lawley, PD | 1 |
Frei, JV; Lawley, PD | 1 |
Boffa, LC; Carpaneto, EM; Mariani, MR | 1 |
Fairbairn, L; Klungland, A; Margison, GP; Seeberg, E; Watson, AJ | 1 |
Douglas, KT; Elder, RH; Margison, GP; Rafferty, JA; Tumelty, J | 1 |
Graves, R; Laval, J; Pegg, AE | 1 |
Aresta, A; Farber, E; Kanduc, D; Quagliariello, E | 1 |
Archer, MC; Chaulk, EJ; Lu, SJ | 1 |
Archer, MC; Lu, SJ; Milligan, JR | 1 |
Kleihues, P; Ludeke, BI; Lutz, WK; Meier, I; Ohgaki, H; Schlatter, C | 1 |
Imaeda, T; Kawazoe, Y; Takahashi, K | 1 |
Binková, B; Fojtíková, I; Srám, RJ; Topinka, J | 1 |
Kainzbauer, J; Schoket, B; Stehlik, G | 1 |
Fong, LY; Jensen, DE; Magee, PN | 1 |
Haggerty, HG; Holsapple, MP; Kim, BS | 1 |
Dixit, R; Gold, B | 2 |
Archer, MC; Catz-Biro, L; Hirani-Hojatti, S; Milligan, JR | 1 |
Kawazoe, Y; Nakabeppu, Y; Sakumi, K; Sekiguchi, M; Takahashi, K | 1 |
Fram, RJ; Marinus, MG; Volkert, MR | 1 |
Nakabeppu, Y; Otsuka, M; Sekiguchi, M | 1 |
Abbondandolo, A; Bignami, M; Calcagnile, A; Dogliotti, E; Frosina, G; Terlizzese, M; Zijno, A | 1 |
Hsie, AW; Schröder, CH; Thielmann, HW | 1 |
Berger, ML; Reitman, FA; Shertzer, HG | 1 |
Kawazoe, Y; Takahashi, K | 1 |
Kim, S; Paik, WK; Park, KS; Trézl, L | 1 |
Griffiths, VS; Lewis, DF | 1 |
Becker, FF; Chan, JY; Stout, DL | 1 |
Edler, L; Friemel, S; Thielmann, HW | 1 |
Jensen, DE; Spiegel, A; Stelman, GJ | 1 |
Day, RS; DiPaolo, JA; Doniger, J | 1 |
Topal, MD | 1 |
Korsakov, MV; Ovsiannikov, AI | 1 |
De Brij, RJ; Den Engelse, L; Menkveld, GJ; Tates, AD | 1 |
Castonguay, A; Foiles, PG; Trushin, N | 1 |
Kawasaki, H; Ninomiya, S; Yuki, H | 1 |
Dolan, ME; Pegg, AE | 1 |
Sakai, K; Umeda, T; Yamane, Y | 1 |
Boffa, LC; Bolognesi, C | 1 |
Casalino, E; Kanduc, D; Liuzzi, MG | 1 |
Hiraki, S | 1 |
Rajalakshmi, S; Rao, RM; Sarma, DS | 1 |
Boehm, TL; Drahovsky, D | 2 |
DiMaria, P; Kim, S; Lotlikar, PD; Magee, PN; Paik, WK | 1 |
Likhachev, AJ | 1 |
Grisham, JW; Smith, GJ | 1 |
Bennett, RA; Pegg, AE | 1 |
Boyle, JM; Durrant, LG; Margison, GP | 2 |
Connell, JR; Medcalf, AS | 1 |
Beranek, DT; Heflich, RH; Morris, SM | 1 |
Boiteux, S; Dirheimer, G; Keith, G; Laval, J; Pfohl-Leszkowicz, A | 1 |
Woolley, PV; Yang, PC | 1 |
Ahmed, Z; Ather, A; Riazuddin, S | 1 |
Faustman-Watts, EM; Goodman, JI | 1 |
Beranek, DT; Cox, R; Evans, FE; Irving, CC; Kadlubar, FF; Weis, CC | 1 |
Chen, BP | 1 |
Hemminki, K | 1 |
Dirheimer, G; Fuchs, RP; Keith, G; Pfohl-Leszkowicz, A | 1 |
Asbery, LJ; Chandler, PM; Harris, G; Jones, MG; Lawley, PD | 1 |
Alekandrov, VA; Anisimov, VN; Bespalov, VG; Korsakov, MV; Likhachev, AJ; Napalkov, NP; Ovsyannikov, AI; Popovich, IG; Tomatis, L | 1 |
Baker, MS; Topal, MD | 2 |
Feinberg, A; Zedeck, MS | 1 |
Gowans, BJ; Kastan, MB; Lieberman, MW | 1 |
Harris, G; Lawley, PD; Olsen, I | 1 |
Margison, GP | 1 |
Bogden, JM; Bresnick, E; Eastman, A | 1 |
Berkowitz, EM; Silk, H | 1 |
Becker, Y; Shiloh, Y | 1 |
Owens, JG; Sega, GA; Wolfe, KW | 1 |
Aresta, A; Farber, E; Kanduc, D | 1 |
Kanduc, D | 1 |
O'Connor, PJ; Zaidi, NH | 1 |
Bean, CL; Bradt, CI; Galloway, SM; Greenwood, SK; Hill, RB | 1 |
Branch, P; Hampson, R; Karran, P | 1 |
Aquilina, G; Bignami, M; Ceccotti, S; Fiumicino, S; Hess, P | 1 |
Aquilina, G; Branch, P; Karran, P; Zhukovskaya, N | 1 |
Ito, N; Montesano, R; Ogawa, K; Shibata, MA; Shirai, T; Takahashi, S; Tsuda, H; Wild, CP | 1 |
Hamilton, JW; McCaffrey, J | 1 |
Douskey, MC; Gold, B; Wurdeman, RL | 1 |
Aquilina, G; Bignami, M; Biondo, R; Dogliotti, E | 1 |
Bignami, M; Ceccotti, S; Dogliotti, E; Gannon, J; Karran, P | 1 |
Dosch, J; Fritz, G; Kaina, B; Thielmann, HW | 1 |
Mathison, BH; Said, B; Shank, RC | 1 |
Aquilina, G; Bignami, M; Branch, P; Karran, P | 1 |
Avery, LJ; LeDoux, SP; Patton, NJ; Wilson, GL | 1 |
Atawodi, SE; Mende, P; Preussmann, R; Spiegelhalder, B | 1 |
Gondo, Y; Katsuki, M; Nakao, K; Shioyama, Y | 1 |
Gerson, SL; Liu, L; Qin, X; Zhou, H | 1 |
Druzhyna, N; LeDoux, SP; Smulson, ME; Wilson, GL | 1 |
de Groot, AJ; Jansen, JG; Mohn, GR; Mullenders, LF; van Duijn-Goedhart, AM; van Oostrom, C; van Steeg, H; van Zeeland, AA | 1 |
Lawley, PD; Warren, W | 1 |
Amin, SG; Belinsky, SA; Collins, LB; Crowell, RE; Desai, D; Gilliland, FD; Jauregui, AR; Juri, DE; Leng, S; Lin, Y; Liu, Y; Picchi, MA; Stidley, CA; Swenberg, JA; Tellez, CS; Thomas, CL; Wathelet, MG; Wu, G; Zhang, X | 1 |
Anandi, L; Ashiq, KA; Bodakuntla, S; Chakravarty, V; Lahiri, M | 1 |
4 review(s) available for isomethyleugenol and methylnitrosourea
Article | Year |
---|---|
"Excision" of bases from DNA methylated by carcinogens in vivo and its possible significance in mutagenesis and carcinogenesis.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Carcinogens; Dimethylnitrosamine; DNA; Escherichia coli; Liver; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mutagens; Organ Specificity; Rats; Species Specificity | 1975 |
Mutagenesis by incorporation of alkylated nucleotides.
Topics: Alkylation; Base Composition; Base Sequence; Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; Deoxyribonucleotides; DNA; DNA-Directed DNA Polymerase; Methylation; Methylnitrosourea; Mutation; Nucleic Acid Precursors; Templates, Genetic | 1985 |
DNA repair induced by alkylating carcinogens.
Topics: 1,2-Dimethylhydrazine; Aging; Alkylating Agents; Animals; Carcinogens; Cricetinae; Dimethylhydrazines; Dimethylnitrosamine; DNA Repair; Ethylnitrosourea; Mesocricetus; Methylation; Methylnitrosourea; Rats | 1983 |
Predictive and mechanistic evaluation to toxic responses in mammalian cell culture systems.
Topics: Alkylating Agents; Animals; Cell Division; Cell Line; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Colony-Forming Units Assay; Culture Techniques; Cytological Techniques; Dimethylnitrosamine; Flow Cytometry; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Toxicology | 1984 |
105 other study(ies) available for isomethyleugenol and methylnitrosourea
Article | Year |
---|---|
Sites of alkylation of poly(U) by agents of varying carcinogenicity and stability of products.
Topics: Alkylating Agents; Alkylation; Carcinogens; Chemical Phenomena; Chemistry; Ethyl Methanesulfonate; Ethylnitrosourea; Hydrogen-Ion Concentration; Methylation; Methylnitrosourea; Models, Chemical; Nitrosoguanidines; Phosphoric Acids; Poly U; Ribose; Sulfuric Acids; Uridine | 1976 |
The effect of hormone induced stress upon the extent of alkylation of rat liver nucleic acids by N-methyl-N-nitrosourea.
Topics: Alkylation; Animals; Dimethylnitrosamine; DNA; Drug Synergism; Epinephrine; Hydrocortisone; Liver; Male; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Nitrosourea Compounds; Nucleic Acids; Rats; RNA, Ribosomal; Stress, Physiological | 1975 |
DNA-synthesis with methylated poly(dA-dT) templates: possible role of O4-methylthymine as a pro-mutagenic base.
Topics: DNA; DNA Polymerase I; DNA-Directed DNA Polymerase; Escherichia coli; Genetic Code; Methylation; Methylnitrosourea; Poly dA-dT; Polydeoxyribonucleotides; Sulfates; Templates, Genetic; Thymine | 1977 |
Formation of O2-methylthymine in poly(dA-dT) on methylation with N-methyl-N-nitrosourea and dimethyl sulphate. Evidence that O2-methylthymine does not miscode during DNA synthesis.
Topics: DNA-Directed DNA Polymerase; Escherichia coli; Genetic Code; Methylation; Methylnitrosourea; Nitrosourea Compounds; Poly dA-dT; Polydeoxyribonucleotides; Structure-Activity Relationship; Thymine | 1978 |
DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by O(6)-methylguanine.
Topics: Deoxycytosine Nucleotides; Deoxyguanine Nucleotides; DNA; DNA Polymerase I; Escherichia coli; Genetic Code; Guanine; Methylation; Methylnitrosourea; Polydeoxyribonucleotides; Sulfuric Acid Esters; Templates, Genetic; Thymidine Monophosphate | 1979 |
Distribution of O6-methylguanine in rat DNA following pretreatment in vivo with methylnitrosourea.
Topics: Animals; Brain; DNA; Guanine; Kidney; Liver; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats | 1979 |
O6-methylguanine accumulates in DNA of mammary glands after administration of N-methyl-N-nitrosourea to rats.
Topics: Animals; Brain; DNA; DNA Repair; Female; Guanine; Mammary Glands, Animal; Mammary Neoplasms, Experimental; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats; Urinary Bladder | 1979 |
Rapid determination of methylated purines in DNA treated with N-methyl-N-nitrosourea using high-performance liquid chromatography.
Topics: Adenine; Chromatography, High Pressure Liquid; DNA; Guanine; Methylation; Methylnitrosourea; Nitrosourea Compounds | 1979 |
Mechanism of perinatal tumor induction by neuro-oncogenic alkylnitrosoureas and dialkylaryltriazenes.
Topics: Animals; Brain; DNA; DNA Repair; Female; Fetus; Guanine; Liver; Maternal-Fetal Exchange; Methylation; Methylnitrosourea; Neoplasms, Experimental; Nervous System Diseases; Nitrosourea Compounds; Pregnancy; Rats; Triazenes | 1979 |
Detection by nuclear magnetic resonance of methylation sites on rat liver DNA utilizing magnetically labelled N-methyl-N-nitrosourea and methyl methane sulfonate.
Topics: Animals; DNA; Liver; Magnetic Resonance Spectroscopy; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats | 1979 |
Studies on carcinogen chromatin--DNA interaction: inhibition of N-methyl-N-nitrosourea-induced methylation of chromatin--DNA by spermine and distamycin A.
Topics: Animals; Chromatin; Distamycins; DNA; Liver; Male; Methylation; Methylnitrosourea; Nitrosourea Compounds; Pyrroles; Rats; Spermine | 1978 |
Identification of the methyl phosphotriester of thymidylyl (3',5')thymidine as a product from reaction of DNA with the carcinogen N-methyl-N-nitrosourea.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Deoxyribonucleases; DNA; Methylation; Methylnitrosourea; Nitrosourea Compounds; Thymine Nucleotides | 1976 |
Methylation of DNA in various organs of C57B1 mice by a carcinogenic dose of N-methyl-N-nitrosourea and stabiltty of some methylation products up to 18 hours.
Topics: Adenine; Animals; Bone Marrow; Carbon Radioisotopes; Chromatography, Affinity; Chromatography, Paper; DNA; Female; Guanine; Injections, Intraperitoneal; Intestine, Small; Kidney; Liver; Lung; Methylation; Methylnitrosourea; Mice; Mice, Inbred C57BL; Nitrosourea Compounds; Spleen; Thymus Gland; Time Factors; Tritium | 1975 |
Effects of N-methyl-N-nitrosourea on transcriptionally active and inactive nucleosomes: macromolecular damage and DNA repair.
Topics: Chromatography, Affinity; DNA; DNA Repair; HeLa Cells; Humans; Methylation; Methylnitrosourea; Nucleosomes; Proteins; RNA; Transcription, Genetic | 1992 |
Expression of the E.coli 3-methyladenine DNA glycosylase I gene in mammalian cells reduces the toxic and mutagenic effects of methylating agents.
Topics: Alkylating Agents; Animals; Base Sequence; Cell Line; Cell Survival; Cricetinae; Cricetulus; DNA Glycosylases; DNA Repair; DNA, Single-Stranded; Drug Resistance; Escherichia coli; Genes, Bacterial; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Molecular Sequence Data; Mutagens; N-Glycosyl Hydrolases; Plasmids; Transfection | 1992 |
C-terminally truncated human O6-alkylguanine-DNA alkyltransferase retains activity.
Topics: Animals; Cattle; Cloning, Molecular; Deoxyribonucleases, Type II Site-Specific; DNA; Escherichia coli; Humans; Immunoblotting; Kinetics; Methylation; Methylnitrosourea; Methyltransferases; Molecular Weight; O(6)-Methylguanine-DNA Methyltransferase; Peptide Fragments; Structure-Activity Relationship; Transformation, Bacterial | 1992 |
Sequence specificity of DNA repair by Escherichia coli Fpg protein.
Topics: Base Sequence; DNA Repair; DNA-Formamidopyrimidine Glycosylase; DNA, Bacterial; Endodeoxyribonucleases; Escherichia coli; Escherichia coli Proteins; Guanine; Methylation; Methylnitrosourea; Molecular Sequence Data; N-Glycosyl Hydrolases; Oligonucleotide Probes | 1992 |
Effect of MNU on the methylation pattern of hepatic DNA during compensatory cell proliferation.
Topics: Animals; Cell Division; DNA; Kinetics; Liver; Liver Regeneration; Male; Methylation; Methylnitrosourea; Rats; Rats, Inbred Strains | 1992 |
Formation and repair of O6-methylguanine and methylation of the Ha-ras proto-oncogene by N-methyl-N-nitrosourea are not associated with mammary tumor resistance in the Copenhagen rat.
Topics: Animals; Blotting, Northern; Blotting, Southern; DNA Repair; DNA, Neoplasm; Drug Resistance; Female; Genes, ras; Guanine; Mammary Neoplasms, Experimental; Methylation; Methylnitrosourea; Rats | 1992 |
Preferential methylation of the Ha-ras proto-oncogene by methylnitrosourea in rat mammary glands.
Topics: Animals; Blotting, Northern; Blotting, Southern; DNA; Female; Genes, ras; Guanine; Mammary Glands, Animal; Methylation; Methylnitrosourea; Rats; Rats, Inbred BUF; Restriction Mapping; RNA; Transcription, Genetic | 1991 |
DNA methylation in the digestive tract of F344 rats during chronic exposure to N-methyl-N-nitrosourea.
Topics: Administration, Oral; Animals; Bromodeoxyuridine; Cell Division; Deoxyguanosine; Digestive System; DNA; DNA Damage; Epithelium; Esophagus; Hyperplasia; Immunoblotting; Male; Methylation; Methylnitrosourea; Purines; Rats; Rats, Inbred F344 | 1991 |
Inhibitory effect of cadmium and mercury ions on induction of the adaptive response in Escherichia coli.
Topics: Cadmium; Enzyme Induction; Escherichia coli; Gene Expression Regulation, Bacterial; Hydrocarbons, Iodinated; Mercury; Methylation; Methylnitrosourea; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Ultraviolet Rays | 1991 |
DNA-repair capacity and lipid peroxidation in chronic alcoholics.
Topics: Adult; Alcoholism; Ascorbic Acid; Cells, Cultured; DNA; DNA Repair; Humans; Lipid Peroxidation; Male; Methylation; Methylnitrosourea; Middle Aged; Regression Analysis; Vitamin A; Vitamin B 12; Vitamin E | 1991 |
Repair studies on methylated DNA of CHO cells.
Topics: Animals; Cells, Cultured; DNA; DNA Damage; DNA Repair; Gamma Rays; Methylation; Methylnitrosourea; Purines | 1990 |
DNA methyl-adduct dosimetry and O6-alkylguanine-DNA alkyl transferase activity determinations in rat mammary carcinogenesis by procarbazine and N-methylnitrosourea.
Topics: Animals; DNA; Female; Mammary Neoplasms, Experimental; Methylation; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Procarbazine; Rats; Rats, Inbred Strains | 1990 |
Characterization of the effects of direct alkylators on in vitro immune responses.
Topics: Alkylating Agents; Animals; Antibody Formation; Antigens, Differentiation, T-Lymphocyte; Dimethylnitrosamine; DNA Damage; DNA, Single-Stranded; Female; Immunosuppression Therapy; In Vitro Techniques; Lymphocyte Activation; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; T-Lymphocytes | 1990 |
Mechanism of inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA binding by ellagic acid.
Topics: Animals; Benzopyrans; DNA; Ellagic Acid; Fruit; Methylation; Methylnitrosourea; Mutation; Rats; RNA; Vegetables | 1987 |
Methylation of DNA by three N-nitroso compounds: evidence for sequence specific methylation by a common intermediate.
Topics: Base Sequence; Dimethylnitrosamine; DNA; DNA Restriction Enzymes; Guanine; Methylation; Methylnitrosourea; Nitrosamines; Nitroso Compounds; Plasmids; Polydeoxyribonucleotides | 1989 |
Activation of Ada protein as a transcriptional regulator by direct alkylation with methylating agents.
Topics: Alkylation; Animals; Bacterial Proteins; Cattle; DNA; Escherichia coli; Hydrocarbons, Iodinated; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Promoter Regions, Genetic; Transcription Factors; Transcription, Genetic | 1988 |
Gene expression in E. coli after treatment with streptozotocin.
Topics: Alkylating Agents; Anaerobiosis; Bacterial Proteins; Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Recombinant Fusion Proteins; Streptozocin; Transcriptional Activation | 1988 |
Ability of various alkylating agents to induce adaptive and SOS responses: a study with lacZ fusion.
Topics: Alkylating Agents; Bacterial Proteins; beta-Galactosidase; DNA Glycosylases; DNA Ligases; DNA Repair; Dose-Response Relationship, Drug; Enzyme Induction; Escherichia coli; Ethylnitrosourea; Genes, Bacterial; Genes, Synthetic; Guanine; Lac Operon; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; N-Glycosyl Hydrolases; Polynucleotide Ligases | 1985 |
Cytotoxicity, mutations and SCEs induced by methylating agents are reduced in CHO cells expressing an active mammalian O6-methylguanine-DNA methyltransferase gene.
Topics: 4-Nitroquinoline-1-oxide; Alkylation; Animals; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; DNA; Dose-Response Relationship, Drug; Guanine; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Mutation; Ouabain; Sister Chromatid Exchange | 1987 |
Formation and removal of DNA adducts after treatment of Chinese hamster ovary cells with N-methyl- and N-ethyl-N-nitrosourea.
Topics: Alkylation; Animals; Cell Line; Cricetinae; DNA; DNA Damage; DNA Mutational Analysis; DNA Repair; Ethylnitrosourea; Methylation; Methylnitrosourea; Time Factors | 1988 |
Toxicity of methylating agents in isolated hepatocytes.
Topics: Animals; Cell Survival; Dimethylnitrosamine; Lipid Peroxides; Liver; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Promethazine; Rats; Rats, Inbred Strains | 1988 |
Inhibition of N-methyl-N-nitrosourea-induced mutagenicity and DNA methylation by ellagic acid.
Topics: Benzopyrans; DNA; Dose-Response Relationship, Drug; Ellagic Acid; Guanine; Methylation; Methylnitrosourea; Mutation; Spermidine | 1986 |
Methyl iodide, a potent inducer of the adaptive response without appreciable mutagenicity in E. coli.
Topics: DNA Repair; Drug Synergism; Escherichia coli; Genes, Bacterial; Hydrocarbons, Iodinated; Methylation; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase | 1987 |
Studies on in vitro S-methylation of naturally occurring thiol compounds with N-methyl-N-nitrosourea and methyl methanesulfonate.
Topics: Amino Acids; Glutathione; Kinetics; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Oxidation-Reduction | 1987 |
Molecular electrostatic potential energies and methylation of DNA bases: a molecular orbital-generated quantitative structure-activity relationship.
Topics: Alkylating Agents; Chemical Phenomena; Chemistry, Physical; DNA; Methylation; Methylnitrosourea; Nucleic Acid Conformation; Structure-Activity Relationship | 1987 |
Protective role of thiols in carcinogen-induced DNA damage in rat liver.
Topics: Acetylcysteine; Animals; Carcinogens; Diethylnitrosamine; DNA; DNA Damage; Female; Glutathione; Liver; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Tiopronin | 1986 |
Xeroderma pigmentosum patients from Germany: repair capacity of 45 XP fibroblast strains of the Mannheim XP Collection as measured by colony-forming ability and unscheduled DNA synthesis following treatment with methyl methanesulfonate and N-methyl-N-nitr
Topics: Alkylation; Carcinogens; Cell Cycle; Colony-Forming Units Assay; DNA; DNA Repair; Fibroblasts; Humans; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Xeroderma Pigmentosum | 1986 |
Species differences in blood-mediated nitrosocimetidine denitrosation.
Topics: Animals; Cimetidine; Cricetinae; DNA; DNA Damage; Guinea Pigs; Hemoglobins; Hydrogen-Ion Concentration; Methylation; Methylnitrosourea; Mice; Rats; Species Specificity; Sulfhydryl Compounds | 1987 |
Quantitative assessment of the role of O6-methylguanine in the initiation of carcinogenesis by methylating agents.
Topics: Animals; Cell Transformation, Neoplastic; Cricetinae; DNA; Dose-Response Relationship, Drug; Female; Guanine; Mesocricetus; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Pregnancy | 1985 |
[DNA alkylation and repair in female rats subjected to methylnitrosourea exposure at different ages].
Topics: Aging; Alkylation; Animals; Carbon Radioisotopes; DNA; DNA Repair; Female; Methylation; Methylnitrosourea; Purines; Rats; Time Factors; Tissue Distribution | 1986 |
Formation and stability of alkylated pyrimidines and purines (including imidazole ring-opened 7-alkylguanine) and alkylphosphotriesters in liver DNA of adult rats treated with ethylnitrosourea or dimethylnitrosamine.
Topics: Alkylation; Animals; Chromatography, High Pressure Liquid; Dimethylnitrosamine; DNA; Ethylnitrosourea; Kinetics; Liver; Male; Methylation; Methylnitrosourea; Phosphates; Purines; Pyrimidines; Rats | 1986 |
Measurement of O6-methyldeoxyguanosine in DNA methylated by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone using a biotin-avidin enzyme-linked immunosorbent assay.
Topics: Animals; Avidin; Biotin; Cattle; Cells, Cultured; Deoxyguanosine; DNA; Enzyme-Linked Immunosorbent Assay; Methylation; Methylnitrosourea; Nasal Mucosa; Nicotiana; Nitrosamines; Plants, Toxic; Rats; Rats, Inbred F344; Thymus Gland; Tissue Distribution | 1985 |
High-performance liquid chromatographic determination of 3-methylcytosine in deoxyribonucleic acid treated with carcinogenic methylating agents in vitro and in vivo.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Cytosine; Dimethylnitrosamine; DNA; Liver; Male; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Thymus Gland | 1985 |
Extent of formation of O4-methylthymidine in calf thymus DNA methylated by N-methyl-N-nitrosourea and lack of repair of this product by rat liver O6-alkylguanine-DNA-alkyltransferase.
Topics: Animals; DNA; DNA Repair; Liver; Methylation; Methylnitrosourea; Methyltransferases; O(6)-Methylguanine-DNA Methyltransferase; Rats; Thymidine | 1985 |
In vitro DNA methylation by methylnitrosourea in isolated copper- or silver-preloaded rat liver nuclei.
Topics: Animals; Cell Nucleus; Copper; DNA; Guanine; In Vitro Techniques; Liver; Male; Methylation; Methylnitrosourea; Rats; Rats, Inbred Strains; Silver | 1985 |
Nuclear proteins damage by alkylating agents with different degrees of carcinogenicity.
Topics: Alkylating Agents; Alkylation; Animals; Carcinogens; Cells, Cultured; Cricetinae; Cricetulus; DNA; Liver; Male; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Microsomes, Liver; Nucleoproteins; Rats; Rats, Inbred Strains | 1985 |
tRNA-methylnitrosourea reaction: formation of 1,7-dimethylguanosine.
Topics: Animals; Cattle; Guanosine; Hydrogen-Ion Concentration; Liver; Methylation; Methylnitrosourea; RNA, Transfer; Time Factors | 1985 |
Induction of malignant lymphomas by N,N'-dimethylnitrosourea in adult mice.
Topics: Animals; Carcinogens; Female; Lymphatic Metastasis; Lymphoma; Male; Methylation; Methylnitrosourea; Mice; Microscopy, Electron; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Nitroso Compounds; Nitrosourea Compounds; Thymus Neoplasms; Urea | 1971 |
Carcinogen-DNA interaction: differential effects of distamycin-a and spermine on the formation of 7-methylguanine in DNA by N-methyl-N-nitrosourea, methylmethanesulfonate, and dimethylsulfate.
Topics: Animals; Carcinogens; Distamycins; DNA; Drug Interactions; Guanine; Liver; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Pyrroles; Rats; Spermine; Sulfuric Acid Esters | 1980 |
Alteration of enzymatic DNA methylation by chemical carcinogens.
Topics: Animals; Base Sequence; Burkitt Lymphoma; Carcinogens; Cell Line; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Restriction Enzymes; Humans; Kinetics; Mast-Cell Sarcoma; Methylation; Methylnitrosourea; Methyltransferases; Mice | 1983 |
Alkylation of protein by methyl methanesulfonate and 1-methyl-1-nitrosourea in vitro.
Topics: Alkylating Agents; Amino Acids; Chymotrypsin; Cytochrome c Group; Histone-Lysine N-Methyltransferase; Hydrogen-Ion Concentration; In Vitro Techniques; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Nitrosourea Compounds; Peptides; Protein Methyltransferases; Proteins | 1984 |
Alkylation of DNA in rat tissues following administration of streptozotocin.
Topics: Animals; Carcinogens; Chromatography, High Pressure Liquid; DNA; Female; Injections, Intravenous; Intestinal Mucosa; Methylation; Methylnitrosourea; Niacinamide; Pancreas; Purines; Rats; Streptozocin | 1981 |
Effects of 5-methylnicotinamide on mouse L1210 cells exposed to N-methyl-N-nitrosourea: mutation induction, formation and removal of methylation products in DNA, and unscheduled DNA synthesis.
Topics: Animals; Cells, Cultured; DNA Repair; DNA, Neoplasm; Leukemia L1210; Methylation; Methylnitrosourea; Mice; Mutagens; Niacinamide; Nitrosourea Compounds; Purines | 1981 |
The induction of SCE with relation to specific base methylation of DNA in Chinese hamster cells by N-methyl-N-nitrosourea and dimethylsulfate.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA; Fibroblasts; Lung; Male; Methylation; Methylnitrosourea; Nitrosourea Compounds; Purines; Sister Chromatid Exchange; Sulfuric Acid Esters; Sulfuric Acids | 1984 |
The relationship between sister-chromatid exchange induction and the formation of specific methylated DNA adducts in Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Crossing Over, Genetic; DNA; Female; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Ovary; Sister Chromatid Exchange | 1983 |
Enzymatic methylation of chemically alkylated DNA and poly(dG-dC) X poly(dG-dC) in B and Z forms.
Topics: Alkylation; Animals; Cattle; Chickens; DNA; DNA (Cytosine-5-)-Methyltransferases; Methylation; Methylnitrosourea; Nucleic Acid Conformation; Polydeoxyribonucleotides; Sulfuric Acid Esters | 1983 |
Thermal melting of chromatin from the pancreas and liver of guinea pigs treated with 1-methyl-1-nitrosourea.
Topics: Alkylation; Animals; Chromatin; DNA; Electrophoresis, Agar Gel; Female; Guinea Pigs; Liver; Methylation; Methylnitrosourea; Nitrosourea Compounds; Nucleic Acid Denaturation; Pancreas; Protein Denaturation | 1984 |
Adaptive response of Micrococcus luteus to alkylating chemicals.
Topics: Alkylating Agents; DNA Repair; DNA, Bacterial; Drug Resistance; Kinetics; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Micrococcus; Structure-Activity Relationship | 1984 |
DNA-purine methylation in hepatic chromatin following exposure to dimethylnitrosamine or methylnitrosourea.
Topics: Animals; Chromatin; Dimethylnitrosamine; DNA; Liver; Male; Methylation; Methylnitrosourea; Mutation; Nitrosourea Compounds; Purines; Rats; Rats, Inbred Strains | 1984 |
Characterization of the purine ring-opened 7-methylguanine and its persistence in rat bladder epithelial DNA after treatment with the carcinogen N-methylnitrosourea.
Topics: Animals; Chromatography, High Pressure Liquid; DNA; Epithelium; Female; Magnetic Resonance Spectroscopy; Methylation; Methylnitrosourea; Nitrosourea Compounds; Pyrimidines; Rats; Rats, Inbred Strains; Tritium; Urinary Bladder | 1984 |
Inhibition of DNA-directed beta-galactosidase synthesis in a cell-free system by dimethyl sulfate and N-methyl-N-nitrosourea.
Topics: Alkylating Agents; beta-Galactosidase; Cell-Free System; DNA; Galactosidases; In Vitro Techniques; Kinetics; Methylation; Methylnitrosourea; Nitrosourea Compounds; Sulfuric Acid Esters; Sulfuric Acids; Templates, Genetic | 1980 |
Reactions of methylnitrosourea, epichlorohydrin, styrene oxide and acetoxyacetylaminofluorene with polyamino acids.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Chemical Phenomena; Chemistry; Chlorohydrins; DNA; Epichlorohydrin; Epoxy Compounds; Ethers, Cyclic; Hydrogen-Ion Concentration; Kinetics; Methylation; Methylnitrosourea; Nitrosourea Compounds; Peptides; Time Factors | 1983 |
Enzymatic methylation of chicken erythrocyte DNA modified by two carcinogens, 2-(N-acetoxyacetylamino) fluorene and methylnitrosourea.
Topics: 2-Acetylaminofluorene; Acetoxyacetylaminofluorene; Alkylation; Animals; Brain; Chickens; DNA; DNA (Cytosine-5-)-Methyltransferases; Erythrocytes; Kinetics; Methylation; Methylnitrosourea; Methyltransferases; Nitrosourea Compounds; Rats | 1983 |
Autoimmune haemolytic disease in mice after exposure to a methylating carcinogen.
Topics: Anemia, Hemolytic, Autoimmune; Animals; DNA; Dose-Response Relationship, Drug; Guanine; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nitrosourea Compounds; Species Specificity; Spleen; Thymoma; Thymus Neoplasms | 1983 |
Persistence of methylated purines in the DNA of various rat fetal and maternal tissues and carcinogenesis in the offspring following a single transplacental dose of N-methyl-N-nitrosourea.
Topics: Adenine; Animals; Brain; DNA; Female; Fetus; Guanine; Kidney; Liver; Methylation; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds; Placenta; Pregnancy; Purines; Rats; Time Factors | 1983 |
Reaction of dATP with N-methyl-N-nitrosourea in vitro.
Topics: Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Deoxyadenine Nucleotides; Hydrogen-Ion Concentration; In Vitro Techniques; Methylation; Methylnitrosourea; Nitrosourea Compounds | 1983 |
DNA precursor pool: a significant target for N-methyl-N-nitrosourea in C3H/10T1/2 clone 8 cells.
Topics: Adenine; Animals; Carcinogens; Cell Line; Clone Cells; Deoxyribonucleotides; DNA; Dose-Response Relationship, Drug; Methylation; Methylnitrosourea; Mice; Mice, Inbred C3H; Nitrosourea Compounds; Phosphates; Time Factors | 1982 |
Production of a highly reactive alkylating agent from the organospecific carcinogen methylazoxymethanol by alcohol dehydrogenase.
Topics: Alcohol Oxidoreductases; Alkylating Agents; Azo Compounds; Hydrogen-Ion Concentration; Methylation; Methylazoxymethanol Acetate; Methylnitrosourea | 1980 |
Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA.
Topics: Acetoxyacetylaminofluorene; Cell Division; Cell Line; Deoxycytidine; DNA; DNA Repair; DNA Replication; Fibroblasts; Humans; Methylation; Methylnitrosourea; Ultraviolet Rays | 1982 |
Hypomethylation of DNA in Raji cells after treatment with N-methyl-N-nitrosourea.
Topics: Burkitt Lymphoma; Cell Division; Cell Line; DNA; Humans; Methylation; Methylnitrosourea; Neoplasms, Experimental; Nitrosourea Compounds | 1981 |
Pretreatment of Chinese hamster v79 cells with MNU increases survival without affecting DNA repair or mutagenicity.
Topics: Animals; Cell Survival; Cells, Cultured; Cricetinae; DNA; DNA Repair; Methylation; Methylnitrosourea; Mutagens; Nitrosourea Compounds; Purines; Time Factors | 1981 |
Mode of action of methylating carcinogens: comparative studies of murine and human cells.
Topics: Animals; Carcinogens; Cells, Cultured; DNA; Guanine; Humans; Lymphocytes; Methylation; Methylnitrosourea; Mice; Mice, Inbred Strains; Species Specificity | 1981 |
Effect of pretreatment of rats with N-methyl-N-nitrosourea on the repair of O(6)-methylguanine in liver DNA.
Topics: 1,2-Dimethylhydrazine; Animals; Dimethylhydrazines; DNA Repair; Guanine; Male; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats | 1981 |
A system in mouse liver for the repair of O6-methylguanine lesions in methylated DNA.
Topics: Amino Acids; Animals; DNA; DNA Repair; Guanine; Kinetics; Liver; Male; Methylation; Methylnitrosourea; Mice; Mice, Inbred C57BL; Proteins | 1981 |
Methylation of chromosomal DNA by two alkylating agents differing in carcinogenic potential.
Topics: Alkylating Agents; Animals; Carcinogens; Deoxyribonucleases; DNA; In Vitro Techniques; Methylation; Methylnitrosourea; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Sulfuric Acid Esters; Sulfuric Acids; Transcription, Genetic | 1981 |
Kinetics of O6-methylguanine repair in human normal and ataxia telangiectasia cell lines and correlation of repair capacity with cellular sensitivity to methylating agents.
Topics: Adolescent; Adult; Alkylating Agents; Ataxia Telangiectasia; Cell Division; Cells, Cultured; Child; DNA; DNA Repair; Female; Guanine; Humans; Infant, Newborn; Kinetics; Male; Methyl Methanesulfonate; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1981 |
A comparison of the molecular action of an SN1-type methylating agent, methyl nitrosourea and an SN2-type methylating agent, methyl methanesulfonate, in the germ cells of male mice.
Topics: Alkylating Agents; Animals; DNA; Male; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mice; Nitrosourea Compounds; Sperm Head; Spermatozoa; Time Factors | 1981 |
Carcinogen-DNA interaction: complexing of distamycin-A with DNA is necessary for its inhibitory effect on the N-methyl-N-nitrosourea induced methylation of DNA.
Topics: Animals; Distamycins; DNA; Methylation; Methylnitrosourea; Nitrosourea Compounds; Pyrroles; Rats | 1981 |
Hypermethylation of replicating hepatic DNA following N-methyl-N-nitrosourea administration.
Topics: Animals; Deoxyribonuclease HpaII; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Damage; DNA Replication; Hepatectomy; Liver; Liver Neoplasms, Experimental; Male; Methylation; Methylnitrosourea; Mitogens; Rats; Rats, Wistar; Sensitivity and Specificity; Tritium | 1994 |
N-methyl-N-nitrosourea evidences cell cycle associated transient sequences in hepatic replicating DNA.
Topics: Animals; Cell Cycle; DNA; DNA Replication; Liver; Liver Regeneration; Male; Methylation; Methylnitrosourea; Rats; Rats, Wistar | 1995 |
Identification in rat stomach mucosae of a cell population characterized by a deficiency for the repair of O6-methyldeoxyguanosine from DNA.
Topics: Animals; Carcinogens; Deoxyguanosine; DNA; DNA Repair; Duodenum; Gastric Mucosa; Immunohistochemistry; Male; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Rats; Rats, Wistar | 1995 |
A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells.
Topics: Alkylating Agents; B-Lymphocytes; Cell Line; Chromosome Aberrations; Dimethylnitrosamine; DNA Repair; Dose-Response Relationship, Drug; Drug Resistance; Erythroid Precursor Cells; Guanine; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea | 1995 |
DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.
Topics: Adenocarcinoma; Colorectal Neoplasms; DNA Damage; DNA Repair; DNA, Neoplasm; DNA, Satellite; Humans; Hypoxanthine Phosphoribosyltransferase; Methylation; Methylnitrosourea; Methyltransferases; Mutation; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Sensitivity and Specificity; Tumor Cells, Cultured | 1995 |
A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.
Topics: Cell Survival; DNA Damage; DNA Repair; DNA, Neoplasm; DNA, Satellite; Dose-Response Relationship, Drug; Drug Resistance; Genetic Complementation Test; Guanine; HeLa Cells; Humans; Methylation; Methylnitrosourea; Methyltransferases; Mutagenesis; O(6)-Methylguanine-DNA Methyltransferase; Phenotype; Thioguanine | 1995 |
DNA replication arrest and tolerance to DNA methylation damage.
Topics: DNA Damage; DNA Replication; DNA, Neoplasm; Ethylnitrosourea; HeLa Cells; Humans; Methylation; Methylnitrosourea; Phenotype; Signal Transduction | 1994 |
DNA methylation adduct formation and H-ras gene mutations in progression of N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder tumors caused by a single exposure to N-methyl-N-nitrosourea.
Topics: Administration, Oral; Animals; Base Sequence; Butylhydroxybutylnitrosamine; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Deoxyguanosine; Disease Progression; DNA Adducts; DNA Damage; DNA Mutational Analysis; DNA, Neoplasm; Genes, ras; Injections, Intraperitoneal; Male; Methylation; Methylnitrosourea; Molecular Sequence Data; Neoplasm Invasiveness; Polymerase Chain Reaction; Rats; Rats, Inbred F344; Urinary Bladder Neoplasms | 1994 |
Comparison of effects of direct-acting DNA methylating and ethylating agents on inducible gene expression in vivo.
Topics: Alkylating Agents; Animals; Carcinogens; Chick Embryo; DNA; DNA Damage; Enzyme Induction; Ethyl Methanesulfonate; Ethylnitrosourea; Genes; Methyl Methanesulfonate; Methylation; Methylnitrosourea; Mutagenesis, Site-Directed; Phosphoenolpyruvate Carboxykinase (GTP) | 1994 |
DNA methylation by N-methyl-N-nitrosourea: methylation pattern changes in single- and double-stranded DNA, and in DNA with mismatched or bulged guanines.
Topics: Autoradiography; Base Sequence; Circular Dichroism; DNA; DNA, Single-Stranded; Guanine; Hot Temperature; Methylation; Methylnitrosourea; Molecular Sequence Data; Nucleic Acid Heteroduplexes | 1993 |
Genetic consequences of tolerance to methylation DNA damage in mammalian cells.
Topics: Adenine; Adenine Phosphoribosyltransferase; Animals; Aza Compounds; Base Sequence; Cell Survival; CHO Cells; Cricetinae; DNA; DNA Damage; Drug Resistance; Guanine; Methylation; Methylnitrosourea; Molecular Sequence Data; Mutation; Ouabain; Thioguanine | 1993 |
O6-methylguanine in DNA inhibits replication in vitro by human cell extracts.
Topics: Antigens, Polyomavirus Transforming; Deoxyribonucleases, Type II Site-Specific; DNA Repair; DNA Replication; DNA, Viral; Guanine; HeLa Cells; Humans; Kinetics; Methylation; Methylnitrosourea; Plasmids; Simian virus 40 | 1993 |
Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.
Topics: Amino Acid Sequence; Animals; Blood; CHO Cells; Cloning, Molecular; Cricetinae; DNA; DNA Repair; Drug Resistance; HeLa Cells; Humans; Methylation; Methylnitronitrosoguanidine; Methylnitrosourea; Molecular Sequence Data; Mutagens; Neoplasms; Nucleic Acid Hybridization; Phenotype; Sequence Homology, Amino Acid; Transfection | 1993 |
Effect of 5-methylcytosine as a neighboring base on methylation of DNA guanine by N-methyl-N-nitrosourea.
Topics: 5-Methylcytosine; Autoradiography; Base Sequence; Cytosine; DNA; DNA Damage; Guanine; Humans; Methylation; Methylnitrosourea; Molecular Sequence Data | 1993 |
Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.
Topics: Animals; Base Sequence; CHO Cells; Cricetinae; DNA Damage; DNA Repair; Drug Resistance; Guanosine; Humans; Methylation; Methylnitrosourea; Molecular Sequence Data; Mutation; Nucleic Acid Heteroduplexes; Oligodeoxyribonucleotides; Phenotype; Thymidine; Tumor Cells, Cultured | 1993 |
Repair of N-methylpurines in the mitochondrial DNA of xeroderma pigmentosum complementation group D cells.
Topics: Blotting, Southern; Cell Line; DNA Damage; DNA Repair; DNA, Mitochondrial; Genetic Complementation Test; Guanine; Humans; Methylation; Methylnitrosourea; Xeroderma Pigmentosum | 1993 |
Detection of methylating activity due to nitrosamide in some nitrosated Nigerian foodstuffs.
Topics: Carcinogens; Chromatography, Gas; Condiments; Humans; Methylation; Methylnitrosourea; Nigeria; Nitrosation; Nitroso Compounds; Vegetables | 1996 |
A novel positive detection system of in vivo mutations in rpsL (strA) transgenic mice.
Topics: Animals; Blotting, Southern; DNA; DNA Modification Methylases; Electroporation; Escherichia coli; Escherichia coli Proteins; Female; Gene Dosage; Genetic Markers; Genetic Vectors; Liver; Male; Methylation; Methylnitrosourea; Mice; Mice, Transgenic; Mutagens; Mutation; Phosphotransferases (Alcohol Group Acceptor); Ribosomal Protein S9; Transformation, Genetic | 1996 |
Transgenic expression of human MGMT blocks the hypersensitivity of PMS2-deficient mice to low dose MNU thymic lymphomagenesis.
Topics: Adenosine Triphosphatases; Animals; Carcinogens; DNA; DNA Damage; DNA Repair; DNA Repair Enzymes; DNA-Binding Proteins; Drug Resistance; Genes, ras; Genetic Complementation Test; Humans; Lymphoma; Methylation; Methylnitrosourea; Mice; Mice, Knockout; Mice, Transgenic; Mismatch Repair Endonuclease PMS2; O(6)-Methylguanine-DNA Methyltransferase; Proteins; Recombinant Fusion Proteins; Thymus Neoplasms | 1999 |
Poly(ADP-ribose) polymerase facilitates the repair of N-methylpurines in mitochondrial DNA.
Topics: Alkylation; Animals; Apoptosis; Dexamethasone; DNA Repair; DNA, Mitochondrial; Genetic Vectors; Glucocorticoids; Insulinoma; Methylation; Methylnitrosourea; Mice; Mice, Knockout; Poly(ADP-ribose) Polymerases; Polymerase Chain Reaction; Purines; Rats; RNA, Antisense; Transfection; Tumor Cells, Cultured | 2000 |
Reduced methylation-induced mutagenesis in rat splenocytes in vivo by sub-chronic low dose exposure to N-metyl-N-nitrosourea.
Topics: Alkylating Agents; Animals; Body Weight; Dose-Response Relationship, Drug; Male; Methylation; Methylnitrosourea; Mutagenesis; Rats; Rats, Wistar; Spleen; Time Factors | 2008 |
The removal of alkylation products from the DNA of Escherichia coli cells treated with the carcinogens N-ethyl-N-nitrosourea and N-methyl-N-nitrosourea: influence of growth conditions and DNA repair defects.
Topics: Adenine; Alkylating Agents; Alkylation; Carcinogens; DNA Repair; DNA, Bacterial; Escherichia coli; Ethylnitrosourea; Guanine; Methylation; Methylnitrosourea | 1980 |
Implication of a Chromosome 15q15.2 Locus in Regulating UBR1 and Predisposing Smokers to MGMT Methylation in Lung.
Topics: Base Sequence; Chromosomes, Human, Pair 15; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Epithelial Cells; Female; Gene Expression Regulation; Genetic Predisposition to Disease; Genome-Wide Association Study; Guanine; Humans; Longitudinal Studies; Lung Neoplasms; Male; Methylation; Methylnitrosourea; Molecular Sequence Data; Polymorphism, Single Nucleotide; Smoking; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2015 |
DNA-dependent protein kinase plays a central role in transformation of breast epithelial cells following alkylation damage.
Topics: Alkylating Agents; Benzaldehydes; Cell Line, Tumor; Cell Transformation, Neoplastic; Comet Assay; DNA-Activated Protein Kinase; Epithelial Cells; Epithelial-Mesenchymal Transition; Female; Golgi Apparatus; Humans; Mammary Glands, Human; Methylation; Methylnitrosourea; Protein Kinase Inhibitors | 2017 |