isomethyleugenol has been researched along with methotrexate in 45 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 15 (33.33) | 18.7374 |
1990's | 13 (28.89) | 18.2507 |
2000's | 7 (15.56) | 29.6817 |
2010's | 7 (15.56) | 24.3611 |
2020's | 3 (6.67) | 2.80 |
Authors | Studies |
---|---|
Montgomery, JA; Piper, JR | 1 |
Freeman-Narrod, M | 1 |
Cronstein, BN | 2 |
Cheng, YC; Degraw, JI; Dutschman, GE; Nair, MG; Sirotnak, FM; Ueda, T | 1 |
Conrad, AH; Ruddle, FH | 1 |
Potter, VR; Sneider, TW | 1 |
Hutchison, DJ; Philips, FS; Sirotnak, FM; Sodergren, JE | 1 |
Brin, H; Grossowicz, N; Selhub, J | 1 |
Argoudelis, AD; Johnson, LE; Pyke, TR | 1 |
Crusberg, TC; Kisliuk, RL; Leary, R | 1 |
Goldman, ID | 1 |
Himmelfarb, P; Roberts, D; Thayer, PS | 1 |
Dunlap, RB; Harding, NG; Huennekens, FM | 1 |
Barak, AJ; Beckenhauer, HC; Tuma, DJ | 1 |
Barak, AJ; Tuma, DJ | 1 |
Barak, AJ; Kemmy, RJ; Tuma, DJ | 1 |
Dolnick, BJ; Hsueh, CT | 1 |
Bottiglieri, T; Hyland, K; Reynolds, EH | 1 |
Jahan, N; Mitsuya, H; O'Brien, MC; Ueno, T; Zajac-Kaye, M | 1 |
Hotta, T; Ichikawa, A; Ito, T; Kagami, Y; Ohashi, H; Saito, H | 1 |
Beland, JL; Hahn, PJ; Longo, JA | 1 |
Pérez de Miguelsanz, J; Ragel, C; Varela-Moreiras, G | 1 |
Blom, HJ; Bökkerink, JP; De Abreu, RA; Keuzenkamp-Jansen, CW; Trijbels, JM | 1 |
Cronstein, BN; Merrill, JT | 1 |
Fiskerstrand, T; Refsum, H; Ueland, PM | 1 |
Aarbakke, J; Giverhaug, T; Loennechen, T | 1 |
Seitz, M | 1 |
Bergo, MO; Casey, PJ; James, SJ; Kamen, BA; Melnyk, S; Winter-Vann, AM; Young, SG | 1 |
Philips, MR | 1 |
Ambrosetti, A; Arrigoni, G; Capello, D; Dell'Oro, S; Ferrarese, F; Ferreri, AJ; Foppoli, M; Gaidano, G; Iuzzolino, P; Orvieto, E; Pasini, F; Ponzoni, M; Reni, M; Rossi, D | 1 |
Choi, HI; Choi, JE; Choi, JM; Kim, DH; Sul, CA; Yoon, SY | 1 |
Becker, A; Bode, U; Jaehde, U; Schüsseler, P; Vezmar, S | 1 |
Albrieux, C; Block, MA; De Brouwer, V; Douce, R; Gambonnet, B; Lambert, WE; Loizeau, K; Ravanel, S; Rebeille, F; Van Der Straeten, D; Van Wilder, V | 1 |
Cohen, IJ | 1 |
Neradil, J; Pavlasova, G; Veselska, R | 1 |
Cabezas-Herrera, J; Fernández-Pérez, MP; Montenegro, MF; Piñero-Madrona, A; Rodríguez-López, JN; Sáez-Ayala, M; Sánchez-del-Campo, L | 1 |
Andrade, AF; Borges, KS; Castro-Gamero, AM; de Paula Queiroz, RG; Moreno, DA; Oliveira, JC; Scrideli, CA; Silveira, VS; Suazo, VK; Tone, LG | 1 |
Bostrom, B; Gandrud, L; Melachuri, S | 1 |
Kawamura, N; Matsuyama, R; Omasa, T; Yamano, N | 1 |
Brown, PM; Isaacs, JD; Pratt, AG | 1 |
Albrecht, LV; Bui, MH; De Robertis, EM | 1 |
Li, M; Sun, LL; Wang, SM; Wu, WS; Yan, D | 1 |
Assirelli, E; Ciaffi, J; Govoni, M; Gremese, E; Meliconi, R; Pulsatelli, L; Ravaei, A; Rubini, M; Salvarani, C; Tolusso, B | 1 |
Fang, Q; Hao, Q; Huang, X; Mi, Y; Wang, J; Wang, Y; Wei, H; Zhang, P | 1 |
8 review(s) available for isomethyleugenol and methotrexate
Article | Year |
---|---|
Molecular mechanism of methotrexate action in inflammation.
Topics: Adjuvants, Immunologic; Cells; Humans; Inflammation; Methotrexate; Methylation | 1992 |
Betaine, metabolic by-product or vital methylating agent?
Topics: Alcohol Oxidoreductases; Animals; Betaine; Betaine-Homocysteine S-Methyltransferase; Choline; Diet; Ethanol; Homocysteine; Humans; Liver; Methionine; Methotrexate; Methylation; Methyltransferases; Oxidation-Reduction; Rats; Tetrahydrofolates | 1983 |
The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders.
Topics: AIDS Dementia Complex; Animals; Brain Diseases; Dementia; Disease Models, Animal; Epilepsy; Humans; Metabolism, Inborn Errors; Methotrexate; Methylation; Multiple Sclerosis; Neurotransmitter Agents; Parkinson Disease; Receptors, Neurotransmitter; S-Adenosylmethionine; Spinal Cord Diseases | 1994 |
The mechanism of action of methotrexate.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Methotrexate; Methylation | 1997 |
Molecular and cellular effects of methotrexate.
Topics: Adenosine; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Humans; Methotrexate; Methylation | 1999 |
Methotrexate and Ras methylation: a new trick for an old drug?
Topics: Animals; Humans; Methotrexate; Methylation; Protein Processing, Post-Translational; ras Proteins | 2004 |
New mechanisms for an old drug; DHFR- and non-DHFR-mediated effects of methotrexate in cancer cells.
Topics: Antimetabolites, Antineoplastic; Cell Death; Cell Differentiation; Folic Acid; Folic Acid Antagonists; Histone Deacetylase Inhibitors; Humans; Methotrexate; Methylation; Nucleotides; Tetrahydrofolate Dehydrogenase | 2012 |
Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cell Adhesion Molecules; Cytokines; Eicosanoids; Folic Acid Antagonists; Humans; Metalloproteases; Methotrexate; Methylation; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Reactive Oxygen Species; Signal Transduction; Treatment Outcome | 2016 |
37 other study(ies) available for isomethyleugenol and methotrexate
Article | Year |
---|---|
Preparation of 6-(bromomethyl)-2,4-pteridinediamine hydrobromide and its use in improved syntheses of methotrexate and related compounds.
Topics: Bromine; Diamines; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methods; Methotrexate; Methylation; Pteridines | 1977 |
Choline antagonism of methotrexate liver toxicity in the rat.
Topics: Animals; Chemical and Drug Induced Liver Injury; Choline; Hydroxyurea; Liver; Liver Diseases; Male; Methotrexate; Methylation; Rats; Triglycerides | 1977 |
Inhibitory action of 10-deazaaminopterins and their polyglutamates on human thymidylate synthase.
Topics: Alkylation; Aminopterin; Humans; Kinetics; Leukemia, Myeloid, Acute; Methotrexate; Methylation; Peptides; Polyglutamic Acid; Structure-Activity Relationship; Thymidylate Synthase | 1986 |
Regulation of thymidylate synthetase activity in cultured mammalian cells.
Topics: Animals; Cell Division; Cells, Cultured; Cricetinae; Dactinomycin; Floxuridine; Methotrexate; Methylation; Protein Biosynthesis; Puromycin; Radiometry; RNA; Thymidine Kinase; Thymine Nucleotides; Transferases; Tritium; Uracil Nucleotides | 1972 |
Methylation of mammalian DNA: studies on Novikoff hepatoma cells in tissue culture.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Culture Techniques; Cytosine Nucleotides; DNA; Liver Neoplasms; Methionine; Methotrexate; Methylation; Neoplasms, Experimental; Purines; Pyrimidines; Rats; Thymine | 1969 |
Uptake of methotrexate, aminopterin, and methasquin and inhibition of dihydrofolate reductase and of DNA synthesis in mouse small intestine.
Topics: Aminopterin; Animals; Deoxyuridine; DNA; Dose-Response Relationship, Drug; Folic Acid Antagonists; Injections, Intravenous; Intestinal Mucosa; Intestine, Small; Male; Methotrexate; Methylation; Mice; Quinazolines | 1973 |
Uptake and reduction of radioactive folate by everted sacs of rat small intestine.
Topics: Animals; Biological Transport; Carbon Isotopes; Chromatography, DEAE-Cellulose; Folic Acid; Intestinal Absorption; Jejunum; Kinetics; Male; Methods; Methotrexate; Methylation; Oxidation-Reduction; Oxygen Consumption; Partial Pressure; Rats; Tetrahydrofolates | 1973 |
Effect of methylation inhibitors on fermentations of S. lincolnensis. Production of N-demethyllincomycin.
Topics: Aminobenzoates; Aminopterin; Aminosalicylic Acids; Benzoates; Chromatography, Thin Layer; Culture Media; Fermentation; Folic Acid Antagonists; Lincomycin; Methionine; Methotrexate; Methylation; Streptomyces; Sulfadiazine; Sulfaguanidine; Sulfanilamides; Sulfathiazoles; Sulfonamides | 1973 |
Properties of thymidylate synthetase from dichloromethotrexate-resistant Lactobacillus casei.
Topics: Drug Resistance, Microbial; Enzyme Activation; Escherichia coli; Folic Acid; Glutamates; Kinetics; Lactobacillus; Mercaptoethanol; Methotrexate; Methylation; Molecular Weight; Pteridines; Spectrophotometry; Transferases; Tritium; Uracil Nucleotides | 1970 |
A model system for the study of heteroexchange diffusion: methotrexate-folate interactions in L1210 leukemia and Ehrlich ascites tumor cells.
Topics: Animals; Binding Sites; Biological Transport; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell Line; Cell Membrane; Cells, Cultured; Chromatography, DEAE-Cellulose; Diffusion; Folic Acid; Folic Acid Antagonists; Formates; Kinetics; Leukemia L1210; Methotrexate; Methylation; Mice; Models, Biological; Tritium | 1971 |
Effects of perfusion with amethopterin on L1210 leukemia cells in spin filter culture.
Topics: Agar; Animals; Binding Sites; Cell Count; Cell Division; Centrifugation; Clone Cells; Culture Techniques; Deoxyuridine; DNA, Neoplasm; Leukemia L1210; Methods; Methotrexate; Methylation; Mice; Perfusion; Tetrahydrofolate Dehydrogenase; Time Factors; Transferases; Tritium; Uracil Nucleotides | 1970 |
Thymidylate synthetase from amethopterin-resistant Lactobacillus casei.
Topics: Acrylates; Benzoates; Chemical Precipitation; Chromatography, Gel; Chromatography, Ion Exchange; Crystallization; Cyanides; Detergents; Dialysis; Drug Resistance, Microbial; Electrophoresis; Electrophoresis, Disc; Ethylmaleimide; Folic Acid; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydroxyapatites; Iodoacetates; Kinetics; Lactobacillus; Magnesium; Mercury; Methotrexate; Methylation; Molecular Weight; Nucleotides; Quaternary Ammonium Compounds; Sulfates; Sulfhydryl Compounds; Sulfuric Acids; Transferases; Ultracentrifugation; Uracil Nucleotides | 1971 |
Methotrexate hepatotoxicity.
Topics: Animals; Betaine; Cholesterol Esters; Folic Acid; Homocysteine; Lipotropic Agents; Liver; Male; Methionine; Methotrexate; Methylation; Rats; Tetrahydrofolates; Triglycerides | 1984 |
The effect of methotrexate on homocysteine methylating agents in rat liver.
Topics: Animals; Betaine; Folic Acid Antagonists; Homocysteine; Liver; Male; Methotrexate; Methylation; Rats; Rats, Inbred Strains; Tetrahydrofolates; Time Factors | 1982 |
Regulation of folate-binding protein gene expression by DNA methylation in methotrexate-resistant KB cells.
Topics: Azacitidine; Blotting, Southern; Carrier Proteins; Decitabine; DNA, Neoplasm; Drug Resistance; Folate Receptors, GPI-Anchored; Gene Expression Regulation, Neoplastic; Humans; KB Cells; Methotrexate; Methylation; Receptors, Cell Surface; Transcription, Genetic | 1994 |
HIV-1 expression induced by anti-cancer agents in latently HIV-1-infected ACH2 cells.
Topics: Antineoplastic Agents; Azacitidine; Base Sequence; CD4-Positive T-Lymphocytes; Cell Line; Cell Survival; Cytarabine; DNA; Fluorouracil; HIV-1; Methotrexate; Methylation; Molecular Sequence Data; NF-kappa B; Phytohemagglutinins; Tetradecanoylphorbol Acetate; Vinblastine | 1995 |
Recovery of polyclonal hematopoiesis in patients with myelodysplastic syndromes following successful chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cytarabine; Female; Hematopoiesis; Humans; Methotrexate; Methylation; Middle Aged; Myelodysplastic Syndromes; Polymorphism, Restriction Fragment Length; Remission Induction | 1994 |
CpG island mapping of a mouse double-minute chromosome.
Topics: Animals; Cell Line; Chromosome Mapping; Drug Resistance; Extrachromosomal Inheritance; Gene Amplification; Methotrexate; Methylation; Mice; Restriction Mapping; Tetrahydrofolate Dehydrogenase | 1993 |
Choline deficiency and methotrexate treatment induces marked but reversible changes in hepatic folate concentrations, serum homocysteine and DNA methylation rates in rats.
Topics: Animals; Choline; Choline Deficiency; DNA Modification Methylases; Folic Acid; Folic Acid Antagonists; Homocysteine; Liver; Male; Methotrexate; Methylation; Rats; Rats, Wistar | 1995 |
Effects on transmethylation by high-dose 6-mercaptopurine and methotrexate infusions during consolidation treatment of acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Child; Erythrocytes; Homocysteine; Humans; Mercaptopurine; Methionine; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purine Nucleotides; S-Adenosylhomocysteine; S-Adenosylmethionine | 1996 |
Mechanisms of the effects of methotrexate.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Methylation; Rheumatoid Nodule | 1996 |
Folate depletion induced by methotrexate affects methionine synthase activity and its susceptibility to inactivation by nitrous oxide.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Anesthetics, Inhalation; Female; Folic Acid; Folic Acid Antagonists; Homocysteine; Humans; Methotrexate; Methylation; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12 | 1997 |
Increased concentrations of methylated 6-mercaptopurine metabolites and 6-thioguanine nucleotides in human leukemic cells in vitro by methotrexate.
Topics: Culture Media; Guanine Nucleotides; Humans; Mercaptopurine; Methotrexate; Methylation; Thioguanine; Tumor Cells, Cultured | 1998 |
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate.
Topics: Animals; Folic Acid Antagonists; Humans; Methotrexate; Methylation; Mice; Protein Methyltransferases; ras Proteins; S-Adenosylhomocysteine; Signal Transduction | 2003 |
Aberrant methylation in the promoter region of the reduced folate carrier gene is a potential mechanism of resistance to methotrexate in primary central nervous system lymphomas.
Topics: Adult; Aged; Antineoplastic Agents; Central Nervous System Neoplasms; CpG Islands; Drug Resistance, Neoplasm; Female; Humans; Lymphoma, Large B-Cell, Diffuse; Male; Membrane Transport Proteins; Methotrexate; Methylation; Middle Aged; Predictive Value of Tests; Prevalence; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA | 2004 |
Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Blotting, Western; Cells, Cultured; Immunohistochemistry; Methotrexate; Methylation; Neurons; Phosphorylation; Protein Phosphatase 2; Rats; tau Proteins; Time Factors | 2007 |
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity.
Topics: Adolescent; Cerebrospinal Fluid; Child; Child, Preschool; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
C1 metabolism and chlorophyll synthesis: the Mg-protoporphyrin IX methyltransferase activity is dependent on the folate status.
Topics: Arabidopsis; Carbon; Chlorophyll; Folic Acid; Light; Methotrexate; Methylation; Methyltransferases; Pisum sativum; Plant Leaves; Tetrahydrofolates | 2009 |
Methotrexate-associated alterations of the folate and methyl-transfer pathway in the CSF of ALL patients with and without symptoms of neurotoxicity.
Topics: Adolescent; Brain Infarction; Child; Child, Preschool; Demyelinating Diseases; Facial Paralysis; Female; Folic Acid; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Methylation; Neurotoxicity Syndromes; Paresis; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 2009 |
Suppression of antifolate resistance by targeting the myosin Va trafficking pathway in melanoma.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; E2F1 Transcription Factor; Enzyme Activation; Female; Gene Silencing; Humans; Melanoma; Methotrexate; Methylation; Mice; Myosin Heavy Chains; Myosin Type V; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2C; Protein Transport; Proto-Oncogene Proteins c-akt; Signal Transduction; Staurosporine; Xenograft Model Antitumor Assays | 2013 |
Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells.
Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Cytidine; DNA Modification Methylases; Drug Antagonism; Drug Resistance, Neoplasm; Drug Synergism; Humans; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Receptors, Aryl Hydrocarbon; Vincristine | 2014 |
The association between fasting hypoglycemia and methylated mercaptopurine metabolites in children with acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Blood Glucose; Child; Child, Preschool; Dexamethasone; Dietary Carbohydrates; Drug Administration Schedule; Fasting; Female; Guanine Nucleotides; Humans; Hyperglycemia; Hypoglycemia; Hypoxanthine Phosphoribosyltransferase; Infant; Liver Glycogen; Maintenance Chemotherapy; Male; Mercaptopurine; Methotrexate; Methylation; Methyltransferases; Polymorphism, Genetic; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Retrospective Studies; Thionucleotides | 2014 |
Lengthening of high-yield production levels of monoclonal antibody-producing Chinese hamster ovary cells by downregulation of breast cancer 1.
Topics: Animals; Antibodies, Monoclonal; BRCA1 Protein; CHO Cells; Clone Cells; Cricetinae; Cricetulus; Down-Regulation; Gene Amplification; Gene Silencing; Genes, BRCA1; Histones; In Situ Hybridization, Fluorescence; Methotrexate; Methylation; RNA, Small Interfering; Transfection; Transgenes | 2017 |
Canonical Wnt is inhibited by targeting one-carbon metabolism through methotrexate or methionine deprivation.
Topics: Carbon; Endosomes; Glycogen Synthase Kinase 3 beta; HEK293 Cells; HeLa Cells; Humans; Lysosomes; Methionine; Methotrexate; Methylation; Niacinamide; Protein-Arginine N-Methyltransferases; Repressor Proteins; S-Adenosylmethionine; Wnt Signaling Pathway | 2019 |
Methylation analysis of the SLC19A1 promoter region in Chinese children with acute lymphoblastic leukaemia.
Topics: Antimetabolites, Antineoplastic; Asian People; Child; Female; Humans; Male; Methotrexate; Methylation; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Reduced Folate Carrier Protein | 2020 |
Seropositivity-Dependent Association between LINE-1 Methylation and Response to Methotrexate Therapy in Early Rheumatoid Arthritis Patients.
Topics: Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Humans; Leukocytes, Mononuclear; Long Interspersed Nucleotide Elements; Methotrexate; Methylation; Prospective Studies; Treatment Outcome | 2022 |
Correlation between methylation level of the
Topics: Adult; Antimetabolites, Antineoplastic; Humans; Methotrexate; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Reduced Folate Carrier Protein; Retrospective Studies | 2023 |