isomethyleugenol has been researched along with levodopa in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (24.39) | 18.7374 |
| 1990's | 8 (19.51) | 18.2507 |
| 2000's | 11 (26.83) | 29.6817 |
| 2010's | 11 (26.83) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Matthysse, S | 1 |
| Bidard, JN; Cronenberger, L | 1 |
| Baldessarini, RJ; Lipinski, JF; Stramentinoli, G | 1 |
| Ordonez, LA; Wurtman, RJ | 1 |
| Goodwin, BL; King, GS; Ruthven, CR; Sandler, M | 1 |
| Bartholini, G; Haefely, W; Pletscher, A | 1 |
| Muenter, MD; Sharpless, NS; Tyce, GM | 1 |
| Cogoli-Greuter, M; Weinreich, R; Wiese, C; Winterhalter, KH | 1 |
| Hirose, S; Ishimitsu, T | 1 |
| Algeri, S; Catto, E; Stramentinoli, G | 1 |
| Jung, MJ; Palfreyman, MG; Ribéreau-Gayon, G; Wagner, J; Zraïka, M | 1 |
| Karhunen, T; Pavel, S; Slingerland, R; Smit, N; Tilgmann, C; Ulmanen, I; Westerhof, W | 1 |
| Fukazawa, H; Funaki, T; Kuruma, I; Onodera, H; Tagami, C; Tsukamoto, Y; Ushiyama, N | 1 |
| Julkunen, I; Lotta, T; Melén, K; Taskinen, J; Tilgmann, C; Ulmanen, I; Vidgren, J | 1 |
| Da Prada, M; Napolitano, A; Zürcher, G | 1 |
| Männistö, PT; Törnwall, M | 1 |
| Charlton, CG; Crowell, B | 1 |
| Joseph, JA; Miller, JW; Selhub, J | 1 |
| Charlton, CG; Liu, XX; Wilson, K | 1 |
| Bräutigam, C; Hoffman, GF; Hyland, K; Knust, A; Sharma, RK; Wevers, RA | 1 |
| Hainzl, D; Loureiro, AI; Parada, A; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Parada, A; Soares-da-Silva, P | 1 |
| Parada, A; Soares-da-Silva, P; Vieira-Coelho, MA | 1 |
| Decker, PA; Dousa, MK; Muenter, MD; Offord, KP; Tyce, GM; Weinshilboum, RM | 1 |
| Di Rocco, A; Werner, P | 1 |
| Brosnan, JT; Brosnan, ME; Jacobs, RL; Stead, LM | 2 |
| Bezard, E; Brotchie, JM; Fox, SH; Hallett, PJ; Lubin, FD; Nicholas, AP; Ravenscroft, P; Standaert, DG; Sweatt, JD; Vattem, P; Zhou, S | 1 |
| Bouchard, TP; Camicioli, RM; Somerville, MJ | 1 |
| Barone, P; De Bonis, ML; Galletti, P; Ingrosso, D; Longo, K; Pellecchia, MT; Russo, A; Salvatore, A; Tedeschi, G; Tessitore, A; Zappia, V | 1 |
| García-Horsman, JA; Käenmäki, M; Kambur, O; Karvonen, E; Keisala, T; Kulesskaya, N; Männistö, PT; Rauvala, H; Tammimäki, A | 1 |
| Bishop, SC; Fukui, M; Kang, KS; Wen, Y; Yamabe, N; Zhu, BT | 1 |
| Arning, E; Bottiglieri, T; Nunbhakdi-Craig, V; Sontag, E; Sontag, JM; Wasek, B | 1 |
| Fukui, M; Kang, KS; Wen, Y; Yamabe, N; Zhu, BT | 1 |
| Jia, YH; Zhu, X | 1 |
| Charlton, CG; Dent, L; Griffin, B; King, J; Mackey, V; Muthian, G; Smith, ML | 1 |
| Cao, L; Hao, H; Hao, K; Li, F; Liu, H; Qi, Q; Wang, H | 1 |
| Aonurm-Helm, A; Duran-Torres, G; Garcia-Horsman, A; Mannisto, PT; Poutanen, M; Tammimaki, A; Zhang, FP | 1 |
| Aonurm-Helm, A; Männistö, PT; Tammimäki, A | 1 |
| Jadavji, NM; Murray, LK | 1 |
| Birmingham, WR; Galman, JL; Parmeggiani, F; Seibt, L; Turner, NJ | 1 |
4 review(s) available for isomethyleugenol and levodopa
| Article | Year |
|---|---|
Monoaminergic drugs: general pharmacology.
Topics: Absorption; Amantadine; Amphetamine; Animals; Apomorphine; Brain; Catecholamines; Cats; Cattle; Deamination; Decarboxylation; Dogs; Half-Life; Haplorhini; Humans; Hydroxylation; Kinetics; Levodopa; Methylation; Mice; Rats | 1976 |
Methylation demand: a key determinant of homocysteine metabolism.
Topics: Animals; Creatine; Guanidinoacetate N-Methyltransferase; Homocysteine; Humans; Levodopa; Methylation; Methyltransferases; Models, Biological; Models, Chemical; Parkinson Disease; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Rats | 2004 |
Methylation demand and homocysteine metabolism.
Topics: Animals; Homocysteine; Humans; Levodopa; Methionine Adenosyltransferase; Methylation; Methyltransferases; Niacin; Phosphatidylethanolamine N-Methyltransferase; S-Adenosylmethionine | 2004 |
The role of one-carbon metabolism and homocysteine in Parkinson's disease onset, pathology and mechanisms.
Topics: Animals; Diet; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Levodopa; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; One-Carbon Group Transferases; Parkinson Disease; Polymorphism, Genetic; Vitamin B Complex | 2019 |
37 other study(ies) available for isomethyleugenol and levodopa
| Article | Year |
|---|---|
On lowering S-adenosylmethionine.
Topics: Animals; Levodopa; Liver; Methylation; Methyltransferases; Niacinamide; Norepinephrine; Rats; S-Adenosylmethionine | 1978 |
[Fluorimetric assay of 3-o-methyldopamine and 4-0-methyldopamine in rat urine and o-methylation of dopamine].
Topics: Animals; Deoxyepinephrine; Dopamine; Levodopa; Male; Methylation; Rats; S-Adenosylmethionine; Spectrometry, Fluorescence | 1977 |
Methylation hypothesis.
Topics: Adult; Animals; Brain; Dose-Response Relationship, Drug; Female; Humans; Levodopa; Liver; Lung; Male; Methionine; Methylation; Mice; Rabbits; Rats; S-Adenosylmethionine; Tryptamines | 1979 |
Effects of exogenous L-dopa on the metabolism of methionine and S-adenosylmethionine in the brain.
Topics: Animals; Brain; Levodopa; Methionine; Methylation; Rats; S-Adenosylmethionine | 1978 |
Metabolism of 3, 4-dihydroxyphenylalanine, its metabolites and analogues in vivo in the rat: urinary excretion pattern.
Topics: Alcohols; Amines; Amino Acids; Animals; Biotransformation; Carboxylic Acids; Levodopa; Male; Methylation; Rats | 1978 |
Effect of L-DOPA on endogenous histamine metabolism.
Topics: Acetates; Adult; Aged; Animals; Carbidopa; Depression, Chemical; Female; Guinea Pigs; Histamine; Humans; Imidazoles; Levodopa; Male; Methylation; Middle Aged; Parkinson Disease; Rats; Species Specificity | 1975 |
Comparative metabolism of fluorinated 3,4-dihydroxyphenylalanine isomers in aggregating brain cell cultures.
Topics: Animals; Brain; Cell Aggregation; Cells, Cultured; Decarboxylation; Dihydroxyphenylalanine; Levodopa; Methylation; Stereoisomerism | 1992 |
Determination of m- and p-O-methylated products of L-3,4-dihydroxyphenylalanine using high-performance liquid chromatography and electrochemical detection.
Topics: Animals; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Isomerism; Levodopa; Liver; Methylation; Parkinson Disease; Rats; Rats, Inbred Strains; Tyrosine | 1985 |
Decrease of noradrenaline O-methylation in rat brain induced by L-dopa. Reversal effect of S-adenosyl-L-methionine.
Topics: Animals; Brain; Levodopa; Male; Methoxyhydroxyphenylglycol; Methylation; Norepinephrine; Rats; S-Adenosylmethionine | 1980 |
Irreversible inhibition of aromatic-L-amino acid decarboxylase by alpha-difluoromethyl-DOPA and metabolism of the inhibitor.
Topics: Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Catechol O-Methyltransferase; Dihydroxyphenylalanine; Kidney; Levodopa; Methylation; Methyldopa; Pyridoxal Phosphate; Rats; Swine | 1980 |
O-methylation of L-dopa in melanin metabolism and the presence of catechol-O-methyltransferase in melanocytes.
Topics: 1-Methyl-3-isobutylxanthine; Catechol O-Methyltransferase; Cells, Cultured; Humans; Isoenzymes; Levodopa; Melanins; Melanocytes; Melanoma; Membrane Proteins; Methylation; Microscopy, Immunoelectron; Monophenol Monooxygenase; Neoplasm Proteins; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1994 |
Lack of an effect of Madopar on the disposition of tolcapone and its 3-O-methylated metabolite in rats.
Topics: Animals; Benserazide; Benzophenones; Biotransformation; Catechol O-Methyltransferase Inhibitors; Drug Combinations; Enzyme Inhibitors; Half-Life; Injections, Intravenous; Levodopa; Male; Methylation; Nitrophenols; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Tissue Distribution; Tolcapone | 1995 |
Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme.
Topics: Animals; Base Sequence; Catechol O-Methyltransferase; Cell Membrane; Dopamine; Enzyme Stability; Hot Temperature; Humans; Hydroxybenzoates; Kinetics; Levodopa; Magnesium; Methylation; Models, Molecular; Molecular Sequence Data; Norepinephrine; Rats; Recombinant Proteins; S-Adenosylmethionine | 1995 |
Effects of tolcapone, a novel catechol-O-methyltransferase inhibitor, on striatal metabolism of L-dopa and dopamine in rats.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benserazide; Benzophenones; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Extracellular Space; Homovanillic Acid; Levodopa; Male; Methylation; Microdialysis; Neostriatum; Nitrophenols; Rats; Tolcapone | 1995 |
Effects of three types of catechol O-methylation inhibitors on L-3,4-dihydroxyphenylalanine-induced circling behaviour in rats.
Topics: Amidines; Amphetamine; Animals; Behavior, Animal; Benzophenones; Carbidopa; Catechol O-Methyltransferase Inhibitors; Catechols; Clorgyline; Drug Interactions; Drug Synergism; Levodopa; Male; Methylation; Nitriles; Nitrophenols; Pyridones; Rats; Rats, Wistar; Tolcapone | 1993 |
Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism.
Topics: Animals; Antiparkinson Agents; Caudate Nucleus; Dopamine; Dose-Response Relationship, Drug; Hypokinesia; Injections, Intraventricular; Levodopa; Male; Methylation; Motor Activity; Neostriatum; Parkinson Disease; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Tremor | 1995 |
Oxidative damage caused by free radicals produced during catecholamine autoxidation: protective effects of O-methylation and melatonin.
Topics: Catecholamines; Copper Sulfate; Deoxyepinephrine; Dopamine; Free Radicals; Levodopa; Melatonin; Methylation; Oxidation-Reduction; Phycoerythrin; Spectrometry, Fluorescence; Tyrosine | 1996 |
Effects of L-dopa treatment on methylation in mouse brain: implications for the side effects of L-dopa.
Topics: Animals; Antiparkinson Agents; Brain Chemistry; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dopamine; Dose-Response Relationship, Drug; Levodopa; Male; Methionine Adenosyltransferase; Methylation; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Spectrophotometry, Ultraviolet | 2000 |
The influence of L-dopa on methylation capacity in aromatic L-amino acid decarboxylase deficiency: biochemical findings in two patients.
Topics: Amino Acid Metabolism, Inborn Errors; Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Hypokinesia; Levodopa; Methoxyhydroxyphenylglycol; Methylation; Muscle Hypotonia; Tetrahydrofolates; Tyrosine | 2000 |
BIA 3-202, a novel catechol-O-methyltransferase inhibitor, enhances the availability of L-DOPA to the brain and reduces its O-methylation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Acetophenones; Animals; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Corpus Striatum; Dihydroxyphenylalanine; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Homovanillic Acid; Levodopa; Male; Methylation; Rats; Rats, Wistar; Time Factors; Tyrosine | 2001 |
BIA 3-202, a novel catechol-O-methyltransferase inhibitor, reduces the peripheral O-methylation of L-DOPA and enhances its availability to the brain.
Topics: Acetophenones; Animals; Antiparkinson Agents; Biological Availability; Brain; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dopamine; Dose-Response Relationship, Drug; Levodopa; Liver; Male; Methylation; Microdialysis; Rats; Rats, Wistar | 2003 |
Catechol-O-methyltransferase inhibition in erythrocytes and liver by BIA 3-202 (1-[3,4-dibydroxy-5-nitrophenyl]-2-phenyl-ethanone).
Topics: Acetophenones; Administration, Oral; Animals; Antiparkinson Agents; Benserazide; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Chromatography, High Pressure Liquid; Corpus Striatum; Dihydroxyphenylalanine; Drug Interactions; Erythrocytes; Humans; In Vitro Techniques; Levodopa; Liver; Methylation; Methyldopa; Microdialysis; Rats; Rats, Wistar | 2003 |
L-DOPA biotransformation: correlations of dosage, erythrocyte catechol O-methyltransferase and platelet SULT1A3 activities with metabolic pathways in Parkinsonian patients.
Topics: Adenosine Diphosphate; Aged; Arylsulfotransferase; Biotransformation; Blood Platelets; Carbidopa; Catechol O-Methyltransferase; Dose-Response Relationship, Drug; Drug Combinations; Erythrocytes; Female; Humans; Levodopa; Male; Methylation; Middle Aged; Parkinson Disease; S-Adenosylmethionine; Sulfates | 2003 |
Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status.
Topics: Antiparkinson Agents; Homocysteine; Humans; Hyperhomocysteinemia; Levodopa; Methylation; Parkinson Disease; S-Adenosylmethionine; Vitamin B Complex | 2004 |
Striatal histone modifications in models of levodopa-induced dyskinesia.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Acetylation; Animals; Chromatin; Chromosome Aberrations; Corpus Striatum; Disease Models, Animal; Dopamine Agents; Dyskinesia, Drug-Induced; Extracellular Signal-Regulated MAP Kinases; Female; Histones; Levodopa; Macaca mulatta; Male; Methylation; Mice; Mice, Inbred C57BL; Parkinsonian Disorders; Phosphorylation; Protein Processing, Post-Translational; Species Specificity | 2008 |
Homocysteine is not associated with global motor or cognitive measures in nondemented older Parkinson's disease patients.
Topics: Aged; Antiparkinson Agents; Cognition; Creatinine; Female; Folic Acid; Genotype; Homocysteine; Humans; Inactivation, Metabolic; Levodopa; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Motor Skills; Neuropsychological Tests; Parkinson Disease; Severity of Illness Index; Vitamin B Complex | 2009 |
Impaired transmethylation potential in Parkinson's disease patients treated with L-Dopa.
Topics: Aged; Antiparkinson Agents; Cross-Sectional Studies; Erythrocytes; Female; Genotype; Homocysteine; Humans; Levodopa; Male; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Parkinson Disease; Polymorphism, Genetic; S-Adenosylhomocysteine; S-Adenosylmethionine | 2010 |
Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Behavior, Animal; Brain; Carbidopa; Catechol O-Methyltransferase; Dopamine; Drug Combinations; Extracellular Space; Female; Levodopa; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Mutation; Phenotype; Sensory Gating; Sex Factors; Social Dominance | 2010 |
Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies.
Topics: Animals; Biological Products; Catechin; Catechol O-Methyltransferase Inhibitors; Cell Death; Cell Line; Enzyme Inhibitors; Hippocampus; Humans; Kainic Acid; Levodopa; Male; Methylation; Mice; Neurons; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2010 |
Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain.
Topics: Animals; Antiparkinson Agents; Brain; Cell Line, Tumor; Dopaminergic Neurons; Humans; Levodopa; Male; Methylation; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroblastoma; Phosphorylation; Primary Cell Culture; Protein Phosphatase 2; tau Proteins | 2012 |
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Antiparkinson Agents; Carbidopa; Catechin; Catechol O-Methyltransferase; Chromatography, High Pressure Liquid; Dihydroxyphenylalanine; Disease Models, Animal; Excitatory Amino Acid Agonists; Fluoresceins; Glial Fibrillary Acidic Protein; Hippocampus; Hydroxybenzoates; In Vitro Techniques; Kainic Acid; Levodopa; Male; Methylation; Mice; Nerve Degeneration; Neurons; Rats; Rats, Sprague-Dawley; Reserpine; Time Factors; Tyrosine | 2013 |
Inhibition of catechol-o-methyltransferase (COMT) by myricetin, dihydromyricetin, and myricitrin.
Topics: Catechol O-Methyltransferase Inhibitors; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flavonoids; Flavonols; Humans; Indicators and Reagents; Kinetics; Levodopa; Liver; Methylation; Structure-Activity Relationship | 2014 |
Effects of acute and sub-chronic L-dopa therapy on striatal L-dopa methylation and dopamine oxidation in an MPTP mouse model of Parkinsons disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antiparkinson Agents; Catechol O-Methyltransferase; Corpus Striatum; Disease Models, Animal; Dopamine; Drug Administration Schedule; Levodopa; Male; Methylation; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Parkinsonian Disorders; Time Factors | 2014 |
Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats.
Topics: Animals; Benzofurans; Benzophenones; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Kinetics; Levodopa; Male; Metabolome; Methylation; Nitrophenols; Organ Specificity; Rats, Sprague-Dawley; Reproducibility of Results; Substrate Specificity; Tolcapone; Tyrosine | 2015 |
Generation of membrane-bound catechol-O-methyl transferase deficient mice with disctinct sex dependent behavioral phenotype.
Topics: Animals; Behavior, Animal; Brain; Catechol O-Methyltransferase; Dopamine; Female; Intracellular Membranes; Levodopa; Male; Memory, Short-Term; Methylation; Mice; Mice, Inbred C57BL; Motor Activity; Phenotype | 2016 |
Delayed O-methylation of l-DOPA in MB-COMT-deficient mice after oral administration of l-DOPA and carbidopa.
Topics: Animals; Carbidopa; Catechol O-Methyltransferase; Levodopa; Methylation; Mice; Mice, Mutant Strains | 2018 |
One-Pot Biocatalytic In Vivo Methylation-Hydroamination of Bioderived Lignin Monomers to Generate a Key Precursor to L-DOPA.
Topics: Biocatalysis; Levodopa; Lignin; Methylation; Methyltransferases; Molecular Structure | 2022 |