isomethyleugenol has been researched along with dextromethorphan in 26 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (50.00) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dun-Ren, P; Ladona, MG; Lindström, B; Rane, A; Thyr, C | 1 |
| Reichen, J; Roos, FJ; Zysset, T | 1 |
| Bochner, F; Kerry, NL; Mikus, G; Somogyi, AA | 2 |
| Gorski, JC; Hall, SD; Jones, DR; Wrighton, SA | 1 |
| Cresteil, T; Funck-Brentano, C; Jacqz-Aigrain, E | 1 |
| Beaune, P; Dayer, P; Lecoeur, S; Leemann, T; Transon, C | 1 |
| Fogelman, SM; Greenblatt, DJ; Schmider, J; Shader, RI; von Moltke, LL | 1 |
| Agúndez, JA; Albet, C; Benítez, J; Carrillo, JA; Herrero, E; Márquez, M; Martínez, C; Ortiz, JA | 1 |
| Ariyoshi, N; Chida, M; Kamataki, T; Kobayashi, S; Mizorogi, Y; Tateishi, T | 1 |
| Abdel-Rahman, SM; Boge, T; Gotschall, RR; Kearns, GL; Leeder, JS; Marcucci, K | 1 |
| Charvátová, Z; Hadasová, E; Hykosová, M; Nerusilová, K; Zelenková, O | 1 |
| Bertino, JS; Gaedigk, A; Gotschall, R; Kashuba, AD; Kearns, GL; Leeder, JS; Nafziger, AN | 1 |
| Bechtel, PR; Bechtel, Y; Berard, M; Haffen, E; Masuyer, C; Paintaud, G | 1 |
| Huang, W; Moody, DE; Nelson, AC | 1 |
| Hagiwara, M; Inoue, Y; Kawashima, Y; Someya, T | 1 |
| Di Marco, A; Laufer, R; Yao, D | 1 |
| Iga, T; Ishiguro, A; Ishikawa, H; Kubota, T | 1 |
| Lutz, RW; Lutz, U; Lutz, WK; Völkel, W | 1 |
| Chiappe, A; Cottini, S; Daali, Y; Dayer, P; Desmeules, J; Fathi, M; Gasche, Y | 1 |
| Jung, HJ; Kim, HS; Lee, SJ; Lee, SS; Park, SJ; Shin, JG; Yeo, CW | 1 |
| Abd-Rashid, BA; Er, HM; Ismail, R; Ismail, Z; Mak, JW; Ong, CE; Pan, Y; Pook, PC | 1 |
| Kadota, S; Takahashi, N; Tezuka, Y | 1 |
| Bae, JS; Hong, M; Jee, JG; Jeong, TC; Lee, MY; Lee, S; Lee, YM; Song, M | 1 |
| Hieftje, GM; Mielczarek, P; Reszke, E; Silberring, J; Smoluch, M | 1 |
| Bitter, W; Commandeur, JNM; Geerke, DP; Luirink, RA; Ortega Ugalde, S; Vermeulen, NPE | 1 |
1 trial(s) available for isomethyleugenol and dextromethorphan
| Article | Year |
|---|---|
Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists.
Topics: Adult; Anti-Anxiety Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Benzenesulfonates; Caffeine; Central Nervous System Stimulants; Cimetidine; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Double-Blind Method; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Methylation; Microsomes, Liver; Midazolam; Oxidoreductases, N-Demethylating; Psychomotor Performance; Ranitidine; Thiazoles | 1999 |
25 other study(ies) available for isomethyleugenol and dextromethorphan
| Article | Year |
|---|---|
Differential foetal development of the O- and N-demethylation of codeine and dextromethorphan in man.
Topics: Antibodies, Monoclonal; Blotting, Western; Chromatography, High Pressure Liquid; Codeine; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Dextromethorphan; Embryonic and Fetal Development; Humans; Methylation; Microsomes, Liver; Midazolam; Mixed Function Oxygenases | 1991 |
Differential effect of biliary and micronodular cirrhosis on oxidative drug metabolism. In vivo-in vitro correlations of dextromethorphan metabolism in rat models.
Topics: Animals; Body Weight; Dextromethorphan; Dextrorphan; Liver Cirrhosis; Liver Cirrhosis, Biliary; Male; Metabolic Clearance Rate; Methylation; Microsomes, Liver; Models, Biological; Organ Size; Oxidoreductases, O-Demethylating; Rats; Rats, Inbred Strains; Spleen | 1991 |
The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.
Topics: Autoantibodies; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Dextropropoxyphene; Dextrorphan; Humans; In Vitro Techniques; Methadone; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Perhexiline; Phenotype; Quinidine | 1994 |
Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily.
Topics: Adult; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Humans; In Vitro Techniques; Kinetics; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Phenotype | 1994 |
CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans.
Topics: Adult; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Fetus; Humans; In Vitro Techniques; Kinetics; Male; Methylation; Microsomes, Liver; Mixed Function Oxygenases | 1993 |
Primary and secondary oxidative metabolism of dextromethorphan. In vitro studies with female Sprague-Dawley and Dark Agouti rat liver microsomes.
Topics: Animals; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Isoenzymes; Kinetics; Methylation; Microsomes, Liver; Oxidation-Reduction; Phenotype; Rats; Rats, Sprague-Dawley | 1993 |
Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes.
Topics: Adult; Age Factors; Anesthetics, Intravenous; Animals; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Cyclooxygenase Inhibitors; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; Female; Humans; Hydroxylation; Isoenzymes; Male; Methylation; Mice; Microsomes, Liver; Midazolam; Mixed Function Oxygenases; Rabbits; Regression Analysis; Sex Factors; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; White People | 1996 |
Metabolism of dextromethorphan in vitro: involvement of cytochromes P450 2D6 and 3A3/4, with a possible role of 2E1.
Topics: Animals; Antitussive Agents; Benzoflavones; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Ditiocarb; Enzyme Inhibitors; Humans; In Vitro Techniques; Methylation; Microsomes, Liver; Mixed Function Oxygenases; Quinidine; Rats; Sulfaphenazole; Tissue Donors | 1997 |
Analysis of the CYP2D6 gene in relation to dextromethorphan O-demethylation capacity in a Japanese population.
Topics: Adult; Alleles; Asian People; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dextromethorphan; Genotype; Humans; Japan; Male; Methylation; Oxidoreductases, O-Demethylating; Phenotype; Polymerase Chain Reaction; Reference Values | 1999 |
Potent inhibition of cytochrome P-450 2D6-mediated dextromethorphan O-demethylation by terbinafine.
Topics: Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Enzyme Inhibitors; Humans; Methylation; Microsomes, Liver; Models, Molecular; Naphthalenes; Terbinafine | 1999 |
Influence of pretreatment with immunosuppressants on O-demethylation of dextromethorphan in isolated perfused rat liver.
Topics: Alcohol Oxidoreductases; Animals; Aryl Hydrocarbon Hydroxylases; Chromatography, High Pressure Liquid; Cyclophosphamide; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Dexamethasone; Dextromethorphan; Dextrorphan; Immunosuppressive Agents; Kinetics; Liver; Male; Methylation; Rats; Rats, Wistar | 1999 |
Limitations of dextromethorphan N-demethylation as a measure of CYP3A activity.
Topics: Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Female; Genotype; Humans; Male; Methylation; Oxidoreductases, N-Demethylating; Phenotype | 1999 |
On the assessment of drug metabolism by assays of codeine and its main metabolites.
Topics: Adult; Chromatography, High Pressure Liquid; Codeine; Cytochrome P-450 CYP2D6; Debrisoquin; Dextromethorphan; Female; Glucuronides; Humans; Linear Models; Male; Methylation; Middle Aged; Morphine; Phenotype; Polymorphism, Genetic; Reproducibility of Results; Sensitivity and Specificity | 2000 |
Variables in human liver microsome preparation: impact on the kinetics of l-alpha-acetylmethadol (LAAM) n-demethylation and dextromethorphan O-demethylation.
Topics: Adolescent; Adult; Biomarkers; Cell Fractionation; Centrifugation; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Kinetics; Male; Methadyl Acetate; Methylation; Microsomes, Liver; Middle Aged; Smoking; Substance-Related Disorders; Sucrose | 2001 |
Evaluation of dextromethorphan N-demethylation activity as a biomarker for cytochrome P450 3A activity in man.
Topics: Adult; Aryl Hydrocarbon Hydroxylases; Biomarkers; Cytochrome P-450 CYP3A; Dextromethorphan; Humans; Male; Metabolic Clearance Rate; Methylation; Midazolam; Middle Aged; Oxidoreductases, N-Demethylating; Sensitivity and Specificity | 2002 |
Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.
Topics: Animals; Benzoflavones; Carbon Radioisotopes; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Enzyme Inhibitors; Hepatocytes; Inhibitory Concentration 50; Kinetics; Male; Methylation; Microsomes, Liver; Oxidoreductases, O-Demethylating; Protein Binding; Quinidine; Quinine; Rats; Rats, Sprague-Dawley; Sulfaphenazole; Troleandomycin | 2003 |
Metabolic activity of dextromethorphan O-demethylation in healthy Japanese volunteers carrying duplicated CYP2D6 genes: duplicated allele of CYP2D6*10 does not increase CYP2D6 metabolic activity.
Topics: Adult; Biotransformation; Cytochrome P-450 CYP2D6; Dextromethorphan; Dextrorphan; Female; Gene Dosage; Gene Duplication; Genotype; Humans; Japan; Male; Methylation; Middle Aged; Pharmacogenetics | 2004 |
LC-MS/MS analysis of dextromethorphan metabolism in human saliva and urine to determine CYP2D6 phenotype and individual variability in N-demethylation and glucuronidation.
Topics: Chromatography, Liquid; Cytochrome P-450 CYP2D6; Dextromethorphan; Glucuronides; Humans; Mass Spectrometry; Methylation; Phenotype; Saliva | 2004 |
Codeine intoxication associated with ultrarapid CYP2D6 metabolism.
Topics: Analgesics, Opioid; Antitussive Agents; Codeine; Cough; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Genotype; Humans; Lung Diseases, Fungal; Male; Methylation; Middle Aged; Phenotype; Pneumonia | 2004 |
Discovery of novel functional variants and extensive evaluation of CYP2D6 genetic polymorphisms in Koreans.
Topics: 5' Untranslated Regions; Adult; Aryl Hydrocarbon Hydroxylases; Asian People; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2D6; Dextromethorphan; DNA Mutational Analysis; Female; Gene Frequency; Genetic Variation; Genetics, Population; Genotype; Humans; Male; Methylation; Oxidoreductases, N-Demethylating; Phenotype; Polymorphism, Genetic; Polymorphism, Single Nucleotide | 2009 |
In vitro modulatory effects on three major human cytochrome P450 enzymes by multiple active constituents and extracts of Centella asiatica.
Topics: Aryl Hydrocarbon Hydroxylases; Centella; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dealkylation; Dextromethorphan; Dose-Response Relationship, Drug; Enzyme Inhibitors; Herb-Drug Interactions; Humans; Hydroxylation; Kinetics; Methylation; Pentacyclic Triterpenes; Plant Extracts; Recombinant Proteins; Substrate Specificity; Testosterone; Tolbutamide; Triterpenes | 2010 |
Mechanism-based CYP2D6 inactivation by acridone alkaloids of Indonesian medicinal plant Lunasia amara.
Topics: Acridines; Acridones; Alkaloids; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Dose-Response Relationship, Drug; Herb-Drug Interactions; Humans; Indonesia; Liver; Methylation; Microsomes; NADP; Plant Extracts; Plants, Medicinal; Rutaceae | 2012 |
Selective inhibition of the cytochrome P450 isoform by hyperoside and its potent inhibition of CYP2D6.
Topics: Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextromethorphan; Drug Discovery; Enzyme Inhibitors; Galactosides; Herb-Drug Interactions; Humans; Isoenzymes; Kinetics; Methylation; Microsomes, Liver; Oenanthe; Quercetin; Recombinant Proteins | 2013 |
Determination of psychostimulants and their metabolites by electrochemistry linked on-line to flowing atmospheric pressure afterglow mass spectrometry.
Topics: Anti-Inflammatory Agents; Atmospheric Pressure; Benzydamine; Central Nervous System Stimulants; Cytochrome P-450 Enzyme System; Dextromethorphan; Electrochemical Techniques; Equipment Design; Excitatory Amino Acid Antagonists; Humans; Mass Spectrometry; Metabolic Networks and Pathways; Methamphetamine; Methylation; Oxidation-Reduction | 2014 |
Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium.
Topics: Bacillus megaterium; Bacterial Proteins; Catalysis; Cloning, Molecular; Cytochrome P-450 Enzyme System; Dextromethorphan; Gene Fusion; Humans; Inhibitory Concentration 50; Kinetics; Methylation; Molecular Docking Simulation; Molecular Dynamics Simulation; Mycobacterium tuberculosis; NADPH-Ferrihemoprotein Reductase; Oxidation-Reduction; Recombinant Fusion Proteins; Substrate Specificity | 2018 |