isomethyleugenol has been researched along with caffeine in 68 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 29 (42.65) | 18.7374 |
| 1990's | 14 (20.59) | 18.2507 |
| 2000's | 18 (26.47) | 29.6817 |
| 2010's | 6 (8.82) | 24.3611 |
| 2020's | 1 (1.47) | 2.80 |
| Authors | Studies |
|---|---|
| Suzuki, T; Takahashi, E | 2 |
| Wong, JL; Zady, MF | 1 |
| Boutroy, MJ; Monin, P; Royer, RJ; Royer-Morrot, MJ; Vert, P | 1 |
| Suzuki, T | 1 |
| Aldridge, A; Aranda, JV; Haber, R; Louridas, AT; Thom, P; Vitullo, BB | 1 |
| Ido, T; Iwata, R; Kasida, Y; Saji, H; Suzuki, K; Tamate, K; Yoshikawa, K | 1 |
| Kihlman, BA; Sturelid, S | 1 |
| Dusci, LJ; Hackett, LP; McDonald, IA | 1 |
| Hoffman, J; Lindberg, B; Painter, T | 1 |
| Kumar, R; Mende, P; Preussmann, R; Siddiqi, M; Spiegelhalder, B; Wacker, CD | 1 |
| Ishikawa, A; Kobayashi, S; Misawa, S; Tanaka, E; Uchida, E; Yamamoto, Y; Yasuhara, H | 1 |
| Battula, N; Doehmer, J; Fuhr, U; Keita, Y; Kudla, C; Staib, AH; Wölfel, C | 1 |
| Ihara, T; Kurishita, A | 1 |
| Neri, G; Zollino, M | 1 |
| Roberts, JJ; Sturrock, JE | 1 |
| Brogger, A | 1 |
| Jenne, JW; Nagasawa, HT; Thompson, RD | 1 |
| Fujii, T; Nishimura, H | 1 |
| Cornish, HH; Khanna, KL; Rao, GS | 1 |
| Campiglio, A | 1 |
| de Bree, PK; Haverkamp, J; van der Heiden, C; van Gennip, AH; Vliegenthart, JF; Wadman, SK | 1 |
| Luckner, M | 1 |
| Boucher, EA; Horning, EC; Horning, MG; Stafford, M | 1 |
| Burg, AW; Stein, ME | 1 |
| Burg, AW; Werner, E | 1 |
| Kalsner, S | 1 |
| Dehn, F; LeValley, SE; Lombrozo, L; Mitoma, C | 1 |
| Haley, TJ | 1 |
| Boon, MH; Parsons, PG | 1 |
| Carricarte, VC; Kelley, MR; Owens, JG; Sega, GA | 1 |
| Brazier, JL; Desage, M; Renaud, H; Ribon, B; Salle, B | 1 |
| Arnaud, MJ; Preisig, R; Renner, EL; Schaad, HJ; Wietholtz, H | 1 |
| Alm, C; Benitez, J; Bertilsson, L; Bondesson, U; Carrillo, JA; Dahl, ML; Lindström, L; Llerena, A; Ramos, S; Rodriguez de la Rubia, I | 1 |
| Brösicke, H; Heinemeyer, G; Roots, I; Rost, KL | 1 |
| Girre, C; Padoin, C; Palombo, S; Rizzo, N; Scherrmann, JM | 1 |
| Brśen, K; Jeppesen, U; Loft, S; Poulsen, HE | 1 |
| Danielson, TJ; Golsteyn, LR | 1 |
| Brøsen, K; Rasmussen, BB | 1 |
| Cha, YN; Chung, WG; Kim, HM; Roh, HK | 1 |
| Bulitta, J; Dammeyer, J; Fuhr, U; Kinzig-Schippers, M; Labedzki, A; Rüsing, G; Sörgel, F; Zaigler, M | 1 |
| Agúndez, JA; Albet, C; Benítez, J; Carrillo, JA; Herrero, E; Márquez, M; Martínez, C; Ortiz, JA | 1 |
| Iakovlev, SV; Iakovlev, VP | 1 |
| Ashihara, H; Crozier, A; Kato, A; Koshiishi, C; Yama, S | 1 |
| Choo, EF; Mayo, G; Shyr, Y; Sofowora, GG; Wilkinson, GR | 1 |
| Golor, G; Hagenmaier, H; Köner, W; Neubert, D; Yamashita, K | 1 |
| Ashihara, H; Crozier, A | 1 |
| Ashihara, H; Crozier, A; Kato, M; Ye, CX; Zheng, XQ | 1 |
| Grand, F; Guitton, J; Kilinc, I; Sarkis, A | 1 |
| Abraham, K; Bauer, S; Brockmöller, J; Geusau, A; Helge, H; Tosun, Y | 1 |
| Koscheski, P; Noel, JP; Pichersky, E; Ross, JR; Yang, Y; Zubieta, C | 1 |
| Cejka, P; Di Pietro, M; Ferrari, S; Jiricny, J; Marra, G; Mojas, N; Stojic, L | 1 |
| Ascherio, A; Brown-Jermyn, D; Chen, JF; Dluzen, DE; Schwarzschild, MA; Xu, K; Xu, Y | 1 |
| Brøsen, K; Damkier, P; Grandjean, P; Halling, J; Nielsen, F; Petersen, MS; Weihe, P | 1 |
| Cannon, CL; Coughenour, M; Crosby, SD; Durmus, S; Ely, DL; Hindi, K; Hogue, LA; Hovis, CE; Kascatan-Nebioglu, A; Mallett, RJ; Melaiye, A; Milsted, A; Panzner, MJ; Tessier, CA; Youngs, WJ | 1 |
| Burke, V; Hodgson, JM; Puddey, IB; van Bockxmeer, FM | 1 |
| Kodama, Y; Sano, H; Shinya, T | 1 |
| Pawlukojc, A; Prager, M; Wischnewski, A; Wuttke, J | 1 |
| Daniel, WA; Kot, M | 1 |
| Brody, SL; Cannon, CL; Capps, GH; Hindi, KM; Hogue, LA; Ibricevic, A; Kascatan-Nebioglu, A; Vajravelu, RK; Walter, MJ; Youngs, WJ | 1 |
| Cheng, HY; Lee, SC; Liu, SY; Wu, SS; Yan, RH | 1 |
| Cao, H; Chen, L; Cu, F; Deng, Y; Lei, Y; Liu, J; Magdalou, J; Tan, Y; Wang, H; Wu, M; Xu, D | 1 |
| Alnahhas, RN; Bachman, JL; Barrick, JE; Dasgupta, A; Hammerling, MJ; Otoupal, PB; Quandt, EM; Slater, B; Subramanian, MV; Summers, RM | 1 |
| Fujino, H; Hosaka, S; Iwasaki, K; Murayama, N; Onose, Y; Shimizu, M; Uno, Y; Utoh, M; Yamazaki, H | 1 |
| Guo, H; Yue, Y | 1 |
| da Silva, JF; Gonçalves, JF; Kiyota, E; Mayer, JL; Mazzafera, P; Schimpl, FC | 1 |
| Bao, GH; Deng, WW; Ho, CT; Ling, TJ; Wan, XC; Wang, P; Wang, W; Wu, FH; Zhang, P; Zhang, ZZ; Zhu, BY | 1 |
| Abe, I; Cao, ZQ; Ding, K; Duan, WJ; Gong, HB; He, RR; Hu, D; Kurihara, H; Li, YF; Lu, X; Ouyang, SH; Sun, WY; Tan, L; Wang, Y; Xie, C; Xie, G; Zhang, YH; Zhang, ZM | 1 |
4 review(s) available for isomethyleugenol and caffeine
| Article | Year |
|---|---|
Biosynthesis of purine nucleotides and methylated purines in higher plants.
Topics: Antimetabolites; Biodegradation, Environmental; Caffeine; Methylation; Plants; Purine Nucleotides; Purines | 1977 |
[On new studies of the biosynthesis of N-heterocyclic compounds. 5. Formation and decomposition of substances with purine, pteridine, and benzopteridine ring systems].
Topics: Allantoin; Caffeine; Folic Acid; Heterocyclic Compounds; Methylation; Oxidation-Reduction; Pteridines; Purines; Pyrimidines; Theobromine | 1966 |
Metabolism and pharmacokinetics of theophylline in human neonates, children, and adults.
Topics: Adult; Age Factors; Apnea; Asthma; Biotransformation; Bradycardia; Caffeine; Child; Female; Half-Life; Humans; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Kinetics; Male; Methylation; Pulmonary Edema; Theophylline; Tissue Distribution | 1983 |
[Pharmacokinetic interactions between fluoroquinolones and methylxanthines].
Topics: Anti-Infective Agents; Caffeine; Drug Interactions; Fluoroquinolones; Humans; Methylation; Theophylline; Xanthines | 1999 |
5 trial(s) available for isomethyleugenol and caffeine
| Article | Year |
|---|---|
Clozapine disposition covaries with CYP1A2 activity determined by a caffeine test.
Topics: Administration, Oral; Arylamine N-Acetyltransferase; Caffeine; Chromatography, High Pressure Liquid; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Humans; Methylation; Oxidoreductases; Sweden; Xanthine Oxidase | 1994 |
Omeprazole and lansoprazole are not inducers of cytochrome P4501A2 under conventional therapeutic conditions.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Adult; Anti-Ulcer Agents; Caffeine; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Female; Humans; Hydroxylation; Lansoprazole; Male; Methylation; Middle Aged; Omeprazole; Oxidoreductases; Proton Pump Inhibitors | 1996 |
A fluvoxamine-caffeine interaction study.
Topics: Adult; Biotransformation; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Fluvoxamine; Half-Life; Humans; Methylation; Reference Values; Selective Serotonin Reuptake Inhibitors | 1996 |
Interaction of pefloxacin and enoxacin with the human cytochrome P450 enzyme CYP1A2.
Topics: Adult; Anti-Infective Agents; Area Under Curve; Caffeine; Central Nervous System Stimulants; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Drug Interactions; Enoxacin; Female; Humans; Male; Methylation; Microsomes, Liver; Pefloxacin; Reference Values | 1999 |
Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists.
Topics: Adult; Anti-Anxiety Agents; Antitussive Agents; Aryl Hydrocarbon Hydroxylases; Benzenesulfonates; Caffeine; Central Nervous System Stimulants; Cimetidine; Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dextromethorphan; Double-Blind Method; Histamine H2 Antagonists; Humans; In Vitro Techniques; Male; Methylation; Microsomes, Liver; Midazolam; Oxidoreductases, N-Demethylating; Psychomotor Performance; Ranitidine; Thiazoles | 1999 |
59 other study(ies) available for isomethyleugenol and caffeine
| Article | Year |
|---|---|
Further investigation of the biosynthesis of caffeine in tea plants (Camellia sinensis L.). Methylation of transfer ribonucleic acid by tea leaf extracts.
Topics: Caffeine; Dithiothreitol; Hydrogen-Ion Concentration; Metals; Methylation; Quaternary Ammonium Compounds; RNA, Transfer; Tea; tRNA Methyltransferases | 1976 |
Kinetics and mechanism of carbon-8 methylation of purine bases and nucleosides by methyl radical.
Topics: Adenine; Adenosine; Caffeine; Guanine; Guanosine; Hot Temperature; Hydrogen-Ion Concentration; Hypoxanthines; Inosine; Kinetics; Methods; Methylation; Photochemistry; Purine Nucleosides | 1977 |
Methylation of theophylline to caffeine in premature infants.
Topics: Apnea; Biotransformation; Caffeine; Humans; Infant, Newborn; Infant, Premature, Diseases; Methylation; Theophylline; Xanthines | 1979 |
Metabolism of theophylline to caffeine in human fetal liver.
Topics: Apnea; Biotransformation; Caffeine; Cells, Cultured; Gestational Age; Humans; Infant, Newborn; Liver; Methylation; Theophylline | 1979 |
[Caffeine-11C, ephedrine-11C and methylephedrine-11C: Synthesis and distribution in mice (author's transl)].
Topics: Animals; Caffeine; Carbon Radioisotopes; Ephedrine; Isotope Labeling; Male; Methylation; Mice; Phenylpropanolamine; Theophylline; Time Factors; Tissue Distribution | 1978 |
Enhancement by methylated oxypurines of the frequency of induced chromosomal aberrations.
Topics: Animals; Caffeine; Cell Line; Cells, Cultured; Chromosome Aberrations; Chromosomes; Cricetinae; Drug Synergism; Methylation; Mutation; Plants; Purines; Theobromine; Theophylline; Thiotepa; Uric Acid | 1975 |
Metabolism of methionine and biosynthesis of caffeine in the tea plant (Camellia sinensis L.).
Topics: Adenosine Monophosphate; Caffeine; Glycine; Guanine Nucleotides; Methionine; Methylation; Nucleic Acids; Serine; Tea; Time Factors; Xanthines | 1976 |
Gas-liquid chromatographic determination of theophylline in human plasma.
Topics: Caffeine; Chromatography, Gas; Hot Temperature; Humans; Methods; Methylation; Microchemistry; Theophylline | 1975 |
The structure of guaran.
Topics: Caffeine; Galactose; Mannose; Methylation; Polysaccharides; Time Factors | 1975 |
Caffeine-derived N-nitroso compounds--I: Nitrosatable precursors from caffeine and their potential relevance in the etiology of oesophageal and gastric cancers in Kashmir, India.
Topics: Bicarbonates; Caffeine; Esophageal Neoplasms; Humans; Hydrogen-Ion Concentration; India; Methylation; Nitroso Compounds; Risk Factors; Sodium; Sodium Bicarbonate; Sodium Chloride; Stomach Neoplasms; Tea | 1992 |
Simplified approach for evaluation of hepatic drug-oxidizing capacity with a simultaneous measurement of caffeine and its primary demethylated metabolites in carbon tetrachloride-intoxicated rats.
Topics: Administration, Oral; Animals; Caffeine; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Evaluation Studies as Topic; Liver; Liver Diseases; Male; Methylation; Oxidation-Reduction; Rats; Rats, Sprague-Dawley | 1992 |
Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms.
Topics: Animals; Biotransformation; Caffeine; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cytochrome P-450 Enzyme System; Genetic Engineering; Humans; Hydroxylation; Methylation; Mice; Rats; Species Specificity; Theophylline; Xanthines | 1992 |
Inhibitory effect of caffeine on 5-azacytidine-induced digital malformations in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Azacitidine; Caffeine; Dose-Response Relationship, Drug; Female; Fetal Death; Limb Deformities, Congenital; Methylation; Pregnancy; Rats | 1987 |
Protective effect of S-adenosylmethionine against the induction of chromosome fragile sites.
Topics: Caffeine; Chromosome Fragile Sites; Chromosome Fragility; DNA Damage; Floxuridine; Humans; Lymphocytes; Methylation; S-Adenosylmethionine | 1987 |
Enhancement by caffeine of N-methyl-N-nitrosourea-induced mutations and chromosome aberrations in Chinese hamster cells.
Topics: Animals; Azaguanine; Caffeine; Cells, Cultured; Chromosome Aberrations; Cricetinae; DNA; Dose-Response Relationship, Drug; Drug Synergism; Female; Mesylates; Methylation; Mutation; Nitrosoguanidines; Nitrosourea Compounds; Ovary; Time Factors | 1973 |
Caffeine-induced enhancement of chromosome damage in human lymphocytes treated with methyl-methanesulphonate, mitomycin C and X-rays.
Topics: Autoradiography; Binding Sites; Caffeine; Carbon Radioisotopes; Chromatids; Chromosome Aberrations; Chromosomes; DNA; DNA Repair; DNA Replication; Drug Synergism; Humans; In Vitro Techniques; Lymphocytes; Mesylates; Methylation; Mitomycins; Mutagens; Nucleic Acid Hybridization; Radiation Genetics; Tritium | 1974 |
Determination of theophylline and its metabolites in human urine and serum by high-pressure liquid chromatography.
Topics: Administration, Oral; Aminophylline; Caffeine; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Ion Exchange; Humans; Hypoxanthines; Methylation; Pressure; Theophylline; Uric Acid; Xanthines | 1974 |
Fetal hypoproteinemia associated with generalized edema caused by administration of methyl xanthines to the rat during late pregnancy.
Topics: Animals; Blood Proteins; Body Water; Body Weight; Caffeine; Edema; Female; Fetal Diseases; Fetus; Gestational Age; Hypoproteinemia; Methylation; Pregnancy; Rats; Theobromine; Theophylline; Xanthines | 1973 |
Mass spectrometric identification of methylxanthines and methyluric acids, the possible metabolites of caffeine.
Topics: Caffeine; Chromatography, Gas; Mass Spectrometry; Methods; Methylation; Theobromine; Theophylline; Uric Acid; Xanthines | 1972 |
[Determination of the N-methyl group in organic substances on the micro and decimomilligram scale].
Topics: Acetanilides; Aminopyrine; Antipyrine; Caffeine; Diphenhydramine; Ephedrine; Indicators and Reagents; Methylation; Microchemistry; Theobromine; Theophylline | 1973 |
Urinary excretion of 3 -methylxanthine and related compounds in children.
Topics: Adolescent; Adult; Cacao; Caffeine; Child; Child, Preschool; Chromatography, Ion Exchange; Chromatography, Paper; Coffee; Diet; Humans; Infant; Intellectual Disability; Mass Spectrometry; Methylation; Neuromuscular Diseases; Spectrophotometry, Ultraviolet; Stereoisomerism; Tea; Theobromine; Theophylline; Xanthines | 1973 |
A rapid procedure for the isolation of drugs and drug metabolites from plasma.
Topics: 1-Propanol; Animals; Caffeine; Carbon Isotopes; Carbonates; Chromatography, Gas; Chromatography, Thin Layer; Fatty Acids; Humans; Mass Spectrometry; Methods; Methylation; Phenobarbital; Potassium; Rats; Silicon | 1972 |
Urinary excretion of caffeine and its metabolites in the mouse.
Topics: Animals; Caffeine; Carbon Dioxide; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Feces; Humans; Kinetics; Male; Methylation; Mice; Mice, Inbred Strains; Tritium; Uric Acid; Water; Xanthines | 1972 |
Tissue distribution of caffeine and its metabolites in the mouse.
Topics: Animals; Brain; Caffeine; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Erythrocytes; Half-Life; Kinetics; Liver; Lung; Male; Methylation; Mice; Mice, Inbred Strains; Muscles; Myocardium; Nucleotides; Spleen; Testis; Tritium; Uric Acid; Xanthines | 1972 |
Mechanism of potentiation of contractor responses to catecholamines by methylxanthines in aortic strips.
Topics: Animals; Aorta; Caffeine; Catecholamines; Cycloparaffins; Drug Synergism; Epinephrine; In Vitro Techniques; Ketones; Methoxamine; Methylation; Muscle Contraction; Muscle, Smooth; Norepinephrine; Normetanephrine; Phenylephrine; Propiophenones; Pyrogallol; Rabbits; Reserpine; Synephrine; Theophylline; Xanthines | 1971 |
Nature of the effect of caffeine on the drug-metabolizing enzymes.
Topics: 17-Hydroxycorticosteroids; Acetanilides; Amino Acids; Aminopyrine; Aniline Compounds; Animals; Caffeine; Cytochromes; Dactinomycin; Drug Antagonism; Enzyme Induction; Female; Humans; Male; Methylation; Microsomes, Liver; Oxidoreductases; Phenobarbital; Pregnanes; Pyridones; Rats; Stimulation, Chemical; Time Factors; Zoxazolamine | 1969 |
Cyclophosphamide resistance developed in a human melanoma cell line.
Topics: Benzamides; Caffeine; Cell Line; Cross-Linking Reagents; Cyclophosphamide; Drug Resistance; Humans; Melanoma; Methylation; Microsomes, Liver | 1984 |
Caffeine pretreatment enhances the unscheduled DNA synthesis in spermatids of mice exposed to methyl methanesulfonate.
Topics: Caffeine; DNA; DNA Repair; Drug Synergism; Male; Methyl Methanesulfonate; Methylation; Spermatids | 1983 |
In vivo N7 methylation of theophylline to caffeine in premature infants. Studies with use of stable isotopes.
Topics: Caffeine; Carbon Isotopes; Humans; Infant, Newborn; Infant, Premature; Methylation; Nitrogen Isotopes; Phenobarbital; Theophylline; Time Factors | 1981 |
Caffeine demethylation measured by breath analysis in experimental liver injury in the rat.
Topics: Animals; Breath Tests; Caffeine; Carbon Dioxide; Carbon Radioisotopes; Liver Diseases; Male; Methylation; Rats; Rats, Sprague-Dawley; Respiration | 1995 |
Specific and dose-dependent enzyme induction by omeprazole in human beings.
Topics: Absorption; Adolescent; Adult; Aged; Aged, 80 and over; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Female; gamma-Glutamyltransferase; Glutarates; Half-Life; Humans; Hydrocortisone; Male; Mephenytoin; Methylation; Middle Aged; Omeprazole; Oxidoreductases | 1994 |
Systemic clearance and demethylation of caffeine in sheep and cattle.
Topics: Animals; Caffeine; Cattle; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Female; Half-Life; Methylation; Reference Standards; Sheep | 1996 |
Theophylline has no advantages over caffeine as a putative model drug for assessing CYPIA2 activity in humans.
Topics: Adult; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP1A2; Humans; Male; Metabolic Clearance Rate; Methylation; Microsomes, Liver; Phosphodiesterase Inhibitors; Theophylline | 1997 |
Involvement of CYP3A1, 2B1, and 2E1 in C-8 hydroxylation and CYP 1A2 and flavin-containing monooxygenase in N-demethylation of caffeine; identified by using inducer treated rat liver microsomes that are characterized with testosterone metabolic patterns.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Induction; Hydroxylation; In Vitro Techniques; Male; Methylation; Methylcholanthrene; Microsomes, Liver; Mixed Function Oxygenases; Oxygenases; Rats; Rats, Sprague-Dawley; Testosterone; Thioamides | 1998 |
A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-L-methionine cycle.
Topics: Adenosine; Adenosylhomocysteinase; Caffeine; Carbon Dioxide; Cell Extracts; Chloroplasts; Homocysteine; Hydrolases; Methionine Adenosyltransferase; Methylation; Plant Leaves; S-Adenosylhomocysteine; S-Adenosylmethionine; Tea; Theobromine | 2001 |
In vivo inhibition of human CYP1A2 activity by oltipraz.
Topics: Adult; Antineoplastic Agents; Caffeine; Cytochrome P-450 CYP1A2 Inhibitors; Enzyme Inhibitors; Female; Humans; Male; Methylation; Pyrazines; Theophylline; Thiones; Thiophenes | 2001 |
Kinetics and inductive potency of 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin (H7CDD) in rats.
Topics: Animals; Breath Tests; Caffeine; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Enzyme Induction; Female; Half-Life; Metabolic Clearance Rate; Methylation; Microsomes, Liver; Polychlorinated Dibenzodioxins; Rats; Rats, Wistar; Time Factors; Tissue Distribution | 2001 |
Caffeine: a well known but little mentioned compound in plant science.
Topics: Biotechnology; Caffeine; Cloning, Molecular; Coffee; Gram-Negative Bacteria; Methylation; Methyltransferases; Plant Leaves; Recombinant Proteins; Species Specificity; Tea | 2001 |
Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha).
Topics: Adenosine; Alkaloids; Beverages; Caffeine; Camellia; Carbon Radioisotopes; Methylation; Molecular Structure; Plant Leaves; Staining and Labeling; Time Factors; Uric Acid | 2002 |
Application of isotopic ratio mass spectrometry for the in vitro determination of demethylation activity in human liver microsomes using N-methyl-13C-labeled substrates.
Topics: Aminopyrine; Caffeine; Carbon Isotopes; Cytochrome P-450 Enzyme System; Erythromycin; Humans; In Vitro Techniques; Mass Spectrometry; Methylation; Microsomes, Liver; Oxidoreductases, N-Demethylating | 2002 |
Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction.
Topics: Adult; Breath Tests; Caffeine; Case-Control Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Enzyme Induction; Female; Humans; Liver; Male; Methylation; Polychlorinated Dibenzodioxins; Smoking; Teratogens; Theophylline; Uracil; Uric Acid; Xanthines | 2002 |
Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family.
Topics: Amino Acid Sequence; Arabidopsis; Caffeine; Catalytic Domain; Clarkia; Crystallography, X-Ray; Indoleacetic Acids; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Conformation; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 2003 |
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase.
Topics: Ataxia Telangiectasia Mutated Proteins; Base Pair Mismatch; Caffeine; Cell Cycle; Cell Cycle Proteins; Cell Line; Checkpoint Kinase 1; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; G2 Phase; Histones; Humans; Methylation; Methylnitronitrosoguanidine; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Replication Protein A; Signal Transduction; Staurosporine; Tumor Suppressor Proteins | 2004 |
Estrogen prevents neuroprotection by caffeine in the mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Age Factors; Animals; Caffeine; Corpus Striatum; Cytochrome P-450 CYP1A2; Dopamine; Drug Implants; Estradiol; Estrogen Replacement Therapy; Female; Male; Methylation; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Ovariectomy; Parkinsonian Disorders; Sex Characteristics | 2006 |
Caffeine N3-demethylation (CYP1A2) in a population with an increased exposure to polychlorinated biphenyls.
Topics: Administration, Oral; Adolescent; Adult; Biometry; Caffeine; Cohort Studies; Cytochrome P-450 CYP1A2; Environmental Pollutants; Female; Genotype; Humans; Male; Methylation; Middle Aged; Polychlorinated Biphenyls; Sex Factors; Smoking; Uracil; Uric Acid; Xanthines | 2006 |
Synthesis from caffeine of a mixed N-heterocyclic carbene-silver acetate complex active against resistant respiratory pathogens.
Topics: Acetates; Animals; Anti-Bacterial Agents; Antifungal Agents; Caffeine; Cells, Cultured; Crystallography, X-Ray; Cystic Fibrosis; Drug Resistance, Bacterial; Drug Resistance, Fungal; Gene Expression; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Methylation; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Molecular Structure; Organometallic Compounds; Respiratory Mucosa; Respiratory Tract Infections; Silver Compounds; Structure-Activity Relationship | 2006 |
Acute effects of tea on fasting and non-fasting plasma total homocysteine concentrations in human subjects.
Topics: Aged; Biomarkers; Caffeine; Cross-Over Studies; Drinking; Eating; Fasting; Female; Flavonoids; Folic Acid; Gallic Acid; Homocysteine; Humans; Male; Methylation; Middle Aged; Phenols; Polyphenols; Tea; Vitamin B 12 | 2007 |
Dimerization of N-methyltransferases involved in caffeine biosynthesis.
Topics: Bacterial Proteins; Caffeine; Dimerization; DNA, Complementary; Luminescent Proteins; Methylation; Methyltransferases | 2008 |
Inelastic neutron scattering study of methyl groups rotation in some methylxanthines.
Topics: Caffeine; Methylation; Models, Chemical; Models, Molecular; Neutron Diffraction; Rotation; Spectrum Analysis; Theobromine; Theophylline; Thermodynamics; Xanthines | 2007 |
The relative contribution of human cytochrome P450 isoforms to the four caffeine oxidation pathways: an in vitro comparative study with cDNA-expressed P450s including CYP2C isoforms.
Topics: Caffeine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; DNA, Complementary; Humans; Methylation; Microsomes, Liver; Oxidation-Reduction; Protein Isoforms | 2008 |
In vitro and murine efficacy and toxicity studies of nebulized SCC1, a methylated caffeine-silver(I) complex, for treatment of pulmonary infections.
Topics: Animals; Anti-Bacterial Agents; Caffeine; Cell Line; Disease Models, Animal; Male; Methane; Methylation; Mice; Mice, Inbred C57BL; Pseudomonas aeruginosa; Pseudomonas Infections; Respiratory Tract Infections; Silver Compounds | 2009 |
Screen and genetic assessment of tea germplasms with elevated methylated catechin, (-)-epigallocatechin-3-O-(3-O-methyl)gallate.
Topics: Breeding; Caffeine; Camellia sinensis; Catechin; Methylation; Phylogeny; Plant Leaves; Species Specificity; Taiwan | 2009 |
Caffeine-induced fetal rat over-exposure to maternal glucocorticoid and histone methylation of liver IGF-1 might cause skeletal growth retardation.
Topics: Animals; Caffeine; Central Nervous System Stimulants; Female; Femur; Fetal Development; Fetal Growth Retardation; Fetal Weight; Gene Expression Regulation, Developmental; Glucocorticoids; Growth Plate; Histones; Insulin-Like Growth Factor I; Liver; Male; Maternal Exposure; Maternal-Fetal Exchange; Methylation; Pregnancy; Rats; Rats, Wistar; RNA, Messenger | 2012 |
Decaffeination and measurement of caffeine content by addicted Escherichia coli with a refactored N-demethylation operon from Pseudomonas putida CBB5.
Topics: Bacterial Proteins; Beverages; Biosensing Techniques; Caffeine; Escherichia coli; Genome, Bacterial; Glutathione Transferase; Guanine; Methylation; Multigene Family; Operon; Plasmids; Pseudomonas putida; Xanthine; Xanthines | 2013 |
Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline.
Topics: Animals; Caffeine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Haplorhini; Humans; Hydroxylation; Liver; Metabolic Networks and Pathways; Methylation; Microsomes, Liver; Molecular Docking Simulation; Oxidation-Reduction; Recombinant Proteins; Theophylline | 2013 |
Quantum mechanical/molecular mechanical study of catalytic mechanism and role of key residues in methylation reactions catalyzed by dimethylxanthine methyltransferase in caffeine biosynthesis.
Topics: Biocatalysis; Caffeine; Methylation; Methyltransferases; Models, Molecular; Protein Conformation; Quantum Theory; Thermodynamics; Xanthine | 2014 |
Molecular and biochemical characterization of caffeine synthase and purine alkaloid concentration in guarana fruit.
Topics: Alkaloids; Amino Acid Sequence; Base Sequence; Caffeine; Fruit; Methylation; Methyltransferases; Molecular Structure; Paullinia; Plant Leaves; Purines; Seeds; Theobromine; Theophylline; Xanthines | 2014 |
Enantiomeric Trimethylallantoin Monomers, Dimers, and Trimethyltriuret: Evidence for an Alternative Catabolic Pathway of Caffeine in Tea Plant.
Topics: Caffeine; Dimerization; Methylation; Models, Molecular; Molecular Conformation; Stereoisomerism; Tea | 2019 |
Identification and characterization of N9-methyltransferase involved in converting caffeine into non-stimulatory theacrine in tea.
Topics: Binding Sites; Biosynthetic Pathways; Caffeine; Cloning, Molecular; Crystallography, X-Ray; Evolution, Molecular; Gene Expression Regulation, Plant; Methylation; Methyltransferases; Plant Leaves; Recombinant Proteins; Tea; Transcription, Genetic; Uric Acid | 2020 |