isomethyleugenol has been researched along with adenosine in 1022 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 179 (17.51) | 18.7374 |
| 1990's | 70 (6.85) | 18.2507 |
| 2000's | 57 (5.58) | 29.6817 |
| 2010's | 275 (26.91) | 24.3611 |
| 2020's | 441 (43.15) | 2.80 |
| Authors | Studies |
|---|---|
| Wong, JL; Zady, MF | 1 |
| Darzynkiewicz, E; Dudycz, L; Ekiel, I; Shugar, D | 1 |
| Agris, PF; Armstrong, DJ; Schäfer, KP; Söll, D | 1 |
| Cartenì-Farina, M; De Rosa, M; Gambacorta, A; Napolitano, G; Oliva, A; Romeo, G; Zappia, V | 1 |
| Moss, B; Wei, CM | 1 |
| Gershowitz, A; Moss, B; Wei, CM | 1 |
| Abraham, G; Banerjee, AK; Rhodes, DP | 1 |
| Abraham, G; Adler, R; Banerjee, AK; Moyer, SA | 1 |
| Bishop, DH; Dubin, DT; Hefti, E; Stollar, V | 1 |
| Banerjee, AK; Moyer, SA | 1 |
| Dimock, K; Stoltzfus, CM | 1 |
| Gershowitz, A; Holland, LE; Moss, B; Stringer, JR; Wagner, EK | 1 |
| Lawrence, F; Pierré, A; Richou, M; Robert-Géro, M; Vigier, P | 1 |
| Aloni, Y; Carmi, P; Groner, Y | 1 |
| Hershfield, MS; Kredich, NM | 2 |
| Aloni, Y; Dhar, R; Khoury, G | 1 |
| Hayon, E; Moorthy, PN | 1 |
| Glazer, RI; Peale, AL | 2 |
| Furuichi, Y; Miura, K; Shimotohno, K | 1 |
| Mertens, PP; Payne, CC | 1 |
| Nishimura, S; Noguchi, S; Ramakrishnan, T; Taya, Y; Vani, BR; Yamaizumi, Z | 1 |
| Johnston, JM; Kredich, NM | 1 |
| Green, M; Hashimoto, S | 1 |
| Chen-Kiang, S; Darnell, JE; Nevins, JR | 1 |
| Carter, CA | 1 |
| Darnell, JE; Lavi, U; Sommer, S | 1 |
| Arnold, HH; Kersten, H; Schmidt, W | 1 |
| Keisel, N; Vold, B | 1 |
| Vold, B | 1 |
| Baglioni, C; Gershowitz, A; Moss, B; Weber, LA | 1 |
| Boone, RF; Moss, B | 1 |
| Darzynkiewicz, E; Dudycz, L; Ekiel, I; Rudzińska, A; Shugar, D | 1 |
| Lee, AS; MacCoss, M; Robins, MJ | 1 |
| Darzynkiewicz, E; Kazimierczuk, Z; Shugar, D | 1 |
| Nemer, M; Surrey, S | 1 |
| Duchastel, A; Faust, M; Fromson, D; Millward, S | 1 |
| Desai, LS; Foley, GE; Heuer, R; Meissner, J; Wulff, UC | 1 |
| Lin, RL; Narasimhachari, N | 1 |
| Chheda, GB; Chu, J; Wainfan, E | 1 |
| Munns, TW; Sims, HF | 1 |
| Gershowitz, A; Moss, B; Wei, C | 1 |
| Friderici, K; Kelley, DE; Perry, RP; Rottman, F | 1 |
| Narayan, P; Rottman, FM | 2 |
| McClelland, M; Nelson, M | 1 |
| Ackerman, JJ; Buttz, HR; Duerre, JA | 1 |
| Bowlin, TL; Davis, GF; Edwards, ML; Jarvi, ET; McCarthy, JR; Prakash, NJ | 1 |
| Mita, M | 1 |
| Kiss, A; Szilák, L; Venetianer, P | 1 |
| Agabian, N; McNally, KP | 1 |
| Aarbakke, J; Andersen, A; Loennechen, T; Moens, U; Nilsen, IW | 1 |
| Davie, JR; Hendzel, MJ | 1 |
| Hirota, K; Kitade, Y; Maki, Y; Nakata, Y; Pabuccuoglu, A; Torrence, PF | 1 |
| Barbes, C; Hardisson, C; Martin, CG; Sanchez, J; Yebra, MJ | 1 |
| Carter, C; Clarke, S; Damore, MA; Law, RE; Stimmel, JB; Wall, R | 1 |
| Aswad, DW; Johnson, BA; Najbauer, J | 3 |
| Borot, C; Lawrence, F; Moulay, L; Phelouzat, MA; Robert-Gero, M; Schaeverbeke, J; Schaeverbeke, M | 1 |
| Haklai, R; Kloog, Y | 1 |
| Kim, BR; Yang, KH | 1 |
| Chagoya de Sánchez, V; Hernández-Muñoz, R; Sánchez, L; Suárez, J; Vidrio, S; Yáñez, L | 1 |
| Borders, DB; Carter, GT; Greenstein, M; Maiese, WM; Nietsche, JA; Pearce, CJ | 1 |
| Carney, DF; Papadimitriou, JC; Shin, ML | 1 |
| Cañada, FJ; Pérez-Sala, D; Rando, RR; Tan, EW | 1 |
| Bourbonnière, M; Nalbantoglu, J | 1 |
| Bacchi, CJ; Quamina, A; Yarlett, N | 1 |
| Cordier, G; Fonlupt, P; Gormand, F; Pacheco, Y; Revillard, JP | 1 |
| Bergerat, A; Guschlbauer, W | 1 |
| Aarbakke, J; Prytz, PS | 1 |
| Borchardt, RT; Kramer, DL; Porter, CW; Sufrin, JR | 1 |
| Aswad, DW; Najbauer, J | 1 |
| Carroll, SM; Narayan, P; Rottman, FM | 1 |
| Friedman, S; Som, S | 1 |
| Bjorndahl, JM; Rutledge, CO | 1 |
| Dalaker, K; Prydz, H | 1 |
| Benyon, RC; Church, MK; Hughes, PJ | 1 |
| Lefort, J; Randon, J; Vargaftig, BB | 1 |
| Akedo, H; Horai, T; Inoue, H; Mukai, M; Nishikawa, S; Ohigashi, H; Shinkai, K; Takeda, Y | 1 |
| Ammann, AJ | 1 |
| Chelsky, D; O'Neill, CL; Sobotka, C | 1 |
| Borchardt, RT; Hasobe, M; McKee, JG | 1 |
| Cronstein, BN; Hirschhorn, R; Kramer, SB; Rosenstein, ED; Weissmann, G | 1 |
| Kerbel, RS; Liteplo, RG | 1 |
| Beemon, K; Kane, SE | 2 |
| Allen, ER; Freese, E; Orrego, C; Wabiko, H | 1 |
| Coulby, JN; Sternberg, N | 1 |
| Liteplo, RG | 1 |
| Deussen, A; Lloyd, HG; Schrader, J; Wuppermann, H | 1 |
| Kontinen, VP; Pispa, JP | 1 |
| Borchardt, RT; Keller, BT | 1 |
| Hoffman, JL; McConnell, KP | 1 |
| Ayers, DF; Maroney, PA; Narayan, P; Nilsen, TW; Rottman, FM | 1 |
| Ruby, C; Schulman, MD; Streicher, S; Valentino, D | 1 |
| Germain, BJ; O'Connor, CM | 1 |
| Finbloom, DS; Gordon, RK; Martin, J | 1 |
| Granoff, A; Thompson, JP; Willis, DB | 1 |
| Ayers, DF; Narayan, P; Nilsen, TW; Ransohoff, RM; Rottman, FM | 1 |
| Chan, VL; Ho, HJ; Skinner, MA | 1 |
| Loo, G; Smith, JT | 1 |
| Clarke, S; Lou, LL | 1 |
| Backlund, PS; Cantoni, GL; Carotti, D | 1 |
| Lawrence, F; Lederer, F; Paolantonacci, P; Robert-Gero, M | 1 |
| Glazer, RI; Haines, DR; Knode, MC; Marquez, VE; Tseng, CK | 1 |
| Cohen, MB; Glazer, RI; Hartman, KD; Knode, MC; Linevsky, J | 1 |
| Kufe, DW; Shafman, TD; Sherman, ML; Spriggs, DR | 1 |
| Silverstein, SC; Sung, SJ | 1 |
| Godeau, F; Ishizaka, T; Koide, SS | 1 |
| Samet, MK | 1 |
| Johnston, GC; Li, AW; Singer, RA | 1 |
| Ryder, NS | 1 |
| Borchardt, RT; Clark, RS; Keller, BT; Pegg, AE | 1 |
| Carson, DA; Iizasa, T | 1 |
| Abeles, RH; Chisholm, J; Fish, S; Tashjian, AH; Wolfson, G | 1 |
| Saito, T; Yamaguchi, J | 1 |
| Lechner, J; Sumper, M; Wieland, F | 1 |
| Hirayama, T; Kato, I; Matsuda, F; Noda, M | 1 |
| Carnegie, PR; Jones, GM | 1 |
| Arnold, H; Kersten, H | 1 |
| Kyogoku, Y; Yu, BS | 1 |
| Kerr, SJ | 1 |
| Merits, I | 1 |
| Baxter, CS; Byvoet, P | 2 |
| Desrosiers, R; Friderici, K; Rottman, F | 1 |
| Kleihues, P; Margison, GP; Mende, C; Patzschke, K; Wegner, LA | 1 |
| Fehler, SW; Light, RJ | 1 |
| Gross, HJ; Wildenauer, D | 1 |
| Weber, MJ | 1 |
| Ceccato, S; Passeri, M | 1 |
| Chang, SH; Munninger, KO | 1 |
| Harada, F; Nishimura, S; Oashi, Z; Saneyoshi, M | 1 |
| Landsberg, B; Wainfan, E | 1 |
| Blanchard, P; Farrugia, G; Hildesheim, J; Hildesheim, R; Michelot, R | 1 |
| Isham, KR; Stulberg, MP | 1 |
| Gross, HJ; Riesner, D; Wildenauer, D | 1 |
| Cier, JF; Pérès, G; Peyrin, L | 1 |
| Janion, C | 1 |
| Baudry, M; Chast, F; Schwartz, JC | 1 |
| Klootwijk, J; Planta, RJ | 1 |
| Lombardini, JB; Talalay, P | 1 |
| Cerutti, PA; Pleiss, MG | 1 |
| Brawerman, G; Lee, SY; Mendecki, J | 1 |
| Coward, JK; Sweet, WD | 1 |
| Gasbarrini, G; Labò, G; Miglio, F | 1 |
| Pfleger, K; Roos, H | 1 |
| Coward, JK; D'Urso-Scott, M; Sweet, WD | 1 |
| Chheda, GB; Mittelman, A | 1 |
| Chan, SI; Crawford, JE; Schweizer, MP | 1 |
| Brookes, P; Dipple, A; Mackintosh, DS; Rayman, MP | 1 |
| Hecht, SM | 1 |
| Naik, SR; Robins, MJ | 1 |
| Fredholm, BB; Jondal, M; Lanefelt, F; Ng, J | 1 |
| McGee, R; Rabe, CS | 1 |
| Abbasi, MM; Beisler, JA; Glazer, RI; Peale, AL | 1 |
| Glazer, RI; Hartman, KD | 2 |
| Groner, Y; Kahana, C; Revel, M; Yakobson, E | 1 |
| Chiang, PK; Morita, Y; Siraganian, RP | 1 |
| Morita, Y; Siraganian, RP | 1 |
| Ahl, R | 1 |
| Adams, JK; Allan, RG; Cooper, IA; Woodcock, DM | 1 |
| Hoffman, RM | 1 |
| Benyon, RC; Church, MK; Holgate, ST | 1 |
| Bardin, CW; Gagnon, C | 1 |
| Robert-Géro, M; Vedel, M | 1 |
| Pike, MC; Snyderman, R | 2 |
| Mizel, D; Pick, E | 1 |
| Cronstein, BN; Hirschhorn, R; Kramer, SB; Weissmann, G | 1 |
| Finkel, D; Groner, Y | 1 |
| Bergstrom, DE; Crow, FW; Gross, ML; McCloskey, JA; Tomer, KB | 1 |
| Glazer, RI; Knode, MC | 1 |
| Dirheimer, G | 1 |
| Heus, HA; Hinz, HJ; Van Kimmenade, JM; van Knippenberg, PH | 1 |
| Hudig, D; Redelman, D | 1 |
| Aksamit, RR; Backlund, PS | 1 |
| Hamersma, M; Van Buul, CP; Van Knippenberg, PH; Visser, W | 1 |
| Bowersox, JC; Sorgente, N | 1 |
| Porta, R; Schatz, RA; Sellinger, OZ; Wilens, TE | 1 |
| Rutledge, CO; Samet, MK | 1 |
| Barber, JR; Clarke, S | 1 |
| Cherayil, JD; Raviprakash, KS | 1 |
| Rao, SN; Sasisekharan, V | 1 |
| Gregor, P; Schatz, RA; Sellinger, OZ; Tatter, SB; Wilens, TE | 1 |
| Bartel, RL; Borchardt, RT | 1 |
| Poirier, LA; Shivapurkar, N; Wilson, MJ | 1 |
| Alix, JH | 1 |
| Bakker, H; Poldermans, B; Van Knippenberg, PH | 1 |
| McCammon, MT; Parks, LW | 1 |
| Heus, HA; Van Charldorp, R; Van Knippenberg, PH | 1 |
| De Bruin, SH; Heus, HA; Hilbers, CW; Joordens, J; Van Charldorp, R; Van Knippenberg, PH | 1 |
| Chiang, PK; Montgomery, JA; Shattil, SJ | 1 |
| Glazer, RI; Lloyd, LS | 1 |
| Schanche, JS; Schanche, T; Ueland, PM | 1 |
| Kredich, NM; Pike, MC; Snyderman, R | 1 |
| Schatz, RA; Sellinger, OZ; Wilens, TE | 2 |
| Cartenì-Farina, M; Della Ragione, F; Galletti, P; Manna, C; Oliva, A | 1 |
| Cartenì-Farina, M; Della Ragione, F; Galletti, P; Giordano, F; Manna, C; Oliva, A | 1 |
| Cohen, OJ; Glazer, RI; Hartman, KD | 1 |
| Garrett, C; Kredich, NM | 1 |
| Kan, LS; Ts'o, PO; Yano, J | 1 |
| Bynum, JW | 1 |
| Glazer, RI; Stern, HJ | 1 |
| Hoffman, JL | 2 |
| Bokar, JA; Reddy, R; Rottman, F; Shimba, S | 1 |
| Connolly, BA; Szczelkun, MD | 1 |
| Connolly, BA; Jones, H; Szczelkun, MD | 1 |
| Andrei, G; Balzarini, J; Chen, X; De Clercq, E; Ikeda, S; Rao, J; Schneller, SW; Siddiqi, SM; Snoeck, R | 1 |
| De Santo, NG; Galletti, P; Ingrosso, D; Perna, AF; Zappia, V | 1 |
| Bokar, JA; Ludwiczak, R; Narayan, P; Rottman, FM; Shambaugh, ME | 1 |
| Camborde, F; Caussade, F; Cloarec, A; Güngör, T; Hertz, F; Malabre, P; Meignen, J; Teulon, JM; Virone-Oddos, A | 1 |
| Bergmann, S; Lehmann, V; Ratter, F; Schiemann, S; Schulze-Osthoff, K; Shatrov, V | 1 |
| Delcour, J; Desgrès, J; Glasser, AL; Lafontaine, D; Vandenhaute, J | 1 |
| Liljas, A; Svensson, LA; Vidgren, J | 1 |
| Arnsmeier, SL; Clark, SH; Mirkin, BL; Paller, AS | 1 |
| Bergman, P; Lory, S; Strom, MS | 1 |
| Chance, ML; Goad, LJ; Haughan, PA | 1 |
| Bu, G; Oxenrider, KA; Sitz, TO | 1 |
| Altschuld, RA; Hohl, CM; Hu, B | 1 |
| Hemavathy, KC; Nagaraja, V | 1 |
| Alleman, MM; Bacchi, CJ; Dwyer, DM; Gottlieb, M; Mann, VH; Yarlett, N | 1 |
| Tsiftsoglou, AS; Vizirianakis, IS | 2 |
| Cronstein, BN; Merrill, JT | 1 |
| Aarbakke, J; Endresen, PC; Kildalsen, H; Loennechen, T | 1 |
| Clark, SH; Hamre, MR; Mirkin, BL | 1 |
| Hasegawa, T; Mihara, M; Nakamuro, K; Sayato, Y | 1 |
| Allen, PT; Poirier, LA | 1 |
| Béliveau, R; Boivin, D; Lin, W | 1 |
| Hughes, JM; Maden, BE | 1 |
| Aletta, JM; Cimato, TR; Ettinger, MJ; Zhou, X | 1 |
| Bontemps, F; Van Den Berghe, G | 1 |
| Cronstein, BN | 1 |
| Ai, LS; Hsieh, M; Li, C; Li, SY; Li, YC; Lin, CH | 1 |
| Moore, PB; Rife, JP | 1 |
| Podhajska, AJ; Tucholski, J; Zmijewski, JW | 1 |
| Branlant, C; Hartmuth, K; Huber, J; Lührmann, R; Raker, VA | 1 |
| Douthwaite, S; Vester, B; Villsen, ID | 1 |
| Seitz, M | 1 |
| Douthwaite, S; Puglisi, JD; Recht, MI | 1 |
| Beal, PA; Easterwood, LM; Kamilar, GM; Yi-Brunozzi, HY | 1 |
| Douthwaite, S; Nielsen, AK; Vester, B | 1 |
| Ashizawa, K; Miyamoto, M; Tsuzuki, Y | 1 |
| Hamilton, BJ; Herschman, HR; High, FA; Nichols, RC; Rigby, WF; Tang, J; Wang, XW | 1 |
| Gross, HJ; Jank, P | 1 |
| Muth, GW; Ortoleva-Donnelly, L; Strobel, SA | 1 |
| Hsieh, M; Li, C; Li, SY; Li, YC; Lin, CH; Pearson, DL; Pollard, KM | 1 |
| Ashihara, H; Crozier, A; Kato, A; Koshiishi, C; Yama, S | 1 |
| Bambara, RA; Demeter, LM; Klimatcheva, E; Planelles, V; Renda, MJ; Rosenblatt, JD | 1 |
| Ebert, MO; Grubmayr, K; Höbartner, C; Jaun, B; Micura, R; Pils, W | 1 |
| Clarke, S; Griffith, SC; Thapar, N; Yeates, TO | 1 |
| Allen, MS; Martin-McCaffrey, L; Moffatt, BA; Pereira, LA; Snider, JD; Stevens, YY; Summers, PS; Todorova, MI; Wagner, C; Weretilnyk, EA | 1 |
| Ashihara, H; Crozier, A; Kato, M; Ye, CX; Zheng, XQ | 1 |
| Hofmann, PA; Liu, Q | 1 |
| Hebert, MD; Matera, AG; Ospina, JK; Shpargel, KB; Tucker, KE | 1 |
| DeGregorio, SJ; Steitz, JA; Strobel, SA; Szewczak, LB | 1 |
| Gastaldo, L; Marinelli, F | 1 |
| Belyanskaya, LL; Delattre, O; Gehring, H | 1 |
| Hood, RD; Lammon, CA; Le, XC | 1 |
| Garber, M; Hai, CM; Harrington, EO; Hirase, T; Lu, Q; Newton, J; Rounds, S | 1 |
| Hermes, M; Kloor, D; Mattar, J; Osswald, H | 1 |
| Bedford, MT; Cheng, D; Lee, J | 1 |
| Barve, S; Chen, T; Kang, YJ; McClain, CJ; Song, Z; Uriarte, S; Wang, L; Zhou, Z | 1 |
| Cutler, P; Gaylor, DW; James, SJ; Janak, L; Jernigan, S; Melnyk, S; Neubrander, JA | 1 |
| Chen, DH; Hsieh, M; Hung, CJ; Li, C; Wu, KT | 1 |
| Cacciapuoti, G; Concilio, L; Forte, S; Graziano, G; Merlino, A; Moretti, MA; Porcelli, M | 1 |
| Fabrega, C; Hausmann, S; Lima, CD; Schneller, SW; Shuman, S; Zheng, S | 1 |
| Gabruzsk, J; Holmes, WM; Watts, JM | 1 |
| Basu, A; Bhattacharyya, S; Chaudhuri, P; Ghosh, AK; Sengupta, S | 1 |
| Rajski, SR; Weller, RL | 1 |
| Charlton, CG; Chen, H; Lee, ES; Soliman, KF | 1 |
| Afman, LA; Blom, HJ; Brouns, MR; Drittij, MJ; van Straaten, HW | 1 |
| Schulze-Osthoff, K; Schwerk, C | 1 |
| Petersen, SG; Rajski, SR | 1 |
| Barak, AJ; Beckenhauer, HC; Kharbanda, KK; Mailliard, ME; Rogers, DD; Siford, GL; Sorrell, MF; Tuma, DJ | 1 |
| Biron, VL; Heit, R; Hendzel, MJ; McManus, KJ; Underhill, DA | 1 |
| Christen, V; Duong, FH; Filipowicz, M; Heim, MH | 1 |
| Ghosh, A; Hausmann, S; Lima, CD; Liu, Q; Schwer, B; Shuman, S; Zheng, S | 1 |
| Hermes, M; Kloor, D; Osswald, H | 2 |
| Apolloni, A; Bodetti, TJ; Harrich, D; Hitchen, EM; Piller, SC; Warrilow, D; Willemsen, NM | 1 |
| Chorba, JS; Li, J; Whelan, SP | 1 |
| Couture, JF; Dietzel, K; Dirk, LM; Flynn, EM; Houtz, RL; Trievel, RC | 1 |
| Chen, W; Jiang, X; Karuturi, RK; Lee, PL; Liu, ET; Tan, J; Tan, PB; Yang, X; Yu, Q; Zhuang, L | 1 |
| Gong, X; Lalonde, MS; Li, Z; Malhotra, A; Wu, S; Zhang, J; Zuo, Y | 1 |
| Chatgilialoglu, C; D'Angelantonio, M; Gimisis, T; Guerra, M; Kaloudis, P; Mulazzani, QG | 1 |
| Rodríguez-López, JN; Sánchez-del-Campo, L | 1 |
| Lescar, J; Lim, SP; Vasudevan, SG; Wen, D; Yan, CK; Yap, TL | 1 |
| Enya, Y; Kitagawa, H; Masutomi, Y; Nagata, S; Ohgi, T; Oka, N; Takagaki, K; Wada, T; Yano, J | 1 |
| Galloway, SE; Wertz, GW | 1 |
| Heo, J; Heo, S; Hong, S; Kim, SS; Kwon, M; Lee, S; Lee, YD | 1 |
| Giessing, AM; Gondela, A; Hansen, LH; Jensen, SS; Kirpekar, F; Long, K; Rasmussen, A; Vester, B | 1 |
| Anilkumar, N; Cave, AC; Kentish, JC; Layland, J; Marshall, M; Shah, AM; Walker, SJ | 1 |
| Demina, I; Dontsova, OA; Golovin, AV; Golovina, AY; Govorun, VM; Serebryakova, MV; Sergiev, PV | 1 |
| Abe, M; Cortez, CC; Jones, PA; Kelly, TK; Liang, G; Marquez, VE; Miranda, TB; Yoo, CB | 1 |
| Bressan, GC; Gomes, MD; Kobarg, J; Kuniyoshi, TM; Manfiolli, AO; Moraes, EC; Passos, DO | 1 |
| Chan, GK; Heit, R; Hendzel, MJ; Rattner, JB | 1 |
| Hu, ML; Lin, HC; Liu, CL; Yang, CM | 1 |
| Hagiwara, H; Hoshino, T; Ishikawa, M; Murai, R; Suyama, K | 1 |
| Chan, E; Marquez, VE; Sun, F; Wu, Z; Yang, X; Yu, Q | 1 |
| Ge, J; Liu, H; Yu, YT | 1 |
| Chao, AT; Chung, KY; Dong, H; Lescar, J; Lim, SP; Shi, PY | 1 |
| Bodi, Z; Button, JD; Fray, RG; Grierson, D | 1 |
| Fu, Y; He, C; Pan, T; Pavon-Eternod, M; Saikia, M | 1 |
| Banerjee, S; Chaudhuri, P; Dutta, T; Ghosh, AK; Lahiri, S; Majhi, R; Sengupta, S | 1 |
| Hong, E; Kwon, D; Lee, E; Lim, Y | 1 |
| Choi, YL; Hasegawa, H; Hayashi, T; Imaizumi, Y; Kamihira, S; Mano, H; Marquez, VE; Miyazaki, Y; Moriwaki, Y; Osaka, A; Sasaki, D; Tsukasaki, K; Yamada, Y; Yanagihara, K | 1 |
| Beis, K; Cameron, AD; Choudhury, HG; Iwata, S | 1 |
| Ahlum, JH; Benner, JS; Booker, SJ; Grove, TL; Krebs, C; Landgraf, BJ; Radle, MI | 1 |
| Stubbe, J | 1 |
| Lin, H | 1 |
| Dai, Q; Fu, Y; He, C; Jia, G; Lindahl, T; Pan, T; Yang, Y; Yang, YG; Yi, C; Zhao, X; Zheng, G | 1 |
| Chinnaiyan, AM; He, S; Kato, K; Kuick, R; Liu, Y; Mani, RS; Marquez, VE; Mineishi, S; Mochizuki, K; Nieves, E; Varambally, S; Wang, J; Xie, F; Zhang, Y | 1 |
| Brzezinski, K; Dauter, Z; Jaskolski, M | 1 |
| Chang, DC; Chionh, YH; Dedon, PC; Dong, H; Hia, F; Hua, MH; Kukkaro, P; Lee, YH; Lim, SP; Lok, SM; Shi, PY | 1 |
| Amariglio, N; Cesarkas, K; Dominissini, D; Jacob-Hirsch, J; Kupiec, M; Moshitch-Moshkovitz, S; Osenberg, S; Rechavi, G; Salmon-Divon, M; Schwartz, S; Sorek, R; Ungar, L | 1 |
| Elemento, O; Jaffrey, SR; Mason, CE; Meyer, KD; Saletore, Y; Zumbo, P | 1 |
| Bay, BH; Cheng, LL; Chia, NY; Itahana, K; Itahana, Y; Lei, ZD; Pandey, A; Rozen, S; Tan, P; Tan, PH; Thike, AA; Voorhoeve, PM; Wu, Y; Yu, Q; Yu, Y; Zhang, SL | 1 |
| Akira, S; Bathke, B; Bauer, S; Buer, J; Dreher, S; Ferstl, R; Hochrein, H; Kaufmann, A; Kawai, T; Kirschning, CJ; Koedel, U; Krüger, A; Lauterbach, H; Nees, G; Oldenburg, M; Sigmund, A; Suter, M; Wagner, H | 1 |
| Cakir, Y; Yildiz, D | 1 |
| Dosaka-Akita, H; Kikuchi, E; Kikuchi, J; Kinoshita, I; Marquez, VE; Nishimura, M; Oizumi, S; Sakakibara-Konishi, J; Shimizu, Y; Takashina, T | 1 |
| Olsen, M; Powers, R; Rowles, J; Wong, M | 1 |
| Fu, Y; He, C | 1 |
| Endo-Munoz, L; Gannon, OM; Hazar-Rethinam, M; Merida de Long, L; Saunders, NA | 1 |
| Fu, Y; He, C; Jia, G | 1 |
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| Jiang, K; Shen, Z; Wang, B; Wang, L; Wang, Q; Wang, S; Yang, C; Ye, Y; Zhang, M; Zhang, Z; Zhao, L | 1 |
| Liu, H; Ma, J; Mao, Y; Zhang, L | 1 |
| Aggad, WS; Almohaimeed, HM; Alshanwani, AR; Assiri, R; Hengwei, Y; Raza, SHA; Wenzhen, Z; Xinran, Y; Zan, L | 1 |
| Huang, H; Huang, T; Jiang, J; Li, Y; Wu, S; Zhou, Y | 1 |
| Gao, C; Guo, R; Wang, X; Wu, Y; Yan, J; Zhao, L | 1 |
| Abuduwaili, N; Huang, G; Huang, X; Tao, M; Wang, X | 1 |
| Abou-Aisha, K; Elsabbagh, RA; Gad, MZ; Rady, M; Watzl, C | 1 |
| Chen, JJ; Feng, YQ; He, J; Qi, CB; Tang, F; Wang, J; You, XJ; Yuan, BF; Zhang, S | 1 |
| Bonini, NM; Liu, KF; Perlegos, AE; Shen, H; Shields, EJ | 1 |
| Cheng, X; Wang, JL; Zha, LF | 1 |
| Chen, M; Ge, R; He, C; Hu, L; Liu, S; Meng, H; Peng, Y | 1 |
| Fukami, T; Isono, M; Nakajima, M; Nakano, M | 1 |
| Guo, MY; He, JQ; Qiu, FS; Yu, CH; Zhong, YS | 1 |
| Cheng, W; Li, M; Peng, X; Yu, S; Zhang, L; Zhang, W; Zhou, C | 1 |
| Chen, Z; Guo, HH; Jin, DX; Li, YM; Liang, JH; Sun, GD; Wang, DP; Xie, WX; Zhong, C; Zhong, LP; Zhuang, WD | 1 |
| Feng, Y; Gu, J; Gu, X; Su, T; Wang, Y | 1 |
| Ji, FH; Lowe, S; Qiu, XG; Sun, C; Yang, Z | 1 |
| Bhati, KK; Blaakmeer, A; Dolde, U; Edwards, A; Jia, G; Kruusvee, V; Petri, L; Rodrigues, V; Song, P; Straub, D; Sun, B; Wenkel, S; Yang, J | 1 |
| Li, F; Xu, YL; Yang, FF | 1 |
| Abudurufu, M; Cai, HY; Chen, TF; Ke, ZF; Lei, YY; Luo, HH; Shan, SC; Yang, HS; Zhu, Y; Zou, JY | 1 |
| Heissmeyer, V; Ito-Kureha, T | 1 |
| Hu, B; Li, X; Ni, X; Wang, L | 1 |
| Li, L; Xu, L; Yan, C; Zhou, L | 1 |
| Chen, J; Feng, Q; Hu, Y; Liu, M; Peng, H | 1 |
| Albers, M; Muthmann, N; Rentmeister, A | 1 |
| Chen, X; Ji, JD; Liu, QH; Sun, RX; Wang, JN; Wang, Y; Zhang, YR; Zhu, HJ | 1 |
| Feng, XM; Ji, XL; Liu, FY; Su, XL | 1 |
| Liu, DW; Liu, XX | 1 |
| Bassik, MC; Cai, T; Cruz, PHC; Han, K; Hatada, I; Hia, F; Horii, T; Kajiya, A; Kawahara, Y; Kobayashi, R; Morgens, DW; Suzuki, Y; Takeuchi, O; Tsuruyama, T; Vandenbon, A; Yasukura, S; Yoshinaga, M | 1 |
| Jiang, B; Liang, P; Ran, Y; Yan, Z | 1 |
| Chen, Q; Guo, J; Lv, N; Shen, S; Tong, J | 1 |
| Hu, Z; Huang, C; Liu, J; Sun, G; Wan, L; Wang, K; Zhu, L; Zhu, Z | 1 |
| Guo, T; Li, Y; Liu, R; Liu, Y; Yi, J; Zhou, Y | 1 |
| Klinge, CM; Petri, BJ | 1 |
| Gao, Y; Hao, M; Kan, S; Liu, H; Liu, W; Wang, D; Wang, Y; Xue, T; Yang, Z | 1 |
| Hong, J; Lee, JH; Xu, K | 1 |
| Calis, JJA; van Loosdregt, J | 1 |
| Gatsiou, A; Stellos, K | 1 |
| Darsinou, M; Martinez De La Cruz, B; Riccio, A | 1 |
| Ai, S; Cao, L; Cui, X; Gao, L; Jiang, T; Wang, S; Yin, H; Zheng, Y; Zhou, Y | 1 |
| Guo, Y; He, S; Shi, Z; Shu, Y; Zheng, Y | 1 |
| Guo, Z; Wang, X; Yan, F | 1 |
| Cao, X; Deng, T; Fan, D; Geng, Q; Gu, X; Wang, Z; Xiao, C; Zhang, M; Zhang, Q | 1 |
| Chen, M; Ge, R; He, C; Liu, S; Tang, W; Wu, Y; Xiao, YL | 1 |
| Gu, S; He, Z; Liu, X; Mei, Z; Mou, Y; Zhang, N | 1 |
| Shen, L; Teo, ZWN; Wong, CE; Xu, T; Yan, A; Yu, H; Zhang, S; Zhang, Y | 1 |
| Cai, Y; Chen, T; Deng, L; Fu, S; Li, C; Wang, M; Xie, K | 1 |
| Jin, H; Lu, S; Wei, X; Yu, Y; Zhao, M; Zhou, T; Zhu, H | 1 |
| Sendinc, E; Shi, Y | 1 |
| Cesaro, B; Fatica, A; Tarullo, M | 1 |
| Chen, J; Chen, L; Chen, X; Cui, Y; Fang, F; Hu, L; Li, L; Li, Z; Luo, Y; Zhang, Z | 1 |
| Li, X; Wang, X; Wu, J | 1 |
| Chen, J; Chen, R; Garza, LA; Hu, Z; Kang, S; Liao, W; Miao, Y; Sweren, E; Wang, G; Wang, J; Zeng, D | 1 |
| Cao, X; Deng, T; Fan, D; Geng, Q; Jia, L; Jiao, Y; Liu, H; Wang, Q; Wang, X; Xiao, C; Zhang, M; Zhao, L; Zhou, J | 1 |
| Ding, L; Liu, Y; Zhu, J | 1 |
| Guo, Z; Huang, Y; Lai, S; Li, T; Lin, C; Wang, Y; Weng, S; Zhang, X | 1 |
| Duan, D; Feng, H; Guo, Z; Tang, W; Wang, R | 1 |
| Chen, LZ; Hong, XQ; Liu, P; Liu, ZY; Zheng, PF; Zheng, ZF | 1 |
| Han, Y; Li, B; Li, H; Meng, W | 1 |
| Cao, S; Liu, C; Wang, X; Yang, S | 1 |
| Chen, G; Chen, L; Chen, X; He, Y; Liu, S; Ni, Z; Qi, S; Xie, T; Zhang, H; Zhao, S; Zhou, Y; Zhu, J | 1 |
| Abdel-Wahab, O; Zhang, P | 1 |
| Chen, H; Chen, Y; Li, X; Nie, J; Zhang, M | 1 |
| Abis, G; Cai, Y; Chaves-Arquero, B; Esteban-Serna, S; Figueiredo, AM; Gallagher, C; Klein, P; Martin, SR; Nicastro, G; Patani, R; Ramos, A; Taylor, IA | 1 |
| Bai, J; Bao, J; Chen, J; Hu, C; Kan, J; Lu, F; Tang, Q; Tian, Y; Wang, B; Yan, L; Ye, M; Yu, P; Zhong, Y | 1 |
| Dus, M; Wilinski, D | 1 |
| Li, L; Li, X; Wu, F; Yin, R; Yuan, M; Zhang, Y; Zhao, X | 1 |
| Hong, LL; Li, P; Ling, ZQ; Liu, Z; Qi, YN | 1 |
| Abdel-Maksoud, MA; Almutairi, SM; Alshalani, AJ; Alturaiki, W; Aufy, M; Hameed, Y; Li, C; Li, H; Mahmoud, AM; Mubarak, A; Xu, W | 1 |
| An, X; Duan, Y; Ji, H; Jiang, L; Kang, X; Lian, F; Sun, W; Sun, Y; Yang, C; Zhang, Y; Zhang, Z; Zhao, X | 1 |
| Conrad, NK; Flaherty, JN; Hunter, OV; Ruiz, JC | 1 |
| Chen, H; Chen, Z; Li, H; Liu, X; Ma, S; Pan, Y; Yu, M; Zeng, W | 1 |
| Hua, R; Li, Y; Zhou, L; Zhou, W | 1 |
| Jin, L; Li, W; Li, Y; Shen, X; Wang, Y; Zhou, X | 1 |
| Li, XJ; Lin, L; Xie, J; Xie, L; Xu, Y; Zhang, X | 1 |
| Luan, Z; Wang, Y | 1 |
| Wang, XJ; Zhang, Z | 1 |
| Benevolenskaya, EV; Glynn, S; Hoffman, B; Islam, ABMMK; Kuschman, HP; Menhart, M; Palczewski, MB; Thomas, DD; Wang, X | 1 |
| Luo, L; Yang, Y; Zhou, Z | 1 |
| Cui, B; Mao, Z; Wang, B; Zhang, T | 1 |
| Arzumanian, VA; Khmeleva, SA; Kurbatov, IY; Kurbatov, LK; Poverennaya, EV; Ptitsyn, KG; Radko, SP | 1 |
190 review(s) available for isomethyleugenol and adenosine
| Article | Year |
|---|---|
[The 5'-terminal cap structure of eukaryotic messenger RNAs (author's transl)].
Topics: Adenosine; Base Sequence; Insect Viruses; Methylation; Protein Biosynthesis; Reoviridae; RNA, Messenger; RNA, Viral; Transcription, Genetic | 1977 |
Methylation of mRNA.
Topics: Adenosine; Animals; Avian Sarcoma Viruses; Base Sequence; Cattle; Methylation; Methyltransferases; Molecular Sequence Data; Prolactin; RNA, Messenger; RNA, Viral; Substrate Specificity | 1992 |
Purine nucleotide imbalance in immunodeficiency disorders.
Topics: 5'-Nucleotidase; Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Autoimmune Diseases; B-Lymphocytes; Child; Child, Preschool; Cyclic AMP; Deoxyadenosines; Erythrocytes; Humans; Immunologic Deficiency Syndromes; Lymphocytes; Methylation; Nucleotidases; Phosphoribosyl Pyrophosphate; Purine Nucleotides; Purine-Nucleoside Phosphorylase; Ribonucleotide Reductases; T-Lymphocytes | 1985 |
Formation, functions and regulatory importance of S-adenosyl-L-methionine.
Topics: Adenosine; Adenosine Triphosphate; Alkanes; Alkenes; Alkynes; Amino Acids; Animals; Antineoplastic Agents; Binding Sites; Carbon Isotopes; Carboxylic Acids; Cyclopentanes; Escherichia coli; Homocysteine; Homoserine; Kinetics; Liver; Methionine; Methylation; Mice; Neoplasms, Experimental; Rats; Spleen; Transferases; Tritium; Yeasts | 1970 |
Altered methionine metabolism, DNA methylation and oncogene expression in carcinogenesis. A review and synthesis.
Topics: Adenosine; Animals; Azacitidine; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Choline; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA, Viral; Ethionine; Gene Expression Regulation; Homocysteine; Humans; Methionine; Methylation; Methyltransferases; Neoplasms; Oncogenes; Oncogenic Viruses; S-Adenosylhomocysteine; S-Adenosylmethionine; Simian virus 40 | 1984 |
The possible role of protein-carboxyl methylation in sperm motility and capacitation.
Topics: Adenine; Adenosine; Animals; Dyneins; Homocysteine; Humans; Infertility, Male; Male; Methylation; Mitochondria; Protein Methyltransferases; Protein O-Methyltransferase; Sperm Capacitation; Sperm Motility; Spermatogenesis; Spermatozoa; Testis | 1982 |
Chemical nature, properties, location, and physiological and pathological variations of modified nucleosides in tRNAs.
Topics: Adenosine; Animals; Anticodon; Base Sequence; Codon; Humans; Methylation; Mitochondria; Nucleic Acid Conformation; Nucleosides; RNA, Transfer; Saccharomyces cerevisiae; Species Specificity; Uracil | 1983 |
Chemotaxis and methylation in a macrophage cell line.
Topics: Adenine; Adenosine; Animals; Blood Proteins; Cell Line; Chemotaxis, Leukocyte; Guinea Pigs; Humans; Macrophages; Methylation; Mice; Phosphatidylethanolamines; Rabbits; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1983 |
Molecular aspects of the in vivo and in vitro effects of ethionine, an analog of methionine.
Topics: Adenosine; Animals; Bacteria; Cell Differentiation; Cell Division; DNA Replication; Ethionine; Humans; Liver; Methionine; Methylation; Protein Biosynthesis; Protein Processing, Post-Translational; Ribosomes; RNA Processing, Post-Transcriptional; RNA, Ribosomal; Yeasts | 1982 |
N6-adenosine methylation in mRNA: substrate specificity and enzyme complexity.
Topics: Adenosine; Animals; Base Sequence; Humans; Methylation; Methyltransferases; Molecular Sequence Data; RNA, Messenger; Substrate Specificity | 1994 |
Bioactivation by S-adenosylation, S-methylation, or N-methylation.
Topics: Adenosine; Animals; Biotransformation; Humans; Methylation; Xenobiotics | 1994 |
Eukaryotic ribosomal RNA: the recent excitement in the nucleotide modification problem.
Topics: Adenosine; Animals; Cell Nucleolus; Eukaryotic Cells; Humans; Methylation; Pseudouridine; RNA, Ribosomal | 1997 |
The mechanism of action of methotrexate.
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Methotrexate; Methylation | 1997 |
Molecular and cellular effects of methotrexate.
Topics: Adenosine; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cytokines; Humans; Methotrexate; Methylation | 1999 |
S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used?
Topics: Adenosine; Alkylation; Cyclopropanes; Cytosine; DNA; Histidine; Methylation; Methyltransferases; Nucleosides; RNA; RNA, Ribosomal, 23S; S-Adenosylmethionine | 2011 |
Nucleic acid modifications with epigenetic significance.
Topics: 5-Methylcytosine; Adenosine; Animals; Cytosine; DNA; Epigenesis, Genetic; Humans; Methylation; RNA | 2012 |
Reversible RNA adenosine methylation in biological regulation.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Humans; Methylation; Models, Genetic; Oxidoreductases, N-Demethylating; Proteins; RNA; RNA Splicing; RNA Stability; RNA, Messenger | 2013 |
N6-methyl-adenosine modification in messenger and long non-coding RNA.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Cell Nucleus; Gene Expression Profiling; Humans; Methylation; Protein Biosynthesis; Proteins; RNA Processing, Post-Transcriptional; RNA Splicing; RNA Transport; RNA, Long Noncoding; RNA, Messenger | 2013 |
N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function.
Topics: 3' Untranslated Regions; Adenosine; Animals; Epigenesis, Genetic; Humans; Methylation; Methyltransferases; Oxidoreductases, N-Demethylating; RNA; RNA Splicing; RNA Stability; RNA, Messenger; Transcription, Genetic | 2013 |
Gene expression regulation mediated through reversible m⁶A RNA methylation.
Topics: Adenosine; Animals; Epigenesis, Genetic; Eukaryotic Cells; Gene Expression Regulation; Humans; Methylation; Methyltransferases; RNA, Messenger | 2014 |
The dynamic epitranscriptome: N6-methyladenosine and gene expression control.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Dioxygenases; Epigenesis, Genetic; Gene Expression; Humans; Membrane Proteins; Methylation; Methyltransferases; Proteins; RNA Stability; RNA, Messenger; Transcriptome | 2014 |
Role of RNA methyltransferases in tissue renewal and pathology.
Topics: Adenosine; Animals; Cytidine; Humans; Methylation; Methyltransferases; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome | 2014 |
Fate by RNA methylation: m6A steers stem cell pluripotency.
Topics: Adenosine; Animals; Cell Differentiation; Embryonic Stem Cells; Methylation; Mice; Phenotype; Pluripotent Stem Cells; RNA, Messenger | 2015 |
RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.
Topics: Adenosine; Animals; Cellular Reprogramming; Embryonic Development; Eukaryota; Evolution, Molecular; Gene Expression Regulation; Humans; Methylation; Methyltransferases; RNA Processing, Post-Transcriptional; RNA, Messenger | 2015 |
EZH2 in normal hematopoiesis and hematological malignancies.
Topics: Adenosine; B-Lymphocytes; Cell Differentiation; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Ethylenediamines; Gene Expression Regulation; Hematologic Neoplasms; Hematopoiesis; Hematopoietic Stem Cells; Histones; Humans; Indoles; Methylation; Polycomb Repressive Complex 2; Precision Medicine; Pyrazoles; Pyridones | 2016 |
N6-methyladenosine modification in mRNA: machinery, function and implications for health and diseases.
Topics: Adenosine; Cell Differentiation; Eukaryotic Cells; Humans; Methylation; Methyltransferases; Neoplasms; Neurodegenerative Diseases; Oxidoreductases, N-Demethylating; RNA Splicing; RNA, Long Noncoding; RNA, Messenger; Signal Transduction; Transcription, Genetic | 2016 |
N6-Methylated Adenosine in RNA: From Bacteria to Humans.
Topics: Adenosine; Escherichia coli; Humans; Methylation; Methyltransferases; RNA | 2016 |
Cracking the epitranscriptome.
Topics: Adenosine; Animals; Epigenesis, Genetic; Humans; Methylation; Mice; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome | 2016 |
N (6)-Methyladenosine (m(6)A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification.
Topics: Adenosine; Animals; Epigenesis, Genetic; Eukaryotic Cells; Gene Expression Regulation; Humans; Methylation; Methyltransferases; RNA, Messenger | 2016 |
Recent advances in dynamic m6A RNA modification.
Topics: Adenosine; Animals; Humans; Immunity; Methylation; RNA; RNA, Long Noncoding; RNA, Messenger | 2016 |
Messenger RNA modifications: Form, distribution, and function.
Topics: 5-Methylcytosine; Adenosine; Animals; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Humans; Methylation; Methyltransferases; Pseudouridine; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome | 2016 |
m(6)A: Signaling for mRNA splicing.
Topics: Adenosine; Alternative Splicing; Animals; Humans; Methylation; Protein Binding; RNA Splicing; RNA Splicing Factors; RNA, Messenger; Serine-Arginine Splicing Factors; Signal Transduction | 2016 |
Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cell Adhesion Molecules; Cytokines; Eicosanoids; Folic Acid Antagonists; Humans; Metalloproteases; Methotrexate; Methylation; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Reactive Oxygen Species; Signal Transduction; Treatment Outcome | 2016 |
Post-transcriptional gene regulation by mRNA modifications.
Topics: 5-Methylcytosine; Adenosine; Animals; Cell Cycle; Cell Differentiation; Circadian Rhythm; Gene Expression Regulation; Humans; Methylation; Nucleic Acid Conformation; Protein Biosynthesis; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger | 2017 |
Human m
Topics: Adenosine; Catalysis; Cell Cycle Proteins; Epigenesis, Genetic; Humans; Methylation; Methyltransferases; Nuclear Proteins; RNA; RNA Splicing Factors; Structure-Activity Relationship | 2017 |
m1A Post-Transcriptional Modification in tRNAs.
Topics: Adenosine; Animals; Enzymes; Humans; Methylation; Models, Molecular; RNA Processing, Post-Transcriptional; RNA, Transfer | 2017 |
Viral Epitranscriptomics.
Topics: Adenosine; DNA Viruses; HIV-1; Humans; Methylation; Methyltransferases; RNA Processing, Post-Transcriptional; RNA Viruses; RNA, Messenger; RNA, Viral | 2017 |
Regulatory Role of N
Topics: Adenosine; Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Humans; Methylation; Neoplasms; Obesity; RNA Processing, Post-Transcriptional; RNA, Neoplasm | 2017 |
Readers, writers and erasers of N
Topics: Adenosine; Methylation; Methyltransferases; Models, Molecular; Molecular Conformation; Multiprotein Complexes; Protein Binding; RNA; Structure-Activity Relationship | 2017 |
Settling the m
Topics: Adenosine; Animals; Exons; HeLa Cells; Humans; Methylation; Methyltransferases; RNA Splicing; RNA, Messenger | 2017 |
Roles of RNA methylation by means of N
Topics: Adenosine; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional | 2017 |
The emerging role of mRNA methylation in normal and pathological behavior.
Topics: Adenosine; Behavior; Brain; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation; Humans; Methylation; RNA, Messenger; Transcriptome | 2018 |
The Role of Dynamic m
Topics: Adenosine; Circadian Clocks; DNA Damage; DNA Repair; Humans; Methylation; Neoplasms; RNA; Stem Cells; Ultraviolet Rays | 2019 |
Mechanism of N
Topics: Adenosine; Animals; Histone Demethylases; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Editing | 2018 |
Adenosine methylation as a molecular imprint defining the fate of RNA.
Topics: Adenosine; Cell Nucleus; Humans; Methylation; Protein Biosynthesis; RNA Folding; RNA Stability; RNA, Messenger | 2018 |
m
Topics: Adenosine; Humans; Methylation; Nervous System Diseases; Neurogenesis | 2019 |
N
Topics: Adenosine; Animals; Epigenesis, Genetic; Humans; Methylation; RNA, Long Noncoding; RNA, Messenger; RNA, Mitochondrial; RNA, Nuclear; Transcriptome | 2018 |
Methylation of RNA N
Topics: Adenosine; Animals; Carcinogenesis; Cytokines; Humans; Methylation; Neoplasms; RNA | 2019 |
The Epitranscriptome in Translation Regulation.
Topics: Adenosine; Animals; Cytidine; Epigenomics; Gene Expression Regulation; Homeostasis; Humans; Methylation; Peptide Chain Elongation, Translational; Peptide Chain Initiation, Translational; Protein Biosynthesis; Pseudouridine; RNA, Messenger; RNA, Transfer; Transcription, Genetic; Transcriptome | 2019 |
The dual role of N6-methyladenosine modification of RNAs is involved in human cancers.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Carcinogenesis; Disease Progression; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genetic Therapy; Humans; Methylation; Methyltransferases; Molecular Targeted Therapy; Neoplasms; RNA Editing; RNA, Neoplasm | 2018 |
N6-Methyladenosine Role in Acute Myeloid Leukaemia.
Topics: Adenosine; DNA; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid, Acute; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger | 2018 |
Aberrant Regulation of mRNA m⁶A Modification in Cancer Development.
Topics: Adenosine; Animals; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Neoplasms; RNA, Messenger | 2018 |
Chemical Modifications in the Life of an mRNA Transcript.
Topics: Adenosine; Gene Expression Regulation; Humans; Methylation; Protein Biosynthesis; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome | 2018 |
Dynamic and reversible RNA N
Topics: Adenosine; Animals; Carrier Proteins; Histone Demethylases; Humans; Methylation; Methyltransferases; RNA | 2019 |
Mapping N
Topics: Adenosine; Animals; Antibodies; Gene Expression Profiling; Humans; Immunoprecipitation; Methylation; RNA, Messenger; Sequence Analysis, RNA; Transcriptome | 2019 |
RNA modifications in structure prediction - Status quo and future challenges.
Topics: Adenosine; Animals; Base Pairing; Base Sequence; Humans; Inosine; Methylation; MicroRNAs; Nucleic Acid Conformation; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Ribosomal; RNA, Small Nuclear; RNA, Transfer; Sequence Analysis, RNA; Transcriptome | 2019 |
A dynamic reversible RNA N
Topics: Adenosine; Epigenesis, Genetic; Humans; Lipid Metabolism; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger | 2019 |
The role of m6A RNA methylation in cancer.
Topics: Adenosine; Animals; Humans; Methylation; Neoplasms; RNA | 2019 |
Functions of RNA N6-methyladenosine modification in cancer progression.
Topics: Adenosine; Animals; Disease Progression; Humans; Methylation; Neoplasms; RNA | 2019 |
Importance of m N
Topics: Adenosine; Animals; DNA Damage; Humans; Methylation; Neoplasms; RNA, Neoplasm | 2019 |
The Critical Role of RNA m
Topics: Adenosine; Demethylation; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA-Binding Proteins | 2019 |
Functions of RNA N6-methyladenosine modification in cancer progression.
Topics: Adenosine; Disease Progression; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Processing, Post-Transcriptional | 2019 |
Detection of N6‑methyladenosine modification residues (Review).
Topics: Adenosine; Animals; Biosensing Techniques; Blotting, Northern; Chromatography, High Pressure Liquid; Electrochemical Techniques; Humans; Immunoblotting; Immunoprecipitation; Methylation; Neoplasms; RNA; Sequence Analysis, RNA | 2019 |
N6-methyladenosine regulatory machinery in plants: composition, function and evolution.
Topics: Adenosine; Evolution, Molecular; Methylation; Plants; RNA, Plant | 2019 |
Role of identified RNA N6-methyladenosine methylation in liver.
Topics: Adenosine; Eukaryota; Liver; Liver Diseases; Methylation; MicroRNAs; RNA Processing, Post-Transcriptional; RNA, Long Noncoding; RNA, Messenger; Viruses | 2019 |
A Review in Research Progress Concerning m6A Methylation and Immunoregulation.
Topics: Active Transport, Cell Nucleus; Adenosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA Splicing; RNA, Messenger | 2019 |
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers.
Topics: Adenosine; Eukaryotic Cells; Gene Expression Regulation; Methylation; Organ Specificity; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome | 2019 |
Small changes, big implications: The impact of m
Topics: Adenosine; Cell Self Renewal; Gene Expression Regulation, Developmental; Humans; Methylation; Pluripotent Stem Cells; RNA Processing, Post-Transcriptional | 2019 |
Reading, writing and erasing mRNA methylation.
Topics: Adenosine; Animals; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Neoplasm | 2019 |
RNA modifications and the link to human disease.
Topics: 5-Methylcytosine; Adenosine; Animals; Guanosine; Humans; Methylation; Nucleic Acid Conformation; Pseudouridine; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Ribosomal; RNA, Transfer; Uridine | 2019 |
The interplay between m6A RNA methylation and noncoding RNA in cancer.
Topics: Adenosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Neoplasm; RNA, Untranslated | 2019 |
Functions of N6-methyladenosine and its role in cancer.
Topics: Adenosine; Animals; Biomarkers; Disease Susceptibility; Gene Expression Regulation, Neoplastic; Humans; Methylation; Molecular Targeted Therapy; Neoplasms; Protein Binding; RNA, Messenger; Signal Transduction | 2019 |
N
Topics: Adenosine; Animals; Biomarkers; Disease Susceptibility; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Methylation; RNA | 2019 |
The Biogenesis and Precise Control of RNA m
Topics: Adenosine; Animals; Cell Differentiation; Eukaryotic Cells; Gene Expression Regulation; Humans; Methylation; Protein Processing, Post-Translational; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger | 2020 |
New sights in cancer: Component and function of N6-methyladenosine modification.
Topics: Adenosine; Animals; Epigenesis, Genetic; Humans; Methylation; Neoplasms; RNA; RNA, Messenger | 2020 |
Dynamic N6-methyladenosine RNA methylation in brain and diseases.
Topics: Adenosine; Brain; Histone Code; Humans; Mental Disorders; Methylation; Neurodegenerative Diseases; Neurogenesis; RNA, Messenger | 2020 |
Association of N6-methyladenosine with viruses and virally induced diseases.
Topics: Adenosine; Humans; Methylation; Methyltransferases; RNA Folding; RNA Stability; RNA-Binding Proteins; RNA, Viral; Virus Diseases; Viruses | 2020 |
Insights into the Regulatory Role of m
Topics: Adenosine; Brain Neoplasms; Cytosine; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; RNA, Ribosomal, 28S | 2020 |
Insights into the N
Topics: Adenosine; Animals; Gene Expression; Humans; Methylation; Plants; RNA; Yeasts | 2020 |
Research Progress of N6-Methyladenosine in the Cardiovascular System.
Topics: Adenosine; Cardiovascular Diseases; Cardiovascular System; Epigenesis, Genetic; Gene Expression; Humans; Lipid Metabolism; Lipids; Methylation; Methyltransferases | 2020 |
Diverse molecular functions of m
Topics: Adenosine; Alternative Splicing; Animals; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Nucleic Acid Conformation; Organ Specificity; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Structure-Activity Relationship | 2020 |
Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer.
Topics: Adenosine; Cell Physiological Phenomena; Cell Transformation, Neoplastic; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; Glycolipids; Humans; Methylation; Methyltransferases; Models, Biological; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplastic Stem Cells; Neovascularization, Pathologic; Protein Biosynthesis; Radiation Tolerance; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Neoplasm | 2020 |
Epigenetic role of N6-methyladenosine (m6A) RNA methylation in the cardiovascular system.
Topics: Adenosine; Animals; Cardiovascular Diseases; Circadian Rhythm; Epigenesis, Genetic; Humans; Methylation; RNA | 2020 |
N
Topics: Adenosine; Animals; Brain; Carrier Proteins; Eukaryota; Humans; Methylation; Methyltransferases; RNA | 2020 |
EZH2: a novel target for cancer treatment.
Topics: Adenosine; Antineoplastic Agents; Benzamides; Biphenyl Compounds; Cell Cycle; Cell Transformation, Neoplastic; Clinical Trials as Topic; Combined Modality Therapy; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Histone Code; Histones; Humans; Methylation; Morpholines; Multicenter Studies as Topic; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Polycomb Repressive Complex 2; Pyridones; Structure-Activity Relationship; Transcriptional Activation; Tumor Microenvironment | 2020 |
Novel insights into the interplay between m
Topics: Adenosine; Animals; Carcinogenesis; Disease Susceptibility; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Humans; Methylation; MicroRNAs; Neoplasms; RNA Interference; RNA, Circular; RNA, Long Noncoding; RNA, Messenger; RNA, Untranslated | 2020 |
m6A RNA Methylation: Ramifications for Gene Expression and Human Health.
Topics: Adenosine; Animals; Gene Expression Regulation; Health; Humans; Methylation; Nuclear Proteins; RNA; RNA, Messenger | 2020 |
Roles of METTL3 in cancer: mechanisms and therapeutic targeting.
Topics: Adenosine; Antineoplastic Agents; Binding, Competitive; Carcinogens; Drug Design; Drug Screening Assays, Antitumor; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Models, Molecular; Molecular Targeted Therapy; Neoplasm Proteins; Neoplasms; Oncogenes; Protein Conformation; Protein Domains; Recombinant Fusion Proteins; RNA Processing, Post-Transcriptional; RNA, Neoplasm; Substrate Specificity; Tumor Suppressor Proteins | 2020 |
Surmounting cancer drug resistance: New insights from the perspective of N
Topics: Adenosine; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Disease Models, Animal; DNA Damage; DNA Repair; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Immune Checkpoint Inhibitors; Methylation; Neoplasms; Protein Kinase Inhibitors; RNA Processing, Post-Transcriptional; Treatment Outcome; Tumor Microenvironment | 2020 |
Insight into m
Topics: Adenosine; Animals; Disease Susceptibility; Gene Expression Regulation; Humans; Methylation; RNA Processing, Post-Transcriptional; RNA Splicing; RNA Stability; RNA Transport; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic | 2020 |
m
Topics: Adenosine; Cardiovascular Diseases; Disease Susceptibility; Epigenesis, Genetic; Gene Expression Regulation; Humans; Methylation; Molecular Targeted Therapy; RNA | 2020 |
Epigenetic regulation of adipose tissue expansion and adipogenesis by N
Topics: Adenosine; Adipogenesis; Adipose Tissue; Epigenesis, Genetic; Humans; Methylation; RNA Processing, Post-Transcriptional | 2021 |
m6A modification in RNA: biogenesis, functions and roles in gliomas.
Topics: Adenosine; Epigenesis, Genetic; Humans; Methylation; Prognosis; RNA; RNA Processing, Post-Transcriptional; Sequence Analysis, RNA | 2020 |
Epitranscriptomic regulation by m
Topics: Adenosine; Brain; Circadian Rhythm; Cognition; Epigenomics; Gene Expression Regulation; Humans; Methylation; Nervous System Diseases; Neurogenesis; Neuronal Plasticity; RNA; RNA, Messenger; Stress, Physiological | 2020 |
N
Topics: Adenosine; Animals; Disease Progression; Humans; Methylation; Methyltransferases; Neoplasms; RNA, Messenger | 2020 |
An Emerging Role of m6A in Memory: A Case for Translational Priming.
Topics: Adenosine; Animals; Brain; Epigenesis, Genetic; Gene Expression Regulation; Humans; Mammals; Memory; Methylation; Peptide Chain Initiation, Translational; RNA; RNA, Messenger | 2020 |
Role of m6A RNA methylation in cardiovascular disease (Review).
Topics: Adenosine; Animals; Cardiovascular Diseases; Humans; Methylation; Polymorphism, Single Nucleotide; RNA; RNA-Binding Proteins | 2020 |
Aberrant regulation of RNA methylation during spermatogenesis.
Topics: Adenosine; Animals; Male; Methylation; RNA Processing, Post-Transcriptional; Spermatogenesis | 2021 |
Advances in the profiling of N
Topics: Adenosine; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Methylation; RNA, Messenger | 2020 |
[Research Advances of m⁶A RNA Methylation in Non-small Cell Lung Cancer].
Topics: Adenosine; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Methylation; Molecular Targeted Therapy; RNA, Messenger | 2020 |
Novel Insights Into the Role of N6-Methyladenosine RNA Modification in Bone Pathophysiology.
Topics: Adenosine; Bone and Bones; Cartilage; Humans; Methylation; MicroRNAs; Neoplasms; RNA; RNA, Long Noncoding; RNA, Messenger | 2021 |
Epitranscriptomic(N6-methyladenosine) Modification of Viral RNA and Virus-Host Interactions.
Topics: Adenosine; Methylation; Methyltransferases; RNA, Viral | 2020 |
The N6-methyladenosine RNA modification in acute myeloid leukemia.
Topics: Adenosine; Animals; Biomarkers; Disease Management; Disease Susceptibility; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Methylation; RNA | 2021 |
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Amino Acid Motifs; Animals; Crystallography, X-Ray; Databases, Protein; Homocysteine; Humans; Ligands; Methylation; Molecular Conformation; NAD; Nucleotides; Protein Binding; Protein Domains; Protein Folding; Software | 2020 |
The role of m6A modification in the biological functions and diseases.
Topics: Adenosine; Epigenesis, Genetic; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Methylation; Methyltransferases; Neoplasms; Nerve Tissue Proteins; RNA Processing, Post-Transcriptional; RNA Splicing Factors; RNA-Binding Proteins | 2021 |
N6-Adenosine Methylation (m
Topics: Adenosine; Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Methylation; RNA, Messenger | 2021 |
Effects of m6A modifications on signaling pathways in human cancer (Review).
Topics: Adenosine; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; RNA Processing, Post-Transcriptional; Signal Transduction | 2021 |
Mapping messenger RNA methylations at single base resolution.
Topics: Adenosine; Aldehydes; Amines; Base Sequence; Cell Line; Epigenesis, Genetic; Gene Expression Regulation; Guanosine; Humans; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger; Single Molecule Imaging; Staining and Labeling | 2021 |
Chromatin and transcriptional regulation by reversible RNA methylation.
Topics: Adenosine; Chromatin; Gene Expression Regulation; Humans; Methylation; RNA | 2021 |
N
Topics: Adenosine; Humans; Methylation; Neoplasms; RNA; RNA, Messenger | 2021 |
RNA modifications in cardiovascular diseases, the potential therapeutic targets.
Topics: Adenosine; Animals; Atherosclerosis; Cardiovascular Diseases; Coronary Disease; Epigenesis, Genetic; Fibrosis; Gene Expression Profiling; Gene Expression Regulation; Heart Failure; Humans; Hypertension, Pulmonary; Hypertrophy; Metabolic Syndrome; Methylation; Mice; Microcirculation; Myocardium; Regeneration; Reperfusion Injury; RNA; RNA Processing, Post-Transcriptional; RNA, Untranslated; Transcriptome | 2021 |
Epigenetic regulation of N6-methyladenosine modifications in obesity.
Topics: Adenosine; Adipogenesis; Animals; Epigenesis, Genetic; Humans; Methylation; Obesity; RNA Processing, Post-Transcriptional | 2021 |
Relevance of N6-methyladenosine regulators for transcriptome: Implications for development and the cardiovascular system.
Topics: Adenosine; Animals; Biomarkers; Cardiovascular Diseases; Cardiovascular System; Homeostasis; Humans; Methylation; MicroRNAs; RNA Processing, Post-Transcriptional; RNA, Long Noncoding; RNA, Messenger; Transcriptome | 2021 |
Regulation of RNA N
Topics: Adenosine; Animals; Cell Differentiation; Epigenesis, Genetic; Humans; Methylation; Muscle Development; Muscle, Skeletal; Muscular Diseases; RNA | 2021 |
Physio-pathological effects of m6A modification and its potential contribution to melanoma.
Topics: Adenosine; Gene Expression; Humans; Melanoma; Methylation; Methyltransferases; Mutation; Oxidoreductases, N-Demethylating; Proto-Oncogene Proteins B-raf; RNA Processing, Post-Transcriptional; RNA Splicing Factors; RNA, Messenger; Skin Neoplasms | 2021 |
Interactions between m6A modification and miRNAs in malignant tumors.
Topics: Adenosine; Animals; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; MicroRNAs; Neoplasms; RNA Processing, Post-Transcriptional | 2021 |
m
Topics: Adenosine; Humans; Lung Neoplasms; Methylation; RNA; RNA, Long Noncoding; RNA, Messenger | 2021 |
RNA modifications in hematopoietic malignancies: a new research frontier.
Topics: Adenosine; Hematologic Neoplasms; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Methylation; RNA Processing, Post-Transcriptional; RNA, Neoplasm | 2021 |
From A to m
Topics: Adenosine; Animals; Epigenesis, Genetic; Gene Expression Regulation, Viral; Host-Pathogen Interactions; Humans; Methylation; RNA, Viral; Species Specificity; Transcription, Genetic; Virus Replication | 2021 |
The Emerging Roles of RNA m
Topics: Adenosine; Animals; Demethylation; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; RNA | 2021 |
RNA methylation in mammalian development and cancer.
Topics: Adenosine; Animals; Cell Differentiation; Methylation; Neoplasms; RNA | 2021 |
The role m
Topics: Adenosine; Animals; Central Nervous System; Glioma; Humans; Methylation; Models, Biological; RNA | 2021 |
Regulatory effect of m
Topics: Adenosine; Humans; Methylation; Methyltransferases; RNA, Viral; Viruses | 2021 |
The role of N6-methyladenosine (m6A) in eye diseases.
Topics: Adenosine; Epigenesis, Genetic; Eye Diseases; Humans; Methylation; Methyltransferases; RNA; RNA, Messenger | 2021 |
Decoding m
Topics: Adenosine; Animals; Gene Expression; Humans; Methylation; Neoplasms; Protein Domains; RNA Processing, Post-Transcriptional; RNA, Messenger | 2021 |
N
Topics: Adenosine; Methylation; RNA; RNA, Messenger; RNA, Untranslated | 2022 |
Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions.
Topics: Adenosine; Gene Expression Regulation; Humans; Methylation; Protein Biosynthesis; RNA Splicing; RNA Stability; RNA Transport; RNA, Circular; Transcription, Genetic | 2021 |
N6-methyladenosine RNA modification and its interaction with regulatory non-coding RNAs in colorectal cancer.
Topics: Adenosine; Animals; Biomarkers, Tumor; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Methylation; MicroRNAs; Molecular Targeted Therapy; RNA, Circular; RNA, Long Noncoding; RNA, Messenger; RNA, Untranslated | 2021 |
Roles of M
Topics: Adenosine; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Methylation; Methyltransferases | 2022 |
[Research Advance of the Roles of N6-methyladenosine in the Regulation of Hematopoiesis--Review].
Topics: Adenosine; Hematopoiesis; Humans; Methylation; RNA | 2021 |
RNA N6-methyladenosine in nonocular and ocular disease.
Topics: Adenosine; Eye Diseases; Humans; Methylation; Methyltransferases; RNA; RNA, Messenger | 2022 |
N6-Methyladenosine RNA Modification in the Tumor Immune Microenvironment: Novel Implications for Immunotherapy.
Topics: Adenosine; Animals; Humans; Immunotherapy; Methylation; Neoplasms; RNA; Tumor Microenvironment | 2021 |
The role of m6A RNA methylation in cancer metabolism.
Topics: Adenosine; Animals; Biomarkers; Disease Management; Disease Susceptibility; Energy Metabolism; Gene Expression Regulation, Neoplastic; Humans; Methylation; Mitochondria; Neoplasms; RNA; RNA Processing, Post-Transcriptional; RNA, Circular; RNA, Messenger; RNA, Untranslated; Signal Transduction; Transcription Factors | 2022 |
Advances in the functional roles of N6-methyladenosine modification in cancer progression: mechanisms and clinical implications.
Topics: Adenosine; Humans; Methylation; Neoplasms; RNA, Messenger | 2022 |
N6-methyladenosine and Neurological Diseases.
Topics: Adenosine; Epigenesis, Genetic; Methylation; Methyltransferases | 2022 |
Insights into N6-methyladenosine and programmed cell death in cancer.
Topics: Adenosine; Apoptosis; Humans; Methylation; Neoplasms | 2022 |
Emerging role of m6A modification in osteogenesis of stem cells.
Topics: Adenosine; Cell Differentiation; Methylation; Osteogenesis; Stem Cells | 2022 |
Emerging role of m
Topics: Active Transport, Cell Nucleus; Adenosine; Cardiovascular Diseases; Humans; Methylation; RNA | 2022 |
m
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Biological Phenomena; Crops, Agricultural; Gene Expression Regulation; Humans; Methylation; Plants; RNA, Messenger | 2022 |
Role of N6-methyladenosine modification in pathogenesis of ischemic stroke.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Humans; Ischemic Stroke; Methylation; Methyltransferases; RNA, Messenger | 2022 |
The regulatory role of N
Topics: Adenosine; Humans; Methylation; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger; Viruses | 2022 |
The roles of N6-methyladenosine methylation in the regulation of bone development, bone remodeling and osteoporosis.
Topics: Adenosine; Bone Development; Bone Remodeling; Humans; Methylation; Osteoporosis; RNA, Messenger | 2022 |
Emerging Roles and Mechanism of m6A Methylation in Cardiometabolic Diseases.
Topics: Adenosine; Cardiovascular Diseases; Humans; Methylation; Methyltransferases; RNA, Messenger | 2022 |
Epitranscriptomic dynamics in brain development and disease.
Topics: Adenosine; Brain; Epigenomics; Humans; Methylation; RNA | 2022 |
The crucial mechanism and therapeutic implication of RNA methylation in bone pathophysiology.
Topics: Adenosine; Bone Diseases; Humans; Methylation; RNA | 2022 |
m
Topics: Adenosine; Gene Expression Regulation; Humans; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger | 2022 |
Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Humans; Leukemia, Myeloid, Acute; Methylation; Mice; RNA; RNA, Messenger | 2022 |
The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer.
Topics: Adenosine; Humans; Methylation; Neoplasms; RNA-Binding Proteins; RNA, Messenger | 2022 |
The Potential Value of m6A RNA Methylation in the Development of Cancers Focus on Malignant Glioma.
Topics: Adenosine; Glioblastoma; Glioma; Humans; Methylation; RNA; Tumor Microenvironment | 2022 |
One Stone, Two Birds: N6-Methyladenosine RNA Modification in Leukemia Stem Cells and the Tumor Immune Microenvironment in Acute Myeloid Leukemia.
Topics: Adenosine; Humans; Leukemia, Myeloid, Acute; Methylation; RNA; Stem Cells; Tumor Microenvironment | 2022 |
Novel insights into the interaction between N6-methyladenosine methylation and noncoding RNAs in musculoskeletal disorders.
Topics: Adenosine; Bone Neoplasms; Humans; Intervertebral Disc Degeneration; Methylation; MicroRNAs; Osteoarthritis; Osteoporosis; Osteosarcoma; RNA, Circular; RNA, Long Noncoding; RNA, Untranslated | 2022 |
m
Topics: Adenosine; Mechanistic Target of Rapamycin Complex 1; Methylation; RNA, Messenger; Signal Transduction; Transforming Growth Factor beta | 2022 |
METTL3 plays a crucial function in multiple biological processes.
Topics: Adenosine; Biological Phenomena; Humans; Methylation; Methyltransferases; RNA, Messenger | 2022 |
N6-methyladenosine modification and metabolic reprogramming of digestive system malignancies.
Topics: Adenosine; Digestive System Neoplasms; Humans; Methylation; RNA; Tumor Microenvironment | 2022 |
N6-methyladenosine (m6A) modification in gynecological malignancies.
Topics: Adenosine; Female; Genital Neoplasms, Female; Humans; Methylation; RNA | 2022 |
Mutual regulation between N6-methyladenosine (m6A) modification and circular RNAs in cancer: impacts on therapeutic resistance.
Topics: Adenosine; Drug Resistance, Neoplasm; Humans; Methylation; Neoplasms; RNA, Circular | 2022 |
Potential Impact of N6-Methyladenosine RNA Methylation on Vision Function and the Pathological Processes of Ocular Diseases: New Discoveries and Future Perspectives.
Topics: Adenosine; Methylation; RNA; RNA Processing, Post-Transcriptional | 2022 |
The role of N6-methyladenosine methylation in environmental exposure-induced health damage.
Topics: Adenosine; Environmental Exposure; Environmental Health; Environmental Pollutants; Methylation; Methyltransferases; Particulate Matter; Reactive Oxygen Species | 2022 |
Research progress of m
Topics: Adenosine; Animals; Growth and Development; Humans; Methylation; Neoplasms; RNA; RNA, Messenger | 2022 |
The Role of RNA m
Topics: Adenosine; Glycolysis; Humans; Methylation; Neoplasms; RNA; Tumor Microenvironment | 2023 |
Impact of N6-methyladenosine (m
Topics: Adenosine; Humans; Methylation; Methyltransferases; Neoplasms | 2022 |
The effects of RNA methylation on immune cells development and function.
Topics: 5-Methylcytosine; Adenosine; Methylation; Methyltransferases; RNA | 2022 |
Implications of m6A methylation and microbiota interaction in non-small cell lung cancer: From basics to therapeutics.
Topics: Adenosine; Carcinoma, Non-Small-Cell Lung; Humans; Lung Neoplasms; Methylation; Microbiota; RNA | 2022 |
The role of RNA m6A methylation in lipid metabolism.
Topics: Adenosine; Animals; Lipid Metabolism; Lipids; Mammals; Methylation; Methyltransferases; RNA, Messenger | 2022 |
[Research Progress of m6A Methylation Modification in Hematological Tumors--Review].
Topics: Adenosine; Epigenesis, Genetic; Hematologic Neoplasms; Humans; Methylation; Neoplasms; RNA, Messenger | 2022 |
Critical functions of N
Topics: Adenosine; Methylation; RNA, Messenger; T-Lymphocytes | 2023 |
Emerging role of N6-methyladenosine RNA methylation in lung diseases.
Topics: Adenosine; Asthma; Humans; Lung Diseases; Lung Neoplasms; Methylation; RNA; RNA, Messenger | 2022 |
The Role of N
Topics: Adenosine; Biomarkers; Methylation; RNA, Messenger | 2022 |
[Research advances on the effects of RNA N
Topics: Adenosine; Methylation; Methyltransferases; RNA | 2022 |
N6-methyladenosine functions and its role in skin cancer.
Topics: Adenosine; Animals; Humans; Mammals; Methylation; Skin Neoplasms | 2023 |
m6A readers, writers, erasers, and the m6A epitranscriptome in breast cancer.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Breast Neoplasms; Female; Humans; Methylation; Methyltransferases; RNA; RNA-Binding Proteins; RNA, Messenger | 2023 |
Roles of m
Topics: Adenosine; Humans; Methylation; Mouth Neoplasms; RNA, Messenger | 2023 |
Biological roles of the RNA m
Topics: Adenosine; Humans; Methylation; Neoplasms; RNA; RNA, Messenger | 2022 |
RNA modifications in cardiovascular health and disease.
Topics: Adenosine; Animals; Cardiovascular Diseases; Humans; Mammals; Methylation; Nucleotides; RNA | 2023 |
From form to function: m
Topics: Adenosine; Epigenesis, Genetic; Humans; Methylation; Protein Processing, Post-Translational; RNA, Messenger | 2023 |
RNA methylation in vascular disease: a systematic review.
Topics: Adenosine; Humans; Methylation; RNA; Vascular Diseases | 2022 |
RNA Epigenetics in Chronic Lung Diseases.
Topics: Adenosine; Epigenesis, Genetic; Humans; Lung Neoplasms; Methylation; RNA | 2022 |
Emerging Mutual Regulatory Roles between m
Topics: Adenosine; Animals; Carrier Proteins; Epigenesis, Genetic; Mammals; Methylation; Methyltransferases; MicroRNAs; Transcription Factors | 2023 |
RNA N6-methyladenosine methylation and skin diseases.
Topics: Adenosine; Humans; Methylation; Methyltransferases; RNA; RNA, Messenger; Skin Diseases | 2023 |
RNA m6A methylation across the transcriptome.
Topics: Adenosine; Animals; Mammals; Methylation; Methyltransferases; RNA; Transcriptome | 2023 |
Regulation of Gene Expression by m6Am RNA Modification.
Topics: Adenosine; Animals; Gene Expression Regulation; Mammals; Methylation; RNA; RNA Splicing; RNA, Messenger; RNA, Small Nuclear | 2023 |
m
Topics: Adenosine; Carcinogenesis; Humans; Immune Evasion; Methylation; Tumor Microenvironment | 2023 |
The diverse role of RNA methylation in esophageal cancer.
Topics: Adenosine; Esophageal Neoplasms; Humans; Methylation; MicroRNAs; RNA; RNA, Messenger; Tumor Microenvironment | 2023 |
Research Progress of m
Topics: Adenosine; Carcinoma, Squamous Cell; Humans; Methylation; Methyltransferases; RNA; Skin Diseases; Skin Neoplasms | 2023 |
The roles and mechanism of m
Topics: Adenosine; Humans; Methylation; Methyltransferases; Neoplasms; RNA; Tumor Microenvironment | 2023 |
Connecting the Dots: N6-Methyladenosine (m
Topics: Adenosine; Humans; Male; Methylation; Methyltransferases; RNA Processing, Post-Transcriptional; Spermatogenesis | 2023 |
Methyltransferase-like proteins in cancer biology and potential therapeutic targeting.
Topics: Adenosine; Biology; Humans; Methylation; Methyltransferases; MicroRNAs; Neoplasms | 2023 |
N6-methyladenosine (m6A) methylation in kidney diseases: Mechanisms and therapeutic potential.
Topics: Adenosine; Humans; Kidney Diseases; Methylation; Methyltransferases; RNA | 2023 |
Emerging Roles for DNA 6mA and RNA m6A Methylation in Mammalian Genome.
Topics: Adenine; Adenosine; Animals; DNA; Mammals; Methylation; RNA | 2023 |
The roles of m6A methylation in cervical cancer: functions, molecular mechanisms, and clinical applications.
Topics: Adenosine; Cell Proliferation; Female; Humans; Methylation; RNA; Tumor Microenvironment; Uterine Cervical Neoplasms | 2023 |
1 trial(s) available for isomethyleugenol and adenosine
| Article | Year |
|---|---|
The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine.
Topics: Adenosine; Aged; Arginine; Coronary Angiography; Coronary Artery Disease; Disease Progression; Ethionine; Female; Folic Acid; Follow-Up Studies; Humans; Lysine; Male; Methylation; Middle Aged; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2013 |
831 other study(ies) available for isomethyleugenol and adenosine
| Article | Year |
|---|---|
Kinetics and mechanism of carbon-8 methylation of purine bases and nucleosides by methyl radical.
Topics: Adenine; Adenosine; Caffeine; Guanine; Guanosine; Hot Temperature; Hydrogen-Ion Concentration; Hypoxanthines; Inosine; Kinetics; Methods; Methylation; Photochemistry; Purine Nucleosides | 1977 |
Solution conformation and relative acidities of the sugar hydroxyls of the O'-methylated derivates of the antimetabolite 9-beta-D-xylofuranosyladenine.
Topics: Adenosine; Antimetabolites; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Methylation; Molecular Conformation; Protons; Xylose | 1978 |
Maturation of a hypermodified nucleoside in transfer RNA.
Topics: Adenosine; Amino Acids; Culture Media; Cysteine; Cytokinins; Escherichia coli; Methionine; Methylation; Nucleosides; RNA, Bacterial; RNA, Transfer | 1975 |
[5-methylthioadenosine phosphorylase from C.acidophila. 2. Identification and characterization of reaction products].
Topics: Adenosine; Bacteria; Centrifugation; Hot Temperature; Indicators and Reagents; Methylation; Pentosyltransferases; Phosphorylation; Purine-Nucleoside Phosphorylase; Thionucleosides | 1978 |
Methylated nucleotides block 5'-terminus of vaccinia virus messenger RNA.
Topics: Adenosine; Alkaline Phosphatase; Base Sequence; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer; Diphosphates; Electrophoresis; Guanosine; Methylation; Phosphorus Radioisotopes; RNA, Messenger; RNA, Viral; S-Adenosylmethionine; Tritium; Vaccinia virus | 1975 |
Methylated nucleotides block 5' terminus of HeLa cell messenger RNA.
Topics: Adenosine; Alkaline Phosphatase; Base Sequence; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Chromatography, Thin Layer; Electrophoresis; Guanosine; HeLa Cells; Humans; Hydrolysis; Methionine; Methylation; Nucleotides; Phosphoric Diester Hydrolases; RNA, Messenger; RNA, Neoplasm; Tritium; Uridine | 1975 |
The 5' terminal structure of the methylated mRNA synthesized in vitro by vesicular stomatitis virus.
Topics: Adenosine; Adenosine Triphosphate; Alkaline Phosphatase; Cell-Free System; Chromatography, DEAE-Cellulose; Chromatography, Paper; Diphosphates; DNA-Directed RNA Polymerases; Electrophoresis, Paper; Guanosine; Guanosine Triphosphate; Methylation; Oligonucleotides; Phosphoric Diester Hydrolases; Pyrophosphatases; Ribonucleases; RNA, Messenger; RNA, Viral; S-Adenosylmethionine; Vesicular stomatitis Indiana virus | 1975 |
Methylated and blocked 5' termini in vesicular stomatitis virus in vivo mRNAs.
Topics: Adenosine; Alkaline Phosphatase; Chromatography, DEAE-Cellulose; Chromatography, Paper; Diphosphates; Electrophoresis, Paper; Genes; Guanosine; Methylation; Oligonucleotides; Phosphoric Diester Hydrolases; Pyrophosphatases; Ribonucleases; RNA, Messenger; RNA, Viral; Vesicular stomatitis Indiana virus | 1975 |
5' nucleotide sequence of sindbis viral RNA.
Topics: Adenosine; Alkalies; Alkaline Phosphatase; Base Sequence; Chromatography, DEAE-Cellulose; Cytidine; Electrophoresis, Paper; Guanosine; Methylation; Molecular Weight; Nucleotides; Phosphoric Diester Hydrolases; Ribonucleases; RNA, Viral; Sindbis Virus; Uridine | 1975 |
In vivo methylation of vesicular stomatitis virus and its host-cell messenger RNA species.
Topics: Adenosine; Base Sequence; Cell Line; Guanine Nucleotides; HeLa Cells; Methylation; Oligonucleotides; RNA, Messenger; RNA, Viral; Transcription, Genetic; Vesicular stomatitis Indiana virus | 1976 |
Evidence of methylation of B77 avian sarcoma virus genome RNA subunits.
Topics: Adenosine; Animals; Avian Sarcoma Viruses; Base Sequence; Chick Embryo; Culture Techniques; Guanine Nucleotides; Hot Temperature; Methylation; Nucleic Acid Denaturation; RNA, Messenger; RNA, Viral | 1976 |
5'-Terminal and internal methylated nucleosides in herpes simplex virus type 1 mRNA.
Topics: Adenosine; Base Sequence; Cytidine; Guanosine; HeLa Cells; Methylation; Nucleosides; Poly A; Polyribosomes; RNA, Messenger; RNA, Viral; Simplexvirus; Uridine | 1977 |
Decreased rate of S-adenosyl-L-homocysteine metabolism: an early event related to transformation in cells infected with Rous sarcoma virus.
Topics: Adenosine; Adenosine Deaminase; Amino Acid Oxidoreductases; Animals; Avian Sarcoma Viruses; Cell Line; Cell Transformation, Neoplastic; Homocysteine; Hydrolases; Methylation; Neoplasm Proteins; Proteins; S-Adenosylhomocysteine; Tumor Virus Infections | 1977 |
Capping structures of simian virus 40 19S and 16S mRNAs.
Topics: Adenosine; Base Sequence; Guanosine; Methylation; Molecular Weight; RNA, Messenger; RNA, Viral; Simian virus 40 | 1977 |
S-adenosylhomocysteine toxicity in normal and adenosine kinase-deficient lymphoblasts of human origin.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Cell Division; Cell Line; Homocysteine; Humans; Lactones; Lymphocytes; Methylation; Phosphotransferases; S-Adenosylhomocysteine | 1979 |
Methylation of nuclear simian virus 40 RNAs.
Topics: Adenosine; Animals; Cell Line; Cell Nucleus; DNA Restriction Enzymes; DNA, Viral; Haplorhini; Kidney; Methylation; Nucleic Acid Hybridization; RNA Caps; RNA, Messenger; RNA, Viral; Simian virus 40; Transcription, Genetic | 1979 |
Free-radical intermediates produced from the one-electron reduction of purine, adenine, and guanine derivatives in water.
Topics: Adenosine; Electrons; Free Radicals; Guanosine; Hydrogen-Ion Concentration; Methylation; Oxidation-Reduction; Purines; Water | 1975 |
Cordycepin and xylosyladenine: inhibitors of methylation of nuclear RNA.
Topics: Adenosine; Animals; Cell Nucleus; Deoxyadenosines; Leukemia L1210; Methylation; Mice; RNA, Neoplasm; Xylose | 1978 |
Evidence that xylosyladenine affects methylation by inhibition of S-adenosyl-L-methionine synthesis.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Nucleus; Coformycin; Deoxyadenosines; In Vitro Techniques; Leukemia L1210; Methylation; Mice; RNA, Neoplasm; S-Adenosylmethionine; Xylose | 1979 |
S-adenosyl-L-homocysteine as a stimulator of viral RNA synthesis by two distinct cytoplasmic polyhedrosis viruses.
Topics: Adenosine; Cell-Free System; Homocysteine; Insect Viruses; Methylation; RNA, Messenger; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; Stimulation, Chemical | 1978 |
Occurrence of 1-methyladenosine and absence of ribothymidine in transfer ribonucleic acid of Mycobacterium smegmatis.
Topics: Adenosine; Escherichia coli; Methylation; Mycobacterium; RNA, Bacterial; RNA, Transfer; Species Specificity; Thymidine; tRNA Methyltransferases | 1979 |
Inhibition of methylation by adenosine in adenosine deaminase-inhibited, phytohemagglutinin-stimulated human lymphocytes.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; DNA; Homocysteine; Humans; Lymphocyte Activation; Methylation; Nucleoside Deaminases; Phytohemagglutinins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1979 |
Methylated 5'-terminal caps of adenovirus type 2 early mRNA: evidence for at least six 5'-termini.
Topics: Adenosine; Adenoviruses, Human; Electrophoresis; Guanosine; Methylation; Nucleosides; Poly A; Ribonucleases; RNA, Messenger; RNA, Viral; Uridine | 1979 |
N-6-methyl-adenosine in adenovirus type 2 nuclear RNA is conserved in the formation of messenger RNA.
Topics: Adenosine; Adenoviridae; Cell Nucleus; Cytoplasm; Methionine; Methylation; Models, Biological; Nucleic Acid Hybridization; RNA, Messenger; RNA, Viral; Uridine | 1979 |
In vitro methylation of adenosine residues in reovirus RNA.
Topics: Adenosine; Chymotrypsin; L Cells; Mammalian orthoreovirus 3; Manganese; Methylation; Methyltransferases; Oligonucleotides; Reoviridae; RNA, Messenger; RNA, Viral | 1978 |
The absolute frequency of labeled N-6-methyladenosine in HeLa cell messenger RNA decreases with label time.
Topics: Adenosine; Cytoplasm; HeLa Cells; Methylation; Ribonucleotides; RNA, Messenger; Time Factors | 1978 |
Biosynthetic pathway of ribothymidine in B. subtilis and M. lysodeikticus involving different coenzymes for transfer RNA and ribosomal RNA.
Topics: Adenosine; Bacillus subtilis; Borohydrides; Coenzymes; Escherichia coli; Methionine; Methylation; Methylguanidine; Micrococcus; Ribonucleosides; RNA, Ribosomal; RNA, Transfer; S-Adenosylmethionine; Tetrahydrofolates; Uridine | 1975 |
Undermethylated transfer ribonucleic acid from a relaxed strain of Bacillus subtilis: construction of the strain and analysis of the transfer ribonucleic acid.
Topics: Adenosine; Amino Acids; Bacillus subtilis; Cytidine; Electron Transport; Guanosine; Methionine; Methylation; Mutation; Pseudouridine; Rifampin; RNA, Bacterial; RNA, Transfer; Transformation, Genetic; Uridine | 1976 |
Modified nucleosides of Bacillus subtilis transfer ribonucleic acids.
Topics: Adenosine; Bacillus subtilis; Cytidine; Guanosine; Methylation; Nucleosides; RNA, Bacterial; RNA, Transfer; Thiouridine; Uridine | 1976 |
Histone mRNAs contain blocked and methylated 5' terminal sequences but lack methylated nucleosides at internal positions.
Topics: Adenosine; Guanosine; HeLa Cells; Histones; Methylation; Nucleosides; RNA, Messenger; Uridine | 1977 |
Methylated 5'-terminal sequences of vaccinia virus mRNA species made in vivo at early and late times after infection.
Topics: Adenosine; Base Sequence; Guanine Nucleotides; Guanosine; HeLa Cells; Methylation; RNA, Messenger; RNA, Viral; Vaccinia virus | 1977 |
Preparation of O'-METHYL derivatives of 9-beta-D-xylofuranosyladenine.
Topics: Adenosine; Animals; Cattle; Methods; Methylation | 1977 |
Nucleic acid related compounds. 20. Sugar, base doubly modified nucleosides at the 5'-terminal "cap" of mRNAs and in nuclear RNA.
Topics: Adenosine; Cell Nucleus; Chemical Phenomena; Chemistry; Mass Spectrometry; Methylation; Optical Rotation; RNA, Messenger; Spectrophotometry, Ultraviolet | 1976 |
Methylation of adenosine in strongly alkaline medium: Preparation and Properties of o'-methyl derivatives of adenosine and N6-methyladenosine.
Topics: Adenosine; Chemical Phenomena; Chemistry; Magnetic Resonance Spectroscopy; Methylation; Molecular Conformation; Structure-Activity Relationship | 1976 |
Methylated blocked 5' terminal sequences of sea urchin embryo messenger RNA classes containing and lacking poly(A).
Topics: Adenosine; Animals; Base Sequence; Cytidine; Embryo, Nonmammalian; Guanosine; Histones; Methylation; Poly A; RNA, Messenger; Sea Urchins; Uridine | 1976 |
Methylated constituents of poly(A)- and poly(A)+ polyribosomal RNA of sea urchin embryos.
Topics: Adenosine; Animals; Embryo, Nonmammalian; Guanosine; Methylation; Poly A; Polyribosomes; RNA, Ribosomal; Sea Urchins | 1976 |
Human leukemic cells: characteristics of modified methylated minor bases of low molecular weight ribonucleic acids.
Topics: Adenosine; Autoradiography; Cell Fractionation; Cells, Cultured; Chromatography, Gel; Chromatography, Thin Layer; Cytidine; Electrophoresis, Polyacrylamide Gel; Female; Fluorometry; Guanosine; Humans; Infectious Mononucleosis; Leukemia, Lymphoid; Lymphocytes; Male; Methylation; Molecular Weight; Ribonucleosides; RNA; RNA, Ribosomal; RNA, Transfer; Uridine | 1975 |
Tetrahydrofolic acid: an inhibitor of the methyltetrahydrofolic acid-mediated methylation of indolethylamines.
Topics: Adenosine; Animals; Binding, Competitive; Bufotenin; Ethylamines; Homocysteine; Indoles; Lung; Methylation; Methyltransferases; N,N-Dimethyltryptamine; Rabbits; S-Adenosylmethionine; Serotonin; Tetrahydrofolates | 1975 |
Tubercidin and isopropylureidopurine--inhibitors of ribothymidine synthesis in vitro.
Topics: Adenosine; Carbon Radioisotopes; Escherichia coli; Kinetics; Methylation; Purines; Ribonucleosides; RNA, Transfer; S-Adenosylmethionine; Thymidine; Tubercidin | 1975 |
Separation of the methylated nucleoside consituents of ribonucleic acid by two-dimensional thin-layer chromatography.
Topics: Adenosine; Chromatography, Thin Layer; Cytidine; Guanosine; Methylation; Ribonucleosides; Solvents; Uridine | 1975 |
N6, O2'-dimethyladenosine a novel methylated ribonucleoside next to the 5' terminal of animal cell and virus mRNAs.
Topics: Adenosine; Adenoviridae; HeLa Cells; L Cells; Methylation; Ribonucleosides; RNA, Messenger; RNA, Viral | 1975 |
The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminus.
Topics: Adenine; Adenosine; Alkaline Phosphatase; Animals; Base Sequence; Chromatography, Ion Exchange; L Cells; Methionine; Methylation; Mice; Nucleotides; Nucleotidyltransferases; Oligonucleotides; Polyribosomes; RNA, Messenger; Uridine | 1975 |
Effect of site-specific methylation on DNA modification methyltransferases and restriction endonucleases.
Topics: Adenosine; Base Sequence; Cytosine; DNA; DNA Modification Methylases; DNA Restriction Enzymes; Escherichia coli; Methylation; Molecular Sequence Data | 1992 |
Effect of methylation inhibitors on gene expression in HL-60 cells.
Topics: Adenosine; Cell Differentiation; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Methylation; Poly A; RNA, Messenger; RNA, Neoplasm; Tretinoin; Tubercidin; Tumor Cells, Cultured | 1992 |
Antiretroviral activity of mechanism-based irreversible inhibitors of S-adenosylhomocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Hydrolases; Methylation; Mice; Moloney murine leukemia virus; RNA; S-Adenosylhomocysteine | 1992 |
Involvement of cyclic adenosine 3',5'-monophosphate in methylation during 1-methyladenine production by starfish ovarian follicle cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Animals; Concanavalin A; Cyclic AMP; Female; Methionine; Methionine Adenosyltransferase; Methylation; Ovarian Follicle; Starfish; Trypsin | 1992 |
Purification and biochemical characterization of the EcaI DNA methyltransferase.
Topics: Adenosine; Base Sequence; Binding, Competitive; Catalysis; Chemical Phenomena; Chemistry, Physical; DNA; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Methylation; Molecular Sequence Data; Plasmids; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Temperature | 1992 |
Trypanosoma brucei spliced-leader RNA methylations are required for trans splicing in vivo.
Topics: Adenosine; Animals; Antiprotozoal Agents; Blotting, Northern; Kinetics; Methylation; Ribonucleoproteins; RNA Precursors; RNA Splicing; RNA, Protozoan; Trypanosoma brucei brucei | 1992 |
Is there an association between an increase in c-myc RNA steady state levels and c-myc methylation in HL-60 cells treated with 3-deaza-(+/-)-aristeromycin, an indirect inhibitor of methylation?
Topics: Adenosine; Cell Nucleus; DNA; Genes, myc; Humans; Methylation; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Restriction Mapping; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1992 |
Acetylation and methylation of histones H3 and H4 in chicken immature erythrocytes are not directly coupled.
Topics: Acetylation; Adenosine; Animals; Chickens; Erythroid Precursor Cells; Histones; Methylation; Protein Processing, Post-Translational | 1992 |
8-Methyladenosine-substituted analogues of 2-5A: synthesis and their biological activities.
Topics: Adenine Nucleotides; Adenosine; Animals; Endoribonucleases; Kinetics; Liver Extracts; Magnetic Resonance Spectroscopy; Methylation; Oligoribonucleotides; Phosphodiesterase I; Phosphoric Diester Hydrolases; Protein Biosynthesis; Rats; RNA | 1991 |
The effect of sinefungin and synthetic analogues on RNA and DNA methyltransferases from Streptomyces.
Topics: Adenosine; Chromatography, Thin Layer; DNA; DNA Modification Methylases; Methylation; RNA, Bacterial; RNA, Ribosomal; RNA, Transfer; Streptomyces; tRNA Methyltransferases | 1991 |
Lipopolysaccharide-induced NF-kappa B activation in mouse 70Z/3 pre-B lymphocytes is inhibited by mevinolin and 5'-methylthioadenosine: roles of protein isoprenylation and carboxyl methylation reactions.
Topics: Adenosine; B-Lymphocytes; Clone Cells; Deoxyadenosines; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation; Immunoglobulin kappa-Chains; Lipopolysaccharides; Lovastatin; Membrane Proteins; Methylation; NF-kappa B; Protein Biosynthesis; Signal Transduction; Thionucleosides; Transcriptional Activation | 1992 |
Analysis of stable protein methylation in cultured cells.
Topics: Adenosine; Animals; Electrophoresis, Gel, Two-Dimensional; Histone-Lysine N-Methyltransferase; Hydrogen-Ion Concentration; In Vitro Techniques; Methylation; PC12 Cells; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Proteins; Rats | 1992 |
Leishmania donovani: antagonistic effect of S-adenosyl methionine on ultrastructural changes and growth inhibition induced by sinefungin.
Topics: Adenosine; Animals; Antiprotozoal Agents; Flagella; Golgi Apparatus; Hydrogen-Ion Concentration; Leishmania donovani; Methylation; Microscopy, Electron; Protein O-Methyltransferase; Protozoan Proteins; S-Adenosylmethionine | 1992 |
Relationship among methylation, isoprenylation, and GTP binding in 21- to 23-kDa proteins of neuroblastoma.
Topics: Adenosine; Animals; Deoxyadenosines; Dimethyl Sulfoxide; GTP-Binding Proteins; Guanosine Triphosphate; Lovastatin; Membrane Proteins; Methylation; Mevalonic Acid; Mice; Molecular Weight; Neoplasm Proteins; Neuroblastoma; Protein Processing, Post-Translational; Thionucleosides; Tumor Cells, Cultured | 1991 |
Effects of sinefungin and 5'-deoxy-5'-S-isobutyl-adenosine on lipopolysaccharide-induced proliferation and protein N-methylation of arginyl residues in murine splenic lymphocytes.
Topics: Adenosine; Animals; Antifungal Agents; Antimalarials; Arginine; Cell Division; Cells, Cultured; Deoxyadenosines; Female; Lipopolysaccharides; Lymphocytes; Methylation; Mice; Mice, Inbred BALB C; Protein-Arginine N-Methyltransferases; Spleen; Thionucleosides | 1991 |
Twenty-four-hour changes of S-adenosylmethionine, S-adenosylhomocysteine adenosine and their metabolizing enzymes in rat liver; possible physiological significance in phospholipid methylation.
Topics: Adenosine; Animals; In Vitro Techniques; Kinetics; Liver; Male; Methylation; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine | 1991 |
The effect of methylation inhibitors on citreamicin biosynthesis in Micromonospora citrea.
Topics: Adenosine; Aminopterin; Anti-Bacterial Agents; Antifungal Agents; Chromatography, High Pressure Liquid; Methylation; Micromonospora; Oxazoles | 1991 |
Amplification and detection of substrates for protein carboxyl methyltransferases in PC12 cells.
Topics: Adenosine; Animals; Cell Line; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Hydrolysis; In Vitro Techniques; Methanol; Methylation; Methyltransferases; Proteins; Rats; S-Adenosylmethionine | 1991 |
Inhibitors of membrane lipid metabolism enhance complement-mediated nucleated cell killing through distinct mechanisms.
Topics: 1-Acylglycerophosphocholine O-Acyltransferase; Acylation; Adenine; Adenosine; Adenosine Triphosphate; Animals; Carcinoma, Ehrlich Tumor; Complement C9; Complement Membrane Attack Complex; Complement System Proteins; Cytotoxicity, Immunologic; Flow Cytometry; Homocysteine; Immunosuppressive Agents; L-Lactate Dehydrogenase; Membrane Lipids; Methylation; Mice; Thimerosal | 1991 |
Methylation and demethylation reactions of guanine nucleotide-binding proteins of retinal rod outer segments.
Topics: Acetylcysteine; Adenosine; Animals; Cattle; Cysteine; GTP-Binding Proteins; In Vitro Techniques; Methylation; Molecular Weight; Rod Cell Outer Segment; S-Adenosylhomocysteine; S-Adenosylmethionine; Signal Transduction; Transducin | 1991 |
The restriction enzyme AlwNI is blocked by overlapping methylation.
Topics: 5-Methylcytosine; Adenosine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Base Sequence; Chromosome Deletion; Cloning, Molecular; Cytosine; Deoxyribonucleases, Type II Site-Specific; DNA; DNA Mutational Analysis; Methylation; Molecular Sequence Data; Plasmids; Protein Precursors | 1991 |
Protein methylases in Trypanosoma brucei brucei: activities and response to DL-alpha-difluoromethylornithine.
Topics: Adenosine; Animals; Binding Sites; Binding, Competitive; Eflornithine; Histone-Lysine N-Methyltransferase; Hydrogen-Ion Concentration; Kinetics; Methylation; Protein O-Methyltransferase; Protein-Arginine N-Methyltransferases; Rats; Substrate Specificity; Trypanosoma brucei brucei; Trypanosomiasis, African | 1991 |
Alteration of membrane phospholipid methylation by adenosine analogs does not affect T lymphocyte activation.
Topics: Adenosine; Antigens; Antigens, Differentiation, T-Lymphocyte; CD3 Complex; Cell Membrane; Cells, Cultured; Humans; Leukocytes, Mononuclear; Lipids; Lymphocyte Activation; Major Histocompatibility Complex; Methylation; Phospholipids; Receptors, Antigen, T-Cell; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors; Tritium | 1990 |
The double role of methyl donor and allosteric effector of S-adenosyl-methionine for Dam methylase of E. coli.
Topics: Adenosine; Allosteric Regulation; Base Sequence; Binding Sites; Binding, Competitive; DNA, Bacterial; Escherichia coli; Escherichia coli Proteins; Kinetics; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific); Sodium Chloride; Temperature; Thermodynamics | 1990 |
Differential cell cycle perturbation by transmethylation inhibitors.
Topics: Adenosine; Adenosylhomocysteinase; Aminoglycosides; Anti-Bacterial Agents; Cell Cycle; Enzyme Inhibitors; Flow Cytometry; Humans; Hydrolases; Interphase; Kinetics; Leukemia, Promyelocytic, Acute; Methylation; Mitosis; Tubercidin; Tumor Cells, Cultured | 1990 |
Combined modulation of S-adenosylmethionine biosynthesis and S-adenosylhomocysteine metabolism enhances inhibition of nucleic acid methylation and L1210 cell growth.
Topics: Adenosine; Animals; Cell Division; DNA, Neoplasm; Homocysteine; Leukemia L1210; Methylation; Polyamines; RNA, Neoplasm; S-Adenosylhomocysteine; S-Adenosylmethionine; Time Factors | 1990 |
Diversity of methyl acceptor proteins in rat pheochromocytoma (PC12) cells revealed after treatment with adenosine dialdehyde.
Topics: Adenosine; Adrenal Gland Neoplasms; Animals; Deoxyadenosines; Electrophoresis, Gel, Two-Dimensional; Methylation; Molecular Weight; Neoplasm Proteins; Nerve Tissue Proteins; Pheochromocytoma; Rats; S-Adenosylmethionine; Thionucleosides; Tubercidin; Tumor Cells, Cultured | 1990 |
N6-methyladenosine residues in an intron-specific region of prolactin pre-mRNA.
Topics: Adenosine; Animals; Base Sequence; Cattle; Cell Nucleus; Exons; Introns; Kinetics; Methylation; Molecular Sequence Data; Plasmids; Prolactin; Restriction Mapping; RNA Precursors; RNA, Messenger; Transcription, Genetic | 1990 |
Direct photolabeling of the EcoRII methyltransferase with S-adenosyl-L-methionine.
Topics: Adenosine; Affinity Labels; Azides; Base Sequence; Chemical Precipitation; Dithiothreitol; DNA-Cytosine Methylases; DNA, Bacterial; Escherichia coli; Kinetics; Mercaptoethanol; Methylation; Photochemistry; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Trichloroacetic Acid; Ultraviolet Rays | 1990 |
Effects of secretagogues on ATP levels and protein carboxyl methylation in rat brain synaptosomes.
Topics: Adenosine; Adenosine Triphosphate; Animals; Brain; Brain Chemistry; Calcimycin; Calcium; Chlorides; Egtazic Acid; Female; In Vitro Techniques; Manganese; Manganese Compounds; Methylation; Ouabain; Potassium; Protein Methyltransferases; Protein O-Methyltransferase; Proteins; Rats; Rats, Inbred Strains; Ruthenium Red; S-Adenosylhomocysteine; S-Adenosylmethionine; Sodium Cyanide; Synaptosomes; Tritium; Veratridine | 1986 |
Effect of some drugs on thromboplastin activity in mouse trophoblast cells in vitro and in vivo.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Adenosine; Animals; Calcium Channel Blockers; Dinoprostone; Felodipine; Female; Gallic Acid; Methylation; Mice; Monensin; Nifedipine; Nitrendipine; Pregnancy; Prostaglandins E; Thromboplastin; Trophoblasts; Tubercidin; Verapamil | 1986 |
Adenosine inhibits immunoglobulin E-dependent histamine secretion from human basophil leukocytes by two independent mechanisms.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Basophils; Cyclic AMP; Dipyridamole; Dose-Response Relationship, Drug; Histamine Release; Humans; Immunoglobulin E; Methylation; Phospholipids; S-Adenosylmethionine; Theophylline; Tubercidin | 1987 |
Blockade by methylation inhibitors of the anaphylactic response of guinea-pig lung strips.
Topics: Adenosine; Airway Resistance; Anaphylaxis; Animals; Female; Guinea Pigs; Histamine Release; Homocysteine; In Vitro Techniques; Lung; Male; Methylation; Ovalbumin; Thromboxane B2; Tubercidin | 1987 |
Inhibition of in vitro tumor cell invasion by transmethylation inhibitors.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Small Cell; Deoxyadenosines; Fibrosarcoma; Humans; Kinetics; Liver Neoplasms, Experimental; Lung Neoplasms; Melanoma, Experimental; Methylation; Neoplasm Invasiveness; Rats; Rats, Inbred Strains; Thionucleosides; Tumor Cells, Cultured | 1989 |
Lamin B methylation and assembly into the nuclear envelope.
Topics: Adenosine; Animals; Benzimidazoles; Cell Cycle; Cell Line; Chromatin; Cricetinae; Deoxyadenosines; Isoelectric Point; Lamin Type B; Lamins; Methylation; Morphogenesis; Nocodazole; Nuclear Envelope; Nuclear Proteins; Phosphorylation; Thionucleosides | 1989 |
Relationship between intracellular concentration of S-adenosylhomocysteine and inhibition of vaccinia virus replication and inhibition of murine L-929 cell growth.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antibiotics, Antineoplastic; Cell Division; Chromatography, High Pressure Liquid; Homocysteine; Hydrolases; L Cells; Methylation; Mice; S-Adenosylhomocysteine; Time Factors; Vaccinia virus; Virus Replication | 1989 |
Adenosine modulates the generation of superoxide anion by stimulated human neutrophils via interaction with a specific cell surface receptor.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Basophils; Cyclic AMP; Dipyridamole; Humans; Lymphocytes; Macrophages; Methylation; Neutrophils; Receptors, Cell Surface; Receptors, Purinergic; Superoxides; Xanthines | 1985 |
Periodate-oxidized adenosine induction of murine thymidine kinase: role of DNA methylation in the generation of tumor cell heterogeneity.
Topics: 5-Methylcytosine; Adenosine; Animals; Cells, Cultured; Cytosine; DNA, Neoplasm; Enzyme Induction; Hydroxyurea; Methylation; Mice; Oxidation-Reduction; Periodic Acid; Thymidine Kinase | 1986 |
Precise localization of m6A in Rous sarcoma virus RNA reveals clustering of methylation sites: implications for RNA processing.
Topics: Adenosine; Avian Sarcoma Viruses; Methylation; Nucleic Acid Hybridization; RNA Splicing; RNA, Viral; tRNA Methyltransferases | 1985 |
Inhibition of methylation at two internal N6-methyladenosine sites caused by GAC to GAU mutations.
Topics: Adenosine; Animals; Avian Sarcoma Viruses; Base Sequence; Chick Embryo; DNA, Recombinant; Methylation; Mutation; Nucleic Acid Hybridization; RNA, Messenger; RNA, Viral; Transfection | 1987 |
An ethA mutation in Bacillus subtilis 168 permits induction of sporulation by ethionine and increases DNA modification of bacteriophage phi 105.
Topics: Adenosine; Bacillus subtilis; Bacteriophages; DNA, Viral; Ethionine; Methionine; Methylation; Mutation; S-Adenosylmethionine; Spores, Bacterial | 1986 |
An in vitro system for accurate methylation of internal adenosine residues in messenger RNA.
Topics: Adenosine; Animals; Base Sequence; Cattle; Cell Nucleus; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; DNA-Directed RNA Polymerases; HeLa Cells; Humans; Methylation; Prolactin; Ribonucleases; RNA, Messenger; T-Phages; Transcription, Genetic | 1988 |
Processing of the bacteriophage P1 packaging site (pac) is regulated by adenine methylation.
Topics: Adenosine; Base Sequence; Coliphages; DNA, Viral; Methylation; Virion | 1988 |
DNA (cytosine) methylation in murine and human tumor cell lines treated with S-adenosylhomocysteine hydrolase inhibitors.
Topics: Adenosine; Adenosylhomocysteinase; Animals; DNA, Neoplasm; Humans; Hydrolases; Methylation; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin; Tumor Cells, Cultured | 1988 |
The transmethylation pathway as a source for adenosine in the isolated guinea-pig heart.
Topics: Adenosine; Animals; Guinea Pigs; Homocysteine; In Vitro Techniques; Methylation; Myocardium; Oxygen; Perfusion; S-Adenosylhomocysteine | 1988 |
Enhancement of biotinidase activity in mouse serum by inhibitors of methylation.
Topics: Adenine; Adenosine; Amidohydrolases; Animals; Biotinidase; Coformycin; Ethionine; Female; Liver; Methylation; Mice; Pentostatin; Vidarabine | 1987 |
Adenosine dialdehyde: a potent inhibitor of vaccinia virus multiplication in mouse L929 cells.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antiviral Agents; Hydrolases; L Cells; Methylation; Mice; RNA, Messenger; RNA, Viral; Vaccinia virus; Viral Proteins; Virus Replication | 1987 |
Periodate-oxidized adenosine inhibits the formation of dimethylselenide and trimethylselenonium ion in mice treated with selenite.
Topics: Adenosine; Animals; Inactivation, Metabolic; Kinetics; Liver; Methylation; Mice; Organometallic Compounds; Organoselenium Compounds; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenious Acid; Selenium; Selenium Compounds | 1987 |
Unequal distribution of N6-methyladenosine in influenza virus mRNAs.
Topics: Adenosine; Animals; Cell Line; Influenza A virus; Methylation; Nucleic Acid Hybridization; RNA Processing, Post-Transcriptional; RNA, Messenger | 1987 |
"Streptomyces avermitilis" mutants defective in methylation of avermectins.
Topics: Adenosine; Anthelmintics; Bacterial Proteins; Ivermectin; Methylation; Methyltransferases; Mutation; Streptomyces | 1987 |
Kinetic and electrophoretic analysis of transmethylation reactions in intact Xenopus laevis oocytes.
Topics: Adenosine; Animals; Chromatography, High Pressure Liquid; Cycloheximide; Electrophoresis, Polyacrylamide Gel; Kinetics; Methionine; Methylation; Molecular Weight; Oocytes; S-Adenosylmethionine; Xenopus laevis | 1987 |
Endocytosis of particulate and soluble IgG immune complexes: differential effects of cytoskeletal modulating agents.
Topics: Adenosine; Animals; Antigen-Antibody Complex; Colchicine; Cytochalasin B; Cytoskeleton; Endocytosis; Immunoglobulin G; Methylation; Mice; Mice, Inbred C3H; Phospholipids; Tubercidin | 1987 |
Infection with frog virus 3 allows transcription of DNA methylated at cytosine but not adenine residues.
Topics: 5-Methylcytosine; Adenosine; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA, Recombinant; Gene Expression Regulation; Iridoviridae; Methylation; Promoter Regions, Genetic; RNA Polymerase II; Transcription, Genetic; Viral Proteins | 1987 |
Priming of influenza mRNA transcription is inhibited in CHO cells treated with the methylation inhibitor, neplanocin A.
Topics: Adenosine; Animals; Antiviral Agents; Cell Line; Electrophoresis, Polyacrylamide Gel; Methylation; Nucleic Acid Hybridization; Orthomyxoviridae; RNA Caps; RNA, Messenger; RNA, Viral; Transcription, Genetic; Viral Proteins | 1987 |
Inhibition of methylation of DNA and tRNA by adenosine in an adenosine-sensitive mutant of the baby hamster kidney cell line.
Topics: Adenosine; Adenosine Kinase; Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; DNA; Kidney; Methylation; Mutation; RNA, Transfer | 1986 |
Effect of pyridoxine deficiency on phospholipid methylation in rat liver microsomes.
Topics: Adenosine; Animals; Carbon Radioisotopes; Kinetics; Male; Methylation; Microsomes, Liver; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Vitamin B 6 Deficiency | 1986 |
Carboxyl methylation of human erythrocyte band 3 in intact cells. Relation to anion transport activity.
Topics: Adenosine; Anion Exchange Protein 1, Erythrocyte; Anions; Biological Transport; Cycloleucine; Erythrocytes; Homocysteine; Humans; Methylation; Phosphates | 1986 |
Effects of the S-adenosylhomocysteine hydrolase inhibitors 3-deazaadenosine and 3-deazaaristeromycin on RNA methylation and synthesis.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Cells, Cultured; Hydrolases; Methylation; Ribonucleosides; RNA, Messenger; S-Adenosylhomocysteine; Tubercidin | 1986 |
Protein methylation and protein methylases in Leishmania donovani and Leishmania tropica promastigotes.
Topics: Adenosine; Amino Acids; Animals; Anti-Bacterial Agents; Histones; Leishmania donovani; Leishmania tropica; Methylation; Protein Methyltransferases; Proteins | 1986 |
3-Deazaneplanocin A: a new inhibitor of S-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells.
Topics: Adenosine; Adenosylhomocysteinase; Cell Line; Colonic Neoplasms; Humans; Hydrolases; Kinetics; Methionine; Methylation; RNA, Ribosomal; RNA, Transfer; S-Adenosylhomocysteine; Uridine | 1986 |
Effect of neplanocin A on differentiation, nucleic acid methylation, and c-myc mRNA expression in human promyelocytic leukemia cells.
Topics: Adenosine; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Division; Cell Line; DNA, Neoplasm; Gene Expression Regulation; Humans; Leukemia, Myeloid, Acute; Methylation; Oncogenes; RNA, Neoplasm | 1985 |
Inhibition of murine erythroleukemia cell differentiation by 3-deazaadenosine.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Cell Differentiation; Cell Line; Deoxyadenosines; Dimethyl Sulfoxide; DNA; Leukemia, Erythroblastic, Acute; Methylation; Mice; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides; Tubercidin | 1985 |
Inhibition of macrophage phagocytosis by methylation inhibitors. Lack of correlation of protein carboxymethylation and phospholipid methylation with phagocytosis.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Cells, Cultured; Deoxyadenosines; Homocysteine; Kinetics; Macrophages; Methylation; Mice; Phagocytosis; Phospholipids; Proteins; Vidarabine | 1985 |
Early stimulation of phospholipid methylation in Xenopus oocytes by progesterone.
Topics: Adenosine; Animals; Calcium; Deoxyadenosines; Female; Meiosis; Methylation; Methyltransferases; Oocytes; Phospholipids; Progesterone; Thionucleosides; Tubercidin; Xenopus laevis | 1985 |
Inhibition of antibody production by 2-chloroadenosine.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Antibody Formation; B-Lymphocytes; Cells, Cultured; DNA Replication; Homocysteine; Immunosuppressive Agents; Lymphocyte Activation; Male; Methylation; Mice; S-Adenosylmethionine | 1985 |
Effects of sinefungin on rRNA production and methylation in the yeast Saccharomyces cerevisiae.
Topics: Adenosine; Cell Division; Methionine; Methylation; RNA, Ribosomal; Saccharomyces cerevisiae; Uracil | 1985 |
Effect of allylamine antimycotic agents on fungal sterol biosynthesis measured by sterol side-chain methylation.
Topics: Adenosine; Allylamine; Amines; Antifungal Agents; Candida; Candida albicans; Culture Media; Ergosterol; Hydrogen-Ion Concentration; Methionine; Methylation; Naphthalenes; Terbinafine; Trichophyton | 1985 |
Purification and characterization of some metabolic effects of S-neplanocylmethionine.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Escherichia coli; Kinetics; L Cells; Male; Methionine; Methylation; Methyltransferases; Mice; Rats; S-Adenosylmethionine; Substrate Specificity | 1985 |
Differential regulation of polyamine synthesis and transmethylation reactions in methylthioadenosine phosphorylase deficient mammalian cells.
Topics: Adenosine; Animals; B-Lymphocytes; Cell Division; Cell Line; Deoxyadenosines; Fibroblasts; Homocysteine; Humans; Kinetics; Methylation; Mice; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; S-Adenosylhomocysteine; T-Lymphocytes; Thionucleosides | 1985 |
Neplanocin A. Actions on S-adenosylhomocysteine hydrolase and on hormone synthesis by GH4C1 cells.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antibiotics, Antineoplastic; Cell Line; DNA, Neoplasm; Growth Hormone; Hydrolases; Kinetics; Methylation; NAD; Oxidation-Reduction; Pituitary Neoplasms; Prolactin; Rats; RNA, Messenger | 1986 |
2-Chloroadenosine: a selective lethal effect to mouse macrophages and its mechanism.
Topics: 2-Chloroadenosine; Adenosine; Adenosine Triphosphate; Animals; Ascitic Fluid; Cell Line; Cell Membrane; Cell Survival; Coformycin; Female; Iodoacetates; Iodoacetic Acid; Kinetics; Macrophages; Methylation; Mice; Purine Nucleosides | 1985 |
Transient methylation of dolichyl oligosaccharides is an obligatory step in halobacterial sulfated glycoprotein biosynthesis.
Topics: 3-O-Methylglucose; Adenosine; Bacterial Proteins; Clusterin; Glycoproteins; Halobacterium; Homocysteine; Methylation; Methylglucosides; Molecular Chaperones; Polyisoprenyl Phosphate Oligosaccharides; Polyisoprenyl Phosphate Sugars | 1985 |
An early effect of the S component of staphylococcal leukocidin on methylation of phospholipid in various leukocytes.
Topics: Adenine; Adenosine; Animals; Cell Survival; Enzyme Activation; Homocysteine; Leukocidins; Membrane Lipids; Methylation; Neutrophils; Phospholipases A; Phospholipases A2; Phospholipids; Rabbits; Staphylococcus | 1985 |
Methylation of myelin basic protein by enzymes from rat brain.
Topics: Adenosine; Aging; Animals; Arginine; Brain; Carbon Radioisotopes; Cell Nucleus; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Cytoplasm; Homocysteine; Methylation; Methyltransferases; Microsomes; Mitochondria; Myelin Basic Protein; Myelin Sheath; Rats; Ribosomes; S-Adenosylmethionine; Time Factors; Tritium; Ultrafiltration | 1974 |
The occurrence of ribothymidine, 1-methyladenosine, methylated guanosines and the corresponding methyltransferases in E. coli and Bacillus subtilis.
Topics: Adenosine; Autoradiography; Bacillus subtilis; Base Sequence; Carbon Radioisotopes; Culture Media; Escherichia coli; Guanosine; Methylation; Methyltransferases; RNA, Bacterial; RNA, Transfer; Thymidine | 1973 |
Selective binding of barbital to the adenine moieties of FAD and NAD.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Barbiturates; Chemical Phenomena; Chemistry; Deuterium; Dimethyl Sulfoxide; Flavin-Adenine Dinucleotide; Fluorometry; Infrared Rays; Magnetic Resonance Spectroscopy; Methylation; Models, Chemical; NAD; Optical Rotatory Dispersion; Phenobarbital; Spectrophotometry; Ultraviolet Rays | 1970 |
Competing methyltransferase systems.
Topics: Adenosine; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Cell Nucleus; Cytoplasm; Glycine; Homocysteine; Kidney; Liver; Liver Neoplasms; Methylation; Methyltransferases; Mice; Molecular Weight; Pancreas; Rabbits; Rats; RNA, Bacterial; RNA, Transfer; S-Adenosylmethionine | 1972 |
Studies on (8-14C) adenosine-5'-carboxylic acid ethyl ester. II. Incorporation of radioactivity into nucleic acids of mouse and dog.
Topics: Adenosine; Animals; Carbon Radioisotopes; Carboxylic Acids; Chromatography; Chromatography, Ion Exchange; Deoxyribonucleases; DNA; Dogs; Humans; Male; Methylation; Mice; Phosphoric Diester Hydrolases; Ribonucleases; RNA; RNA, Ribosomal; Serum Albumin; Silicon Dioxide; Venoms | 1973 |
Effects of carcinogens and other agents on histone methylation by a histone arginine methyltransferase purified from rat liver cytoplasm.
Topics: Acridines; Adenine; Adenosine; Animals; Arginine; Azo Compounds; Carbon Radioisotopes; Carcinogens; Cytoplasm; Dimethylformamide; Ethidium; Ethionine; Fluorenes; Histones; Homocysteine; Liver; Male; Mesylates; Methylation; Methyltransferases; Nitrosamines; Nitrosoguanidines; Nitrosourea Compounds; Pyrimidines; Pyrroles; Rats; Ribonucleosides; S-Adenosylmethionine | 1974 |
Effects of carcinogens and other agents on histone methylation in rat liver nuclei by endogenous histone lysine methyltransferase.
Topics: Adenosine; Animals; Azo Compounds; Benz(a)Anthracenes; Carbon Radioisotopes; Carcinogens; Cell Nucleus; Dimethylformamide; Ethionine; Fluorenes; Histones; Homocysteine; Liver; Lysine; Mesylates; Methylation; Methyltransferases; Nitrosamines; Nitrosoguanidines; Nitrosourea Compounds; Pyrimidines; Pyrroles; Rats; Ribonucleosides; S-Adenosylmethionine | 1974 |
Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells.
Topics: Adenosine; Carcinoma, Hepatocellular; Cell Fractionation; Cell Line; Cellulose; Chromatography; Cytidine; Guanosine; Liver Neoplasms; Methylation; Neoplasms, Experimental; Nucleosides; Oligonucleotides; Polyribosomes; RNA, Messenger; RNA, Neoplasm; Thymine Nucleotides | 1974 |
Reaction of methyl methanesulphonate with nucleic acids of fetal and newborn rats in vivo.
Topics: Adenine; Adenosine; Animals; Animals, Newborn; Autoradiography; Carbon Radioisotopes; Cytidine; DNA; Female; Fetus; Gestational Age; Guanine; Guanosine; Hydrolysis; Injections, Intraperitoneal; Maternal-Fetal Exchange; Mesylates; Methylation; Nucleic Acids; Pregnancy; Rats; Rats, Inbred Strains; RNA; Time Factors | 1974 |
Biosynthesis of methylheptadecanes in Anabaena variabilis. In vitro incorporation of S-(methyl- 14 C)adenosylmethionine.
Topics: Adenosine; Alkanes; Bile Acids and Salts; Carbon Isotopes; Cariostatic Agents; Chromatography; Chromatography, Gas; Copper; Cyanobacteria; Dithiothreitol; Edetic Acid; Hydrogen-Ion Concentration; Kinetics; Methylation; Muramidase; NADP; Pyridinium Compounds; S-Adenosylmethionine; Sodium Dodecyl Sulfate; Surface-Active Agents; Vibration; Zinc | 1972 |
Methyldeficient mammalian 4s RNA: evidence for L-ethionine-induced inhibition of N6-dimethyladenosine synthesis in rat liver tRNA.
Topics: Adenosine; Animals; Base Sequence; Carbon Radioisotopes; Chromatography, Paper; Chromatography, Thin Layer; Ethionine; Female; Isomerism; Liver; Mass Spectrometry; Methanol; Methylation; Oligonucleotides; Rats; Ribonucleases; RNA, Transfer; Spectrophotometry, Ultraviolet; Time Factors; Transcription, Genetic | 1974 |
Ribosomal RNA turnover in contact inhibited cells.
Topics: Adenosine; Animals; Arginine; Autoradiography; Cells, Cultured; Chick Embryo; Contact Inhibition; Electrophoresis; Fibroblasts; Guanosine; Kinetics; Methionine; Methylation; Phosphates; Phosphorus Isotopes; RNA; RNA, Ribosomal; Thymidine; Tritium; Uridine | 1972 |
[Significance of transmethylation and S-adenosylmethionine (SAM) in the management of Parkinson's disease with L-dopa].
Topics: Adenosine; Aged; Brain; Digestive System; Dihydroxyphenylalanine; Feeding and Eating Disorders; Female; Gastrointestinal Diseases; Humans; Injections, Intramuscular; Injections, Intravenous; Kidney; Male; Methionine; Methylation; Nausea; Parkinson Disease; S-Adenosylmethionine; Vomiting | 1972 |
A fluorescent nucleoside from glutamic acid tRNA of Escherichia coli K 12.
Topics: Adenosine; Base Sequence; Chromatography, DEAE-Cellulose; Escherichia coli; Fluorescence; Glutamates; Methylamines; Methylation; Models, Chemical; Nucleosides; Nucleotides; Pancreas; Pyrimidines; Ribonucleases; RNA, Transfer; Spectrophotometry; Thiouridine; Ultraviolet Rays | 1972 |
Isolation and characterization of 2-methyladenosine from Escherichia coli tRNA Glu 2 , tRNA Asp 1 , tRNA His 1 and tRNA Arg .
Topics: Adenosine; Adenosine Monophosphate; Alkaline Phosphatase; Arginine; Aspartic Acid; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Chromatography, Paper; Chromatography, Thin Layer; Escherichia coli; Glutamates; Histidine; Hydrolysis; Methylation; Ribonucleases; RNA, Bacterial; RNA, Transfer; Spectrophotometry; Ultraviolet Rays | 1972 |
Inhibition of transfer ribonucleic acid methylating enzymes by cytotoxic analogs of adenosine.
Topics: Adenosine; Animals; Antineoplastic Agents; Aza Compounds; Cattle; Chlorine; Escherichia coli; Methylation; Methyltransferases; Purines; RNA, Bacterial; RNA, Transfer; Spleen | 1973 |
Studies on synthetic inhibitors of t-RNA methyl transferases: analogs of S-adenosyl homocysteine.
Topics: Adenosine; Animals; Cysteamine; Cysteine; Escherichia coli; Homocysteine; Kinetics; Liver; Methylation; Propionates; Propylene Glycols; Rabbits; RNA, Transfer; tRNA Methyltransferases | 1973 |
Modified nucleosides in undermethylated phenylalanine transfer RNA from Escherichia coli.
Topics: Adenosine; Amino Acyl-tRNA Synthetases; Borohydrides; Carbon Radioisotopes; Chromatography, DEAE-Cellulose; Chromatography, Ion Exchange; Escherichia coli; Methylation; Methyltransferases; Phenylalanine; Ribonucleosides; RNA, Bacterial; RNA, Transfer; S-Adenosylmethionine; Spectrophotometry, Ultraviolet; Sulfides; Tritium | 1974 |
Enzymatic methylations: III. Cadaverine-induced conformational changes of E. coli tRNA fMet as evidenced by the availability of a specific adenosine and a specific cytidine residue for methylation.
Topics: Adenosine; Animals; Cadaverine; Cytidine; Diamines; Escherichia coli; Hot Temperature; Liver; Magnesium; Methylation; Nucleic Acid Conformation; Nucleic Acid Denaturation; Rats; RNA, Bacterial; RNA, Transfer; tRNA Methyltransferases | 1974 |
[Research on the enzymatic transmethylation of norepinephrine in the axillary bodies of the small dogfish (Scyliorhinus canicula). II. Physicochemical properties of the methylation system].
Topics: Adenosine; Adenosine Triphosphate; Animals; Carbon Isotopes; Chemical Phenomena; Chemistry, Physical; Fishes; Hydrogen-Ion Concentration; Methionine; Methylation; Norepinephrine; Temperature; Time Factors | 1972 |
Interaction of polynucleotides: a hypothesis on reasons for the changes in the ultraviolet spectrum upon complex formation.
Topics: Adenine Nucleotides; Adenosine; Amines; Cytosine Nucleotides; Hydrogen-Ion Concentration; Inosine Nucleotides; Macromolecular Substances; Methylation; Nucleic Acid Conformation; Poly U; Polynucleotides; Purines; Ribonucleosides; Spectrophotometry, Ultraviolet; Uridine | 1972 |
Studies on S-adenosylhomocysteine inhibition of histamine transmethylation in brain.
Topics: Adenosine; Animals; Brain; Brain Chemistry; Carbon Isotopes; Fluorometry; Guinea Pigs; Histamine; Homocysteine; Hot Temperature; Kinetics; Methylation; Methyltransferases; Protein Denaturation; Proteins; Pyrogallol; Time Factors; Tritium | 1973 |
Analysis of the methylation sites in yeast ribosomal RNA.
Topics: Adenosine; Base Sequence; Carbon Radioisotopes; Cellulose; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Paper; Cytidine; Drug Stability; Electrophoresis; Guanosine; Hydrogen-Ion Concentration; Methionine; Methylation; Molecular Weight; Oligonucleotides; Phosphorus Radioisotopes; Ribonucleases; Ribonucleotides; RNA, Ribosomal; Saccharomyces; Uridine | 1973 |
Phototransformation of 4-thiouridine in Escherichia coli valine transfer ribonucleic acid to uridine, cytidine, and N 4 -methylcytidine.
Topics: Adenosine; Alkaline Phosphatase; Amino Acyl-tRNA Synthetases; Ammonia; Binding Sites; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Cytidine; Escherichia coli; Kinetics; Mathematics; Methylamines; Methylation; Photolysis; Quaternary Ammonium Compounds; Radiation Effects; Ribonucleosides; RNA, Bacterial; RNA, Transfer; Spectrophotometry; Thiouracil; Tritium; Ultraviolet Rays; Uridine; Valine | 1971 |
A procedure for the isolation of mammalian messenger ribonucleic acid.
Topics: Adenine Nucleotides; Adenosine; Albumins; Animals; Centrifugation, Zonal; Dactinomycin; Detergents; Hydrogen-Ion Concentration; Methylation; Mice; Micropore Filters; Osmolar Concentration; Phenols; Polynucleotides; Rabbits; Reticulocytes; Ribosomes; RNA, Messenger; Sarcoma 180; Solubility; Sulfuric Acids; Tritium; Uridine | 1972 |
Analogs of S-adenosylhomocysteine as potential inhibitors of biological transmethylation. Synthesis and biological activity of homocysteine derivatives bridged to adenine.
Topics: Adenine; Adenosine; Catechol O-Methyltransferase Inhibitors; Chromatography, Ion Exchange; Chromatography, Thin Layer; Homocysteine; Methylation; Spectrum Analysis; Structure-Activity Relationship; Ultraviolet Rays | 1972 |
[Various effects of SAM dependent transmethylations in hepatology].
Topics: Adenosine; Biopsy; Chronic Disease; Fatty Liver; Hepatitis; Humans; Injections, Intraperitoneal; Lipid Metabolism; Liver Cirrhosis; Liver Diseases; Liver Glycogen; Methionine; Methylation; S-Adenosylmethionine | 1972 |
Kinetics of adenosine uptake by erythrocytes, and the influence of dipyridamole.
Topics: Adenosine; Animals; Carbon Isotopes; Depression, Chemical; Diffusion; Dipyridamole; Erythrocytes; Guinea Pigs; Inosine; Kinetics; Mathematics; Methylation; Models, Biological; Octanols; Osmolar Concentration | 1972 |
Inhibition of catechol-O-methyltransferase by S-adenosylhomocysteine and S-adenosylhomocysteine sulfoxide, a potential transition-state analog.
Topics: Adenosine; Animals; Carbon Isotopes; Catechol O-Methyltransferase Inhibitors; Chemical Phenomena; Chemistry; Homocysteine; Kinetics; Liver; Methylation; Methyltransferases; Rats; Structure-Activity Relationship; Sulfoxides | 1972 |
N 6 -( 2 -isopentenyl)adenosine metabolism in man.
Topics: Adenosine; Alkenes; Amino Alcohols; Animals; Carbon Isotopes; Chromatography; Chromatography, Ion Exchange; Chromatography, Paper; Humans; Hypoxanthines; Methylation; Milk; Models, Biological; Models, Chemical; Peroxidases; Spectrophotometry; Ultraviolet Rays; Uric Acid; Xanthine Oxidase; Xanthines | 1972 |
NMR studies of organic solvent denatured yeast phenylalanyl transfer RNA at 220 MHZ a.
Topics: Adenosine; Carbon Isotopes; Chromatography, Ion Exchange; Computers; Cytidine; Deuterium; Dimethyl Sulfoxide; Guanosine; Lithium; Magnetic Resonance Spectroscopy; Methylation; Nucleic Acid Denaturation; Phenylalanine; Pyrimidines; RNA, Transfer; Thymidine; Yeasts | 1971 |
Reaction of 7-bromomethylbenz(a)anthracene with nucleic acids, polynucleotides, and nucleosides.
Topics: Adenosine; Amines; Benz(a)Anthracenes; Bromine; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Thin Layer; Cytidine; Guanosine; Methylation; Nucleic Acids; Nucleosides; Polynucleotides; Pyridinium Compounds; Spectrum Analysis; Tosyl Compounds; Tritium; Ultraviolet Rays | 1971 |
Mass spectra of some heterocycles related to N 6 -( 2 -isopentenyl)adenosine.
Topics: Adenine; Adenosine; Alkenes; Mass Spectrometry; Methylation; Nucleosides; Pyrazoles; Pyrimidines; Pyrroles; Sulfides | 1971 |
Nucleic acid related compounds. II. A rapid and quantitative preparation of 2'-0- and 3'-0-methyl nucleosides.
Topics: Adenosine; Chemical Phenomena; Chemistry; Chlorides; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cytidine; Diazomethane; Ethers; Methods; Methylation; Nucleosides; Ribonucleosides; Tin | 1971 |
Effect of 5'-methylthioadenosine, 3-deazaadenosine, and related compounds on human natural killer cell activity. Relation to cyclic AMP and methylation potential.
Topics: Adenosine; Cyclic AMP; Cytotoxicity, Immunologic; Deoxyadenosines; Humans; Killer Cells, Natural; Lymphocytes; Methylation; Ribonucleosides; Thionucleosides; Tubercidin | 1984 |
Regulation of depolarization-dependent release of neurotransmitters by adenosine: cyclic AMP-dependent enhancement of release from PC12 cells.
Topics: 2-Chloroadenosine; Adenosine; Adenylyl Cyclases; Adrenal Gland Neoplasms; Animals; Cell Line; Cyclic AMP; Deoxyadenosines; Dideoxyadenosine; Methylation; Neurotransmitter Agents; Pheochromocytoma; Phosphatidylethanolamines; Rats | 1983 |
The effect of 5-azacytidine and dihydro-5-azacytidine on nuclear ribosomal RNA and poly(A) RNA synthesis in L1210 cells in vitro.
Topics: Adenosine; Animals; Azacitidine; Cells, Cultured; Depression, Chemical; Dose-Response Relationship, Drug; Leukemia L1210; Methionine; Methylation; Mice; Poly A; RNA; RNA, Heterogeneous Nuclear; RNA, Messenger; RNA, Ribosomal; Uridine | 1980 |
Evidence that the inhibitory effect of adenosine, but not cordycepin, on the methylation of nuclear RNA is mediated by S-adenosylhomocysteine hydrolase.
Topics: Adenosine; Adenosylhomocysteinase; Adult; Animals; Cell Nucleus; Deoxyadenosines; Homocysteine; Humans; Hydrolases; Leukemia L1210; Methylation; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Increased methylation of RNA in SV40-infected interferon-treated cells.
Topics: Adenosine; Animals; Cell Line; Interferons; Methylation; Poly A; Protein Biosynthesis; RNA Caps; RNA, Messenger; RNA, Viral; Simian virus 40 | 1981 |
Effect of inhibitors of transmethylation on histamine release from human basophils.
Topics: Adenine; Adenosine; Basophils; Calcimycin; Histamine Release; Homocysteine; Humans; Immunoglobulin E; In Vitro Techniques; Methylation; Ribonucleosides; S-Adenosylmethionine; Tubercidin | 1981 |
Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation.
Topics: Adenine; Adenosine; Animals; Basophils; Female; Histamine Release; Homocysteine; Immunoglobulin E; Leukemia; Mast Cells; Methylation; Mice; Rabbits; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1981 |
Effect of inhibitors of methylation on early and late interferon synthesis in bovine kidney cell cultures.
Topics: Adenine; Adenosine; Animals; Cattle; Cells, Cultured; Cycloheximide; Cycloleucine; Homocysteine; Interferons; Methylation; Newcastle disease virus; Poly I-C; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Effect of several inhibitors of enzymatic DNA methylation on the in vivo methylation of different classes of DNA sequences in a cultured human cell line.
Topics: 5-Methylcytosine; Adenosine; Azacitidine; Brain Neoplasms; Cell Division; Cell Line; Cycloleucine; Cytosine; Deoxyadenosines; DNA; DNA Replication; Ethionine; Homocysteine; Humans; Methylation; Thionucleosides; Tubercidin | 1983 |
The effect of methyltransferase inhibitors on histamine release from human dispersed lung mast cells activated with anti-human IgE and calcium ionophore A23187.
Topics: Adenine; Adenosine; Antibodies, Anti-Idiotypic; Calcimycin; Histamine Release; Humans; Immunoglobulin E; Mast Cells; Membrane Lipids; Methylation; Methyltransferases; Phospholipids; Ribonucleosides; S-Adenosylmethionine; Tubercidin | 1984 |
Comparative effect of S-adenosyl-homocysteine (SAH) and Sinefungin on tRNA-base methylation in whole cells and in vitro.
Topics: Adenine; Adenosine; Animals; Antifungal Agents; Avian Sarcoma Viruses; Cell Transformation, Viral; Escherichia coli; Guanine; Homocysteine; Methylation; RNA, Transfer; S-Adenosylhomocysteine | 1981 |
Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages.
Topics: Adenosine; Animals; Arachidonic Acid; Arachidonic Acids; Cell Membrane; Cells, Cultured; Chemotactic Factors; Chemotaxis, Leukocyte; Guinea Pigs; Homocysteine; Isoproterenol; Kinetics; Methylation; Receptors, Cell Surface; Receptors, Formyl Peptide; S-Adenosylmethionine; Superoxides; Theophylline | 1982 |
Role of transmethylation in the elicitation of an oxidative burst in macrophages.
Topics: Adenosine; Animals; Concanavalin A; Depression, Chemical; Guinea Pigs; Homocysteine; Lectins; Macrophage Activation; Macrophages; Methylation; N-Formylmethionine; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Oxygen; Superoxides; Tubercidin; Wheat Germ Agglutinins | 1982 |
Adenosine: a physiological modulator of superoxide anion generation by human neutrophils.
Topics: 2-Chloroadenosine; Adenine; Adenosine; Adenosine Deaminase; Calcimycin; Cell Aggregation; Coformycin; Cytochalasin B; Cytoplasmic Granules; Depression, Chemical; Dipyridamole; Humans; Methylation; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pentostatin; Superoxides | 1983 |
Methylations of adenosine residues (m6A) in pre-mRNA are important for formation of late simian virus 40 mRNAs.
Topics: Adenosine; Animals; Cell Transformation, Viral; Cycloleucine; Methionine Adenosyltransferase; Methylation; Nucleic Acid Precursors; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Viral; Simian virus 40; Transcription, Genetic | 1983 |
Fast atom bombardment combined with tandem mass spectrometry for the determination of nucleosides.
Topics: Adenosine; Chemical Phenomena; Chemistry; Computers; Isomerism; Mass Spectrometry; Methylation; Noble Gases; Nucleosides; Nucleotides; Purine Nucleosides; Ribonucleosides; Tubercidin | 1984 |
Neplanocin A. A cyclopentenyl analog of adenosine with specificity for inhibiting RNA methylation.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Antibiotics, Antineoplastic; Cell Line; Cell Survival; Coformycin; Colonic Neoplasms; DNA Replication; Humans; Kinetics; Methylation; Pentostatin; Protein Biosynthesis; Ribonucleosides; RNA, Ribosomal; Transcription, Genetic | 1984 |
Calorimetric measurements of the destabilisation of a ribosomal RNA hairpin by dimethylation of two adjacent adenosines.
Topics: Adenosine; Base Sequence; Calorimetry; Drug Stability; Escherichia coli; Geobacillus stearothermophilus; Methylation; Nucleic Acid Conformation; RNA, Ribosomal | 1983 |
The mechanism of cell-mediated cytotoxicity. III. Protease-specific inhibitors preferentially block later events in cytotoxic T lymphocyte-mediated lysis than do inhibitors of methylation or thiol-reactive agents.
Topics: Adenosine; alpha 1-Antichymotrypsin; Animals; Bridged Bicyclo Compounds; Calcium; Chymotrypsin; Coformycin; Cytotoxicity, Immunologic; Deoxyadenosines; Methylation; Mice; Mice, Inbred Strains; Pentostatin; Peptide Hydrolases; Sulfhydryl Compounds; T-Lymphocytes, Cytotoxic; Time Factors; Tyrosine | 1983 |
Partial methylation of two adjacent adenosines in ribosomes from Euglena gracilis chloroplasts suggests evolutionary loss of an intermediate stage in the methyl-transfer reaction.
Topics: Adenine; Adenosine; Biological Evolution; Chloroplasts; Cloacin; Escherichia coli; Euglena gracilis; Methylation; Methyltransferases; Ribosomes; RNA Processing, Post-Transcriptional; RNA, Ribosomal | 1984 |
Fibronectin-induced protein carboxy-O-methylation in aortic endothelial cells.
Topics: Adenosine; Animals; Aorta; Cattle; Cells, Cultured; Chemotaxis; Endothelium; Fibronectins; Kinetics; Methylation; Protein Methyltransferases; Protein O-Methyltransferase; Proteins; S-Adenosylmethionine; Toyocamycin | 1984 |
Brain methylation and epileptogenesis: the case of methionine sulfoximine.
Topics: Adenosine; Animals; Brain; Epilepsy; Histamine; Homocysteine; Methionine; Methionine Sulfoximine; Methylation; Methylhistamines; Mice; Nerve Tissue Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
Correlations between phospholipid methylation and neuronal catecholamine transport.
Topics: Adenine; Adenosine; Animals; Biological Transport; Cerebral Cortex; Cytosol; Homocysteine; Kinetics; Male; Membrane Lipids; Methylation; Norepinephrine; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats; Rats, Inbred Strains; S-Adenosylhomocysteine; Synaptosomes | 1984 |
Inhibition of protein carboxyl methylation by S-adenosyl-L-homocysteine in intact erythrocytes. Physiological consequences.
Topics: Adenosine; Aspartic Acid; Erythrocyte Membrane; Erythrocytes; Homocysteine; Humans; Membrane Proteins; Methionine; Methylation; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine | 1984 |
2'-O-methyl-1-methyl adenosine: a new modified nucleoside in ragi (Eleusine coracana) tRNA.
Topics: Adenosine; Autoradiography; Base Sequence; Chemical Phenomena; Chemistry; Methylation; RNA, Transfer; Seeds | 1984 |
Conformations of 3-methylpurine nucleosides: implications on the structure of DNA duplexes.
Topics: Adenosine; DNA; Methylation; Nucleic Acid Conformation; Purine Nucleosides | 1984 |
Possible role of increased brain methylation in methionine sulfoximine epileptogenesis: effects of administration of adenosine and homocysteine thiolactone.
Topics: Adenosine; Animals; Brain; Brain Chemistry; Histamine; Homocysteine; Methionine Sulfoximine; Methylation; Mice; Mice, Inbred Strains; Nerve Tissue Proteins; Phospholipids; Reaction Time; Seizures | 1983 |
Effects of adenosine dialdehyde on S-adenosylhomocysteine hydrolase and S-adenosylmethionine-dependent transmethylations in mouse L929 cells.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Hydrolases; Kinetics; L Cells; Methylation; Methyltransferases; Mice; S-Adenosylmethionine | 1984 |
Hypomethylation of DNA in ethionine-fed rats.
Topics: Adenosine; Animals; Deoxycytidine; DNA; Ethionine; Gene Expression Regulation; Liver; Male; Methylation; Rats; Rats, Inbred F344; S-Adenosylmethionine; Time Factors | 1984 |
Transmethylation reactions are required for initial morphologic and biochemical responses of human monocytes to chemoattractants.
Topics: Adenine; Adenosine; Arachidonic Acid; Arachidonic Acids; Chemical Phenomena; Chemistry; Chemoreceptor Cells; Chemotaxis, Leukocyte; Homocysteine; Humans; Kinetics; Lipid Metabolism; Methylation; Monocytes | 1981 |
Perturbations in S-adenosylhomocysteine and S-adenosylmethionine metabolism: effects on transmethylation.
Topics: Adenosine; Adenosylhomocysteinase; Cell Line; Deoxyadenosines; Homocysteine; Humans; Hydrolases; Lymphocytes; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Spleen | 1980 |
Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16S ribosomal RNA of Escherichia coli. IV. The effect of the methylgroups on ribosomal subunit interaction.
Topics: Adenosine; Cloacin; Escherichia coli; Kinetics; Methylation; Mutation; Ribosomes; RNA, Ribosomal; Structure-Activity Relationship | 1980 |
Inhibition of sterol transmethylation by S-adenosylhomocysteine analogs.
Topics: Adenosine; Ergosterol; Methylation; Methyltransferases; S-Adenosylmethionine; Saccharomyces cerevisiae; Sterols; Structure-Activity Relationship | 1981 |
Adenosine dimethylation of 16S ribosomal RNA: effect of the methylgroups on local conformational stability as deduced from electrophoretic mobility of RNA fragments in denaturing polyacrylamide gels.
Topics: Adenosine; Base Composition; Base Sequence; Cloacin; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Methylation; Molecular Weight; Nucleic Acid Conformation; Nucleic Acid Denaturation; RNA, Ribosomal | 1981 |
Destabilization of secondary structure in 16S ribosomal RNA by dimethylation of two adjacent adenosines.
Topics: Adenosine; Chemical Phenomena; Chemistry, Physical; Escherichia coli; Methylation; Nucleic Acid Conformation; RNA, Ribosomal; Spectrophotometry, Ultraviolet | 1981 |
The effect of pharmacologic inhibition of phospholipid methylation on human platelet function.
Topics: Adenosine; Adenosylhomocysteinase; Blood Platelets; Humans; Hydrolases; Methylation; Phosphatidylethanolamines; Phospholipids; Platelet Aggregation; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1982 |
Effects of 8-azaadenosine and formycin on cell lethality and the synthesis and methylation of nucleic acids in human colon carcinoma cells in culture.
Topics: Adenosine; Antibiotics, Antineoplastic; Cell Survival; Cells, Cultured; Colonic Neoplasms; DNA, Neoplasm; Formycins; Humans; Methylation; Neoplasms, Experimental; RNA, Neoplasm | 1982 |
Inhibition of phospholipid methylation in isolated rat hepatocytes by analogues of adenosine and S-adenosylhomocysteine.
Topics: Adenosine; Animals; Homocysteine; In Vitro Techniques; Liver; Methylation; Methyltransferases; Phosphatidylethanolamine N-Methyltransferase; Phospholipids; Rats; S-Adenosylhomocysteine | 1982 |
Role of transmethylation reactions in cellular motility and phagocytosis.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adult; Animals; Cell Movement; Chemotaxis, Leukocyte; Depression, Chemical; Guinea Pigs; Humans; In Vitro Techniques; Lactones; Macrophages; Methylation; Models, Biological; Monocytes; Peptides; Phagocytosis; Phospholipids; S-Adenosylhomocysteine; S-Adenosylmethionine | 1980 |
Decreased in vivo protein and phospholipid methylation after in vivo elevation of brain S-adenosyl-homocysteine.
Topics: Adenosine; Animals; Brain; Homocysteine; Male; Methylation; Mice; Nerve Tissue Proteins; Phospholipids; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
Effect of 5'-methylthioadenosine on in vivo methyl esterification of human erythrocyte membrane proteins.
Topics: Adenine; Adenosine; Deoxyadenosines; Erythrocyte Membrane; Erythrocytes; Humans; Membrane Proteins; Methylation; Protein Methyltransferases; Protein O-Methyltransferase; Thionucleosides | 1981 |
Decreased transmethylation of biogenic amines after in vivo elevation of brain S-adenosyl-l-homocysteine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Biogenic Amines; Brain; Catechol O-Methyltransferase Inhibitors; Histamine; Histamine N-Methyltransferase; Homocysteine; Hydrolases; Liver; Male; Methylation; Mice; S-Adenosylhomocysteine; S-Adenosylmethionine | 1981 |
[Possible regulatory role of 5'-methylthioadenosine on enzymatic methyl esterification of membrane protein].
Topics: Adenine; Adenosine; Deoxyadenosines; Erythrocytes; Humans; Membrane Proteins; Methylation; Protein O-Methyltransferase; S-Adenosylmethionine; Thionucleosides | 1981 |
Effect of sangivamycin and xylosyladenine on the synthesis and methylation of polysomal ribonucleic acid in Ehrlich ascites cells in vitro.
Topics: Adenosine; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Methylation; Mice; Pyrimidine Nucleosides; RNA, Neoplasm | 1981 |
Induction of hemoglobin synthesis by xylosyladenine in murine erythroleukemia cells. Metabolism of xylosyladenine and effects on transmethylation.
Topics: Adenosine; Animals; Cell Division; Dimethyl Sulfoxide; Hemoglobins; Kinetics; Leukemia, Experimental; Methionine Adenosyltransferase; Methylation; Mice | 1981 |
A simple method of the preparation of 2'-O-methyladenosine. Methylation of adenosine with methyl iodide in anhydrous alkaline medium.
Topics: Adenosine; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Crystallization; Hydrogen-Ion Concentration; Iodides; Magnetic Resonance Spectroscopy; Methylation; Spectrophotometry, Ultraviolet | 1980 |
Characterization of adenosine-induced cytostasis in melanoma cells.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Animals; Cell Count; Cell Division; Cell Line; Guanosine; Homocysteine; Melanoma; Methylation; Mice; Neoplasms, Experimental; Pyrimidines; RNA, Neoplasm; Uridine | 1980 |
The effect of 5-fluorouracil on the synthesis and methylation of low molecular weight nuclear RNA in L1210 cells.
Topics: Adenosine; Animals; Cell Nucleus; Cells, Cultured; Dose-Response Relationship, Drug; Fluorouracil; Leukemia L1210; Methylation; Mice; Molecular Weight; RNA, Neoplasm; Time Factors | 1980 |
Inhibition of methylation of nuclear ribonucleic acid in L1210 cells by tubercidin, 8-azaadenosine and formycin.
Topics: Adenosine; Animals; Antineoplastic Agents; Cell Nucleus; Cells, Cultured; DNA, Neoplasm; Formycins; Leukemia L1210; Methylation; Mice; RNA, Neoplasm; Tubercidin | 1980 |
The rate of transmethylation in mouse liver as measured by trapping S-adenosylhomocysteine.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Homocysteine; Hydrolases; Liver; Methylation; Mice; S-Adenosylhomocysteine | 1980 |
Accurate and efficient N-6-adenosine methylation in spliceosomal U6 small nuclear RNA by HeLa cell extract in vitro.
Topics: Adenosine; Base Sequence; Cell Nucleus; HeLa Cells; Humans; Kinetics; Methylation; Methyltransferases; Molecular Sequence Data; Nucleic Acid Conformation; Prolactin; RNA, Messenger; RNA, Small Nuclear; Spliceosomes; Substrate Specificity | 1995 |
Sequence-specific binding of DNA by the EcoRV restriction and modification enzymes with nucleic acid and cofactor analogues.
Topics: Adenosine; Base Sequence; Binding Sites; Chromatography, High Pressure Liquid; DNA; Escherichia coli; Magnesium; Methylation; Molecular Sequence Data; Oligodeoxyribonucleotides; S-Adenosylmethionine; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 1995 |
Probing the protein-DNA interface of the EcoRV modification methyltransferase bound to its recognition sequence, GATATC.
Topics: Adenosine; Base Sequence; Binding Sites; Computer Graphics; DNA; Escherichia coli; Ethylnitrosourea; Exodeoxyribonucleases; Methylation; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Phosphates; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 1995 |
3-deaza- and 7-deaza-5'-noraristeromycin and their antiviral properties.
Topics: Adenosine; Animals; Antiviral Agents; Cattle; Cell Division; Cells, Cultured; Chlorocebus aethiops; HeLa Cells; HIV-1; HIV-2; Humans; Leukemia L1210; Male; Methylation; Mice; Microbial Sensitivity Tests; T-Lymphocytes; Vero Cells | 1995 |
Mechanism of erythrocyte accumulation of methylation inhibitor S-adenosylhomocysteine in uremia.
Topics: Adenosine; Adenosylhomocysteinase; Adult; Aspartate Aminotransferases; Erythrocytes; Female; Homocysteine; Humans; Hydrolases; Male; Methylation; Middle Aged; S-Adenosylhomocysteine; S-Adenosylmethionine; Uremia | 1995 |
N6-substituted adenosine receptor agonists. Synthesis and pharmacological activity as potent antinociceptive agents.
Topics: Adenosine; Analgesia; Analgesics; Animals; Indoles; Methylation; Mice; Molecular Structure; Nitrogen; Purinergic P1 Receptor Agonists; Rats; Receptors, Purinergic P1; Structure-Activity Relationship; Theophylline | 1994 |
Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-kappa B in L929 cells.
Topics: Adenosine; Cell Line; Cell Survival; Drug Synergism; Homocysteine; In Vitro Techniques; Methylation; NF-kappa B; Reactive Oxygen Species; S-Adenosylhomocysteine; Tumor Necrosis Factor-alpha | 1994 |
The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast.
Topics: Adenosine; Amino Acid Sequence; Base Sequence; Cloning, Molecular; Fungal Proteins; Genes, Fungal; Genes, Lethal; Methylation; Methyltransferases; Molecular Sequence Data; RNA, Fungal; RNA, Ribosomal, 18S; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Analysis, DNA | 1994 |
Crystal structure of catechol O-methyltransferase.
Topics: Adenosine; Amino Acid Sequence; Animals; Binding Sites; Catechol O-Methyltransferase; Catecholamines; Coenzymes; Consensus Sequence; Crystallography, X-Ray; DNA Modification Methylases; Escherichia coli; Humans; Liver; Methionine; Methylation; Models, Molecular; Rats; Recombinant Proteins; Sequence Homology, Amino Acid | 1994 |
Z-4',5'-didehydro-5'-deoxy-5'-fluoroadenosine (MDL 28,842), an irreversible inhibitor of S-adenosylhomocysteine hydrolase, suppresses proliferation of cultured keratinocytes and squamous carcinoma cell lines.
Topics: Adenosine; Adenosylhomocysteinase; Carcinoma, Squamous Cell; Cell Differentiation; Cell Division; Cells, Cultured; Humans; Hydrolases; Keratinocytes; Methylation; Tumor Cells, Cultured | 1993 |
Identification of active-site cysteines in the conserved domain of PilD, the bifunctional type IV pilin leader peptidase/N-methyltransferase of Pseudomonas aeruginosa.
Topics: Adenosine; Alkylation; Amino Acid Sequence; Bacterial Outer Membrane Proteins; Bacterial Proteins; Binding Sites; Cloning, Molecular; Cysteine; Endopeptidases; Fimbriae Proteins; Methylation; Methyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Protein Processing, Post-Translational; Pseudomonas aeruginosa; Sequence Homology, Amino Acid; Sulfhydryl Reagents | 1993 |
Effects of sinefungin on growth and sterol composition of Leishmania promastigotes.
Topics: Adenosine; Animals; Antiprotozoal Agents; Leishmania; Methylation; Sterols | 1993 |
Adenosine analogs inhibit the guanine-7-methylation of mRNA cap structures.
Topics: Adenosine; Animals; Carcinoma, Ehrlich Tumor; In Vitro Techniques; Methylation; Methyltransferases; Mice; RNA Caps; S-Adenosylhomocysteine | 1993 |
Adenosine stimulation of AMP deaminase activity in adult rat cardiac myocytes.
Topics: Adenosine; Alkaloids; AMP Deaminase; Animals; Inosine Monophosphate; Methylation; Myocardium; Pertussis Toxin; Protein Kinase C; Rats; S-Adenosylhomocysteine; Staurosporine; Sympathomimetics; Virulence Factors, Bordetella | 1993 |
Accumulation of substrates for protein L-isoaspartyl methyltransferase in adenosine dialdehyde-treated PC12 cells.
Topics: Adenosine; Amino Acid Sequence; Animals; Cell Division; Kinetics; Methylation; Molecular Sequence Data; Oxidation-Reduction; PC12 Cells; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Proteins; Substrate Specificity | 1993 |
DNA methylation in mycobacteria: absence of methylation at GATC (Dam) and CCA/TGG (Dcm) sequences.
Topics: 5-Methylcytosine; Adenosine; Base Sequence; Cytosine; Deoxyribonucleases, Type II Site-Specific; DNA (Cytosine-5-)-Methyltransferases; DNA-Cytosine Methylases; DNA, Bacterial; Methylation; Molecular Sequence Data; Mycobacterium; Mycobacterium tuberculosis; Site-Specific DNA-Methyltransferase (Adenine-Specific); Species Specificity; Substrate Specificity; Virulence | 1995 |
Crithidia luciliae: effect of purine starvation on S-adenosyl-L-methionine uptake and protein methylation.
Topics: Adenosine; Animals; Crithidia; Cycloheximide; Decarboxylation; Methionine; Methylation; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Purines; S-Adenosylhomocysteine; S-Adenosylmethionine; Thionucleosides | 1995 |
N6-methyladenosine inhibits murine erythroleukemia cell maturation by blocking methylation of RNA and memory via conversion to S-(N6-methyl)-adenosylhomocysteine.
Topics: Adenosine; Animals; Cell Differentiation; Cell Division; Kinetics; Leukemia, Erythroblastic, Acute; Methylation; Mice; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1995 |
Induction of murine erythroleukemia cell differentiation is associated with methylation and differential stability of poly(A)+ RNA transcripts.
Topics: Actins; Adenosine; Animals; Cell Differentiation; Cell Division; Cycloleucine; Dimethyl Sulfoxide; Erythrocytes; Erythropoiesis; Globins; Hemoglobins; Kinetics; Leukemia, Erythroblastic, Acute; Methylation; Mice; Neoplasm Proteins; Peroxidases; Peroxiredoxin III; Peroxiredoxins; Proto-Oncogene Proteins c-myc; Ribonucleotides; RNA Caps; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Cells, Cultured | 1996 |
Mechanisms of the effects of methotrexate.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Humans; Methotrexate; Methylation; Rheumatoid Nodule | 1996 |
Apoptosis and transmethylation metabolites in HL-60 cells.
Topics: Adenosine; Apoptosis; DNA; DNA Fragmentation; Enzyme Inhibitors; HL-60 Cells; Homocysteine; Humans; Methylation; Methyltransferases; Nucleic Acid Synthesis Inhibitors; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine; Tubercidin | 1996 |
Resistance to inhibitors of S-adenosyl-L-homocysteine hydrolase in C1300 murine neuroblastoma tumor cells is associated with increased methionine adenosyltransferase activity.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Cell Division; Drug Resistance, Neoplasm; Enzyme Inhibitors; Hydrolases; Male; Methionine Adenosyltransferase; Methylation; Mice; Mice, Inbred A; Neuroblastoma; S-Adenosylhomocysteine; S-Adenosylmethionine; Tritium; Tumor Cells, Cultured | 1995 |
Mechanisms of selenium methylation and toxicity in mice treated with selenocystine.
Topics: Adenosine; Animals; Chemical and Drug Induced Liver Injury; Liver; Liver Function Tests; Male; Methionine Adenosyltransferase; Methylation; Methyltransferases; Mice; Mice, Inbred ICR; Selenium; Selenium Compounds; Selenocysteine | 1996 |
Suppression by phenobarbital of ethionine-induced hepatocellular carcinoma formation and hepatic S-adenosylethionine levels.
Topics: Adenosine; Animals; Body Weight; Ethionine; Liver; Liver Neoplasms; Male; Methylation; Organ Size; Phenobarbital; Rats; Rats, Inbred F344; S-Adenosylmethionine | 1997 |
Essential arginine residues in isoprenylcysteine protein carboxyl methyltransferase.
Topics: Adenosine; Animals; Arginine; Cell Membrane; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kidney; Male; Methylation; Phenylglyoxal; Protein Methyltransferases; Rats; Rats, Sprague-Dawley; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 1997 |
Nerve growth factor-specific regulation of protein methylation during neuronal differentiation of PC12 cells.
Topics: Adenosine; Animals; Cell Differentiation; Cell-Free System; DNA Methylation; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Homocysteine; Kinetics; Methionine; Methylation; Nerve Growth Factors; Nerve Tissue Proteins; Neurites; Neurons; PC12 Cells; Protein Processing, Post-Translational; Rats; S-Adenosylmethionine; Signal Transduction; Tritium | 1997 |
Metabolism of exogenous S-adenosylmethionine in isolated rat hepatocyte suspensions: methylation of plasma-membrane phospholipids without intracellular uptake.
Topics: Adenosine; Animals; Cells, Cultured; Humans; Kinetics; Liver; Liver Diseases; Male; Membrane Lipids; Methylation; Phospholipids; Rats; Rats, Wistar; S-Adenosylhomocysteine; S-Adenosylmethionine | 1997 |
Protein N-arginine methylation in adenosine dialdehyde-treated lymphoblastoid cells.
Topics: Adenosine; Amino Acid Sequence; Arginine; Binding, Competitive; Cell Line, Transformed; Enzyme Inhibitors; Glutathione Transferase; Humans; Lymphocytes; Methylation; Molecular Sequence Data; Peptides; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Saccharomyces cerevisiae | 1998 |
The structure of a methylated tetraloop in 16S ribosomal RNA.
Topics: Adenosine; Geobacillus stearothermophilus; Guanosine; Methylation; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Conformation; RNA, Bacterial; RNA, Ribosomal, 16S; Solutions | 1998 |
Two intertwined methylation activities of the MmeI restriction-modification class-IIS system from Methylophilus methylotrophus.
Topics: Adenosine; Deoxyribonucleases, Type II Site-Specific; DNA Methylation; DNA, Bacterial; Gram-Negative Aerobic Bacteria; Methylation; Methyltransferases; S-Adenosylmethionine | 1998 |
An unusual chemical reactivity of Sm site adenosines strongly correlates with proper assembly of core U snRNP particles.
Topics: Adenosine; Animals; Autoantigens; Binding Sites; Cell Nucleus; Methylation; Nucleic Acid Conformation; Oocytes; Ribonucleoprotein, U1 Small Nuclear; Ribonucleoproteins, Small Nuclear; snRNP Core Proteins; Uridine; Xenopus laevis | 1999 |
ErmE methyltransferase recognizes features of the primary and secondary structure in a motif within domain V of 23 S rRNA.
Topics: Adenosine; Anti-Bacterial Agents; Bacterial Proteins; Drug Resistance, Microbial; Escherichia coli; Macrolides; Methylation; Methyltransferases; Nucleic Acid Conformation; Peptide Chain Elongation, Translational; Point Mutation; Ribosomes; RNA, Bacterial; RNA, Ribosomal, 23S; Substrate Specificity | 1999 |
Basis for prokaryotic specificity of action of aminoglycoside antibiotics.
Topics: Adenosine; Amino Acid Substitution; Aminoglycosides; Ampicillin; Anti-Bacterial Agents; Base Sequence; Binding Sites; Drug Resistance, Microbial; Escherichia coli; Eukaryotic Cells; Guanosine; Methylation; Microbial Sensitivity Tests; Ribosomes; RNA, Ribosomal, 16S; Species Specificity; Spectinomycin; Substrate Specificity; Sulfuric Acid Esters | 1999 |
Synthetic substrate analogs for the RNA-editing adenosine deaminase ADAR-2.
Topics: Adenosine; Adenosine Deaminase; Animals; Base Pairing; Base Sequence; Kinetics; Methylation; Molecular Weight; Nucleic Acid Heteroduplexes; Oligoribonucleotides; Rats; Receptors, AMPA; Recombinant Proteins; Regulatory Sequences, Nucleic Acid; Ribose; RNA Editing; RNA Precursors; RNA-Binding Proteins; RNA, Double-Stranded | 1999 |
Negative in vitro selection identifies the rRNA recognition motif for ErmE methyltransferase.
Topics: Adenosine; Base Sequence; Cloning, Molecular; Escherichia coli; Genetic Techniques; Methylation; Methyltransferases; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; RNA, Ribosomal, 23S | 1999 |
The possible role of protein-carboxyl methylation in the regulation of flagellar movement of fowl spermatozoa.
Topics: Adenosine; Adenosine Triphosphate; Animals; Calcium Chloride; Chickens; Enzyme Inhibitors; Homocysteine; Luminescent Measurements; Male; Marine Toxins; Methylation; Oxazoles; Proteins; Semen; Sperm Motility; Sperm Tail; Tubercidin | 2000 |
The RGG domain in hnRNP A2 affects subcellular localization.
Topics: 3T3 Cells; Adenosine; Animals; Cell Line; Cell Nucleus; Cytoplasm; Enzyme Inhibitors; Heterogeneous Nuclear Ribonucleoprotein A1; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Heterogeneous-Nuclear Ribonucleoproteins; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Lymphocytes; Methylation; Methyltransferases; Mice; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; Ribonucleoproteins; Subcellular Fractions | 2000 |
Methyl-deficient mammalian transfer RNA: II. Homologous methylation in vitro of liver tRNA from normal and ethionine-fed rats: ethionine effect on 5-methyl-cytidine synthesis in vivo.
Topics: 5-Methylcytosine; Adenosine; Administration, Oral; Animals; Cadaverine; Cytosine; Ethionine; Liver; Magnesium; Methylation; Nucleic Acid Conformation; Rats; RNA, Transfer; tRNA Methyltransferases | 1974 |
A single adenosine with a neutral pKa in the ribosomal peptidyl transferase center.
Topics: Adenosine; Binding Sites; Catalysis; Dimethyl Sulfoxide; Escherichia coli; Hydrogen Bonding; Methylation; Mutation; Peptide Biosynthesis; Peptidyl Transferases; Protons; Ribosomes; RNA, Bacterial; RNA, Ribosomal, 23S; Tubercidin | 2000 |
Protein N-arginine methylation in subcellular fractions of lymphoblastoid cells.
Topics: Adenosine; Arginine; Blotting, Western; Enzyme Inhibitors; Glutathione Transferase; Humans; Lymphocytes; Methylation; Peptides; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; Subcellular Fractions | 2000 |
A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-L-methionine cycle.
Topics: Adenosine; Adenosylhomocysteinase; Caffeine; Carbon Dioxide; Cell Extracts; Chloroplasts; Homocysteine; Hydrolases; Methionine Adenosyltransferase; Methylation; Plant Leaves; S-Adenosylhomocysteine; S-Adenosylmethionine; Tea; Theobromine | 2001 |
Mutation of the methylated tRNA(Lys)(3) residue A58 disrupts reverse transcription and inhibits replication of human immunodeficiency virus type 1.
Topics: Adenosine; Base Sequence; Cell Line; DNA, Viral; HIV-1; Humans; Methylation; Mutagenesis, Site-Directed; RNA, Transfer, Amino Acyl; T-Lymphocytes; Transcription, Genetic; Transfection; Virus Replication | 2001 |
Methylation of the nucleobases in RNA oligonucleotides mediates duplex-hairpin conversion.
Topics: Adenosine; Base Pairing; Cytidine; Guanosine; Hydrogen Bonding; Inosine; Methylation; Nucleic Acid Conformation; Oligoribonucleotides; RNA; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thermodynamics; Uridine | 2001 |
Protein repair methyltransferase from the hyperthermophilic archaeon Pyrococcus furiosus. Unusual methyl-accepting affinity for D-aspartyl and N-succinyl-containing peptides.
Topics: Adenosine; Alanine; Archaeal Proteins; Deoxyadenosines; Enzyme Stability; Ethionine; Humans; Hydrogen-Ion Concentration; Methylation; Molecular Structure; Oligopeptides; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Pyrococcus furiosus; Recombinant Proteins; S-Adenosylhomocysteine; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Temperature; Thionucleosides | 2002 |
Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation.
Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Adenosylhomocysteinase; Arabidopsis; DNA, Complementary; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydrolases; Methylation; Mutation; Pectins; Phenotype; Plants, Genetically Modified; S-Adenosylhomocysteine; S-Adenosylmethionine; Seeds | 2002 |
Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha).
Topics: Adenosine; Alkaloids; Beverages; Caffeine; Camellia; Carbon Radioisotopes; Methylation; Molecular Structure; Plant Leaves; Staining and Labeling; Time Factors; Uric Acid | 2002 |
Antiadrenergic effects of adenosine A(1) receptor-mediated protein phosphatase 2a activation in the heart.
Topics: Adenosine; Adrenergic beta-Agonists; Animals; Calcium-Binding Proteins; Cantharidin; Enzyme Inhibitors; Female; In Vitro Techniques; Isoproterenol; Methylation; Muscle Fibers, Skeletal; Myocardium; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Wistar; Receptors, Purinergic P1; Troponin I | 2002 |
Coilin methylation regulates nuclear body formation.
Topics: Adenosine; Amino Acid Sequence; Animals; Arginine; Cell Line; Cell Nucleus; Cells, Cultured; Coiled Bodies; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Fibroblasts; Gene Deletion; Green Fluorescent Proteins; HeLa Cells; Humans; Luminescent Proteins; Methylation; Mice; Molecular Sequence Data; Mutation; Nerve Tissue Proteins; Nuclear Proteins; Peptides; Protein-Arginine N-Methyltransferases; RNA-Binding Proteins; SMN Complex Proteins; Transfection; Tumor Cells, Cultured | 2002 |
Exclusive interaction of the 15.5 kD protein with the terminal box C/D motif of a methylation guide snoRNP.
Topics: Adenosine; Animals; Base Sequence; Conserved Sequence; Methylation; Models, Molecular; Molecular Sequence Data; Molecular Weight; Nucleic Acid Conformation; Oocytes; Protein Binding; Recombinant Proteins; Ribonucleoproteins, Small Nuclear; RNA-Binding Proteins; RNA, Small Nucleolar; Thionucleotides; Xenopus | 2002 |
Changes in GE2270 antibiotic production in Planobispora rosea through modulation of methylation metabolism.
Topics: Actinomycetales; Adenosine; Anti-Bacterial Agents; Culture Media; Drug Interactions; Fermentation; Methionine; Methylation; Molecular Structure; Peptides; Peptides, Cyclic; Thiazoles; Vitamin B 12 | 2003 |
Expression and subcellular localization of Ewing sarcoma (EWS) protein is affected by the methylation process.
Topics: Adenosine; Cell Fractionation; Humans; Jurkat Cells; Leukocytes, Mononuclear; Methylation; Phytohemagglutinins; Protein Structure, Tertiary; RNA-Binding Protein EWS; Subcellular Fractions; T-Lymphocytes; Tumor Cells, Cultured | 2003 |
Pretreatment with periodate-oxidized adenosine enhances developmental toxicity of inorganic arsenic in mice.
Topics: Abnormalities, Drug-Induced; Adenosine; Animals; Arsenates; Arsenites; Body Weight; Embryonic and Fetal Development; Female; Male; Methylation; Mice; Muscle, Skeletal; Pregnancy; Pregnancy, Animal; Sodium Compounds; Teratogens | 2003 |
Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation.
Topics: Adenosine; Adherens Junctions; Animals; Cattle; Cell Membrane Permeability; Cells, Cultured; Cysteine; Diterpenes; Electrophoresis, Gel, Two-Dimensional; Endothelial Cells; Green Fluorescent Proteins; Homocysteine; Luminescent Proteins; Methylation; Protein Methyltransferases; rac1 GTP-Binding Protein; Recombinant Fusion Proteins; rhoA GTP-Binding Protein | 2004 |
Influence of an altered methylation potential on mRNA methylation and gene expression in HepG2 cells.
Topics: Adenosine; Adenosylhomocysteinase; Cell Line, Tumor; Cyclophilins; DNA Methylation; Down-Regulation; Erythropoietin; Gene Expression Regulation; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Transcription Factors; Up-Regulation; Vascular Endothelial Growth Factor A | 2004 |
Techniques in protein methylation.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; DNA-Binding Proteins; Enzyme Inhibitors; Glutathione Transferase; HeLa Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Methylation; Methyltransferases; Poly(A)-Binding Protein I; Precipitin Tests; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Recombinant Fusion Proteins; RNA-Binding Proteins; S-Adenosylmethionine; Signal Transduction; Substrate Specificity | 2004 |
S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease.
Topics: Adenosine; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Caspase 8; Caspases; Cell Line, Tumor; Hepatocytes; Homocysteine; Humans; Liver Diseases, Alcoholic; Methylation; Mice; Mice, Inbred C57BL; NF-kappa B; S-Adenosylhomocysteine; Tumor Necrosis Factor-alpha | 2004 |
Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism.
Topics: Adenosine; Autistic Disorder; Betaine; Biomarkers; Case-Control Studies; Child; Chromatography, High Pressure Liquid; Cystathionine; Cysteine; Female; Glutathione; Homocysteine; Humans; Leucovorin; Male; Methionine; Methylation; Oxidative Stress; S-Adenosylhomocysteine; S-Adenosylmethionine; Vitamin B 12 | 2004 |
Effects of adenosine dialdehyde treatment on in vitro and in vivo stable protein methylation in HeLa cells.
Topics: Adenosine; Arginine; Blotting, Western; Cycloheximide; Detergents; DNA Methylation; HeLa Cells; Humans; Methylation; Oxygen; Peptides; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Proteins; Time Factors; Trypsin | 2004 |
S-adenosylhomocysteine hydrolase from the archaeon Pyrococcus furiosus: biochemical characterization and analysis of protein structure by comparative molecular modeling.
Topics: Adenosine; Adenosylhomocysteinase; Amino Acid Sequence; Catalysis; Cloning, Molecular; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Homocysteine; Hot Temperature; Kinetics; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Pyrococcus; Pyrococcus furiosus; Recombinant Proteins; Sequence Homology, Amino Acid; Sulfolobus solfataricus; Temperature; Threonine | 2005 |
Encephalitozoon cuniculi mRNA cap (guanine N-7) methyltransferase: methyl acceptor specificity, inhibition BY S-adenosylmethionine analogs, and structure-guided mutational analysis.
Topics: Adenosine; Animals; Binding Sites; Crystallization; Encephalitozoon cuniculi; Enzyme Inhibitors; Guanosine Triphosphate; Hydrogen-Ion Concentration; Methylation; Methyltransferases; Models, Molecular; Molecular Structure; Mutagenesis; Mutation, Missense; Recombinant Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship; Substrate Specificity | 2005 |
Ligand-mediated anticodon conformational changes occur during tRNA methylation by a TrmD methyltransferase.
Topics: Adenosine; Amino Acid Sequence; Anticodon; Base Sequence; Escherichia coli Proteins; Fluorescence Resonance Energy Transfer; Ligands; Methylation; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Protein Conformation; Protein Footprinting; RNA-Binding Proteins; RNA, Transfer, Leu; S-Adenosylmethionine; Sequence Alignment; Thermotoga maritima; tRNA Methyltransferases | 2005 |
Regulation of trehalose metabolism by Adox and AdoMet in Saccharomyces cerevisiae.
Topics: Adenosine; Glucosyltransferases; Methylation; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Trehalase; Trehalose | 2005 |
DNA methyltransferase-moderated click chemistry.
Topics: Adenosine; Base Sequence; Chemistry; Cyclization; DNA; DNA Modification Methylases; Electrophoresis, Polyacrylamide Gel; Methylation; Molecular Structure | 2005 |
Effects of homocysteine on the dopaminergic system and behavior in rodents.
Topics: Adenosine; Animals; Behavior, Animal; Brain Chemistry; Catheterization; Chromatography, High Pressure Liquid; Dopamine; Homocysteine; Immunohistochemistry; Injections, Intraventricular; Male; Methylation; Mice; Mice, Inbred C57BL; Motor Activity; Neostriatum; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawley; Substantia Nigra; Tyrosine; Tyrosine 3-Monooxygenase | 2005 |
Inhibition of transmethylation disturbs neurulation in chick embryos.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Chick Embryo; Cycloleucine; Dose-Response Relationship, Drug; Drug Interactions; Embryonic Development; Homocysteine; Methylation; Models, Biological; Nervous System; Organogenesis; S-Adenosylhomocysteine; Time Factors; Tubercidin | 2005 |
Methyltransferase inhibition induces p53-dependent apoptosis and a novel form of cell death.
Topics: Actins; Adenosine; Apoptosis; bcl-2-Associated X Protein; Caspase Inhibitors; Caspases; Cell Nucleus; Cell Shape; Chromatin; Cytoplasm; G2 Phase; HeLa Cells; Humans; Methylation; Methyltransferases; Phenotype; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53 | 2005 |
o-nitrobenzenesulfonamides in nucleoside synthesis: efficient 5'-aziridination of adenosine.
Topics: Adenosine; Aziridines; DNA Nucleotidylexotransferase; Methylation; Methyltransferases; Molecular Mimicry; Mustard Plant; Nitrobenzenes; Nucleosides; S-Adenosylmethionine; Spectrum Analysis; Sulfonamides | 2005 |
Role of elevated S-adenosylhomocysteine in rat hepatocyte apoptosis: protection by betaine.
Topics: Adenosine; Animals; Apoptosis; Betaine; Caspase 3; Caspases; Cells, Cultured; Cytoprotection; DNA Fragmentation; Ethanol; Hepatocytes; Male; Methylation; Rats; Rats, Wistar; S-Adenosylhomocysteine | 2005 |
Dynamic changes in histone H3 lysine 9 methylations: identification of a mitosis-specific function for dynamic methylation in chromosome congression and segregation.
Topics: Adenosine; Animals; Antineoplastic Agents; Cell Line; Cell Line, Transformed; Chromosome Segregation; Chromosomes, Human; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Fluorescent Antibody Technique, Direct; Fluorescent Dyes; Green Fluorescent Proteins; HeLa Cells; Histones; Humans; Immunoblotting; Indoles; Lysine; Methylation; Mitosis; Muntjacs; Nocodazole; Protein Isoforms; Skin | 2006 |
S-Adenosylmethionine and betaine correct hepatitis C virus induced inhibition of interferon signaling in vitro.
Topics: Adenosine; Antiviral Agents; Betaine; Cell Line; DNA; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon-alpha; Liver; Methylation; Phosphoprotein Phosphatases; Protein Phosphatase 2C; Protein-Arginine N-Methyltransferases; S-Adenosylmethionine; Signal Transduction; STAT1 Transcription Factor; Virus Replication | 2006 |
Mutational analysis of Encephalitozoon cuniculi mRNA cap (guanine-N7) methyltransferase, structure of the enzyme bound to sinefungin, and evidence that cap methyltransferase is the target of sinefungin's antifungal activity.
Topics: Adenosine; Antifungal Agents; Binding Sites; Crystallography, X-Ray; DNA Mutational Analysis; Encephalitozoon cuniculi; Guanine; Kinetics; Methylation; Methyltransferases; Models, Molecular; Mutation; Protein Binding; Saccharomyces cerevisiae | 2006 |
Role of S-adenosylhomocysteine hydrolase in adenosine-induced apoptosis in HepG2 cells.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosylhomocysteinase; Apoptosis; Caspase Inhibitors; Caspases; Dipyridamole; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Homocysteine; Humans; Methylation; Nucleoside Transport Proteins; Oligonucleotide Array Sequence Analysis; Pentostatin; Proto-Oncogene Proteins c-mdm2; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine | 2007 |
Protein methylation is required to maintain optimal HIV-1 infectivity.
Topics: Adenosine; Cell Line; Fusion Proteins, gag-pol; Gene Products, vpr; HeLa Cells; HIV-1; Humans; Methylation; Methyltransferases; Periodic Acid; Proteins; T-Lymphocytes; Virion; vpr Gene Products, Human Immunodeficiency Virus | 2006 |
Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation.
Topics: Adenosine; Amino Acid Substitution; Animals; Antiviral Agents; Cell Line; Cricetinae; Drug Resistance, Viral; Enzyme Inhibitors; Methylation; Mutation; Promoter Regions, Genetic; RNA Caps; RNA-Dependent RNA Polymerase; RNA, Viral; Streptomyces; Vesicular stomatitis Indiana virus; Viral Matrix Proteins; Viral Plaque Assay; Viral Proteins; Virus Replication | 2007 |
Kinetic manifestation of processivity during multiple methylations catalyzed by SET domain protein methyltransferases.
Topics: Adenosine; Animals; Catalysis; Cattle; Cell Cycle Proteins; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Kinetics; Lysine; Methylation; Methyltransferases; Models, Chemical; Multienzyme Complexes; Pisum sativum; Plant Proteins; Protein Methyltransferases; Protein Structure, Tertiary; S-Adenosylhomocysteine; Schizosaccharomyces pombe Proteins | 2007 |
Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.
Topics: Adenosine; Adenosylhomocysteinase; Apoptosis; Base Sequence; Breast Neoplasms; Cell Line, Tumor; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; Enzyme Inhibitors; Epigenesis, Genetic; Female; Histones; Humans; Methylation; Polycomb-Group Proteins; Promoter Regions, Genetic; Repressor Proteins; RNA Interference; RNA Polymerase II; RNA, Small Interfering | 2007 |
Adenosine metabolism and its effect on methylation potential in cultured cells: methodological considerations.
Topics: Adenine Nucleotides; Adenosine; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Line, Tumor; Chelating Agents; Culture Media; Edetic Acid; Humans; Inosine; Kinetics; Liver Neoplasms; Methylation; S-Adenosylmethionine; Time Factors; Trypsin | 2007 |
Exoribonuclease R in Mycoplasma genitalium can carry out both RNA processing and degradative functions and is sensitive to RNA ribose methylation.
Topics: Adenosine; Bacterial Proteins; Base Sequence; Escherichia coli Proteins; Exoribonucleases; Methylation; Methyltransferases; Molecular Sequence Data; Mycoplasma genitalium; Nucleic Acid Conformation; Polymers; RNA Precursors; RNA Processing, Post-Transcriptional; RNA, Bacterial; RNA, Ribosomal | 2007 |
One-electron reduction of 8-bromo-2-aminoadenosine in the aqueous phase: radiation chemical and DFT studies of the mechanism.
Topics: Acids; Adenosine; Alkalies; Electrons; Hydrogen-Ion Concentration; Ions; Isotopes; Methylation; Models, Molecular; Molecular Structure; Oxidation-Reduction; Solutions; Stereoisomerism; Water | 2008 |
Targeting the methionine cycle for melanoma therapy with 3-O-(3,4,5-trimethoxybenzoyl)-(-)-epicatechin.
Topics: Adenosine; Animals; Antineoplastic Agents; Apoptosis; Base Sequence; Blotting, Western; Caspase 3; Catechin; Cell Line, Tumor; DNA Primers; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Melanoma; Methionine; Methylation; Mice; Microscopy, Confocal; Microscopy, Electron; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.
Topics: Adenosine; Binding Sites; Biochemistry; Dengue Virus; Enzyme Inhibitors; Guanosine Triphosphate; Kinetics; Methylation; Methyltransferases; S-Adenosylhomocysteine; Scintillation Counting; Sensitivity and Specificity; Viral Proteins | 2008 |
Chemical synthesis of diastereomeric diadenosine boranophosphates (ApbA) from 2'-O-(2-cyanoethoxymethyl)adenosine by the boranophosphotriester method.
Topics: Adenosine; Boranes; Cyanides; Esterases; Ethyl Ethers; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Nucleic Acid Denaturation; Phosphates; Stereoisomerism; Substrate Specificity | 2008 |
S-adenosyl homocysteine-induced hyperpolyadenylation of vesicular stomatitis virus mRNA requires the methyltransferase activity of L protein.
Topics: Adenosine; Animals; Cell Line; Chlorocebus aethiops; Cricetinae; Methylation; Models, Molecular; Polymers; Protein Methyltransferases; Protein Structure, Tertiary; RNA-Dependent RNA Polymerase; RNA, Messenger; S-Adenosylhomocysteine; Substrate Specificity; Transcription, Genetic; Vesiculovirus; Viral Proteins | 2008 |
Methyltransferase-inhibition interferes with neuronal differentiation of P19 embryonal carcinoma cells.
Topics: Adenosine; Animals; Cadherins; Carcinoma, Embryonal; Cell Communication; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Mesoderm; Methylation; Methyltransferases; Mice; Neurogenesis; Neuroglia; Neurons; RNA, Messenger; Transcription, Genetic | 2008 |
Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria.
Topics: Adenosine; Anti-Bacterial Agents; Catalysis; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Methylation; Methyltransferases; Nucleic Acid Conformation; RNA, Ribosomal, 23S; Spectrometry, Mass, Electrospray Ionization | 2009 |
Protein phosphatase 2A contributes to the cardiac dysfunction induced by endotoxemia.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Endotoxemia; Isoquinolines; Lipopolysaccharides; Methylation; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocytes, Cardiac; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Methyltransferases; Protein Phosphatase 2; Protein Phosphatase 2C; Protein Processing, Post-Translational; Receptor, Adenosine A1; Sulfonamides; Time Factors; Troponin I | 2009 |
The yfiC gene of E. coli encodes an adenine-N6 methyltransferase that specifically modifies A37 of tRNA1Val(cmo5UAC).
Topics: Adenosine; Escherichia coli; Escherichia coli Proteins; Genes, Bacterial; Methylation; Methyltransferases; Oxidative Stress; RNA, Transfer, Val; tRNA Methyltransferases | 2009 |
DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.
Topics: Adenosine; Azacitidine; Blotting, Western; Cell Line; Cell Line, Tumor; Decitabine; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Keratin-7; Methylation; Molecular Structure; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2009 |
Arginine methylation analysis of the splicing-associated SR protein SFRS9/SRP30C.
Topics: Active Transport, Cell Nucleus; Adenosine; Amino Acid Sequence; Arginine; Cell Line; Humans; Methylation; Molecular Sequence Data; Nuclear Proteins; Protein Isoforms; RNA Splicing; RNA-Binding Proteins; Sequence Alignment; Serine-Arginine Splicing Factors | 2009 |
G2 histone methylation is required for the proper segregation of chromosomes.
Topics: Adenosine; Chromosomal Proteins, Non-Histone; Chromosome Segregation; DNA; G2 Phase; HeLa Cells; Histones; Humans; Kinetochores; Methylation; Mitosis; Protein Processing, Post-Translational; Time Factors | 2009 |
Synergistic effects of homocysteine, S-adenosylhomocysteine and adenosine on apoptosis in BV-2 murine microglial cells.
Topics: Adenosine; Animals; Apoptosis; Caspase 3; Caspase 9; Cell Line; Cell Survival; Drug Synergism; Homocysteine; Methylation; Mice; Microglia; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; S-Adenosylhomocysteine | 2008 |
Preparation of eukaryotic mRNA having differently methylated adenosine at the 5'-terminus and the effect of the methyl group in translation.
Topics: Adenosine; Animals; Luciferases; Methylation; Protein Biosynthesis; Rabbits; RNA Cap Analogs | 2009 |
Combinatorial pharmacologic approaches target EZH2-mediated gene repression in breast cancer cells.
Topics: Adenosine; Antigens, Neoplasm; Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Cluster Analysis; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Methylation; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factors | 2009 |
Regulation of pre-mRNA splicing in Xenopus oocytes by targeted 2'-O-methylation.
Topics: Adenosine; Adenoviridae; Animals; Base Sequence; Female; Gene Expression; Humans; In Vitro Techniques; Methylation; Models, Biological; Nucleic Acid Conformation; Oocytes; Plasmids; RNA Precursors; RNA Splicing; RNA, Small Nucleolar; RNA, Viral; Spliceosomes; Xenopus | 2010 |
Higher catalytic efficiency of N-7-methylation is responsible for processive N-7 and 2'-O methyltransferase activity in dengue virus.
Topics: Adenosine; Animals; Dengue Virus; Enzyme Inhibitors; Inhibitory Concentration 50; Kinetics; Methylation; Methyltransferases; RNA; S-Adenosylmethionine; Viral Proteins | 2010 |
Yeast targets for mRNA methylation.
Topics: Adenosine; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Methylation; Protein Serine-Threonine Kinases; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spores, Fungal | 2010 |
Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs.
Topics: Adenosine; Cell Line; Genome-Wide Association Study; Humans; Methylation; Methyltransferases; Oligonucleotide Array Sequence Analysis; Protein Biosynthesis; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Transfer | 2010 |
Possible regulation of trehalose metabolism by methylation in Saccharomyces cerevisiae.
Topics: Adenosine; Cell Proliferation; Gene Expression Regulation, Fungal; Hydrogen-Ion Concentration; Methylation; Protein Processing, Post-Translational; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Trehalose | 2011 |
Proteomic identification and comparative analysis of asymmetrically arginine-methylated proteins in immortalized, young and senescent cells.
Topics: Adenosine; Arginine; Blotting, Western; Cell Line, Transformed; Cell Proliferation; Cellular Senescence; Chaperonin Containing TCP-1; Cleavage Stimulation Factor; Humans; Hydrogen Peroxide; Immunoprecipitation; Methylation; Molecular Chaperones; Protein-Arginine N-Methyltransferases; RNA-Binding Proteins | 2010 |
Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy.
Topics: Adenosine; Base Sequence; Blotting, Western; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Histones; Humans; Hydroxamic Acids; Indoles; Intracellular Signaling Peptides and Proteins; Leukemia-Lymphoma, Adult T-Cell; Lysine; Methylation; MicroRNAs; Oligonucleotide Array Sequence Analysis; Panobinostat; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2011 |
Structure and mechanism of the chalcogen-detoxifying protein TehB from Escherichia coli.
Topics: Adenosine; Biocatalysis; Catalytic Domain; Chalcogens; Consensus Sequence; Crystallography, X-Ray; Drug Resistance, Bacterial; Escherichia coli K12; Escherichia coli Proteins; Kinetics; Methylation; Mutagenesis, Site-Directed; Mutant Proteins; Organoselenium Compounds; Protein Conformation; Recombinant Proteins; S-Adenosylhomocysteine; Sequence Alignment; Sequence Homology, Amino Acid; Tellurium | 2011 |
A radically different mechanism for S-adenosylmethionine-dependent methyltransferases.
Topics: Adenosine; Bacterial Proteins; Biocatalysis; Carbon; Chemical Phenomena; Cysteine; Escherichia coli; Escherichia coli Proteins; Hydrogen; Methylation; Methyltransferases; RNA, Bacterial; RNA, Ribosomal, 23S; S-Adenosylmethionine; Staphylococcus aureus | 2011 |
Biochemistry. The two faces of SAM.
Topics: Adenine; Adenosine; Bacterial Proteins; Biocatalysis; Catalytic Domain; Chemical Phenomena; Cysteine; Drug Resistance, Multiple, Bacterial; Escherichia coli; Escherichia coli Proteins; Methylation; Methyltransferases; RNA, Bacterial; RNA, Ribosomal, 23S; S-Adenosylmethionine; Staphylococcus aureus | 2011 |
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Cell Nucleus; HeLa Cells; Humans; Methylation; Obesity; Oxidation-Reduction; Proteins; RNA, Messenger; Substrate Specificity | 2011 |
Inhibition of histone methylation arrests ongoing graft-versus-host disease in mice by selectively inducing apoptosis of alloreactive effector T cells.
Topics: Adenosine; Animals; Apoptosis; Cells, Cultured; Disease Progression; Enzyme Inhibitors; Graft vs Host Disease; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Isoantigens; Lymphocyte Activation; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Substrate Specificity; T-Lymphocytes; Up-Regulation | 2012 |
High-resolution structures of complexes of plant S-adenosyl-L-homocysteine hydrolase (Lupinus luteus).
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Crystallography, X-Ray; Deoxyadenosines; Hydrolases; Lupinus; Methylation; Models, Molecular; Molecular Conformation; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine | 2012 |
2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase.
Topics: Adenosine; Animals; Cell Line; Dengue Virus; Humans; Insecta; Methylation; RNA, Viral; tRNA Methyltransferases; Viral Nonstructural Proteins; Virion; West Nile virus | 2012 |
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.
Topics: Adenosine; Alternative Splicing; Animals; Base Sequence; Cell Line, Tumor; Conserved Sequence; Evolution, Molecular; Hep G2 Cells; Humans; Metabolome; Methylation; Methyltransferases; Mice; RNA; RNA-Binding Proteins; RNA, Ribosomal; RNA, Transfer; Transcriptome | 2012 |
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.
Topics: 3' Untranslated Regions; Adenosine; Codon, Terminator; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Untranslated; Transcriptome | 2012 |
TP53 genomic status regulates sensitivity of gastric cancer cells to the histone methylation inhibitor 3-deazaneplanocin A (DZNep).
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Immunoblotting; Male; Methylation; Middle Aged; Mutation; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Stomach Neoplasms; Tumor Suppressor Protein p53; Ubiquitination; Young Adult | 2012 |
TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification.
Topics: Adenosine; Animals; Drug Resistance, Multiple, Bacterial; Erythromycin; Guanosine; Lincosamides; Macrolides; Methylation; Mice; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus; Streptogramins; Toll-Like Receptors | 2012 |
Efflux of glutathione and glutathione complexes from human erythrocytes in response to vanadate.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Adenosine; Biological Transport; Cells, Cultured; Chloride-Bicarbonate Antiporters; Dose-Response Relationship, Drug; Erythrocytes; Glutathione; Humans; L-Lactate Dehydrogenase; Methylation; Multidrug Resistance-Associated Proteins; Propionates; Quinolines; Succimer; Sulfhydryl Compounds; Vanadates | 2013 |
Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.
Topics: Adenosine; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; G1 Phase Cell Cycle Checkpoints; Gene Expression; Gene Knockdown Techniques; Histones; Humans; Inhibitory Concentration 50; Lung Neoplasms; Methylation; Neoplasm Proteins; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; RNA Interference; Transcription Factors | 2012 |
FTO, RNA epigenetics and epilepsy.
Topics: 3' Untranslated Regions; Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Central Nervous System; Epigenesis, Genetic; Epilepsy; Gene Expression Regulation; Humans; Methylation; MicroRNAs; Proteins; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome | 2012 |
Dysregulation of the repressive H3K27 trimethylation mark in head and neck squamous cell carcinoma contributes to dysregulated squamous differentiation.
Topics: Adenosine; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Histones; Humans; Methylation; Mice; Polycomb Repressive Complex 2; RNA Interference; Squamous Cell Carcinoma of Head and Neck; Transplantation, Heterologous | 2013 |
Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing.
Topics: Adenosine; Animals; Gene Expression Profiling; Humans; Immunoprecipitation; Methylation; Mice; RNA Processing, Post-Transcriptional | 2013 |
Involvement of Src and the actin cytoskeleton in the antitumorigenic action of adenosine dialdehyde.
Topics: Actin Cytoskeleton; Adenosine; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Cell Line, Tumor; Humans; Methylation; Phosphorylation; Rats; S-Adenosylhomocysteine; src-Family Kinases | 2013 |
MeRIP-PF: an easy-to-use pipeline for high-resolution peak-finding in MeRIP-Seq data.
Topics: Adenosine; Animals; Methylation; Mice; Molecular Sequence Annotation; RNA; RNA, Messenger; Sequence Analysis, RNA; Software | 2013 |
Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.
Topics: Adenosine; Amyotrophic Lateral Sclerosis; Animals; Arginine; Cytosol; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Enzyme Inhibitors; Gene Deletion; Gene Knockdown Techniques; HEK293 Cells; Humans; Inclusion Bodies; Membrane Proteins; Methylation; Methyltransferases; Mutant Proteins; Mutation; Protein Binding; Protein Transport; Protein-Arginine N-Methyltransferases; Repressor Proteins; RNA-Binding Protein FUS; Subcellular Fractions | 2013 |
FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Humans; Kinetics; Mammals; Methylation; Mice; Models, Biological; Molecular Dynamics Simulation; Oxidation-Reduction; Protein Binding; Proteins; RNA; RNA-Binding Proteins; RNA, Messenger; Substrate Specificity | 2013 |
EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers.
Topics: Actin Cytoskeleton; Adenosine; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Gene Expression Regulation, Neoplastic; GTPase-Activating Proteins; Histones; Humans; Methylation; Neoplasms; Promoter Regions, Genetic; RNA, Messenger; Tumor Suppressor Proteins | 2013 |
Modulation of allogeneic CD8+ T-cell response by DZNep controls GVHD while preserving hematopoietic chimerism.
Topics: Adenosine; Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Fas Ligand Protein; Female; Graft vs Host Disease; Granzymes; Hematopoietic Stem Cell Transplantation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunosuppressive Agents; Interferon-gamma; Interleukin-2; Lymphocyte Activation; Male; Methylation; Mice; Mice, Inbred C3H; T-Lymphocytes, Cytotoxic; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transplantation Chimera; Transplantation Tolerance; Transplantation, Homologous; Tumor Necrosis Factor-alpha | 2013 |
DZNep, inhibitor of S-adenosylhomocysteine hydrolase, down-regulates expression of SETDB1 H3K9me3 HMTase in human lung cancer cells.
Topics: Adenosine; Adenosylhomocysteinase; Cell Death; Cell Line, Tumor; Down-Regulation; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung; Lung Neoplasms; Methylation; Promoter Regions, Genetic; Protein Methyltransferases | 2013 |
Adenosine dialdehyde suppresses MMP-9-mediated invasion of cancer cells by blocking the Ras/Raf-1/ERK/AP-1 signaling pathway.
Topics: Adenosine; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Coenzyme A Ligases; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 9; MCF-7 Cells; Methylation; Phosphorylation; Protein Methyltransferases; Proto-Oncogene Proteins c-raf; ras Proteins; RNA, Small Interfering; Signal Transduction; Transcription Factor AP-1; Tubercidin | 2013 |
Metabolism of selenite to selenosugar and trimethylselenonium in vivo: tissue dependency and requirement for S-adenosylmethionine-dependent methylation.
Topics: Adenosine; Animals; Dietary Supplements; Erythrocytes; Kidney; Liver; Male; Methylation; Molecular Weight; Organoselenium Compounds; Rats; Rats, Sprague-Dawley; RNA, Messenger; S-Adenosylhomocysteine; S-Adenosylmethionine; Selenious Acid; Selenium; Selenium Compounds; Selenoproteins | 2013 |
Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA.
Topics: Adenosine; Base Sequence; Consensus Sequence; HEK293 Cells; HeLa Cells; Humans; Inverted Repeat Sequences; Methylation; Molecular Sequence Data; Nucleic Acid Conformation; RNA Processing, Post-Transcriptional; RNA, Long Noncoding; RNA, Messenger; Staining and Labeling | 2013 |
Method for site-specific detection of m6A nucleoside presence in RNA based on high-resolution melting (HRM) analysis.
Topics: Adenosine; HEK293 Cells; Humans; Methylation; Methyltransferases; Nucleic Acid Hybridization; Oligonucleotide Probes; RNA | 2014 |
High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis.
Topics: Adenosine; Cell Nucleolus; Genome, Fungal; Meiosis; Methylation; Nuclear Proteins; RNA, Fungal; RNA, Messenger; Saccharomyces; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; tRNA Methyltransferases | 2013 |
Identification of truncated forms of U1 snRNA reveals a novel RNA degradation pathway during snRNP biogenesis.
Topics: Adenosine; Cytoplasm; Guanosine; Mass Spectrometry; Methylation; Ribonucleoproteins, Small Nuclear; RNA Stability; RNA, Small Nuclear; SMN Complex Proteins | 2014 |
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Topics: Adenosine; Animals; Base Sequence; Binding Sites; Cell Nucleus; Enzyme Stability; HeLa Cells; Humans; Methylation; Methyltransferases; Models, Molecular; Multienzyme Complexes; RNA | 2014 |
Identification of a selective polymerase enables detection of N(6)-methyladenosine in RNA.
Topics: Adenosine; Base Sequence; DNA-Directed DNA Polymerase; Humans; Methylation; RNA; RNA, Messenger; Substrate Specificity; Thermus thermophilus; Thymidine | 2013 |
Regulation of PP2AC carboxylmethylation and cellular localisation by inhibitory class G-protein coupled receptors in cardiomyocytes.
Topics: Adenosine; Analysis of Variance; Animals; Blotting, Western; Chromones; Cytoplasm; Immunoprecipitation; Methylation; Morpholines; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein O-Methyltransferase; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Rats; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Signal Transduction | 2014 |
Molecular biology. Internal mRNA methylation finally finds functions.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Cell Nucleus; Cytoplasm; Dioxygenases; Gene Knockdown Techniques; Humans; Membrane Proteins; Methylation; Methyltransferases; Mice; Proteins; RNA Stability; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic | 2014 |
Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA.
Topics: Adenosine; Amino Acids; Aminoglycosides; Biocatalysis; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Proteins; Gene Transfer, Horizontal; Methylation; Methyltransferases; Models, Molecular; Nucleotides; Protein Structure, Secondary; Protein Structure, Tertiary; Ribosome Subunits, Small, Bacterial; RNA, Ribosomal, 16S; Structure-Activity Relationship | 2014 |
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Binding Sites; Catalysis; Crystallography, X-Ray; Dioxygenases; DNA, Single-Stranded; Humans; Membrane Proteins; Methylation; Mutagenesis; Protein Binding; Protein Structure, Secondary; RNA; Structure-Activity Relationship | 2014 |
Characterization of a cross-linked protein-nucleic acid substrate radical in the reaction catalyzed by RlmN.
Topics: Adenosine; Biocatalysis; Cross-Linking Reagents; Crystallization; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Escherichia coli Proteins; Methylation; Methyltransferases; Models, Molecular; Protein Conformation; RNA, Ribosomal, 23S; Substrate Specificity | 2014 |
Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs.
Topics: Adenosine; Binding Sites; Codon; Escherichia coli Proteins; HeLa Cells; Humans; Methylation; Proteins; RNA, Transfer, Ser; RNA, Transfer, Thr; S-Adenosylmethionine; Substrate Specificity; tRNA Methyltransferases | 2014 |
EZH2-induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in ovarian cancer.
Topics: Adenosine; Carcinogenesis; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Female; Gene Knockdown Techniques; Histones; Humans; Lysine; Methylation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Polycomb Repressive Complex 2; rho GTP-Binding Proteins; RNA, Small Interfering; Survival Analysis; Tumor Suppressor Proteins | 2015 |
The specific alteration of histone methylation profiles by DZNep during early zebrafish development.
Topics: Adenosine; Animals; Embryo, Nonmammalian; Embryonic Development; Gene Expression Regulation, Developmental; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Methylation; Promoter Regions, Genetic; Transcriptome; Zebrafish | 2014 |
Increased plasma S-adenosylhomocysteine-accelerated atherosclerosis is associated with epigenetic regulation of endoplasmic reticulum stress in apoE-/- mice.
Topics: Adenosine; Adenosylhomocysteinase; Animals; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Binding Sites; CCAAT-Enhancer-Binding Proteins; Cell Line; Disease Models, Animal; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Heat-Shock Proteins; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Male; Methylation; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; S-Adenosylhomocysteine; Time Factors; Up-Regulation | 2015 |
Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L.
Topics: Adenosine; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Phenylurea Compounds; Wnt Signaling Pathway | 2015 |
MeT-DB: a database of transcriptome methylation in mammalian cells.
Topics: Adenosine; Animals; Binding Sites; Databases, Nucleic Acid; Gene Expression Profiling; Humans; Immunoprecipitation; Methylation; Mice; MicroRNAs; RNA-Binding Proteins; RNA, Messenger; Sequence Analysis, RNA | 2015 |
Solution structure of the YTH domain in complex with N6-methyladenosine RNA: a reader of methylated RNA.
Topics: Adenosine; Animals; Binding Sites; Guanine; Methylation; Models, Molecular; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Tertiary; Rats; RNA; RNA-Binding Proteins; Serine-Arginine Splicing Factors | 2014 |
Structure-guided DOT1L probe optimization by label-free ligand displacement.
Topics: Adenosine; Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation, Neoplastic; High-Throughput Screening Assays; Histone-Lysine N-Methyltransferase; Histones; Humans; Ligands; Methylation; Methyltransferases; Models, Molecular; Phenylurea Compounds; Recombinant Fusion Proteins; S-Adenosylmethionine; Small Molecule Libraries; Structure-Activity Relationship | 2015 |
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis.
Topics: Adenosine; Adipocytes; Adipogenesis; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Cell Line; Core Binding Factor Alpha 2 Subunit; Methylation; Mice; Mixed Function Oxygenases; Oxo-Acid-Lyases; RNA Splicing; RNA, Messenger | 2014 |
AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes.
Topics: Adenosine; Animals; Bone Marrow Cells; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; HL-60 Cells; Homeodomain Proteins; Humans; Leukemia, Myeloid, Acute; Methylation; Methyltransferases; Mice; Mice, Transgenic; Molecular Sequence Data; Neoplasms, Experimental; Nuclear Pore Complex Proteins; Nuclear Proteins; Oncogene Proteins, Fusion; Phenylurea Compounds; Transcription Factors | 2014 |
Epigenetic alterations of the keratin 13 gene in oral squamous cell carcinoma.
Topics: Adenosine; Carcinoma, Squamous Cell; Cell Line, Tumor; CpG Islands; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Keratin-13; Methylation; Mouth Neoplasms; Promoter Regions, Genetic; Transcriptional Activation | 2014 |
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation.
Topics: Adenosine; Animals; Blastocyst; Cell Differentiation; Cell Line; Embryo Loss; Epigenesis, Genetic; Female; Gene Knockout Techniques; Male; Methylation; Methyltransferases; Mice; Mice, Knockout; Pluripotent Stem Cells; RNA, Messenger | 2015 |
Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification.
Topics: Adenine; Adenosine; Base Pairing; Cell Line; Humans; Methylation; Models, Molecular; Ribonucleases; RNA; RNA Stability; Thermodynamics | 2015 |
N6-adenosine methylation in MiRNAs.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Epigenesis, Genetic; Gene Knockdown Techniques; HEK293 Cells; Humans; Methylation; MicroRNAs; Proteins; RNA Stability; RNA, Messenger | 2015 |
mRNA m⁶A methylation downregulates adipogenesis in porcine adipocytes.
Topics: Adenosine; Adipocytes; Adipogenesis; Animals; Betaine; Cells, Cultured; Cycloleucine; Down-Regulation; Gene Knockdown Techniques; Lipid Metabolism; Methylation; Methyltransferases; RNA, Messenger; Swine | 2015 |
N6-methyladenosine marks primary microRNAs for processing.
Topics: Adenosine; Base Sequence; Cell Line; Gene Expression Regulation; Humans; Methylation; Methyltransferases; MicroRNAs; Molecular Sequence Data; Nucleic Acid Conformation; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; Substrate Specificity | 2015 |
A role for KMT1c in monocyte to dendritic cell differentiation: Epigenetic regulation of monocyte differentiation.
Topics: Acetylation; Adenosine; Azepines; Cell Adhesion Molecules; Cell Differentiation; Chromatin; Chromatin Assembly and Disassembly; Dendritic Cells; Epigenesis, Genetic; Gene Expression Profiling; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Lectins, C-Type; Methylation; Monocytes; Primary Cell Culture; Quinazolines; Receptors, Cell Surface; Signal Transduction; Transcription, Genetic | 2015 |
FTO-dependent function of N6-methyladenosine is involved in the hepatoprotective effects of betaine on adolescent mice.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Betaine; Blood Glucose; Cholesterol; Cytoprotection; Diet, High-Fat; Drug Evaluation, Preclinical; Female; Gene Expression; Hepatocytes; Lipid Metabolism; Liver; Methylation; Mice, Inbred C57BL; Mixed Function Oxygenases; Non-alcoholic Fatty Liver Disease; Oxo-Acid-Lyases; RNA Processing, Post-Transcriptional; RNA, Messenger; Weight Gain | 2015 |
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome.
Topics: Adenosine; Animals; Antibodies; Cross-Linking Reagents; DNA Mutational Analysis; HEK293 Cells; Humans; Methylation; Mice; Mutation; Nucleotide Mapping; RNA, Messenger; RNA, Small Nucleolar; Sequence Analysis, DNA; Transcription, Genetic; Transcriptome; Ultraviolet Rays | 2015 |
Structural basis for methyl-donor-dependent and sequence-specific binding to tRNA substrates by knotted methyltransferase TrmD.
Topics: Adenosine; Amino Acid Sequence; Anticodon; Base Sequence; Binding Sites; Biocatalysis; Crystallography, X-Ray; Escherichia coli Proteins; Guanine; Haemophilus influenzae; Kinetics; Methylation; Models, Molecular; Molecular Sequence Data; RNA, Transfer; S-Adenosylmethionine; Sequence Alignment; Structure-Activity Relationship; Substrate Specificity; Thermotoga maritima; tRNA Methyltransferases | 2015 |
Circadian rhythm of RNA N6-methyladenosine and the role of cryptochrome.
Topics: Adenosine; Animals; Circadian Rhythm; Cryptochromes; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Biosynthesis; RNA; Signal Transduction; Transcription, Genetic | 2015 |
Transcriptome-Wide Mapping of N⁶-Methyladenosine by m⁶A-Seq.
Topics: Adenosine; High-Throughput Nucleotide Sequencing; Methylation; RNA; Transcriptome | 2015 |
Radical SAM-Mediated Methylation of Ribosomal RNA.
Topics: Adenosine; Catalysis; Escherichia coli Proteins; Methylation; Methyltransferases; RNA Processing, Post-Transcriptional; RNA, Ribosomal; S-Adenosylmethionine; tRNA Methyltransferases | 2015 |
Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A.
Topics: Adenosine; Cell Line, Tumor; Cell Proliferation; Chemokine CXCL10; CpG Islands; Histones; Humans; Lysine; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Up-Regulation | 2015 |
iRNA-Methyl: Identifying N(6)-methyladenosine sites using pseudo nucleotide composition.
Topics: Adenosine; Algorithms; Binding Sites; Entropy; Epigenomics; Genome, Bacterial; Internet; Machine Learning; Methylation; Methyltransferases; Models, Molecular; Nucleotide Motifs; Reproducibility of Results; RNA Processing, Post-Transcriptional; RNA, Bacterial; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity | 2015 |
HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events.
Topics: Adenosine; Alternative Splicing; Cell Line, Tumor; Cell Nucleus; HEK293 Cells; HeLa Cells; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Methylation; RNA; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; Transcriptome | 2015 |
Identification and analysis of the N(6)-methyladenosine in the Saccharomyces cerevisiae transcriptome.
Topics: Adenosine; Computational Biology; Gene Expression Profiling; Methylation; Nucleotide Motifs; Nucleotides; Position-Specific Scoring Matrices; ROC Curve; Saccharomyces cerevisiae; Transcriptome; Web Browser | 2015 |
Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Binding Sites; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; HT29 Cells; Humans; Methylation; Methyltransferases; MicroRNAs; Oligopeptides; Oligoribonucleotides; Protein Binding; Receptor, PAR-2; RNA, Neoplasm; RNA, Small Interfering; Signal Transduction; Tumor Microenvironment | 2015 |
The beneficial effects of betaine on dysfunctional adipose tissue and N6-methyladenosine mRNA methylation requires the AMP-activated protein kinase α1 subunit.
Topics: Adenosine; Adipocytes; Adipose Tissue; AMP-Activated Protein Kinases; Animals; Betaine; Body Weight; Diet, High-Fat; DNA Methylation; Gastrointestinal Agents; Glucose Tolerance Test; Insulin; Lipid Metabolism; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; RNA, Messenger | 2015 |
Dynamic m(6)A mRNA methylation directs translational control of heat shock response.
Topics: 5' Untranslated Regions; Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Cell Line; Cell Nucleus; Fibroblasts; Gene Expression Regulation; Heat-Shock Response; HSP70 Heat-Shock Proteins; Methylation; Mice; Mixed Function Oxygenases; Oxo-Acid-Lyases; Peptide Chain Initiation, Translational; RNA Caps; RNA-Binding Proteins; RNA, Messenger; Transcription, Genetic | 2015 |
Probing N⁶-methyladenosine (m⁶A) RNA Modification in Total RNA with SCARLET.
Topics: Adenosine; Chromatography, Thin Layer; HeLa Cells; Humans; Methylation; Radioisotopes; RNA Processing, Post-Transcriptional; RNA, Long Noncoding; RNA, Messenger | 2016 |
16S rRNA methyltransferase KsgA contributes to oxidative stress resistance and virulence in Staphylococcus aureus.
Topics: Acetylcysteine; Adenosine; Animals; Bacterial Proteins; Bombyx; Gene Knockout Techniques; Isoenzymes; Larva; Macrophages; Methylation; Methyltransferases; Mice; Microbial Viability; Oxidative Stress; Phagocytosis; Protein Biosynthesis; RAW 264.7 Cells; RNA Processing, Post-Transcriptional; RNA, Bacterial; RNA, Ribosomal, 16S; Staphylococcus aureus; Virulence | 2015 |
Treatment with a Global Methyltransferase Inhibitor Induces the Intranuclear Aggregation of ALS-Linked FUS Mutant In Vitro.
Topics: Adenosine; Amyotrophic Lateral Sclerosis; Cell Line, Tumor; Cell Nucleus; HEK293 Cells; Humans; Methylation; Methyltransferases; Mutation; Protein Aggregates; RNA-Binding Protein FUS; Subcellular Fractions; Time Factors | 2016 |
Transcriptome-wide high-throughput deep m(6)A-seq reveals unique differential m(6)A methylation patterns between three organs in Arabidopsis thaliana.
Topics: Adenosine; Arabidopsis; DNA Transposable Elements; Flowers; Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Methylation; Plant Leaves; Plant Roots; RNA, Plant; Sequence Analysis, RNA | 2015 |
Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue.
Topics: Adenosine; Archaeal Proteins; Catalytic Domain; Crystallography, X-Ray; Methylation; Models, Molecular; Molecular Docking Simulation; Protein Structure, Tertiary; RNA, Transfer; RNA, Transfer, Met; Scattering, Small Angle; Sulfolobus acidocaldarius; tRNA Methyltransferases; X-Ray Diffraction | 2016 |
The Synthesis of Both Diastereomers of 5'-Methylhomoaristeromycin.
Topics: Adenosine; Antiviral Agents; Humans; Methylation; Oxazolidinones; Stereoisomerism; Titanium; Virus Diseases; Viruses | 2016 |
The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA.
Topics: 5' Untranslated Regions; Adenosine; Animals; Base Sequence; Cell Line; Cell Line, Tumor; Codon, Initiator; Conserved Sequence; Epigenesis, Genetic; Evolution, Molecular; GC Rich Sequence; Humans; Methylation; Mice; Organ Specificity; Peptide Chain Initiation, Translational; RNA Splice Sites; RNA, Messenger; Saccharomyces cerevisiae; Transcriptome | 2016 |
Transcriptome-wide mapping reveals reversible and dynamic N(1)-methyladenosine methylome.
Topics: Adenosine; AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase; Antibodies; Base Sequence; Cell Line; Dioxygenases; DNA Repair Enzymes; Gene Expression Regulation; Humans; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome | 2016 |
Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
Topics: Adenosine; Eukaryota; Methylation; Nerve Tissue Proteins; RNA Processing, Post-Transcriptional; RNA Splicing; RNA Splicing Factors; RNA, Messenger; Transcriptome | 2016 |
Incidence of methylated histones H3K4 and H3K79 in cat germinal vesicles is regulated by specific nuclear factors at the acquisition of developmental competence during the folliculogenesis.
Topics: Adenosine; Animals; Cats; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Histones; Methylation; Methyltransferases; Oocytes; Ovarian Follicle; Sonication | 2016 |
Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA.
Topics: Adenosine; Alanine; Amino Acid Substitution; Anticodon; Catalytic Domain; Crystallography, X-Ray; Cysteine; Escherichia coli Proteins; Methylation; Methyltransferases; Nucleic Acid Conformation; Protein Structure, Tertiary; RNA, Bacterial; RNA, Transfer, Glu; S-Adenosylmethionine | 2016 |
Combined inhibition of EZH2 and histone deacetylases as a potential epigenetic therapy for non-small-cell lung cancer cells.
Topics: Acetylation; Adenosine; Animals; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin-Dependent Kinase Inhibitor p27; Drug Synergism; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; ErbB Receptors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Methylation; Mice; Mice, Inbred BALB C; Mutation; Phosphorylation; Polycomb Repressive Complex 2; Signal Transduction; Vorinostat; Xenograft Model Antitumor Assays | 2016 |
New Edges of RNA Adenosine Methylation Modifications.
Topics: Adenosine; Alternative Splicing; Animals; Humans; Methylation; Methyltransferases; RNA; RNA Splicing Factors; RNA, Messenger | 2016 |
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex.
Topics: Adenosine; Binding Sites; Biocatalysis; Catalytic Domain; Humans; Hydrogen Bonding; Ligands; Methylation; Methyltransferases; Models, Biological; Models, Molecular; Protein Structure, Quaternary; Protein Subunits; RNA; Structure-Activity Relationship | 2016 |
DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
Topics: Adenosine; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia, Myeloid, Acute; Lysine; Methylation; Methyltransferases; Mice, Inbred C57BL; Molecular Targeted Therapy; Mutation; Phenylurea Compounds; Rats; Time Factors; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2016 |
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Topics: Adenosine; Allosteric Regulation; Binding Sites; Catalytic Domain; HEK293 Cells; Humans; Methylation; Methyltransferases; Models, Molecular; Mutation; Protein Binding; Protein Conformation; RNA; S-Adenosylhomocysteine; S-Adenosylmethionine; Structure-Activity Relationship | 2016 |
ZNF217/ZFP217 Meets Chromatin and RNA.
Topics: Adenosine; Animals; Cadherins; Carcinogenesis; Chromatin; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Humans; Jumonji Domain-Containing Histone Demethylases; Methylation; Mice; Mouse Embryonic Stem Cells; RNA Processing, Post-Transcriptional; RNA, Messenger; Trans-Activators; Transcription, Genetic | 2016 |
YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex.
Topics: Adenosine; HEK293 Cells; HeLa Cells; Humans; Methylation; Polyadenylation; Protein Binding; Protein Domains; Receptors, CCR4; Recombinant Proteins; Ribonucleases; RNA Stability; RNA-Binding Proteins; RNA, Messenger; Transcription Factors | 2016 |
Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Animals; Breast Neoplasms; Cell Hypoxia; Female; Gene Expression Regulation, Neoplastic; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; MCF-7 Cells; Methylation; Mice; Mice, SCID; Nanog Homeobox Protein; Neoplastic Stem Cells; RNA, Messenger; RNA, Small Interfering; Trans-Activators; Xenograft Model Antitumor Assays | 2016 |
m(6)A RNA methylation promotes XIST-mediated transcriptional repression.
Topics: Adenosine; Animals; Cell Cycle Proteins; Cell Line; Embryonic Stem Cells; Female; Gene Silencing; HEK293 Cells; Humans; Male; Methylation; Methyltransferases; Mice; Nerve Tissue Proteins; Nuclear Proteins; RNA Splicing Factors; RNA-Binding Proteins; RNA, Long Noncoding; Transcription, Genetic | 2016 |
Rational Design of a Profluorescent Substrate for S-adenosylhomocysteine Hydrolase and its Applications in Bioimaging and Inhibitor Screening.
Topics: Adenosine; Adenosylhomocysteinase; Kinetics; Methylation | 2016 |
Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates.
Topics: Adenosine; Animals; Escherichia coli; HeLa Cells; Humans; Methylation; Mitochondria; RNA; RNA Processing, Post-Transcriptional; RNA, Bacterial; RNA, Mitochondrial; RNA, Ribosomal, 16S; tRNA Methyltransferases | 2016 |
ALKBH1-Mediated tRNA Demethylation Regulates Translation.
Topics: Adenosine; AlkB Homolog 1, Histone H2a Dioxygenase; Gene Expression Regulation; Glucose; HeLa Cells; Humans; Methylation; Polyribosomes; Protein Biosynthesis; RNA, Transfer | 2016 |
Spontaneous Emergence of S-Adenosylmethionine and the Evolution of Methylation.
Topics: Adenosine; Adenosine Triphosphate; Methylation; Methyltransferases; Nucleic Acid Conformation; S-Adenosylmethionine | 2017 |
Reversible methylation of m
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Endoribonucleases; Epigenesis, Genetic; Guanosine; Half-Life; HEK293 Cells; Humans; Male; Methylation; Mice; MicroRNAs; RNA Caps; RNA Stability; Substrate Specificity; Transcription Initiation Site; Transcriptome | 2017 |
Functional Dissection of the m6A RNA Modification.
Topics: Adenosine; Humans; Methylation; RNA | 2017 |
Emerging links between m
Topics: Adenosine; Animals; Humans; Methylation; Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger | 2017 |
Bypassing rRNA methylation by RsmA/Dim1during ribosome maturation in the hyperthermophilic archaeon Nanoarchaeum equitans.
Topics: Adenosine; Desulfurococcaceae; Escherichia coli; Methylation; Methyltransferases; Nanoarchaeota; Ribosome Subunits, Small, Archaeal; RNA, Ribosomal, 16S | 2017 |
NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation.
Topics: 3' Untranslated Regions; Adenosine; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation; HeLa Cells; Humans; Methylation; Methyltransferases; Oxidative Stress; Protein Biosynthesis | 2017 |
m
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Base Sequence; Brain Neoplasms; Carcinogenesis; Cell Differentiation; Cell Proliferation; Cell Self Renewal; Disease Progression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioblastoma; Humans; Meclofenamic Acid; Methylation; Methyltransferases; Mice; Neoplastic Stem Cells; RNA; RNA, Messenger | 2017 |
Detection and Quantification of N
Topics: Adenosine; Chromatography, Thin Layer; Epigenesis, Genetic; Hydrolysis; Isotope Labeling; Methylation; RNA, Messenger; Single-Strand Specific DNA and RNA Endonucleases; Transcriptome | 2017 |
Transcriptome-Wide Mapping of N
Topics: Adenosine; AlkB Enzymes; Epigenesis, Genetic; Epigenomics; Gene Library; Immunoprecipitation; Methylation; RNA, Messenger; Transcriptome | 2017 |
A fly view on the roles and mechanisms of the m
Topics: Adenosine; Adenosine Triphosphatases; Animals; Drosophila melanogaster; Gene Expression Regulation; Methylation; RNA Splicing; RNA, Messenger | 2017 |
Transcription Impacts the Efficiency of mRNA Translation via Co-transcriptional N6-adenosine Methylation.
Topics: Adenosine; Gene Expression Regulation; Humans; Methylation; Peptide Chain Initiation, Translational; Protein Biosynthesis; RNA Polymerase II; RNA Processing, Post-Transcriptional; RNA, Messenger; TATA Box; Transcription, Genetic | 2017 |
A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases.
Topics: Adenosine; Drug Evaluation, Preclinical; Enzyme Inhibitors; Histone-Lysine N-Methyltransferase; Humans; Methylation; Pyrrolidines; Small Molecule Libraries; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sulfonamides; Tetrahydroisoquinolines | 2017 |
Small methyltransferase RlmH assembles a composite active site to methylate a ribosomal pseudouridine.
Topics: Adenosine; Binding Sites; Catalytic Domain; Escherichia coli; Escherichia coli Proteins; Methylation; Methyltransferases; Models, Molecular; Mutation; Protein Binding; Protein Multimerization; Protein Structure, Secondary; Pseudouridine; RNA, Ribosomal, 23S; S-Adenosylmethionine; Substrate Specificity | 2017 |
Metabolic perturbation of epigenome by inhibiting S-adenosylhomocysteine hydrolase elicits senescence through DNA damage response in hepatoma cells.
Topics: Adenosine; Ataxia Telangiectasia Mutated Proteins; Carcinoma, Hepatocellular; Cell Proliferation; Cellular Senescence; Chromatin; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Epigenomics; Hep G2 Cells; Histones; Humans; Liver Neoplasms; Metabolic Networks and Pathways; Methylation; S-Adenosylhomocysteine; S-Adenosylmethionine; Tumor Suppressor Protein p53 | 2017 |
Identification of factors required for m
Topics: Adenosine; Arabidopsis; Arabidopsis Proteins; Conserved Sequence; Methylation; Methyltransferases; Plants, Genetically Modified; RNA, Messenger; Sequence Alignment; Ubiquitin-Protein Ligases | 2017 |
Label-free, direct localization and relative quantitation of the RNA nucleobase methylations m6A, m5C, m3U, and m5U by top-down mass spectrometry.
Topics: Adenosine; Base Sequence; Cytidine; Ions; Methylation; Molecular Structure; RNA; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Uridine | 2017 |
RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding.
Topics: Adenosine; Animals; Chromatin; Gene Expression Regulation; Methylation; Methyltransferases; Mice; Mouse Embryonic Stem Cells; Protein Binding; Ribonuclease III; RNA; RNA Stability; RNA-Binding Proteins; Transcription, Genetic | 2017 |
Position-dependent effects of regioisomeric methylated adenine and guanine ribonucleosides on translation.
Topics: Adenosine; Amino Acid Sequence; Base Pairing; Base Sequence; Codon; Escherichia coli; Guanosine; Methylation; Protein Biosynthesis; RNA, Messenger; Stereoisomerism; Triticum | 2017 |
PRMT1 expression is elevated in head and neck cancer and inhibition of protein arginine methylation by adenosine dialdehyde or PRMT1 knockdown downregulates proliferation and migration of oral cancer cells.
Topics: Adenosine; Aged; Apoptosis; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Male; Methylation; Middle Aged; Mouth Neoplasms; Prognosis; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Repressor Proteins; Tumor Cells, Cultured | 2017 |
m
Topics: Adenosine; Adoptive Transfer; Animals; Cell Differentiation; Cell Proliferation; Colitis; Disease Models, Animal; DNA-Binding Proteins; Female; Homeostasis; Interleukin-7; Male; Methylation; Methyltransferases; Mice; RNA Stability; RNA, Messenger; Signal Transduction; STAT5 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; T-Lymphocytes | 2017 |
The requirement of Mettl3-promoted
Topics: 5' Untranslated Regions; Adenosine; Animals; Cell Differentiation; Cell Line; Cell Proliferation; ELAV-Like Protein 1; G2 Phase; Gene Expression Regulation; Methylation; Methyltransferases; Mice; Muscle Development; Muscle, Skeletal; Myoblasts; MyoD Protein; Quinolines; RNA, Small Interfering; S Phase; Signal Transduction; Thiazoles; Thymidine | 2017 |
Region-specific RNA m
Topics: Adenosine; Animals; Cerebellum; Cerebral Cortex; Female; Fragile X Mental Retardation Protein; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Gene Regulatory Networks; Male; Methylation; Mice; Molecular Sequence Annotation; Neurons; Organ Specificity; RNA, Messenger; Signal Transduction; Synapses | 2017 |
Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- and RGG-dependent manner.
Topics: 5' Untranslated Regions; Adenosine; Amino Acid Sequence; Binding Sites; Methylation; Peptide Chain Initiation, Translational; Poly(A)-Binding Proteins; Polymers; Protein Binding; Protein Domains; RNA-Binding Proteins; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2018 |
A structural basis for the antibiotic resistance conferred by an N1-methylation of A1408 in 16S rRNA.
Topics: Adenosine; Aminoglycosides; Binding Sites; Drug Resistance, Bacterial; Gentamicins; Methylation; Models, Molecular; Mutation; Paromomycin; RNA, Bacterial; RNA, Ribosomal, 16S | 2017 |
RNA methylation regulates hematopoietic stem and progenitor cell development.
Topics: Adenosine; Hematopoietic Stem Cells; Methylation; Receptor, Notch1; RNA, Messenger; Signal Transduction | 2017 |
Human METTL16 is a
Topics: Adenosine; Base Pairing; Base Sequence; DNA, Complementary; Green Fluorescent Proteins; HEK293 Cells; HeLa Cells; Humans; Methylation; Methyltransferases; Oligopeptides; Recombinant Fusion Proteins; Ribonucleoproteins; RNA Precursors; RNA Splicing; RNA, Long Noncoding; RNA, Messenger; RNA, Small Nuclear | 2017 |
MeT-DB V2.0: elucidating context-specific functions of N6-methyl-adenosine methyltranscriptome.
Topics: Adenosine; Animals; Databases, Genetic; Humans; Methylation; Mice; MicroRNAs; RNA; RNA-Binding Proteins; RNA, Messenger; Transcriptome | 2018 |
Identifying the m
Topics: Adenosine; Antibodies; Chromatography, Affinity; Gene Library; High-Throughput Nucleotide Sequencing; Metabolome; Methylation; Quality Control; RNA | 2018 |
ALKBH10B Is an RNA
Topics: Adenosine; Arabidopsis; Arabidopsis Proteins; Demethylation; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Methylation; Mutation; Oxidoreductases, N-Demethylating; Protein Stability; RNA-Binding Proteins; RNA, Messenger; RNA, Plant; Substrate Specificity; Up-Regulation | 2017 |
Epitranscriptomics and Flowering: mRNA Methylation/Demethylation Regulates Flowering Time.
Topics: Adenosine; Arabidopsis; Demethylation; Methylation; RNA; RNA, Messenger | 2017 |
Our views of dynamic
Topics: Adenosine; Exons; Methylation; RNA; RNA Precursors; RNA, Messenger | 2018 |
Pre-mRNA processing includes
Topics: Adenosine; Animals; Embryonic Stem Cells; Epigenesis, Genetic; Exons; Female; HeLa Cells; Humans; Methylation; Methyltransferases; Mice; RNA Precursors; RNA Splicing; RNA Stability; RNA, Messenger | 2018 |
Adenosine-to-Inosine Editing of MicroRNA-487b Alters Target Gene Selection After Ischemia and Promotes Neovascularization.
Topics: Adenosine; Adenosine Deaminase; Animals; Base Sequence; Chromosomal Proteins, Non-Histone; Humans; Inosine; Ischemia; Methylation; Mice; Mice, Inbred C57BL; MicroRNAs; Muscle, Skeletal; Neovascularization, Physiologic; RNA Editing; RNA Interference; RNA-Binding Proteins; RNA, Small Interfering; Up-Regulation | 2018 |
m
Topics: Adenosine; Animals; Autoimmune Diseases; CD4-Positive T-Lymphocytes; Cell Proliferation; Gene Expression Regulation; Male; Methylation; Methyltransferases; Mice; Mice, Knockout; Sequence Analysis, RNA; T-Lymphocytes, Regulatory | 2018 |
RNA methylation regulates hematopoietic stem/progenitor cell specification.
Topics: Adenosine; Animals; Cell Differentiation; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Hematopoietic Stem Cells; Humans; Methylation; Methyltransferases; Receptor, Notch1; RNA-Binding Proteins; RNA, Messenger; Zebrafish; Zebrafish Proteins | 2018 |
Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication.
Topics: A549 Cells; Adenosine; Animals; Cells, Cultured; Chlorocebus aethiops; Gene Expression Regulation, Viral; Genes, Viral; HEK293 Cells; Humans; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Viral; Simian virus 40; Vero Cells; Viral Structural Proteins; Virus Replication | 2018 |
DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice.
Topics: Adenosine; Amino Acid Motifs; Animals; Calpain; Disease Models, Animal; Epigenesis, Genetic; Female; Histones; Humans; Lysine; Male; Methylation; Mice; Mice, Inbred ICR; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Retina; Retinal Degeneration | 2018 |
Zc3h13 Regulates Nuclear RNA m
Topics: 3' Untranslated Regions; Active Transport, Cell Nucleus; Adenosine; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Differentiation; Cell Nucleus; Cell Proliferation; Cell Self Renewal; DNA-Binding Proteins; Gene Expression Regulation, Developmental; HEK293 Cells; Humans; Methylation; Mice; Mouse Embryonic Stem Cells; Nuclear Proteins; RNA Processing, Post-Transcriptional; RNA Splicing Factors; RNA Stability; RNA-Binding Proteins; RNA, Messenger; Signal Transduction; Ubiquitin-Protein Ligases | 2018 |
Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis.
Topics: Adenosine; Animals; Cells, Cultured; Collagen Type I; Dialysis Solutions; Epithelium; Gene Expression Regulation; Glucose; Histone Code; Histone-Lysine N-Methyltransferase; Humans; Male; Methylation; Mice; Mice, Inbred C57BL; Nitrogen; Omentum; Peritoneal Dialysis; Peritoneal Fibrosis; Promoter Regions, Genetic; Pyruvaldehyde; Transforming Growth Factor beta1 | 2018 |
Existence of Diverse Modifications in Small-RNA Species Composed of 16-28 Nucleotides.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Chromatography, Liquid; Humans; Methylation; Nucleosides; Nucleotides; RNA; RNA, Messenger; RNA, Transfer; Tandem Mass Spectrometry | 2018 |
Glycogen synthase kinase-3 (GSK-3) activity regulates mRNA methylation in mouse embryonic stem cells.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Cells, Cultured; Glycogen Synthase Kinase 3; Methylation; Mice; Mice, Knockout; Mouse Embryonic Stem Cells; Phosphorylation; RNA, Messenger; Ubiquitination | 2018 |
miCLIP-MaPseq, a Substrate Identification Approach for Radical SAM RNA Methylating Enzymes.
Topics: Adenosine; Cysteine; Escherichia coli; Escherichia coli Proteins; Immunoprecipitation; Methylation; Methyltransferases; Mutation; RNA; S-Adenosylmethionine; Sequence Analysis, RNA; Substrate Specificity | 2018 |
RNA m
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Animals; Cell Hypoxia; Cell Line; Cerebellum; Female; HEK293 Cells; Humans; Male; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA | 2018 |
METTL3-mediated m6A modification is required for cerebellar development.
Topics: Adenosine; Alternative Splicing; Animals; Apoptosis; Cells, Cultured; Cerebellum; Developmental Disabilities; Gene Expression Regulation; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Nervous System Malformations; RNA Stability; RNA, Messenger | 2018 |
Modification of N6-methyladenosine RNA methylation on heat shock protein expression.
Topics: Adenosine; Gene Expression; Gene Expression Regulation; Heat-Shock Proteins; Heat-Shock Response; Hep G2 Cells; Humans; Methylation; RNA, Messenger | 2018 |
Genome-wide identification of m
Topics: Adenosine; Bone Density; Femur Neck; Gene Expression Regulation; Genome-Wide Association Study; Humans; Lumbar Vertebrae; Methylation; Polymorphism, Single Nucleotide; Quantitative Trait Loci; RNA, Messenger | 2018 |
Epitranscriptomes in the Adult Mammalian Brain: Dynamic Changes Regulate Behavior.
Topics: Adenosine; Animals; Brain; Methylation; Methyltransferases; RNA, Messenger | 2018 |
Quantification of methylation efficiency at a specific N
Topics: Adenosine; DNA Probes; Escherichia coli; Methylation; Nucleic Acid Hybridization; RNA, Ribosomal, 23S; Transition Temperature | 2018 |
Perspectives on topology of the human m
Topics: Adenosine; Humans; Membrane Proteins; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription Initiation Site; Transcriptome | 2018 |
m
Topics: Adenosine; Animals; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Mechanistic Target of Rapamycin Complex 2; Methylation; Methyltransferases; Mice, Nude; Mutation; Phosphoprotein Phosphatases; Proto-Oncogene Proteins c-akt; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Neoplasm; Signal Transduction; Time Factors; Tumor Burden | 2018 |
The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure.
Topics: Adenosine; Amino Acid Motifs; Cloning, Molecular; Ebolavirus; Escherichia coli; Gene Expression; Gene Expression Regulation, Viral; Genetic Vectors; Guanosine; Methylation; Methyltransferases; Protein Domains; Recombinant Proteins; RNA Caps; RNA, Viral; Substrate Specificity; Viral Nonstructural Proteins; Virus Replication | 2018 |
Differential m
Topics: 3T3-L1 Cells; Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Cell Nucleus; Cytoplasm; Demethylation; Gene Expression; HEK293 Cells; HeLa Cells; Humans; Methylation; Mice; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Small Nuclear; RNA, Transfer | 2018 |
Structural Basis for Regulation of METTL16, an S-Adenosylmethionine Homeostasis Factor.
Topics: 3' Untranslated Regions; Adenosine; Binding Sites; HEK293 Cells; Homeostasis; Humans; Methionine Adenosyltransferase; Methylation; Methyltransferases; RNA; RNA, Messenger; RNA, Small Nuclear; S-Adenosylmethionine | 2018 |
Structural and Energetic Effects of O2'-Ribose Methylation of Protonated Purine Nucleosides.
Topics: Adenosine; Guanosine; Methylation; Models, Molecular; Molecular Conformation; Ribose; Tandem Mass Spectrometry; Thermodynamics | 2018 |
MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m
Topics: Adenosine; Adipocytes; Adipogenesis; Animals; Gene Expression Profiling; Gene Expression Regulation, Developmental; Male; Methylation; Mitochondrial Membrane Transport Proteins; Muscle Development; Muscle, Skeletal; RNA Stability; RNA-Binding Proteins; RNA, Messenger; Swine | 2019 |
N
Topics: Adenosine; Arabidopsis; Base Sequence; Conserved Sequence; Exoribonucleases; Methylation; Open Reading Frames; Plant Proteins; Ribonucleotides; RNA Stability; RNA, Messenger; Sodium Chloride; Stress, Physiological; Transcriptome | 2018 |
Determination of enrichment factors for modified RNA in MeRIP experiments.
Topics: Adenosine; Adenosine Triphosphate; Cell-Free System; Chromatography, Thin Layer; DNA-Directed RNA Polymerases; Escherichia coli; Humans; Immunoglobulin G; Immunoprecipitation; Isotope Labeling; Methylation; Models, Molecular; Phosphorus Radioisotopes; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; RNA, Messenger; Viral Proteins | 2019 |
BERMP: a cross-species classifier for predicting m
Topics: Adenosine; Algorithms; Computational Biology; Deep Learning; Machine Learning; Methylation; RNA | 2018 |
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m
Topics: Adenosine; Animals; ARNTL Transcription Factors; Cell Proliferation; Circadian Clocks; Gene Deletion; Hep G2 Cells; Humans; Lipid Metabolism; Liver; Methylation; Methyltransferases; Mice, Knockout; Models, Biological; PPAR alpha; Reactive Oxygen Species; RNA Stability; RNA-Binding Proteins; RNA, Messenger; Time Factors | 2018 |
Selective targeting of histone modification fails to prevent graft versus host disease after hematopoietic cell transplantation.
Topics: Adenosine; Animals; Benzamides; Biphenyl Compounds; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Histone Code; Histones; Humans; Indoles; Methylation; Mice; Morpholines; Pyridones; T-Lymphocytes | 2018 |
N
Topics: Adenosine; Animals; Cell Proliferation; Humans; Liver Neoplasms; Male; Methylation; Methyltransferases; Mice, Inbred BALB C; Protein Biosynthesis; RNA, Ribosomal, 28S; Xenograft Model Antitumor Assays | 2019 |
N6-methyladenosine RNA methylation is involved in virulence of the rice blast fungus Pyricularia oryzae (syn. Magnaporthe oryzae).
Topics: Adenosine; Genes, Fungal; Magnaporthe; Methylation; Oryza; RNA, Fungal; Virulence | 2019 |
High-Resolution Mapping of N
Topics: Adenosine; HeLa Cells; High-Throughput Nucleotide Sequencing; Humans; Immunoprecipitation; Methylation; RNA | 2019 |
Decoding the Atlas of RNA Modifications from Epitranscriptome Sequencing Data.
Topics: 5-Methylcytosine; Adenosine; Binding Sites; Computational Biology; Databases, Nucleic Acid; High-Throughput Nucleotide Sequencing; Humans; Methylation; MicroRNAs; Polymorphism, Single Nucleotide; RNA Processing, Post-Transcriptional; Software; Transcriptome; User-Computer Interface; Web Browser | 2019 |
Profiling of N
Topics: Adenosine; Cell Line; Host-Pathogen Interactions; Humans; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Viral; Zika Virus; Zika Virus Infection | 2019 |
The m
Topics: Adenosine; Gene Expression Regulation; Humans; Methylation; Methyltransferases; RNA Processing, Post-Transcriptional; RNA, Messenger | 2019 |
m
Topics: Adenosine; Animals; Cell Line, Tumor; Cytomegalovirus; Disease Models, Animal; Female; Fibroblasts; Herpesviridae Infections; Host-Pathogen Interactions; Humans; Immunity, Innate; Influenza A Virus, H1N1 Subtype; Influenza, Human; Interferon Type I; Male; Methylation; Methyltransferases; Mice; Mice, Inbred ICR; Mice, Knockout; Muromegalovirus; RNA-Binding Proteins; RNA, Messenger | 2019 |
Mettl3 Deficiency Sustains Long-Chain Fatty Acid Absorption through Suppressing Traf6-Dependent Inflammation Response.
Topics: Adenosine; Animals; Cell Line; Fatty Acids; Gene Silencing; Inflammation; Intestinal Absorption; Methylation; Methyltransferases; NF-kappa B; RNA, Messenger; Signal Transduction; Swine; TNF Receptor-Associated Factor 6 | 2019 |
DeepM6ASeq: prediction and characterization of m6A-containing sequences using deep learning.
Topics: Adenosine; Alternative Splicing; Animals; Brain; Carcinoma, Hepatocellular; Computational Biology; Deep Learning; Embryonic Stem Cells; Humans; Liver Neoplasms; Methylation; Mice; RNA; Sequence Analysis, RNA; Zebrafish | 2018 |
Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.
Topics: Adenocarcinoma; Adenosine; Animals; Bone Marrow Cells; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Culture Media, Conditioned; Dendritic Cells; Epigenesis, Genetic; Forkhead Box Protein M1; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Methylation; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Pancreatic Neoplasms; Phenylurea Compounds; Signal Transduction; Thiostrepton; Wnt-5a Protein | 2019 |
Epitranscriptomics: Correlation of N6-methyladenosine RNA methylation and pathway dysregulation in the hippocampus of HIV transgenic rats.
Topics: Adenosine; AIDS Dementia Complex; Animals; Disease Models, Animal; Epigenesis, Genetic; Gene Expression Regulation; Hippocampus; HIV-1; Host-Pathogen Interactions; Humans; Male; Methylation; Rats; Rats, Sprague-Dawley; Rats, Transgenic; RNA Splicing; RNA, Messenger; RNA, Viral; Sequence Analysis, RNA; Transcriptome | 2019 |
CAPAM: The mRNA Cap Adenosine N6-Methyltransferase.
Topics: Adenosine; Animals; Humans; Methylation; Methyltransferases; RNA Caps; RNA, Messenger | 2019 |
DNA triplex-based fluorescence turn-on sensors for adenosine using a fluorescent molecular rotor 5-(3-methylbenzofuran-2-yl) deoxyuridine.
Topics: Adenosine; Base Sequence; Benzofurans; Biosensing Techniques; Deoxyuridine; DNA; Fluorescent Dyes; Methylation; Molecular Docking Simulation; Molecular Dynamics Simulation; Spectrometry, Fluorescence | 2019 |
The role of N
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Animals; Heat-Shock Proteins; Heat-Shock Response; Methylation; Methyltransferases; Nuclear Proteins; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; Sheep | 2019 |
Anti-tumour immunity controlled through mRNA m
Topics: Adenosine; Animals; Antigen Presentation; Antigens, Neoplasm; B7-H1 Antigen; Binding Sites; Cathepsins; CD8-Positive T-Lymphocytes; Cross-Priming; Dendritic Cells; Female; Humans; Methylation; Mice; Mice, Inbred C57BL; Neoplasms; Protein Biosynthesis; Proteins; RNA-Binding Proteins; RNA, Messenger; Transcriptome | 2019 |
FTO controls reversible m
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Alternative Splicing; Animals; HEK293 Cells; Humans; Male; Methylation; Mice; Mice, Knockout; RNA Precursors; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Small Nuclear | 2019 |
m
Topics: 3' Untranslated Regions; 3T3-L1 Cells; Adenosine; Animals; Cell Differentiation; Embryonic Stem Cells; Induced Pluripotent Stem Cells; Janus Kinase 2; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Methylation; Methyltransferases; Mice; RNA Stability; RNA-Binding Proteins; RNA, Small Interfering; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Swine | 2019 |
Dynamic m
Topics: Adenosine; Animals; Antigens, Neoplasm; Carcinogenesis; Carcinogens; Cell Adhesion Molecules; Cells, Cultured; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Methylation; Methyltransferases; Mice; Mice, Inbred NOD; Mice, SCID; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; Signal Transduction | 2019 |
Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death.
Topics: Adenosine; Animals; Apoptosis; Brain; Cell Death; Disease Models, Animal; Dopaminergic Neurons; Down-Regulation; Epigenesis, Genetic; Male; Methylation; Oxidopamine; Parkinson Disease; PC12 Cells; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sympatholytics | 2019 |
A novel RT-QPCR-based assay for the relative quantification of residue specific m6A RNA methylation.
Topics: 3' Untranslated Regions; Adenosine; Caco-2 Cells; Deoxyribonuclease BamHI; Humans; Methylation; Nucleotide Motifs; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling 3 Protein | 2019 |
Histone H3 trimethylation at lysine 36 guides m
Topics: Adenosine; Animals; Cell Differentiation; Cell Line; Embryonic Stem Cells; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice; RNA Polymerase II; RNA, Messenger; Transcription Elongation, Genetic; Transcription, Genetic; Transcriptome | 2019 |
Changes of N6-methyladenosine modulators promote breast cancer progression.
Topics: Adenosine; Adult; Breast; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Datasets as Topic; Disease Progression; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Methylation; Methyltransferases; Middle Aged; Mutation; Oxidoreductases, N-Demethylating; Prognosis; RNA, Messenger | 2019 |
Transcriptome-wide analysis of N6-methyladenosine uncovers its regulatory role in gene expression in the lepidopteran Bombyx mori.
Topics: Adenosine; Alternative Splicing; Animals; Bombyx; Cell Line; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation; Larva; Methylation; Methyltransferases; RNA, Messenger | 2019 |
m
Topics: Adenosine; Animals; Cardiomyopathy, Dilated; Cell Enlargement; Cell Proliferation; Cell Size; Cells, Cultured; Cohort Studies; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Male; Methylation; Methyltransferases; Mice; Myocytes, Cardiac; Protein Biosynthesis; Rats; RNA, Messenger | 2019 |
WHISTLE: a high-accuracy map of the human N6-methyladenosine (m6A) epitranscriptome predicted using a machine learning approach.
Topics: Adenosine; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Humans; Internet; Machine Learning; Methylation; Protein Interaction Maps; RNA; Sequence Analysis, RNA; Transcriptome | 2019 |
RBM15 Modulates the Function of Chromatin Remodeling Factor BAF155 Through RNA Methylation in Developing Cortex.
Topics: Adenosine; Adherens Junctions; Animals; Cell Line; Cerebral Cortex; Chromatin Assembly and Disassembly; Humans; Methylation; Methyltransferases; Mice; Models, Biological; Neuroglia; RNA; RNA-Binding Proteins; RNA, Messenger; Transcription Factors | 2019 |
The RNA N
Topics: Adenosine; Enhancer Elements, Genetic; Epigenomics; Fetal Development; Fetus; Gene Expression Profiling; Gene Expression Regulation; Humans; Methylation; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; RNA, Long Noncoding; Transcriptome | 2019 |
Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.
Topics: 3T3-L1 Cells; Adenosine; Adipogenesis; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; HEK293 Cells; Humans; Methylation; Mice; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; Trans-Activators; Transcriptional Activation; Transcriptome | 2019 |
m6Acomet: large-scale functional prediction of individual m
Topics: Adenosine; Epigenesis, Genetic; Humans; Methylation; RNA Processing, Post-Transcriptional; Software | 2019 |
RNA m
Topics: Adenosine; Animals; Cell Line, Tumor; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Kaplan-Meier Estimate; Liver; Liver Neoplasms; Methylation; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; RNA; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; Snail Family Transcription Factors; Tissue Array Analysis; Up-Regulation; Xenograft Model Antitumor Assays | 2019 |
Stage-specific requirement for Mettl3-dependent m
Topics: Adenosine; Animals; Bone Marrow Cells; Cell Differentiation; Gene Expression Regulation, Developmental; Hematopoietic Stem Cells; Methylation; Methyltransferases; Mice; Proto-Oncogene Proteins c-myc; RNA, Messenger; Sequence Analysis, RNA | 2019 |
The subunit of RNA N6-methyladenosine methyltransferase OsFIP regulates early degeneration of microspores in rice.
Topics: Adenosine; Amino Acid Motifs; Arabidopsis; Gametogenesis, Plant; Gene Expression Regulation, Plant; Loss of Function Mutation; Meiotic Prophase I; Methylation; Methyltransferases; Nucleoside-Triphosphatase; Oryza; Plant Proteins; Pollen; Protein Subunits; RNA, Plant; Species Specificity | 2019 |
Profiling of RNA N6-methyladenosine methylation during follicle selection in chicken ovary.
Topics: Adenosine; Animals; Chickens; Female; Gene Expression Profiling; Methylation; Ovarian Follicle; RNA | 2019 |
The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1.
Topics: Adenosine; Adolescent; Bone Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Child; Disease Progression; Humans; Lymphoid Enhancer-Binding Factor 1; Methylation; Methyltransferases; Osteosarcoma; RNA Interference; RNA, Messenger; Wnt Signaling Pathway | 2019 |
Deciphering the "m
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Antibodies; Chromatography, High Pressure Liquid; Embryoid Bodies; Embryonic Stem Cells; Endoribonucleases; Humans; Meiosis; Methylation; Mice; Nucleotide Motifs; RNA, Messenger; Saccharomyces cerevisiae; Sequence Analysis, RNA; Tandem Mass Spectrometry | 2019 |
Inhibition of juvenile hormone synthesis in mosquitoes by the methylation inhibitor 3-deazaneplanocin A (DZNep).
Topics: Adenosine; Aedes; Animals; Female; Insect Proteins; Juvenile Hormones; Methylation; Methyltransferases | 2019 |
Identification of the m
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Humans; Methylation; Methyltransferases; Nuclear Proteins; Protein Biosynthesis; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription Initiation Site; Transcriptome | 2019 |
PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Nuclear Proteins; Phosphorylation; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcription, Genetic; Transcriptome | 2019 |
The m6A demethylase ALKBH5 controls trophoblast invasion at the maternal-fetal interface by regulating the stability of
Topics: Abortion, Habitual; Adenosine; Adult; AlkB Homolog 5, RNA Demethylase; Cell Movement; Cysteine-Rich Protein 61; Female; Humans; Maternal-Fetal Exchange; Methylation; Pregnancy; RNA Stability; RNA, Messenger; Trophoblasts; Up-Regulation; Young Adult | 2019 |
m
Topics: Adenosine; Animals; Biological Transport; Cell Compartmentation; Cell Line; Cytoplasmic Granules; Humans; Methylation; Methyltransferases; Mice; Phase Transition; RNA-Binding Proteins; RNA, Messenger; Stress, Physiological | 2019 |
Epitranscriptomic mechanisms of N6-methyladenosine methylation regulating mammalian hypertension development by determined spontaneously hypertensive rats pericytes.
Topics: 3' Untranslated Regions; 5' Untranslated Regions; Adenosine; Animals; Disease Models, Animal; Epigenomics; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; High-Throughput Nucleotide Sequencing; Hypertension; Male; Methylation; Organ Specificity; Pericytes; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2019 |
m
Topics: 3' Untranslated Regions; Adenosine; Gene Expression Regulation, Fungal; Meiosis; Methylation; Repressor Proteins; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2019 |
The
Topics: Adenosine; Animals; Anti-Inflammatory Agents; Gene Expression Regulation; Macrophage Activation; Macrophages; Male; Methylation; Methyltransferases; Mice, Inbred C57BL; RNA, Messenger; STAT1 Transcription Factor | 2019 |
Non-peptidyl small molecule, adenosine, 5'-Se-methyl-5'-seleno-, 2',3'-diacetate, activates insulin receptor and attenuates hyperglycemia in type 2 diabetic Lepr
Topics: Adenosine; Animals; Diabetes Mellitus, Type 2; Glucose; Hep G2 Cells; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Methylation; Mice; Mice, Inbred C57BL; Organoselenium Compounds; Receptor, Insulin | 2020 |
Transcriptome-wide dynamics of extensive m
Topics: Adenosine; CRISPR-Cas Systems; Erythrocytes; Gene Expression Regulation; Gene Knockdown Techniques; Genes, Protozoan; Humans; Life Cycle Stages; Malaria, Falciparum; Methylation; Methyltransferases; Plasmodium falciparum; Protozoan Proteins; RNA, Messenger; Transcriptome | 2019 |
RNA methylomes reveal the m
Topics: Adenosine; DNA Methylation; Endoplasmic Reticulum; Fruit; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Methylation; Mutation; Nucleotide Motifs; Plant Proteins; RNA Stability; RNA, Messenger; Solanum lycopersicum | 2019 |
HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N
Topics: 5' Untranslated Regions; Adenosine; Cell Line, Tumor; Genes, Reporter; Heat-Shock Proteins; HSP40 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Methylation; Proteomics; RNA, Messenger; Triazoles | 2019 |
METTL3 inhibits hepatic insulin sensitivity via N6-methyladenosine modification of Fasn mRNA and promoting fatty acid metabolism.
Topics: Adenosine; Animals; Dependovirus; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acid Synthase, Type I; Fatty Acids; Gene Deletion; Glucose; Hepatocytes; Homeostasis; Humans; Insulin Resistance; Liver; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Obesity; RNA, Messenger | 2019 |
Molecular characterization and clinical relevance of m
Topics: Adenosine; Computational Biology; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genetic Variation; Humans; Methylation; Neoplasms; Prognosis; Signal Transduction | 2019 |
Genetic variants in m6A modification genes are associated with colorectal cancer risk.
Topics: Adenosine; Aged; Case-Control Studies; Cell Line, Tumor; Colorectal Neoplasms; Endonucleases; Female; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Male; Methylation; Middle Aged; Polymorphism, Single Nucleotide; RNA Processing, Post-Transcriptional; RNA, Messenger | 2020 |
m6A RNA Methylation Controls Proliferation of Human Glioma Cells by Influencing Cell Apoptosis.
Topics: Adenosine; Apoptosis; Brain Neoplasms; Cell Line; Cell Movement; Cell Proliferation; Glioma; Humans; Methylation; Methyltransferases | 2019 |
Implications of m6A modification in autoimmune disorders.
Topics: Adenosine; Autoimmune Diseases; Humans; Immune Tolerance; Methylation; Methyltransferases; RNA, Circular; T-Lymphocytes, Regulatory | 2020 |
Integrated analysis of transcriptome-wide m
Topics: Adenosine; Bone Neoplasms; Cell Line, Tumor; Epigenesis, Genetic; Epigenome; Gene Expression Profiling; Humans; Methylation; Neoplastic Stem Cells; Osteosarcoma; RNA; Transcriptome | 2019 |
Structure and regulation of ZCCHC4 in m
Topics: Adenosine; Amino Acid Sequence; Binding Sites; Catalytic Domain; Crystallography, X-Ray; Humans; Methylation; Methyltransferases; Models, Molecular; Protein Binding; Protein Conformation; Protein Domains; RNA, Ribosomal, 28S; Substrate Specificity; Zinc Fingers | 2019 |
m
Topics: Adenosine; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Eye Neoplasms; Gene Expression Profiling; Humans; Melanoma; Methylation; Mitochondrial Proteins; Prognosis; RNA Processing, Post-Transcriptional; RNA, Messenger | 2019 |
Optimizing cardiac ischemic preconditioning and postconditioning via epitranscriptional regulation.
Topics: Adenosine; Gene Expression Regulation; Heme Oxygenase-1; Humans; Ischemic Postconditioning; Ischemic Preconditioning, Myocardial; Methylation; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type III; RNA; RNA, Messenger; Signal Transduction; Superoxide Dismutase-1; Transcriptome | 2020 |
YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma.
Topics: Adenosine; Animals; Carcinoma, Hepatocellular; Epigenesis, Genetic; Humans; Inflammation; Liver Neoplasms; Methylation; Mice; Models, Biological; Neovascularization, Pathologic; RNA-Binding Proteins; RNA, Messenger; Transcriptome | 2019 |
Occurrence and Functions of m
Topics: Adenosine; Arabidopsis; Gene Expression Regulation, Plant; Methylation; RNA, Messenger; RNA, Plant | 2020 |
m
Topics: Adenosine; Animals; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation; HEK293 Cells; Humans; Methylation; Mice; Open Reading Frames; Protein Biosynthesis; RNA Helicases; RNA, Messenger | 2019 |
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA.
Topics: Adenosine; Catalysis; Humans; Methylation; Methyltransferases; Protein Binding; RNA, Messenger; RNA, Ribosomal, 28S | 2020 |
m6A RNA methylation regulators can contribute to malignant progression and impact the prognosis of bladder cancer.
Topics: Adenosine; Biomarkers, Tumor; Disease-Free Survival; Female; Humans; Male; Methylation; RNA, Neoplasm; Survival Rate; Urinary Bladder Neoplasms | 2019 |
The Prognostic Value of m6A RNA Methylation Regulators in Colon Adenocarcinoma.
Topics: Adenocarcinoma; Adenosine; Adenosine Triphosphatases; Algorithms; Cluster Analysis; Colon; Colonic Neoplasms; Databases, Genetic; Gene Expression Profiling; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Methylation; Methyltransferases; Multivariate Analysis; Prognosis; RNA; RNA Helicases; RNA-Binding Proteins; tRNA Methyltransferases | 2019 |
Immune signature of T follicular helper cells predicts clinical prognostic and therapeutic impact in lung squamous cell carcinoma.
Topics: Adenosine; Aged; AlkB Homolog 5, RNA Demethylase; Antineoplastic Agents, Immunological; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Datasets as Topic; Female; Gene Expression Regulation, Neoplastic; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Male; Methylation; Methyltransferases; Middle Aged; Prognosis; RNA-Binding Proteins; RNA-Seq; T Follicular Helper Cells; Transcriptome | 2020 |
m
Topics: Adenosine; Cell Line, Tumor; Cell Self Renewal; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Immunohistochemistry; Methylation; Models, Biological; Neoplastic Stem Cells; Polycomb Repressive Complex 1; Promoter Regions, Genetic; Protein Binding; Receptors, G-Protein-Coupled | 2019 |
KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3.
Topics: Adenosine; Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; GATA3 Transcription Factor; Humans; Liver Neoplasms; Methylation; Mice; Models, Biological; Neoplasm Metastasis; Prognosis; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Antisense; RNA, Long Noncoding; Xenograft Model Antitumor Assays | 2019 |
Mono-(2-Ethylhexyl)phthalate Regulates Cholesterol Efflux via MicroRNAs Regulated m
Topics: Adenosine; Animals; Cells, Cultured; Cholesterol; Diethylhexyl Phthalate; Methylation; Mice; MicroRNAs; RAW 264.7 Cells; RNA | 2020 |
Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer.
Topics: Adenosine; Animals; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; HCT116 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Male; Methylation; Mice; Mice, Nude; Neoplasm Transplantation; Phenylurea Compounds; Prognosis; Proto-Oncogene Proteins c-myc | 2019 |
m
Topics: Adenosine; Animals; Cell Adhesion Molecules; Cell Count; Cell Differentiation; Cell Lineage; Cells, Cultured; Female; Male; Methylation; Methyltransferases; Mice; Mice, Transgenic; Myelin Sheath; Nerve Growth Factors; Oligodendrocyte Precursor Cells; Oligodendroglia; RNA, Messenger | 2020 |
Integrative network analysis identifies cell-specific trans regulators of m6A.
Topics: Adenosine; Cell Cycle Proteins; Cell Lineage; Cell Survival; Gene Expression Regulation; Gene Knockdown Techniques; Hep G2 Cells; Humans; Methylation; RNA; RNA Processing, Post-Transcriptional; RNA-Binding Proteins | 2020 |
Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m
Topics: Adenosine; Arabidopsis; Gene Expression Profiling; Methylation; Nanopores; Poly A; RNA Caps; RNA Processing, Post-Transcriptional; RNA Splicing; RNA, Messenger; RNA, Plant; RNA, Untranslated; Sequence Analysis, RNA | 2020 |
Characterization of METTL16 as a cytoplasmic RNA binding protein.
Topics: Adenosine; Cytoplasm; HEK293 Cells; HeLa Cells; Humans; Methionine Adenosyltransferase; Methylation; Methyltransferases; Nuclear Proteins; RNA Splicing; RNA Stability; RNA-Binding Proteins; RNA, Long Noncoding; RNA, Messenger; RNA, Small Nuclear; S-Adenosylmethionine | 2020 |
Identification of three m6A-related mRNAs signature and risk score for the prognostication of hepatocellular carcinoma.
Topics: Adenosine; Biomarkers, Tumor; Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line, Tumor; Datasets as Topic; Disease Progression; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Methylation; Methyltransferases; Nomograms; Risk Factors; RNA, Messenger; ROC Curve; Suppressor of Cytokine Signaling Proteins; Transaminases | 2020 |
Topics: Adenosine; Animals; Chromatin; Embryonic Stem Cells; Enhancer Elements, Genetic; Methylation; Methyltransferases; Mice; Mice, Knockout; Promoter Regions, Genetic; RNA, Messenger; RNA, Nuclear; Transcription, Genetic | 2020 |
Epitranscriptomic profiling of N6-methyladenosine-related RNA methylation in rat cerebral cortex following traumatic brain injury.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Brain Injuries, Traumatic; Cerebral Cortex; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation; Gene Ontology; Immunoprecipitation; Male; Methylation; Methyltransferases; Nerve Tissue Proteins; Rats; Rats, Sprague-Dawley; RNA Processing, Post-Transcriptional | 2020 |
RNA m
Topics: Adenosine; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Down-Regulation; Epigenesis, Genetic; Gene Knockdown Techniques; Humans; Melanoma; Methylation; Methyltransferases; Neoplasm Invasiveness; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; RNA, Messenger; RNA, Neoplasm; Up-Regulation; Uveal Neoplasms | 2020 |
Long-range single-molecule mapping of chromatin accessibility in eukaryotes.
Topics: Adenosine; Cell Line; Chromatin; Chromatin Immunoprecipitation; CpG Islands; DNA Fragmentation; DNA Methylation; High-Throughput Nucleotide Sequencing; Humans; Methylation; Methyltransferases; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Saccharomyces cerevisiae | 2020 |
m
Topics: Adenosine; Adult; Aged; Biomarkers, Tumor; Disease Progression; Disease-Free Survival; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Methylation; Middle Aged; Prognosis; Proportional Hazards Models; Protein Interaction Maps; Rectal Neoplasms; RNA; RNA Helicases; RNA-Binding Proteins; Transcriptome | 2020 |
Machine learning of reverse transcription signatures of variegated polymerases allows mapping and discrimination of methylated purines in limited transcriptomes.
Topics: Adenosine; Guanosine; Machine Learning; Methylation; Oligoribonucleotides; Reverse Transcription; RNA-Directed DNA Polymerase; Transcriptome | 2020 |
GNAS promotes inflammation-related hepatocellular carcinoma progression by promoting STAT3 activation.
Topics: Adenosine; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromogranins; Disease Progression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; GTP-Binding Protein alpha Subunits, Gs; Humans; Inflammation; Interleukin-6; Lipopolysaccharides; Liver Neoplasms; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; RNA Interference; RNA, Long Noncoding; Signal Transduction; STAT3 Transcription Factor; Xenograft Model Antitumor Assays | 2020 |
N 1-methyladenosine (m1A) RNA modification: the key to ribosome control.
Topics: Adenosine; Animals; Caenorhabditis elegans; Humans; Methylation; Methyltransferases; Mice; Ribosomes; RNA, Ribosomal; RNA, Transfer | 2020 |
Impact of the gut microbiota on the m
Topics: Adenosine; Animals; Bacteria; Cecum; Female; Gastrointestinal Microbiome; Liver; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; RNA, Messenger; Transcriptome | 2020 |
MoAIMS: efficient software for detection of enriched regions of MeRIP-Seq.
Topics: Adenosine; Gene Expression Profiling; Humans; Immunoprecipitation; Methylation; RNA; Sequence Analysis, RNA; Software | 2020 |
A five-gene signature derived from m6A regulators to improve prognosis prediction of neuroblastoma.
Topics: Adenosine; Antineoplastic Agents; Biomarkers, Tumor; Computational Biology; Datasets as Topic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Infant; Kaplan-Meier Estimate; Male; Methylation; Molecular Targeted Therapy; Neuroblastoma; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Survival Rate; Transcriptome | 2020 |
microRNA-670 modulates Igf2bp1 expression to regulate RNA methylation in parthenogenetic mouse embryonic development.
Topics: Adenosine; Animals; Apoptosis; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Developmental; Methylation; Mice; MicroRNAs; Parthenogenesis; RNA; RNA-Binding Proteins | 2020 |
Coordination of mRNA and tRNA methylations by TRMT10A.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Gene Expression Regulation; HEK293 Cells; High-Throughput Nucleotide Sequencing; Humans; Methylation; Methyltransferases; RNA-Binding Proteins; RNA, Messenger; RNA, Transfer; tRNA Methyltransferases | 2020 |
LNCAROD is stabilized by m6A methylation and promotes cancer progression via forming a ternary complex with HSPA1A and YBX1 in head and neck squamous cell carcinoma.
Topics: Adenosine; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; HSP70 Heat-Shock Proteins; Humans; Male; Methylation; Methyltransferases; Middle Aged; Models, Biological; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Proteasome Endopeptidase Complex; Proteolysis; RNA Stability; RNA, Long Noncoding; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome; Y-Box-Binding Protein 1 | 2020 |
Analysis of mitochondrial m1A/G RNA modification reveals links to nuclear genetic variants and associated disease processes.
Topics: Adenosine; ATP-Dependent Proteases; Cell Nucleus; Databases, Genetic; Genetic Predisposition to Disease; Genome-Wide Association Study; Guanine; Humans; Methylation; Mitochondria; Mitochondrial Proteins; Mutation, Missense; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Ribonuclease P; RNA Processing, Post-Transcriptional; RNA-Seq; RNA, Mitochondrial; tRNA Methyltransferases | 2020 |
Antiproliferative and Antimigration Activities of Fluoro-Neplanocin A via Inhibition of Histone H3 Methylation in Triple-Negative Breast Cancer.
Topics: Adenosine; Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Halogenation; Histone-Lysine N-Methyltransferase; Histones; Humans; Methylation; Triple Negative Breast Neoplasms | 2020 |
An oncopeptide regulates m
Topics: Adenosine; Animals; Binding Sites; Carcinogenesis; Cell Line, Tumor; Colorectal Neoplasms; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Methylation; Mice; Middle Aged; Prognosis; Proto-Oncogene Proteins c-myc; RNA Processing, Post-Transcriptional; RNA Stability; RNA-Binding Proteins; RNA, Long Noncoding; RNA, Messenger; Survival Analysis; Tissue Array Analysis; Xenograft Model Antitumor Assays | 2020 |
Mechanistic insights into m6A modification of U6 snRNA by human METTL16.
Topics: Adenosine; Amino Acid Sequence; Conserved Sequence; Humans; Methylation; Methyltransferases; Nucleic Acid Conformation; Nucleotidyltransferases; Protein Binding; RNA, Small Nuclear | 2020 |
Deoxyribozyme-based method for absolute quantification of
Topics: Adenosine; DNA, Catalytic; HeLa Cells; Humans; Methylation; RNA | 2020 |
Methyltransferase-like 3-mediated N6-methyladenosine modification of miR-7212-5p drives osteoblast differentiation and fracture healing.
Topics: Adenosine; Animals; Cell Differentiation; Cell Line; Fracture Healing; Gene Expression Regulation; Methylation; Methyltransferases; Mice, Inbred C57BL; MicroRNAs; Osteoblasts; Receptor, Fibroblast Growth Factor, Type 3; RNA-Binding Proteins | 2020 |
m6A RNA methylation regulators correlate with malignant progression and have potential predictive values in clear cell renal cell carcinoma.
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Renal Cell; Cohort Studies; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Male; Methylation; Methyltransferases; Middle Aged; Predictive Value of Tests; Prognosis; RNA Processing, Post-Transcriptional; Survival Analysis; Transcriptome | 2020 |
A metabolic labeling method detects m
Topics: Adenosine; Animals; Cell Line; Gene Expression Profiling; HEK293 Cells; HeLa Cells; Humans; Methylation; Mice; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger; Transcriptome | 2020 |
YTHDF2 promotes the liver cancer stem cell phenotype and cancer metastasis by regulating OCT4 expression via m6A RNA methylation.
Topics: Adenosine; Animals; Carcinoma, Hepatocellular; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Liver; Liver Neoplasms; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Stem Cells; Octamer Transcription Factor-3; Prognosis; RNA-Binding Proteins; RNA, Messenger; Spheroids, Cellular; Transplantation, Heterologous; Tumor Cells, Cultured | 2020 |
RNA m
Topics: Adenosine; Animals; Autophagy; Carcinoma, Hepatocellular; Drug Resistance, Neoplasm; Forkhead Box Protein O3; HEK293 Cells; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Liver Neoplasms; Male; Methylation; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; RNA, Messenger; RNA, Neoplasm; Sorafenib | 2020 |
iMethyl-Deep: N6 Methyladenosine Identification of Yeast Genome with Automatic Feature Extraction Technique by Using Deep Learning Algorithm.
Topics: Adenosine; Algorithms; Benchmarking; Computational Biology; Datasets as Topic; Deep Learning; Genome, Fungal; Methylation; RNA Processing, Post-Transcriptional; RNA, Fungal; ROC Curve; Saccharomyces cerevisiae | 2020 |
Regulation of autophagy in leukocytes through RNA N
Topics: Adenosine; Aged; Autophagy; Female; Humans; Leukocytes; Male; Methylation; Middle Aged; Renal Insufficiency, Chronic; RNA | 2020 |
N
Topics: Adenosine; Cell Line, Tumor; Cytoplasm; Dose-Response Relationship, Drug; Enterovirus A, Human; Humans; Methylation; Methyltransferases; Molecular Structure; RNA, Viral; Structure-Activity Relationship | 2020 |
The protective role of m1A during stress-induced granulation.
Topics: Adenosine; Arsenites; Cytoplasmic Granules; Cytoprotection; Heat-Shock Response; HeLa Cells; Humans; Methylation; Models, Biological; Protein Conformation; RNA-Binding Proteins; RNA, Messenger; Stress, Physiological; tRNA Methyltransferases | 2021 |
A Unified Model for the Function of YTHDF Proteins in Regulating m
Topics: Adenosine; Cell Differentiation; HeLa Cells; Humans; Methylation; Methyltransferases; Protein Biosynthesis; RNA Stability; RNA-Binding Proteins; RNA, Messenger | 2020 |
m
Topics: Adenosine; Animals; Biomarkers; Bone Marrow Failure Disorders; Cell Differentiation; Disease Models, Animal; Epigenesis, Genetic; Gene Expression; Hematopoiesis; Hematopoietic Stem Cells; Immunity, Innate; Immunophenotyping; Methylation; Methyltransferases; Mice; Mice, Knockout; RNA, Double-Stranded | 2020 |
RNA N-6-methyladenosine enzymes and resistance of cancer cells to chemotherapy and radiotherapy.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Cell Cycle Proteins; Drug Resistance, Neoplasm; Humans; Methylation; Methyltransferases; Neoplasms; Radiation Tolerance; RNA; RNA Splicing Factors | 2020 |
M6A-related bioinformatics analysis reveals that HNRNPC facilitates progression of OSCC via EMT.
Topics: Adenosine; Biomarkers, Tumor; Carcinogenesis; Cluster Analysis; Computational Biology; Datasets as Topic; Disease Progression; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Male; Methylation; Middle Aged; Mouth Neoplasms; Principal Component Analysis; Prognosis; Risk Assessment; RNA Processing, Post-Transcriptional; RNA, Messenger; Squamous Cell Carcinoma of Head and Neck | 2020 |
Ling-gui-zhu-gan decoction alleviates hepatic steatosis through SOCS2 modification by N6-methyladenosine.
Topics: Adenosine; Animals; Cholesterol; Diet, High-Fat; DNA Methylation; Fatty Acids, Nonesterified; Fatty Liver; Liver; Male; Methylation; Plant Extracts; Rats; Suppressor of Cytokine Signaling Proteins; Transaminases | 2020 |
Programmable m
Topics: Adenosine; Cell Nucleus; CRISPR-Associated Proteins; Escherichia coli; Gene Editing; Genes, Reporter; Genetic Engineering; HEK293 Cells; Humans; Methylation; Methyltransferases; RNA; RNA, Messenger | 2020 |
FTO-Dependent
Topics: 3' Untranslated Regions; Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Alternative Splicing; Animals; Ascites; Carcinogenesis; Cell Line, Tumor; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 1; Cyclic Nucleotide Phosphodiesterases, Type 4; Down-Regulation; Fallopian Tubes; Female; Gene Knockdown Techniques; Heterografts; Humans; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Ovarian Neoplasms; Ovary; RNA Stability; RNA, Messenger; Second Messenger Systems; Sequence Analysis, RNA; Spheroids, Cellular; Tissue Array Analysis; Transcriptome; Tumor Suppressor Proteins | 2020 |
Control of Early B Cell Development by the RNA N
Topics: Adenosine; Animals; B-Lymphocytes; Base Sequence; Cell Proliferation; Cell Size; Chromatin; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Interleukin-7; Methylation; Methyltransferases; Mice, Knockout; Protein Binding; Protein Biosynthesis; RNA; RNA-Binding Proteins; RNA, Messenger; Transcription Factors; Transcriptional Activation | 2020 |
Recurrent requirement for the m
Topics: Adenosine; Arabidopsis; Arabidopsis Proteins; Binding Sites; Cell Proliferation; Flowers; Gene Expression Regulation, Plant; Intracellular Signaling Peptides and Proteins; Methylation; Methyltransferases; Mutagenesis, Site-Directed; Organogenesis, Plant; Plant Leaves; Plant Roots; Plant Stems; Plants, Genetically Modified; Protein Binding; RNA Interference; RNA-Binding Proteins; RNA, Small Interfering | 2020 |
METTL3 Promotes Tumorigenesis and Metastasis through BMI1 m
Topics: Adenosine; Animals; Binding Sites; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Mice; Mouth Neoplasms; Protein Binding; RNA, Messenger | 2020 |
METTL14 regulates M6A methylation-modified primary miR-19a to promote cardiovascular endothelial cell proliferation and invasion.
Topics: Adenosine; Aged; Atherosclerosis; Cell Movement; Cell Proliferation; Endothelial Cells; Female; Humans; Male; Methylation; Methyltransferases; MicroRNAs; Middle Aged | 2020 |
The m6A methylation regulator-based signature for predicting the prognosis of prostate cancer.
Topics: Adenosine; Cluster Analysis; Computational Biology; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Methylation; Prognosis; Proportional Hazards Models; Prostatic Neoplasms; RNA, Messenger; ROC Curve; Transcriptome | 2020 |
m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation.
Topics: Adenosine; Aged; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Colectomy; Colon; Colonic Neoplasms; Datasets as Topic; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Knockout Techniques; Humans; Male; Methylation; Methyltransferases; Middle Aged; Neoplasm Staging; Receptors, G-Protein-Coupled; RNA Stability; RNA, Messenger; Spheroids, Cellular; Suppressor of Cytokine Signaling Proteins; Tubercidin | 2020 |
Methylation of N6-adenosine (m6A) modification in miRNAs and its implications in immunity.
Topics: Adenosine; Humans; Immune System; Immune System Diseases; Immunity; Methylation; MicroRNAs | 2020 |
Synthesis of Triazole-Linked SAM-Adenosine Conjugates: Functionalization of Adenosine at N-1 or N-6 Position without Protecting Groups.
Topics: Adenosine; Humans; Methylation; Methyltransferases; RNA Processing, Post-Transcriptional; RNA, Messenger; S-Adenosylmethionine; Triazoles | 2020 |
Prognostic Value of an m6A RNA Methylation Regulator-Based Signature in Patients with Hepatocellular Carcinoma.
Topics: Adenosine; Carcinoma, Hepatocellular; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Methylation; Prognosis; Reproducibility of Results; Risk Factors; RNA, Neoplasm | 2020 |
Looping the (R) Loop in DSB Repair via RNA Methylation.
Topics: Adenosine; Ataxia Telangiectasia Mutated Proteins; DNA; DNA Breaks, Double-Stranded; DNA Repair; Methylation; RNA | 2020 |
METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing.
Topics: Adenosine; Catalysis; Exons; Humans; Methylation; Methyltransferases; RNA Precursors; RNA Splice Sites; RNA Splicing; RNA, Messenger; RNA, Small Nuclear; Spliceosomes | 2020 |
mRNA adenosine methylase (MTA) deposits m
Topics: Adenosine; Arabidopsis; Arabidopsis Proteins; Cell Cycle Proteins; Gene Expression Regulation, Plant; Methylation; Methyltransferases; MicroRNAs; RNA-Binding Proteins; RNA, Messenger | 2020 |
β-catenin represses miR455-3p to stimulate m6A modification of HSF1 mRNA and promote its translation in colorectal cancer.
Topics: Adenosine; Animals; Apoptosis; beta Catenin; Cell Line, Tumor; Colorectal Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Heat Shock Transcription Factors; Humans; Methylation; Mice; MicroRNAs; Models, Biological; Protein Biosynthesis; RNA Interference; RNA, Messenger; Xenograft Model Antitumor Assays | 2020 |
N6-methyladenosine regulates PEDV replication and host gene expression.
Topics: Adenosine; Animals; Cell Line; Chlorocebus aethiops; Coronavirus Infections; Gene Expression Regulation; Genome, Viral; Host-Pathogen Interactions; Methylation; Porcine epidemic diarrhea virus; Protein Binding; RNA-Binding Proteins; RNA, Viral; Swine; Swine Diseases; Vero Cells; Virus Replication | 2020 |
m6A RNA methylation impacts fate choices during skin morphogenesis.
Topics: Adenosine; Animals; Computational Biology; Female; Methylation; Methyltransferases; Mice; Organogenesis; RNA, Messenger; Signal Transduction; Skin; Transcriptome | 2020 |
METTL3 regulates m6A in endometrioid epithelial ovarian cancer independently of METTl14 and WTAP.
Topics: Adenosine; Aged; Carcinogenesis; Carcinoma, Endometrioid; Carcinoma, Ovarian Epithelial; Cell Cycle Proteins; Cell Line, Tumor; Cell Transformation, Neoplastic; China; Female; Gene Expression; Gene Expression Profiling; HeLa Cells; Humans; Methylation; Methyltransferases; Middle Aged; RNA Splicing Factors; RNA, Messenger; Transcriptome | 2020 |
RNA m6A methylation promotes the formation of vasculogenic mimicry in hepatocellular carcinoma via Hippo pathway.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Progression; Gene Expression Regulation, Neoplastic; Gene Silencing; Hippo Signaling Pathway; Humans; Liver Neoplasms; Methylation; Methyltransferases; Mice, Inbred BALB C; Mice, Nude; Molecular Mimicry; Prognosis; Protein Biosynthesis; Protein Serine-Threonine Kinases; RNA; RNA, Messenger; Signal Transduction; Transcription Factors; Xenograft Model Antitumor Assays; YAP-Signaling Proteins | 2021 |
Adenylate Kinase 4 Modulates the Resistance of Breast Cancer Cells to Tamoxifen through an m
Topics: Adenosine; Adenylate Kinase; Antineoplastic Agents, Hormonal; Apoptosis; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; MCF-7 Cells; Methylation; Methyltransferases; Reactive Oxygen Species; RNA, Messenger; Signal Transduction; Tamoxifen; Transfection | 2020 |
m6A RNA methylation regulators could contribute to the occurrence of chronic obstructive pulmonary disease.
Topics: Adenosine; Case-Control Studies; Gene Expression Profiling; Gene Expression Regulation; Gene Ontology; Humans; Methylation; Pulmonary Disease, Chronic Obstructive; RNA | 2020 |
Topics: Adenocarcinoma; Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Biomarkers, Tumor; Humans; Immune Checkpoint Proteins; Methylation; Retrospective Studies; RNA; RNA Helicases; Stomach | 2020 |
m
Topics: Adenosine; Animals; Heat-Shock Response; Liver; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger; Sheep | 2021 |
RNA N6-methyladenosine reader IGF2BP3 regulates cell cycle and angiogenesis in colon cancer.
Topics: Adenosine; Animals; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Cyclin D1; DNA Replication; Female; HCT116 Cells; Heterografts; Humans; Male; Methylation; Mice; Neovascularization, Pathologic; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; Vascular Endothelial Growth Factor A | 2020 |
High-resolution structures of the SARS-CoV-2 2'-
Topics: Adenosine; Betacoronavirus; Binding Sites; Catalytic Domain; Coronavirus Infections; COVID-19; Crystallography, X-Ray; Dimerization; Genes, Viral; Humans; Methylation; Methyltransferases; Models, Molecular; Open Reading Frames; Pandemics; Pneumonia, Viral; Protein Binding; Protein Conformation; RNA Cap Analogs; RNA Processing, Post-Transcriptional; RNA, Viral; S-Adenosylhomocysteine; S-Adenosylmethionine; SARS-CoV-2; Structure-Activity Relationship; Viral Nonstructural Proteins | 2020 |
N6-methyladenosine in RNA of atherosclerotic plaques: An epitranscriptomic signature of human carotid atherosclerosis.
Topics: Adenosine; Carotid Artery Diseases; Chromatography, Liquid; Humans; Methylation; Methyltransferases; Oxidoreductases, N-Demethylating; Plaque, Atherosclerotic; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Ribosomal; Tandem Mass Spectrometry | 2020 |
Global profiling of N
Topics: Adenosine; Epigenesis, Genetic; Methylation; RNA, Messenger; Zea mays | 2020 |
The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N
Topics: Adenosine; Animals; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Glycogen Synthase Kinase 3 beta; Heart Ventricles; Hypertrophy, Left Ventricular; Male; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; NFATC Transcription Factors; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; RNA Stability; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Ventricular Function, Left; Ventricular Remodeling | 2020 |
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA.
Topics: Adenosine; Cells, Cultured; Cellular Senescence; Humans; Mesenchymal Stem Cells; Methylation; Methyltransferases; Microtubule-Associated Proteins; Progeria; RNA-Binding Proteins; RNA, Messenger; Werner Syndrome | 2020 |
Fluorescein-based monitoring of RNA N6-methyladenosine at single-nucleotide resolution.
Topics: Adenosine; Animals; Epigenesis, Genetic; Fluorescein; Fluorescent Dyes; Humans; Methylation; Nucleotides | 2021 |
Upregulation of METTL3 expression and m6A RNA methylation in placental trophoblasts in preeclampsia.
Topics: Adenosine; Adult; Case-Control Studies; Female; Gene Expression Regulation, Enzymologic; Humans; Methylation; Methyltransferases; Placenta; Pre-Eclampsia; Pregnancy; RNA Processing, Post-Transcriptional; RNA, Messenger; Trophoblasts; Up-Regulation; Young Adult | 2021 |
Epigenetic modifications of RNA and their implications in antiviral immunity.
Topics: Adenosine; Epigenesis, Genetic; Methylation; Methyltransferases; RNA Folding; RNA Processing, Post-Transcriptional; RNA Splicing; RNA, Viral; SARS-CoV-2 | 2020 |
Site-specific RNA methylation by a methyltransferase ribozyme.
Topics: Adenosine; Base Sequence; Biocatalysis; Guanine; Methylation; Methyltransferases; Plasmids; RNA, Catalytic; RNA, Transfer; S-Adenosylmethionine | 2020 |
Pharmacologic downregulation of protein arginine methyltransferase1 expression by adenosine dialdehyde increases cell senescence in breast cancer.
Topics: Adenosine; Antineoplastic Combined Chemotherapy Protocols; Arginine; Betaine-Homocysteine S-Methyltransferase; Breast Neoplasms; Cell Cycle Checkpoints; Cell Proliferation; Cellular Senescence; Down-Regulation; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Methylation; Molecular Docking Simulation; Oxidative Stress; Phosphatidylethanolamine N-Methyltransferase; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Repressor Proteins; Signal Transduction; Tamoxifen | 2021 |
Analysis of METTL3 and METTL14 in hepatocellular carcinoma.
Topics: Adenosine; Carcinoma, Hepatocellular; Databases, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Liver Neoplasms; Methylation; Methyltransferases; RNA Stability; RNA, Messenger; Signal Transduction; Transcriptome | 2020 |
N6-methyladenosine methyltransferase plays a role in hypoxic preconditioning partially through the interaction with lncRNA H19.
Topics: Adenosine; Animals; Cell Line; Gene Expression Regulation; Hydrogen Peroxide; Ischemic Preconditioning, Myocardial; Male; Methylation; Methyltransferases; Myoblasts, Cardiac; Rats, Sprague-Dawley; RNA; RNA-Binding Proteins; RNA, Long Noncoding | 2020 |
YTHDF1-enhanced iron metabolism depends on TFRC m
Topics: Adenosine; Animals; Antigens, CD; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cohort Studies; Diffusion Magnetic Resonance Imaging; Disease-Free Survival; Gene Expression Regulation, Neoplastic; Humans; Hypopharyngeal Neoplasms; Hypopharynx; Iron; Male; Methylation; Mice; Neoplasm Recurrence, Local; Receptors, Transferrin; RNA-Binding Proteins; RNA, Messenger; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays | 2020 |
m6A methyltransferase Wilms' tumor 1-associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual-specificity phosphatases 6 expression via m6A RNA methylation.
Topics: Adenosine; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; Cell Cycle Proteins; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Dual Specificity Phosphatase 6; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Extranodal NK-T-Cell; Methylation; Nose Neoplasms; RNA Splicing Factors; Tumor Cells, Cultured | 2021 |
Clinicopathological and immunological characterization of RNA m
Topics: Adenosine; Biomarkers, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Methylation; Nerve Tissue Proteins; Nuclear Proteins; Ovarian Neoplasms; RNA Processing, Post-Transcriptional; RNA Splicing Factors; RNA-Binding Proteins | 2021 |
Clinical and prognostic pan-cancer analysis of m6A RNA methylation regulators in four types of endocrine system tumors.
Topics: Adenosine; Biomarkers, Tumor; Cell Cycle Proteins; Databases, Genetic; Endocrine Gland Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Neoplasm Grading; Neoplasm Staging; RNA Splicing Factors; RNA-Binding Proteins; RNA, Neoplasm; Transcriptome | 2020 |
KIAA1429 promotes the progression of lung adenocarcinoma by regulating the m6A level of MUC3A.
Topics: A549 Cells; Adenocarcinoma of Lung; Adenosine; Cell Movement; Cell Proliferation; Databases, Genetic; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Lymphatic Metastasis; Male; Methylation; Middle Aged; Mucin-3; Neoplasm Invasiveness; Neoplasm Staging; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; Signal Transduction; Tumor Burden | 2021 |
Longitudinal epitranscriptome profiling reveals the crucial role of N
Topics: Adenosine; Animals; Cell Differentiation; Embryonic Development; Epigenome; Humans; Methylation; Methyltransferases; Mice; Muscle Development; Muscle, Skeletal; Myoblasts; RNA-Binding Proteins; Swine; Transcriptome | 2020 |
Epitranscriptomic m6A regulation following spinal cord injury.
Topics: Adenosine; Animals; Astrocytes; Epigenesis, Genetic; Gene Expression Profiling; Male; Methylation; Methyltransferases; Mice; Mice, Inbred ICR; Nerve Regeneration; Neural Stem Cells; RNA, Messenger; Spinal Cord Injuries; Zebrafish | 2021 |
Novel Prognostic Implications of Methylated RNA and Demethylases in Resected HCC and Background Liver Tissue.
Topics: Adenosine; Adult; Aged; Aged, 80 and over; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Carcinoma, Hepatocellular; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Liver; Liver Neoplasms; Male; Methylation; Middle Aged; Multivariate Analysis; Prognosis; Proportional Hazards Models; RNA; Survival Analysis | 2020 |
Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis.
Topics: Adenosine; Amines; Catalysis; DNA; Hydrogen; Light; Methylation; Nitrogen; Oxidation-Reduction; Photochemical Processes | 2020 |
TonEBP recognizes R-loops and initiates m6A RNA methylation for R-loop resolution.
Topics: Adenosine; Cell Line, Tumor; Diffusion; DNA; DNA Adducts; DNA Damage; DNA Replication; HEK293 Cells; Humans; Methylation; Methyltransferases; Protein Binding; Protein Interaction Mapping; R-Loop Structures; Ribonuclease H; Transcription Factors; Ultraviolet Rays | 2021 |
Ribosome 18S m
Topics: Adenosine; Animals; Breast Neoplasms; Caenorhabditis elegans; Cell Growth Processes; Cell Line, Tumor; Female; HEK293 Cells; HeLa Cells; Humans; MCF-7 Cells; Methylation; Methyltransferases; RNA, Ribosomal, 18S | 2020 |
Identification of m
Topics: Adenosine; Antibodies; Cell Line, Tumor; Chromatin Immunoprecipitation Sequencing; Gene Library; HEK293 Cells; Humans; MCF-7 Cells; Methylation; Mutation; Nucleotide Motifs; Protein Binding; RNA Processing, Post-Transcriptional; Ultraviolet Rays | 2021 |
Ythdf m
Topics: 3' Untranslated Regions; Adenosine; Animals; Embryo, Nonmammalian; Female; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Methylation; MicroRNAs; Oogenesis; RNA Stability; RNA-Binding Proteins; RNA, Messenger, Stored; Zebrafish; Zebrafish Proteins; Zygote | 2020 |
Detection of locus-specific
Topics: Adenosine; Electrochemical Techniques; Methylation; Silver | 2021 |
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease.
Topics: Adenosine; Aging; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Drosophila; Drosophila Proteins; Humans; Methylation; Methyltransferases; Mice; Neurodegenerative Diseases; RNA Stability | 2021 |
RNA m
Topics: Adenosine; Animals; Bees; Cell Differentiation; Female; Gene Expression Regulation, Developmental; Larva; Methylation; RNA; RNA Processing, Post-Transcriptional; Signal Transduction; Transcriptome; Tubercidin; Vitellogenins | 2021 |
HSM6AP: a high-precision predictor for the Homo
Topics: A549 Cells; Adenosine; Algorithms; Computational Biology; Gene Expression Regulation; HEK293 Cells; HeLa Cells; Humans; Machine Learning; Methylation | 2021 |
Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Carcinogenesis; Carcinoma, Transitional Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; delta-1-Pyrroline-5-Carboxylate Reductase; Disease Progression; Gene Knock-In Techniques; Gene Knockdown Techniques; Humans; Methylation; Mice; Neoplasm Staging; Neoplasm Transplantation; Pyrroline Carboxylate Reductases; RNA Processing, Post-Transcriptional; RNA Stability; RNA, Messenger; Ubiquitin Thiolesterase; Urinary Bladder Neoplasms | 2021 |
Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m
Topics: Adenosine; Calorimetry; Crystallography, X-Ray; Methylation; Molecular Conformation; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Protein Binding; Protein Domains; RNA Splicing Factors; Thermodynamics; Water | 2021 |
Comprehensive analysis of lncRNAs N
Topics: Adenosine; Carcinoma; Case-Control Studies; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Humans; Methylation; RNA, Long Noncoding | 2021 |
Fumonisin B
Topics: Adenosine; Carcinoma, Hepatocellular; Epigenesis, Genetic; Fumonisins; Hep G2 Cells; Humans; Kelch-Like ECH-Associated Protein 1; Liver Neoplasms; Methylation; NF-E2-Related Factor 2; Oxidative Stress; RNA; Signal Transduction | 2021 |
Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific
Topics: Adenosine; Animals; Celiac Disease; Cell Line; Disease Models, Animal; Epithelial Cells; Exportin 1 Protein; HLA-DQ Antigens; Humans; Intestinal Mucosa; Karyopherins; Methylation; Mice, Knockout; NF-kappa B; Polymorphism, Single Nucleotide; Receptors, Cytoplasmic and Nuclear; RNA | 2022 |
Resveratrol Supplementation Attenuates Cognitive and Molecular Alterations under Maternal High-Fat Diet Intake: Epigenetic Inheritance over Generations.
Topics: Adenosine; Animals; Body Weight; Brain; Cognition; Diet, High-Fat; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Inflammation; Leptin; Male; Maternal Exposure; Maze Learning; Methylation; Mice; Neurodegenerative Diseases; Neuronal Plasticity; Obesity; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Resveratrol; Triglycerides | 2021 |
Pan-cancer characterization of expression and clinical relevance of m
Topics: Adenosine; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Methylation; Neoplasm Staging; Neoplasms; Organ Specificity; Prognosis; RNA, Long Noncoding | 2021 |
L1 retrotransposons exploit RNA m
Topics: 5' Untranslated Regions; Adenosine; AlkB Homolog 5, RNA Demethylase; Animals; Evolution, Molecular; HeLa Cells; Humans; Long Interspersed Nucleotide Elements; Methylation; Methyltransferases; Primates; Protein Biosynthesis; Ribonucleoproteins; RNA | 2021 |
Precise identification of an RNA methyltransferase's substrate modification site.
Topics: Adenosine; Base Sequence; Binding Sites; Biosensing Techniques; Humans; Methylation; Methyltransferases; Protein Binding; RNA; RNA Processing, Post-Transcriptional; Single Molecule Imaging | 2021 |
m
Topics: Adenosine; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Calcium; Cell Line, Tumor; Cell Transformation, Neoplastic; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Ion Channels; Melanoma; Methylation; RNA; RNA Interference; Uveal Neoplasms | 2021 |
Emerging Roles of N6-Methyladenosine (m6A) Epitranscriptomics in Toxicology.
Topics: Adenosine; Humans; Methylation; RNA; RNA, Messenger | 2021 |
Identification of a Two-m6A RNA Methylation Regulator Risk Signature as an Independent Prognostic Biomarker in Papillary Renal Cell Carcinoma by Bioinformatic Analysis.
Topics: Adenosine; Biomarkers, Tumor; Carcinoma, Renal Cell; Cluster Analysis; Computational Biology; Female; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Kidney; Kidney Neoplasms; Male; Methylation; Methyltransferases; Prognosis; RNA-Binding Proteins; Transcriptome | 2021 |
Identification of a New Prognostic Risk Signature of Clear Cell Renal Cell Carcinoma Based on N
Topics: Adenosine; Biomarkers, Tumor; Carcinoma, Renal Cell; Computational Biology; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Methylation; Prognosis; Proportional Hazards Models; RNA; Signal Transduction | 2021 |
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.
Topics: Adenosine; Animals; Base Sequence; Cell Line, Tumor; Cell Polarity; Cell Proliferation; Cellular Reprogramming; Cytokines; Gene Deletion; Gene Expression Regulation; Lung Neoplasms; Macrophages; Melanoma, Experimental; Methylation; Methyltransferases; Mice, Knockout; Myeloid Cells; Neoplasm Metastasis; NF-kappa B; Programmed Cell Death 1 Receptor; Repressor Proteins; RNA-Binding Proteins; RNA, Neoplasm; STAT3 Transcription Factor; T-Lymphocytes, Regulatory; Tumor Microenvironment | 2021 |
Expression and Prognostic Characteristics of m6A RNA Methylation Regulators in Colon Cancer.
Topics: Adenosine; Aged; Cell Line, Tumor; Colonic Neoplasms; Female; Gene Expression Regulation, Neoplastic; Genetic Variation; Humans; Male; Methylation; Phenotype; Prognosis; Proportional Hazards Models; Reproducibility of Results; Risk Factors; RNA, Neoplasm | 2021 |
miRNA-mediated loss of m6A increases nascent translation in glioblastoma.
Topics: 3' Untranslated Regions; Adenosine; Base Sequence; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Methylation; MicroRNAs; Microtubule-Associated Proteins; Protein Biosynthesis; RNA Interference; RNA, Messenger; Transcriptome; Tumor Cells, Cultured | 2021 |
Regulation of translation by methylation multiplicity of 18S rRNA.
Topics: Adenosine; Animals; Cell Line; Culture Media; Humans; Methionine; Methylation; Mice; Mutagenesis, Site-Directed; Protein Biosynthesis; Ribosomes; RNA, Ribosomal, 18S; Saccharomyces cerevisiae | 2021 |
RNA modification to the rescue!
Topics: Adenosine; Humans; Methylation; Methyltransferases; RNA, Messenger | 2021 |
RNA N6-methyladenosine: a new player in autophagy-mediated anti-cancer drug resistance.
Topics: Adenosine; Autophagy; Disease Progression; Drug Resistance, Neoplasm; Humans; Methylation; Methyltransferases; Neoplasms; RNA; RNA Processing, Post-Transcriptional | 2021 |
m6A regulator-mediated RNA methylation modification patterns are involved in immune microenvironment regulation of periodontitis.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Cellular Microenvironment; ELAV-Like Protein 1; Epigenesis, Genetic; Fragile X Mental Retardation Protein; Gene Expression Regulation; Humans; Methylation; Neoplasm Proteins; Periodontitis; Protein Interaction Maps; RNA; RNA Processing, Post-Transcriptional; Ubiquitin-Protein Ligases | 2021 |
Expression patterns and prognostic value of m6A RNA methylation regulators in adrenocortical carcinoma.
Topics: Adenosine; Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Biomarkers, Tumor; Datasets as Topic; Down-Regulation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Methylation; Methyltransferases; Middle Aged; Oxidoreductases, N-Demethylating; Prognosis; RNA-Binding Proteins; RNA-Seq; RNA, Messenger; Survival Rate; Up-Regulation | 2021 |
The m
Topics: Adenosine; Animals; Apoptosis; Cell Proliferation; Hypoxia; Male; Methylation; Methyltransferases; Myocytes, Smooth Muscle; PTEN Phosphohydrolase; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA-Binding Proteins; RNA, Messenger; Signal Transduction | 2021 |
mTORC1 stimulates cell growth through SAM synthesis and m
Topics: Adenosine; Animals; Base Sequence; Breast Neoplasms; Cell Cycle Proteins; Cell Proliferation; Female; HEK293 Cells; HeLa Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Methionine Adenosyltransferase; Methylation; Mice, Nude; Protein Biosynthesis; Proto-Oncogene Proteins c-myc; RNA Splicing Factors; RNA, Messenger; S-Adenosylmethionine; Signal Transduction; Transcription, Genetic | 2021 |
Role of epigenetic m
Topics: Adenosine; Animals; Embryo, Nonmammalian; Methylation; Methyltransferases; Neovascularization, Physiologic; Phosphoprotein Phosphatases; Proto-Oncogene Proteins c-akt; TOR Serine-Threonine Kinases; Zebrafish; Zebrafish Proteins | 2021 |
N
Topics: Adenosine; Arabidopsis; Arabidopsis Proteins; Epigenesis, Genetic; Gene Expression Regulation, Plant; Methylation; Reactive Oxygen Species; RNA, Messenger; RNA, Plant; Salt Tolerance; Salts; Transcriptome | 2021 |
Role of Hakai in m
Topics: 5' Untranslated Regions; Adenosine; Alternative Splicing; Animals; Base Sequence; Behavior, Animal; Codon, Initiator; Drosophila melanogaster; Drosophila Proteins; Female; Green Fluorescent Proteins; Male; Methylation; Mutation; Protein Binding; Protein Subunits; RNA, Messenger; Sex Characteristics; Ubiquitin-Protein Ligases; Wings, Animal | 2021 |
Comprehensive analyses of m6A regulators and interactive coding and non-coding RNAs across 32 cancer types.
Topics: Adenosine; Biomarkers, Tumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Methylation; Neoplasms; Organ Specificity; RNA, Messenger; RNA, Untranslated | 2021 |
YTHDF1-regulated expression of TEAD1 contributes to the maintenance of intestinal stem cells.
Topics: Adenosine; Animals; Cell Line; Cell Proliferation; DNA-Binding Proteins; HCT116 Cells; Humans; Intestines; Methylation; Mice; Mice, Knockout; Nuclear Proteins; Organoids; RNA-Binding Proteins; RNA, Messenger; Stem Cells; TEA Domain Transcription Factors; Transcription Factors | 2021 |
[Research update of RNA N
Topics: Adenosine; Cardiovascular Diseases; Humans; Methylation; RNA | 2021 |
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex.
Topics: Adenosine; Cloning, Molecular; COVID-19; Enzyme Assays; Enzyme Inhibitors; Escherichia coli; Gene Expression; Genetic Vectors; High-Throughput Screening Assays; Humans; Kinetics; Methylation; Methyltransferases; Models, Molecular; Recombinant Proteins; RNA Caps; RNA, Viral; SARS-CoV-2; Tritium; Viral Nonstructural Proteins; Viral Regulatory and Accessory Proteins | 2021 |
Transcriptome-wide N6-methyladenosine methylation landscape of coronary artery disease.
Topics: Adenosine; Animals; Computational Biology; Coronary Artery Disease; Humans; Male; Methylation; Rats, Sprague-Dawley; Transcriptome | 2021 |
Methylation of microRNA-338-5p by EED promotes METTL3-mediated translation of oncogene CDCP1 in gastric cancer.
Topics: Adenosine; Aged; Animals; Antigens, Neoplasm; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease-Free Survival; Female; Follow-Up Studies; Gastrectomy; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Methylation; Methyltransferases; Mice; MicroRNAs; Middle Aged; Neoplasm Recurrence, Local; Polycomb Repressive Complex 2; Prognosis; Protein Biosynthesis; Stomach; Stomach Neoplasms; Xenograft Model Antitumor Assays | 2021 |
Functional Characterization of the m
Topics: Adenosine; Erythrocytes; Gene Expression Regulation; Humans; Malaria, Falciparum; Methylation; Plasmodium falciparum; Proteomics; Protozoan Proteins; RNA Processing, Post-Transcriptional; RNA, Messenger | 2021 |
Splice site m
Topics: Adenosine; Amino Acid Sequence; Animals; Base Sequence; Caenorhabditis elegans; Conserved Sequence; Diet; HeLa Cells; Humans; Introns; Methionine Adenosyltransferase; Methylation; Methyltransferases; Mice; Mutation; Nucleic Acid Conformation; Protein Binding; RNA Precursors; RNA Splice Sites; RNA Splicing; RNA, Messenger; RNA, Small Nuclear; S-Adenosylmethionine; Splicing Factor U2AF; Transcriptome | 2021 |
Bioinformatic analyses and experimental validation of the role of m6A RNA methylation regulators in progression and prognosis of adrenocortical carcinoma.
Topics: Adenosine; Adrenal Cortex; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Computational Biology; Datasets as Topic; Disease Progression; Epigenesis, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heterogeneous-Nuclear Ribonucleoprotein Group C; Humans; Immune Checkpoint Inhibitors; Male; Methylation; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Nomograms; RNA; RNA-Binding Proteins; Survival Analysis; Survival Rate; Tumor Microenvironment | 2021 |
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection.
Topics: Adenosine; Cell Line; COVID-19; DEAD Box Protein 58; Humans; Immunity, Innate; Methylation; Methyltransferases; Receptors, Immunologic; RNA, Viral; SARS-CoV-2; Signal Transduction | 2021 |
The m
Topics: Adenosine; Epigenesis, Genetic; Eukaryota; Methylation; Nucleotide Motifs; RNA | 2021 |
Funm6AViewer: a web server and R package for functional analysis of context-specific m6A RNA methylation.
Topics: Adenosine; Animals; Case-Control Studies; Epigenesis, Genetic; Gene Regulatory Networks; Mammals; Methylation; RNA | 2021 |
The cap-specific m6A methyltransferase, PCIF1/CAPAM, is dynamically recruited to the gene promoter in a transcription-dependent manner.
Topics: Adaptor Proteins, Signal Transducing; Adenosine; Chromatin; HeLa Cells; Humans; Methylation; Methyltransferases; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Transport; RNA Polymerase II; RNA, Messenger; Transcription, Genetic | 2021 |
m6A RNA methylation of major satellite repeat transcripts facilitates chromatin association and RNA:DNA hybrid formation in mouse heterochromatin.
Topics: Adenosine; Animals; DNA; Heterochromatin; Methylation; Mice; Mouse Embryonic Stem Cells; RNA; Tandem Repeat Sequences | 2021 |
m6A regulators are associated with osteosarcoma metastasis and have prognostic significance: A study based on public databases.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Biomarkers, Tumor; Datasets as Topic; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Methylation; Methyltransferases; Nerve Tissue Proteins; Osteosarcoma; Prognosis; Proportional Hazards Models; RNA Splicing Factors; RNA-Seq | 2021 |
Mechanisms of anti-vesicular stomatitis virus activity of deazaneplanocin and its 3-brominated analogs.
Topics: Adenosine; Animals; Antiviral Agents; Chlorocebus aethiops; Inhibitory Concentration 50; Methylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Transcription, Genetic; Vero Cells; Vesicular stomatitis Indiana virus; Virus Replication | 2021 |
EDLm
Topics: Adenosine; Animals; Deep Learning; Methylation; Mice; RNA; RNA, Messenger | 2021 |
METTL16 promotes cell proliferation by up-regulating cyclin D1 expression in gastric cancer.
Topics: Adenosine; Adult; Aged; Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Female; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Male; Methylation; Methyltransferases; Mice; Middle Aged; Prognosis; RNA Stability; Stomach Neoplasms | 2021 |
Targeted RNA m
Topics: Adenosine; Base Sequence; Cell Line, Tumor; Clustered Regularly Interspaced Short Palindromic Repeats; CRISPR-Cas Systems; Gene Editing; HeLa Cells; Humans; Methylation; RNA; RNA, Messenger | 2021 |
Targeted RNA N
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Caspases; Catalytic Domain; Cell Differentiation; Cell Lineage; Cell Proliferation; Demethylation; Embryonic Stem Cells; Humans; Methylation; Methyltransferases; Pluripotent Stem Cells; RNA Stability; RNA, Messenger; SOXB1 Transcription Factors | 2021 |
The pan-cancer analysis of the two types of uterine cancer uncovered clinical and prognostic associations with m6A RNA methylation regulators.
Topics: Adenosine; Age Factors; Biomarkers, Tumor; Carcinosarcoma; Case-Control Studies; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Methylation; Methyltransferases; Neoplasm Grading; Prognosis; RNA-Binding Proteins; Sequence Analysis, RNA; Survival Rate; Uterine Neoplasms | 2021 |
Exploration of the potential roles of m6A regulators in the uterus in pregnancy and infertility.
Topics: Abortion, Habitual; Adenosine; AlkB Homolog 5, RNA Demethylase; Animals; Biopsy; Cell Cycle Proteins; Datasets as Topic; Embryo Implantation; Endometrium; Epigenesis, Genetic; Female; Humans; Infertility, Female; Male; Methylation; Methyltransferases; Mice; Models, Animal; Pregnancy; Protein Interaction Mapping; Protein Interaction Maps; RNA Splicing Factors; RNA-Binding Proteins; RNA, Messenger | 2021 |
Hakai is required for stabilization of core components of the m
Topics: Adenosine; Animals; Cell Line; Drosophila melanogaster; Drosophila Proteins; HeLa Cells; Humans; Methylation; Methyltransferases; RNA Processing, Post-Transcriptional; RNA Splicing; RNA, Messenger; Ubiquitin-Protein Ligases | 2021 |
RNA methylation and neurovascular unit remodeling.
Topics: 5-Methylcytosine; Adenosine; Methylation; Methyltransferases; RNA | 2021 |
m6A RNA methylation regulators were associated with the malignancy and prognosis of ovarian cancer.
Topics: Adenosine; Databases, Genetic; Female; Gene Regulatory Networks; Humans; Methylation; Neoplasm Invasiveness; Ovarian Neoplasms; Prognosis; RNA; Transcriptome | 2021 |
The m
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Base Pairing; Base Sequence; Cell Line, Tumor; Endonucleases; Epigenesis, Genetic; Herpesvirus 8, Human; Heterogeneous-Nuclear Ribonucleoprotein Group C; Host-Pathogen Interactions; Humans; Lymphocytes; Methylation; Methyltransferases; Nucleic Acid Conformation; Reverse Transcription; RNA-Binding Proteins; RNA, Long Noncoding; RNA, Messenger; RNA, Nuclear; Sequence Analysis, RNA; Transcriptome | 2021 |
The m
Topics: Adenosine; Adult; Aged; Aged, 80 and over; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Carcinogenesis; Female; Gene Expression; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Male; Mass Spectrometry; Methylation; Methyltransferases; Middle Aged; Poland; RNA; RNA Helicases; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; Squamous Cell Carcinoma of Head and Neck; tRNA Methyltransferases | 2021 |
Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; COVID-19; Gene Expression Regulation; Humans; Methylation; Methyltransferases; Protein Processing, Post-Translational; RNA-Dependent RNA Polymerase; RNA, Viral; SARS-CoV-2; Virus Replication | 2021 |
Immune infiltration-related N6-methyladenosine RNA methylation regulators influence the malignancy and prognosis of endometrial cancer.
Topics: Adenosine; Cell Line, Tumor; Cell Proliferation; Disease-Free Survival; DNA Copy Number Variations; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Ligands; Lymphocytes, Tumor-Infiltrating; Methylation; Middle Aged; Molecular Docking Simulation; Mutation; Neoplasm Invasiveness; Neoplasm Proteins; Prognosis; Proportional Hazards Models; RNA, Messenger; Small Molecule Libraries; Tumor Microenvironment | 2021 |
m6A RNA methylation in heart development, regeneration and disease.
Topics: Adenosine; Methylation; Regeneration; RNA | 2021 |
End-labeling-based electrochemical strategy for detection of adenine methylation in nucleic acid by differential pulse voltammetry.
Topics: Adenine; Adenosine; Antibodies, Monoclonal; Armoracia; DNA; Electrochemical Techniques; Escherichia coli; Gold; HeLa Cells; Horseradish Peroxidase; Humans; Immobilized Nucleic Acids; Immunoglobulin G; Limit of Detection; Metal Nanoparticles; Methylation; Reproducibility of Results; RNA | 2021 |
Transcriptional regulation of N
Topics: Adenosine; Animals; Energy Metabolism; Female; Gene Expression Regulation; Lipid Metabolism; Male; Methylation; Mice; Proto-Oncogene Proteins c-bcl-6; Quantitative Trait, Heritable; Sex Factors; Signal Transduction; STAT5 Transcription Factor; Transcription, Genetic | 2021 |
Vitamin B
Topics: Adenosine; Animals; Fibroblasts; Gene Expression Regulation; Methylation; Mice, Knockout; Protein Kinase C-alpha; Receptors, Cell Surface; Recombinant Fusion Proteins; RNA, Messenger; S-Adenosylmethionine; Transcobalamins; Vitamin B 12 Deficiency | 2021 |
m
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; CRISPR-Cas Systems; Cryptosporidiosis; Cryptosporidium parvum; Epithelium; Gene Expression Regulation; GTP Phosphohydrolases; GTP-Binding Proteins; Humans; Immunity, Innate; Intestinal Mucosa; Methylation; Mice; Mice, Inbred C57BL; NF-kappa B; RNA Interference; RNA Processing, Post-Transcriptional; RNA, Messenger; RNA, Small Interfering | 2021 |
Multi-omic analysis of altered transcriptome and epigenetic signatures in the UV-induced DNA damage response.
Topics: Adenosine; Cell Line; DNA; DNA Damage; DNA Methylation; DNA Repair; Epigenesis, Genetic; Epigenomics; Fibroblasts; Gene Expression Profiling; Humans; Methylation; RNA; RNA Processing, Post-Transcriptional; Transcription, Genetic; Transcriptome; Ultraviolet Rays | 2021 |
C5aR1-positive neutrophils promote breast cancer glycolysis through WTAP-dependent m6A methylation of ENO1.
Topics: Adenosine; Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Disease Progression; DNA-Binding Proteins; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Male; Metabolome; Methylation; Mice, Inbred BALB C; Mice, Nude; Models, Biological; Neutrophils; Phosphopyruvate Hydratase; Phosphorylation; Principal Component Analysis; Promoter Regions, Genetic; Protein Stability; Receptor, Anaphylatoxin C5a; RNA Splicing Factors; Signal Transduction; Stochastic Processes; Survival Analysis; Tumor Suppressor Proteins; Up-Regulation | 2021 |
N1-methyladenosine profiling of long non-coding RNA in colorectal cancer.
Topics: Adenosine; Chromosome Mapping; Cluster Analysis; Colorectal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Ontology; Humans; Immunoprecipitation; Methylation; RNA, Long Noncoding; Sequence Analysis, RNA | 2021 |
The m6A mRNA demethylase FTO in granulosa cells retards FOS-dependent ovarian aging.
Topics: 3' Untranslated Regions; Adenosine; Aging; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Case-Control Studies; Cell Line; Down-Regulation; Female; Gene Silencing; Granulosa Cells; Humans; Methylation; Models, Biological; Ovary; Proto-Oncogene Proteins c-fos; Reactive Oxygen Species; RNA Stability; RNA, Messenger; Up-Regulation | 2021 |
m
Topics: 5' Untranslated Regions; Activating Transcription Factors; Adenosine; Base Sequence; HEK293 Cells; Humans; Immunoprecipitation; Methylation; RNA, Messenger; Transcriptome | 2021 |
Identification of m6A-Related Biomarkers Associated with Prognosis of Colorectal Cancer.
Topics: Adenocarcinoma; Adenosine; Biomarkers, Tumor; Colonic Neoplasms; Datasets as Topic; Epigenesis, Genetic; Esophageal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Methylation; Prognosis; Protein Interaction Maps; Rectal Neoplasms; Survival Analysis | 2021 |
Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation.
Topics: Adenosine; Cell Cycle Proteins; Enhancer Elements, Genetic; Gene Expression Regulation; Humans; Methylation; Nerve Tissue Proteins; Regulatory Elements, Transcriptional; RNA; RNA Splicing Factors; Transcription Factors; Transcriptional Activation | 2021 |
N6-methyladenosine (m6A) RNA methylation regulator SNRPC is a prognostic biomarker and is correlated with immunotherapy in hepatocellular carcinoma.
Topics: Adenosine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Endothelial Cells; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy; Liver Neoplasms; Methylation; Prognosis; RNA; Tumor Microenvironment | 2021 |
A seven-m6A regulator-related CpG site-based prognostic signature for endometrial carcinoma.
Topics: Adenosine; Biomarkers, Tumor; China; Endometrial Neoplasms; Female; Gene Expression Regulation, Neoplastic; Humans; Methylation; Middle Aged; Nomograms; Predictive Value of Tests; Prognosis; Proportional Hazards Models; RNA; Survival Analysis | 2021 |
Quantitative analysis of m
Topics: Adenine; Adenosine; Biochemical Phenomena; Chromatography, Liquid; Methylation; Nucleosides; RNA; RNA, Messenger; Tandem Mass Spectrometry | 2021 |
The germinal center reaction depends on RNA methylation and divergent functions of specific methyl readers.
Topics: Adenosine; Animals; B-Lymphocytes; Cell Cycle; Gene Expression Regulation; Genes, myc; Germinal Center; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Phosphorylation; RNA; RNA-Binding Proteins; Smegmamorpha; Spleen | 2021 |
Characteristic of molecular subtypes in lung adenocarcinoma based on m6A RNA methylation modification and immune microenvironment.
Topics: Adenocarcinoma of Lung; Adenosine; Biomarkers, Tumor; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Prognosis; RNA Processing, Post-Transcriptional; Survival Rate; Transcriptome; Tumor Microenvironment | 2021 |
Caspases Switch off the m
Topics: Adenosine; Caspases; Cell Line; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Methylation; Oncogenic Viruses; RNA Processing, Post-Transcriptional; RNA, Messenger; Virus Replication | 2021 |
Loss of m
Topics: Adenosine; Adenoviridae; Animals; Cell Cycle; Heart; Humans; Male; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Myocardial Infarction; Regeneration; RNA, Messenger; Signal Transduction; Transfection; Up-Regulation | 2021 |
A Risk Signature Consisting of Eight m
Topics: Adenosine; Gene Expression Regulation, Neoplastic; Glioma; Humans; Methylation; Protein Processing, Post-Translational; RNA-Binding Proteins | 2022 |
Mechanism of noncoding RNA-associated N
Topics: Adenosine; Animals; B-Lymphocytes; Cytidine Deaminase; Exosome Multienzyme Ribonuclease Complex; Female; Genomic Instability; HEK293 Cells; Humans; Immunoglobulin Class Switching; Immunoglobulin Heavy Chains; Male; Membrane Proteins; Methylation; Methyltransferases; Mice, Knockout; Recombination, Genetic; RNA 3' End Processing; RNA, Long Noncoding; RNA, Untranslated | 2021 |
Interaction of tau with HNRNPA2B1 and N
Topics: Adenosine; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Case-Control Studies; Cerebral Cortex; Disease Models, Animal; Disease Progression; Female; HEK293 Cells; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Male; Methylation; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Protein Aggregates; Protein Aggregation, Pathological; RNA; RNA Processing, Post-Transcriptional; Severity of Illness Index; tau Proteins | 2021 |
M6A-GSMS: Computational identification of N
Topics: Adenosine; Arabidopsis; Humans; Methylation; RNA | 2022 |
N6-methyladenosine (m6A) modification and its clinical relevance in cognitive dysfunctions.
Topics: Adenosine; Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Brain; Cognition; Cognitive Dysfunction; Datasets as Topic; Dementia, Vascular; Female; Humans; Male; Methylation; Methyltransferases; RNA Processing, Post-Transcriptional; RNA, Messenger; snRNP Core Proteins | 2021 |
Expression pattern and prognostic value of N6-methyladenosine RNA methylation key regulators in hepatocellular carcinoma.
Topics: Adenosine; Biomarkers, Tumor; Carcinoma, Hepatocellular; Cluster Analysis; Computational Biology; Databases, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Methylation; Prognosis; Protein Interaction Mapping; Protein Interaction Maps; RNA; ROC Curve; Transcriptome | 2021 |
Establishment of transposase-assisted low-input m
Topics: Adenosine; Gene Library; Humans; Methylation; Sequence Analysis, RNA; Transposases; Workflow | 2021 |
METTL3 Intensifies the Progress of Oral Squamous Cell Carcinoma via Modulating the m6A Amount of PRMT5 and PD-L1.
Topics: Adenosine; Animals; B7-H1 Antigen; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Methylation; Methyltransferases; Mice; Mouth Neoplasms; Protein-Arginine N-Methyltransferases; RNA, Messenger; Squamous Cell Carcinoma of Head and Neck; Xenograft Model Antitumor Assays | 2021 |
m
Topics: A549 Cells; Adenosine; AlkB Homolog 5, RNA Demethylase; Gene Expression Profiling; Gene Knockdown Techniques; HEK293 Cells; Humans; Methylation; MicroRNAs; Sequence Analysis, RNA | 2021 |
METTL3-mediated RNA m6A Hypermethylation Promotes Tumorigenesis and GH Secretion of Pituitary Somatotroph Adenomas.
Topics: Adenoma; Adenosine; Adult; Aged; Aged, 80 and over; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Chromogranins; Epigenesis, Genetic; Female; GADD45 Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Growth Hormone-Secreting Pituitary Adenoma; GTP-Binding Protein alpha Subunits, Gs; Human Growth Hormone; Humans; Intracellular Signaling Peptides and Proteins; Male; Methylation; Methyltransferases; Middle Aged; Pituitary Gland; Pituitary Neoplasms; RNA; Young Adult | 2022 |
The tumor-suppressive effects of alpha-ketoglutarate-dependent dioxygenase FTO via N6-methyladenosine RNA methylation on bladder cancer patients.
Topics: Adenosine; Aged; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Cell Line, Tumor; Female; Humans; Male; Methylation; Middle Aged; PTB-Associated Splicing Factor; RNA, Messenger; Urinary Bladder Neoplasms | 2021 |
DNAzyme based three-way junction assay for antibody-free detection of locus-specific N
Topics: Adenosine; Biosensing Techniques; DNA, Catalytic; Methylation; RNA | 2021 |
METTL3-mediated m
Topics: Adenosine; Animals; Carcinogenesis; Cell Line, Tumor; Gene Deletion; Homeostasis; Interleukin-15; Killer Cells, Natural; Lymphocytes, Tumor-Infiltrating; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Neoplasms; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proto-Oncogene Proteins c-akt; RNA; Signal Transduction; Tumor Microenvironment | 2021 |
HIV reprograms host m
Topics: 5' Untranslated Regions; Adaptor Proteins, Signal Transducing; Adenosine; Genome, Viral; HIV Infections; HIV-1; Humans; Methylation; Nuclear Proteins; Protein Stability; Proteolysis; Proto-Oncogene Mas; Proto-Oncogene Protein c-ets-1; RNA; RNA Stability; RNA, Messenger; RNA, Viral; Transcription, Genetic; Virus Replication; vpr Gene Products, Human Immunodeficiency Virus | 2021 |
METTL3-m
Topics: Adenosine; Animals; Autophagy; Intracellular Signaling Peptides and Proteins; Methylation; Methyltransferases; Mice; Non-alcoholic Fatty Liver Disease; RNA-Binding Proteins | 2022 |
Xeno nucleic acid probes mediated methylation-specific PCR for single-base resolution analysis of N
Topics: Adenosine; Methylation; Real-Time Polymerase Chain Reaction; RNA, Long Noncoding; RNA, Messenger | 2021 |
METTL3-mediated M6A methylation modification is involved in colistin-induced nephrotoxicity through apoptosis mediated by Keap1/Nrf2 signaling pathway.
Topics: Adenosine; Animals; Animals, Outbred Strains; Anti-Bacterial Agents; Apoptosis; Colistin; Down-Regulation; Female; Kelch-Like ECH-Associated Protein 1; Kidney; Methylation; Methyltransferases; Mice; NF-E2-Related Factor 2; Oxidative Stress; RNA, Messenger; Signal Transduction | 2021 |
m6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation.
Topics: Adenosine; Adipose Tissue, Beige; Adipose Tissue, White; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Diet, High-Fat; Energy Metabolism; Hypoxia-Inducible Factor 1, alpha Subunit; Methylation; Mice; Mice, Inbred C57BL; Thermogenesis | 2021 |
N6-Methyladenosine-Related lncRNA Signature Predicts the Overall Survival of Colorectal Cancer Patients.
Topics: Adenosine; Biomarkers, Tumor; Colorectal Neoplasms; Datasets as Topic; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; Methylation; Middle Aged; Nomograms; Risk Assessment; RNA, Long Noncoding | 2021 |
The landscape of m
Topics: Adenosine; Biomarkers, Tumor; Computational Biology; Disease Susceptibility; Gene Expression Regulation, Neoplastic; Genetic Variation; Humans; Lung Neoplasms; Methylation; Prognosis; RNA; Signal Transduction; Small Cell Lung Carcinoma | 2021 |
Single-molecule RNA sequencing for simultaneous detection of m6A and 5mC.
Topics: Adenosine; Cell Line, Tumor; Colorectal Neoplasms; Cytidine; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Methylation; MicroRNAs; Sequence Analysis, RNA; Single Molecule Imaging | 2021 |
Multiplexed magnetic beads-assisted amperometric bioplatforms for global detection of methylations in nucleic acids.
Topics: Adenosine; Humans; Magnetic Phenomena; Methylation; Nucleic Acids; RNA | 2021 |
m
Topics: Adenosine; Immunoprecipitation; Methylation; RNA; RNA, Messenger | 2022 |
m6A regulator-mediated RNA methylation modification patterns and immune microenvironment infiltration characterization in severe asthma.
Topics: Adenosine; Animals; Asthma; Biomarkers; Cellular Microenvironment; Computational Biology; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Methylation; Mice; Models, Biological; RNA, Messenger; ROC Curve; Severity of Illness Index; Transcriptome | 2021 |
Mycotoxins exacerbate HIV infection: the potential of N
Topics: Adenosine; HIV Infections; Humans; Methylation; Mycotoxins; RNA | 2021 |
METTL3-mediated m
Topics: Adenosine; Animals; Autophagy; Autophagy-Related Protein 7; Cartilage, Articular; Cell Line; Cellular Senescence; Chondrocytes; Coculture Techniques; Disease Models, Animal; Disease Progression; Female; GATA4 Transcription Factor; Gene Expression; Humans; Immunoprecipitation; Male; Methylation; Methyltransferases; Mice; Middle Aged; Osteoarthritis; RNA Processing, Post-Transcriptional; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Synoviocytes; Up-Regulation | 2022 |
Radiogenomics Map Reveals the Landscape of m6A Methylation Modification Pattern in Bladder Cancer.
Topics: Adenosine; Biomarkers, Tumor; Computational Biology; Databases, Genetic; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; Methylation; Mutation; Prognosis; RNA, Messenger; ROC Curve; Tomography, X-Ray Computed; Urinary Bladder Neoplasms | 2021 |
m
Topics: 3' Untranslated Regions; Adenosine; Aged; Aged, 80 and over; Apoptosis; Aquaporin 1; Cartilage, Articular; Cells, Cultured; Chondrocytes; Disease Progression; Extracellular Matrix; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Methylation; MicroRNAs; Middle Aged; Models, Biological; Osteoarthritis; Phosphate Transport Proteins; RNA Interference; RNA, Long Noncoding | 2021 |
Comprehensive of N1-Methyladenosine Modifications Patterns and Immunological Characteristics in Ovarian Cancer.
Topics: Adenosine; Carcinoma, Ovarian Epithelial; Female; Humans; Methylation; Ovarian Neoplasms; RNA Processing, Post-Transcriptional; Tumor Microenvironment | 2021 |
Alteration of the m
Topics: Adenosine; Animals; Autoimmune Diseases; Bleomycin; Connective Tissue Diseases; Disease Models, Animal; Female; Fibrosis; Gene Expression; Methylation; Mice, Inbred BALB C; RNA, Messenger; Skin | 2021 |
Comprehensive Analysis of m6A RNA Methylation Regulators and the Immune Microenvironment to Aid Immunotherapy in Pancreatic Cancer.
Topics: Adenocarcinoma; Adenosine; Biomarkers, Tumor; Cohort Studies; Databases, Genetic; Gene Expression Regulation, Neoplastic; Humans; Immunotherapy; Kaplan-Meier Estimate; Methylation; Pancreatic Neoplasms; Prognosis; RNA; Transcriptome; Tumor Microenvironment | 2021 |
Unique features of the m
Topics: Adenosine; Droughts; Gene Expression Profiling; Gene Expression Regulation, Plant; Hippophae; Methylation; Phylogeny; Plant Proteins; RNA, Messenger; Signal Transduction; Stress, Physiological; Transcriptome | 2021 |
Survival-associated N
Topics: Adenine; Adenosine; Aged; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Databases, Genetic; Female; Gene Expression; Humans; Immunohistochemistry; Lung Neoplasms; Male; Methylation; Methyltransferases; Middle Aged; Principal Component Analysis; Prognosis; RNA, Messenger; ROC Curve; Survival Rate; Time Factors | 2021 |
Direct RNA Sequencing Reveals SARS-CoV-2 m6A Sites and Possible Differential DRACH Motif Methylation among Variants.
Topics: 3' Untranslated Regions; Adenosine; Animals; Chlorocebus aethiops; COVID-19; Genome, Viral; Humans; Immune Evasion; Methylation; Nanopore Sequencing; Open Reading Frames; RNA, Viral; SARS-CoV-2; Sequence Analysis, RNA; Vero Cells | 2021 |
Fat mass and obesity-associated protein regulates RNA methylation associated with depression-like behavior in mice.
Topics: Adenosine; Adult; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Case-Control Studies; Depressive Disorder, Major; Disease Models, Animal; Down-Regulation; Female; Gene Knockdown Techniques; Healthy Volunteers; Hippocampus; Humans; Male; Methylation; Mice; Mice, Knockout; Middle Aged; Receptors, Adrenergic, beta-2; Young Adult | 2021 |
The N6-Methyladenosine- (m6A-) Associated Genes Act as Strong Key Biomarkers for the Prognosis of Pancreatic Adenocarcinoma.
Topics: Adenocarcinoma; Adenosine; Biomarkers, Tumor; Computational Biology; Databases, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Humans; Male; Methylation; Pancreatic Neoplasms; Prognosis; Proportional Hazards Models; Protein Interaction Maps; RNA-Binding Proteins | 2021 |
Up-to-date on the evidence linking miRNA-related epitranscriptomic modifications and disease settings. Can these modifications affect cross-kingdom regulation?
Topics: 3' Untranslated Regions; Adenosine; Animals; Base Pairing; Binding Sites; Disease Susceptibility; Epigenesis, Genetic; Gene Expression Regulation, Plant; Humans; Methylation; MicroRNAs; RNA Interference; RNA Processing, Post-Transcriptional; Transcriptome | 2021 |
m6A-Maize: Weakly supervised prediction of m
Topics: Adenosine; High-Throughput Nucleotide Sequencing; Methylation; Mutation; Zea mays | 2022 |
N6-Methyladenosine Methylation Analysis of Long Noncoding RNAs and mRNAs in IPEC-J2 Cells Treated With
Topics: Adenosine; Animals; Bacterial Toxins; Cell Line; Clostridium Infections; Clostridium perfringens; Epithelial Cells; Gene Expression Regulation; Gene Ontology; Intestinal Mucosa; Methylation; Reverse Transcriptase Polymerase Chain Reaction; RNA-Seq; RNA, Long Noncoding; RNA, Messenger; Signal Transduction; Swine; Transcriptome | 2021 |
m6A Regulator-Mediated Methylation Modification Patterns and Tumor Microenvironment Infiltration Characterization in Acute Myeloid Leukemia.
Topics: Adenosine; B7-H1 Antigen; Biomarkers, Tumor; Case-Control Studies; Databases, Genetic; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Methylation; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Mutation; Programmed Cell Death 1 Ligand 2 Protein; RNA Processing, Post-Transcriptional; RNA, Neoplasm; Signal Transduction; Tumor Microenvironment | 2021 |
Detection of N6-methyladenosine in SARS-CoV-2 RNA by methylated RNA immunoprecipitation sequencing.
Topics: Adenosine; Animals; Caco-2 Cells; Chlorocebus aethiops; COVID-19; Gene Expression; Gene Expression Regulation; Genetic Techniques; HEK293 Cells; Humans; Immunoprecipitation; Methylation; RNA; RNA Processing, Post-Transcriptional; RNA, Viral; SARS-CoV-2; Sequence Analysis, RNA; Vero Cells | 2022 |
Sperm DNA 5-methyl cytosine and RNA N6-methyladenosine methylation are differently affected during periods of body weight losses and body weight gain of young and mature breeding bulls.
Topics: Adenosine; Animals; Body Weight; Breeding; Cattle; Cytosine; DNA; Male; Methylation; RNA; Semen; Sperm Motility; Spermatozoa; Weight Loss | 2022 |
Activation of YAP1 by N6-Methyladenosine-Modified circCPSF6 Drives Malignancy in Hepatocellular Carcinoma.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Male; Methylation; Middle Aged; Prognosis; RNA-Binding Proteins; RNA, Circular; YAP-Signaling Proteins | 2022 |
Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus.
Topics: Adaptive Immunity; Adenosine; Animals; Immunity, Innate; Methylation; Mice; Rats; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; RNA, Viral | 2021 |
m
Topics: Adenosine; Biomarkers, Tumor; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genomics; Humans; Methylation; Neoplasm Proteins; Sarcoma; Transcriptome; Tumor Microenvironment | 2022 |
METTL14 suppresses pyroptosis and diabetic cardiomyopathy by downregulating TINCR lncRNA.
Topics: Adenosine; Animals; Diabetic Cardiomyopathies; Down-Regulation; Epigenesis, Genetic; Methylation; Methyltransferases; Myocytes, Cardiac; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Rats; RNA Stability; RNA-Binding Proteins; RNA, Long Noncoding | 2022 |
Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance.
Topics: Adenosine; Anti-Bacterial Agents; Binding Sites; Directed Molecular Evolution; Drug Resistance, Microbial; Escherichia coli; Escherichia coli Proteins; Methylation; Methyltransferases; RNA, Ribosomal | 2022 |
The METTL5-TRMT112 N
Topics: Adenosine; Animals; Methylation; Methyltransferases; Mice; Protein Biosynthesis; RNA, Messenger; RNA, Ribosomal, 18S; RNA, Ribosomal, 28S | 2022 |
Identification of an m6A RNA Methylation Regulator Risk Score Model for Prediction of Clinical Prognosis in Astrocytoma.
Topics: Adenosine; Astrocytoma; Central Nervous System Neoplasms; Computational Biology; Databases, Genetic; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Methylation; Methyltransferases; Models, Genetic; Prognosis; Proportional Hazards Models; Risk Factors; RNA Processing, Post-Transcriptional; RNA, Messenger | 2022 |
Involvement of N6-methyladenosine modifications of long noncoding RNAs in systemic lupus erythematosus.
Topics: Adenosine; Adult; Base Sequence; Case-Control Studies; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Leukocytes, Mononuclear; Lupus Erythematosus, Systemic; Male; Methylation; Middle Aged; Reproducibility of Results; RNA, Long Noncoding; RNA, Messenger; T-Lymphocytes | 2022 |
Glucocorticoid Regulates the Synthesis of Porcine Muscle Protein through m
Topics: Adenosine; Amino Acid Transport System y+L; Animals; Gene Expression Regulation; Glucocorticoids; Methylation; Mifepristone; Muscle Fibers, Skeletal; Muscle Proteins; Protein Biosynthesis; Receptors, Glucocorticoid; Swine | 2022 |
Intermittent Fasting Improves High-Fat Diet-Induced Obesity Cardiomyopathy via Alleviating Lipid Deposition and Apoptosis and Decreasing m6A Methylation in the Heart.
Topics: Adenosine; Animals; Apoptosis; Cardiomyopathies; Diet, High-Fat; Echocardiography; Fasting; Lipid Metabolism; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Obese; Myocardium; Obesity; Random Allocation; RNA, Messenger | 2022 |
m
Topics: Adenosine; Methylation; RNA; RNA, Messenger; Transcriptome | 2022 |
scDART-seq reveals distinct m
Topics: Adenosine; Gene Expression Profiling; HEK293 Cells; Humans; Methylation; RNA Processing, Post-Transcriptional; RNA, Messenger; Sequence Analysis, RNA; Single-Cell Analysis; Transcriptome | 2022 |
N6-Methyladenosine-Related LncRNAs Are Potential Remodeling Indicators in the Tumor Microenvironment and Prognostic Markers in Osteosarcoma.
Topics: Adenosine; Biomarkers, Tumor; Computational Biology; Databases, Genetic; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lymphocytes, Tumor-Infiltrating; Methylation; Osteosarcoma; Prognosis; RNA, Long Noncoding; ROC Curve; Transcriptome; Tumor Microenvironment | 2021 |
Differential release of extracellular vesicle tRNA from oxidative stressed renal cells and ischemic kidneys.
Topics: Acute Kidney Injury; Adenosine; Animals; Cell Line; Disease Models, Animal; Extracellular Vesicles; Ischemia; Kidney; Methylation; Mice; Oxidative Stress; Rats, Sprague-Dawley; Repressor Proteins; RNA, Transfer; Transcription, Genetic | 2022 |
Epitranscriptomic regulation of HIV-1 full-length RNA packaging.
Topics: 5' Untranslated Regions; Adenosine; Gene Products, gag; HIV-1; Methylation; RNA, Viral; Virion | 2022 |
Methyltransferase-like (METTL)14-mediated N6-methyladenosine modification modulates retinal pigment epithelial (RPE) activity by regulating the methylation of microtubule-associated protein (MAP)2.
Topics: Adenosine; Humans; Methylation; Methyltransferases; Microtubule-Associated Proteins; Retinal Pigment Epithelium; RNA | 2022 |
Comprehensive analysis of differences in N6-methyladenosine RNA methylomes in the rat adenohypophysis after GnRH treatment.
Topics: Adenosine; Animals; Gonadotropin-Releasing Hormone; Male; Methylation; Pituitary Gland, Anterior; Rats; Rats, Sprague-Dawley; RNA Processing, Post-Transcriptional | 2022 |
Methylation recognition protein YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) regulates the proliferation, migration and invasion of osteosarcoma by regulating m6A level of CCR4-NOT transcription complex subunit 7 (CNOT7).
Topics: Adenosine; Bone Neoplasms; Cell Proliferation; Exoribonucleases; Humans; Methylation; Methyltransferases; Osteosarcoma; Receptors, CCR4; Repressor Proteins; RNA-Binding Proteins; RNA, Messenger | 2022 |
m6A-Finder: Detecting m6A methylation sites from RNA transcriptomes using physical and statistical properties based features.
Topics: Adenosine; Methylation; RNA; Sequence Analysis, RNA; Transcriptome | 2022 |
The m6A(m)-independent role of FTO in regulating WNT signaling pathways.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; beta Catenin; Cell Movement; Cell Proliferation; Gene Expression; Gene Expression Regulation; Humans; Intercellular Signaling Peptides and Proteins; Methylation; RNA, Messenger; Wnt Signaling Pathway | 2022 |
The m
Topics: Adenosine; Cell Line, Tumor; Endoribonucleases; Gene Expression; Gene Expression Regulation, Viral; HEK293 Cells; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Interleukin-6; Methylation; RNA Helicases; RNA Stability; RNA, Messenger; RNA, Viral; Viral Proteins; Virus Replication | 2022 |
Correlation analysis of m6A-modified regulators with immune microenvironment infiltrating cells in lung adenocarcinoma.
Topics: Adenocarcinoma of Lung; Adenosine; Humans; Lung Neoplasms; Lymphocytes, Tumor-Infiltrating; Methylation; RNA; RNA Processing, Post-Transcriptional; Tumor Microenvironment | 2022 |
The Combined Effects of Circular RNA Methylation Promote Pulmonary Fibrosis.
Topics: Adenosine; Humans; Methylation; Methyltransferases; Pulmonary Fibrosis; RNA, Circular; Silicon Dioxide | 2022 |
Global N
Topics: Adenosine; Gene Expression Profiling; Gene Expression Regulation, Plant; Methylation; Oryza; Plant Roots; Salt Stress; Salt Tolerance; Transcription Factors | 2022 |
m1A methylation modification patterns and metabolic characteristics in hepatocellular carcinoma.
Topics: Adenosine; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Methylation; Prognosis; RNA Processing, Post-Transcriptional | 2022 |
N
Topics: Adenosine; Animals; Cattle; Cell Line, Transformed; Cytokines; Epithelial Cells; Female; Hot Temperature; Mammary Glands, Animal; Mastitis; Methylation; Microbial Viability; Reactive Oxygen Species; RNA; RNA Processing, Post-Transcriptional; RNA, Messenger; Signal Transduction; Staphylococcal Infections; Staphylococcus aureus; Up-Regulation | 2022 |
Exploring m6A and m5C Epitranscriptomes upon Viral Infection: an Example with HIV.
Topics: 5-Methylcytosine; Adenosine; Epigenesis, Genetic; HIV Infections; Humans; Methylation; RNA; RNA, Messenger; Transcriptome; Virus Diseases | 2022 |
N6-Methyladenosine Regulator-Mediated Immue Patterns and Tumor Microenvironment Infiltration Characterization in Glioblastoma.
Topics: Adenosine; Glioblastoma; Humans; Methylation; Tumor Microenvironment | 2022 |
Mettl14-Mediated m6A Modification Is Essential for Germinal Center B Cell Response.
Topics: Adenosine; Animals; B-Lymphocytes; Cell Proliferation; Germinal Center; Intracellular Signaling Peptides and Proteins; Methylation; Methyltransferases; Mice | 2022 |
Primary sequence-assisted prediction of m
Topics: Adenosine; High-Throughput Nucleotide Sequencing; Methylation; Nanopores; RNA; Sequence Analysis, RNA | 2022 |
Methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit-induced long intergenic non-protein coding RNA 1833 N6-methyladenosine methylation promotes the non-small cell lung cancer progression via regulating heterogeneous nuclear ribon
Topics: Adenosine; Animals; Carcinoma, Non-Small-Cell Lung; Catalytic Domain; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Lung Neoplasms; Methylation; Methyltransferases; Mice; RNA, Long Noncoding | 2022 |
Dynamic N6-methyladenosine modification of lncRNA modulated by METTL3 during bacterial disease development in an echinoderm.
Topics: Adenosine; Animals; Bacterial Infections; Methylation; RNA, Long Noncoding | 2022 |
Roles of m6A modification in neurological diseases.
Topics: Adenosine; Depressive Disorder, Major; Epigenesis, Genetic; Humans; Methylation; RNA, Messenger | 2022 |
Role of RNA modifications in carcinogenesis and carcinogen damage response.
Topics: Adenosine; Carcinogenesis; Carcinogens; Humans; Methylation; RNA; RNA, Messenger | 2023 |
Global N
Topics: Adenosine; Animals; Methylation; RNA, Messenger; Sea Cucumbers; Stichopus; Ulcer; Vibrio; Vibrio Infections | 2022 |
N6-Methyladenosine dynamic changes and differential methylation in wheat grain development.
Topics: Adenosine; Edible Grain; Methylation; Starch; Triticum | 2022 |
The Correlation between Ferroptosis and m6A Methylation in Patients with Acute Kidney Injury.
Topics: Acute Kidney Injury; Adenosine; Amino Acid Transport System ASC; Ferroptosis; Humans; Methylation; Minor Histocompatibility Antigens | 2022 |
m6A Regulator-Mediated Tumour Infiltration and Methylation Modification in Cervical Cancer Microenvironment.
Topics: Adenosine; Female; Humans; Methylation; Prognosis; Tumor Microenvironment; Uterine Cervical Neoplasms | 2022 |
m6A Reader Igf2bp1 Regulates the Inflammatory Responses of Microglia by Stabilizing
Topics: Adenosine; Lipopolysaccharides; Methylation; Microglia; RNA, Messenger | 2022 |
Synthesis of RNA-cofactor conjugates and structural exploration of RNA recognition by an m6A RNA methyltransferase.
Topics: Adenosine; Catalytic Domain; Methylation; Methyltransferases; RNA | 2022 |
Identification and validation of the N6-methyladenosine RNA methylation regulator ZC3H13 as a novel prognostic marker and potential target for hepatocellular carcinoma.
Topics: Adenosine; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Methylation; Nuclear Proteins; Prognosis; RNA; RNA-Binding Proteins | 2022 |
[Comprehensive Analysis of the Relationship between m6A Methylation Patterns and Immune Microenvironment in Lung Adenocarcinoma].
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenosine; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Methylation; Tumor Microenvironment | 2022 |
Research progress on N6-methyladenosine in the human placenta.
Topics: Adenosine; Female; Humans; Methylation; Placenta; Pregnancy; RNA | 2022 |
A Novel Signature Based on m6A RNA Methylation Regulators Reveals Distinct Prognostic Subgroups and Associates with Tumor Immunity of Patients with Pancreatic Neuroendocrine Neoplasms.
Topics: Adenosine; Humans; Methylation; Multivariate Analysis; Neoplasms; Prognosis; RNA | 2022 |
Investigating the structural changes due to adenosine methylation of the Kaposi's sarcoma-associated herpes virus ORF50 transcript.
Topics: Adenosine; Cell Line; Endonucleases; Gene Expression Regulation, Viral; Herpesvirus 8, Human; Humans; Methylation; Open Reading Frames; RNA; Sarcoma, Kaposi | 2022 |
m6A Regulator-Mediated Methylation Modification Patterns and Characteristics in COVID-19 Patients.
Topics: Adenosine; COVID-19; Humans; Methylation; Reproducibility of Results; RNA | 2022 |
Bioinformatics Analysis of the Characteristics and Correlation of m6A Methylation in Breast Cancer Progression.
Topics: Adenosine; Breast Neoplasms; Computational Biology; Female; Humans; Methylation; RNA | 2022 |
Abnormal Expression of N6-Methyladenosine RNA Methylation Regulator IGF2BP3 in Colon Cancer Predicts a Poor Prognosis.
Topics: Adenocarcinoma; Adenosine; Colonic Neoplasms; Humans; Methylation; Prognosis; RNA; Tumor Microenvironment | 2022 |
Characterization of m6A Methylation Modification Patterns in Colorectal Cancer Determines Prognosis and Tumor Microenvironment Infiltration.
Topics: Adenosine; Colorectal Neoplasms; Humans; Methylation; Prognosis; Tumor Microenvironment | 2022 |
Comprehensive Analysis of the Expression and Prognostic Value of LMAN2 in HER2+ Breast Cancer.
Topics: Adenosine; Breast Neoplasms; Female; Humans; Mannose-Binding Lectins; Membrane Transport Proteins; Methylation; Prognosis | 2022 |
FTO Prevents Thyroid Cancer Progression by SLC7A11 m6A Methylation in a Ferroptosis-Dependent Manner.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Amino Acid Transport System y+; Animals; Epigenesis, Genetic; Ferroptosis; Methylation; Mice; Thyroid Neoplasms | 2022 |
Sequence-specific targeting of RNA.
Topics: Adenosine; Guanine; Methylation; Methyltransferases; RNA | 2022 |
N(6)-methyladenosine methylation-regulated polo-like kinase 1 cell cycle homeostasis as a potential target of radiotherapy in pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Adenosine; Cell Cycle; Cell Cycle Proteins; Homeostasis; Humans; Methylation; Methyltransferases; Pancreatic Neoplasms; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA-Binding Proteins | 2022 |
m6A regulators are differently expressed and correlated with immune response of pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Adenosine; Cell Line, Tumor; Datasets as Topic; Humans; Lymphocytes; Macrophages; Methylation; Neutrophils; Pancreatic Neoplasms; RNA Processing, Post-Transcriptional; RNA, Messenger | 2023 |
m 6 Aexpress-BHM: predicting m6A regulation of gene expression in multiple-groups context by a Bayesian hierarchical mixture model.
Topics: Adenosine; Bayes Theorem; Gene Expression Regulation; Methylation; RNA | 2022 |
Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex.
Topics: Adenosine; Methylation; Methyltransferases; RNA, Messenger; Viral Proteins | 2022 |
The function of Wtap in N
Topics: Adenosine; Animals; Cell Cycle Proteins; Methylation; Methyltransferases; Mice; RNA Splicing Factors; RNA, Messenger; Signal Transduction | 2022 |
Comprehensive analysis of RNA m6A methylation in pressure overload-induced cardiac hypertrophy.
Topics: Adenosine; Animals; Cardiomegaly; Methylation; Mice; RNA, Messenger; Transcriptome | 2022 |
m6A-related metabolism molecular classification with distinct prognosis and immunotherapy response in soft tissue sarcoma.
Topics: Adenosine; Humans; Immunotherapy; Methylation; Prognosis; Sarcoma; Tumor Microenvironment | 2022 |
m6A regulator-mediated methylation modification highlights immune infiltration patterns for predicting risk in hepatocellular carcinoma.
Topics: Adenosine; Carcinoma, Hepatocellular; Humans; Liver Neoplasms; Methylation; RNA; Tumor Microenvironment | 2023 |
N6-methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation.
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Carcinogenesis; Cell Line, Tumor; Colorectal Neoplasms; DNA-Binding Proteins; Humans; Methylation; RNA, Messenger; Transcription Factors | 2022 |
LRTCLS: low-rank tensor completion with Laplacian smoothing regularization for unveiling the post-transcriptional machinery of N6-methylation (m6A)-mediated diseases.
Topics: Adenosine; Alternative Splicing; Carcinoma, Non-Small-Cell Lung; COVID-19; Humans; Lung Neoplasms; Methylation; MicroRNAs; RNA-Binding Proteins; RNA, Circular | 2022 |
Comprehensive Analysis of N6-Methyladenosine RNA Methylation Regulators in the Diagnosis and Subtype Classification of Acute Myocardial Infarction.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Fragile X Mental Retardation Protein; Humans; Methylation; Methyltransferases; Myocardial Infarction; RNA | 2022 |
Cotton (
Topics: Adenosine; Chloroplasts; Gene Expression Regulation, Plant; Gossypium; Methylation; Methyltransferases; Plant Leaves; RNA, Messenger; RNA, Plant | 2022 |
Formation and removal of 1,N6-dimethyladenosine in mammalian transfer RNA.
Topics: Adenosine; Animals; Mammals; Methylation; RNA; RNA, Transfer | 2022 |
Mettl3-dependent m
Topics: Adenosine; Animals; Brain; Drosophila; Methylation; RNA, Messenger | 2022 |
Detection of m
Topics: Adenosine; Methylation; Nucleotides; RNA; Transcriptome | 2022 |
Adenosine N
Topics: Adenosine; Bupropion; Chromatin; Codon, Terminator; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C8; Formaldehyde; Histones; Humans; Methylation; Methyltransferases; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Retinoid X Receptors; RNA, Messenger | 2022 |
Novel Roles of RNA m6A Methylation Regulators in the Occurrence of Alzheimer's Disease and the Subtype Classification.
Topics: Adenosine; Alzheimer Disease; Computational Biology; Humans; Methylation; RNA | 2022 |
Analysis of N6-Methyladenosine RNA Methylation Regulators in Diagnosis and Distinct Molecular Subtypes of Ankylosing Spondylitis.
Topics: Adenosine; Humans; Methylation; RNA, Messenger; Spondylitis, Ankylosing | 2022 |
Characterization of m6A methylation modifications and tumor microenvironment infiltration in thyroid cancer.
Topics: Adenosine; Humans; Methylation; RNA; Thyroid Neoplasms; Tumor Microenvironment | 2023 |
FIONA1-mediated methylation of the 3'UTR of FLC affects FLC transcript levels and flowering in Arabidopsis.
Topics: 3' Untranslated Regions; Adenosine; Arabidopsis; Arabidopsis Proteins; Flowers; Gene Expression Regulation, Plant; Histones; MADS Domain Proteins; Methylation; Methyltransferases; Plants, Genetically Modified; RNA, Messenger | 2022 |
Methylation of N6 adenosine-related long noncoding RNA: effects on prognosis and treatment in 'driver-gene-negative' lung adenocarcinoma.
Topics: Adenocarcinoma; Adenosine; Humans; Lung; Lung Neoplasms; Methylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; RNA, Long Noncoding; Tumor Microenvironment | 2023 |
Chronic allergic asthma alters m6A epitranscriptomic tagging of mRNAs and lncRNAs in the lung.
Topics: Adenosine; Animals; Lung; Methylation; Mice; RNA, Long Noncoding; RNA, Messenger | 2022 |
IGF2BP2 serves as a core m6A regulator in head and neck squamous cell carcinoma.
Topics: Adenosine; Head and Neck Neoplasms; Humans; Methylation; RNA-Binding Proteins; RNA, Messenger; Squamous Cell Carcinoma of Head and Neck | 2022 |
CAPturAM, a Chemo-Enzymatic Strategy for Selective Enrichment and Detection of Physiological CAPAM-Targets.
Topics: Adenosine; Methylation; Methyltransferases; Nucleotides; RNA, Messenger | 2023 |
[Cluster classification and clinical prognostic modeling based on m6A RNA methylation regulators in liver cancer].
Topics: Adenosine; Humans; Liver Neoplasms; Methylation; Prognosis; RNA | 2022 |
The N
Topics: Adenosine; DNA; Erythroblasts; Erythropoiesis; Methylation; Methyltransferases; RNA, Messenger | 2022 |
RNA m6A methylation regulators in endometrial cancer (Review).
Topics: Adenosine; Endometrial Neoplasms; Female; Humans; Methylation; Methyltransferases; RNA; RNA, Messenger | 2022 |
Comprehensive Analysis and Functional Characteristics of Differential Expression of N6-Methyladenosine Methylation Modification in the Whole Transcriptome of Rheumatoid Arthritis.
Topics: Adenosine; Animals; Arthritis, Rheumatoid; Inflammation; Methylation; Phosphatidylinositol 3-Kinases; RNA, Messenger; Transcriptome | 2022 |
Integrative Transcriptomic Analysis Identify Potential m6A Pathway-Related Drugs That Inhibit Cancer Cell Proliferation.
Topics: Adenosine; Cell Proliferation; Gene Expression Profiling; Humans; Methylation; Neoplasms; Transcriptome | 2022 |
N
Topics: Adenosine; Methylation; Methyltransferases; T-Lymphocytes | 2023 |
Antibody-free photoelectrochemical strategy for simultaneous detection of methylated RNA, METTL3/METTL14 protein and MazF protein based on enhanced photoactivity of MoSe
Topics: Adenosine; Antibodies; Biosensing Techniques; Methylation; Methyltransferases; RNA | 2023 |
Diagnostic gene signatures and aberrant pathway activation based on m6A methylation regulators in rheumatoid arthritis.
Topics: Adenosine; Arthritis, Rheumatoid; Autoimmune Diseases; Consensus; Humans; Methylation | 2022 |
Transcriptome-wide profiling and quantification of N
Topics: Adenosine; Animals; Deamination; Methylation; Mice; Transcriptome | 2023 |
Shaping the landscape of N6-methyladenosine RNA methylation in Arabidopsis.
Topics: Adenosine; Arabidopsis; Humans; Methylation; Methyltransferases; RNA; RNA, Messenger | 2023 |
N6-methylation of RNA-bound adenosine regulator HNRNPC promotes vascular endothelial dysfunction in type 2 diabetes mellitus by activating the PSEN1-mediated Notch pathway.
Topics: Adenosine; Animals; Diabetes Mellitus, Type 2; Glucose; Heterogeneous-Nuclear Ribonucleoprotein Group C; Human Umbilical Vein Endothelial Cells; Humans; Methylation; Mice; Presenilin-1; RNA; Vascular Diseases | 2023 |
Transcriptome-wide high-throughput m
Topics: Abortion, Habitual; Adenosine; Female; Humans; Methylation; Phosphatidylinositol 3-Kinases; Pregnancy; Transcriptome | 2023 |
N6-methyladenosine methylation regulator FTO promotes oxidative stress and induces cell apoptosis in ovarian cancer.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Apoptosis; Female; Humans; Methylation; Mice; Mice, Nude; Ovarian Neoplasms; Oxidative Stress | 2022 |
N6-methyladenosine RNA Methylation Correlates with Immune Microenvironment and Immunotherapy Response of Melanoma.
Topics: Adenosine; Humans; Immunotherapy; Melanoma; Methylation; RNA; Tumor Microenvironment | 2023 |
Involvement of RNA methylation modification patterns mediated by m7G, m6A, m5C and m1A regulators in immune microenvironment regulation of Sjögren's syndrome.
Topics: 5-Methylcytosine; Adenosine; Eukaryotic Initiation Factor-3; Humans; Methylation; RNA; Sjogren's Syndrome | 2023 |
METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation.
Topics: Adenosine; Animals; Carcinoma, Pancreatic Ductal; DEAD-box RNA Helicases; Gemcitabine; Humans; Lung Neoplasms; Methylation; Methyltransferases; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA, Messenger | 2023 |
Evaluation of epitranscriptome-wide N6-methyladenosine differential analysis methods.
Topics: Adenosine; Humans; Methylation; RNA; Sequence Analysis, RNA; Transcriptome | 2023 |
m6A regulator-mediated RNA methylation modification patterns are involved in the regulation of the immune microenvironment in ischaemic cardiomyopathy.
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Cardiomyopathies; Fragile X Mental Retardation Protein; Humans; Methylation; Myocardial Ischemia; RNA | 2023 |
RBM33: A new regulator of N-6-methyladenosine (m
Topics: Adenosine; AlkB Homolog 5, RNA Demethylase; Methylation; RNA, Messenger | 2023 |
Direct m6A recognition by IMP1 underlays an alternative model of target selection for non-canonical methyl-readers.
Topics: Adenosine; Animals; Avian Proteins; Chickens; Methylation; Protein Processing, Post-Translational; Proteins; RNA; RNA-Binding Proteins | 2023 |
WTAP activates MAPK signaling through m6A methylation in VEGFA mRNA-mediated by YTHDC1 to promote colorectal cancer development.
Topics: Adenosine; Animals; Biological Assay; Colorectal Neoplasms; Humans; Methylation; Mice; Mice, Nude | 2023 |
N
Topics: Adenosine; Animals; Drosophila melanogaster; Insulin; Mammals; Methylation; Methyltransferases; RNA, Messenger | 2023 |
Alterations of the m
Topics: Adenosine; Cell Line; Epithelial-Mesenchymal Transition; Humans; Methylation; Retinal Pigment Epithelium; RNA-Seq; Transforming Growth Factor beta2 | 2023 |
Elucidating the clinical and immunological value of m6A regulator-mediated methylation modification patterns in adrenocortical carcinoma.
Topics: Adenosine; Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; DNA Copy Number Variations; Humans; Methylation; Tumor Microenvironment | 2023 |
Functional analysis of 3'-UTR hairpins supports a two-tiered model for posttranscriptional regulation of
Topics: 3' Untranslated Regions; Adenosine; Chromosomal Proteins, Non-Histone; Gene Expression Regulation; Humans; Methionine Adenosyltransferase; Methylation; Methyltransferases; RNA, Messenger; S-Adenosylmethionine | 2023 |
N6-methyladenosine methylation regulatory pattern of pulmonary lymphoepithelioma-like carcinoma based on exosomal transcriptome analysis.
Topics: Adenosine; Carcinoma, Squamous Cell; Gene Expression Profiling; Humans; Methylation; RNA, Messenger; Transcriptome | 2023 |
m1A Regulatory gene signatures are associated with certain immune cell compositions of the tumor microenvironment and predict survival in kidney renal clear cell carcinoma.
Topics: Adenosine; Carcinoma, Renal Cell; Cluster Analysis; Disease-Free Survival; Gene Expression Profiling; Genes, Regulator; Humans; Kidney Neoplasms; Methylation; Neoplastic Stem Cells; Prognosis; RNA Processing, Post-Transcriptional; Tumor Microenvironment | 2023 |
Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss.
Topics: Adenosine; Animals; Hearing Loss; Hippocampus; Methylation; Mice; Neomycin; RNA, Messenger | 2023 |
Association between ankylosing spondylitis and m6A methylation.
Topics: Adenosine; Gene Ontology; Humans; Inflammation; Methylation; Spondylitis, Ankylosing | 2023 |
Topics: Adenosine; Animals; Humans; Methylation; Methyltransferases; Mice; MicroRNAs; RNA, Messenger | 2023 |
Nitric oxide inhibits FTO demethylase activity to regulate N
Topics: Adenosine; Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Humans; Methylation; Nitric Oxide; RNA, Messenger | 2023 |
The role of m6A RNA methylation regulator in meningioma.
Topics: Adenosine; Humans; Meningeal Neoplasms; Meningioma; Methylation; Methyltransferases; RNA; RNA-Binding Proteins | 2023 |
Identifying N6-Methyladenosine Sites in HepG2 Cell Lines Using Oxford Nanopore Technology.
Topics: Adenosine; Cell Line; Methylation; Nanopores; Proteomics; Reproducibility of Results; RNA | 2023 |