Compounds > isoflurane

isoflurane and gamma-aminobutyric acid

isoflurane has been researched along with gamma-aminobutyric acid in 72 studies

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.78)18.7374
1990's18 (25.00)18.2507
2000's28 (38.89)29.6817
2010's20 (27.78)24.3611
2020's4 (5.56)2.80

Authors

AuthorsStudies
Brooks, PA; Harrison, NL; Jones, MV1
Isenberg, KE; Yang, J; Zorumski, CF1
el-Beheiry, H; Puil, E1
Brunner, E; Nakahiro, M; Narahashi, T; Yeh, JZ1
Fujita, S; Higashi, H; Shimoji, K; Yoshimura, M1
Desmonts, JM; Henzel, D; Lecharny, JB; Mantz, J; Salord, F1
Desmonts, JM; Henzel, D; Laudenbach, V; Lecharny, JB; Mantz, J; Peytavin, G1
Franks, NP; Hall, AC; Lieb, WR1
Nakashima, K; Todd, MM1
Amagasu, SM; Maclver, MB; Mikulec, AA; Monroe, FA1
Desmonts, JM; Henzel, D; Keita, H; Lecharny, JB; Mantz, J; Salord, F1
Ayata, C; Bosnjak, ZJ; Huang, PL; Hudetz, AG; Kampine, JP; Ma, J; Meng, W; Moskowitz, MA; Okamoto, H; Roman, RJ1
Adelsberger, H; Dudel, J; Franke, C; Wilde, J1
Finn, SE; Harrison, NL; Koltchine, VV; Krasowski, MD; Rick, CE; Ye, Q1
Berg-Johnsen, J; Haugstad, TS; Langmoen, IA; Larsen, M2
Banks, MI; Pearce, RA1
Fujimura, J; Hirota, K; Ito, Y; Masuda, A; Roth, SH1
Liachenko, S; Somogyi, GT; Tang, P; Xu, Y1
Ikemoto, Y; Nielsen, M; Yamashita, M; Yano, T1
de Sousa, SL; Dickinson, R; Franks, NP; Lieb, WR1
Franke, C; Hapfelmeier, G; Kochs, E; Neumahr, S; Scheller, M; Schneck, H1
Beyerle, M; Hapfelmeier, G; Haseneder, R; Kochs, E; Zieglgänsberger, W1
Adelsberger, H; Eder, M; Hapfelmeier, G; Haseneder, R; Kochs, E; Rammes, G; Zieglgänsberger, W1
Forman, SA; Scheller, M1
Alkire, MT; Haier, RJ1
Breese, GR; Criswell, HE; Knapp, DJ; Ming, Z; Mueller, RA1
Håberg, A; Haraldseth, O; Qu, H; Saether, O; Sonnewald, U; Unsgård, G1
Harrison, NL; Jenkins, A; Nishikawa, K; Paraskevakis, I1
Baron, N; Harrison, NL; Jenkins, A; Topf, N1
Hemmings, HC; Westphalen, RI3
Eger, EI; Harris, RA; Laster, MJ; Raines, DE; Sonner, JM; Stabernack, CR; Zhang, Y1
Banks, MI; Benkwitz, C; Pearce, RA1
Harrison, NL; Schofield, CM1
Ataka, T; Baba, H; Kohno, T; Okamoto, M; Wakai, A; Yamakura, T1
Dong, HL; Fukuda, S; Higuchi, T; Murata, E1
Alfille, P; Crosby, G; Culley, DJ; Dong, Y; Maeda, U; Tanzi, RE; Xie, Z1
Baron, NV; Blednov, YA; Boehm, SL; Borghese, CM; Dai, S; Harris, RA; Harrison, NL; Henderson, LA; Homanics, GE; Pearce, RA; Saad, A; Topf, N; Werner, DF1
Detsch, O; Kochs, E; Siemers, M; Vahle-Hinz, C1
Sonner, JM; Yang, L1
Goldstein, PA; Harrison, NL; Homanics, GE; Werner, DF; Ying, SW1
Baghdoyan, HA; Lydic, R; Vanini, G; Watson, CJ1
Brannigan, G; Butts, CA; Dmochowski, IJ; Eckenhoff, RG; Klein, ML; Pearce, RA; Saad, AA; Venkatachalan, SP; Xi, J1
Antognini, JF; Atherley, RJ; Jinks, SL; Kim, J; Kungys, G1
Amzica, F; Chever, O; Ferron, JF; Kroeger, D1
Dow-Edwards, D; Siegal, N1
Hirota, K; Roth, SH; Sasaki, R; Yamazaki, M1
Ilkiw, JE; Pypendop, BH; Reid, P1
Borghese, CM; Eger, EI; Fanselow, MS; Harris, RA; Harrison, NL; Homanics, GE; Iyer, S; Jia, F; McCracken, ML; Oh, I; Rau, V; Sonner, JM; Swihart, A; Werner, DF1
Borghese, CM; Harris, RA; McCracken, ML; Trudell, JR1
Guo, X; Li, M; Ma, D; Maze, M; Pac-Soo, C; Shu, Y; Zhou, ZW1
Akaike, N; Kotani, N; Ogawa, SK; Shin, MC; Tanaka, E1
Campbell, LL; Edmands, SD; Hall, AC; Hokenson, KE; Kim, SA; McKeon, JE; Sherrill, H; Stackpole, EE; Suarez, C; Tyson, JA1
Baxter, MG; Crosby, G; Culley, DJ; Keel, PK; Palanisamy, A; Xie, Z1
Nishikawa, K1
Daniels, K; Hemmings, HC; Kwak, NB; Westphalen, RI1
Jin, XG; Li, SY; Luo, AL; Shi, QY; Tan, L; Wang, JT; Xiang, Q; Zhao, YL1
Wei, H1
Boruta, DT; Golder, FJ; Sotgiu, G1
Shadan, S1
Lecker, I; Mazer, CD; Orser, BA; Peterson, M; Romaschin, AD; Wang, DS1
Danzer, SC; Hughes, EA; Istaphanous, GK; Loepke, AW; McAuliffe, JJ; McCann, JC; Nan, X; Ward, CG1
Baghdoyan, HA; Lydic, R; Nemanis, K; Vanini, G1
Avramescu, S; Horner, RL; Lecker, I; Mesbah-Oskui, L; Orser, BA; Penna, A; To, WT; Wang, DS; Whissell, PD1
Gao, H; Huang, DX; Song, ZG; Wang, Q; Wang, X; Wang, ZP1
Morgenstern, R; Netzhammer, N; Seidemann, T; Spies, C; Wernecke, KD1
Hao, X; Li, Y; Liu, J; Ou, M; Yang, H; Yang, Y; Zhang, D; Zhao, W; Zhou, C; Zhu, T1
Lor, C; Pearce, RA; Perouansky, M1
Dong, H; Gao, Z; Guo, J; Hu, J; Li, H; Ran, M; Sun, W; Wang, D; Zhang, X; Zhao, S1
Hemmings, HC; Speigel, IA1

Reviews

2 review(s) available for isoflurane and gamma-aminobutyric acid

ArticleYear
[Roles of glutamatergic and GABAergic nervous system in hypnotic and analgesic actions of general anesthetics].
    Masui. The Japanese journal of anesthesiology, 2011, Volume: 60, Issue:5

    Topics: Analgesics; Anesthesia, General; Anesthetics, General; Electroencephalography; Electrophysiological Phenomena; gamma-Aminobutyric Acid; Glutamates; Humans; Hypnotics and Sedatives; Hypothalamus; Isoflurane; Ketamine; Methyl Ethers; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Sevoflurane

2011
The Effects of General Anesthetics on Synaptic Transmission.
    Current neuropharmacology, 2020, Volume: 18, Issue:10

    Topics: Anesthetics, General; Animals; Calcium Channels; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Isoflurane; Molecular Structure; Neuronal Plasticity; Neurons; Neurotransmitter Agents; Sodium; Synaptic Transmission; Voltage-Gated Sodium Channels

2020

Other Studies

70 other study(ies) available for isoflurane and gamma-aminobutyric acid

ArticleYear
Enhancement of gamma-aminobutyric acid-activated Cl- currents in cultured rat hippocampal neurones by three volatile anaesthetics.
    The Journal of physiology, 1992, Volume: 449

    Topics: Animals; Chlorides; Enflurane; gamma-Aminobutyric Acid; Halothane; Hippocampus; Isoflurane; Membrane Potentials; Neurons; Rats; Receptors, GABA-A

1992
Volatile anesthetics gate a chloride current in postnatal rat hippocampal neurons.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1992, Feb-01, Volume: 6, Issue:3

    Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anesthetics; Animals; Animals, Newborn; Bicuculline; Chlorine; Chromatography, Gas; Culture Techniques; Dose-Response Relationship, Drug; Electrophysiology; Enflurane; gamma-Aminobutyric Acid; Halothane; Hippocampus; Ion Channel Gating; Isoflurane; Neurons; Picrotoxin; Rats; Sesterterpenes; Strychnine

1992
Anaesthetic suppression of transmitter actions in neocortex.
    British journal of pharmacology, 1990, Volume: 101, Issue:1

    Topics: Acetylcholine; Alfaxalone Alfadolone Mixture; Anesthetics; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glutamates; Guinea Pigs; In Vitro Techniques; Isoflurane; Membrane Potentials; N-Methylaspartate; Neurotransmitter Agents

1990
General anesthetics modulate GABA receptor channel complex in rat dorsal root ganglion neurons.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1989, Volume: 3, Issue:7

    Topics: Anesthetics; Animals; Cells, Cultured; Chloride Channels; Chlorides; Electric Conductivity; Enflurane; gamma-Aminobutyric Acid; Ganglia, Spinal; Halothane; Isoflurane; Membrane Proteins; Neurons; Rats; Receptors, GABA-A

1989
Selective depression of hippocampal inhibitory postsynaptic potentials and spontaneous firing by volatile anesthetics.
    Brain research, 1985, Aug-12, Volume: 340, Issue:2

    Topics: Anesthetics; Animals; Brain Chemistry; Electric Stimulation; Enflurane; Evoked Potentials; gamma-Aminobutyric Acid; Halothane; Hippocampus; In Vitro Techniques; Isoflurane; Male; Neural Inhibition; Rats; Rats, Inbred Strains; Time Factors; Volatilization

1985
Effects of thiopental, halothane and isoflurane on the calcium-dependent and -independent release of GABA from striatal synaptosomes in the rat.
    Brain research, 1995, Jan-30, Volume: 670, Issue:2

    Topics: Anesthetics; Animals; Calcium; Corpus Striatum; gamma-Aminobutyric Acid; Halothane; Isoflurane; Male; Membrane Potentials; Nipecotic Acids; Proline; Rats; Rats, Sprague-Dawley; Synaptosomes; Thiopental; Veratridine

1995
Anesthetics affect the uptake but not the depolarization-evoked release of GABA in rat striatal synaptosomes.
    Anesthesiology, 1995, Volume: 82, Issue:2

    Topics: Anesthetics; Animals; Biological Transport; Clonidine; Corpus Striatum; Enflurane; Etomidate; gamma-Aminobutyric Acid; Halothane; In Vitro Techniques; Isoflurane; Ketamine; Male; Nipecotic Acids; Potassium Chloride; Proline; Propofol; Rats; Rats, Sprague-Dawley; Synaptosomes; Thiopental

1995
Stereoselective and non-stereoselective actions of isoflurane on the GABAA receptor.
    British journal of pharmacology, 1994, Volume: 112, Issue:3

    Topics: Anesthesia, General; Animals; Cerebellum; Chloride Channels; gamma-Aminobutyric Acid; In Vitro Techniques; Isoflurane; Patch-Clamp Techniques; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Stereoisomerism

1994
Effects of hypothermia, pentobarbital, and isoflurane on postdepolarization amino acid release during complete global cerebral ischemia.
    Anesthesiology, 1996, Volume: 85, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Aspartic Acid; Brain Ischemia; Calcium; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hypnotics and Sedatives; Hypothermia, Induced; Isoflurane; Male; Pentobarbital; Rats; Rats, Sprague-Dawley

1996
Volatile anesthetics depress glutamate transmission via presynaptic actions.
    Anesthesiology, 1996, Volume: 85, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Calcium; Depression, Chemical; Electrophysiology; gamma-Aminobutyric Acid; Glutamic Acid; Halothane; Hippocampus; In Vitro Techniques; Ion Transport; Isoflurane; Male; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Temperature

1996
Halothane and isoflurane differentially affect the regulation of dopamine and gamma-aminobutyric acid release mediated by presynaptic acetylcholine receptors in the rat striatum.
    Anesthesiology, 1997, Volume: 86, Issue:3

    Topics: Acetylcholine; Anesthetics, Inhalation; Animals; Corpus Striatum; Dopamine; gamma-Aminobutyric Acid; Halothane; Isoflurane; Male; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Nicotinic; Stimulation, Chemical

1997
Isoflurane-induced cerebral hyperemia in neuronal nitric oxide synthase gene deficient mice.
    Anesthesiology, 1997, Volume: 86, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Brain; Cerebrovascular Circulation; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Hyperemia; Isoflurane; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine

1997
Multiple mechanisms of block by the anesthetic isoflurane of a gamma-aminobutyric acid activated chloride channel in crayfish.
    Journal of comparative physiology. A, Sensory, neural, and behavioral physiology, 1998, Volume: 182, Issue:1

    Topics: Anesthetics; Animals; Astacoidea; Chloride Channels; Dose-Response Relationship, Drug; Electric Conductivity; gamma-Aminobutyric Acid; Isoflurane; Kinetics; Patch-Clamp Techniques

1998
Propofol and other intravenous anesthetics have sites of action on the gamma-aminobutyric acid type A receptor distinct from that for isoflurane.
    Molecular pharmacology, 1998, Volume: 53, Issue:3

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Binding Sites; Cells, Cultured; Drug Synergism; Etomidate; gamma-Aminobutyric Acid; Humans; Isoflurane; Methohexital; Mutagenesis, Site-Directed; Propofol; Receptors, GABA-A

1998
The effect of isoflurane on brain amino acid release and tissue content induced by energy deprivation.
    Journal of neurosurgical anesthesiology, 1998, Volume: 10, Issue:3

    Topics: Amino Acids; Anesthetics, Inhalation; Animals; Arginine; Culture Media; Culture Techniques; Energy Metabolism; gamma-Aminobutyric Acid; Glucose; Glutamates; Glutamine; Hippocampus; Isoflurane; Male; Neuroprotective Agents; Nitrogen; Rats; Rats, Wistar; Taurine

1998
Effect of isoflurane on release and uptake of gamma-aminobutyric acid from rat cortical synaptosomes.
    British journal of anaesthesia, 1998, Volume: 80, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Calcium; Cerebral Cortex; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoflurane; Potassium; Rats; Rats, Wistar; Synaptosomes

1998
Dual actions of volatile anesthetics on GABA(A) IPSCs: dissociation of blocking and prolonging effects.
    Anesthesiology, 1999, Volume: 90, Issue:1

    Topics: Algorithms; Anesthetics, Inhalation; Animals; Electric Stimulation; Enflurane; Evoked Potentials; gamma-Aminobutyric Acid; Halothane; Hippocampus; In Vitro Techniques; Isoflurane; Neural Inhibition; Patch-Clamp Techniques; Pyramidal Cells; Rats; Receptors, GABA-A; Synapses

1999
GABAergic mechanisms in the action of general anesthetics.
    Toxicology letters, 1998, Nov-23, Volume: 100-101

    Topics: Anesthetics, General; Anesthetics, Intravenous; Animals; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Isoflurane; Male; Rats; Rats, Wistar; Synaptic Transmission; Thiopental

1998
Concentration-dependent isoflurane effects on depolarization-evoked glutamate and GABA outflows from mouse brain slices.
    British journal of pharmacology, 1999, Volume: 127, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Brain; Chromatography, High Pressure Liquid; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Isoflurane; Male; Mice; Neurotransmitter Uptake Inhibitors; Potassium Chloride; Spectrometry, Fluorescence; Synapses

1999
Effects of isoflurane and hexafluorodiethyl ether on human recombinant GABA(A) receptors expressed in Sf9 cells.
    European journal of pharmacology, 1999, Aug-06, Volume: 378, Issue:2

    Topics: Anesthetics, Inhalation; Cells, Cultured; Convulsants; DNA, Complementary; Dose-Response Relationship, Drug; Drug Interactions; Flurothyl; gamma-Aminobutyric Acid; Humans; Isoflurane; Patch-Clamp Techniques; Receptors, GABA-A; Recombinant Proteins

1999
Contrasting synaptic actions of the inhalational general anesthetics isoflurane and xenon.
    Anesthesiology, 2000, Volume: 92, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Cells, Cultured; Electrophysiology; gamma-Aminobutyric Acid; Glutamic Acid; Isoflurane; Male; Neurons; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission; Xenon

2000
Dual action of isoflurane on the gamma-aminobutyric acid (GABA)-mediated currents through recombinant alpha(1)beta(2)gamma(2L)-GABA(A)-receptor channels.
    Anesthesia and analgesia, 2000, Volume: 90, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Cell Line; Chloride Channels; Electrophysiology; gamma-Aminobutyric Acid; Humans; Isoflurane; Patch-Clamp Techniques; Rats; Receptors, GABA-A; Recombinant Proteins; Transfection

2000
Coadministered nitrous oxide enhances the effect of isoflurane on GABAergic transmission by an increase in open-channel block.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 298, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Cell Line; Drug Combinations; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Isoflurane; Kidney; Nitrous Oxide; Rats; Receptors, GABA-A

2001
Isoflurane slows inactivation kinetics of rat recombinant alpha1beta2gamma2L GABA(A) receptors: enhancement of GABAergic transmission despite an open-channel block.
    Neuroscience letters, 2001, Jul-13, Volume: 307, Issue:2

    Topics: Anesthetics, Inhalation; Brain; Cells, Cultured; Drug Interactions; gamma-Aminobutyric Acid; Humans; Ion Channels; Isoflurane; Membrane Potentials; Models, Neurological; Neural Inhibition; Neurons; Patch-Clamp Techniques; Pharmacokinetics; Receptors, GABA-A; Recombinant Proteins; Synaptic Transmission

2001
The gamma subunit determines whether anesthetic-induced leftward shift is altered by a mutation at alpha1S270 in alpha1beta2gamma2L GABA(A) receptors.
    Anesthesiology, 2001, Volume: 95, Issue:1

    Topics: Amino Acid Substitution; Anesthetics, Inhalation; Animals; DNA, Complementary; Electrophysiology; gamma-Aminobutyric Acid; Humans; Isoflurane; Kinetics; Microelectrodes; Oocytes; Receptors, GABA-A; Recombinant Proteins; Xenopus

2001
Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane.
    British journal of anaesthesia, 2001, Volume: 86, Issue:5

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Brain; GABA Agonists; gamma-Aminobutyric Acid; Glucose; Humans; Isoflurane; Male; Propofol; Receptors, GABA-A; Receptors, Neurotransmitter; Retrospective Studies; Tomography, Emission-Computed

2001
Differential modulation of GABA- and NMDA-gated currents by ethanol and isoflurane in cultured rat cerebral cortical neurons.
    Brain research, 2001, Nov-30, Volume: 920, Issue:1-2

    Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Cells, Cultured; Central Nervous System Depressants; Cerebral Cortex; Dose-Response Relationship, Drug; Electrophysiology; Ethanol; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Ion Channel Gating; Isoflurane; N-Methylaspartate; Neurons; Patch-Clamp Techniques; Rats; Reflex

2001
Differences in neurotransmitter synthesis and intermediary metabolism between glutamatergic and GABAergic neurons during 4 hours of middle cerebral artery occlusion in the rat: the role of astrocytes in neuronal survival.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2001, Volume: 21, Issue:12

    Topics: Acetate-CoA Ligase; Alanine; Anesthetics, Inhalation; Animals; Aspartic Acid; Astrocytes; Blood Glucose; Carbon Isotopes; Cell Communication; Cell Survival; Citric Acid Cycle; Energy Metabolism; Frontal Lobe; gamma-Aminobutyric Acid; Glucose; Glutamic Acid; Glutamine; Infarction, Middle Cerebral Artery; Isoflurane; Magnetic Resonance Spectroscopy; Male; Neostriatum; Neurons; Parietal Lobe; Rats; Rats, Wistar

2001
Volatile anesthetic actions on the GABAA receptors: contrasting effects of alpha 1(S270) and beta 2(N265) point mutations.
    Neuropharmacology, 2002, Volume: 42, Issue:3

    Topics: Amino Acid Sequence; Anesthetics, Inhalation; Asparagine; Cell Line; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Halothane; Humans; Isoflurane; Point Mutation; Receptors, GABA-A; Serine

2002
Effects of isoflurane on gamma-aminobutyric acid type A receptors activated by full and partial agonists.
    Anesthesiology, 2003, Volume: 98, Issue:2

    Topics: Anesthetics, Inhalation; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Electrophysiology; GABA Agonists; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Isoflurane; Mutagenesis, Site-Directed; Mutation; Patch-Clamp Techniques; Piperidines; Receptors, GABA-A; Transfection

2003
Selective depression by general anesthetics of glutamate versus GABA release from isolated cortical nerve terminals.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:3

    Topics: 4-Aminopyridine; Anesthetics, General; Animals; gamma-Aminobutyric Acid; Glutamic Acid; In Vitro Techniques; Isoflurane; Male; Potassium; Rats; Rats, Sprague-Dawley; Synaptosomes

2003
Gamma-aminobutyric acidA receptors do not mediate the immobility produced by isoflurane.
    Anesthesia and analgesia, 2004, Volume: 99, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Chromatography, Gas; Cyclopropanes; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Spinal; Isoflurane; Male; Motor Activity; Oocytes; Picrotoxin; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Xenon; Xenopus

2004
Influence of GABAA receptor gamma2 splice variants on receptor kinetics and isoflurane modulation.
    Anesthesiology, 2004, Volume: 101, Issue:4

    Topics: Anesthetics, Inhalation; Cells, Cultured; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Isoflurane; Kinetics; Protein Subunits; Receptors, GABA-A

2004
Transmembrane residues define the action of isoflurane at the GABAA receptor alpha-3 subunit.
    Brain research, 2005, Jan-25, Volume: 1032, Issue:1-2

    Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Cell Line; Dose-Response Relationship, Drug; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoflurane; Membrane Potentials; Molecular Sequence Data; Mutagenesis, Site-Directed; Patch-Clamp Techniques; Picrotoxin; Propofol; Protein Structure, Tertiary; Protein Subunits; Receptors, GABA-A; Transfection

2005
Action of isoflurane on the substantia gelatinosa neurons of the adult rat spinal cord.
    Anesthesiology, 2005, Volume: 102, Issue:2

    Topics: Animals; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamates; In Vitro Techniques; Isoflurane; Neurons; Rats; Spinal Cord; Spinal Nerve Roots; Substantia Gelatinosa; Synapses; Synaptic Transmission

2005
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: 4-aminopyridine-evoked release.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:1

    Topics: 4-Aminopyridine; Anesthetics, Inhalation; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Enflurane; gamma-Aminobutyric Acid; Glutamic Acid; Halothane; In Vitro Techniques; Isoflurane; Male; Nerve Endings; Neurotransmitter Agents; Potassium Channel Blockers; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Tetrodotoxin

2006
Volatile anesthetic effects on glutamate versus GABA release from isolated rat cortical nerve terminals: basal release.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:1

    Topics: Algorithms; Anesthetics, Inhalation; Animals; Cerebral Cortex; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enflurane; gamma-Aminobutyric Acid; Glutamic Acid; Halothane; In Vitro Techniques; Isoflurane; L-Lactate Dehydrogenase; Male; Nerve Endings; Neurotransmitter Agents; Presynaptic Terminals; Rats; Rats, Sprague-Dawley

2006
Excitatory and inhibitory actions of isoflurane on the cholinergic ascending arousal system of the rat.
    Anesthesiology, 2006, Volume: 104, Issue:1

    Topics: Acetylcholine; Anesthetics, Inhalation; Animals; Arousal; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; gamma-Aminobutyric Acid; Glutamic Acid; Isoflurane; Male; Microdialysis; Parasympathetic Nervous System; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate

2006
The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels.
    Anesthesiology, 2006, Volume: 104, Issue:5

    Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anesthetics, Inhalation; Apoptosis; Blotting, Western; Brain Neoplasms; Caspases; Cell Line, Tumor; Cell Survival; Drug Synergism; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; gamma-Aminobutyric Acid; Glioma; Humans; Isoflurane; Nerve Tissue Proteins; Triglycerides

2006
An isoflurane- and alcohol-insensitive mutant GABA(A) receptor alpha(1) subunit with near-normal apparent affinity for GABA: characterization in heterologous systems and production of knockin mice.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 319, Issue:1

    Topics: Animals; Cells, Cultured; Ethanol; Female; GABA Modulators; gamma-Aminobutyric Acid; Humans; Isoflurane; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Mutation; Receptors, GABA-A; Structure-Activity Relationship; Xenopus; Zinc

2006
Contributions of GABAergic and glutamatergic mechanisms to isoflurane-induced suppression of thalamic somatosensory information transfer.
    Experimental brain research, 2007, Volume: 176, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Blood Pressure; Data Interpretation, Statistical; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Heart Rate; Iontophoresis; Isoflurane; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Ventral Thalamic Nuclei

2007
The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:3

    Topics: 3-Hydroxybutyric Acid; Ammonium Chloride; Anesthetics; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Ethanol; Female; gamma-Aminobutyric Acid; Glycine; Humans; Isoflurane; Membrane Potentials; Oocytes; Point Mutation; Propofol; Rats; Receptors, GABA-A; Receptors, Glycine; Sodium Dodecyl Sulfate; Structure-Activity Relationship; Xenopus laevis

2008
Isoflurane modulates excitability in the mouse thalamus via GABA-dependent and GABA-independent mechanisms.
    Neuropharmacology, 2009, Volume: 56, Issue:2

    Topics: 4-Aminopyridine; Action Potentials; Alanine; Anesthetics, Inhalation; Animals; Biophysics; Dose-Response Relationship, Drug; GABA Agonists; gamma-Aminobutyric Acid; Histidine; Inhibitory Postsynaptic Potentials; Isoflurane; Leucine; Mice; Mice, Transgenic; Mutation; Neural Inhibition; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Pyridazines; Receptors, GABA-A; Serine; Thalamus; Time Factors

2009
Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia.
    Anesthesiology, 2008, Volume: 109, Issue:6

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Cats; gamma-Aminobutyric Acid; Immobility Response, Tonic; Isoflurane; Male; Pons; Rats; Rats, Sprague-Dawley; Respiration; Reticular Formation; Synaptic Transmission

2008
Identification of a fluorescent general anesthetic, 1-aminoanthracene.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Apr-21, Volume: 106, Issue:16

    Topics: Anesthetics, General; Animals; Anthracenes; Apoferritins; Binding Sites; Chloride Channels; Fluorescence; Fluorescent Dyes; gamma-Aminobutyric Acid; Horses; Ion Channel Gating; Isoflurane; Larva; Microscopy, Confocal; Neurons; Propofol; Protein Structure, Secondary; Reflex, Startle; Spectrometry, Fluorescence; Temperature; Xenopus laevis

2009
Propofol produces immobility via action in the ventral horn of the spinal cord by a GABAergic mechanism.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:5

    Topics: Action Potentials; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Anterior Horn Cells; Decerebrate State; GABA Antagonists; gamma-Aminobutyric Acid; Immobilization; Isoflurane; Male; Movement; Pain Threshold; Picrotoxin; Posterior Horn Cells; Propofol; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2009
Cortical inhibition during burst suppression induced with isoflurane anesthesia.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Aug-05, Volume: 29, Issue:31

    Topics: Amino Acid Transport System X-AG; Anesthesia; Anesthetics; Animals; Cats; Central Nervous System Agents; Cerebral Cortex; Chlorides; Electroencephalography; Excitatory Postsynaptic Potentials; Extracellular Space; gamma-Aminobutyric Acid; Inhibitory Postsynaptic Potentials; Isoflurane; Kainic Acid; Neural Pathways; Neuroglia; Neurons; Thalamus

2009
Isoflurane anesthesia interferes with the expression of cocaine-induced sensitization in female rats.
    Neuroscience letters, 2009, Oct-16, Volume: 464, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Body Weight; Cocaine; Estrous Cycle; Female; gamma-Aminobutyric Acid; Glutamic Acid; Isoflurane; Male; Motor Activity; Rats; Rats, Sprague-Dawley; Sex Factors; Stereotyped Behavior

2009
Presynaptic actions of general anesthetics are responsible for frequency-dependent modification of synaptic transmission in the rat hippocampal CA1.
    Anesthesia and analgesia, 2010, Jun-01, Volume: 110, Issue:6

    Topics: Anesthetics, General; Animals; Axons; CA1 Region, Hippocampal; Central Nervous System; Dose-Response Relationship, Drug; Electric Stimulation; Electrophysiology; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Isoflurane; Male; Methyl Ethers; Neurotransmitter Agents; Neurotransmitter Uptake Inhibitors; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Presynaptic; Sevoflurane; Synaptic Transmission; Thiopental

2010
The effects of intravenous gabapentin administration on the minimum alveolar concentration of isoflurane in cats.
    Anesthesia and analgesia, 2010, Volume: 111, Issue:3

    Topics: Amines; Analgesics; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Blood Pressure; Body Temperature; Cats; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Drug Interactions; Gabapentin; gamma-Aminobutyric Acid; Injections, Intravenous; Isoflurane; Pulmonary Alveoli; Tandem Mass Spectrometry

2010
Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 336, Issue:1

    Topics: Anesthetics, Inhalation; Animals; Conditioning, Psychological; Drug Resistance; Fear; Female; gamma-Aminobutyric Acid; Gene Knock-In Techniques; Humans; Isoflurane; Mice; Mice, Inbred C57BL; Rats; Receptors, GABA-A; Recombinant Proteins; Xenopus laevis

2011
A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:3

    Topics: 1-Butanol; 1-Octanol; Alcohols; Amino Acid Substitution; Anesthetics; Animals; Asparagine; Binding Sites; Cysteine; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Female; gamma-Aminobutyric Acid; Humans; Ion Channel Gating; Isoflurane; Oocytes; Patch-Clamp Techniques; Rats; Receptors, GABA-A; RNA, Complementary; Thiosulfonic Acids; Xenopus laevis

2010
The glutaminergic, GABAergic, dopaminergic but not cholinergic neurons are susceptible to anaesthesia-induced cell death in the rat developing brain.
    Neuroscience, 2011, Feb-03, Volume: 174

    Topics: Acetylcholine; Anesthesia; Anesthetics, Combined; Animals; Apoptosis; Brain; CA1 Region, Hippocampal; Caspase 3; Dopamine; gamma-Aminobutyric Acid; Glutamic Acid; Gyrus Cinguli; Isoflurane; Neurons; Nitrous Oxide; Prosencephalon; Rats; Rats, Sprague-Dawley; Substantia Nigra

2011
Volatile anesthetic effects on isolated GABA synapses and extrasynaptic receptors.
    Neuropharmacology, 2011, Volume: 60, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Dose-Response Relationship, Drug; Electrophysiology; Enflurane; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Isoflurane; Methyl Ethers; Miniature Postsynaptic Potentials; Neurons; Rats; Rats, Wistar; Receptors, GABA-A; Sevoflurane; Synapses; Synaptic Transmission

2011
Assessment of general anaesthetic cytotoxicity in murine cortical neurones in dissociated culture.
    Toxicology, 2011, Apr-28, Volume: 283, Issue:1

    Topics: Anesthetics, General; Animals; Animals, Newborn; Cell Survival; Cerebral Cortex; gamma-Aminobutyric Acid; Isoflurane; Ketamine; L-Lactate Dehydrogenase; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Microtubule-Associated Proteins; N-Methylaspartate; Neurons; Nitrous Oxide

2011
Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults.
    Anesthesiology, 2011, Volume: 114, Issue:3

    Topics: Anesthesia; Anesthetics, Inhalation; Animals; Anxiety; Behavior, Animal; Blood Pressure; Body Weight; Brain; Female; gamma-Aminobutyric Acid; Isoflurane; Male; Maze Learning; Motor Activity; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Recognition, Psychology

2011
Regional differences in the effects of isoflurane on neurotransmitter release.
    Neuropharmacology, 2011, Volume: 61, Issue:4

    Topics: Animals; Cerebral Cortex; Corpus Striatum; gamma-Aminobutyric Acid; Glutamic Acid; Hippocampus; Isoflurane; Male; Nerve Endings; Neurotransmitter Agents; Rats; Rats, Sprague-Dawley; Spinal Cord

2011
GABAergic excitotoxicity injury of the immature hippocampal pyramidal neurons' exposure to isoflurane.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Blotting, Western; Calcium; Calcium Channels; Calcium Signaling; Caspase 3; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; Hippocampus; Isoflurane; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Ryanodine Receptor Calcium Release Channel

2011
The role of calcium dysregulation in anesthetic-mediated neurotoxicity.
    Anesthesia and analgesia, 2011, Volume: 113, Issue:5

    Topics: Anesthetics, Inhalation; Animals; Calcium Signaling; Cell Differentiation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; gamma-Aminobutyric Acid; Hippocampus; Isoflurane; Ketamine; Neurons; Pregnancy; Pyramidal Cells

2011
Effects of intraperitoneal administration of gabapentin on the minimum alveolar concentration of isoflurane in adult male rats.
    Laboratory animals, 2012, Volume: 46, Issue:2

    Topics: Amines; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Anticonvulsants; Cyclohexanecarboxylic Acids; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoflurane; Male; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley

2012
Neuroscience: Sleep to oblivion.
    Nature, 2012, Nov-01, Volume: 491, Issue:7422

    Topics: Anesthesia; Anesthetics; Animals; gamma-Aminobutyric Acid; Humans; Hypothalamus; Isoflurane; Mice; Sleep; Wakefulness

2012
Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Animals; Anticonvulsants; Aprotinin; Binding, Competitive; Cells, Cultured; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Humans; In Vitro Techniques; Inhibitory Concentration 50; Inhibitory Postsynaptic Potentials; Isoflurane; Membrane Potentials; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Middle Aged; Neurons; Patch-Clamp Techniques; Propofol; Protein Binding; Receptors, GABA-A; Receptors, Glycine; Seizures; Spinal Cord; Synaptic Transmission; Tranexamic Acid; Young Adult

2012
Characterization and quantification of isoflurane-induced developmental apoptotic cell death in mouse cerebral cortex.
    Anesthesia and analgesia, 2013, Volume: 116, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Caspase 3; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Female; gamma-Aminobutyric Acid; Glial Fibrillary Acidic Protein; Glutamate Decarboxylase; Immunohistochemistry; Interneurons; Isoflurane; Male; Mice; Mice, Inbred C57BL; Neurons; Phenotype; S100 Proteins

2013
GABAergic transmission in rat pontine reticular formation regulates the induction phase of anesthesia and modulates hyperalgesia caused by sleep deprivation.
    The European journal of neuroscience, 2014, Volume: 40, Issue:1

    Topics: 3-Mercaptopropionic Acid; Anesthetics, General; Animals; Consciousness; GABA Agents; GABA Uptake Inhibitors; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Isoflurane; Male; Nipecotic Acids; Nociception; Pain Threshold; Pontine Tegmentum; Propofol; Rats, Sprague-Dawley; Reflex, Righting; Sleep Deprivation; Time Factors

2014
Inflammation Increases Neuronal Sensitivity to General Anesthetics.
    Anesthesiology, 2016, Volume: 124, Issue:2

    Topics: Anesthetics, General; Anesthetics, Inhalation; Animals; Cells, Cultured; Cerebral Cortex; Etomidate; gamma-Aminobutyric Acid; Hypnotics and Sedatives; Inflammation; Isoflurane; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Up-Regulation

2016
A single nucleotide polymorphism in GABAA receptor isoforms is potentially responsible for isoflurane sensitivity in mice.
    Genetics and molecular research : GMR, 2016, Jun-10, Volume: 15, Issue:2

    Topics: Anesthetics, Inhalation; Animals; Brain; Drug Resistance; gamma-Aminobutyric Acid; High-Throughput Nucleotide Sequencing; Isoflurane; Mice; Polymorphism, Single Nucleotide; Protein Isoforms; Receptors, GABA-A

2016
Influence of Volatile Anesthesia on the Release of Glutamate and other Amino Acids in the Nucleus Accumbens in a Rat Model of Alcohol Withdrawal: A Pilot Study.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: Amino Acids; Anesthesia, Inhalation; Animals; Arginine; Aspartic Acid; Desflurane; Disease Models, Animal; Feeding Behavior; gamma-Aminobutyric Acid; Glutamic Acid; Isoflurane; Male; Microdialysis; Nucleus Accumbens; Pilot Projects; Rats, Wistar; Substance Withdrawal Syndrome; Time Factors; Volatilization

2017
Isoflurane Potentiation of GABA
    International journal of molecular sciences, 2020, Dec-15, Volume: 21, Issue:24

    Topics: Anesthetics, Inhalation; Animals; Etomidate; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Isoflurane; Mice, Transgenic; Patch-Clamp Techniques; Point Mutation; Propofol; Receptors, GABA-A; Recombinant Proteins

2020
Cell-type-specific imaging of neurotransmission reveals a disrupted excitatory-inhibitory cortical network in isoflurane anaesthesia.
    EBioMedicine, 2021, Volume: 65

    Topics: Anesthetics, Inhalation; Animals; Calcium; Electroencephalography; gamma-Aminobutyric Acid; Glutamic Acid; Isoflurane; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence, Multiphoton; Parvalbumins; Pyramidal Cells; Synaptic Transmission; Unconsciousness; Vasoactive Intestinal Peptide

2021
Selective inhibition of gamma aminobutyric acid release from mouse hippocampal interneurone subtypes by the volatile anaesthetic isoflurane.
    British journal of anaesthesia, 2021, Volume: 127, Issue:4

    Topics: Anesthetics, Inhalation; Animals; Exocytosis; Female; gamma-Aminobutyric Acid; Gene Knockdown Techniques; Hippocampus; Isoflurane; Male; Mice; Mice, Transgenic; Neurons; Synaptic Transmission; Voltage-Gated Sodium Channels

2021