isoalantolactone has been researched along with sesquiterpenes in 59 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.39) | 18.7374 |
| 1990's | 4 (6.78) | 18.2507 |
| 2000's | 5 (8.47) | 29.6817 |
| 2010's | 38 (64.41) | 24.3611 |
| 2020's | 10 (16.95) | 2.80 |
| Authors | Studies |
|---|---|
| Alonso Blasi, N; Benezra, C; Fraginals, R; Lepoittevin, JP | 1 |
| Benezra, C; Geleick, H; Hausen, B; Klecak, G; Schulz, KH; Stampf, JL | 1 |
| Benezra, C; Gabriel-Robez, O; Grosshans, E; Schlewer, G; Stampf, JL | 1 |
| Bork, PM; Escher, C; Heinrich, M; Kuhnt, M; Schmitz, ML | 1 |
| Berl, V; Lepoittevin, JP | 1 |
| Menendez, IY; Wong, HR | 1 |
| Fiedler, MA; Mazor, RL; Menendez, IY; Ryan, MA; Wong, HR | 1 |
| Bever, CT; Burt, DR; Judge, SI; Li, QQ; Trisler, GD | 1 |
| Hake, PW; Sheehan, M; Wong, HR; Zingarelli, B | 1 |
| Inman, AO; Monteiro-Riviere, NA; Riviere, JE | 1 |
| Choi, SJ; Kang, HJ; Kim, HJ; Kim, JS; Lee, IA; Lim, JS; Lim, SS; Park, J; Park, JH; Seo, JY | 1 |
| Huo, Y; Li, W; Li, X; Shi, H; Wang, M | 1 |
| Adamson, G; Oslund, KL; Wu, R | 1 |
| Becnel, JJ; Cantrell, CL; Fronczek, FR; Pridgeon, JW | 1 |
| Adelibieke, Y; Adijiang, A; Bolati, D; Enomoto, A; Higashiyama, Y; Higuchi, Y; Muteliefu, G; Nishijima, F; Niwa, T; Shimizu, H | 1 |
| Adijiang, A; Bolati, D; Dateki, M; Enomoto, A; Muteliefu, G; Nishijima, F; Niwa, T; Shimizu, H | 1 |
| Bhasin, M; Cordeiro, J; Correa, RG; Czibere, A; Fisher, PB; Gu, X; Li, L; Libermann, TA; Sarkar, D; Simabuco, FM; Tamura, RE; Wang, Y; Zerbini, LF; Zhou, JR | 1 |
| Dai, X; Deng, X; Dong, J; Leng, B; Li, H; Luo, M; Niu, X; Qiu, J; Wang, J; Zhang, Q; Zhang, Y | 1 |
| Ding, C; Fang, X; Gao, H; Gao, R; Khan, M; Li, T; Ma, T; Rasul, A; Yi, F; Zhang, K; Zhong, L | 1 |
| Ali, M; Bo, YJ; Khan, M; Ma, T; Rasul, A; Yang, H; Yu, B | 1 |
| Ali, M; Di, J; Li, J; Li, X; Malhi, M; Millimouno, FM; Rasul, A; Tsuji, I | 1 |
| Hu, J; Li, C; Li, H; Li, L; Mei, X; Ren, F; Weng, Z; Wu, M; Zhang, H; Zhao, Y | 1 |
| Ali, M; Khan, M; Li, J; Li, X; Rasul, A | 1 |
| Guo, C; Niu, K; Teng, S; Zhang, S | 1 |
| Hu, HH; Jiang, HD; Kong, LM; Xu, SY; Yu, LS; Zeng, S; Zhou, H | 1 |
| Cai, H; Li, Y; Liu, Y; Meng, X; Yang, C | 1 |
| Di, W; Feng, L; Khan, M; Ma, T; Rasul, A; Sui, Y; Sun, M; Yang, L; Zhong, L; Zhu, Q | 1 |
| Li, X; Peng, Y; Wang, M; Xu, R; Zhou, G | 1 |
| Fan, Y; Gao, H; Hu, J; Li, L; Liu, H; Wang, H; Weng, Z | 1 |
| Fan, Y; Gao, H; Hu, J; Li, L; Wang, H; Weng, Z | 1 |
| Bai, R; Chen, L; Li, T; Liao, W; Liu, Y; Peng, S; Wu, C; Wu, M; Yang, H; Zeng, H; Zhao, X | 1 |
| Cui, L; Feng, L; Jia, X; Liu, D; Song, J; Wang, J; Zhang, Z | 1 |
| Huo, C; Kiyota, H; Li, L; Shi, Q; Shi, X; Wang, Y; Wu, Y; Yao, D; Zhang, M | 1 |
| Li, Z; Mao, J; Qi, X; Qin, B; Wu, D | 1 |
| Cai, H; Guan, YH; Yang, CH; Zhang, XD | 1 |
| Kim, J; Kim, JS; Lee, KW; Lim, SS; Seo, JY | 1 |
| Chen, J; Chen, Y; He, G; Li, L; Xie, Y; Zhang, X | 1 |
| Ahmad, I; Arha, D; Gayen, JR; Gupta, AP; Maurya, R; Rai, AK; Ramakrishna, E; Riyazuddin, M; Sharma, A; Tamrakar, AK | 1 |
| Hua, P; Jin, C; Li, B; Li, X; Song, G; Sun, M; Tong, T; Zhang, G; Zhang, X; Zhang, Y | 1 |
| Chen, L; Ge, G; Lan, G; Liu, Q; Mao, L; Ning, J; Shen, Y; Wang, S; Yang, L; Yang, N; Ye, J; Zhang, W; Zhou, B; Zhuo, Z | 1 |
| Li, Y; Li, ZH; Liu, ZX; Lü, H; Tian, ZQ; Wen, SW; Xu, YZ; Zhang, YF; Zhu, YG | 1 |
| Fang, M; Hua, P; Liu, T; Lu, Z; Wu, M; Zhang, G; Zhang, Y | 1 |
| Tian, L; Yang, B; Yuan, CB; Zhou, HY | 1 |
| Ding, YH; He, HQ; Hu, YD; Jiang, HC; Li, XZ; Qian, F; Song, YD; Sun, L; Wu, YX; Yu, KK; Yu, TH; Zhang, DP | 1 |
| Li, X; Peng, Y; Wang, M; Xu, R | 1 |
| Chen, H; Gao, X; Wang, K; Wang, M; Xu, M; Zhao, K | 1 |
| Cho, HR; Jung, YS; Kim, JH; Kim, KJ; Lee, HS; Lee, SO; Safe, S | 1 |
| Chen, W; Huang, H; Li, P; Liu, Y; Yang, Y; Ye, X; Zhang, F | 1 |
| Lan, YL; Li, XY; Lou, JC; Ma, B; Wang, D; Wang, X; Xing, JS; Yu, Z; Yuan, Z; Zhang, B; Zhang, H; Zhu, T | 1 |
| Guo, Y; Lu, N; Lv, Q; Qiu, J; Sun, X; Wang, J; Zhang, P; Zhou, Y | 1 |
| Chen, T; Chen, Y; He, R; Hou, W; Kuang, Z; Lu, J; Tang, L; Ye, C | 1 |
| Huang, L; Jia, Y; Song, X; Xie, L; Xiong, J; Yao, Y; Ying, S; Yuan, J; Zeng, Z; Zhang, C | 1 |
| Li, X; Liu, F; Shen, Y; Song, Y; Zhu, H | 1 |
| Hui, XG; Huo, L; Li, WH; Li, XB; Liang, J; Ma, T; Peng, W; Sun, DX; Sun, ZQ; Wu, ZC; Zhang, Y | 1 |
| Hu, F; Yang, P | 1 |
| Fu, S; Gao, X; He, D; He, Y; Li, J; Li, Z; Liu, D; Liu, Y; Wang, H; Ye, B | 1 |
| Lattoo, SK; Mudassir Jeelani, S; Prakash Gupta, A; Shahnawaz, M | 1 |
| Chen, J; Hou, L; Li, J; Liu, K; Maharajan, K; Mi, M; Xia, Q; Zhang, Y; Zhou, C | 1 |
| Cai, Q; Ni, Z; Sun, Y; Wang, M; Wang, S; Wang, X; Xu, L | 1 |
2 review(s) available for isoalantolactone and sesquiterpenes
| Article | Year |
|---|---|
Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Humans; Lactones; Neoplasm Proteins; Neoplasms; Sesquiterpenes; Sesquiterpenes, Eudesmane | 2013 |
Research progress on pharmacological effects of isoalantolactone.
Topics: Anti-Inflammatory Agents; Humans; Neoplasms; Sesquiterpenes | 2023 |
57 other study(ies) available for isoalantolactone and sesquiterpenes
| Article | Year |
|---|---|
A murine in vitro model of allergic contact dermatitis to sesquiterpene alpha-methylene-gamma-butyrolactones.
Topics: Animals; Cross Reactions; Dermatitis, Allergic Contact; Disease Models, Animal; In Vitro Techniques; Lactones; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Sesquiterpenes; Sesquiterpenes, Eudesmane; Species Specificity | 1992 |
The sensitizing capacity of helenin and of two of its main constituents, the sesquiterpene lactones alantolactone and isoalantolactone: a comparison of epicutaneous and intradermal sensitizing methods in different strains of guinea pig.
Topics: Administration, Topical; Animals; Dermatitis, Contact; Female; Guinea Pigs; Injections, Intradermal; Lactones; Sesquiterpenes; Sesquiterpenes, Eudesmane | 1982 |
Allergic contact dermatitis to methylenelactones. Use of lymphocyte transformation test.
Topics: Allergens; Animals; Cells, Cultured; Chemical Phenomena; Chemistry; Dermatitis, Atopic; Dermatitis, Contact; Guinea Pigs; Lactones; Lymphocyte Activation; Methods; Sesquiterpenes; Sesquiterpenes, Eudesmane | 1982 |
Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillaries; Chick Embryo; DNA; DNA-Binding Proteins; HeLa Cells; Host Cell Factor C1; Humans; Indians, North American; Interleukin-6; Lactones; Medicine, Traditional; Mexico; NF-kappa B; Octamer Transcription Factor-1; Plant Extracts; Plants, Medicinal; Sesquiterpenes; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transfection | 1997 |
Evidence for [2 + 2] photoreaction of alpha-methylene-gamma-butyrolactones with thymine: an explanation for chronic actinic dermatitis to sesquiterpene lactones?
Topics: Dermatitis, Allergic Contact; Humans; Magnetic Resonance Spectroscopy; Photochemistry; Photosensitivity Disorders; Sesquiterpenes; Thymine | 1999 |
Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells.
Topics: Animals; Anti-Inflammatory Agents; Aorta; Cell Compartmentation; Cell Nucleus; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; I-kappa B Proteins; Interferon-gamma; Lactones; Lipopolysaccharides; Muscle, Smooth, Vascular; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Rats; Sesquiterpenes | 1999 |
Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium.
Topics: Anti-Inflammatory Agents; Biological Transport; DNA-Binding Proteins; Epithelium; Gene Expression Regulation; Humans; I-kappa B Proteins; Interleukin-8; Lung; NF-kappa B; NF-KappaB Inhibitor alpha; Plants, Medicinal; Promoter Regions, Genetic; RNA, Messenger; Sesquiterpenes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Induction of RANTES chemokine expression in human astrocytic cells is dependent upon activation of NF-kappaB transcription factor.
Topics: Astrocytes; Chemokine CCL5; DNA-Binding Proteins; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; NF-kappa B; Pyrrolidines; RNA, Messenger; Sesquiterpenes; Thiocarbamates; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Protective effects of isohelenin, an inhibitor of nuclear factor kappaB, in endotoxic shock in rats.
Topics: Acetylcholine; Animals; Blotting, Western; Electrophoresis; Endotoxins; Hemodynamics; Lipopolysaccharides; Lung; Mice; Muscle Contraction; Muscle, Smooth, Vascular; NF-kappa B; Nitrates; Nitrites; Norepinephrine; Proteins; Rats; Sesquiterpenes; Shock, Septic | 2002 |
Inhibition of jet fuel aliphatic hydrocarbon induced toxicity in human epidermal keratinocytes.
Topics: Alkanes; Anti-Inflammatory Agents; Cell Survival; Cells, Cultured; Cytokines; Humans; Hydrocarbons; Imidazoles; Interleukin-10; Irritants; Keratinocytes; NF-kappa B; Protein Kinase Inhibitors; Pyridines; Recombinant Proteins; Sesquiterpenes; Substance P; Time Factors | 2008 |
Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzymes; Fruit; Hep G2 Cells; Humans; Inactivation, Metabolic; Inula; Liver Neoplasms; Mice; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Phytotherapy; Plant Extracts; Plant Roots; Sesquiterpenes | 2009 |
HPLC determination and NMR structural elucidation of sesquiterpene lactones in Inula helenium.
Topics: Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Inula; Isomerism; Lactones; Magnetic Resonance Spectroscopy; Molecular Structure; Reproducibility of Results; Sesquiterpenes; Sesquiterpenes, Eudesmane | 2010 |
Evaluation of MUC5AC expression and upregulation in airway epithelial cells of horses.
Topics: Airway Obstruction; Animals; Epithelial Cells; Horse Diseases; Horses; Microscopy, Electron, Scanning; Mucin 5AC; NF-kappa B; Respiratory Mucosa; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sesquiterpenes; Trachea; Transcription, Genetic; Tumor Necrosis Factor-alpha; Up-Regulation | 2010 |
Structure-activity relationship studies on derivatives of eudesmanolides from Inula helenium as toxicants against Aedes aegypti larvae and adults.
Topics: Aedes; Animals; Crystallography, X-Ray; Insecticides; Inula; Lactones; Larva; Models, Molecular; Sesquiterpenes; Sesquiterpenes, Eudesmane; Structure-Activity Relationship | 2010 |
Indoxyl sulfate downregulates renal expression of Klotho through production of ROS and activation of nuclear factor-ĸB.
Topics: Acetylcysteine; Animals; Antioxidants; Down-Regulation; Gene Expression Regulation; Glucuronidase; Humans; Indican; Klotho Proteins; NF-kappa B; Pyrrolidines; Rats; Rats, Inbred Dahl; Reactive Oxygen Species; Sesquiterpenes; Thiocarbamates | 2011 |
NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells.
Topics: Actins; Acute Kidney Injury; Animals; Benzothiazoles; beta-Galactosidase; Cell Line; Cell Proliferation; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Humans; Indican; Kidney Tubules, Proximal; Male; NF-kappa B; Promoter Regions, Genetic; Pyrrolidines; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Sesquiterpenes; Thiocarbamates; Toluene; Transforming Growth Factor beta1; Tumor Suppressor Protein p53 | 2011 |
Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Diclofenac; Drug Synergism; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukins; Intracellular Signaling Peptides and Proteins; JNK Mitogen-Activated Protein Kinases; Mice; Mice, SCID; NF-kappa B; Nuclear Proteins; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sesquiterpenes; Sulindac; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Isoalantolactone protects against Staphylococcus aureus pneumonia.
Topics: Animals; Bacterial Toxins; Cell Line; Gene Expression Regulation, Bacterial; Humans; Inula; Mice; Mice, Inbred C57BL; Plant Extracts; Pneumonia, Staphylococcal; Sesquiterpenes; Staphylococcus aureus | 2011 |
Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Humans; Immunoblotting; Lipid Peroxidation; Membrane Potential, Mitochondrial; Pancreatic Neoplasms; Reactive Oxygen Species; Sesquiterpenes | 2012 |
Isoalantolactone, a sesquiterpene lactone, induces apoptosis in SGC-7901 cells via mitochondrial and phosphatidylinositol 3-kinase/Akt signaling pathways.
Topics: Apoptosis; Caspases; Cell Cycle; Cell Line, Tumor; Cell Survival; Cyclin B1; Gene Expression Regulation, Neoplastic; Humans; Membrane Potential, Mitochondrial; Mitochondria; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction | 2013 |
Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Humans; Male; Membrane Potential, Mitochondrial; Prostatic Neoplasms; Reactive Oxygen Species; Sesquiterpenes | 2013 |
Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction.
Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin D; Flow Cytometry; G1 Phase Cell Cycle Checkpoints; Head and Neck Neoplasms; Humans; Mitochondria; rho GTP-Binding Proteins; Sesquiterpenes; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53 | 2013 |
Simultaneous determination of sesquiterpene lactones isoalantolactone and alantolactone isomers in rat plasma by liquid chromatography with tandem mass spectrometry: application to a pharmacokinetic study.
Topics: Animals; Chromatography, Liquid; Lactones; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Sesquiterpenes, Eudesmane; Stereoisomerism; Tandem Mass Spectrometry | 2014 |
Identification of CYP2C19 inhibitors from phytochemicals using the recombinant human enzyme model.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclooctanes; Cytochrome P-450 CYP2C19; Data Interpretation, Statistical; Enzyme Inhibitors; Fluvoxamine; Humans; Insecta; Lignans; Microsomes, Liver; Omeprazole; Plant Preparations; Polycyclic Compounds; Recombinant Proteins; Sesquiterpenes; Ticlopidine | 2014 |
Growth inhibition effects of isoalantolactone on K562/A02 cells: caspase-dependent apoptotic pathways, S phase arrest, and downregulation of Bcr/Abl.
Topics: Apoptosis; Caspases; Cell Proliferation; Cytochromes c; Down-Regulation; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; K562 Cells; Membrane Potential, Mitochondrial; Poly(ADP-ribose) Polymerases; Reactive Oxygen Species; S Phase; Sesquiterpenes | 2014 |
Isoalantolactone inhibits constitutive NF-κB activation and induces reactive oxygen species-mediated apoptosis in osteosarcoma U2OS cells through mitochondrial dysfunction.
Topics: Apoptosis; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Humans; Membrane Potential, Mitochondrial; Mitochondria; NF-kappa B; Osteosarcoma; Reactive Oxygen Species; Sesquiterpenes | 2014 |
Pharmacokinetics, tissue distribution and excretion of isoalantolactone and alantolactone in rats after oral administration of Radix Inulae extract.
Topics: Administration, Oral; Animals; Chromatography, Liquid; Gastropoda; Lactones; Male; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Sesquiterpenes, Eudesmane; Tandem Mass Spectrometry; Tissue Extracts | 2015 |
Isoalantolactone Enhances the Radiosensitivity of UMSCC-10A Cells via Specific Inhibition of Erk1/2 Phosphorylation.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; G2 Phase; Head and Neck Neoplasms; Hep G2 Cells; Humans; MAP Kinase Signaling System; Phosphorylation; Radiation Tolerance; Radiation-Sensitizing Agents; Rats; Sesquiterpenes; Signal Transduction | 2015 |
Isoalantolactone induces autophagic cell death in SKOV₃ human ovarian carcinoma cells via upregulation of PEA-15.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis Regulatory Proteins; Autophagy; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Female; Gene Knockdown Techniques; Humans; Intracellular Signaling Peptides and Proteins; Mice, Inbred C57BL; Ovarian Neoplasms; Phosphoproteins; RNA, Small Interfering; Sesquiterpenes; Transfection; Up-Regulation; Xenograft Model Antitumor Assays | 2016 |
Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms.
Topics: Adenosine Triphosphatases; Angelica; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; Cell Membrane; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Inula; MCF-7 Cells; Membrane Fluidity; Models, Molecular; Oils, Volatile; RNA, Messenger; Sesquiterpenes | 2016 |
Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Cell Movement; Down-Regulation; Female; Humans; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Sesquiterpenes; Signal Transduction; Transcription Factor RelA | 2016 |
Study on the metabolites of isoalantolactone in vivo and in vitro by ultra performance liquid chromatography combined with Triple TOF mass spectrometry.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Chromatography, Liquid; Rats; Sesquiterpenes; Tandem Mass Spectrometry | 2017 |
Isoalantolactone induces apoptosis in human breast cancer cells via ROS-mediated mitochondrial pathway and downregulation of SIRT1.
Topics: Apoptosis; Breast Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Female; Humans; MCF-7 Cells; Mitochondria; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Sirtuin 1 | 2016 |
[Isoalantolactone Inhibits Proliferation of K562/A02 Cells through Caspase-Dependent Apoptotic Pathway].
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Proliferation; Humans; K562 Cells; Sesquiterpenes | 2017 |
Alantolactone and Isoalantolactone Prevent Amyloid β
Topics: Amyloid beta-Peptides; Animals; Avoidance Learning; Cognition Disorders; Cognitive Dysfunction; Lactones; Male; Maze Learning; Memory Disorders; Mice; Neurons; Neuroprotective Agents; Peptide Fragments; Scopolamine; Sesquiterpenes; Sesquiterpenes, Eudesmane | 2017 |
Isoalantolactone inhibits LPS-induced inflammation via NF-κB inactivation in peritoneal macrophages and improves survival in sepsis.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Inflammation; Interleukin-6; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide; RAW 264.7 Cells; Sepsis; Sesquiterpenes; Signal Transduction; Survival Rate; Tumor Necrosis Factor-alpha | 2017 |
Isoalantolactone derivative promotes glucose utilization in skeletal muscle cells and increases energy expenditure in db/db mice via activating AMPK-dependent signaling.
Topics: AMP-Activated Protein Kinases; Animals; Cell Membrane; Diabetes Mellitus, Experimental; Energy Metabolism; Gene Expression Regulation; Glucose; Glucose Transporter Type 4; Lipid Metabolism; Male; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Muscle, Skeletal; Phosphatidylinositol 3-Kinases; Protein Transport; Rats; Sesquiterpenes; Signal Transduction; Time Factors | 2018 |
Isoalantolactone induces intrinsic apoptosis through p53 signaling pathway in human lung squamous carcinoma cells.
Topics: Apoptosis; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Caspases; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2017 |
Metabolism and pharmacokinetics of alantolactone and isoalantolactone in rats: Thiol conjugation as a potential metabolic pathway.
Topics: Animals; Chromatography, Liquid; Cysteine; Glutathione; Humans; Lactones; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Sesquiterpenes, Eudesmane; Sulfhydryl Compounds; Tandem Mass Spectrometry | 2018 |
Isoalantolactone Inhibits Esophageal Squamous Cell Carcinoma Growth Through Downregulation of MicroRNA-21 and Derepression of PDCD4.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Squamous Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; RNA-Binding Proteins; Sesquiterpenes; Signal Transduction; Time Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
Isoalantolactone induces apoptosis through reactive oxygen species-dependent upregulation of death receptor 5 in human esophageal cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Esophageal Neoplasms; Humans; Mice, Inbred BALB C; Mice, Nude; Oxidative Stress; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; Sesquiterpenes; Signal Transduction; Up-Regulation; Xenograft Model Antitumor Assays | 2018 |
Isoalantolactone protects LPS-induced acute lung injury through Nrf2 activation.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Disease Models, Animal; Interleukin-1beta; Lipopolysaccharides; Lung; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Phosphatidylinositol 3-Kinases; Protective Agents; Sesquiterpenes; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Cytokines; HEK293 Cells; Humans; Inflammation; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Lung; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-kappa B p50 Subunit; Sesquiterpenes; Signal Transduction; TNF Receptor-Associated Factor 6; Ubiquitination | 2019 |
Intestinal Absorption of Isoalantolactone and Alantolactone, Two Sesquiterpene Lactones from Radix Inulae, Using Caco-2 Cells.
Topics: Administration, Oral; Biological Availability; Caco-2 Cells; Dose-Response Relationship, Drug; Humans; Intestinal Absorption; Inula; Lactones; Permeability; Plant Roots; Sesquiterpenes; Sesquiterpenes, Eudesmane | 2019 |
Anti-inflammatory effects of isoalantolactone on LPS-stimulated BV2 microglia cells through activating GSK-3β-Nrf2 signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Dinoprostone; Glycogen Synthase Kinase 3 beta; Interleukin-1beta; Inula; Lipopolysaccharides; Mice; Microglia; Neurogenic Inflammation; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Phosphorylation; Sesquiterpenes; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
Dual targeting of Nur77 and AMPKα by isoalantolactone inhibits adipogenesis in vitro and decreases body fat mass in vivo.
Topics: 3T3-L1 Cells; Adipogenesis; AMP-Activated Protein Kinases; Animals; Anti-Obesity Agents; Cells, Cultured; Diet, High-Fat; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Obese; Nuclear Receptor Subfamily 4, Group A, Member 1; Polyphenols; Sesquiterpenes | 2019 |
Isoalantolactone induces apoptosis through ROS-mediated ER stress and inhibition of STAT3 in prostate cancer cells.
Topics: Animals; Cell Line, Tumor; Endoplasmic Reticulum Stress; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Random Allocation; Reactive Oxygen Species; Sesquiterpenes; STAT3 Transcription Factor | 2018 |
Isoalantolactone inhibits IKKβ kinase activity to interrupt the NF-κB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma.
Topics: Actin Depolymerizing Factors; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Glioblastoma; Heterografts; Humans; I-kappa B Kinase; Male; Mice; Mitochondria; Molecular Structure; NF-kappa B; Protein Transport; Sesquiterpenes; Signal Transduction | 2019 |
Isoalantolactone restores the sensitivity of gram-negative Enterobacteriaceae carrying MCR-1 to carbapenems.
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Carbapenems; Enterobacteriaceae; Escherichia coli; Escherichia coli Infections; Female; Klebsiella Infections; Klebsiella pneumoniae; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Polymyxin B; Sesquiterpenes | 2020 |
Isoalantolactone inhibits RANKL-induced osteoclast formation via multiple signaling pathways.
Topics: Actins; Animals; Bone Resorption; Cathepsin K; Cells, Cultured; Female; Macrophages; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Ovariectomy; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-fos; RANK Ligand; Sesquiterpenes; Signal Transduction | 2020 |
Isoalantolactone inhibits pancreatic cancer proliferation by regulation of PI3K and Wnt signal pathway.
Topics: Adenocarcinoma; Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Male; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Sesquiterpenes; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2021 |
Isoalantolactone alleviates ovalbumin‑induced asthmatic inflammation by reducing alternatively activated macrophage and STAT6/PPAR‑γ/KLF4 signals.
Topics: Animals; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Asthma; Chemokine CCL17; Cytokines; Female; Humans; Immunoglobulin E; Inflammation; Interleukin-4; Kruppel-Like Factor 4; Lipopolysaccharides; Lung; Macrophages; Mice; Mice, Inbred BALB C; Ovalbumin; PPAR gamma; Sesquiterpenes; STAT6 Transcription Factor | 2021 |
Antiproliferative effects of isoalantolactone in human liver cancer cells are mediated through caspase-dependent apoptosis, ROS generation, suppression of cell migration and invasion and targeting Ras/Raf/MEK signalling pathway.
Topics: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; Liver Neoplasms; Mitogen-Activated Protein Kinase Kinases; Reactive Oxygen Species; Sesquiterpenes | 2022 |
Isoalantolactone exerts anticancer effects on human HEC-1-B endometrial cancer cells via induction of ROS mediated apoptosis and inhibition of MEK/ERK signalling pathway.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Endometrial Neoplasms; Female; Humans; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Reactive Oxygen Species; Sesquiterpenes | 2022 |
Isoalantolactone (IAL) Regulates Neuro-Inflammation and Neuronal Apoptosis to Curb Pathology of Parkinson's Disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Animals; Apoptosis; Inflammation; Inflammation Mediators; Iodides; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Neurodegenerative Diseases; NF-E2-Related Factor 2; NF-kappa B; Parkinson Disease; Proto-Oncogene Proteins c-akt; Pyrrolidines; Sesquiterpenes | 2022 |
Phytochemical Diversity in Relation to Cytogenetic Variability in Inula racemosa Hook.f., an Endangered Medicinal Plant of Himalayas.
Topics: Chromatography, Liquid; Cytogenetic Analysis; Humans; Inula; Phytochemicals; Plants, Medicinal; Sesquiterpenes; Tandem Mass Spectrometry; Tetraploidy | 2022 |
Isoalantolactone protects against ethanol-induced gastric ulcer via alleviating inflammation through regulation of PI3K-Akt signaling pathway and Th17 cell differentiation.
Topics: Animals; Anti-Inflammatory Agents; Ethanol; Humans; Inflammation; Molecular Docking Simulation; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction; Stomach Ulcer; Zebrafish | 2023 |