Compounds > irofulven
Page last updated: 2024-09-04

irofulven and topotecan

irofulven has been researched along with topotecan in 3 studies

Compound Research Comparison

Studies
(irofulven)		Trials
(irofulven)		Recent Studies (post-2010)
(irofulven)		Studies
(topotecan)		Trials
(topotecan)		Recent Studies (post-2010) (topotecan)
992272,392626792

Protein Interaction Comparison

ProteinTaxonomyirofulven (IC50)topotecan (IC50)
Cytochrome P450 3A4Homo sapiens (human)1.5211
DNA topoisomerase 1Homo sapiens (human)0.8525
DNA topoisomerase 2-alphaHomo sapiens (human)0.605
DNA topoisomerase 2-betaHomo sapiens (human)0.605
Hypoxia-inducible factor 1-alphaHomo sapiens (human)0.06
Multidrug and toxin extrusion protein 2Homo sapiens (human)8.6
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.3
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.17

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Estes, L; Kelner, MJ; MacDonald, JR; McMorris, TC; Samson, KM; Trani, NA1
Eckhardt, SG; Hammond, LA; Hilsenbeck, SG; MacDonald, JR; Mangold, G; Marty, J; Rowinsky, EK; Von Hoff, DD; Weitman, S1

Other Studies

3 other study(ies) available for irofulven and topotecan

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with topotecan.
    Leukemia, 2000, Volume: 14, Issue:1

    Topics: Animals; Antineoplastic Agents; Drug Synergism; Female; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Mice; Mice, Inbred BALB C; Mice, Nude; Sesquiterpenes; Topotecan

2000
Enhanced antitumour activity of 6-hydroxymethylacylfulvene in combination with topotecan or paclitaxel in the MV522 lung carcinoma xenograft model.
    European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:18

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Sesquiterpenes; Topotecan; Transplantation, Heterologous

2000