Page last updated: 2024-09-04

irofulven and gemcitabine

irofulven has been researched along with gemcitabine in 3 studies

Compound Research Comparison

Studies (irofulven)	Trials (irofulven)	Recent Studies (post-2010) (irofulven)	Studies (gemcitabine)	Trials (gemcitabine)	Recent Studies (post-2010) (gemcitabine)
99	22	7	12,523	3,208	6,923

Protein Interaction Comparison

Protein	Taxonomy	irofulven (IC50)	gemcitabine (IC50)
Chain A, DEOXYNUCLEOSIDE KINASE	Drosophila melanogaster (fruit fly)		0.76
Equilibrative nucleoside transporter 1	Homo sapiens (human)		0.19

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Lombardo, F; Obach, RS; Waters, NJ	1
Kulke, MH	1
Estes, LA; Kelner, MJ; McMorris, TC; Rojas, RJ; Suthipinijtham, P	1

Reviews

1 review(s) available for irofulven and gemcitabine

Article	Year
Advanced pancreatic cancer: is there a role for combination therapy? Expert review of anticancer therapy, 2003, Volume: 3, Issue:5 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cysteine Endopeptidases; Deoxycytidine; Fluorouracil; Gemcitabine; Genes, ras; Glutamates; Guanine; Humans; Multienzyme Complexes; Pancreatic Neoplasms; Pemetrexed; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein-Tyrosine Kinases; Sesquiterpenes	2003

Article

Year

Advanced pancreatic cancer: is there a role for combination therapy?

Expert review of anticancer therapy, 2003, Volume: 3, Issue:5

Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cysteine Endopeptidases; Deoxycytidine; Fluorouracil; Gemcitabine; Genes, ras; Glutamates; Guanine; Humans; Multienzyme Complexes; Pancreatic Neoplasms; Pemetrexed; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein-Tyrosine Kinases; Sesquiterpenes

2003

Other Studies

2 other study(ies) available for irofulven and gemcitabine

Article	Year
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil. Investigational new drugs, 2008, Volume: 26, Issue:5 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Random Allocation; Sesquiterpenes; Xenograft Model Antitumor Assays	2008

Article

Year

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.

Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008

Synergy of Irofulven in combination with various anti-metabolites, enzyme inhibitors, and miscellaneous agents in MV522 lung carcinoma cells: marked interaction with gemcitabine and 5-fluorouracil.

Investigational new drugs, 2008, Volume: 26, Issue:5

Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Random Allocation; Sesquiterpenes; Xenograft Model Antitumor Assays

2008