Compounds > irofulven
Page last updated: 2024-09-04

irofulven and acylfulvene

irofulven has been researched along with acylfulvene in 5 studies

Compound Research Comparison

Studies
(irofulven)		Trials
(irofulven)		Recent Studies (post-2010)
(irofulven)		Studies
(acylfulvene)		Trials
(acylfulvene)		Recent Studies (post-2010) (acylfulvene)
992272208

Protein Interaction Comparison

ProteinTaxonomyirofulven (IC50)acylfulvene (IC50)
Prostaglandin reductase 1Rattus norvegicus (Norway rat)0.095

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Estes, LA; Kelner, MJ; McMorris, TC; Taetle, R; Wang, W; Yu, J1
Kelner, MJ; McMorris, TC; Ngo, HT; Wang, H; Yu, J1
Gong, J; Kensler, TW; Neels, JF; Peterson, LA; Sturla, SJ; Yu, X1
Movassaghi, M; Piersanti, G; Piizzi, G; Siegel, DS1
Glatt, H; Meinl, W; Pietsch, KE; Sturla, SJ1

Other Studies

5 other study(ies) available for irofulven and acylfulvene

ArticleYear
(Hydroxymethyl)acylfulvene: an illudin derivative with superior antitumor properties.
    Journal of natural products, 1996, Volume: 59, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Basidiomycota; Chromatography, Thin Layer; Crystallography, X-Ray; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Polycyclic Sesquiterpenes; Sesquiterpenes

1996
Preparation and biological activity of amino acid and peptide conjugates of antitumor hydroxymethylacylfulvene.
    Journal of medicinal chemistry, 2000, Sep-21, Volume: 43, Issue:19

    Topics: Amino Acids; Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; Inhibitory Concentration 50; Peptides; Rats; Sesquiterpenes; Tumor Cells, Cultured

2000
Investigating the role of stereochemistry in the activity of anticancer acylfulvenes: synthesis, reductase-mediated bioactivation, and cellular toxicity.
    Journal of medicinal chemistry, 2006, Apr-20, Volume: 49, Issue:8

    Topics: Alcohol Oxidoreductases; Animals; Antineoplastic Agents; Biotransformation; Cell Line; Cell Survival; Enzyme Activation; Humans; Molecular Conformation; Rats; Recombinant Proteins; Sesquiterpenes; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Transfection

2006
Enantioselective total synthesis of (-)-acylfulvene and (-)-irofulven.
    The Journal of organic chemistry, 2009, Dec-18, Volume: 74, Issue:24

    Topics: Allyl Compounds; Antineoplastic Agents; Catalysis; Copper; Hydrogen; Magnetic Resonance Spectroscopy; Models, Chemical; Sesquiterpenes; Spiro Compounds; Stereoisomerism

2009
Sulfotransferase-independent genotoxicity of illudin S and its acylfulvene derivatives in bacterial and mammalian cells.
    Archives of toxicology, 2014, Volume: 88, Issue:1

    Topics: Animals; Arylsulfotransferase; Cell Line; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Humans; Mutagenicity Tests; Mutagens; Mutation; Polycyclic Sesquiterpenes; Salmonella typhimurium; Sesquiterpenes; Sister Chromatid Exchange; Spiro Compounds; Sulfotransferases

2014