Page last updated: 2024-08-24

irinotecan and hypericum

irinotecan has been researched along with hypericum in 9 studies

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (77.78)	29.6817
2010's	1 (11.11)	24.3611
2020's	1 (11.11)	2.80

Authors

Authors	Studies
Mansky, PJ; Straus, SE	1
de Bruijn, P; Loos, WJ; Mathijssen, RH; Sparreboom, A; Verweij, J	1
Burnakis, TG	1
Chan, E; Chan, SY; Chen, X; Duan, W; Ho, PC; Hu, Z; Huang, M; Li, X; Xu, C; Yang, H; Yang, X; Zhou, S; Zhu, YZ	1
Boelsterli, UA; Chan, E; Chan, SY; Duan, W; Ee, PL; Hu, ZP; Huang, M; Koh, HL; Sheu, FS; Wang, JC; Xu, AL; Yang, XX; Zhang, Q; Zhou, SF; Zhu, YZ	1
Birdsall, TC	1
Cao, J; Chan, E; Chen, X; Duan, W; Hu, ZP; Huang, M; Wen, JY; Yang, XX; Yu, XQ; Zhou, SF	1
Coward, L; Darby, A; Gorman, GS; Rasberry, B	1
Chen, J; Dou, T; Ge, G; Liu, K; Meng, Q; Sun, H; Wang, C; Wang, D; Wu, J; Zhao, S; Zhao, T	1

Trials

1 trial(s) available for irinotecan and hypericum

Article	Year
Effects of St. John's wort on irinotecan metabolism. Journal of the National Cancer Institute, 2002, Aug-21, Volume: 94, Issue:16 Topics: Antidepressive Agents; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Confidence Intervals; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hypericum; Irinotecan; Mixed Function Oxygenases; Topoisomerase I Inhibitors	2002

Article

Year

Effects of St. John's wort on irinotecan metabolism.

Journal of the National Cancer Institute, 2002, Aug-21, Volume: 94, Issue:16

Topics: Antidepressive Agents; Antineoplastic Agents, Phytogenic; Area Under Curve; Camptothecin; Confidence Intervals; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Hypericum; Irinotecan; Mixed Function Oxygenases; Topoisomerase I Inhibitors

2002

Other Studies

8 other study(ies) available for irinotecan and hypericum

Article	Year
St. John's Wort: more implications for cancer patients. Journal of the National Cancer Institute, 2002, Aug-21, Volume: 94, Issue:16 Topics: Antidepressive Agents; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Enzyme Induction; Enzyme Inhibitors; Humans; Hypericum; Irinotecan; Mixed Function Oxygenases; Neoplasms	2002
Comment: Usefulness of herbal and dietary supplement references. The Annals of pharmacotherapy, 2003, Volume: 37, Issue:9 Topics: Benzamides; Camptothecin; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Dietary Supplements; Drug Interactions; Humans; Hypericum; Imatinib Mesylate; Irinotecan; Phytotherapy; Piperazines; Plant Preparations; Pyrimidines; Reference Books	2003
St. John's Wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats. Pharmaceutical research, 2005, Volume: 22, Issue:6 Topics: Animals; Antineoplastic Agents, Phytogenic; Area Under Curve; Blood Cell Count; Body Weight; Camptothecin; Chromatography, High Pressure Liquid; Diarrhea; Drug Interactions; Half-Life; Hypericum; Intestinal Diseases; Intestinal Mucosa; Irinotecan; Male; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results	2005
St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis. Toxicology and applied pharmacology, 2006, Oct-15, Volume: 216, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cytokines; Diarrhea; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Hypericum; Intestinal Mucosa; Irinotecan; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley	2006
St. John's wort and irinotecan-induced diarrhea. Toxicology and applied pharmacology, 2007, Apr-01, Volume: 220, Issue:1 Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Diarrhea; Drug Interactions; Humans; Hypericum; Irinotecan; Phytotherapy; Plant Extracts	2007
A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort. Current drug metabolism, 2007, Volume: 8, Issue:2 Topics: Animals; Anthracenes; Antineoplastic Agents, Phytogenic; Bridged Bicyclo Compounds; Camptothecin; Cell Line, Tumor; Cell Proliferation; Glucuronides; Hypericum; Irinotecan; Male; Microsomes, Liver; Perylene; Phloroglucinol; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Terpenes	2007
Effects of herbal supplements on the bioactivation of chemotherapeutic agents. The Journal of pharmacy and pharmacology, 2013, Volume: 65, Issue:7 Topics: Antineoplastic Agents, Hormonal; Antineoplastic Agents, Phytogenic; Camptothecin; Carboxylesterase; Chromatography, High Pressure Liquid; Cimicifuga; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Humans; Hypericum; Inhibitory Concentration 50; Irinotecan; Microsomes, Liver; Plant Extracts; Regression Analysis; Tamoxifen; Tandem Mass Spectrometry; Zingiber officinale	2013
Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications for Herb-drug Combination. Current drug metabolism, 2022, Volume: 23, Issue:1 Topics: Anthracenes; Drug Combinations; Herb-Drug Interactions; Humans; Hypericum; Irinotecan; Molecular Docking Simulation; Perylene	2022