irinotecan has been researched along with 10-hydroxycamptothecin in 14 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Boehm, JC; Caranfa, MJ; Faucette, LF; Gallagher, G; Hecht, SM; Holden, KG; Jakas, DR; Johnson, RK; Kingsbury, WD; McCabe, FL | 1 |
| Alloatti, D; Badaloni, E; Cabri, W; Castorina, M; Giannini, G; Pisano, C; Vesci, L | 1 |
| Chen, W; Fu, K; Hu, J; Huang, W; Jiang, Z; Li, M; Shi, Y; Ye, W; Zhou, C; Zhou, W | 1 |
| Burke, TG; Mi, Z | 1 |
| Aimi, N; Chiba, K; Hosokawa, M; Satoh, T; Takayama, H; Watanabe, A | 1 |
| Azrak, RG; Cao, S; Durrani, FA; Frank, C; Li, ZR; Rustum, YM; Yin, MB | 1 |
| Danks, MK; Hyatt, JL; Lee, RE; Morton, CL; Potter, PM; Yoon, KJ | 1 |
| Ashkenazi, S; Huppert, D; Leiderman, P; Solntsev, KM; Sullivan, EN; Tolbert, LM | 1 |
| Fu, ZD; Li, DZ; Liu, HY; Pan, XD; Wang, CY; Wu, S | 1 |
| Leu, YL; Prijovich, ZM; Roffler, SR | 1 |
| Ewis, HE; Liu, P; Lu, CD; Tai, PC; Weber, IT | 1 |
| Bordovská, S; Meloun, M; Vrána, A | 1 |
| Cyrankiewicz, M; Kruszewski, S; Ziomkowska, B | 1 |
| Deng, T; Jiang, ZX; Mao, X; Xiao, Y; Yang, Z; Zheng, X | 1 |
14 other study(ies) available for irinotecan and 10-hydroxycamptothecin
| Article | Year |
|---|---|
Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cattle; Cell Line; Colonic Neoplasms; DNA, Superhelical; Drug Evaluation, Preclinical; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Leukemia L1210; Lung Neoplasms; Melanoma, Experimental; Mice; Molecular Structure; Plasmids; Structure-Activity Relationship; Thymus Gland; Topoisomerase I Inhibitors; Transplantation, Heterologous | 1991 |
Camptothecins in tumor homing via an RGD sequence mimetic.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Integrins; Male; Oligopeptides; Ovarian Neoplasms; Prostatic Neoplasms; Rats | 2012 |
Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation.
Topics: Animals; Antineoplastic Agents; Camptothecin; Cell Line; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Mice; Mice, Inbred ICR; Molecular Structure; Oligosaccharides; Solubility; Structure-Activity Relationship; Topoisomerase I Inhibitors | 2020 |
The structural basis of camptothecin interactions with human serum albumin: impact on drug stability.
Topics: Camptothecin; Carboxylic Acids; Chromatography, High Pressure Liquid; Half-Life; Irinotecan; Kinetics; Lactones; Molecular Structure; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Topotecan | 1994 |
Synthesis of a new class of camptothecin derivatives, the long-chain fatty acid esters of 10-hydroxycamptothecin, as a potent prodrug candidate, and their in vitro metabolic conversion by carboxylesterases.
Topics: Animals; Camptothecin; Carboxylic Ester Hydrolases; Esters; Fatty Acids; Humans; In Vitro Techniques; Irinotecan; Prodrugs; Rats; Swine | 1998 |
Enhanced 7-ethyl-10-hydroxycamptothecin (SN-38) lethality by methylselenocysteine is associated with Chk2 phosphorylation at threonine-68 and down-regulation of Cdc6 expression.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Carbon-Sulfur Lyases; Caspase 3; Caspases; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Survival; Checkpoint Kinase 1; Checkpoint Kinase 2; Cysteine; DNA Fragmentation; Drug Interactions; Enzyme Activation; Gene Expression; Humans; Irinotecan; Minichromosome Maintenance Complex Component 2; Nuclear Proteins; Organoselenium Compounds; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Kinases; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae Proteins; Selenocysteine | 2004 |
Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application.
Topics: Animals; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Intestinal Mucosa; Irinotecan; Kinetics; Liver; Models, Chemical; Nitrophenols; Protein Biosynthesis; Rabbits; Recombinant Proteins; Transfection | 2004 |
Excited-state proton transfer reactions of 10-hydroxycamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Hydrogen-Ion Concentration; Irinotecan; Kinetics; Protons; Spectrometry, Fluorescence; Structure-Activity Relationship; Titrimetry | 2004 |
Synthesis and antitumor activity of A-ring modified hexacyclic analogues of camptothecin.
Topics: Animals; Antineoplastic Agents; Camptothecin; Carcinoma, Hepatocellular; Cell Line, Tumor; Female; Humans; Irinotecan; Liver Neoplasms; Mice; Neoplasm Transplantation; Polycyclic Compounds | 2005 |
Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; DNA Fragmentation; Dose-Response Relationship, Drug; Glucuronidase; Glucuronides; Humans; Hybridomas; Hydrogen-Ion Concentration; Hydrolysis; Immunoconjugates; Inhibitory Concentration 50; Irinotecan; Lactones; Molecular Structure; Prodrugs; Serum Albumin; Thymidine; Time Factors; Topotecan; Tritium | 2007 |
Crystal structure of the Geobacillus stearothermophilus carboxylesterase Est55 and its activation of prodrug CPT-11.
Topics: Antineoplastic Agents, Phytogenic; Bacillaceae; Binding Sites; Camptothecin; Carboxylesterase; Crystallization; Crystallography; Cysteine; Iodine; Irinotecan; Models, Molecular; Prodrugs; Protein Conformation | 2007 |
The thermodynamic dissociation constants of the anticancer drugs camptothecine, 7-ethyl-10-hydroxycamptothecine, 10-hydroxycamptothecine and 7-ethylcamptothecine by the least-squares nonlinear regression of multiwavelength spectrophotometric pH-titration
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Hydrogen-Ion Concentration; Irinotecan; Least-Squares Analysis; Spectrophotometry, Ultraviolet; Thermodynamics; Titrimetry | 2007 |
Hydroxycamptothecin deactivation rates and binding to model membranes and HSA determined by fluorescence spectra analysis.
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; Humans; Irinotecan; Kinetics; Lipid Bilayers; Membranes, Artificial; Models, Biological; Protein Binding; Serum Albumin; Spectrometry, Fluorescence | 2007 |
Monodisperse oligoethylene glycols modified Camptothecin, 10-Hydroxycamptothecin and SN38 prodrugs.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Drug Liberation; Ethylene Glycols; Humans; Irinotecan; Prodrugs | 2019 |