iridoids and uvaol

Phytochemical investigation of the methanolic extract of Plumeria acutifolia (Apocynaceae) leaves has led to the isolation and identification by spectroscopic means of a new monoterpene alkaloid, (R)-4'-((S)-1-hydroxyethyl)-5,6-dihydro-5' H-spiro[cyclopenta[C]pyridine-7,2'-furan)-5'-one, for which the name plumerianine was adopted, the iridoid 15-demethylplumeride, and three known triterpenes, i. e., lupeol, uvaol and ursolic acid.

Topics: Alkaloids; Apocynaceae; Iridoids; Molecular Structure; Monoterpenes; Pentacyclic Triterpenes; Plant Leaves; Triterpenes; Ursolic Acid

To investigate the chemical constituents of Pyrola calliatha.. The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data.. Ten compounds were isolated and identified as chimaphilin (1), uvaol(2), ursolic acid (3), 2beta,3beta,23-trihydroxy-12-ene-28-ursolic acid (4), daucosterol (5), 2alpha,3beta,23,24-tetrahydroxy-12-ene-28-ursolic acid (6), emodin (7), gallic acid (8), monotropein (9), adenosine (10).. Compounds 2,4,6,7,10 were obtained from this genus for the first time, compounds 5, 9 were obtained from this species for the first time. Antifungal activity of compounds 1-4, 6-9 were evaluated. Compound 1 showed the strong activity.

Topics: Antifungal Agents; Cryptococcus neoformans; Iridoids; Naphthoquinones; Plants, Medicinal; Pyrola; Triterpenes