iridoids and methylamine

iridoids has been researched along with methylamine* in 2 studies

Other Studies

2 other study(ies) available for iridoids and methylamine

Article	Year
Chinese journal of natural medicines, 2018, Volume: 16, Issue:4 Diabetic nephropathy is one of the various complications of diabetes mellitus, affecting patients for lifetime. Earlier studies have revealed that genipin can not only improve diabetes, but also induce cytotoxicity. Therefore, it is not clear which effect of genipin on kidneys occurs, when it is used in the treatment of diabetes. In the present study, we performed nuclear magnetic resonance (NMR)-based metabolomics analysis of urine and kidney tissue samples obtained from diabetic rats to explore the change of endogenous metabolites associated with diabetes and concomitant kidney disease. Nine significant differential metabolites that were closely related to renal function were screened. They were mainly related to three metabolic pathways: synthesis and degradation of ketone bodies, glycine, serine and threonine metabolism, and butanoate metabolism, which are involved in methylamine metabolism, energy metabolism and amino acid metabolism. In addition, after the intervention of genipin, the metabolic levels of all the metabolites tended to be normal, indicating a protective effect of genipin on kidneys. Our results may be helpful for understanding the antidiabetic effect of genipin. Topics: Amino Acids; Animals; Diabetes Mellitus, Experimental; Energy Metabolism; Hypoglycemic Agents; Iridoids; Kidney; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Methylamines; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Sprague-Dawley	2018
Isolation and characterization of water-soluble intermediates of blue pigments transformed from geniposide of Gardenia jasminoides. Journal of agricultural and food chemistry, 2002, Oct-23, Volume: 50, Issue:22 Gardenia blue dye was obtained through the reaction of methylamine with genipin, the aglycone of geniposide isolated from the fruits of Gardenia jasminoides. The resulting blue pigments were passed through Bio-Gel P-2 resin yielding five fractions, GM1-GM5. Four fractions (GM1-GM4) were all blue pigments, and the first eluted higher molecular weight fraction GM1 had a higher tinctorial strength than the later eluted lower molecular weight fractions, GM2-GM4. The last eluted GM5 fraction with lambda(max) of 292 nm was colorless and was confirmed as the true intermediate of the blue pigments on the basis of UV-vis spectrophotometric evidence. The GM5 fraction was composed of two epimeric isomers, and their structures were characterized by (1)H NMR, (1)H-(1)H COSY, (13)C NMR, and HMQC and HMBC spectral measurements. Topics: Gardenia; Iridoids; Isomerism; Methylamines; Molecular Weight; Pigments, Biological; Pyrans; Solubility	2002

Article

Year

Chinese journal of natural medicines, 2018, Volume: 16, Issue:4

Diabetic nephropathy is one of the various complications of diabetes mellitus, affecting patients for lifetime. Earlier studies have revealed that genipin can not only improve diabetes, but also induce cytotoxicity. Therefore, it is not clear which effect of genipin on kidneys occurs, when it is used in the treatment of diabetes. In the present study, we performed nuclear magnetic resonance (NMR)-based metabolomics analysis of urine and kidney tissue samples obtained from diabetic rats to explore the change of endogenous metabolites associated with diabetes and concomitant kidney disease. Nine significant differential metabolites that were closely related to renal function were screened. They were mainly related to three metabolic pathways: synthesis and degradation of ketone bodies, glycine, serine and threonine metabolism, and butanoate metabolism, which are involved in methylamine metabolism, energy metabolism and amino acid metabolism. In addition, after the intervention of genipin, the metabolic levels of all the metabolites tended to be normal, indicating a protective effect of genipin on kidneys. Our results may be helpful for understanding the antidiabetic effect of genipin.

Topics: Amino Acids; Animals; Diabetes Mellitus, Experimental; Energy Metabolism; Hypoglycemic Agents; Iridoids; Kidney; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Methylamines; Proton Magnetic Resonance Spectroscopy; Rats; Rats, Sprague-Dawley

2018

Isolation and characterization of water-soluble intermediates of blue pigments transformed from geniposide of Gardenia jasminoides.

Journal of agricultural and food chemistry, 2002, Oct-23, Volume: 50, Issue:22

Gardenia blue dye was obtained through the reaction of methylamine with genipin, the aglycone of geniposide isolated from the fruits of Gardenia jasminoides. The resulting blue pigments were passed through Bio-Gel P-2 resin yielding five fractions, GM1-GM5. Four fractions (GM1-GM4) were all blue pigments, and the first eluted higher molecular weight fraction GM1 had a higher tinctorial strength than the later eluted lower molecular weight fractions, GM2-GM4. The last eluted GM5 fraction with lambda(max) of 292 nm was colorless and was confirmed as the true intermediate of the blue pigments on the basis of UV-vis spectrophotometric evidence. The GM5 fraction was composed of two epimeric isomers, and their structures were characterized by (1)H NMR, (1)H-(1)H COSY, (13)C NMR, and HMQC and HMBC spectral measurements.

Topics: Gardenia; Iridoids; Isomerism; Methylamines; Molecular Weight; Pigments, Biological; Pyrans; Solubility

2002