iridoids and chimaphilin

To investigate the chemical constituents of Pyrola calliatha.. The chemical constituents were isolated by various column chromatographic methods. The structures were identified by spectral data.. Ten compounds were isolated and identified as chimaphilin (1), uvaol(2), ursolic acid (3), 2beta,3beta,23-trihydroxy-12-ene-28-ursolic acid (4), daucosterol (5), 2alpha,3beta,23,24-tetrahydroxy-12-ene-28-ursolic acid (6), emodin (7), gallic acid (8), monotropein (9), adenosine (10).. Compounds 2,4,6,7,10 were obtained from this genus for the first time, compounds 5, 9 were obtained from this species for the first time. Antifungal activity of compounds 1-4, 6-9 were evaluated. Compound 1 showed the strong activity.

Topics: Antifungal Agents; Cryptococcus neoformans; Iridoids; Naphthoquinones; Plants, Medicinal; Pyrola; Triterpenes