iridoids and baldrinal

iridoids has been researched along with baldrinal* in 5 studies

Other Studies

5 other study(ies) available for iridoids and baldrinal

ArticleYear
Valeridoids G - Q, Eleven seco-Iridoids from Valeriana jatamansi and Their Bioactivites.
    Chemistry & biodiversity, 2022, Volume: 19, Issue:9

    Eleven new seco-iridoids, valeridoids G-Q (1-6 and 8-12), along with four known products, 9-epi-valtral C (7), desacylbaldrinal (13), 11-methoxyviburtinal (14) and baldrinal (15), were obtained from Valeriana jatamansi. Among them, the new compounds were identified by their NMR, HR-ESI-MS spectroscopic data and ECD calculation. Moreover, valeridoid N and O were a pair of C

    Topics: Ethers; Humans; Iridoids; Molecular Structure; Nitric Oxide; Plant Roots; Valerian

2022
The Anticonvulsant Effects of Baldrinal on Pilocarpine-Induced convulsion in Adult Male Mice.
    Molecules (Basel, Switzerland), 2019, Apr-24, Volume: 24, Issue:8

    Epilepsy is a prevalent neurological disorder that was reported to affect about 56 million people in the world. Approximately one-third of the epileptic patients that suffer from seizures do not receive effective medical treatment. The aim of this study was to determine the potential anticonvulsant activities of Baldrinal (BAL) with a mouse model of pilocarpine (PILO)-induced epilepsy. The mice were treated with different doses of BAL or sodium valproate prior to PILO injection. Spontaneous and evoked seizures were evaluated from EEG recordings, and their severity was tested by the Racine scale. In addition, the brain tissues were analyzed for histological changes, and the in situ levels of glutamic acid (Glu) and gamma-aminobutyric acid (GABA) were also measured. Activation of astrocytes in the hippocampus was measured. PILO-treated mice showed a significant increase in Glu levels, which was restored by BAL. In addition, BAL treatment also reduced the rate of seizures in the epileptic mice, and ameliorated the increased levels of NMDAR

    Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Iridoids; Mice; Pilocarpine; Seizures

2019
[Effects of baldrinal of Valeriana jatamansi on expression of CRF, TPH1 mRNA and 5-HT in rats with irritable bowel syndrome].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2017, Volume: 42, Issue:2

    This study aimed to investigate the effects of baldrinal of Valeriana jatamansi on the expression of corticotropin releasing factor (CRF) and tryptophan hydroxylase 1 (TPH1) mRNA and levels of 5-hydroxytryptamine (5-HT) in colon of rats with irritable bowel syndrome (IBS), and to explain its therapeutic mechanism on IBS through 5-HT pathway. Fifty-four male SD rats were randomly divided into 6 groups: blank group, model group, baldrinal high, medium and low dose groups, and pinaverium bromide group, n=9 in each group. The IBS rat models were established by using unpredictable chronic stress for 3 weeks followed by 1-hour acute restraint stress (CAS) after 7 days of rest and independent feeding. CRF expression was detected by IHC-P; TPH1 mRNA expression was detected by using RT-PCR and the 5-HT level was measured by high performance liquid chromatography(HPLC). The results indicated that the method of chronic stress with acute restrain stress method and independent feeding could lead to the increase in expressions of CRF and TPH1 mRNA and levels of 5-HT in IBS rats(P<0.05). The expressions of CRF, TPH1 mRNA and 5-HT in baldrinal groups were significantly lower than those in model group(P<0.05). The experimental results showed that IBS could result in increase in the expressions of CRF, TPH1 mRNA and levels of 5-HT, and the baldrinal of V. jatamansi could improve the symptoms of IBS by reducing the expressions of CRF, TPH1 mRNA and levels of 5-HT in colon of rats.

    Topics: Animals; Colon; Corticotropin-Releasing Hormone; Iridoids; Irritable Bowel Syndrome; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Serotonin; Tryptophan Hydroxylase; Valerian

2017
Three decomposition products of valepotriates from Valeriana jatamansi and their cytotoxic activity.
    Journal of Asian natural products research, 2015, Volume: 17, Issue:5

    Three new decomposition products of valepotriates, valtrals A-C (1-3), and two known products, baldrinal and homobaldrinal, are formed during the isolation procedure of the ethanol extract of the whole plants of Valeriana jatamansi. Their structures were determined by spectroscopic methods including IR, MS, 1D, and 2D NMR experiments. Compounds 1-3 showed selective cytotoxicity against metastatic prostate cancer (PC-3M) and colon cancer (HCT-8) cell lines.

    Topics: Antineoplastic Agents, Phytogenic; Colonic Neoplasms; Drugs, Chinese Herbal; Humans; Iridoids; Male; Molecular Structure; Nardostachys; Nuclear Magnetic Resonance, Biomolecular; Prostatic Neoplasms; Valerian

2015
[The effect of baldrinal on hematoipoetic cells in vitro, on the metabolic activity of the liver in vivo and on its analysis in proprietary drugs].
    Planta medica, 1986, Issue:6

    Topics: Animals; Hematopoietic Stem Cells; Iridoids; Liver; Mice; Pyrans; Tranquilizing Agents

1986