ipsapirone has been researched along with gepirone in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (42.22) | 18.7374 |
| 1990's | 23 (51.11) | 18.2507 |
| 2000's | 3 (6.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cegła, MT; Duszyńska, B; Mokrosz, JL; Pietrasiewicz, M | 1 |
| Becker, OM; Chen, D; Cheruku, S; Dhanoa, DS; Fichman, M; Heifetz, A; Kauffman, M; Marantz, Y; Mohanty, P; Noiman, S; Nudelman, R; Shacham, S; Sharadendu, A | 1 |
| Cleves, AE; Jain, AN; Kirshner, D; Langham, JJ; Spitzer, R | 1 |
| Allen, T; Grahame-Smith, DG; Grasby, PM; Kelly, PA; Sharp, T | 1 |
| Heal, DJ; Hearson, M; Martin, KF; Phillips, I; Prow, MR | 1 |
| Rigdon, GC; Weatherspoon, JK | 1 |
| Kelder, D; Ross, SB | 1 |
| Moon, SL; Taylor, DP | 1 |
| Anderson, IM; Cowen, PJ; Grahame-Smith, DG | 1 |
| Fischette, C; Hamik, A; Oksenberg, D; Peroutka, SJ | 1 |
| Sanger, DJ | 1 |
| Danek, L; Daniel, W; Melzacka, M; Nocon, H | 1 |
| Eison, AS; Margraf, RR; Wright, RN; Yocca, FD | 1 |
| Colpaert, FC; Millan, MJ | 1 |
| Davies, M; Fletcher, PJ | 1 |
| Bielenberg, GW; Burkhardt, M | 1 |
| Bode-Greuel, KM; Glaser, T; Horváth, E; Klisch, J; Traber, J | 1 |
| Meltzer, HY; Nash, JF | 1 |
| Boyer, WF; Feighner, JP | 1 |
| Engel, JA; Hjorth, S; Söderpalm, B | 1 |
| Hirose, A; Kumasaka, Y; Nakamura, M; Shimizu, H; Tanaka, H; Tatsuno, T | 1 |
| Rodgers, RJ; Shepherd, JK | 1 |
| Cooper, SJ; Desa, A | 1 |
| Gorzalka, BB; Mendelson, SD | 1 |
| Andrade, R; Nicoll, RA | 1 |
| Giral, P; Martin, P; Simon, P; Soubrié, P | 1 |
| Dourish, CT; Gilbert, F | 1 |
| Brazell, C; Gilbert, F; Stahl, SM; Tricklebank, MD | 1 |
| Gudelsky, GA; Koenig, JI; Meltzer, HY | 1 |
| Bianchi, G; Caccia, S; Della Vedova, F; Garattini, S | 1 |
| Anderson, MC; Chung, E; Van Woert, MH | 1 |
| Brazell, C; Dourish, CT; Gilbert, F; McClue, S; Stahl, SM | 1 |
| Bianchi, G; Caccia, S | 1 |
| Geyer, MA; Mansbach, RS | 1 |
| Geiger, G; Grimes, D; Heaslip, RJ; Henry, DE; Lee, DK; Rimele, TJ | 1 |
| Cooper, SJ; Neill, JC | 1 |
| Matheson, GK; Michel, C; Pfeifer, DM; Weiberg, MB | 1 |
| Lum-Ragan, JT; Piercey, MF; Smith, MW | 1 |
| Ciccocioppo, R; Cooper, SJ | 1 |
| Bohmaker, K; Eison, AS; Meller, E; Yocca, FD | 1 |
| Korneyev, AY; Seredenin, SB | 1 |
| Jantos, H; Monti, JM; Reyes-Parada, M; Scorza, C; Silveira, R | 1 |
| Azzaro, AJ; Fox, JL; Johnson, EA | 1 |
| Dourish, CT; Stanhope, KJ | 1 |
| Eckler, JR; Rabin, RA; Reissig, CJ; Winter, JC | 1 |
3 review(s) available for ipsapirone and gepirone
| Article | Year |
|---|---|
Buspirone and related compounds as alternative anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Binding Sites; Buspirone; Humans; Isoindoles; Piperazines; Pyrimidines; Receptors, Serotonin; Structure-Activity Relationship | 1991 |
Neuroendocrine effects of azapirones.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Dose-Response Relationship, Drug; Humans; Neurosecretory Systems; Pyrimidines; Receptors, Serotonin | 1990 |
Serotonin-1A anxiolytics: an overview.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Brain; Buspirone; Clinical Trials as Topic; Double-Blind Method; Humans; Isoindoles; Piperazines; Pyrimidines; Receptors, Serotonin | 1989 |
2 trial(s) available for ipsapirone and gepirone
| Article | Year |
|---|---|
Buspirone and related compounds as alternative anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Binding Sites; Buspirone; Humans; Isoindoles; Piperazines; Pyrimidines; Receptors, Serotonin; Structure-Activity Relationship | 1991 |
Serotonin-1A anxiolytics: an overview.
Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Brain; Buspirone; Clinical Trials as Topic; Double-Blind Method; Humans; Isoindoles; Piperazines; Pyrimidines; Receptors, Serotonin | 1989 |
42 other study(ies) available for ipsapirone and gepirone
| Article | Year |
|---|---|
Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Central Nervous System; Hydrocarbons; Piperazines; Radioligand Assay; Rats; Receptors, Serotonin; Structure-Activity Relationship; Substrate Specificity; Tetrahydronaphthalenes | 1992 |
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Binding, Competitive; Biological Availability; Cell Line; Clinical Trials, Phase I as Topic; Dogs; Drug Design; Half-Life; Humans; In Vitro Techniques; Male; Mice; Microsomes, Liver; Models, Molecular; Patch-Clamp Techniques; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Sulfonamides | 2006 |
Physical binding pocket induction for affinity prediction.
Topics: Binding Sites; Ligands; Models, Molecular; Neural Networks, Computer; Peptide Fragments; Protein Binding; Receptor, Serotonin, 5-HT1A | 2009 |
Effects of the 5-HT1A partial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat.
Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Blood Pressure; Body Temperature; Brain Chemistry; Buspirone; Deoxyglucose; Glucose; Male; Pyrimidines; Rats; Rats, Inbred Strains | 1992 |
Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Body Temperature; Buspirone; Dose-Response Relationship, Drug; Down-Regulation; Hypothermia; Male; Mice; Mice, Inbred C57BL; Parasympatholytics; Pyrimidines; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1992 |
5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Buspirone; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Methoxydimethyltryptamines; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Reflex, Startle; Schizophrenia; Serotonin Receptor Agonists | 1992 |
Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Corticosterone; Drug Interactions; Hydrocortisone; Injections; Male; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Serotonin Receptor Agonists; Time Factors | 1992 |
Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites.
Topics: Adenylyl Cyclases; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Buspirone; Isoindoles; Male; Piperazines; Pyrimidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Dopamine; Receptors, Serotonin | 1990 |
Effects of buspirone and related compounds on suppressed operant responding in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Buspirone; Chlordiazepoxide; Conditioning, Operant; Dioxanes; Idazoxan; Injections, Intraperitoneal; Male; Pyrimidines; Rats; Rats, Inbred Strains | 1990 |
Cerebral pharmacokinetics of ipsapirone in rats after different routes of administration.
Topics: Administration, Oral; Animals; Anti-Anxiety Agents; Biotransformation; Brain; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Ethylmorphine-N-Demethylase; Half-Life; Injections, Intraperitoneal; Male; Microsomes, Liver; Proadifen; Pyrimidines; Rats; Rats, Inbred Strains | 1990 |
8-OH-DPAT and buspirone analogs inhibit the ketanserin-sensitive quipazine-induced head shake response in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Head; Ketanserin; Male; Naphthalenes; Pindolol; Pyrimidines; Quinolines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Stereotyped Behavior; Tetrahydronaphthalenes | 1990 |
Attenuation of opioid induced antinociception by 5-HT1A partial agonists in the rat.
Topics: Alprenolol; Analgesics; Animals; Buspirone; Fentanyl; Male; Morphine; Narcotics; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Serotonin; Spiperone; Sufentanil | 1990 |
The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dopamine; Dose-Response Relationship, Drug; Eating; Fenclonine; Haloperidol; Male; Pyrimidines; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Tetrahydronaphthalenes | 1990 |
5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Indoles; Ischemic Attack, Transient; Mice; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Serotonin; Tetrahydronaphthalenes | 1990 |
Effects of 5-hydroxytryptamine1A-receptor agonists on hippocampal damage after transient forebrain ischemia in the Mongolian gerbil.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cell Survival; Gerbillinae; Hippocampus; Indoles; Ischemic Attack, Transient; Neurons; Pyrimidines; Receptors, Serotonin; Tetrahydronaphthalenes | 1990 |
Effect of gepirone and ipsapirone on the stimulated and unstimulated secretion of prolactin in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; alpha-Methyltyrosine; Animals; Anti-Anxiety Agents; Electric Stimulation; Haloperidol; Male; Methoxydimethyltryptamines; Methyltyrosines; Prolactin; Pyrazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Tetrahydronaphthalenes | 1989 |
Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test.
Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Conflict, Psychological; Male; Motor Activity; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1989 |
Effects of the putative anxiolytic SM-3997 on central monoaminergic systems.
Topics: Animals; Anti-Anxiety Agents; Biogenic Monoamines; Brain; Brain Chemistry; Buspirone; Dopamine; Imipramine; Isoindoles; Male; Norepinephrine; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin | 1989 |
Prevention of the analgesic consequences of social defeat in male mice by 5-HT1A anxiolytics, buspirone, gepirone and ipsapirone.
Topics: Analgesia; Animals; Anti-Anxiety Agents; Buspirone; Male; Mice; Mice, Inbred DBA; Nociceptors; Pindolol; Pyrimidines; Reaction Time; Social Behavior | 1989 |
Benzodiazepines and putative 5-HT1A agonists increase hypertonic saline consumption in rehydrating rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Benzodiazepines; Drinking; Male; Midazolam; Naphthalenes; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Serotonin; Saline Solution, Hypertonic; Self Administration; Sodium Chloride; Tetrahydronaphthalenes | 1987 |
Effects of 5-HT1A selective anxiolytics on lordosis behavior: interactions with progesterone.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Drug Interactions; Estrogens; Posture; Progesterone; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sexual Behavior, Animal; Tetrahydronaphthalenes | 1986 |
Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neurons; Pyramidal Tracts; Pyrimidines; Rats; Receptors, Serotonin; Synapses; Tetrodotoxin | 1987 |
Reversal of helpless behavior in rats by putative 5-HT1A agonists.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Avoidance Learning; Buspirone; Escape Reaction; Helplessness, Learned; Male; Naphthalenes; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1988 |
Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Eating; Hyperphagia; Male; Naphthalenes; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1987 |
Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Buspirone; Male; Physostigmine; Pindolol; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes | 1988 |
5-Hydroxytryptamine1A receptor-mediated effects of buspirone, gepirone and ipsapirone.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Corticosterone; Hypothermia, Induced; Male; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin | 1988 |
The alpha 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP).
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Buspirone; Chromatography, High Pressure Liquid; Clonidine; Drug Interactions; Gastrointestinal Transit; Injections, Intravenous; Male; Pyrimidines; Rats | 1988 |
Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Drug Synergism; Male; Olivary Nucleus; Pyridines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Seizures; Strychnine; Syndrome | 1988 |
Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Body Weight; Brain; Buspirone; Eating; Male; Naphthalenes; Pyrimidines; Rats; Receptors, Serotonin; Tetrahydronaphthalenes | 1988 |
Simultaneous determination of buspirone, gepirone, ipsapirone and their common metabolite 1-(2-pyrimidinyl)piperazine in rat plasma and brain by high-performance liquid chromatography.
Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Buspirone; Male; Pyrimidines; Rats; Spectrophotometry, Ultraviolet | 1988 |
Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Male; Methysergide; Naphthalenes; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reflex, Startle; Tetrahydronaphthalenes | 1988 |
Tissue-dependent alpha adrenoceptor activity of buspirone and related compounds.
Topics: Animals; Buspirone; Cerebral Cortex; Clonidine; Guinea Pigs; Male; Norepinephrine; Phenylephrine; Prazosin; Pyrimidines; Rabbits; Rats; Receptors, Adrenergic, alpha; Vas Deferens | 1987 |
MDL 72832, a selective 5-HT1A receptor ligand, stereospecifically increases food intake.
Topics: Animals; Eating; Male; Pyrimidines; Rats; Receptors, Serotonin; Spiro Compounds; Stereoisomerism | 1988 |
The effects of azapirones on serotonin1A neurons of the dorsal raphe.
Topics: Animals; Buspirone; Dose-Response Relationship, Drug; Isoindoles; Male; Piperazines; Pyrimidines; Raphe Nuclei; Rats; Receptors, Serotonin; Serotonin Receptor Agonists | 1994 |
Excitation of noradrenergic cell firing by 5-hydroxytryptamine1A agonists correlates with dopamine antagonist properties.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dopamine; Dopamine Antagonists; Haloperidol; Locus Coeruleus; Male; Neurons; Norepinephrine; Pyrimidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists; Substantia Nigra | 1994 |
Effects of selective 5-HT1 receptor agonists in water-deprived rats on salt intake in two-choice tests.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Male; Piperazines; Pyrimidines; Rats; Receptors, Serotonin; Serotonin Receptor Agonists; Sodium Chloride; Taste; Water Deprivation | 1993 |
Comparative effects of chronic 8-OH-DPAT, gepirone and ipsapirone treatment on the sensitivity of somatodendritic 5-HT1A autoreceptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Chromatography, High Pressure Liquid; Dendrites; Dose-Response Relationship, Drug; Male; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin | 1993 |
Effect of 5-HT-1A receptor agonists on paw licking reaction on hot plate and unpunished drinking in rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Drinking Behavior; Indoles; Male; Pain; Prosencephalon; Punishment; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Thirst; Time Factors | 1993 |
Sleep and waking in 5,7-DHT-lesioned or (-)-pindolol-pretreated rats after administration of buspirone, ipsapirone, or gepirone.
Topics: 5,7-Dihydroxytryptamine; Adrenergic beta-Antagonists; Animals; Biogenic Monoamines; Brain Chemistry; Buspirone; Dose-Response Relationship, Drug; Male; Pindolol; Pyrimidines; Rats; Rats, Wistar; Serotonin Agents; Serotonin Receptor Agonists; Sleep; Sleep, REM; Wakefulness | 1995 |
The anxiolytic serotonin 5-HT1A receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum.
Topics: Animals; Anti-Anxiety Agents; Buspirone; Dopamine Antagonists; Enzyme Inhibitors; Male; Neostriatum; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists; Sulpiride; Synaptosomes; Tyrosine 3-Monooxygenase | 1996 |
Effects of 5-HT1A receptor agonists, partial agonists and a silent antagonist on the performance of the conditioned emotional response test in the rat.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Behavior, Animal; Chlordiazepoxide; Conditioning, Operant; Diazepam; Electroshock; Food Deprivation; Male; Muscarinic Antagonists; Piperazines; Pyridines; Pyrimidines; Rats; Receptors, Serotonin; Scopolamine; Serotonin Agents; Serotonin Antagonists | 1996 |
The 5-HT1A receptor and the stimulus effects of LSD in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dose-Response Relationship, Drug; Lysergic Acid Diethylamide; Male; Piperazines; Pyridines; Pyrimidines; Rats; Rats, Inbred F344; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists | 2005 |