Page last updated: 2024-08-24

ipsapirone and buspirone

ipsapirone has been researched along with buspirone in 102 studies

Research

Studies (102)

Timeframe	Studies, this research(%)	All Research%
pre-1990	33 (32.35)	18.7374
1990's	59 (57.84)	18.2507
2000's	8 (7.84)	29.6817
2010's	2 (1.96)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abou-Gharbia, M; Andree, T; Haskins, JT; Moyer, JA; Patel, U; Schiehser, G; Webb, M	1
Abou-Gharbia, M; Andree, TH; Moyer, JA; Muth, EA; Patel, UR; Webb, MB	1
Glennon, RA	1
Chilmonczyk, Z; Cybulski, J; Gdaniec, M; Kozioł, AE; Leś, A; Woźniakowska, A	1
Adam, G; Caignard, DH; Guardiola-Lemaître, B; Guillaumet, G; Pfeiffer, B; Podona, T; Renard, P	1
Adam, G; Baudin, ML; Caignard, DH; Comoy, C; Guardiola-Lemaitre, B; Guillaumet, G; Marot, C; Morin-Allory, L; Pfeiffer, B; Podona, T; Renard, P; Rettori, MC	1
Chaput, C; Millan, MJ; Newman-Tancredi, A; Verrièle, L	1
Audinot, V; Chaput, C; Conte, C; Gavaudan, S; Millan, MJ; Newman-Tancredi, A; Touzard, M; Verrièle, L	1
Becker, OM; Chen, D; Cheruku, S; Dhanoa, DS; Fichman, M; Heifetz, A; Kauffman, M; Marantz, Y; Mohanty, P; Noiman, S; Nudelman, R; Shacham, S; Sharadendu, A	1
Amato, ME; Bojarski, AJ; Cagnotto, A; Mennini, T; Mereghetti, I; Modica, MN; Nowak, M; Pittalà, V; Romeo, G; Salerno, L; Siracusa, MA	1
Cleves, AE; Jain, AN; Kirshner, D; Langham, JJ; Spitzer, R	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Jaśkowska, J; Kułaga, D; Satała, G	1
Allen, T; Grahame-Smith, DG; Grasby, PM; Kelly, PA; Sharp, T	1
Sanger, DJ	2
Castañeda-Hernández, G; Fernández-Guasti, A; López-Rubalcava, C; Pérez-Urizar, J	1
Costall, B; Domeney, AM; Farre, AJ; Kelly, ME; Martinez, L; Naylor, RJ	1
Alvarez Sanz, MC; Levy, AD; Li, Q; Rittenhouse, PA; Van de Kar, LD	1
Murthy, JN; Pranzatelli, MR	1
Heal, DJ; Hearson, M; Martin, KF; Phillips, I; Prow, MR	1
Rigdon, GC; Weatherspoon, JK	1
Kelder, D; Ross, SB	1
Moon, SL; Taylor, DP	1
Inoue, Y; Ohno, M; Shibata, S; Teshima, K; Tominaga, K; Ueki, S; Ushio, M; Watanabe, S; Yamamoto, T	1
Lucki, I	1
Broderick, PA; Piercey, MF	1
Baudrie, V; Bluet-Pajot, MT; Broqua, P; Chaouloff, F	1
Brown, CM; Redfern, WS; Small, C; Spedding, M	1
Bohmaker, K; Goldstein, M; Meller, E	1
Francès, H; Khidichian, F; Monier, C	1
Anderson, IM; Cowen, PJ; Grahame-Smith, DG	1
Fischette, C; Hamik, A; Oksenberg, D; Peroutka, SJ	1
Fernández-Guasti, A; Picazo, O	1
Eison, AS; Margraf, RR; Wright, RN; Yocca, FD	1
Colpaert, FC; Millan, MJ	1
Davies, M; Fletcher, PJ	1
Bielenberg, GW; Burkhardt, M	1
Kalkman, HO; Soar, J	1
Coke, JA; McMillen, BA; Sanghera, MK; Williams, HL	1
Baudrie, V; Chaouloff, F; Laude, D	1
Caruso, J; Molino, LJ; Shemer, AV; Whitaker-Azmitia, PM	1
Bradbury, AJ; Higgins, GA; Jones, BJ; Oakley, NR	1
Berendsen, HH; Broekkamp, CL; Jenck, F	1
Boyer, WF; Feighner, JP	1
Engel, JA; Hjorth, S; Söderpalm, B	1
Hirose, A; Kumasaka, Y; Nakamura, M; Shimizu, H; Tanaka, H; Tatsuno, T	1
Rodgers, RJ; Shepherd, JK	1
Peroutka, SJ	1
Gardner, CR	1
Anwyl, R; Rowan, MJ	1
Gorzalka, BB; Mendelson, SD	1
Spencer, DG; Traber, J	1
Fozard, JR; Kidd, EJ; Neill, J; Tricklebank, MD	1
Curzon, G; Dourish, CT; Kennett, GA	1
Gonzales, DA; Peroutka, SJ; Shapiro, M	1
Bockaert, J; Bouhelal, R; Cory, RN; Dumuis, A; Sebben, M	1
Andrade, R; Nicoll, RA	1
Giral, P; Martin, P; Simon, P; Soubrié, P	1
Dourish, CT; Gilbert, F	1
Cassella, JV; Davis, M; Kehne, JH	1
Brazell, C; Gilbert, F; Stahl, SM; Tricklebank, MD	1
Gudelsky, GA; Koenig, JI; Meltzer, HY	1
Bianchi, G; Caccia, S; Della Vedova, F; Garattini, S	1
Hiner, BC; Kocsis, JD; Mauk, MD; Peroutka, SJ	1
Anderson, MC; Chung, E; Van Woert, MH	1
Brazell, C; Dourish, CT; Gilbert, F; McClue, S; Stahl, SM	1
Bianchi, G; Caccia, S	1
Peroutka, SJ; Smith, LM	1
Gallagher, JP; Joëls, M; Shinnick-Gallagher, P	1
Geyer, MA; Mansbach, RS	1
Geiger, G; Grimes, D; Heaslip, RJ; Henry, DE; Lee, DK; Rimele, TJ	1
Berger, M; Roed, I; von Wegerer, J; Walden, J	1
Berlin, I; Cesselin, F; Chalon, S; Payan, C; Puech, AJ; Schöllnhammer, G; Varoquaux, O	1
Evenden, JL; Petterson, M; Ryan, CN	1
Abramets, II; Kharin, NA; Komissarov, IV; Samoĭlovich, IM	1
Bramwell, S; Hjorth, S; McQuade, R; Sharp, T	1
Hong, E; Meneses, A	1
De Vry, J; Schreiber, R	1
Matheson, GK; Michel, C; Pfeifer, DM; Weiberg, MB	1
Maes, M; Meltzer, HY	1
Lum-Ragan, JT; Piercey, MF; Smith, MW	1
Bagdy, G; Kalogeras, KT	1
Korneyev, AY; Seredenin, SB	1
Sánchez, C	1
Jantos, H; Monti, JM; Reyes-Parada, M; Scorza, C; Silveira, R	1
Bobadilla, RA; Castillo, C; Castillo, EF; Hong, E; Ibarra, M	1
Hong, E; Ramírez-San Juan, E; Terrón, JA; Villalón, CM	1
Azzaro, AJ; Fox, JL; Johnson, EA	1
Fijał, K; Gołembiowska, K; Maćkowiak, M; Wedzony, K	2
Matheson, GK; Raess, BU; Tunnicliff, G	1
Herremans, AH; Mos, J; Olivier, B; Van Drimmelen, M; Van Hest, A	1
Grunze, H; Walden, J	1
Fernández-Guasti, A; López-Rubalcava, C	1
de Boer, SF; Koolhaas, JM; Lesourd, M; Mocaer, E	1
Cruz, SL; Fernández-Guasti, A; López-Rubalcava, C	1
Druse, MJ; Eriksen, JL; Gillespie, RA	1
Gorman, JM	1
Alekseyenko, OV; Avgustinovich, DF; Koryakina, LA	1
Eckler, JR; Rabin, RA; Reissig, CJ; Winter, JC	1
Allen, MH; Batista Miralha da Cunha, AB; Chessick, CA; de Lima, MS; dos Santos Souza, JJ; Kapczinski, FF; Thase, M	1

Reviews

7 review(s) available for ipsapirone and buspirone

Article	Year
Central serotonin receptors as targets for drug research. Journal of medicinal chemistry, 1987, Volume: 30, Issue:1 Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin	1987
Buspirone and related compounds as alternative anxiolytics. Neuropeptides, 1991, Volume: 19 Suppl Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Binding Sites; Buspirone; Humans; Isoindoles; Piperazines; Pyrimidines; Receptors, Serotonin; Structure-Activity Relationship	1991
Behavioral studies of serotonin receptor agonists as antidepressant drugs. The Journal of clinical psychiatry, 1991, Volume: 52 Suppl Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Buspirone; Clinical Trials as Topic; Depressive Disorder; Humans; Isoindoles; Piperazines; Pyrimidines; Rats; Receptors, Serotonin	1991
Neuroendocrine effects of azapirones. Journal of clinical psychopharmacology, 1990, Volume: 10, Issue:3 Suppl Topics: Animals; Anti-Anxiety Agents; Buspirone; Dose-Response Relationship, Drug; Humans; Neurosecretory Systems; Pyrimidines; Receptors, Serotonin	1990
Serotonin-1A anxiolytics: an overview. Psychopathology, 1989, Volume: 22 Suppl 1 Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Brain; Buspirone; Clinical Trials as Topic; Double-Blind Method; Humans; Isoindoles; Piperazines; Pyrimidines; Receptors, Serotonin	1989
Treatment of generalized anxiety disorder. The Journal of clinical psychiatry, 2002, Volume: 63 Suppl 8 Topics: Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Tricyclic; Anxiety Disorders; Benzodiazepines; Buspirone; Clinical Trials as Topic; Cognitive Behavioral Therapy; Cyclohexanols; Follow-Up Studies; Humans; Paroxetine; Psychotherapy; Pyrimidines; Relaxation Therapy; Selective Serotonin Reuptake Inhibitors; Treatment Outcome; Venlafaxine Hydrochloride	2002
Azapirones for generalized anxiety disorder. The Cochrane database of systematic reviews, 2006, Jul-19, Issue:3 Topics: Anti-Anxiety Agents; Antidepressive Agents; Anxiety Disorders; Benzodiazepines; Buspirone; Humans; Psychotherapy; Pyrimidines; Randomized Controlled Trials as Topic	2006

Trials

4 trial(s) available for ipsapirone and buspirone

Article	Year
Buspirone and related compounds as alternative anxiolytics. Neuropeptides, 1991, Volume: 19 Suppl Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Binding Sites; Buspirone; Humans; Isoindoles; Piperazines; Pyrimidines; Receptors, Serotonin; Structure-Activity Relationship	1991
Serotonin-1A anxiolytics: an overview. Psychopathology, 1989, Volume: 22 Suppl 1 Topics: Animals; Anti-Anxiety Agents; Anxiety Disorders; Brain; Buspirone; Clinical Trials as Topic; Double-Blind Method; Humans; Isoindoles; Piperazines; Pyrimidines; Receptors, Serotonin	1989
Evaluation of the alpha 2-adrenoceptor blocking properties of buspirone and ipsapirone in healthy subjects. Relationship with the plasma concentration of the common metabolite 1-(2-pyrimidinyl)-piperazine. British journal of clinical pharmacology, 1995, Volume: 39, Issue:3 Topics: Adrenergic alpha-Antagonists; Adult; Analysis of Variance; Anti-Anxiety Agents; Blood Pressure; Body Temperature; Buspirone; C-Peptide; Clonidine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Growth Hormone; Heart Rate; Humans; Insulin; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Pyrimidines; Serotonin Antagonists	1995
Effects of buspirone on plasma prolactin and cortisol levels in major depressed and normal subjects. Biological psychiatry, 1994, Mar-01, Volume: 35, Issue:5 Topics: Adult; Buspirone; Depressive Disorder; Dose-Response Relationship, Drug; Down-Regulation; Female; Humans; Hydrocortisone; Male; Middle Aged; Prolactin; Pyrimidines; Receptors, Serotonin; Serotonin Receptor Agonists; Sex Factors	1994

Other Studies

93 other study(ies) available for ipsapirone and buspirone

Article	Year
Synthesis and structure-activity relationship of substituted tetrahydro- and hexahydro-1,2-benzisothiazol-3-one 1,1-dioxides and thiadiazinones: potential anxiolytic agents. Journal of medicinal chemistry, 1989, Volume: 32, Issue:5 Topics: Animals; Anti-Anxiety Agents; Apomorphine; Avoidance Learning; Cyclic S-Oxides; In Vitro Techniques; Male; Rats; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Stereotyped Behavior; Structure-Activity Relationship; Thiadiazines; Thiazines; Thiazoles	1989
Polycyclic aryl- and heteroarylpiperazinyl imides as 5-HT1A receptor ligands and potential anxiolytic agents: synthesis and structure-activity relationship studies. Journal of medicinal chemistry, 1988, Volume: 31, Issue:7 Topics: Animals; Anti-Anxiety Agents; Apomorphine; Avoidance Learning; Behavior, Animal; Brain; Chemical Phenomena; Chemistry; Imides; Male; Piperazines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Stereotyped Behavior; Structure-Activity Relationship	1988
Buspirone analogues as ligands of the 5-HT1A receptor. 1. The molecular structure of buspirone and its two analogues. Journal of medicinal chemistry, 1995, May-12, Volume: 38, Issue:10 Topics: Buspirone; Carbon Isotopes; Cations; Electrochemistry; Ligands; Magnetic Resonance Spectroscopy; Molecular Structure; Piperazines; Protons; Receptors, Serotonin	1995
3,4-Dihydro-3-amino-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 1. Synthesis and structure--activity relationship studies. Journal of medicinal chemistry, 1994, Jun-10, Volume: 37, Issue:12 Topics: Animals; Anti-Anxiety Agents; Benzopyrans; Binding Sites; Brain; Columbidae; In Vitro Techniques; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Stereoisomerism; Structure-Activity Relationship	1994
3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]. Journal of medicinal chemistry, 1996, Oct-11, Volume: 39, Issue:21 Topics: Animals; Anti-Anxiety Agents; Benzopyrans; Colforsin; Cyclic AMP; Hippocampus; Maze Learning; Mice; Models, Molecular; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Spiro Compounds; Structure-Activity Relationship	1996
Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists. Naunyn-Schmiedeberg's archives of pharmacology, 1998, Volume: 357, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Affinity Labels; Animals; Binding, Competitive; CHO Cells; Cricetinae; Guanine Nucleotides; Hippocampus; Humans; Male; Membranes; Piperazines; Radiopharmaceuticals; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists	1998
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. European journal of pharmacology, 1998, Aug-21, Volume: 355, Issue:2-3 Topics: Animals; Antipsychotic Agents; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Agents; Sulfur Radioisotopes	1998
An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression. Journal of medicinal chemistry, 2006, Jun-01, Volume: 49, Issue:11 Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Binding, Competitive; Biological Availability; Cell Line; Clinical Trials, Phase I as Topic; Dogs; Drug Design; Half-Life; Humans; In Vitro Techniques; Male; Mice; Microsomes, Liver; Models, Molecular; Patch-Clamp Techniques; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Serotonin 5-HT1 Receptor Agonists; Structure-Activity Relationship; Sulfonamides	2006
Synthesis of new arylpiperazinylalkylthiobenzimidazole, benzothiazole, or benzoxazole derivatives as potent and selective 5-HT1A serotonin receptor ligands. Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15 Topics: Alkylation; Benzothiazoles; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Piperazine; Piperazines; Protein Binding; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Antagonists; Structure-Activity Relationship	2008
Physical binding pocket induction for affinity prediction. Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19 Topics: Binding Sites; Ligands; Models, Molecular; Neural Networks, Computer; Peptide Fragments; Protein Binding; Receptor, Serotonin, 5-HT1A	2009
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Design, synthesis and biological evaluation of novel serotonin and dopamine receptor ligands being 6-bromohexyl saccharine derivatives. Bioorganic & medicinal chemistry letters, 2019, 11-01, Volume: 29, Issue:21 Topics: Antidepressive Agents; Binding Sites; Dopamine Antagonists; Drug Evaluation, Preclinical; Ligands; Models, Molecular; Molecular Structure; Piperazines; Protein Binding; Receptors, Dopamine; Receptors, Serotonin; Saccharin; Serotonin; Serotonin Antagonists; Structure-Activity Relationship; Thermodynamics	2019
Effects of the 5-HT1A partial agonists gepirone, ipsapirone and buspirone on local cerebral glucose utilization in the conscious rat. Psychopharmacology, 1992, Volume: 106, Issue:1 Topics: Animals; Anti-Anxiety Agents; Autoradiography; Behavior, Animal; Blood Pressure; Body Temperature; Brain Chemistry; Buspirone; Deoxyglucose; Glucose; Male; Pyrimidines; Rats; Rats, Inbred Strains	1992
Increased rates of punished responding produced by buspirone-like compounds in rats. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:2 Topics: Animals; Anti-Anxiety Agents; Buspirone; Chlordiazepoxide; Conditioning, Operant; Dioxins; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Injections, Intravenous; Male; Punishment; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Spiro Compounds	1992
Evidence for a postsynaptic action of the serotonergic anxiolytics: ipsapirone, indorenate and buspirone. Brain research bulletin, 1992, Volume: 28, Issue:4 Topics: 5-Methoxytryptamine; 5,7-Dihydroxytryptamine; Animals; Anti-Anxiety Agents; Anxiety; Biogenic Monoamines; Brain Chemistry; Buspirone; Injections, Intraventricular; Male; Motor Activity; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin; Stereotaxic Techniques; Synapses	1992
Profile of action of a novel 5-hydroxytryptamine1A receptor ligand E-4424 to inhibit aversive behavior in the mouse, rat and marmoset. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Callithrix; Diazepam; Female; Guinea Pigs; Injections, Intraperitoneal; Male; Mice; Muscle Contraction; Muscle, Smooth; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Substance Withdrawal Syndrome	1992
Neuroendocrine responses to the serotonin2 agonist DOI are differentially modified by three 5-HT1A agonists. Neuropharmacology, 1992, Volume: 31, Issue:10 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Amphetamines; Animals; Anti-Anxiety Agents; Buspirone; Corticosterone; Male; Neurosecretory Systems; Prolactin; Pyrimidines; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Renin; Serotonin Receptor Agonists	1992
Brainstem 5-hydroxytrytamine1A binding sites are not down-regulated by agonists which induce tolerance in the rat: myoclonus and other serotonergic behaviors. Journal of receptor research, 1992, Volume: 12, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Brain Stem; Buspirone; Down-Regulation; Drug Tolerance; Male; Myoclonus; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes	1992
Characterization of 8-OH-DPAT-induced hypothermia in mice as a 5-HT1A autoreceptor response and its evaluation as a model to selectively identify antidepressants. British journal of pharmacology, 1992, Volume: 107, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antidepressive Agents; Body Temperature; Buspirone; Dose-Response Relationship, Drug; Down-Regulation; Hypothermia; Male; Mice; Mice, Inbred C57BL; Parasympatholytics; Pyrimidines; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists	1992
5-Hydroxytryptamine 1a receptor agonists block prepulse inhibition of acoustic startle reflex. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 263, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Buspirone; Dose-Response Relationship, Drug; Drug Interactions; Haloperidol; Male; Methoxydimethyltryptamines; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Reflex, Startle; Schizophrenia; Serotonin Receptor Agonists	1992
Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 346, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Corticosterone; Drug Interactions; Hydrocortisone; Injections; Male; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Sensitivity and Specificity; Serotonin Receptor Agonists; Time Factors	1992
[Behavioral pharmacological and electroencephalographic effects of the 5-HT1A partial agonist ipsapirone]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1991, Volume: 98, Issue:1 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Diazepam; Drug Synergism; Electroencephalography; Flumazenil; Male; Mice; Motor Activity; Pyrimidines; Rabbits; Rats; Rats, Inbred Strains; Serotonin	1991
5-HT1A agonists uncouple noradrenergic somatodendritic impulse flow and terminal release. Brain research bulletin, 1991, Volume: 27, Issue:5 Topics: Action Potentials; Analysis of Variance; Animals; Anti-Anxiety Agents; Buspirone; Dendrites; Hippocampus; Locus Coeruleus; Neurons; Norepinephrine; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin	1991
Buspirone, ipsapirone and 1-(2-pyrimidinyl)-piperazine decrease cold-induced thyrotropin secretion in rats. European journal of pharmacology, 1991, Nov-05, Volume: 204, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Buspirone; Cold Temperature; Hypothalamo-Hypophyseal System; Male; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes; Thyroid Gland; Thyrotropin	1991
The guinea-pig ileum preparation as a model for 5-HT1A receptors: anomalous effects with RS-30199-193. British journal of pharmacology, 1991, Volume: 104, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Azepines; Buspirone; Calcium; Drug Interactions; Female; Guinea Pigs; Ileum; In Vitro Techniques; Models, Biological; Muscle, Smooth; Naphthalenes; Phorbol 12,13-Dibutyrate; Pyrimidines; Radioligand Assay; Receptors, Serotonin; Reproducibility of Results; Spiro Compounds; Tetrahydronaphthalenes; Tryptamines	1991
Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists. Molecular pharmacology, 1990, Volume: 37, Issue:2 Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Cerebral Cortex; Hippocampus; Male; Piperazines; Pyrimidines; Quinolines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes	1990
Increase in the isolation-induced social behavioural deficit by agonists at 5-HT1A receptors. Neuropharmacology, 1990, Volume: 29, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Exploratory Behavior; Male; Mice; Motor Activity; Penbutolol; Piperazines; Pyrimidines; Receptors, Serotonin; Social Behavior; Social Isolation; Tetrahydronaphthalenes	1990
Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biological psychiatry, 1990, Jul-15, Volume: 28, Issue:2 Topics: Adenylyl Cyclases; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Buspirone; Isoindoles; Male; Piperazines; Pyrimidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Dopamine; Receptors, Serotonin	1990
Effects of buspirone and related compounds on suppressed operant responding in rats. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 254, Issue:2 Topics: Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Buspirone; Chlordiazepoxide; Conditioning, Operant; Dioxanes; Idazoxan; Injections, Intraperitoneal; Male; Pyrimidines; Rats; Rats, Inbred Strains	1990
The actions of diazepam and serotonergic anxiolytics vary according to the gender and the estrous cycle phase. Pharmacology, biochemistry, and behavior, 1990, Volume: 37, Issue:1 Topics: 5-Methoxytryptamine; Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Diazepam; Dose-Response Relationship, Drug; Female; Male; Metestrus; Proestrus; Pyrimidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Serotonin; Sex Factors	1990
8-OH-DPAT and buspirone analogs inhibit the ketanserin-sensitive quipazine-induced head shake response in rats. Pharmacology, biochemistry, and behavior, 1990, Volume: 35, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Head; Ketanserin; Male; Naphthalenes; Pindolol; Pyrimidines; Quinolines; Quipazine; Rats; Rats, Inbred Strains; Receptors, Serotonin; Stereotyped Behavior; Tetrahydronaphthalenes	1990
Attenuation of opioid induced antinociception by 5-HT1A partial agonists in the rat. Neuropharmacology, 1990, Volume: 29, Issue:3 Topics: Alprenolol; Analgesics; Animals; Buspirone; Fentanyl; Male; Morphine; Narcotics; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Serotonin; Spiperone; Sufentanil	1990
The involvement of 5-hydroxytryptaminergic and dopaminergic mechanisms in the eating induced by buspirone, gepirone and ipsapirone. British journal of pharmacology, 1990, Volume: 99, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dopamine; Dose-Response Relationship, Drug; Eating; Fenclonine; Haloperidol; Male; Pyrimidines; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Tetrahydronaphthalenes	1990
5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment. Stroke, 1990, Volume: 21, Issue:12 Suppl Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Indoles; Ischemic Attack, Transient; Mice; Pyrimidines; Rats; Rats, Inbred F344; Receptors, Serotonin; Tetrahydronaphthalenes	1990
Determination of the 5-HT receptor subtype involved in 8-OH-DPAT-induced hyperlocomotion: potential difficulties arising from inadequate pharmacological tools. European journal of pharmacology, 1990, Dec-04, Volume: 191, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dioxanes; Haloperidol; Male; Motor Activity; Pindolol; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Spiro Compounds; Tetrahydronaphthalenes	1990
Ipsapirone and 1-(2-pyrimidinyl)-piperazine increase rat locus coeruleus noradrenergic activity. Brain research bulletin, 1990, Volume: 24, Issue:1 Topics: Action Potentials; Animals; Brain; Buspirone; Clonidine; Dose-Response Relationship, Drug; Locus Coeruleus; Male; Norepinephrine; Pyrimidines; Rats; Rats, Inbred Strains	1990
Evidence that the 5-HT1A receptor agonists buspirone and ipsapirone activate adrenaline release in the conscious rat. European journal of pharmacology, 1990, Feb-20, Volume: 177, Issue:1-2 Topics: Animals; Blood Glucose; Buspirone; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Epinephrine; Male; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin	1990
Serotonergic agents restore appropriate decision-making in neonatal rats displaying dopamine D1 receptor-mediated vacillatory behavior. European journal of pharmacology, 1990, May-16, Volume: 180, Issue:2-3 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Animals, Newborn; Behavior, Animal; Buspirone; Clomipramine; Decision Making; Diazepam; Female; Pregnancy; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Serotonin	1990
Behavioural and biochemical consequences following activation of 5HT1-like and GABA receptors in the dorsal raphé nucleus of the rat. Neuropharmacology, 1988, Volume: 27, Issue:10 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Avoidance Learning; Body Temperature; Brain; Buspirone; Hydroxyindoleacetic Acid; Male; Muscimol; Posture; Pyrimidines; Raphe Nuclei; Rats; Rats, Inbred Strains; Receptors, GABA-A; Receptors, Serotonin; Social Behavior; Tetrahydronaphthalenes; Tissue Distribution	1988
Selective activation of 5HT1A receptors induces lower lip retraction in the rat. Pharmacology, biochemistry, and behavior, 1989, Volume: 33, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Dose-Response Relationship, Drug; Indoles; Lip; Male; Muscles; Naphthalenes; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1989
Effects of 5-HT1A receptor agonists and L-5-HTP in Montgomery's conflict test. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:1 Topics: 5-Hydroxytryptophan; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Conflict, Psychological; Male; Motor Activity; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes	1989
Effects of the putative anxiolytic SM-3997 on central monoaminergic systems. Pharmacology, biochemistry, and behavior, 1989, Volume: 32, Issue:4 Topics: Animals; Anti-Anxiety Agents; Biogenic Monoamines; Brain; Brain Chemistry; Buspirone; Dopamine; Imipramine; Isoindoles; Male; Norepinephrine; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin	1989
Prevention of the analgesic consequences of social defeat in male mice by 5-HT1A anxiolytics, buspirone, gepirone and ipsapirone. Psychopharmacology, 1989, Volume: 99, Issue:3 Topics: Analgesia; Animals; Anti-Anxiety Agents; Buspirone; Male; Mice; Mice, Inbred DBA; Nociceptors; Pindolol; Pyrimidines; Reaction Time; Social Behavior	1989
Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors. Biological psychiatry, 1985, Volume: 20, Issue:9 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Binding, Competitive; Brain; Buspirone; Cattle; Depression, Chemical; Diazepam; Flunitrazepam; In Vitro Techniques; Lorazepam; Pyrimidines; Receptors, Serotonin; Tetrahydronaphthalenes	1985
Recent developments in 5HT-related pharmacology of animal models of anxiety. Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:5 Topics: Animals; Anti-Anxiety Agents; Anxiety; Buspirone; Disease Models, Animal; Piperidines; Pyrimidines; Receptors, Serotonin; Ritanserin; Serotonin; Serotonin Antagonists; Social Behavior	1986
Neurophysiological effects of buspirone and isapirone in the hippocampus: comparison with 5-hydroxytryptamine. European journal of pharmacology, 1986, Dec-02, Volume: 132, Issue:1 Topics: Animals; Anti-Anxiety Agents; Buspirone; Electric Stimulation; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Pyrimidines; Rats; Rats, Inbred Strains; Serotonin; Spiperone	1986
Effects of 5-HT1A selective anxiolytics on lordosis behavior: interactions with progesterone. European journal of pharmacology, 1986, Dec-16, Volume: 132, Issue:2-3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Drug Interactions; Estrogens; Posture; Progesterone; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sexual Behavior, Animal; Tetrahydronaphthalenes	1986
The interoceptive discriminative stimuli induced by the novel putative anxiolytic TVX Q 7821: behavioral evidence for the specific involvement of serotonin 5-HT1A receptors. Psychopharmacology, 1987, Volume: 91, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Brain; Buspirone; Male; Methoxydimethyltryptamines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes	1987
Mediation of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) by the putative 5-HT1A receptor. European journal of pharmacology, 1987, Jan-06, Volume: 133, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Alprenolol; Animals; Buspirone; Discrimination Learning; Dose-Response Relationship, Drug; Generalization, Psychological; Male; Naphthalenes; Pindolol; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes	1987
Antidepressant-like action of 5-HT1A agonists and conventional antidepressants in an animal model of depression. European journal of pharmacology, 1987, Feb-24, Volume: 134, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Buspirone; Depressive Disorder; Disease Models, Animal; Drug Interactions; Indoles; Male; Motor Activity; Pyrimidines; Rats; Rats, Inbred Strains; Restraint, Physical; Serotonin; Stress, Psychological; Tetrahydronaphthalenes	1987
Modulation of postdecapitation convulsions in rats by alpha-adrenergic and 5-hydroxytryptamine1A agents. Experimental neurology, 1987, Volume: 96, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Agonists; Animals; Buspirone; Death; Dioxanes; Male; Prazosin; Pyrimidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Serotonin; Seizures; Serotonin; Tetrahydronaphthalenes; Yohimbine	1987
Piperazine derivatives including the putative anxiolytic drugs, buspirone and ipsapirone, are agonists at 5-HT1A receptors negatively coupled with adenylate cyclase in hippocampal neurons. Naunyn-Schmiedeberg's archives of pharmacology, 1987, Volume: 335, Issue:5 Topics: Adenylyl Cyclases; Animals; Anti-Anxiety Agents; Buspirone; Cells, Cultured; Colforsin; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Neurons; Pyrimidines; Receptors, Serotonin	1987
Novel anxiolytics discriminate between postsynaptic serotonin receptors mediating different physiological responses on single neurons of the rat hippocampus. Naunyn-Schmiedeberg's archives of pharmacology, 1987, Volume: 336, Issue:1 Topics: Animals; Anti-Anxiety Agents; Buspirone; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Neurons; Pyramidal Tracts; Pyrimidines; Rats; Receptors, Serotonin; Synapses; Tetrodotoxin	1987
Reversal of helpless behavior in rats by putative 5-HT1A agonists. Biological psychiatry, 1988, Feb-01, Volume: 23, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Avoidance Learning; Buspirone; Escape Reaction; Helplessness, Learned; Male; Naphthalenes; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes	1988
Effects of the novel anxiolytics gepirone, buspirone and ipsapirone on free feeding and on feeding induced by 8-OH-DPAT. Psychopharmacology, 1987, Volume: 93, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Eating; Hyperphagia; Male; Naphthalenes; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes	1987
Serotonin does not mediate anxiolytic effects of buspirone in the fear-potentiated startle paradigm: comparison with 8-OH-DPAT and ipsapirone. Psychopharmacology, 1988, Volume: 94, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Anti-Anxiety Agents; Buspirone; Conditioning, Operant; Fear; Fenclonine; Male; Pyrimidines; Raphe Nuclei; Rats; Rats, Inbred Strains; Reflex, Startle; Serotonin; Serotonin Antagonists; Tetrahydronaphthalenes	1988
Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration. European journal of pharmacology, 1988, Mar-15, Volume: 147, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Buspirone; Male; Physostigmine; Pindolol; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Tetrahydronaphthalenes	1988
5-Hydroxytryptamine1A receptor-mediated effects of buspirone, gepirone and ipsapirone. Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:4 Topics: Animals; Anti-Anxiety Agents; Buspirone; Corticosterone; Hypothermia, Induced; Male; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin	1988
The alpha 2-adrenoceptor antagonist activity of ipsapirone and gepirone is mediated by their common metabolite 1-(2-pyrimidinyl)-piperazine (PmP). European journal of pharmacology, 1988, Jul-14, Volume: 151, Issue:3 Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Anti-Anxiety Agents; Buspirone; Chromatography, High Pressure Liquid; Clonidine; Drug Interactions; Gastrointestinal Transit; Injections, Intravenous; Male; Pyrimidines; Rats	1988
Buspirone, 8-OH-DPAT and ipsapirone: effects on hippocampal cerebellar and sciatic fiber excitability. Brain research, 1988, Sep-27, Volume: 461, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Buspirone; Cerebellum; Evoked Potentials; Hippocampus; In Vitro Techniques; Male; Naphthalenes; Nerve Fibers; Organ Specificity; Pyrimidines; Rats; Rats, Inbred Strains; Sciatic Nerve; Serotonin; Tetrahydronaphthalenes	1988
Strychnine seizure potentiation by azaspirodecanedione anxiolytics in rats. European journal of pharmacology, 1988, Oct-18, Volume: 155, Issue:3 Topics: Animals; Anti-Anxiety Agents; Buspirone; Drug Synergism; Male; Olivary Nucleus; Pyridines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Seizures; Strychnine; Syndrome	1988
Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats. Psychoneuroendocrinology, 1988, Volume: 13, Issue:6 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenocorticotropic Hormone; Animals; Anti-Anxiety Agents; Body Weight; Brain; Buspirone; Eating; Male; Naphthalenes; Pyrimidines; Rats; Receptors, Serotonin; Tetrahydronaphthalenes	1988
Simultaneous determination of buspirone, gepirone, ipsapirone and their common metabolite 1-(2-pyrimidinyl)piperazine in rat plasma and brain by high-performance liquid chromatography. Journal of chromatography, 1988, Oct-14, Volume: 431, Issue:2 Topics: Animals; Anti-Anxiety Agents; Brain Chemistry; Buspirone; Male; Pyrimidines; Rats; Spectrophotometry, Ultraviolet	1988
Differential effects of 5-hydroxytryptamine1a selective drugs on the 5-HT behavioral syndrome. Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:6 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Behavior, Animal; Buspirone; Dose-Response Relationship, Drug; Methoxydimethyltryptamines; Pyrimidines; Rats; Receptors, Serotonin; Serotonin; Tetrahydronaphthalenes; Time Factors	1986
Effect of serotonin and serotonin analogues on passive membrane properties of lateral septal neurons in vitro. Brain research, 1987, Aug-04, Volume: 417, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Cell Membrane; Electric Conductivity; Fenfluramine; Male; Membrane Potentials; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Septum Pellucidum; Serotonin; Tetrahydronaphthalenes	1987
Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands. European journal of pharmacology, 1988, Nov-08, Volume: 156, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Male; Methysergide; Naphthalenes; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reflex, Startle; Tetrahydronaphthalenes	1988
Tissue-dependent alpha adrenoceptor activity of buspirone and related compounds. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 241, Issue:3 Topics: Animals; Buspirone; Cerebral Cortex; Clonidine; Guinea Pigs; Male; Norepinephrine; Phenylephrine; Prazosin; Pyrimidines; Rabbits; Rats; Receptors, Adrenergic, alpha; Vas Deferens	1987
Effects of the serotonin-1A agonists buspirone and ipsapirone on field potentials in the hippocampus slice: comparison with carbamzepine and verapamil. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1995, Volume: 5, Issue:1 Topics: Animals; Buspirone; Carbamazepine; Dose-Response Relationship, Drug; Evoked Potentials; Guinea Pigs; Hippocampus; Magnesium; Pyrimidines; Serotonin Receptor Agonists; Verapamil	1995
Effects of buspirone and ipsapirone on schedule induced polydipsia: comparison with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and raclopride. Psychopharmacology, 1993, Volume: 112, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Conditioning, Operant; Dopamine Antagonists; Drinking Behavior; Male; Pyrimidines; Raclopride; Rats; Rats, Sprague-Dawley; Reinforcement Schedule; Salicylamides; Serotonin Receptor Agonists	1993
[The different mechanism of the inhibition by buspirone and its camphorimide analogs of 5-HT3-serotoninergic effects]. Biulleten' eksperimental'noi biologii i meditsiny, 1993, Volume: 116, Issue:8 Topics: Animals; Anti-Anxiety Agents; Buspirone; Camphor; Creatinine; Depression, Chemical; Drug Combinations; Ganglia, Spinal; In Vitro Techniques; Membrane Potentials; Neurons; Piperazines; Pyrimidines; Rats; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists	1993
Effect of acute and repeated administration of 5-HT1A receptor agonists on 5-HT release in rat brain in vivo. Naunyn-Schmiedeberg's archives of pharmacology, 1993, Volume: 348, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Brain Chemistry; Buspirone; Dose-Response Relationship, Drug; Electrodes, Implanted; Electrophysiology; Hippocampus; Male; Microdialysis; Pindolol; Pyrimidines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists	1993
Modification of the anxiolytic effects of 5-HT1A agonists by shock intensity. Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:3 Topics: 5-Methoxytryptamine; Animals; Anti-Anxiety Agents; Buspirone; Conditioning, Operant; Conflict, Psychological; Diazepam; Electroshock; Male; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists	1993
Neuronal circuits involved in the anxiolytic effects of the 5-HT1A receptor agonists 8-OH-DPAT ipsapirone and buspirone in the rat. European journal of pharmacology, 1993, Nov-16, Volume: 249, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amygdala; Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Dose-Response Relationship, Drug; Electroshock; Hippocampus; Male; Pyrimidines; Raphe Nuclei; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Ultrasonics; Vocalization, Animal	1993
The effects of azapirones on serotonin1A neurons of the dorsal raphe. General pharmacology, 1994, Volume: 25, Issue:4 Topics: Animals; Buspirone; Dose-Response Relationship, Drug; Isoindoles; Male; Piperazines; Pyrimidines; Raphe Nuclei; Rats; Receptors, Serotonin; Serotonin Receptor Agonists	1994
Excitation of noradrenergic cell firing by 5-hydroxytryptamine1A agonists correlates with dopamine antagonist properties. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dopamine; Dopamine Antagonists; Haloperidol; Locus Coeruleus; Male; Neurons; Norepinephrine; Pyrimidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Receptor Agonists; Substantia Nigra	1994
Stimulation of 5-HT1A and 5-HT2/5-HT1C receptors induce oxytocin release in the male rat. Brain research, 1993, May-21, Volume: 611, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Buspirone; Male; Oxytocin; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Serotonin Receptor Agonists	1993
Effect of 5-HT-1A receptor agonists on paw licking reaction on hot plate and unpunished drinking in rat. Life sciences, 1993, Volume: 52, Issue:12 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Drinking Behavior; Indoles; Male; Pain; Prosencephalon; Punishment; Pyrimidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Receptor Agonists; Thirst; Time Factors	1993
Serotonergic mechanisms involved in the exploratory behaviour of mice in a fully automated two-compartment black and white text box. Pharmacology & toxicology, 1995, Volume: 77, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic beta-Antagonists; Animals; Anti-Anxiety Agents; Anxiety Disorders; Buspirone; Chlordiazepoxide; Darkness; Diazepam; Disease Models, Animal; Exploratory Behavior; Fenfluramine; Light; Male; Mice; Penbutolol; Propanolamines; Pyrimidines; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists	1995
Sleep and waking in 5,7-DHT-lesioned or (-)-pindolol-pretreated rats after administration of buspirone, ipsapirone, or gepirone. Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:2 Topics: 5,7-Dihydroxytryptamine; Adrenergic beta-Antagonists; Animals; Biogenic Monoamines; Brain Chemistry; Buspirone; Dose-Response Relationship, Drug; Male; Pindolol; Pyrimidines; Rats; Rats, Wistar; Serotonin Agents; Serotonin Receptor Agonists; Sleep; Sleep, REM; Wakefulness	1995
A comparative study of the effects of some 5-HT1A receptor agonists on the blood pressure of pithed rats. Archives of medical research, 1995,Autumn, Volume: 26, Issue:3 Topics: 5-Methoxytryptamine; Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Buspirone; Decerebrate State; Ketanserin; Male; Methoxamine; Pindolol; Prazosin; Pyrimidines; Quipazine; Rats; Rats, Wistar; Serotonin Receptor Agonists	1995
Role of alpha1-adrenoceptors in the reduction of external carotid blood flow induced by buspirone and ipsapirone in the dog. Life sciences, 1996, Volume: 58, Issue:1 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Flow Velocity; Blood Pressure; Buspirone; Carotid Artery, External; Depression, Chemical; Dogs; Female; Heart Rate; Male; Methiothepin; Methoxamine; Prazosin; Pyrimidines; Quipazine; Receptors, Adrenergic, alpha-1; Serotonin Antagonists; Serotonin Receptor Agonists; Sympathectomy; Vagus Nerve; Vasoconstriction	1996
The anxiolytic serotonin 5-HT1A receptor agonists buspirone, ipsapirone and gepirone are inhibitors of tyrosine hydroxylation in rat striatum. Behavioural brain research, 1996, Volume: 73, Issue:1-2 Topics: Animals; Anti-Anxiety Agents; Buspirone; Dopamine Antagonists; Enzyme Inhibitors; Male; Neostriatum; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists; Sulpiride; Synaptosomes; Tyrosine 3-Monooxygenase	1996
Ipsapirone enhances the dopamine outflow via 5-HT1A receptors in the rat prefrontal cortex. European journal of pharmacology, 1996, Jun-03, Volume: 305, Issue:1-3 Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Buspirone; Dopamine; Homovanillic Acid; Male; Microdialysis; Piperazines; Prefrontal Cortex; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists	1996
Effects of repeated doses of azapirones on rat brain 5-HT1A receptors and plasma corticosterone levels. General pharmacology, 1996, Volume: 27, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Buspirone; Calcium; Corticosterone; Dose-Response Relationship, Drug; Hypothalamo-Hypophyseal System; Neurons; Pituitary-Adrenal System; Pyrimidines; Raphe Nuclei; Rats; Receptors, Serotonin; Serotonin Receptor Agonists	1996
Evidence that conditioned stress enhances outflow of dopamine in rat prefrontal cortex: a search for the influence of diazepam and 5-HT1A agonists. Synapse (New York, N.Y.), 1996, Volume: 24, Issue:3 Topics: Animals; Anti-Anxiety Agents; Buspirone; Diazepam; Dopamine; Dose-Response Relationship, Drug; Fear; Male; Microdialysis; Prefrontal Cortex; Pyrimidines; Rats; Rats, Wistar; Serotonin Receptor Agonists; Stress, Psychological	1996
The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. European journal of pharmacology, 1997, May-01, Volume: 325, Issue:2-3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Columbidae; Discrimination Learning; Fluvoxamine; Indoles; Pindolol; Piperazines; Pyridines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles	1997
Reduction of the frequency of occurrence of low magnesium induced field potentials in the hippocampus slice preparation of guinea pigs: a good screening tool for calcium antagonistic effects of anticonvulsant and antipsychotic drugs. Magnesium research, 1997, Volume: 10, Issue:2 Topics: Animals; Anticonvulsants; Antipsychotic Agents; Buspirone; Calcium Channel Blockers; Carbamazepine; Drug Evaluation, Preclinical; Epilepsy; Female; Guinea Pigs; Hippocampus; In Vitro Techniques; Lamotrigine; Magnesium; Male; Pyrimidines; Pyrones; Triazines	1997
Modification of the anxiolytic action of 5-HT1A compounds by GABA-benzodiazepine agents in rats. Pharmacology, biochemistry, and behavior, 1998, Volume: 60, Issue:1 Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anti-Anxiety Agents; Anxiety; Bicuculline; Buspirone; Diazepam; Drug Interactions; Flumazenil; GABA Agonists; Male; Psychomotor Performance; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1	1998
Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: A comparative pharmacological study with 8-hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:3 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aggression; Animals; Behavior, Animal; Buspirone; Male; Piperazines; Pyridines; Pyrimidines; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Spiro Compounds	1999
Blockade of the anxiolytic-like action of ipsapirone and buspirone, but not that of 8-OH-DPAT, by adrenalectomy in male rats. Psychoneuroendocrinology, 1999, Volume: 24, Issue:4 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenal Medulla; Adrenalectomy; Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Male; Motor Activity; Pyrimidines; Rats; Rats, Wistar; Serotonin Agents	1999
Effects of in utero ethanol exposure and maternal treatment with a 5-HT(1A) agonist on S100B-containing glial cells. Brain research. Developmental brain research, 2000, Jun-30, Volume: 121, Issue:2 Topics: Animals; Buspirone; Calcium-Binding Proteins; Cell Count; Central Nervous System Depressants; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Gene Expression; In Situ Hybridization; Nerve Growth Factors; Neuroglia; Pregnancy; Prenatal Exposure Delayed Effects; Pyrimidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Serotonin Receptor Agonists	2000
Effects of chronic treatment with ipsapirone and buspirone on the C57BL/6J strain mice under social stress. Life sciences, 2003, Feb-14, Volume: 72, Issue:13 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Buspirone; Depression; Interpersonal Relations; Male; Mice; Mice, Inbred C57BL; Pyrimidines; Social Dominance; Social Environment; Stress, Psychological	2003
The 5-HT1A receptor and the stimulus effects of LSD in the rat. Psychopharmacology, 2005, Volume: 182, Issue:2 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Dose-Response Relationship, Drug; Lysergic Acid Diethylamide; Male; Piperazines; Pyridines; Pyrimidines; Rats; Rats, Inbred F344; Receptor, Serotonin, 5-HT1A; Serotonin 5-HT1 Receptor Agonists	2005