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ipsapirone and 1-(3-chlorophenyl)piperazine

ipsapirone has been researched along with 1-(3-chlorophenyl)piperazine in 21 studies

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19904 (19.05)18.7374
1990's11 (52.38)18.2507
2000's6 (28.57)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cegła, MT; Duszyńska, B; Mokrosz, JL; Pietrasiewicz, M1
Glennon, RA1
Soudijn, W; Tulp, MT; van Steen, BJ; van Wijngaarden, I1
Buck, LB; Petrascheck, M; Ye, X1
Cleves, AE; Jain, AN; Kirshner, D; Langham, JJ; Spitzer, R1
Barr, LC; Charney, DS; Goodman, WK; McDougle, CJ; Price, LH1
Edwards, E; Harkins, K; Whitaker-Azmitia, PM1
Agmo, A; Escalante, A; Fernández-Guasti, A1
Geyer, MA; Mansbach, RS1
Aghajanian, GK; Sprouse, JS1
Aulakh, CS; Hill, JL; Murphy, DL; Tolliver, T; Wozniak, KM1
Hepner, BC; Pomerantz, SM; Wertz, JM1
Ciccocioppo, R; Cooper, SJ1
Herremans, AH; Mos, J; Olivier, B; Van Drimmelen, M; Van Hest, A1
Baumgarten, HG; Grozdanovic, Z1
Bandelow, B; Bartmann, U; Broocks, A; George, A; Gleiter, CH; Hajak, G; Hillmer-Vogel, U; Meyer, D; Meyer, T; Rüther, E1
Garcia-Borreguero, D; Murphy, DL; Rosenthal, NE; Schwartz, PJ; Sedway, J; Turner, EH; Vetticad, RG; Wehr, TA1
Bandelow, B; Bartmann, U; Broocks, A; George, A; Gleiter, CH; Hajak, G; Jestrabeck, C; Meineke, I; Opitz, M; Roed, IS; Rüther, E1
Asmussen, M; de Vry, J; Hesse, D; Schreiber, R; Selbach, K1
Bandelow, B; Bartmann, U; Broocks, A; George, A; Gleiter, CH; Hillmer-Vogel, U; Meyer, T1
Griez, E; Klaassen, T; Menheere, PP; Riedel, WJ; van Praag, HM1

Reviews

3 review(s) available for ipsapirone and 1-(3-chlorophenyl)piperazine

ArticleYear
Central serotonin receptors as targets for drug research.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:1

    Topics: Animals; Humans; Receptors, Serotonin; Research Design; Serotonin

1987
The serotonin hypothesis of obsessive compulsive disorder: implications of pharmacologic challenge studies.
    The Journal of clinical psychiatry, 1992, Volume: 53 Suppl

    Topics: Biomarkers; Clomipramine; Humans; Neurotransmitter Uptake Inhibitors; Obsessive-Compulsive Disorder; Piperazines; Pyrazines; Pyrimidines; Serotonin

1992
Role of serotonin in obsessive-compulsive disorder.
    The British journal of psychiatry. Supplement, 1998, Issue:35

    Topics: Biogenic Monoamines; Fenfluramine; Humans; Neuropeptides; Obsessive-Compulsive Disorder; Piperazines; Pyrazines; Pyrimidines; Serotonin; Serotonin Syndrome; Synaptic Transmission; Tryptophan

1998

Trials

4 trial(s) available for ipsapirone and 1-(3-chlorophenyl)piperazine

ArticleYear
Decreased neuroendocrine responses to meta-chlorophenylpiperazine (m-CPP) but normal responses to ipsapirone in marathon runners.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1999, Volume: 20, Issue:2

    Topics: Adult; Anxiety; Behavior; Body Temperature; Double-Blind Method; Exercise Test; Female; Hormones; Humans; Male; Neurosecretory Systems; Physical Endurance; Piperazines; Pyrimidines; Receptor, Serotonin, 5-HT2C; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Running

1999
Serotonin hypothesis of winter depression: behavioral and neuroendocrine effects of the 5-HT(1A) receptor partial agonist ipsapirone in patients with seasonal affective disorder and healthy control subjects.
    Psychiatry research, 1999, Apr-19, Volume: 86, Issue:1

    Topics: Adrenocorticotropic Hormone; Adult; Depression; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Infusions, Intravenous; Male; Piperazines; Pituitary-Adrenal System; Prolactin; Pyrimidines; Receptors, Serotonin; Retrospective Studies; Seasonal Affective Disorder; Serotonin; Serotonin Receptor Agonists

1999
Effect of aerobic exercise on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine and to ipsapirone in untrained healthy subjects.
    Psychopharmacology, 2001, Volume: 155, Issue:3

    Topics: Adult; Behavior; Double-Blind Method; Down-Regulation; Exercise; Exercise Test; Female; Humans; Hydrocortisone; Jogging; Male; Neurosecretory Systems; Panic; Piperazines; Prolactin; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists

2001
Neuroendocrine response to meta-chlorophenylpiperazine and ipsapirone in relation to anxiety and aggression.
    Psychiatry research, 2002, Dec-15, Volume: 113, Issue:1-2

    Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Aggression; Anxiety Disorders; Cross-Over Studies; Double-Blind Method; Humans; Hydrocortisone; Middle Aged; Piperazines; Prolactin; Pyrimidines; Serotonin Receptor Agonists; Severity of Illness Index

2002

Other Studies

14 other study(ies) available for ipsapirone and 1-(3-chlorophenyl)piperazine

ArticleYear
Structure-activity relationship studies of central nervous system agents. 5. Effect of the hydrocarbon chain on the affinity of 4-substituted 1-(3-chlorophenyl)piperazines for 5-HT1A receptor site.
    Journal of medicinal chemistry, 1992, Jun-26, Volume: 35, Issue:13

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Brain; Central Nervous System; Hydrocarbons; Piperazines; Radioligand Assay; Rats; Receptors, Serotonin; Structure-Activity Relationship; Substrate Specificity; Tetrahydronaphthalenes

1992
Structure-affinity relationship studies on 5-HT1A receptor ligands. 1. Heterobicyclic phenylpiperazines with N4-alkyl substituents.
    Journal of medicinal chemistry, 1993, Sep-17, Volume: 36, Issue:19

    Topics: Animals; Binding Sites; Brain; Bridged Bicyclo Compounds; Piperazines; Rats; Receptors, Serotonin; Structure-Activity Relationship

1993
An antidepressant that extends lifespan in adult Caenorhabditis elegans.
    Nature, 2007, Nov-22, Volume: 450, Issue:7169

    Topics: Aging; Animals; Antidepressive Agents; Caenorhabditis elegans; Caloric Restriction; Humans; Longevity; Methiothepin; Mianserin; Octopamine; Receptors, Biogenic Amine; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Signal Transduction; Starvation

2007
Physical binding pocket induction for affinity prediction.
    Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19

    Topics: Binding Sites; Ligands; Models, Molecular; Neural Networks, Computer; Peptide Fragments; Protein Binding; Receptor, Serotonin, 5-HT1A

2009
5-HT1A and 5-HT1B agonists play a differential role on the respiratory frequency in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1990, Volume: 3, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Male; Naphthalenes; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reference Values; Respiration; Tetrahydronaphthalenes

1990
Inhibitory action of various 5-HT1B receptor agonists on rat masculine sexual behaviour.
    Pharmacology, biochemistry, and behavior, 1989, Volume: 34, Issue:4

    Topics: Animals; Indoles; Male; Piperazines; Psychomotor Performance; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Sexual Behavior, Animal

1989
Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands.
    European journal of pharmacology, 1988, Nov-08, Volume: 156, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Male; Methysergide; Naphthalenes; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Reflex, Startle; Tetrahydronaphthalenes

1988
Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists.
    Synapse (New York, N.Y.), 1987, Volume: 1, Issue:1

    Topics: Animals; Lysergic Acid Diethylamide; Male; Neurons; Piperazines; Pyrimidines; Raphe Nuclei; Rats; Rats, Inbred Strains; Serotonin; Serotonin Antagonists

1987
Functional and biochemical evidence for altered serotonergic function in the fawn-hooded rat strain.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:3

    Topics: Amphetamines; Animals; Body Temperature; Brain Chemistry; Growth Hormone; Hydroxyindoleacetic Acid; Male; Piperazines; Pyrimidines; Rats; Rats, Inbred Strains; Rats, Wistar; Serotonin; Serotonin Receptor Agonists; Species Specificity

1994
Serotonergic influences on male sexual behavior of rhesus monkeys: effects of serotonin agonists.
    Psychopharmacology, 1993, Volume: 111, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Copulation; Dose-Response Relationship, Drug; Ejaculation; Macaca mulatta; Male; Piperazines; Pyrimidines; Serotonin; Serotonin Receptor Agonists; Sexual Behavior, Animal

1993
Effects of selective 5-HT1 receptor agonists in water-deprived rats on salt intake in two-choice tests.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dose-Response Relationship, Drug; Drinking Behavior; Male; Piperazines; Pyrimidines; Rats; Receptors, Serotonin; Serotonin Receptor Agonists; Sodium Chloride; Taste; Water Deprivation

1993
The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.
    European journal of pharmacology, 1997, May-01, Volume: 325, Issue:2-3

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Buspirone; Columbidae; Discrimination Learning; Fluvoxamine; Indoles; Pindolol; Piperazines; Pyridines; Pyrimidines; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles

1997
Increased psychological responses and divergent neuroendocrine responses to m-CPP and ipsapirone in patients with panic disorder.
    International clinical psychopharmacology, 2000, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Female; Humans; Hydrocortisone; Hypothermia, Induced; Male; Panic Disorder; Piperazines; Pyrimidines; Receptors, Serotonin; Serotonin Receptor Agonists

2000
Effects of serotonin(1/2) receptor agonists on dark-phase food and water intake in rats.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 67, Issue:2

    Topics: Amphetamines; Animals; Darkness; Dose-Response Relationship, Drug; Drinking; Drinking Behavior; Eating; Feeding Behavior; Female; Indoles; Piperazines; Pyridines; Pyrimidines; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Thiophenes; Time Factors

2000