Compounds > iproniazid

iproniazid and moclobemide

iproniazid has been researched along with moclobemide in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.94)18.7374
1990's0 (0.00)18.2507
2000's6 (17.65)29.6817
2010's25 (73.53)24.3611
2020's2 (5.88)2.80

Authors

AuthorsStudies
Bruno-Blanch, L; Gálvez, J; García-Domenech, R1
Alcaro, S; Bolasco, A; Carradori, S; Chimenti, F; Chimenti, P; Cirilli, R; Ferretti, R; Granese, A; La Torre, F; Maccioni, E; Orallo, F; Ortuso, F; Secci, D; Yáñez, M1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Alcaro, S; Bizzarri, B; Bolasco, A; Carradori, S; Chimenti, F; Chimenti, P; Granese, A; Orallo, F; Ortuso, F; Secci, D; Yáñez, M1
Alcaro, S; Bolasco, A; Chimenti, F; Chimenti, P; Fioravanti, R; Orallo, F; Ortuso, F; Rossi, F; Secci, D; Yáñez, M1
Bizzarri, B; Bolasco, A; Carradori, S; Chimenti, F; Chimenti, P; Granese, A; Orallo, F; Secci, D; Yáñez, M1
Alcaro, S; Bolasco, A; Chimenti, F; Chimenti, P; Cirilli, R; Ferretti, R; Fioravanti, R; Orallo, F; Ortuso, F; Rossi, F; Sanna, ML; Secci, D; Yáñez, M1
Li, ZL; Liu, CH; Shi, L; Yang, Y; Zhu, HL; Zhu, ZW1
Alcaro, S; Borges, F; Gaspar, A; Milhazes, N; Orallo, F; Ortuso, F; Uriarte, E; Yáñez, M1
Alcaro, S; Bolasco, A; Cardia, MC; Carradori, S; Chimenti, F; Chimenti, P; Cirilli, R; Distinto, S; Ferretti, R; Granese, A; Kirchmair, J; Langer, T; Maccioni, E; Orallo, F; Ortuso, F; Secci, D; Yáñez, M1
Alcaro, S; Bolasco, A; Carradori, S; Chimenti, F; Chimenti, P; Granese, A; Orallo, F; Ortuso, F; Secci, D; Yáñez, M1
Alcaro, S; Cardia, MC; Costa, G; Distinto, S; Maccioni, E; Meleddu, R; Orallo, F; Sanna, ML; Secci, D; Vigo, S; Yanez, M1
Bolasco, A; Carradori, S; Chimenti, F; Chimenti, P; Cirilli, R; Gallinella, B; Granese, A; Orallo, F; Sanna, ML; Secci, D; Yáñez, M1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Alcaro, S; Bolasco, A; Fioravanti, R; Manna, F; Orallo, F; Ortuso, F; Rossi, F; Vitali, A; Yáñez, M1
Alcaro, S; Bolasco, A; Desideri, N; Fioravanti, R; Monaco, LP; Orallo, F; Ortuso, F; Yáñez, M1
Alcaro, S; Bolasco, A; Carradori, S; Chimenti, P; Ortuso, F; Secci, D; Yáñez, M1
Escobar, M; García-Mera, X; González-Díaz, H; Prado-Prado, F; Riera-Fernandez, P; Sobarzo-Sánchez, E; Yañez, M1
Alcaro, S; Bolasco, A; Cardia, MC; Distinto, S; Gaspari, M; Kirchmair, J; Maccioni, E; Markt, P; Meleddu, R; Ortuso, F; Sanna, ML; Secci, D; Wolber, G; Yáñez, M1
Abdalla, MM; Abdelhafez, OM; Ali, HI; Amin, KM; Batran, RZ1
Bolasco, A; Carradori, S; D'Ascenzio, M; Nescatelli, R; Secci, D; Yáñez, M1
Alcaro, S; Biava, M; Desideri, N; Fioravanti, R; Ortuso, F; Proietti Monaco, L; Yáñez, M2
Biava, M; Desideri, N; Fioravanti, R; Grammatica, L; Proietti Monaco, L; Yáñez, M1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Alcaro, S; Carradori, S; Cirilli, R; D'Ascenzio, M; De Monte, C; Mannina, L; Ortuso, F; Secci, D; Sobolev, AP; Yáñez, M1
Alcaro, S; Arridu, A; Bianco, G; Cirilli, R; Cossu, P; Cottiglia, F; Distinto, S; Faggi, C; Maccioni, E; Meleddu, R; Ortuso, F; Sanna, ML; Yanez, M1
Estrada, M; Herrera-Arozamena, C; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Rodríguez-Franco, MI; Romero, A; Viña, D1
de Andrés, L; Estrada Valencia, M; Herrera-Arozamena, C; Laurini, E; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Pricl, S; Ramos, E; Rodríguez-Franco, MI; Romero, A; Viña, D; Yáñez, M1
Cuadrado, A; Duarte, P; Estrada-Valencia, M; Fernández-Ginés, R; Franco-Gonzalez, JF; Gago, F; García-Yagüe, ÁJ; Herrera-Arozamena, C; Lagartera, L; León, R; López, MG; Michalska, P; Mills, A; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Rodríguez-Franco, MI1
Duarte, P; Estrada-Valencia, M; Fernández-Mendívil, C; Herrera-Arozamena, C; León, R; Lombardía, J; López, MG; López-Caballero, P; Michalska, P; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Rodríguez-Franco, MI; Sastre, ED; Senar, S1
Schläppi, B1
Maher, TJ; Ulus, IH; Wurtman, RJ1
Fisar, Z; Hroudová, J; Raboch, J1

Other Studies

34 other study(ies) available for iproniazid and moclobemide

ArticleYear
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship

2003
Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.
    Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16

    Topics: Chromatography, High Pressure Liquid; Cyclohexanones; Humans; Hydrazones; Inhibitory Concentration 50; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Stereoisomerism; Thermodynamics; Thiazoles; Thiosemicarbazones

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.
    Journal of medicinal chemistry, 2009, Apr-09, Volume: 52, Issue:7

    Topics: Coumarins; Crystallography, X-Ray; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship

2009
Chalcones: a valid scaffold for monoamine oxidases inhibitors.
    Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9

    Topics: Chalcones; Crystallography, X-Ray; Databases, Protein; Drug Design; Humans; Inhibitory Concentration 50; Isoenzymes; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors

2009
Synthesis and inhibitory activity against human monoamine oxidase of N1-thiocarbamoyl-3,5-di(hetero)aryl-4,5-dihydro-(1H)-pyrazole derivatives.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:2

    Topics: Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pyrazoles

2010
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.
    Bioorganic & medicinal chemistry, 2010, Volume: 18, Issue:3

    Topics: Flavanones; Flavones; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Stereoisomerism; Sulfhydryl Compounds

2010
Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.
    Bioorganic & medicinal chemistry, 2010, Feb-15, Volume: 18, Issue:4

    Topics: Animals; Brain; Magnetic Resonance Spectroscopy; Mitochondria; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Niacinamide; Rats; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship

2010
Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.
    Bioorganic & medicinal chemistry letters, 2010, May-01, Volume: 20, Issue:9

    Topics: Binding Sites; Chromones; Computer Simulation; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Isoforms

2010
Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.
    Bioorganic & medicinal chemistry, 2010, Jul-15, Volume: 18, Issue:14

    Topics: Chromatography, High Pressure Liquid; Humans; Hydrazones; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship; Thiazoles

2010
Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.
    Bioorganic & medicinal chemistry, 2010, Aug-01, Volume: 18, Issue:15

    Topics: Humans; Hydrazines; Hydrogen Peroxide; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship

2010
Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:10

    Topics: Animals; Cell Line; Humans; Insecta; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Pyrazoles; Recombinant Proteins; Structure-Activity Relationship; Thioamides

2010
Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.
    Journal of medicinal chemistry, 2010, Sep-09, Volume: 53, Issue:17

    Topics: Chromatography, High Pressure Liquid; Cyclohexanes; Humans; Hydrazines; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Triazoles

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.
    Bioorganic & medicinal chemistry letters, 2010, Nov-15, Volume: 20, Issue:22

    Topics: Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Prenylation; Pyrazoles; Structure-Activity Relationship

2010
Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.
    Journal of medicinal chemistry, 2011, Apr-14, Volume: 54, Issue:7

    Topics: Drug Discovery; Flavonoids; Humans; Inhibitory Concentration 50; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Conformation; Substrate Specificity

2011
Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:10

    Topics: Coumarins; Humans; Inhibitory Concentration 50; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship

2011
2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:12

    Topics: Antiprotozoal Agents; Aporphines; Databases, Factual; Humans; Ligands; Malaria, Falciparum; Markov Chains; Models, Biological; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Plasmodium falciparum; Protozoan Proteins; Quantitative Structure-Activity Relationship; Software; United States

2011
Synthesis and biological assessment of novel 2-thiazolylhydrazones and computational analysis of their recognition by monoamine oxidase B.
    European journal of medicinal chemistry, 2012, Volume: 48

    Topics: Binding Sites; Humans; Hydrazones; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Dynamics Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Parkinson Disease; Protein Conformation; Structure-Activity Relationship; Tandem Mass Spectrometry; Thiazoles

2012
Synthesis of new 7-oxycoumarin derivatives as potent and selective monoamine oxidase A inhibitors.
    Journal of medicinal chemistry, 2012, Dec-13, Volume: 55, Issue:23

    Topics: Coumarins; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Spectrophotometry, Infrared

2012
Recent advances in the development of selective human MAO-B inhibitors: (hetero)arylidene-(4-substituted-thiazol-2-yl)hydrazines.
    European journal of medicinal chemistry, 2012, Volume: 58

    Topics: Dose-Response Relationship, Drug; Humans; Hydrazines; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship

2012
1,5-Diphenylpenta-2,4-dien-1-ones as potent and selective monoamine oxidase-B inhibitors.
    European journal of medicinal chemistry, 2013, Volume: 59

    Topics: Cells, Cultured; Curcumin; Enzyme Activation; Humans; Inhibitory Concentration 50; Models, Molecular; Monoamine Oxidase Inhibitors; Quantum Theory; Structure-Activity Relationship

2013
Design, synthesis, and in vitro hMAO-B inhibitory evaluation of some 1-methyl-3,5-diphenyl-4,5-dihydro-1H-pyrazoles.
    Bioorganic & medicinal chemistry letters, 2013, Sep-15, Volume: 23, Issue:18

    Topics: Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Molecular Structure; Monoamine Oxidase; Pyrazoles; Structure-Activity Relationship

2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Identification of the stereochemical requirements in the 4-aryl-2-cycloalkylidenhydrazinylthiazole scaffold for the design of selective human monoamine oxidase B inhibitors.
    Bioorganic & medicinal chemistry, 2014, May-15, Volume: 22, Issue:10

    Topics: Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Design; Humans; Isoenzymes; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Thiazoles

2014
Drug design, synthesis, in vitro and in silico evaluation of selective monoaminoxidase B inhibitors based on 3-acetyl-2-dichlorophenyl-5-aryl-2,3-dihydro-1,3,4-oxadiazole chemical scaffold.
    European journal of medicinal chemistry, 2016, Jan-27, Volume: 108

    Topics: Computer Simulation; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Dynamics Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxadiazoles; Structure-Activity Relationship

2016
(E)-3-Heteroarylidenechroman-4-ones as potent and selective monoamine oxidase-B inhibitors.
    European journal of medicinal chemistry, 2016, Jul-19, Volume: 117

    Topics: Chromans; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Sensitivity and Specificity; Solvents; Structure-Activity Relationship

2016
New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.
    European journal of medicinal chemistry, 2016, Oct-04, Volume: 121

    Topics: Alzheimer Disease; Amines; Animals; Antioxidants; Cell Line, Tumor; Cholinesterases; Drug Design; Humans; Male; Mice; Molecular Targeted Therapy; Monoamine Oxidase; Neuroprotective Agents; Piperidines

2016
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.
    European journal of medicinal chemistry, 2018, Aug-05, Volume: 156

    Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Donepezil; Enzyme Inhibitors; Flavonoids; Humans; Indans; Lipoxygenase Inhibitors; Male; Mice, Inbred BALB C; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurogenesis; Neuroprotective Agents; Piperidines; Receptors, sigma; Sigma-1 Receptor

2018
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.
    European journal of medicinal chemistry, 2020, Mar-15, Volume: 190

    Topics: Animals; Antioxidants; Cell Line, Tumor; CHO Cells; Cricetulus; Humans; Indoles; Kelch-Like ECH-Associated Protein 1; Ligands; Lipoxygenase Inhibitors; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Monoamine Oxidase Inhibitors; Naphthalenes; Neurogenesis; NF-E2-Related Factor 2; Oxadiazoles; Protein Binding; Quinone Reductases; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2

2020
Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.
    Journal of medicinal chemistry, 2022, 03-24, Volume: 65, Issue:6

    Topics: Antioxidants; Ligands; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Oxidative Stress; Resveratrol

2022
The lack of hepatotoxicity in the rat with the new and reversible MAO-A inhibitor moclobemide in contrast to iproniazid.
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:5

    Topics: Animals; Benzamides; Body Weight; Chemical and Drug Induced Liver Injury; Iproniazid; Liver; Male; Moclobemide; Monoamine Oxidase Inhibitors; Rats; Rats, Inbred Strains; Time Factors

1985
Characterization of phentermine and related compounds as monoamine oxidase (MAO) inhibitors.
    Biochemical pharmacology, 2000, Jun-15, Volume: 59, Issue:12

    Topics: Animals; Antidepressive Agents; Brain; Dextroamphetamine; Dose-Response Relationship, Drug; Drug Interactions; Ephedrine; Iproniazid; Liver; Lung; Male; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phentermine; Rats; Rats, Sprague-Dawley

2000
Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.
    Neuro endocrinology letters, 2010, Volume: 31, Issue:5

    Topics: Affect; Amitriptyline; Animals; Antidepressive Agents; Antimanic Agents; Benzodiazepines; Cerebral Cortex; Citalopram; Clorgyline; Cocaine; Cyclohexanols; Desipramine; Fluoxetine; Imipramine; In Vitro Techniques; Iproniazid; Lithium; Mianserin; Mirtazapine; Mitochondria; Moclobemide; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morpholines; Olanzapine; Pargyline; Reboxetine; Swine; Thiazepines; Valproic Acid; Venlafaxine Hydrochloride

2010