iothalamate-meglumine and methylglucamine-metrizoate

Meglumine iothalamate (Conray Meglumin), sodium-calcium-meglumine metrizoate (Isopaque Cerebral) and dimeglumine iocarmate (Dimerex), each containing about 280 mg I/ml, were compared in two series of double contrast knee arthrography, 190 and 184 patients each. With Dimerex the mixing of the contrast medium with the synovial fluid was slower than with Conray Meglumin, and a good or fair image quality, as evaluated subjectively, lasted longer. No difference was observed between Isopaque Cerebral and Conray Meglumin, regardless of dosage.

Topics: Adolescent; Adult; Female; Humans; Iodobenzoates; Iothalamate Meglumine; Iothalamic Acid; Knee Joint; Male; Meglumine; Metrizoic Acid; Middle Aged; Radiography; Sorbitol

Statistically significant eosinophilia was noted in the peripheral blood of a group of 108 patients 48 h after the administration of iodinated radiographic contrast medium (RCM). The duration of eosinophilia was approximately 6 days. Eosinophilia had no accompanying clinical symptoms except for two cases where urticaria appeared. The incidence of eosinophilia was irrespective of dosage or type of RCM. Possible mechanisms responsible for eosinophilia have been considered. Since eosinophilias of other aetiologies are common, it is of practical importance to distinguish these from RCM-induced eosinophilias.

Topics: Contrast Media; Eosinophilia; Eosinophils; Humans; Iothalamate Meglumine; Ioxaglic Acid; Leukocyte Count; Metrizoic Acid; Time Factors; Triiodobenzoic Acids