iothalamate-meglumine and iocarmate-meglumine

Topics: Contrast Media; Drug Evaluation; Drug Tolerance; Humans; Iothalamate Meglumine; Iothalamic Acid; Meglumine; Metrizamide; Organic Chemicals; Radiography

The adverse effects following lumbar myelography and ventriculography with meglumine iothalamate (Conray Meglumin), meglumine iocarmate (Dimer-X, Bis-Conray) and metrizamide (Amipaque), and after thoracic and cervical myelography and cisternography with metrizamide are reviewed. In addition to the published material information given to Nyegaard & Co. from several hospitals participating in clinical trials with metrizamide is also reported. The frequency of minor adverse effects (headache, nausea, vomiting) seems to be about the same with all the three water-soluble contrast media. Convulsions, either localized to the lower part of the body or generalized, may be a problem with meglumine iothalamate and meglumine iocarmate, while the epileptogenic effect is markedly lower with metrizamide. With a technique directed towards preventing contrast medium of high concentration from passing intracranially, the frequency of serious adverse effects may be kept at a very low level. Late adverse effects (adhesive arachnoiditis) occurring after all other water-soluble contrast media are a very minor problem after metrizamide. Serious complications have not been recorded following ventriculography and cisternography with metrizamide. Metrizamide is considered to be the water-soluble contrast medium best suited for use in the subarachnoid space and cerebral ventricles.

Topics: Cerebral Ventriculography; Contrast Media; Humans; Iothalamate Meglumine; Iothalamic Acid; Meglumine; Metrizamide; Myelography

Meglumine iothalamate (Conray Meglumin), sodium-calcium-meglumine metrizoate (Isopaque Cerebral) and dimeglumine iocarmate (Dimerex), each containing about 280 mg I/ml, were compared in two series of double contrast knee arthrography, 190 and 184 patients each. With Dimerex the mixing of the contrast medium with the synovial fluid was slower than with Conray Meglumin, and a good or fair image quality, as evaluated subjectively, lasted longer. No difference was observed between Isopaque Cerebral and Conray Meglumin, regardless of dosage.

Topics: Adolescent; Adult; Female; Humans; Iodobenzoates; Iothalamate Meglumine; Iothalamic Acid; Knee Joint; Male; Meglumine; Metrizoic Acid; Middle Aged; Radiography; Sorbitol