iodine and carbostyril

iodine has been researched along with carbostyril in 62 studies

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (8.06)	29.6817
2010's	48 (77.42)	24.3611
2020's	9 (14.52)	2.80

Authors

Authors	Studies
Tohma, H	1
Flynn, BL; Hessian, KO	1
Bauer, J; Milić, D; Modrić, M	1
Manetsch, R; Monastyrskyi, A; Namelikonda, NK	1
Deb, A; Dutta, U; Lupton, DW; Maiti, D	1
Fujita, N; Fukuda, M; Ishida, H; Kubo, E; Miyashita, H; Sasaki, H; Shibata, N; Shibata, S; Tanimura, N	1
Huang, B; Li, H; Lin, JP; Long, YQ; Song, LR; Wang, SF	1
Accurso, FJ; Aitken, ML; Ashlock, MA; Boyle, MP; Campbell, PW; Clancy, JP; Donaldson, SH; Dong, Q; Dunitz, JM; Durie, PR; Freedman, SD; Hornick, DB; Konstan, MW; Mayer-Hamblett, N; Moss, RB; Olson, ER; Ordoñez, CL; Pilewski, JM; Ramsey, BW; Rose, LM; Rowe, SM; Rubenstein, RC; Sagel, SD; Stone, AJ; Uluer, AZ; Zha, J	1
Borowitz, DS; Flume, PA; Geller, DE; Li, H; Liou, TG; Ordoñez, CL; Yen, K	1
Chowdhury, BA; Durmowicz, AG; Rosebraugh, CJ; Witzmann, KA	2
Sermet-Gaudelus, I	1
Elborn, JS	1
Mueller, P; Rodman, D; Schmelz, A; Seliger, VI; Van Goor, F	1
Heltshe, SL; Mayer-Hamblett, N; Rowe, SM	2
Harrison, MJ; Murphy, DM; Plant, BJ	1
McGarry, ME; Nielson, DW	1
Barry, PJ; Horsley, AR; Jones, AM; Webb, AK	1
Grasemann, H; Ratjen, F; Solomon, M	1
Char, JE; Cho, HJ; Davies, Z; Dunn, C; Frisbee, E; Jeong, JH; Milla, C; Moss, RB; Park, IH; Thomas, EA; Wine, JJ; Wolfe, MH	1
Accurso, FJ; Ashlock, MA; Campbell, PW; Clancy, JP; Dong, Q; Heltshe, SL; Hoch, HE; Konstan, MW; Ordonez, CL; Ramsey, BW; Rowe, SM; Stone, AJ; Van Goor, F; Zha, J	1
Borowitz, D; Donaldson, SH; Gelfond, D; Gonska, T; Heltshe, SL; Joseloff, E; Khan, U; Mayer-Hamblett, N; Ramsey, BW; Rowe, SM; Sagel, SD; Van Dalfsen, JM	1
Bell, SC; Boyle, MP; Huang, X; Konstan, MW; McColley, SA; Patel, NR; Rietschel, E; Rodman, D; Rowe, SM; Waltz, D	1
Ahrens, R; Elborn, JS; Johnson, C; Konstan, MW; Munck, A; Plant, BJ; Rodriguez, S	1
Cooke, J; Cunningham, S; Davies, JC; Green, Y; Harris, WT; Lapey, A; Regelmann, WE; Robertson, S; Rosenfeld, M; Sawicki, GS; Southern, KW	1
Bilton, D; Davies, JC; De Boeck, K; Le Camus, C; Milenković, D; Vermeulen, F	1
Bassinet, L; Cohen, M; Escabasse, V; Friedman, H; Hatton, A; Le Bourgeois, M; Livnat, G; Lucidi, V; Mesbahi, M; Nguyen-Khoa, T; Sermet-Gaudelus, I; Shteinberg, M; Wilschanski, M	1
Beusmans, J; Fidler, MC; Panorchan, P; Van Goor, F	1
Finkbeiner, WE; Illek, B; Ly, NP; McGarry, ME; Moreno, C; Nielson, DW; Olshansky, S; Zlock, L	1
Char, JE; Davies, Z; Dunn, C; Milla, C; Moss, RB; Wine, JJ	1
Casavola, V; Castellani, S; Conese, M; D'Oria, S; Favia, M; Gallo, C; Guerra, L; Leonetti, G; Manca, A; Mariggiò, MA; Montemurro, P; Polizzi, AM; Santostasi, T	1
Ashkenazi, M; Bar Aluma, BE; Bentur, L; Bezalel, Y; Blau, H; Cohen-Cymberknoh, M; Dagan, A; Efrati, O; Kerem, E; Lavie, M; Levine, H; Livnat, G; Sarouk, I; Shteinberg, M; Tsabari, R; Vilozni, D	1
Chowdhury, BA; Durmowicz, AG; Lim, R; Rogers, H; Rosebraugh, CJ	1
Abou Alaiwa, MH; Carter, S; Grogan, B; Launspach, JL; McKone, EF; Singh, PK; Stoltz, DA; Welsh, MJ; Zabner, J	1
Amaral, MD; Balla, G; Balogh, I; Bell, SC; Bene, Z; Fejes, Z; Heltshe, SL; Joseloff, E; Kappelmayer, J; Macek, M; McCarthy, Y; Nagy, A; Nagy, B; Plant, BJ; Reid, D; Ronan, NJ; Smith, D	1
Burr, L; Daines, C; Keating, D; Mall, MA; Marigowda, G; McKee, CM; McKone, EF; Moskowitz, SM; Ramsey, BW; Robertson, S; Rowe, SM; Sass, LA; Savage, J; Simard, C; Taylor-Cousar, JL; Tullis, E; Van Goor, F; Waltz, D; Xuan, F; Young, T	1
Brown, C; Davies, JC; Horsley, A; Mall, MA; McKee, CM; McKone, EF; Moskowitz, SM; Plant, BJ; Prais, D; Ramsey, BW; Robertson, S; Rowe, SM; Shilling, RA; Simard, C; Taylor-Cousar, JL; Tullis, E; Uluer, A; Van Goor, F; Waltz, D; Xuan, F; Young, T	1
Bratcher, PE; Hunt, KC; Pickard, K; Taylor-Cousar, JL	1
Dunn, C; Farahmand, M; Horii, RI; Kim, J; Milla, CE; Moss, RB; Thomas, EAC; Wine, JJ	1
Achimastos, D; Baatallah, N; Bailly, C; Chedevergne, F; Edelman, A; Flament, T; Girodon, E; Hatton, A; Hinzpeter, A; Kyrilli, S; Le Bourgeois, M; Masson, A; Nguyen-Khoa, T; Schneider-Futschik, EK; Sermet-Gaudelus, I	1
Amaral, MD; Bertuzzo, CS; Kmit, A; Leite, GS; Marson, FAL; Pereira, SV; Ribeiro, AF; Ribeiro, JD; Servidoni, MF; Vinagre, AM	1
Course, CW; Hanks, R	1
Chilvers, M; Cooke, J; Cunningham, S; Davies, JC; Harris, WT; Higgins, M; Lapey, A; Regelmann, WE; Rosenfeld, M; Sawicki, GS; Southern, KW; Tian, S	1
Barry, PJ; Bell, SC; Bellaire, S; Conrath, K; De Boeck, K; de Kock, H; Drevinek, P; Elborn, JS; Geller, DE; Kanters, D; Minić, P; Muller, K; Plant, BJ; Van Braeckel, E; Van de Steen, O; van der Ent, K; Verhulst, S	1
Allamassey, L; Conrath, K; Davies, JC; de Kock, H; Derichs, N; Drevinek, P; Kanters, D; McKone, EF; Namour, F; Van de Steen, O; van Koningsbruggen-Rietschel, S	1
Braggion, C; Carnovale, V; Castellani, C; Cimino, G; Colangelo, C; Ferrara, N; Francalanci, M; Iacotucci, P; Leonetti, G; Lucidi, V; Manca, A; Salvatore, D; Vitullo, P	1
Ahluwalia, N; Chilvers, M; Chmiel, J; Flume, P; Harris, RS; Haseltine, E; Li, C; McNamara, J; Owen, CA; Sawicki, G; Solomon, M; Stiles, D; Walker, S; Zhou, H	1
Bellaire, S; Bwirire, D; Conrath, K; Corveleyn, S; Fischer, R; Gleiber, W; Hector, A; Kempa, A; Muller, K; Pano, A; Santermans, E; Schwarz, C; Sutharsan, S; Van de Steen, O; van Koningsbruggen-Rietschel, S; Van Osselaer, N	1
Harris, JK; Heltshe, SL; Robertson, CE; Rowe, SM; Sagel, SD; Stevens, MJ; Wagner, BD; Zemanick, ET	1
Ahluwalia, N; Downey, DG; Heijerman, HGM; Mall, MA; Marigowda, G; McCoy, KS; McKee, CM; McKone, EF; Moskowitz, SM; Ramsey, BW; Rowe, SM; Simard, C; Sosnay, PR; Taylor-Cousar, JL; Tullis, E; Van Braeckel, E; Waltz, D; Welter, JJ; Xuan, F; Zhang, Y	1
Dřevínek, P; Jain, R; Lands, LC; Mall, MA; Marigowda, G; McKee, CM; McKone, EF; Middleton, PG; Moskowitz, SM; Nair, N; Polineni, D; Ramsey, BW; Rowe, SM; Savage, J; Simard, C; Taylor-Cousar, JL; Tian, S; Tullis, E; Vermeulen, F; Waltz, D; Xuan, F	1
Guimbellot, JS; Heltshe, SL; Jain, M; Jovanovic, B; Rowe, SM; Sagel, SD; Secunda, KE	1
Aalbers, BL; Arets, HGM; Bronsveld, I; de Kiviet, AC; de Winter-de Groot, KM; Heijerman, HGM; Hofland, RW; Kruijswijk, MA; Michel, S; Schotman, S; van der Ent, CK; van Oirschot-van de Ven, MMM	1
Beekman, JM; Graeber, SY; Hirtz, S; Kruisselbrink, E; Mall, MA; van der Ent, CK; van Mourik, P; Vonk, AM	1
Clancy, JP; Konstan, MW; Mayer-Hamblett, N; Odem-Davis, K; Rowe, SM; Skalland, M; VanDevanter, DR; Zemanick, ET	1
Bertini, M; Casiraghi, A; Cipolli, M; Fedrigo, A; Iansa, P; Kleinfelder, K; Melotti, P; Minghetti, P; Pintani, E; Sorio, C; Treggiari, D; Tridello, G	1
Dittrich, AM; Hansen, G; Junge, S; Nietert, M; Pallenberg, ST; Ringshausen, FC; Sauer-Heilborn, A; Tümmler, B	1
Anderson, CE; Bosscher, MA; Ellsworth, BA; Lanni, EL; Ooms, BD; Shandro, CA	1
Fan, G; Fei, Y; Lu, G; Wu, Y	1
Berrino, R; Cacchi, S; Fabrizi, G; Goggiamani, A	1
Bugeja, LA; Cai, Z; Hawley, BR; Li, H; Liu, J; Loizidou, A; Sheppard, DN; Toye, AM; Wang, Y; Warner, R	1

Reviews

3 review(s) available for iodine and carbostyril

Article	Year
[Development of novel oxidation reactions using hypervalent iodine reagents and their application to total synthesis of biologically active natural products]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2000, Volume: 120, Issue:7 Topics: Alkaloids; Antineoplastic Agents; Cyclization; Indicators and Reagents; Iodine; Oxidation-Reduction; Phenyl Ethers; Pyrroles; Quinolones	2000
Ivacaftor treatment in patients with cystic fibrosis and the G551D-CFTR mutation. European respiratory review : an official journal of the European Respiratory Society, 2013, Mar-01, Volume: 22, Issue:127 Topics: Adolescent; Adult; Aminophenols; Child; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Genetic Predisposition to Disease; Humans; Lung; Molecular Targeted Therapy; Mutation; Patient Selection; Phenotype; Precision Medicine; Quinolones; Respiratory System Agents; Sweat; Time Factors; Treatment Outcome; Young Adult	2013
Newborn screening for cystic fibrosis: Is there benefit for everyone? Paediatric respiratory reviews, 2019, Volume: 31 Topics: Aminophenols; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; False Positive Reactions; Health Policy; Humans; Infant, Newborn; Mutation; Neonatal Screening; Penetrance; Phenotype; Quinolones; Risk Assessment; Sweat	2019

Trials

19 trial(s) available for iodine and carbostyril

Article	Year
Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation. The New England journal of medicine, 2010, Nov-18, Volume: 363, Issue:21 Topics: Adult; Aminophenols; Chlorides; Cross-Over Studies; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Ion Channels; Male; Membrane Potentials; Middle Aged; Mutation; Nasal Mucosa; Quinolones; Sweat; Young Adult	2010
Ivacaftor in subjects with cystic fibrosis who are homozygous for the F508del-CFTR mutation. Chest, 2012, Volume: 142, Issue:3 Topics: Adolescent; Adult; Alleles; Aminophenols; Biomarkers; Child; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Double-Blind Method; Female; Homozygote; Humans; Male; Middle Aged; Mutation; Pharmacogenetics; Quinolones; Sweat; Treatment Outcome; Young Adult	2012
Sweat chloride as a biomarker of CFTR activity: proof of concept and ivacaftor clinical trial data. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2014, Volume: 13, Issue:2 Topics: Adult; Aminophenols; Biomarkers; Child; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Double-Blind Method; Drug Monitoring; Female; Humans; Male; Mutation; Nasal Mucosa; Quinolones; Reproducibility of Results; Respiratory System Agents; Specimen Handling; Sweat; Treatment Outcome	2014
A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial. The Lancet. Respiratory medicine, 2014, Volume: 2, Issue:7 Topics: Adolescent; Adult; Aminophenols; Aminopyridines; Base Sequence; Benzodioxoles; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Double-Blind Method; Drug Therapy, Combination; Female; Forced Expiratory Volume; Heterozygote; Homozygote; Humans; Male; Quinolones; Sequence Deletion; Sweat; Young Adult	2014
Efficacy response in CF patients treated with ivacaftor: post-hoc analysis. Pediatric pulmonology, 2015, Volume: 50, Issue:5 Topics: Adolescent; Adult; Aminophenols; Child; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Progression; Female; Forced Expiratory Volume; Humans; Male; Mutation; Numbers Needed To Treat; Quinolones; Respiratory Function Tests; Surveys and Questionnaires; Sweat; Weight Gain; Young Adult	2015
Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2-5 years with cystic fibrosis and a CFTR gating mutation (KIWI): an open-label, single-arm study. The Lancet. Respiratory medicine, 2016, Volume: 4, Issue:2 Topics: Aminophenols; Child, Preschool; Chloride Channel Agonists; Chlorides; Cough; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Forced Expiratory Volume; Genotype; Humans; Male; Mutation; Quinolones; Sweat	2016
Variability of sweat chloride concentration in subjects with cystic fibrosis and G551D mutations. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2017, Volume: 16, Issue:1 Topics: Adolescent; Adult; Aminophenols; Biological Variation, Population; Biomarkers; Child; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; Male; Middle Aged; Mutation; Quinolones; Retrospective Studies; Sweat	2017
In vivo and in vitro ivacaftor response in cystic fibrosis patients with residual CFTR function: N-of-1 studies. Pediatric pulmonology, 2017, Volume: 52, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Aminophenols; Chloride Channel Agonists; Chlorides; Cross-Over Studies; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; Male; Middle Aged; Quinolones; Sweat; Treatment Outcome; Young Adult	2017
CFTR-dependent chloride efflux in cystic fibrosis mononuclear cells is increased by ivacaftor therapy. Pediatric pulmonology, 2017, Volume: 52, Issue:7 Topics: Adolescent; Adult; Aminophenols; C-Reactive Protein; Child; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; Leukocytes, Mononuclear; Male; Mutation; Neutrophils; Quinolones; Respiratory Function Tests; Sweat; Young Adult	2017
VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. The New England journal of medicine, 2018, 10-25, Volume: 379, Issue:17 Topics: Adolescent; Adult; Alleles; Aminophenols; Benzodioxoles; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Double-Blind Method; Drug Combinations; Female; Forced Expiratory Volume; Genotype; Humans; Indoles; Male; Mutation; Pyrazoles; Pyridines; Pyrrolidines; Quinolones; Sweat; Young Adult	2018
VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles. The New England journal of medicine, 2018, 10-25, Volume: 379, Issue:17 Topics: Adolescent; Adult; Alleles; Aminophenols; Benzodioxoles; Cells, Cultured; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Double-Blind Method; Drug Combinations; Female; Forced Expiratory Volume; Genotype; Humans; Indoles; Male; Mutation; Pyrazoles; Pyrrolidines; Quinolones; Sweat; Young Adult	2018
Sweat rate analysis of ivacaftor potentiation of CFTR in non-CF adults. Scientific reports, 2018, 11-02, Volume: 8, Issue:1 Topics: Adult; Aminophenols; Chloride Channel Agonists; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Female; Humans; Male; Quinolones; Sweat; Sweat Glands; Sweating	2018
An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2-5 years (KLIMB). Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019, Volume: 18, Issue:6 Topics: Aminophenols; Body Mass Index; Child, Preschool; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; Ion Channel Gating; Liver Function Tests; Male; Pancreas; Quinolones; Sodium Chloride; Sweat; Transaminases; Treatment Outcome; Weight Gain	2019
CFTR activity is enhanced by the novel corrector GLPG2222, given with and without ivacaftor in two randomized trials. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019, Volume: 18, Issue:5 Topics: Administration, Oral; Adult; Aminophenols; Benzoates; Benzopyrans; Biological Availability; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Double-Blind Method; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Male; Mutation; Quinolones; Respiratory Function Tests; Sweat; Treatment Outcome	2019
GLPG1837, a CFTR potentiator, in p.Gly551Asp (G551D)-CF patients: An open-label, single-arm, phase 2a study (SAPHIRA1). Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019, Volume: 18, Issue:5 Topics: Adult; Aminophenols; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Drug Monitoring; Drug Substitution; Female; Humans; Male; Pyrans; Pyrazoles; Quinolones; Respiratory Function Tests; Sweat; Treatment Outcome; Withholding Treatment	2019
A phase 3 study of tezacaftor in combination with ivacaftor in children aged 6 through 11 years with cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019, Volume: 18, Issue:5 Topics: Aminophenols; Benzodioxoles; Biological Availability; Child; Child, Preschool; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Drug Monitoring; Drug Therapy, Combination; Female; Humans; Indoles; Male; Mutation; Quinolones; Respiratory Function Tests; Sweat; Treatment Outcome	2019
GLPG2737 in lumacaftor/ivacaftor-treated CF subjects homozygous for the F508del mutation: A randomized phase 2A trial (PELICAN). Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2020, Volume: 19, Issue:2 Topics: Adult; Aminophenols; Aminopyridines; Benzodioxoles; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Combinations; Female; Homozygote; Humans; Male; Mutation; Quinolones; Respiratory Function Tests; Sweat; Treatment Outcome	2020
Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial. Lancet (London, England), 2019, 11-23, Volume: 394, Issue:10212 Topics: Adolescent; Aminophenols; Benzodioxoles; Child; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indoles; Male; Pyrazoles; Pyridines; Pyrrolidines; Quinolones; Sweat	2019
Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele. The New England journal of medicine, 2019, 11-07, Volume: 381, Issue:19 Topics: Adolescent; Adult; Aminophenols; Benzodioxoles; Child; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Double-Blind Method; Drug Combinations; Female; Forced Expiratory Volume; Genotype; Humans; Indoles; Male; Mutation; Pyrazoles; Pyridines; Pyrrolidines; Quinolones; Sweat; Young Adult	2019

Other Studies

40 other study(ies) available for iodine and carbostyril

Article	Year
Selective endo and exo iodocyclizations in the synthesis of quinolines and indoles. Organic letters, 2006, Jan-19, Volume: 8, Issue:2 Topics: Catalysis; Cyclization; Indoles; Iodine; Molecular Structure; Quinolines; Quinolones; Stereoisomerism	2006
Three quinolone compounds featuring O...I halogen bonding. Acta crystallographica. Section C, Crystal structure communications, 2009, Volume: 65, Issue:Pt 10 Topics: Crystallography, X-Ray; Cyclopropanes; Halogens; Iodine; Models, Molecular; Quinolines; Quinolones	2009
Metal-free arylation of ethyl acetoacetate with hypervalent diaryliodonium salts: an immediate access to diverse 3-aryl-4(1H)-quinolones. The Journal of organic chemistry, 2015, Mar-06, Volume: 80, Issue:5 Topics: Acetoacetates; Antimalarials; Iodine; Metals; Molecular Structure; Onium Compounds; Quinolines; Quinolones	2015
The regioselective iodination of quinolines, quinolones, pyridones, pyridines and uracil. Chemical communications (Cambridge, England), 2015, Dec-28, Volume: 51, Issue:100 Topics: Halogenation; Iodine; Isomerism; Models, Chemical; Pyridones; Quinolones; Uracil	2015
Polyvinyl alcohol-iodine induced corneal epithelial injury in vivo and its protection by topical rebamipide treatment. PloS one, 2018, Volume: 13, Issue:11 Topics: Administration, Ophthalmic; Alanine; Animals; Antioxidants; Corneal Injuries; Epithelium, Corneal; Iodine; Male; Polyvinyl Alcohol; Protective Agents; Quinolones; Rabbits	2018
Metal-free hypervalent iodine-promoted tandem carbonyl migration and unactivated C(Ph)-C(Alkyl) bond cleavage for quinolone scaffold synthesis. Chemical communications (Cambridge, England), 2022, Jul-26, Volume: 58, Issue:60 Topics: Cyclization; Iodides; Iodine; Metals; Quinolones	2022
Change in sweat chloride as a clinical end point in cystic fibrosis clinical trials: the ivacaftor experience. Chest, 2013, Volume: 143, Issue:1 Topics: Aminophenols; Chlorides; Clinical Trials as Topic; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Forced Expiratory Volume; Humans; Outcome Assessment, Health Care; Quinolones; Sweat; Treatment Outcome	2013
The impact of personalised therapies on respiratory medicine. European respiratory review : an official journal of the European Respiratory Society, 2013, Mar-01, Volume: 22, Issue:127 Topics: Aminophenols; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Genetic Predisposition to Disease; Humans; Lung; Molecular Targeted Therapy; Mutation; Patient Selection; Phenotype; Precision Medicine; Pulmonary Medicine; Quinolones; Respiratory System Agents; Sweat; Treatment Outcome	2013
The predictive potential of the sweat chloride test in cystic fibrosis patients with the G551D mutation. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2013, Volume: 12, Issue:6 Topics: Administration, Oral; Adolescent; Aminophenols; Child; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Forced Expiratory Volume; Humans; Male; Mutation; Quinolones; Sensitivity and Specificity; Sweat; Weight Gain	2013
Evaluating the predictive ability of sweat chloride. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2014, Volume: 13, Issue:1 Topics: Aminophenols; Chlorides; Cystic Fibrosis; Female; Humans; Male; Quinolones; Sweat	2014
Ivacaftor in a G551D homozygote with cystic fibrosis. The New England journal of medicine, 2013, Sep-26, Volume: 369, Issue:13 Topics: Adolescent; Aminophenols; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Forced Expiratory Volume; Homozygote; Humans; Mutation; Quinolones; Sweat	2013
Normalization of sweat chloride concentration and clinical improvement with ivacaftor in a patient with cystic fibrosis with mutation S549N. Chest, 2013, Volume: 144, Issue:4 Topics: Aminophenols; Child; Chlorides; Cystic Fibrosis; Female; Humans; Mutation; Quinolones; Sweat	2013
Response. Chest, 2013, Volume: 144, Issue:4 Topics: Aminophenols; Chlorides; Cystic Fibrosis; Humans; Outcome Assessment, Health Care; Quinolones; Sweat	2013
Understanding the relationship between sweat chloride and lung function in cystic fibrosis. Chest, 2013, Volume: 144, Issue:4 Topics: Aminophenols; Chlorides; Cystic Fibrosis; Humans; Outcome Assessment, Health Care; Quinolones; Sweat	2013
Sweat chloride is not a useful marker of clinical response to Ivacaftor. Thorax, 2014, Volume: 69, Issue:6 Topics: Aminophenols; Biomarkers; Body Height; Body Weight; Chlorides; Cohort Studies; Cystic Fibrosis; Forced Expiratory Flow Rates; Humans; Lung; Prospective Studies; Quinolones; Spirometry; Sweat	2014
Aquagenic wrinkling of the palms in a patient with cystic fibrosis. The New England journal of medicine, 2013, Dec-12, Volume: 369, Issue:24 Topics: Aminophenols; Child; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Genotype; Hand; Humans; Male; Quinolones; Skin Aging; Sweat; Water	2013
A little CFTR goes a long way: CFTR-dependent sweat secretion from G551D and R117H-5T cystic fibrosis subjects taking ivacaftor. PloS one, 2014, Volume: 9, Issue:2 Topics: Amino Acid Substitution; Aminophenols; Case-Control Studies; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; Male; Quinolones; Sweat; Sweat Glands	2014
Clinical mechanism of the cystic fibrosis transmembrane conductance regulator potentiator ivacaftor in G551D-mediated cystic fibrosis. American journal of respiratory and critical care medicine, 2014, Jul-15, Volume: 190, Issue:2 Topics: Adolescent; Adult; Aminophenols; Biomarkers; Child; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Follow-Up Studies; Forced Expiratory Volume; Genetic Markers; Hospitalization; Humans; Hydrogen-Ion Concentration; Intestine, Small; Lung; Male; Microbiota; Mucociliary Clearance; Mutation; Pseudomonas aeruginosa; Pseudomonas Infections; Quinolones; Respiratory System Agents; Sputum; Sweat; Treatment Outcome; Young Adult	2014
Changes of CFTR functional measurements and clinical improvements in cystic fibrosis patients with non p.Gly551Asp gating mutations treated with ivacaftor. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2017, Volume: 16, Issue:1 Topics: Adolescent; Adult; Aminophenols; Child; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Humans; Male; Membrane Potentials; Middle Aged; Mutation; Nasal Mucosa; Outcome Assessment, Health Care; Quinolones; Sweat; Treatment Outcome	2017
Correlation of sweat chloride and percent predicted FEV Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2017, Volume: 16, Issue:1 Topics: Aminophenols; Biomarkers; Chloride Channel Agonists; Chlorides; Clinical Trials as Topic; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Forced Expiratory Volume; Humans; Mutation; Predictive Value of Tests; Quinolones; Sweat; Treatment Outcome	2017
The magnitude of ivacaftor effects on fluid secretion via R117H-CFTR channels: Human in vivo measurements. PloS one, 2017, Volume: 12, Issue:4 Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Aminophenols; Analysis of Variance; Chloride Channel Agonists; Cystic Fibrosis Transmembrane Conductance Regulator; Exons; Female; Gene Deletion; Humans; Injections, Intradermal; Ion Channel Gating; Male; Methacholine Chloride; Muscarinic Agonists; Mutation; Quinolones; Sweat; Sweating	2017
Ivacaftor for the p.Ser549Arg (S549R) gating mutation - The Israeli experience. Respiratory medicine, 2017, Volume: 131 Topics: Adolescent; Adult; Aminophenols; Blood Glucose; Body Mass Index; Child; Chloride Channel Agonists; Cohort Studies; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Forced Expiratory Volume; Glucose Tolerance Test; Humans; Israel; Male; Mutation; Quinolones; Retrospective Studies; Sweat; Treatment Outcome; Vital Capacity; Young Adult	2017
The U.S. Food and Drug Administration's Experience with Ivacaftor in Cystic Fibrosis. Establishing Efficacy Using In Vitro Data in Lieu of a Clinical Trial. Annals of the American Thoracic Society, 2018, Volume: 15, Issue:1 Topics: Aminophenols; Chloride Channel Agonists; Clinical Trials as Topic; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Approval; Drug Development; Humans; Mutation; Quinolones; Sweat; United States; United States Food and Drug Administration	2018
Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis. JCI insight, 2018, 08-09, Volume: 3, Issue:15 Topics: Adult; Aminophenols; Animals; Bicarbonates; Biological Transport, Active; Bronchoalveolar Lavage Fluid; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Female; Humans; Hydrogen-Ion Concentration; Infant; Infant, Newborn; Ion Transport; Longitudinal Studies; Lung; Male; Middle Aged; Mutation; Quinolones; Respiratory Mucosa; Sweat; Young Adult	2018
Human epididymis protein 4 (HE4) levels inversely correlate with lung function improvement (delta FEV Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019, Volume: 18, Issue:2 Topics: Adult; Aminophenols; Biomarkers; Body Mass Index; Child; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Monitoring; Female; Forced Expiratory Volume; Humans; Male; Mutation; Quinolones; Respiratory Function Tests; Retrospective Studies; Sweat; WAP Four-Disulfide Core Domain Protein 2	2019
Positive clinical response to ivacaftor treatment in an individual with the CFTR genotype F508del/V456A. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019, Volume: 18, Issue:2 Topics: Adult; Aminophenols; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Monitoring; Humans; Male; Mutation; Quinolones; Respiratory Function Tests; Sweat; Treatment Outcome	2019
Predictive factors for lumacaftor/ivacaftor clinical response. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2019, Volume: 18, Issue:3 Topics: Aminophenols; Aminopyridines; Benzodioxoles; Biomarkers, Pharmacological; Child; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Combinations; Drug Monitoring; Female; Humans; Male; Mutation; Pharmacogenomic Testing; Quinolones; Respiratory Function Tests; Sweat; Treatment Outcome; Young Adult	2019
Extent of rescue of F508del-CFTR function by VX-809 and VX-770 in human nasal epithelial cells correlates with SNP rs7512462 in SLC26A9 gene in F508del/F508del Cystic Fibrosis patients. Biochimica et biophysica acta. Molecular basis of disease, 2019, 06-01, Volume: 1865, Issue:6 Topics: Alleles; Aminophenols; Aminopyridines; Antiporters; Base Sequence; Benzodioxoles; Body Mass Index; Case-Control Studies; Cellular Reprogramming; Chloride Channel Agonists; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Diffusion Chambers, Culture; Epithelial Cells; Gene Expression; Genotype; Humans; Models, Biological; Nasal Mucosa; Polymorphism, Single Nucleotide; Primary Cell Culture; Quinolones; Sequence Deletion; Sulfate Transporters; Sweat	2019
Effectivenesss of ivacaftor in severe cystic fibrosis patients and non-G551D gating mutations. Pediatric pulmonology, 2019, Volume: 54, Issue:9 Topics: Adolescent; Adult; Aminophenols; Child; Chloride Channel Agonists; Chlorides; Compassionate Use Trials; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Forced Expiratory Volume; Humans; Ion Channel Gating; Lung; Male; Middle Aged; Mutation; Quinolones; Respiratory Function Tests; Retrospective Studies; Sweat	2019
Changes in Airway Microbiome and Inflammation with Ivacaftor Treatment in Patients with Cystic Fibrosis and the G551D Mutation. Annals of the American Thoracic Society, 2020, Volume: 17, Issue:2 Topics: Adolescent; Adult; Aminophenols; Biomarkers; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Forced Expiratory Volume; Humans; Longitudinal Studies; Lung; Male; Microbiota; Mutation; Pseudomonas aeruginosa; Pseudomonas Infections; Quinolones; Respiratory System Agents; Sputum; Sweat; Treatment Outcome; Young Adult	2020
Females with Cystic Fibrosis Demonstrate a Differential Response Profile to Ivacaftor Compared with Males. American journal of respiratory and critical care medicine, 2020, 04-15, Volume: 201, Issue:8 Topics: Adolescent; Adult; Age Factors; Aminophenols; Body Mass Index; Body Weight; Child; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Disease Progression; Female; Forced Expiratory Volume; Humans; Male; Quinolones; Sex Factors; Sweat; Young Adult	2020
Females with cystic fibrosis have a larger decrease in sweat chloride in response to lumacaftor/ivacaftor compared to males. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021, Volume: 20, Issue:1 Topics: Adolescent; Adult; Aminophenols; Aminopyridines; Benzodioxoles; Body Mass Index; Child; Chlorides; Correlation of Data; Cystic Fibrosis; Drug Combinations; Female; Forced Expiratory Volume; Humans; Male; Quinolones; Retrospective Studies; Sex Factors; Sweat; Young Adult	2021
Comparison of Organoid Swelling and American journal of respiratory and critical care medicine, 2020, 12-01, Volume: 202, Issue:11 Topics: Adolescent; Adult; Aminophenols; Aminopyridines; Benzodioxoles; Child; Chlorides; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Combinations; Edema; Female; Forced Expiratory Volume; Homozygote; Humans; In Vitro Techniques; Male; Membrane Potentials; Middle Aged; Nasal Mucosa; Organoids; Precision Medicine; Prospective Studies; Quinolones; Rectum; Sweat; Treatment Outcome; Vital Capacity; Young Adult	2020
Measuring the impact of CFTR modulation on sweat chloride in cystic fibrosis: Rationale and design of the CHEC-SC study. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021, Volume: 20, Issue:6 Topics: Adolescent; Adult; Aged; Aminophenols; Aminopyridines; Benzodioxoles; Child; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Combinations; Female; Humans; Male; Middle Aged; Prospective Studies; Quinolones; Sweat	2021
Optical Measurements of Sweat for in Vivo Quantification of CFTR Function in Individual Sweat Glands. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2021, Volume: 20, Issue:5 Topics: Aminophenols; Aminopyridines; Benzodioxoles; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Combinations; Humans; Optics and Photonics; Quinolones; Sweat; Sweat Glands	2021
CFTR modulation with elexacaftor-tezacaftor-ivacaftor in people with cystic fibrosis assessed by the β-adrenergic sweat rate assay. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 2022, Volume: 21, Issue:3 Topics: Adrenergic Agents; Aminophenols; Benzodioxoles; Chloride Channel Agonists; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Combinations; Humans; Indoles; Pyrazoles; Pyridines; Pyrrolidines; Quinolones; Sweat	2022
Synthesis of substituted N-benzyl pyridones via an O- to N-alkyl migration. The Journal of organic chemistry, 2008, Aug-15, Volume: 73, Issue:16 Topics: Alcohols; Alkylation; Benzyl Compounds; Iodides; Lithium Compounds; Pyridines; Pyridones; Pyrimidines; Pyrimidinones; Quinolines; Quinolones	2008
Spectroscopic studies on the binding of a new quinolone antibacterial agent: sinafloxacin to DNA. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2009, Volume: 25, Issue:11 Topics: Animals; Anti-Bacterial Agents; Cattle; DNA; Fluorescence Polarization; Fluoroquinolones; Iodides; Nucleic Acid Denaturation; Osmolar Concentration; Quinolones; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Transition Temperature; Viscosity	2009
4-Aryl-2-quinolones from 3,3-diarylacrylamides through intramolecular copper-catalyzed C-H functionalization/C-N bond formation. The Journal of organic chemistry, 2012, Mar-02, Volume: 77, Issue:5 Topics: Amides; Catalysis; Copper; Cyclization; Hydroxyquinolines; Iodides; Molecular Structure; Quinolones	2012
CFTR potentiators partially restore channel function to A561E-CFTR, a cystic fibrosis mutant with a similar mechanism of dysfunction as F508del-CFTR. British journal of pharmacology, 2014, Volume: 171, Issue:19 Topics: Aminophenols; Animals; Biotinylation; Cell Line; Cricetinae; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Genistein; Iodides; Ion Channel Gating; Mutation; Quinolones; Temperature	2014