interleukin-8 and sphingadienine

interleukin-8 has been researched along with sphingadienine* in 1 studies

Other Studies

1 other study(ies) available for interleukin-8 and sphingadienine

Article	Year
Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine. International journal of molecular medicine, 2012, Volume: 30, Issue:3 Sphingolipids (SLs) are a class of lipids, which are structural cell components involved in the regulation of cellular processes such as cell proliferation, differentiation, apoptosis and inflammation. Dietary SLs are enzymatically hydrolyzed in the gut lumen into metabolites, namely ceramides and sphingoid bases. The sphingoid base 4,8-sphingadienine (4,8-SD) is the metabolite of glucocerebrosides derived from plants that are part of the human diet. The present findings provide insight into the effects of 4,8-SD on inflammatory responses that may be of nutritional and therapeutic benefit. We demonstrated that 4,8-SD significantly inhibited tumor necrosis factor-α (TNF-α)- and lipopolysaccharide (LPS)-induced expression of IL-8 and E-selectin in human endothelial cells in a dose-dependent manner. The anti-inflammatory effect was observed at significantly lower concentrations of 4,8-SD compared those affecting cell viability as judged by the LDH and WST-1 assays. Topics: Arisaema; Cell Survival; E-Selectin; Ethanolamines; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Interleukin-8; Tumor Necrosis Factor-alpha	2012

Article

Year

Effects on inflammatory responses by the sphingoid base 4,8-sphingadienine.

International journal of molecular medicine, 2012, Volume: 30, Issue:3

Sphingolipids (SLs) are a class of lipids, which are structural cell components involved in the regulation of cellular processes such as cell proliferation, differentiation, apoptosis and inflammation. Dietary SLs are enzymatically hydrolyzed in the gut lumen into metabolites, namely ceramides and sphingoid bases. The sphingoid base 4,8-sphingadienine (4,8-SD) is the metabolite of glucocerebrosides derived from plants that are part of the human diet. The present findings provide insight into the effects of 4,8-SD on inflammatory responses that may be of nutritional and therapeutic benefit. We demonstrated that 4,8-SD significantly inhibited tumor necrosis factor-α (TNF-α)- and lipopolysaccharide (LPS)-induced expression of IL-8 and E-selectin in human endothelial cells in a dose-dependent manner. The anti-inflammatory effect was observed at significantly lower concentrations of 4,8-SD compared those affecting cell viability as judged by the LDH and WST-1 assays.

Topics: Arisaema; Cell Survival; E-Selectin; Ethanolamines; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Interleukin-8; Tumor Necrosis Factor-alpha

2012