interleukin-8 and sinulariolide

interleukin-8 has been researched along with sinulariolide* in 1 studies

Other Studies

1 other study(ies) available for interleukin-8 and sinulariolide

Article	Year
A soft coral natural product, 11-episinulariolide acetate, inhibits gene expression of cyclooxygenase-2 and interleukin-8 through attenuation of calcium signaling. Molecules (Basel, Switzerland), 2013, Jun-17, Volume: 18, Issue:6 Epidermal growth factor receptor (EGFR) is overexpressed in many types of cancer cells. EGFR-mediated signaling involves inflammatory gene expression including cyclooxygenase (COX)-2 and interleukin (IL)-8, and is associated with cancer pathogenesis. In a search of phytochemicals with anti-inflammatory activity, the COX-2 and IL-8 inhibitory activities of some marine compounds were examined. After screening these compounds 11-episinulariolide acetate (1) from soft coral exhibited the most potent activity. Reverse-transcription PCR; western blotting; ELISA and luciferase assays were used to test the effect of compound 1 on EGF-stimulated expressions of COX-2 and IL-8 in A431 human epidermoid carcinoma cells. After exposure to 10 μM of compound 1, expression levels of COX-2 and IL-8 were reduced. In addition; intracellular Ca²⁺ increase and Ca²⁺-dependent transcription factor activation were blocked by compound 1. Thus, compound 1 can potentially serve as a lead compound for targeting Ca²⁺ signaling-dependent inflammatory diseases. Topics: Animals; Anthozoa; Biological Products; Calcium Signaling; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diterpenes; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gene Expression Regulation; Humans; Interleukin-8; NF-kappa B; NFATC Transcription Factors; Signal Transduction	2013

Article

Year

A soft coral natural product, 11-episinulariolide acetate, inhibits gene expression of cyclooxygenase-2 and interleukin-8 through attenuation of calcium signaling.

Molecules (Basel, Switzerland), 2013, Jun-17, Volume: 18, Issue:6

Epidermal growth factor receptor (EGFR) is overexpressed in many types of cancer cells. EGFR-mediated signaling involves inflammatory gene expression including cyclooxygenase (COX)-2 and interleukin (IL)-8, and is associated with cancer pathogenesis. In a search of phytochemicals with anti-inflammatory activity, the COX-2 and IL-8 inhibitory activities of some marine compounds were examined. After screening these compounds 11-episinulariolide acetate (1) from soft coral exhibited the most potent activity. Reverse-transcription PCR; western blotting; ELISA and luciferase assays were used to test the effect of compound 1 on EGF-stimulated expressions of COX-2 and IL-8 in A431 human epidermoid carcinoma cells. After exposure to 10 μM of compound 1, expression levels of COX-2 and IL-8 were reduced. In addition; intracellular Ca²⁺ increase and Ca²⁺-dependent transcription factor activation were blocked by compound 1. Thus, compound 1 can potentially serve as a lead compound for targeting Ca²⁺ signaling-dependent inflammatory diseases.

Topics: Animals; Anthozoa; Biological Products; Calcium Signaling; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diterpenes; Dose-Response Relationship, Drug; Epidermal Growth Factor; Gene Expression Regulation; Humans; Interleukin-8; NF-kappa B; NFATC Transcription Factors; Signal Transduction

2013