interleukin-8 and panipenem-betamipron

interleukin-8 has been researched along with panipenem-betamipron* in 1 studies

Trials

1 trial(s) available for interleukin-8 and panipenem-betamipron

ArticleYear
[Change of cytokines and clinical efficacy of panipenem/betamipron in obstetric and gynecological infections. Yamagata Study Group of Panipenem/Betamipron in Obstetric and Gynecological Infections].
    The Japanese journal of antibiotics, 1998, Volume: 51, Issue:1

    Efficacy and safety of panipenem/betamipron (PAPM/BP) in treatment of obstetric and gynecological infections, and change of interleukin-6 (IL-6) and interleukin-8 (IL-8) levels in blood, as markers of infection, were investigated. The results were as follows; 1) Clinical efficacy of PAPM/BP by drip infusion of 1-2 g/day for 3-14 days against 52 patients with intrauterine infection (n = 29), pelveoperitonitis (n = 19), and other infections were 14 "Excellent" in 14 cases, "Good" in 35 cases, and efficacy rate was 94.2% (49/52). Both efficacy rate analy by causative organisms and eradication rate were 35/37 (94.6%). No subjective or objective side effects and no abnormal labolatory findings were observed. 2) Changes of IL-6 (> 4 pg/ml) levels in serum, as an infection marker, were observed in 8 cases out of 14 cases (57.1%), and correlation between CRP and IL-6 in the treatment process was noticed. However, changes of serum IL-8 (> 12.5 pg/ml) were observed in only 2 cases of those 14 cases (14.3%), indicative that IL-8 has no significance as a marker of infection.

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bacterial Infections; beta-Alanine; Biomarkers; Drug Therapy, Combination; Female; Genital Diseases, Female; Humans; Interleukin-6; Interleukin-8; Middle Aged; Pelvic Inflammatory Disease; Peritonitis; Thienamycins; Uterine Diseases

1998