interleukin-8 and malic-acid

interleukin-8 has been researched along with malic-acid* in 2 studies

Other Studies

2 other study(ies) available for interleukin-8 and malic-acid

Article	Year
Bovine tumor necrosis factor-alpha Increases IL-6, IL-8, and PGE2 in bovine fibroblast-like synoviocytes by metabolic reprogramming. Scientific reports, 2023, 02-24, Volume: 13, Issue:1 Topics: Animals; Arthritis, Rheumatoid; Cattle; Cells, Cultured; Cyclooxygenase 2; Cytokines; Dinoprostone; Fibroblasts; Interleukin-6; Interleukin-8; Lameness, Animal; Malates; Phosphatidylinositol 3-Kinases; Synovial Membrane; Synoviocytes; Tumor Necrosis Factor-alpha	2023
Novel bioactive maloyl glucans from aloe vera gel: isolation, structure elucidation and in vitro bioassays. Carbohydrate research, 2006, Feb-27, Volume: 341, Issue:3 In this study, three novel maloyl glucans were isolated at temperatures below 15 degrees C from aloe vera gel (Aloe barbadensis Miller). These compounds were characterized using NMR spectroscopy, ESIMS, MALDITOF-MS and capillary electrophoresis. The compounds were characterized as 6-O-(1-L-maloyl)-alpha-,beta-D-Glcp (veracylglucan A), alpha-D-Glcp-(1-->4)-6-O-(1-L-maloyl)-alpha,-beta,-D-Glcp (veracylglucan B) and alpha-D-Glcp-(1-->4)-tetra-[6-O-(1-L-maloyl)-alpha-D-Glcp-(1-->4)]-6-O-(1-L-maloyl)-alpha,-beta-D-Glcp (veracylglucan C). These unusual malic acid acylated carbohydrates were then tested in vitro for effects on cell proliferation and gene expression of proinflammatory cytokines, IL-6, IL-8 and ICAM-1, using RT-PCR. Veracylglucan B demonstrated potent anti-inflammatory and anti-proliferative effects, while Veracylglucan C, on the other hand, exhibited significant cell proliferative and anti-inflammatory activities. Veracylglucan A could only be isolated in smaller quantities, and it proved to be very unstable. Thus no biological effects could be observed in this respect. The in vitro bioassays also indicated that Veracylglucan B and C are antagonistic and competitive in their effects on cell proliferation. The results of this work represent a major step forward in the research on aloe vera gel. This is the first time that two fully chemically characterized compounds are shown to be responsible for known biological activities of aloe vera gel. Topics: Acylation; Aloe; Biological Assay; Carbohydrate Sequence; Carbohydrates; Cell Proliferation; Cells, Cultured; Electrophoresis, Capillary; Fibroblasts; Glucans; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Interleukin-6; Interleukin-8; Keratinocytes; Magnetic Resonance Spectroscopy; Malates; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2006

Article

Year

Bovine tumor necrosis factor-alpha Increases IL-6, IL-8, and PGE2 in bovine fibroblast-like synoviocytes by metabolic reprogramming.

Scientific reports, 2023, 02-24, Volume: 13, Issue:1

Topics: Animals; Arthritis, Rheumatoid; Cattle; Cells, Cultured; Cyclooxygenase 2; Cytokines; Dinoprostone; Fibroblasts; Interleukin-6; Interleukin-8; Lameness, Animal; Malates; Phosphatidylinositol 3-Kinases; Synovial Membrane; Synoviocytes; Tumor Necrosis Factor-alpha

2023

Novel bioactive maloyl glucans from aloe vera gel: isolation, structure elucidation and in vitro bioassays.

Carbohydrate research, 2006, Feb-27, Volume: 341, Issue:3

In this study, three novel maloyl glucans were isolated at temperatures below 15 degrees C from aloe vera gel (Aloe barbadensis Miller). These compounds were characterized using NMR spectroscopy, ESIMS, MALDITOF-MS and capillary electrophoresis. The compounds were characterized as 6-O-(1-L-maloyl)-alpha-,beta-D-Glcp (veracylglucan A), alpha-D-Glcp-(1-->4)-6-O-(1-L-maloyl)-alpha,-beta,-D-Glcp (veracylglucan B) and alpha-D-Glcp-(1-->4)-tetra-[6-O-(1-L-maloyl)-alpha-D-Glcp-(1-->4)]-6-O-(1-L-maloyl)-alpha,-beta-D-Glcp (veracylglucan C). These unusual malic acid acylated carbohydrates were then tested in vitro for effects on cell proliferation and gene expression of proinflammatory cytokines, IL-6, IL-8 and ICAM-1, using RT-PCR. Veracylglucan B demonstrated potent anti-inflammatory and anti-proliferative effects, while Veracylglucan C, on the other hand, exhibited significant cell proliferative and anti-inflammatory activities. Veracylglucan A could only be isolated in smaller quantities, and it proved to be very unstable. Thus no biological effects could be observed in this respect. The in vitro bioassays also indicated that Veracylglucan B and C are antagonistic and competitive in their effects on cell proliferation. The results of this work represent a major step forward in the research on aloe vera gel. This is the first time that two fully chemically characterized compounds are shown to be responsible for known biological activities of aloe vera gel.

Topics: Acylation; Aloe; Biological Assay; Carbohydrate Sequence; Carbohydrates; Cell Proliferation; Cells, Cultured; Electrophoresis, Capillary; Fibroblasts; Glucans; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1; Interleukin-6; Interleukin-8; Keratinocytes; Magnetic Resonance Spectroscopy; Malates; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2006