interleukin-8 and indole-3-carbinol

interleukin-8 has been researched along with indole-3-carbinol* in 1 studies

Other Studies

1 other study(ies) available for interleukin-8 and indole-3-carbinol

Article	Year
Inhibition of cell proliferation and in vitro markers of angiogenesis by indole-3-carbinol, a major indole metabolite present in cruciferous vegetables. Journal of agricultural and food chemistry, 2005, Jun-29, Volume: 53, Issue:13 A variety of studies have suggested a cancer protective role of cruciferous vegetables. In the present study, we investigated the effect of indole-3-carbinol (I3C), a major indole metabolite in cruciferous vegetables, on cell proliferation and in vitro markers of angiogenesis in phorbol myristate acetate (PMA)-stimulated endothelial EA hy926 cells. The results showed that I3C inhibited the growth of EA hy926 cells in a concentration-dependent manner. The capillary-like tube formation by PMA-activated endothelial cells was significantly suppressed by I3C, and such inhibition was associated with decreased vascular endothelial growth factor (VEGF) and increased interleukin-8 (IL-8) secretion, but not with the expression of VEGF receptor-2 protein. Additionally, gelatin zymography analysis indicated that I3C suppressed activities of matrix metalloproteinases-2 (MMP-2) and MMP-9 stimulated by PMA. These results suggest that the dietary I3C may be useful in the treatment of human cancers and angiogenic diseases. Topics: Brassicaceae; Cell Division; Cell Line; Endothelial Cells; Enzyme Inhibitors; Humans; Indoles; Interleukin-8; Matrix Metalloproteinase Inhibitors; Neovascularization, Physiologic; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vegetables	2005

Article

Year

Inhibition of cell proliferation and in vitro markers of angiogenesis by indole-3-carbinol, a major indole metabolite present in cruciferous vegetables.

Journal of agricultural and food chemistry, 2005, Jun-29, Volume: 53, Issue:13

A variety of studies have suggested a cancer protective role of cruciferous vegetables. In the present study, we investigated the effect of indole-3-carbinol (I3C), a major indole metabolite in cruciferous vegetables, on cell proliferation and in vitro markers of angiogenesis in phorbol myristate acetate (PMA)-stimulated endothelial EA hy926 cells. The results showed that I3C inhibited the growth of EA hy926 cells in a concentration-dependent manner. The capillary-like tube formation by PMA-activated endothelial cells was significantly suppressed by I3C, and such inhibition was associated with decreased vascular endothelial growth factor (VEGF) and increased interleukin-8 (IL-8) secretion, but not with the expression of VEGF receptor-2 protein. Additionally, gelatin zymography analysis indicated that I3C suppressed activities of matrix metalloproteinases-2 (MMP-2) and MMP-9 stimulated by PMA. These results suggest that the dietary I3C may be useful in the treatment of human cancers and angiogenic diseases.

Topics: Brassicaceae; Cell Division; Cell Line; Endothelial Cells; Enzyme Inhibitors; Humans; Indoles; Interleukin-8; Matrix Metalloproteinase Inhibitors; Neovascularization, Physiologic; Tetradecanoylphorbol Acetate; Vascular Endothelial Growth Factor A; Vegetables

2005