interleukin-8 and flavanone

As part of an ongoing search for new natural products from medicinal plants to treat respiratory disease, six new compounds, a dihydroflavonol (1) and five C-geranylated flavanones (3, 6, 8, 13, and 14), and 13 known compounds were isolated from mature fruits of Paulownia tomentosa. The structures of the new compounds were determined via interpretation of their spectroscopic data (1D and 2D NMR, UV, IR, ECD, and MS). In biological activity assays with human alveolar basal epithelial cells, the expression of TNF-α-induced proinflammatory cytokines (IL-8 and IL-6) was reduced significantly by the EtOAc fraction of a P. tomentosa extract as well as by the new compounds isolated from this fraction. Furthermore, the majority of the isolates (1-19 except 5-7) were found to inhibit human neutrophil elastase (HNE) activity, with IC

Topics: Anti-Inflammatory Agents, Non-Steroidal; Flavanones; Fruit; Humans; Interleukin-6; Interleukin-8; Magnoliopsida; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Proteinase Inhibitory Proteins, Secretory; Republic of Korea; Tumor Necrosis Factor-alpha