interleukin-8 and epinastine

interleukin-8 has been researched along with epinastine* in 1 studies

Other Studies

1 other study(ies) available for interleukin-8 and epinastine

Article	Year
A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils. Biochemical and biophysical research communications, 1997, Jan-03, Volume: 230, Issue:1 Eosinophils are believed to be one of the important sources of cytokines at the site of allergic inflammation. A novel antiallergic agent epinastine showed a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases. The time-dependent accumulation of IL-8 inhibited by cycloheximide and the evaluation of the IL-8 mRNA levels by reverse transcriptase-polymerase chain reaction suggested that its action occurred in the posttranscriptional processes. It was suggested that epinastine might prevent the autocrine cycle for recruitment of human eosinophils by inhibiting IL-8 release from these cells. Topics: Calcimycin; Cells, Cultured; Chemokine CCL5; Dibenzazepines; DNA Primers; Enzyme-Linked Immunosorbent Assay; Eosinophils; Histamine H1 Antagonists; Humans; Imidazoles; Interleukin-8; Kinetics; Polymerase Chain Reaction; Transcription, Genetic	1997

Article

Year

A novel antiallergic drug epinastine inhibits IL-8 release from human eosinophils.

Biochemical and biophysical research communications, 1997, Jan-03, Volume: 230, Issue:1

Eosinophils are believed to be one of the important sources of cytokines at the site of allergic inflammation. A novel antiallergic agent epinastine showed a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases. The time-dependent accumulation of IL-8 inhibited by cycloheximide and the evaluation of the IL-8 mRNA levels by reverse transcriptase-polymerase chain reaction suggested that its action occurred in the posttranscriptional processes. It was suggested that epinastine might prevent the autocrine cycle for recruitment of human eosinophils by inhibiting IL-8 release from these cells.

Topics: Calcimycin; Cells, Cultured; Chemokine CCL5; Dibenzazepines; DNA Primers; Enzyme-Linked Immunosorbent Assay; Eosinophils; Histamine H1 Antagonists; Humans; Imidazoles; Interleukin-8; Kinetics; Polymerase Chain Reaction; Transcription, Genetic

1997