interleukin-8 has been researched along with coumarin-6* in 1 studies
1 other study(ies) available for interleukin-8 and coumarin-6
| Article | Year |
|---|---|
Synthesis, characterization and evaluation of in vitro toxicity in hepatocytes of linear polyesters with varied aromatic and aliphatic co-monomers.
Polyesters are extensively used in drug delivery because of their controllable biodegradation properties and perceived favorable cytocompatibility. However, new ester-based materials are continually being sought which can be produced from readily accessible monomers, which can be tuned for drug encapsulation and which retain good cellular compatibilities. In this study, 5 polyesters of similar molar mass were synthesized by reacting 1,10-decanediol with different ratios of succinic acid/phenylsuccinic acid and the effect of the phenyl side-chain group addition on polymer properties relevant to drug delivery was investigated. A polymer with a 70/30 ratio of succinic acid and phenylsuccinic acid was selected based on its ability to encapsulate a model dye in nanoparticle (NP) formulations, and was found to be slowly degradable in phosphate buffered saline (PBS) but more rapidly degraded in the presence of a lipase. The compatibility of NP formulations of this polymer either with or without a Pluronic F68 stabilizing coating was assessed in vitro using the C3A hepatocyte cell line. Cell viability was assessed, at NP concentrations ranging from 4.68-300μgmL Topics: Cell Line, Tumor; Cell Survival; Comet Assay; Coumarins; DNA Damage; Fatty Alcohols; Fluorescent Dyes; Hepatocytes; Humans; Interleukin-8; Nanoparticles; Poloxamer; Polyesters; Succinates; Thiazoles | 2016 |