inositol has been researched along with sorbitol in 343 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 171 (49.85) | 18.7374 |
| 1990's | 118 (34.40) | 18.2507 |
| 2000's | 34 (9.91) | 29.6817 |
| 2010's | 17 (4.96) | 24.3611 |
| 2020's | 3 (0.87) | 2.80 |
| Authors | Studies |
|---|---|
| Anderson, RA; Oswald, C; Zaneveld, LJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Deguchi, E; Koumoto, K | 1 |
| Richards, RD; Schocket, SS; Varma, SD | 1 |
| Hollows, FC; Hutton, JC; Schofield, PJ; Williams, JF | 3 |
| Hollows, FC; Hutton, JC; Regtop, HL; Schofield, PH; Williams, JF | 1 |
| Hothersall, JS; McLean, P | 1 |
| Ismail, RM; Otto, KJ | 1 |
| Daumerie-Goffinet, C; Lambert, AE | 1 |
| Gould, NJ; Schofield, PJ | 1 |
| van der Horst, CJ; Vogel, F | 1 |
| Hawthorne, JN; Pickard, MR | 1 |
| Bowman, RJ; Lwitt, DG | 1 |
| Palo, J; Pitkänen, E; Servo, C | 2 |
| Bergström, L; Fogelholm, R; Servo, C | 1 |
| Jakinovich, W; Oakley, B | 1 |
| Renold, AE | 1 |
| Lorenzo, AV; Spector, R | 1 |
| Galton, DJ; Heaf, DJ | 1 |
| Pitkänen, E; Servo, C | 2 |
| Ito, H; Kanazawa, A; Miwa, T; Ohno, A; Tanaka, A | 1 |
| Del Monte, MA; Greene, DA; Lattimer, SA; Nakamura, J; Shewach, D | 1 |
| Hisanaga, T; Kawabata, T; Kikkawa, R; Maeda, K; Shigeta, Y; Sonobe, M; Yasuda, H | 1 |
| Kato, N; Kurono, M; Matsubara, A; Mizuno, K; Nakano, K | 1 |
| Beyer-Mears, A; Fusilli, LD; Regan, TJ; Torres, R | 1 |
| Brownlee, M | 1 |
| Aida, K; Onaya, T; Shindo, H; Tawata, M | 1 |
| Diemel, LT; Stevens, EJ; Tomlinson, DR; Willars, GB | 1 |
| Brown, ML; Cohen, RA; Tesfamariam, B | 1 |
| Asahina, T; Ikebuchi, M; Kashiwagi, A; Kida, Y; Obata, T; Ogawa, T; Saeki, Y; Suzaki, M; Takagi, Y; Tanaka, Y | 1 |
| Cameron, NE; Cotter, MA; Dines, K; Love, A | 1 |
| Cammarata, PR; Chen, HQ; Yang, J; Yorio, T | 2 |
| Guder, WG; Schleicher, E; Schmolke, M | 1 |
| Beyer-Mears, A; Cruz, E; Diecke, FP; Mistry, K | 2 |
| McCaleb, ML; Sredy, J | 1 |
| Hisanaga, T; Kawabata, T; Kikkawa, R; Maeda, K; Shigeta, Y; Sonobe, M; Taniguchi, Y; Yamashita, M; Yasuda, H | 1 |
| Nakanishi, T; Sugita, M; Uyama, O | 1 |
| Freinkel, N; Hod, M; Passonneau, JV; Star, S; Unterman, TG | 2 |
| Bornemann, A; Guder, WG; Schmolke, M | 3 |
| Das, AK; Vijayaraghavan, MV | 1 |
| Dunlap, JA; Yorek, MA | 2 |
| Flam, BR; Sawicki, DR; Sredy, J | 1 |
| Kito, S; Yamamura, Y | 1 |
| Wasada, T | 1 |
| Acara, M; Bennett, MI; Lohr, JW; McReynolds, J; Pochal, MA; Willsky, GR | 1 |
| Burg, MB; Garcia-Perez, A; Moriyama, T; Olson, AD | 1 |
| Futterweit, S; Hammer, E; Oates, P; Siegel, TW; Trachtman, H | 1 |
| Eto, M; Ishii, K; Iwashima, Y; Makino, I; Morikawa, A; Sekiguchi, M; Takahashi, M; Watanabe, K | 1 |
| Burg, MB; Garcia-Perez, A | 2 |
| Brennan, MC; Del Monte, MA; Diaz, TC; Greene, DA; Lattimer, SA; Nakamura, J; Rabbani, R | 1 |
| Iwamoto, Y | 1 |
| Chang, K; Eades, DM; Kilo, C; Lacy, PE; Province, M; Pugliese, G; Speedy, A; Tilton, RG; Williamson, JR | 1 |
| Dunlap, JA; Leeney, EM; Stefani, MR; Yorek, MA | 1 |
| Shafrir, E | 1 |
| Akashi, M; Akazawa, M; Akazawa, S; Hashimoto, M; Maeda, Y; Nakanishi, T; Tahara, D; Yamaguchi, Y; Yamamoto, H; Yamasaki, H | 1 |
| Goto, Y; Hirata, Y; Okada, K; Suzuki, K; Toyota, T; Yen-Chung, H | 1 |
| Cook, WR; Lowitt, S; Malone, JI | 1 |
| Ido, Y; Kamijo, M; Mirrlees, DJ; Yagihashi, S | 1 |
| Berti-Mattera, LN; Bianchi, R; Eichberg, J; Fiori, MG | 1 |
| Lu, KM; Zhong, XL; Zhu, QY; Zhu, XX | 1 |
| Balaban, RS; Wolff, SD | 1 |
| Ghosh, A; Loy, A; Lurie, KG; MacGregor, LC; Matschinsky, FM; Wilson, JM | 1 |
| Brenner, RM; Gullans, SR; Heilig, CW; Kone, BC; Yu, AS | 1 |
| Burg, MB; Garcia-Perez, A; Moriyama, T | 1 |
| Freinkel, N; Hod, M; Passonneau, J; Star, S; Unterman, TG | 1 |
| Beck, FX; Guder, WG; Schmolke, M | 3 |
| Eades, DM; Kilo, C; Province, MA; Pugliese, G; Santarelli, E; Sherman, WR; Speedy, A; Tilton, RG; Williamson, JR | 1 |
| Burg, MB; Nakanishi, T; Turner, RJ | 1 |
| Chan, L; Lien, YH; Shapiro, JI | 1 |
| Mayer, JH; Tomlinson, DR | 4 |
| Larsen, JR; Sidenius, P; Tomlinson, DR | 1 |
| Greene, DA | 2 |
| Robinson, JP; Tomlinson, DR; Willars, GB | 1 |
| Agathos, SN; Demain, AL | 1 |
| Tomlinson, DR; Townsend, J; Whiteley, SJ; Willars, GB | 1 |
| Calthrop-Owen, EF; Tomlinson, DR; Willars, GB | 1 |
| Archer, DR; Dahlin, LB; McLean, WG | 1 |
| Churchill, RD; Compton, AM; Tomlinson, DR; Townsend, J; Willars, GB | 1 |
| Calcutt, NA; Tomlinson, DR; Willars, GB | 2 |
| Compton, AM; Keen, P; Robinson, JP; Tomlinson, DR | 1 |
| Capogreco, C; Fisher, E; Heffernan, S; McLennan, S; Ross, GR; Turtle, JR; Yue, DK | 1 |
| Plurad, SB; Schmidt, RE; Sherman, WR; Tilton, RG; Williamson, JR | 1 |
| Alloussi, S; Birlouez-Aragon, I; Fevrier, C; Morawiec, M | 1 |
| Eades, DM; Sherman, WR; Williamson, JR | 1 |
| Balaban, RS; James, SL; Stanton, TS; Wolff, SD | 1 |
| Brivet, M; Cheron, G; Lemonnier, A; Migayron, F; Roger, J | 1 |
| Cameron, NE; Cotter, MA; Robertson, S | 1 |
| Siebens, AW; Spring, KR | 1 |
| Hatanaka, I; Huitian, Z; Shigeta, Y; Sonobe, M; Terada, M; Yamashita, M; Yasuda, H | 1 |
| Airey, CM; Kemp, JV; Perkins, CM; Price, DE; Wales, JK | 1 |
| Fluharty, SJ; King, GL; Lee, TS; MacGregor, LC | 1 |
| Hu, TS; Li, WY; Qin, M; Tang, L; Zhou, Q | 1 |
| Li, WY | 1 |
| Greene, DA; Lattimer-Greene, S; Sima, AA | 1 |
| Umehara, F | 1 |
| Gullans, SR; Heilig, CW; Stromski, ME | 1 |
| Craven, PA; DeRubertis, FR; Lauro, PN | 1 |
| Alberti, KG; Bartlett, K; Hawthorne, GC; Hetherington, CS | 1 |
| Tomlinson, DR | 1 |
| Dyck, PJ; Minnerath, SR; O'Brien, PC | 1 |
| Goldstein, L | 1 |
| Burg, MB; Yancey, PH | 1 |
| Ashton, MA; Beyer, TA; Goddu, KJ; Hutson, NJ; Rafford, CE; Yeh, LA | 1 |
| Fujimori, S; Hirata, Y; Okada, K | 1 |
| Greene, DA; Lattimer, SA; Sima, AA | 2 |
| Grunewald, RW; Jans, AW; Kinne, RK | 1 |
| Guder, WG; Lefrank, S; Schmolke, M; Wirthensohn, G | 1 |
| Low, PA; Schmelzer, JD; Ward, KK; Yao, JK | 1 |
| Greene, DA; Lattimer, SA | 4 |
| MacGregor, LC; Matschinsky, FM | 2 |
| Cohen, M | 1 |
| Chakrabarti, S; Greene, DA; Lattimer, SA; Sima, AA | 1 |
| Yancey, PH | 1 |
| Dvornik, D; Kemper, C | 1 |
| Dunlap, JA; Ginsberg, BH; Yorek, MA | 2 |
| Belbeoc'h, C; Hirano, M; Inagaki, K; Miwa, I; Okuda, J | 1 |
| Bellomo, G; Comstock, JP; Hazelwood, RL; Wen, D | 1 |
| Airey, CM; Alani, SM; Price, DE; Wales, JK | 1 |
| Dyck, PJ; Karnes, JL; Minnerath, SR; Poduslo, JF; Vilen, TH; Yao, JK; Zimmerman, BR | 1 |
| Ross, IS; Whiting, PH | 1 |
| Tomlinson, DR; Whiteley, SJ | 1 |
| Kanbara, M; Miwa, I; Okuda, J; Wakazono, H | 1 |
| Hatanaka, I; Kikkawa, R; Shigeta, Y; Sonobe, M; Terada, M; Yamashita, M; Yasuda, H | 1 |
| Carson, MP; McCall, AL; Ruderman, NB; Schultz, V; Sussman, I; Tornheim, K; Wu, XP | 1 |
| Amenomori, M; Hatanaka, I; Kikkawa, R; Miyamoto, Y; Motoyama, Y; Shigeta, Y; Sonobe, M; Terada, M; Yamashita, M; Yasuda, H | 1 |
| Fujimori, S; Hirata, Y; Okada, K; Segawa, M | 1 |
| Matschinsky, FM; Sussman, I | 1 |
| Acara, M; Grimaldi, T; Lohr, JW; McReynolds, J | 1 |
| Balaban, RS; Burg, MB | 1 |
| Hawthorne, JN; King, RH; Llewelyn, JG; Simpson, CM; Thomas, PK | 1 |
| Hale, PJ; Nattrass, M; Perkins, CM; Sennit, C; Silverman, SH; Sundkvist, G; Uden, A | 1 |
| Inaba, H; Kato, K; Yano, T | 1 |
| Arlot, S; Lalau, JD; Quichaud, J | 1 |
| Beyer-Mears, A; Cruz, E | 1 |
| Burgess, SE; Cheng, H; Crabbe, MJ; Petchey, M | 1 |
| Ackermann, KE; Berger, RA; Chang, K; Kilo, C; Marvel, J; Rowold, E; Sherman, WR; Tomlinson, M; Williamson, JR | 1 |
| Laties, AM; MacGregor, LC; Matschinsky, FM; Rosecan, LR | 1 |
| Ackermann, KE; Chang, K; Kilo, C; Marvel, J; Rowold, E; Sherman, WR; Tomlinson, M; Williamson, JR | 1 |
| Aloia, JF; Nilakantan, S | 1 |
| Ivanova, GI; Pisareva, LN | 1 |
| Brown, DM; Stewart, JC | 1 |
| Brunner, A; Mogyoros, M; Piña, E | 1 |
| Fouquet, JP | 2 |
| MacKenzie, AP; Orndorff, GR | 1 |
| Ko, HL; Pulverer, G | 1 |
| Dettor, CM; Dewey, WC; Noel, JS; Winans, LF | 1 |
| Aloia, JF | 1 |
| Van Heyningen, R | 1 |
| Plouvier, V | 1 |
| Prockop, LD | 1 |
| Chakrapani, B; Reddy, VN; Steen, D | 1 |
| Nobel, PS; Wang, CT | 1 |
| Lin, EC; Tanaka, S | 1 |
| Carlin, R; Cotlier, E | 1 |
| Lloyd, JB | 1 |
| Linari, G | 1 |
| Horning, EC; Horning, MG | 1 |
| Lee, D | 1 |
| Khomenko, NA; Kiseleva, BS | 1 |
| Hasegawa, K; Kimura, R; Takaku, I; Watanabe, Y | 1 |
| Litjens, JB; van der Horst, CJ | 1 |
| Field, RA; Gabbay, KH; Merola, LO | 1 |
| Ely, PA | 1 |
| Clark, JB; Graham, EF; Lewis, BA; Smith, F | 1 |
| Taylor, GL; Taylor, PM | 1 |
| Wainer, A | 1 |
| Ghosh, AK; Tandon, RN | 1 |
| Britton, HG; Huggett, AS; Nixon, DA | 1 |
| Mayer, JH; Moriarty, RJ; Tomlinson, DR | 1 |
| Mayer, JH; McLean, WG; Tomlinson, DR | 1 |
| Fukuda, M; Kuriyama, H; Sasaki, K | 1 |
| Bernstein, M; Finegold, D; Greene, DA; Lattimer, SA; Nolle, S | 1 |
| Gillon, KR; Hawthorne, JN; Tomlinson, DR | 1 |
| Beyer-Mears, A; Cohen, MP; Ku, L | 1 |
| Jakobs, C; Nyhan, WL; Sweetman, L; Warner, TG | 1 |
| Richards, RD; Varma, SD | 1 |
| Handelsman, DJ; Hanwell, MA; Satchell, PM; Turtle, JR; Yue, DK | 1 |
| Lomecky-Janousek, MZ; Popp-Snijders, C; Schouten, JA; van der Veen, EA | 1 |
| Kölling, D; Mäkinen, KK; Söderling, E | 1 |
| Dyck, PJ; Sherman, WR | 1 |
| Barker, SA; Garner, LC; Prchal, JT; Skalka, HW; Tomana, M | 1 |
| Crabbe, MJ; Petchey, M | 1 |
| Lerner, BC; Richards, RD; Varma, SD | 1 |
| Tarui, S | 1 |
| Gillon, KR; Hawthorne, JN; Mayhew, JA | 1 |
| Gillon, KR; Hawthorne, JN | 2 |
| Servo, C | 1 |
| Adrian, J; David, C; Frangne, R; Manent, PJ; Poiffait, A | 1 |
| Dyck, PJ; Grina, LA; Hallcher, LM; O'Brien, PC; Palumbo, PJ; Service, FJ; Sherman, WR; Swanson, CJ | 1 |
| Funahashi, M; Hayano, S; Komori, T; Ono, H | 1 |
| Bassène, E; Olschwang, D; Pousset, JL | 1 |
| Dayhaw-Barker, P | 1 |
| Burgan, JH; Nyengaard, JR; Ostrow, E; Van den Enden, MK; Williamson, JR | 1 |
| Fukasawa, H; Hamada, Y; Hara, T; Hotta, N; Kakuta, H; Koh, N; Mori, K; Nakamura, J; Sakakibara, F; Wakao, T | 1 |
| Burg, MB | 2 |
| Albrecht, BN; Florkiewicz, RZ; Lowe, WL; Spanheimer, RG; Yorek, MA | 1 |
| Chang, K; Corbett, JA; Currie, MG; Hasan, KS; McDaniel, ML; Misko, TP; Moore, WM; Petrash, JM; Smith, SR; Tilton, RG | 1 |
| Holloway, HW; Rapoport, SI; Shetty, HU | 1 |
| Bedford, JJ; Leader, JP; Smiley, M | 1 |
| Nukada, H; Wright, RA | 1 |
| Basso, M; Cherian, PV; Hohman, TC; Kamijo, M; Sima, AA | 1 |
| Beyer-Mears, A; Diecke, FP; Mistry, K | 1 |
| Arrigoni-Martelli, E; Chang, KC; Corr, PB; Ido, Y; Kilo, C; McHowat, J; Orfalian, Z; Williamson, JR | 1 |
| Agarwal, N; Cammarata, PR; Chen, HQ; Reeves, R; Zhou, C | 1 |
| Nakahama, H; Nakanishi, T; Sugita, M; Takamitsu, Y | 1 |
| Chatzilias, AA; Whiteside, CI | 1 |
| Davidson, EP; Dunlap, JA; Stefani, MR; Yorek, MA | 2 |
| Greene, DA; Kato, K; Porcellati, F; Sherman, WR; Stevens, MJ; Thomas, TP | 1 |
| Greene, DA; Henry, DN; Killen, PD; Stevens, MJ; Thomas, TP | 1 |
| Greene, DA; Kamijo, M; Lattimer, SA; Sima, AA; Stevens, MJ; Van Huysen, C | 1 |
| Calcutt, NA; Kalichman, MW; Mizisin, AP; Myers, RR; Powell, HC | 1 |
| Morrison, R; Putnam, R; Shrode, L; Strange, K | 1 |
| Hotta, N; Koh, N; Sakakibara, F; Sakamoto, N | 1 |
| Feldman, EL; Greene, DA; Kato, K; Lien, M; Nakamura, J; Stevens, MJ; Thomas, TP | 1 |
| Belpoliti, M; Maraini, G | 1 |
| Bason, LM; Chambers, ST; Lever, M; Robson, RA; Sizeland, PC | 1 |
| Nakahama, H; Nakanishi, T; Sugita, M; Takamitsu, Y; Uyama, O | 1 |
| García-Pérez, A | 1 |
| Cameron, NE; Cotter, MA; Maxfield, EK | 1 |
| Fukawa, E; Hirano, F; Inaba, M; Makino, I; Makino, Y; Miura, T; Nomura, Y; Okamoto, K; Tanaka, H; Tani, T | 1 |
| Greene, DA; Inada, H; Karihaloo, AK; Larkin, DD; Onaya, T; Shindo, H; Stevens, MJ; Thomas, TP | 1 |
| Greene, DA; Kamijo, M; Lattimer, SA; Merry, A; Ristic, H; Sima, AA; Stevens, MJ | 1 |
| Cameron, NE; Cotter, MA; Hohman, TC | 1 |
| Boersma, ER; Huisman, M; Lanting, CI; Muskiet, FA; Nijeboer, HJ; van Beusekom, CM | 1 |
| Andrews, PM; Burg, MB; Dooley, JA; García-Pérez, A; Jung, KY; Kwon, ED | 1 |
| Burg, MB; Ferraris, JD; García-Pérez, A; Peters, EM; Williams, CK | 1 |
| Nakanishi, T; Sugita, M; Takamitsu, Y; Yamauchi, A | 1 |
| Wieckowski, MR; Zabłocki, K | 1 |
| Besch-Williford, C; Clemons, DJ; O'Brien, DP; O'Dell, BL; Terril-Robb, LA | 1 |
| Guder, WG; Keiditsch, E; Schilling, A; Schmolke, M | 1 |
| Foote, RH; Liu, Z | 1 |
| Lowe, WL; Matsushita, K; Stokes, JB; Wiese, TJ; Yorek, MA | 1 |
| Fukasawa, H; Hamada, Y; Hara, T; Hotta, N; Kakuta, H; Koh, N; Nakamura, J; Sakakibara, F; Sakamoto, N | 1 |
| Nakanishi, T; Takamitsu, Y | 1 |
| Burg, MB; Kwon, ED; Peters, EM | 1 |
| Hamada, Y; Hotta, N; Kakuta, H; Koh, N; Matsubara, A; Mizuno, K; Nakamura, J; Naruse, K; Sakakibara, F; Sasaki, H | 1 |
| Basso, M; Cameron, NE; Cotter, MA; Hohman, TC | 1 |
| Handler, JS; Kwon, HM | 2 |
| Angen, O; Bisgaard, M; Caugant, DA; Olsen, JE | 1 |
| Imanishi, Y; Iwaguchi, SI; Kamihara, T; Suzuki, T | 1 |
| Calcutt, NA; Chung, SK; Chung, SS; Lee, AY; Lee, FK; Lee, LW; Ng, DT; Ng, TF; Song, ZT | 1 |
| Pierzchala, K | 1 |
| Busch, GL; Lang, F; Matskevitch, J; Waldegger, S | 1 |
| Kinne, RK | 1 |
| Asano, T; Fujishima, M; Iino, K; Nakamura, S; Takata, Y; Wakisaka, M; Yoshinari, M | 1 |
| Beck, FX; Burger-Kentischer, A; Fraek, ML; März, J; Müller, E; Thurau, K | 1 |
| Hotta, N; Kawamura, T; Sakakibara, F; Sakamoto, N; Sano, T; Sasaki, H; Suzuki, K | 1 |
| Barone, G; Del Vecchio, P; Esposito, D; Ricchi, L | 1 |
| Berkowitz, BA; Frank, RN; Hohman, TC; Kern, TS; Kowluru, RA; Prakash, M | 1 |
| Chaya, S; Hamada, Y; Hotta, N; Kasuya, Y; Kato, K; Komori, T; Nakamura, J; Nakashima, E; Nakayama, M; Naruse, K; Sasaki, H; Watanabe, G | 1 |
| Inada, H; Onaya, T; Shindo, H; Tawata, M | 1 |
| Kishi, Y; Low, PA; Nickander, KK; Schmelzer, JD; Tritschler, HJ; Yao, JK; Zollman, PJ | 1 |
| Beck, FX; Dörge, A; Fraek, ML; Müller, E; Thurau, K | 1 |
| Cammarata, PR; Chung, SK; Chung, SS; Jiang, Z; Zhou, C | 1 |
| Dahlin, LB; Eriksson, KF; Greene, DA; Lattimer, SA; Lindgärde, F; Nilsson, H; Rosén, I; Sima, AA; Sullivan, K; Sundkvist, G | 1 |
| Ikegami, H; Kariya, K; Tabata, H | 1 |
| Cao, X; Fathallah, L; Greene, DA; Obrosova, IG; Stevens, MJ; Van Huysen, C | 1 |
| Kato, N; Makino, M; Mizuno, K; Suzuki, T; Yagihashi, S | 1 |
| Fathallah, L; Obrosova, IG | 1 |
| Kawamori, R; Ohmura, C; Tanaka, Y; Uchino, H; Watanabe, K; Yoshii, H | 1 |
| Coppey, LJ; Davidson, EP; Dunlap, JA; Lund, DD; Yorek, MA | 1 |
| Coppey, LJ; Davidson, EP; Dunlap, JA; Gellett, JS; Lund, DD; Yorek, MA | 1 |
| Coppey, LJ; Davidson, EP; Dunlap, JA; Gellett, JS; Lund, DD; Salvemini, D; Yorek, MA | 1 |
| Fiedler, GM; Grunewald, RW; Jehle, PM; Oppermann, M; Schettler, V; Schuettert, JB | 1 |
| Farnum, CE; Lee, R; O'Hara, K; Urban, JP | 1 |
| Fogel, JM; Moeckel, GW; Sadrzadeh, SM; Shadman, R | 1 |
| Breyer, MD; Fogo, AB; Hao, CM; Moeckel, GW; Pozzi, A; Zhang, L | 1 |
| Fischer, H; Gullans, SR; Howard, M; Roux, J; Santos, BC; Welch, WJ; Yancey, PH | 1 |
| Banerjee, R; Bhattacharyya, A; Lahiri, S; Mandal, AK; Roy, S; Samaddar, S | 1 |
| BRITTON, HG | 1 |
| CHAKRABARTY, AN; GOVIL, KK; GUPTA, NP; GUPTA, SP | 1 |
| CERBON, J; TRUJILLO, A | 1 |
| FUTTERMAN, S; KINOSHITA, JH; MEROLA, LO; SATOH, K | 1 |
| JENSOVSKY, L; KOCOUREK, J; KOSTIR, J; TICHA, M | 1 |
| KOCWA, E | 1 |
| PIRIE, A; VANHEYNINGEN, R | 1 |
| DALPOZZO, A | 2 |
| PIRIE, A | 1 |
| Gräub, R; Hilti, N; Niederberger, C; Schweingruber, ME | 1 |
| Cejková, J; Krane, J; Midelfart, A; Risa, O; Saether, O | 1 |
| Battaglia, FC; Burton, GJ; Hempstock, J; Jauniaux, E; Teng, C | 1 |
| Berenbaum, MR; Zangerl, AR | 1 |
| Akagi, S; Chugh, SS; Danesh, FR; Kanwar, YS; Nayak, B; Sun, L; Thakur, A; Wada, J; Xie, P; Yang, Q | 1 |
| Yamauchi, A | 1 |
| Arvindakshan, M; Chen, YS; Chung, SK; Chung, SS; Ellery, CA; Ho, EC; Lam, KS; Oates, PJ; Yagihashi, S; Yamagishi, S; Yip, JC | 1 |
| Bennett, AB; Deguchi, M; Kanahama, K; Kanayama, Y; Yamada, K; Yamaki, S | 1 |
| Beck, FX; Neuhofer, W | 1 |
| Colinet, H; Gagneul, D; Kostál, V; Lalouette, L; Renault, D | 1 |
| Leuschner, RG; Murray, BS; Portner, DC | 1 |
| Gao, P; Lu, X; Shi, XZ; Xu, GW; Yuan, KL | 1 |
| Chong, L; Diamond, DM; Hanna, S; Malone, JI; Mervis, RF; Park, CR; Saporta, S | 1 |
| Cooper, TG; Junaidi, A; Setyawan, EE; Widiasih, DA; Yeung, CH | 1 |
| Arroyo, JA; Battaglia, FC; Galan, HL; Teng, C | 1 |
| Battaglia, FC; de Vrijer, B; Galan, HL; Regnault, TR; Teng, C; Wilkening, RB | 1 |
| Arroyo, JA; Battaglia, FC; Galan, HL; Garcia-Jones, P; Graham, A; Teng, CC | 1 |
| Hidalgo, K; Khodayari, S; Larvor, V; Moharramipour, S; Renault, D | 1 |
| Ahmad, F; Bano, Z; Hassan, MI; Islam, A; Khan, S; Singh, LR | 1 |
| Jackson-Atogi, R; Rösgen, J; Sinha, PK | 1 |
| Leandro, MJ; Loureiro-Dias, MC; Madeira, A; Pereira, I; Prista, C | 1 |
| Arroyo, JA; Galan, HL; Lee, GT; Mejia, CA; Price, MD | 1 |
| Ali, S; Begley, P; Cooper, GJ; Dowsey, AW; Dunn, WB; Freeman, OJ; Gardiner, NJ; Hollywood, KA; Petersen, RS; Rustogi, N; Unwin, RD | 1 |
| Ahmad, F; Dar, MA; Hassan, MI; Islam, A | 2 |
| Al-Attar, R; Storey, KB; Zhang, Y | 1 |
| Aa, JY; Ding, F; Gao, HX; He, J; Sun, RB; Wang, GJ; Wang, JK; Xie, Y; Yang, N; Zeng, CH; Zhang, JW; Zhu, XD | 1 |
| Cho, M; Kossowska, D; Kwak, K | 1 |
| Akagi, S; Ejiri, K; Fuke, S; Hata, Y; Ito, H; Kawai, Y; Kihara, H; Minagawa, T; Miyoshi, T; Nagano, T; Nakamura, K; Nakamura, Y; Nanba, S; Nishii, N; Sakuragi, S; Takaishi, A; Toda, H; Yoshikawa, M | 1 |
| Akagi, S; Ejiri, K; Fuke, S; Hata, Y; Ito, H; Kawai, Y; Kihara, H; Minagawa, T; Miyoshi, T; Nagano, T; Nakamura, K; Nakamura, Y; Namba, S; Nishii, N; Sakuragi, S; Takaishi, A; Toda, H; Yoshikawa, M | 1 |
| Dang, R; Guo, J; Han, W; Li, Y; Meng, J; Si, Q; Wang, S; Wei, N; Wu, L; Xie, D | 1 |
30 review(s) available for inositol and sorbitol
| Article | Year |
|---|---|
[Diabetic microangiopathies].
Topics: Basement Membrane; Blood Viscosity; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Diphosphoglyceric Acids; Glycolysis; Growth Hormone; Hemoglobins; Hemostasis; Humans; Hypoxia; Inositol; Insulin; Oxygen Consumption; Peptide Biosynthesis; Platelet Aggregation; Sorbitol; Vasodilation | 1978 |
Diabetic peripheral neuropathy.
Topics: Diabetic Neuropathies; Humans; Inositol; Sorbitol | 1991 |
[Diabetic neuropathy--a review of pathological studies].
Topics: Adolescent; Adult; Aged; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Humans; Inositol; Middle Aged; Peripheral Nerves; Rats; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1991 |
Renal medullary organic osmolytes.
Topics: Animals; Betaine; Glycerylphosphorylcholine; Humans; Inositol; Kidney Medulla; Osmolar Concentration; Sorbitol; Taurine | 1991 |
Regulation of the predominant renal medullary organic solutes in vivo.
Topics: Animals; Betaine; Biological Transport; Diuresis; Glycerylphosphorylcholine; Inositol; Kidney; Kidney Medulla; Osmosis; Sorbitol; Tissue Distribution | 1990 |
Importance of organic osmolytes for osmoregulation by renal medullary cells.
Topics: Alcohols; Amino Acids; Animals; Betaine; Diuresis; Glycerylphosphorylcholine; Humans; Inositol; Kidney Medulla; Methylamines; Sorbitol; Water-Electrolyte Balance | 1990 |
Axonal transport of choline acetyltransferase and 6-phosphofructokinase activities in genetically diabetic mice.
Topics: Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Female; Fructose; Inositol; Mice; Mice, Inbred C57BL; Phosphofructokinase-1; Sorbitol | 1988 |
Pathogenesis of diabetic neuropathy: role of altered phosphoinositide metabolism.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Humans; Inositol; Neural Conduction; Peripheral Nerves; Phosphatidylinositols; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1989 |
Are disturbances of sorbitol, phosphoinositide, and Na+-K+-ATPase regulation involved in pathogenesis of diabetic neuropathy?
Topics: Animals; Diabetic Neuropathies; Glucose; Humans; Inositol; Neural Conduction; Peripheral Nerves; Phosphatidylinositols; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1988 |
Biochemical alterations and complications in diabetes.
Topics: Biological Transport; Diabetes Complications; Diabetes Mellitus; Energy Metabolism; Glucose; Humans; Inositol; Neural Conduction; Peripheral Nerves; Phosphatidylinositols; Protein Kinase C; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1986 |
Sorbitol, myo-inositol and sodium-potassium ATPase in diabetic peripheral nerve.
Topics: Animals; Blood Glucose; Diabetic Neuropathies; Energy Metabolism; Humans; Inositol; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1986 |
Sorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications.
Topics: Animals; Diabetes Complications; Humans; Inositol; Phosphatidylinositols; Protein Kinase C; Rats; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1987 |
Altered sorbitol and myo-inositol metabolism as the basis for defective protein kinase C and (Na,K)-ATPase regulation in diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Inositol; Peripheral Nerves; Protein Kinase C; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1986 |
Osmotically active organic solutes in the renal inner medulla.
Topics: Amino Acids; Animals; Electrolytes; Glycerylphosphorylcholine; Humans; Inositol; Kidney Medulla; Osmolar Concentration; Sorbitol | 1987 |
[Pathogenesis of diabetic neuropathies].
Topics: Animals; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Neuropathies; Energy Metabolism; Humans; Inositol; Ischemia; Nerve Net; Neuritis; Peripheral Nerves; Polyneuropathies; Sorbitol; Time Factors | 1985 |
Galactose cataract: a review.
Topics: Age Factors; Alcohol Oxidoreductases; Aminoisobutyric Acids; Animals; Cataract; Dairy Products; Galactose; Galactosemias; Glucose; Humans; Inositol; Lens, Crystalline; Milk; Milk, Human; Osmosis; Phospholipids; Rabbits; Rats; Sorbitol; Sugar Alcohols; Xylose | 1971 |
Defects of axonal transport in diabetes mellitus--a possible contribution to the aetiology of diabetic neuropathy.
Topics: Animals; Axonal Transport; Body Temperature; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glucose; Humans; Hyperglycemia; Inositol; Neurons; Sorbitol | 1984 |
[Metabolic alterations and diabetic complications (author's transl)].
Topics: Biological Transport, Active; Blood Glucose; Diabetes Mellitus; Diabetic Ketoacidosis; Hemoglobins; Humans; Inositol; Insulin; Sorbitol | 1980 |
Mechanisms of pathogenesis in diabetes mellitus.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Histocompatibility Testing; Humans; Inositol; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Obesity; Receptor, Insulin; Risk Factors; Sorbitol | 1995 |
Molecular basis of osmotic regulation.
Topics: Aldehyde Reductase; Animals; Betaine; Biological Transport; Carrier Proteins; Gene Expression; Glycerylphosphorylcholine; Humans; Inositol; Kidney; Kidney Medulla; Membrane Glycoproteins; Membrane Transport Proteins; Models, Biological; Models, Structural; Osmolar Concentration; Protein Structure, Secondary; Sodium Chloride; Sorbitol; Taurine; Urea; Water-Electrolyte Balance | 1995 |
Molecular basis for osmoregulation of organic osmolytes in renal medullary cells.
Topics: Animals; Betaine; Cell Division; Cell Survival; Cells, Cultured; Inositol; Kidney Medulla; Phosphatidylcholines; Sorbitol; Taurine; Water-Electrolyte Balance | 1994 |
Organic osmolytes in the kidney.
Topics: Aldehyde Reductase; Animals; Betaine; Cells, Cultured; Diuresis; Glycerylphosphorylcholine; Humans; Inositol; Kidney; Kidney Concentrating Ability; Osmolar Concentration; Sorbitol; Taurine | 1993 |
[Osmolytes and osmoregulation in renal cells].
Topics: Adaptation, Physiological; Animals; Betaine; Cells, Cultured; Glycerylphosphorylcholine; Inositol; Kidney; Osmolar Concentration; Sorbitol; Taurine; Water-Electrolyte Balance | 1996 |
Kidney cell survival in high tonicity.
Topics: Animals; Betaine; Biological Transport, Active; Cell Survival; Glycerylphosphorylcholine; Humans; Inositol; Kidney Concentrating Ability; Kidney Medulla; Signal Transduction; Sorbitol; Taurine; Water-Electrolyte Balance | 1997 |
[Contemporary views on the pathogenesis of diabetic neuropathy].
Topics: Adenosine Triphosphatases; Basement Membrane; Diabetic Neuropathies; Endothelium, Vascular; Free Radicals; Humans; Inositol; Neural Conduction; Risk Factors; Sorbitol | 1998 |
Introduction to cell volume regulatory mechanisms.
Topics: Amino Acids; Animals; Betaine; Cell Size; Glycerylphosphorylcholine; Humans; Inositol; Ion Channels; Ion Transport; Membrane Potentials; Osmosis; Osmotic Pressure; Sorbitol; Taurine | 1998 |
Mechanisms of osmolyte release.
Topics: Animals; Betaine; Calcium Signaling; Cell Membrane Permeability; Cell Polarity; Diabetes Mellitus; Glycerylphosphorylcholine; Humans; Hypotonic Solutions; Inositol; Ion Channel Gating; Ion Channels; Ion Transport; Kidney Tubules, Collecting; Loop of Henle; Osmotic Pressure; Rabbits; Rats; Sorbitol; Taurine | 1998 |
Cellular osmoregulation in kidney medulla.
Topics: Amino Acids; Animals; Betaine; Diuresis; Glycerylphosphorylcholine; Heat-Shock Proteins; Humans; Inositol; Kidney Medulla; Mammals; Natriuresis; Osmotic Pressure; Sodium Chloride; Sodium-Potassium-Exchanging ATPase; Sorbitol; Stress, Physiological; Urea; Water-Electrolyte Balance | 1998 |
[Molecular mechanism in biological transport in the kidney: Osmolyte transporter].
Topics: Animals; Betaine; Biological Transport; Carrier Proteins; GABA Plasma Membrane Transport Proteins; Gene Expression Regulation; Glycerylphosphorylcholine; Heat-Shock Proteins; Humans; Inositol; Kidney Medulla; Membrane Proteins; Osmolar Concentration; Sorbitol; Symporters; Taurine; Transcription Factors; Transcription, Genetic | 2006 |
Cell volume regulation in the renal papilla.
Topics: Adaptation, Physiological; Animals; Betaine; Carrier Proteins; Cell Size; Cell Survival; Cells, Cultured; Extracellular Space; GABA Plasma Membrane Transport Proteins; Inositol; Kidney Medulla; Kidney Tubules, Collecting; Osmotic Pressure; Rats; Sorbitol; Water-Electrolyte Balance | 2006 |
6 trial(s) available for inositol and sorbitol
| Article | Year |
|---|---|
The effect of aldose reductase inhibition on erythrocyte polyols and galactitol accumulation in diabetic patients.
Topics: Aldehyde Reductase; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Double-Blind Method; Erythrocytes; Galactitol; Humans; Hypoglycemic Agents; Inositol; Phthalazines; Pyridazines; Sorbitol; Sugar Alcohol Dehydrogenases; Sugar Alcohols | 1989 |
The penetration of Sorbinil, an aldose reductase inhibitor, into lens, aqueous humour and erythrocytes of patients undergoing cataract extraction.
Topics: Aged; Aldehyde Reductase; Aqueous Humor; Cataract Extraction; Chromatography, High Pressure Liquid; Diabetes Mellitus; Erythrocytes; Female; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; Middle Aged; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
myo-Inositol and sorbitol in erythrocytes from diabetic patients before and after sorbinil treatment.
Topics: Adult; Aldehyde Reductase; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Double-Blind Method; Erythrocytes; Female; Gas Chromatography-Mass Spectrometry; Humans; Imidazoles; Imidazolidines; Inositol; Male; Middle Aged; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
Effect of aldose reductase inhibitors on glucose-induced changes in sorbitol and myo-inositol metabolism in human neutrophils.
Topics: Adult; Aldehyde Reductase; Enzyme Inhibitors; Humans; Imidazoles; Imidazolidines; Inositol; Linear Models; Male; Neutrophils; Reference Values; Rhodanine; Sorbitol; Thiazolidines | 1999 |
Effect of Luseogliflozin on Heart Failure With Preserved Ejection Fraction in Patients With Diabetes Mellitus.
Topics: Aged; Biomarkers; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Heart Failure; Humans; Hypoglycemic Agents; Inositol; Male; Middle Aged; Natriuretic Peptide, Brain; Prospective Studies; Sodium-Glucose Transporter 2 Inhibitors; Sorbitol; Stroke Volume | 2020 |
Effects of luseogliflozin and voglibose on high-risk lipid profiles and inflammatory markers in diabetes patients with heart failure.
Topics: Adiponectin; Biomarkers; C-Reactive Protein; Cholesterol, LDL; Diabetes Mellitus, Type 2; Glucose; Heart Failure; Humans; Inositol; Malondialdehyde; Sodium; Sorbitol | 2022 |
307 other study(ies) available for inositol and sorbitol
| Article | Year |
|---|---|
Inhibition of human acrosin by monosaccharides and related compounds: structure-activity relationships.
Topics: Acrosin; Humans; In Vitro Techniques; Kinetics; Male; Molecular Conformation; Monosaccharides; Protease Inhibitors; Spermatozoa; Structure-Activity Relationship | 1981 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Cellular zwitterionic metabolite analogs simultaneously enhance reaction rate, thermostability, salt tolerance, and substrate specificity of α-glucosidase.
Topics: alpha-Glucosidases; Betaine; Enzyme Stability; Ions; Kinetics; Models, Molecular; Protein Conformation; Saccharomyces cerevisiae; Salt Tolerance; Substrate Specificity; Temperature | 2011 |
Implications of aldose reductase in cataracts in human diabetes.
Topics: Aldehyde Reductase; Blood Glucose; Cataract; Diabetes Mellitus; Fructose; Glucose; Humans; Inositol; Lens, Crystalline; Quercetin; Sorbitol; Sugar Alcohol Dehydrogenases | 1979 |
The localisation of sorbitol pathway activity in the rat renal cortex and its relationship to the pathogenesis of the renal complications of diabetes mellitus.
Topics: Animals; Chromatography, Gas; Diabetes Mellitus; Diabetic Nephropathies; Fructose; Glucose; Inositol; Kidney Cortex; Kidney Glomerulus; Kidney Medulla; Kidney Tubules; Male; Rats; Sorbitol; Streptozocin; Sugar Alcohols | 1975 |
The effect of an unsaturated-fat diet on cataract formation in streptozotocin-induced diabetic rats.
Topics: Animals; Aqueous Humor; Carbohydrate Metabolism; Cataract; Diabetes Mellitus; Dietary Fats; Eye; Fats, Unsaturated; Hexoses; Inositol; Lens, Crystalline; Lipid Metabolism; Liver; Male; Oils; Rats; Retina; Sorbitol; Streptozocin; Zea mays | 1976 |
Effect of experimental diabetes and insulin onphosphatidyl-inositol synthesis in rat sciatic nerve.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Galactitol; Galactose; Glucose; Inositol; Insulin; Male; Peripheral Nerves; Phosphatidylinositols; Rats; Sorbitol; Streptozocin | 1979 |
[Free carbohydrate content of the cortex and nucleus of bovine lenses as a function of ageing (author's transl)].
Topics: Age Factors; Animals; Ascorbic Acid; Carbohydrate Metabolism; Cattle; Chromatography, Gas; Fructose; Glucose; Inositol; Lens, Crystalline; Rabbits; Rats; Sorbitol | 1977 |
Initial changes in the free carbohydrate profile of rat lens and retina following streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Fructose; Glucose; Inositol; Kinetics; Lens, Crystalline; Monosaccharides; Rats; Retina; Sorbitol | 1979 |
Cyclical changes in the carbohydrate composition of dog endometrium.
Topics: Animals; Carbohydrates; Dogs; Endometrium; Estrus; Female; Fructose; Glucose; Glucuronates; Inositol; Pregnancy; Sorbitol | 1979 |
Does myo-inositol specifically interact with brain microtubules?
Topics: Animals; Brain; Glucose; Inositol; Inositol Phosphates; Microtubules; Protein Binding; Sheep; Sorbitol; Tubulin | 1978 |
Polyol permeability of the human red cell. Interpretation of glucose transport in terms of a pore.
Topics: Binding, Competitive; Biological Transport; Biological Transport, Active; Blood Glucose; Cell Membrane Permeability; Erythritol; Erythrocyte Membrane; Erythrocytes; Humans; Inositol; Kinetics; Mannitol; Mathematics; Models, Biological; Sorbitol; Sugar Alcohols | 1977 |
Gas chromatographic separation and mass spectrometric identification of polyols in human cerebrospinal fluid and plasma.
Topics: Chromatography, Gas; Erythritol; Humans; Inositol; Mannitol; Mass Spectrometry; Sorbitol; Sugar Alcohols | 1977 |
Polyols in the cerebrospinal fluid and plasma of neurological, diabetic and uraemic patients.
Topics: Diabetes Mellitus; Humans; Inositol; Ischemic Attack, Transient; Kidney Failure, Chronic; Mannitol; Meningitis, Viral; Sorbitol; Sugar Alcohols | 1977 |
Cerebrospinal fluid sorbitol and myoinositol in diabetic polyneuropathy.
Topics: Adult; Aged; Blood Glucose; Diabetic Neuropathies; Dietary Carbohydrates; Humans; Hypoglycemic Agents; Inositol; Insulin; Middle Aged; Neural Conduction; Sorbitol; Time Factors | 1977 |
Stimulation of the gerbil's gustatory receptors by polyols.
Topics: Animals; Chemoreceptor Cells; Erythritol; Ethylene Glycols; Evoked Potentials; Gerbillinae; Glycerol; Inositol; Isomerism; Kinetics; Male; Mannitol; Sorbitol; Structure-Activity Relationship; Sucrose; Sugar Alcohols; Taste; Xylitol | 1976 |
Quantitatively minor areas of metabolism of both sugar alcohols and sugars.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus; Glucosamine; Glucose; Inositol; Sorbitol; Sugar Alcohols | 1976 |
Myo-inositol transport in the central nervous system.
Topics: Animals; Ascorbic Acid; Biological Transport, Active; Brain; Carbon Radioisotopes; Choroid Plexus; Chromatography, Paper; Glucose; In Vitro Techniques; Infusions, Parenteral; Inositol; Inulin; Kinetics; Mannitol; Probenecid; Rabbits; Sorbitol; Thiourea; Time Factors; Tritium | 1975 |
Sorbitol and other polyols in lens, adipose tissue and urine in diabetes mellitus.
Topics: Adipose Tissue; Cataract; Chromatography, Gas; Diabetes Mellitus; Fructose; Glucose; Humans; Inositol; Lens, Crystalline; Monosaccharides; Pentoses; Sorbitol; Sugar Alcohols | 1975 |
Variation in polyol levels in cerebrospinal fluid and serum in diabetic patients.
Topics: Aged; Blood Glucose; Creatinine; Deoxyglucose; Diabetes Mellitus; Diabetic Nephropathies; Ethers, Cyclic; Glucose; Humans; Inositol; Insulin; Middle Aged; Sorbitol; Sugar Alcohols; Uremia | 1975 |
Effect of a prostaglandin I2 derivative (iloprost) on peripheral neuropathy of diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Iloprost; Inositol; Male; Neural Conduction; Protein Kinases; Rats; Rats, Wistar; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1992 |
Inhibition of phosphatidylinositol synthase by glucose in human retinal pigment epithelial cells.
Topics: Aldehyde Reductase; CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase; Culture Media; Glucose; Humans; Inositol; Membrane Proteins; Osmolar Concentration; Phosphatidylinositols; Phosphorus; Phosphotransferases; Pigment Epithelium of Eye; Sorbitol; Transferases (Other Substituted Phosphate Groups) | 1992 |
A combination of the aldose reductase inhibitor, statil, and the prostaglandin E1 analogue, OP1206.alpha CD, completely improves sciatic motor nerve conduction velocity in streptozocin-induced chronically diabetic rats.
Topics: Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hypoglycemic Agents; Inositol; Male; Neural Conduction; Phthalazines; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1992 |
Effects of a new aldose reductase inhibitor, (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-ca rboxamid e (SNK-860), on the slowing of motor nerve conduction velocity and metabolic abnormalities in the peripheral nerve in acute streptozo
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Streptozocin | 1992 |
Myocardial inositol and sodium in diabetes.
Topics: Animals; Biopsy; Body Fluid Compartments; Chromatography, Gas; Diabetes Mellitus, Experimental; Disease Models, Animal; Dogs; Evaluation Studies as Topic; Hemodynamics; Inositol; Intracellular Fluid; Male; Myocardium; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol; Tissue Distribution | 1992 |
Glycosylation of proteins and microangiopathy.
Topics: Albuminuria; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diglycerides; Dogs; Glomerular Mesangium; Glycolysis; Glycosylation; Guanidines; Humans; Inositol; Rats; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1992 |
The role of cyclic adenosine 3',5'-monophosphate and polyol metabolism in diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Chalcone; Chalcones; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Iloprost; Inositol; Male; Neural Conduction; Rats; Rats, Inbred WKY; Rhodanine; Sciatic Nerve; Sorbitol; Thiazolidines | 1992 |
Depletion of substance P and calcitonin gene-related peptide in sciatic nerve of rats with experimental diabetes; effects of insulin and aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Fluorenes; Fructose; Glucose; Hydantoins; Inositol; Insulin; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Substance P | 1992 |
Aldose reductase and myo-inositol in endothelial cell dysfunction caused by elevated glucose.
Topics: Acetylcholine; Aldehyde Reductase; Animals; Endothelium, Vascular; Glucose; Inositol; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Rabbits; Sorbitol | 1992 |
Increase in cardiac muscle fructose content in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Gas Chromatography-Mass Spectrometry; Inositol; L-Iditol 2-Dehydrogenase; Male; Papillary Muscles; Rats; Rats, Sprague-Dawley; Sorbitol; Streptozocin | 1992 |
Effects of aminoguanidine on peripheral nerve function and polyol pathway metabolites in streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Glycation End Products, Advanced; Guanidines; Inositol; Male; Neural Conduction; Peripheral Nerves; Polymers; Rats; Rats, Sprague-Dawley; Sorbitol; Streptozocin | 1992 |
Modulation of myo-[3H]inositol uptake by glucose and sorbitol in cultured bovine lens epithelial cells. I. Restoration of myo-inositol uptake by aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Biological Transport; Cattle; Cells, Cultured; Deoxyglucose; Epithelium; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Meglumine; Sodium; Sorbitol | 1992 |
Modulation of myo-[3H]inositol uptake by glucose and sorbitol in cultured bovine lens epithelial cells. II. Characterization of high- and low-affinity myo-inositol transport sites.
Topics: Aldehyde Reductase; Animals; Binding Sites; Biological Transport; Cattle; Cells, Cultured; Epithelium; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Lens, Crystalline; Sorbitol | 1992 |
Renal sorbitol, myo-inositol and glycerophosphorylcholine in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Blood Proteins; Body Weight; Creatinine; Diabetes Mellitus, Experimental; Diuresis; Glycerylphosphorylcholine; Glycosuria; Inositol; Insulin; Kidney; Male; Osmolar Concentration; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sorbitol | 1992 |
Myo-inositol transport in the lens of galactose-maintained rats.
Topics: Animals; Biological Transport, Active; Carbohydrate Metabolism; Cataract; Cell Membrane Permeability; Chromatography, Gas; Galactose; Inositol; Lens, Crystalline; Male; Polymers; Rats; Rats, Inbred Strains; Sorbitol | 1992 |
Metabolic abnormalities of the hyperglycemic obese Zucker rat.
Topics: Animals; Fructose; Glucose; Glycosuria; Hyperglycemia; Inositol; Male; Obesity; Rats; Rats, Zucker; Sorbitol | 1992 |
Amelioration of nerve Na(+)-K(+)-ATPase activity independently of myo-inositol level by PGE1 analogue OP-1206.alpha-CD in streptozocin-induced diabetic rats.
Topics: Alprostadil; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Inositol; Male; Motor Neurons; Nerve Fibers, Myelinated; Neural Conduction; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Reference Values; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1991 |
Osmotically regulated taurine content in rat renal inner medulla.
Topics: Amino Acids; Animals; Aspartic Acid; Betaine; Glycerylphosphorylcholine; Hypotonic Solutions; Inositol; Kidney Medulla; Male; Osmolar Concentration; Rats; Rats, Inbred Strains; Saline Solution, Hypertonic; Sodium Chloride; Sorbitol; Taurine; Water-Electrolyte Balance | 1991 |
Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: prevention of dysmorphogenesis with aldose reductase inhibitors and myo-inositol.
Topics: Aldehyde Reductase; Animals; Blood; Congenital Abnormalities; Culture Media; Culture Techniques; Female; Fetus; Glucose; Hyperglycemia; Inositol; Morphogenesis; Pregnancy; Rats; Rats, Inbred Strains; Sorbitol | 1991 |
Distribution and regulation of organic osmolytes along the nephron.
Topics: Animals; Betaine; Glycerylphosphorylcholine; In Vitro Techniques; Inositol; Nephrons; Osmolar Concentration; Rats; Rats, Inbred Strains; Sorbitol | 1991 |
Resting membrane potential in 41A3 mouse neuroblastoma cells. Effect of increased glucose and galactose concentrations.
Topics: Animals; Galactose; Glucose; Indicators and Reagents; Inositol; Kinetics; Membrane Potentials; Mice; Neuroblastoma; Neurons; Onium Compounds; Organophosphorus Compounds; Ouabain; Potassium; Sodium-Potassium-Exchanging ATPase; Sorbitol; Tumor Cells, Cultured; Veratridine | 1991 |
Adenosine triphosphatase activity in sciatic nerve tissue of streptozocin-induced diabetic rats with and without high dietary sucrose: effect of aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sucrose | 1991 |
[Diabetic neuropathy--pathogenesis and precipitating factors].
Topics: Alcohol Drinking; Animals; Diabetic Neuropathies; Energy Metabolism; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Risk Factors; Smoking; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1991 |
Effect of vanadate on renal hypertrophy and sorbitol accumulation in streptozotocin induced diabetes in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Hypertrophy; Inositol; Kidney; Male; Organ Size; Rats; Rats, Inbred Strains; Sorbitol; Vanadates | 1991 |
Intracellular betaine substitutes for sorbitol in protecting renal medullary cells from hypertonicity.
Topics: Aldehyde Reductase; Animals; Betaine; Cell Division; Cell Line; Cell Survival; Clone Cells; Glycerylphosphorylcholine; Inositol; Kidney Medulla; Naphthalenes; Rabbits; Saline Solution, Hypertonic; Sorbitol | 1991 |
The role of polyols in cerebral cell volume regulation in hypernatremic and hyponatremic states.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Brain; Electrolytes; Hypernatremia; Hyponatremia; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Vasopressins; Water-Electrolyte Balance | 1991 |
Polyol pathway in tissues of spontaneously diabetic Chinese hamsters (Cricetulus griseus) and the effect of an aldose reductase inhibitor, ONO-2235.
Topics: Aldehyde Reductase; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Female; Fructose; Inositol; Kidney; Lens, Crystalline; Male; Polymers; Retina; Rhodanine; Sciatic Nerve; Sorbitol; Thiazolidines | 1991 |
Sorbitol, myo-inositol, and rod outer segment phagocytosis in cultured hRPE cells exposed to glucose. In vitro model of myo-inositol depletion hypothesis of diabetic complications.
Topics: Adult; Aldehyde Reductase; Cells, Cultured; Diabetic Retinopathy; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Middle Aged; Phagocytosis; Pigment Epithelium of Eye; Rod Cell Outer Segment; Sorbitol | 1991 |
[Diabetic complication].
Topics: Aldehyde Reductase; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetic Nephropathies; Diabetic Neuropathies; Glycosylation; Humans; Inositol; Proteins; Rhodanine; Sorbitol; Thiazolidines | 1991 |
Polyol determination along the rat nephron.
Topics: Animals; Dissection; Inositol; Kidney Cortex; Kidney Medulla; Kidney Tubules; Luminescent Measurements; Male; Microchemistry; Nephrons; Rats; Rats, Inbred Strains; Sorbitol; Tissue Distribution | 1990 |
Effects of islet isografts on hemodynamic and vascular filtration changes in diabetic rats.
Topics: Animals; Blood Pressure; Diabetes Mellitus, Experimental; Glomerular Filtration Rate; Hemodynamics; Inositol; Iodine Radioisotopes; Islets of Langerhans; Islets of Langerhans Transplantation; Kidney; Male; Pancreas Transplantation; Rats; Rats, Inbred Lew; Regional Blood Flow; Serum Albumin, Bovine; Sorbitol; Transplantation, Isogeneic | 1990 |
Effect of fructose supplementation on sorbitol accumulation and myo-inositol metabolism in cultured neuroblastoma cells exposed to increased glucose concentrations.
Topics: Aldehyde Reductase; Animals; Biological Transport; Cell Line; Cycloheximide; Fructose; Glucose; Inositol; Kinetics; Mice; Neuroblastoma; Phospholipids; Sorbitol | 1990 |
Polyol pathway and fetal malformations: a search for the right mode of prevention.
Topics: Aldehyde Reductase; Animals; Congenital Abnormalities; Female; Fetal Diseases; Glucose; Inositol; Pregnancy; Pregnancy in Diabetics; Rats; Sorbitol | 1990 |
Effects of hyperglycaemia on sorbitol and myo-inositol contents of cultured embryos: treatment with aldose reductase inhibitor and myo-inositol supplementation.
Topics: Aldehyde Reductase; Animals; Embryo, Mammalian; Embryonic and Fetal Development; Female; Fetal Diseases; Glucose; Hyperglycemia; Inositol; Rats; Rats, Inbred Strains; Sorbitol | 1990 |
The significance of nerve sugar levels for the peripheral nerve impairment of spontaneously diabetic GK (Goto-Kakizaki) rats.
Topics: Aging; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Fructose; Glucose; Inositol; Male; Motor Neurons; Neural Conduction; Rats; Rats, Inbred Strains; Reference Values; Sciatic Nerve; Sorbitol | 1990 |
Nonosmotic diabetic cataracts.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases; Taurine | 1990 |
Effects of long-term aldose reductase inhibition on development of experimental diabetic neuropathy. Ultrastructural and morphometric studies of sural nerve in streptozocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Male; Nerve Fibers; Nerve Fibers, Myelinated; Neural Conduction; Rats; Rats, Inbred Strains; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases; Sural Nerve; Time Factors | 1990 |
Correction of altered metabolic activities in sciatic nerves of streptozocin-induced diabetic rats. Effect of ganglioside treatment.
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Gangliosides; Inositol; Male; Myelin Proteins; Ouabain; Phosphatidylinositols; Phospholipids; Rats; Rats, Inbred Strains; Reference Values; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1990 |
[Alterations in the sorbitol pathway and Na(+)-K(+)-ATPase activity of peripheral nerve of alloxan-induced diabetic rats].
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glucose; Inositol; Male; Ouabain; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1990 |
Diabetes and the myo-inositol paradox.
Topics: Animals; Aqueous Humor; Blood Glucose; Cornea; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Inositol; Kidney; Myocardium; Rabbits; Reference Values; Retina; Sorbitol | 1990 |
Modulation of osmolytes in MDCK cells by solutes, inhibitors, and vasopressin.
Topics: Animals; Cell Line; Glucose; Glycerylphosphorylcholine; Imidazoles; Imidazolidines; Inositol; Kidney; Phlorhizin; Sodium Chloride; Sorbitol; Vasopressins; Water-Electrolyte Balance | 1990 |
Factors affecting the ratio of different organic osmolytes in renal medullary cells.
Topics: Animals; Betaine; Cell Line; Culture Media; Glycerylphosphorylcholine; Hypertonic Solutions; Inositol; Kidney Medulla; Osmolar Concentration; Sodium Chloride; Sorbitol; Urea | 1990 |
Glucose-induced dysmorphogenesis in the cultured rat conceptus: prevention by supplementation with myo-inositol.
Topics: Animals; Congenital Abnormalities; Culture Media; Culture Techniques; Disease Models, Animal; Embryo, Mammalian; Female; Glucose; Humans; Hyperglycemia; Inositol; Pregnancy; Pregnancy in Diabetics; Rats; Rats, Inbred Strains; Sorbitol | 1990 |
Regulation and localization of organic osmolytes in mammalian kidney.
Topics: Animals; Betaine; Diabetes Insipidus; Diabetes Mellitus, Experimental; Glycerylphosphorylcholine; Inositol; Kidney; Methylamines; Polymers; Rats; Rats, Brattleboro; Sorbitol; Water-Electrolyte Balance | 1990 |
Modulation of hemodynamic and vascular filtration changes in diabetic rats by dietary myo-inositol.
Topics: Animals; Diabetes Mellitus, Experimental; Diet; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Hemodynamics; Inositol; Iodine Radioisotopes; Kidney; Male; Proteinuria; Rats; Rats, Inbred Strains; Regional Blood Flow; Serum Albumin, Bovine; Sorbitol | 1990 |
Osmoregulation of betaine transport in mammalian renal medullary cells.
Topics: Animals; Betaine; Biological Transport; Cell Line; Glycerylphosphorylcholine; Hypertonic Solutions; Inositol; Kidney Medulla; Osmolar Concentration; Sodium Chloride; Sorbitol; Water-Electrolyte Balance | 1990 |
Effects of hypernatremia on organic brain osmoles.
Topics: Acute Disease; Amino Acids; Animals; Body Water; Brain; Chronic Disease; Hypernatremia; Inositol; Magnetic Resonance Spectroscopy; Male; Osmolar Concentration; Rats; Rats, Inbred Strains; Reference Values; Sodium; Sorbitol; Urea | 1990 |
Reversal of deficits in axonal transport and nerve conduction velocity by treatment of streptozotocin-diabetic rats with myo-inositol.
Topics: Administration, Oral; Animals; Axonal Transport; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Inositol; Male; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Streptozocin; Time Factors | 1985 |
Slow component-a of axonal transport, nerve myo-inositol, and aldose reductase inhibition in streptozocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Diabetes Mellitus, Experimental; Fructose; Ganglia, Spinal; Glucose; Inositol; Male; Neurons; Phthalazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
A sodium-pump defect in diabetic peripheral nerve corrected by sorbinil administration: relationship to myo-inositol metabolism and nerve conduction slowing.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Energy Metabolism; Humans; Imidazoles; Imidazolidines; Inositol; Ion Channels; Neural Conduction; Peripheral Nerves; Rats; Rats, Inbred BB; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1986 |
Studies of sorbinil on axonal transport in streptozotocin-diabetic rats.
Topics: Animals; Axonal Transport; Blood Glucose; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Male; Phospholipids; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol | 1986 |
Studies on in vivo inactivation of gramicidin S synthetase and its retardation.
Topics: 2,4-Dinitrophenol; Amino Acid Isomerases; Bacillus; Bacterial Proteins; Cysteine; Dinitrophenols; Dithiothreitol; Energy Metabolism; Fructose; Glucose; Glycerol; Gramicidin; Half-Life; Inositol; Multienzyme Complexes; Oxidation-Reduction; Peptide Synthases; Sorbitol; Time Factors | 1986 |
Fast anterograde axonal transport in wasted and non-wasted diabetic rats; effects of aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Body Temperature; Diabetes Mellitus, Experimental; Fructose; Inositol; Insulin; Male; Motor Neurons; Muscles; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Defects of axonal transport in experimental diabetes that are unrelated to the sorbitol pathway.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Peripheral Nerves; Phosphofructokinase-1; Rats; Rats, Inbred Strains; Sorbitol | 1987 |
Treatment with an aldose reductase inhibitor can reduce the susceptibility of fast axonal transport following nerve compression in the streptozotocin-diabetic rat.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Female; Inositol; Nerve Compression Syndromes; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1987 |
Studies on peripheral nerve and lens in long-term experimental diabetes: effects of the aldose reductase inhibitor statil.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Body Weight; Carbohydrates; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Ileum; Inositol; Lens, Crystalline; Male; Muscles; Neural Conduction; Peripheral Nerves; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases | 1988 |
Essential fatty acid treatment--effects on nerve conduction, polyol pathway and axonal transport in streptozotocin diabetic rats.
Topics: Animals; Axonal Transport; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fatty Acids, Essential; Fructose; gamma-Linolenic Acid; Glucose; Hypolipidemic Agents; Inositol; Linoleic Acids; Male; Motor Neurons; Neural Conduction; Oenothera biennis; Plant Oils; Rats; Rats, Inbred Strains; Reference Values; Sciatic Nerve; Sorbitol | 1989 |
The effect of elevated glucose levels on myo-inositol metabolism in cultured bovine aortic endothelial cells.
Topics: Aldehyde Reductase; Animals; Aorta; Cattle; Cell Membrane; Cells, Cultured; Endothelium, Vascular; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Phospholipids; Sorbitol | 1989 |
Ascorbic acid metabolism and polyol pathway in diabetes.
Topics: Aldehyde Reductase; Animals; Ascorbic Acid; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Female; Galactose; Inositol; Kidney Cortex; Kidney Medulla; Naphthalenes; Rats; Rats, Inbred Strains; Reference Values; Sorbitol | 1989 |
Effects of aldose reductase inhibitor sorbinil on neuroaxonal dystrophy and levels of myo-inositol and sorbitol in sympathetic autonomic ganglia of streptozocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactose; Ganglia, Sympathetic; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases | 1989 |
The effects of 5% and 25% galactose diets on lens polyols, glutathione and protein glycation in male and female pigs.
Topics: Animals; Cataract; Chromatography, Gas; Chromatography, High Pressure Liquid; Diet; Female; Galactitol; Galactose; Glutathione; Inositol; Lens, Crystalline; Lysine; Male; Sex Factors; Sorbitol; Sugar Alcohols; Swine; Time Factors | 1989 |
Rapid analysis of sorbitol, galactitol, mannitol and myoinositol mixtures from biological sources.
Topics: Animals; Chromatography, Gas; Erythrocytes; Galactitol; Gas Chromatography-Mass Spectrometry; Inositol; Mannitol; Rats; Retina; Sciatic Nerve; Sorbitol; Sugar Alcohols | 1989 |
Acute regulation of the predominant organic solutes of the rabbit renal inner medulla.
Topics: Animals; Betaine; Diuresis; Furosemide; Glycerylphosphorylcholine; Homeostasis; Inositol; Kidney Medulla; Magnetic Resonance Spectroscopy; Male; Mannitol; Phosphorus; Rabbits; Sodium; Sorbitol; Urea; Vasopressins | 1989 |
Lens hexitols and cataract formation during lactation in a woman heterozygote for galactosaemia.
Topics: Adult; Cataract; Female; Galactitol; Galactokinase; Galactosemias; Genetic Carrier Screening; Humans; Inositol; Lactation; Lens, Crystalline; Male; Pregnancy; Pregnancy Complications; Reference Values; Sorbitol; Sugar Alcohols | 1989 |
The effect of aldose reductase inhibition on the pattern of nerve conduction deficits in diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Kinetics; Male; Muscles; Neural Conduction; Peroneal Nerve; Phthalazines; Pyridazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1989 |
A novel sorbitol transport mechanism in cultured renal papillary epithelial cells.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Cell Line; Diuretics; Epithelium; Galactitol; Inositol; Kidney Medulla; Kinetics; Mannitol; Osmolar Concentration; Pancreatitis-Associated Proteins; Radioisotope Dilution Technique; Sorbitol; Sucrose | 1989 |
Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electrophysiology; Inositol; Lactates; Male; Myelin Sheath; Nerve Fibers; Phosphocreatine; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1989 |
Differential regulation of protein kinase C and (Na,K)-adenosine triphosphatase activities by elevated glucose levels in retinal capillary endothelial cells.
Topics: Aldehyde Reductase; Animals; Capillaries; Cattle; Endothelium, Vascular; Glucose; Inositol; Ouabain; Protein Kinase C; Retina; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1989 |
Attenuation of phosphoinositidase activity and phosphatidylinositol bisphosphate level of bovine retinal capillary pericytes in high glucose.
Topics: 1-Phosphatidylinositol 4-Kinase; Aldehyde Reductase; Animals; Capillaries; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Fluorenes; Glucose; Hydantoins; Inositol; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphotransferases; Retinal Vessels; Sorbitol | 1989 |
[Abnormal inositol phospholipid metabolism as a main factor causing pericyte drop-out in diabetic retinopathy].
Topics: Aldehyde Reductase; Animals; Cattle; Cell Line; Diabetic Retinopathy; Glucose; Imidazoles; Imidazolidines; Inositol; Phosphatidylinositols; Sorbitol | 1989 |
Effect of antidiuretic hormone on renal organic osmolytes in Brattleboro rats.
Topics: Animals; Drinking; Glycerylphosphorylcholine; Inositol; Kidney; Male; Rats; Rats, Brattleboro; Rats, Inbred Strains; Rats, Mutant Strains; Sorbitol; Tissue Distribution; Urine; Vasopressins | 1989 |
[Recent advances in the pathogenesis of diabetic neuropathy].
Topics: Animals; Axons; Diabetic Neuropathies; Humans; Inositol; Phosphocreatine; Sorbitol | 1989 |
Methylamine and polyol responses to salt loading in renal inner medulla.
Topics: Animals; Betaine; Hypernatremia; Inositol; Kidney Medulla; Male; Methylamines; Rats; Rats, Inbred Strains; Reference Values; Sodium; Sodium Chloride; Sorbitol; Sugar Alcohols | 1989 |
Two-step high-performance liquid chromatography method for the determination of myo-inositol and sorbitol.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Female; Fructose; Inositol; Kidney Glomerulus; Rats; Rats, Inbred Strains; Sorbitol | 1989 |
The effect of high glucose on polyol pathway activity and myoinositol metabolism in cultured human endothelial cells.
Topics: Cells, Cultured; Endothelium, Vascular; Glucose; Humans; Inositol; Kinetics; L-Lactate Dehydrogenase; Sorbitol; Umbilical Veins | 1989 |
Polyols and myo-inositol in diabetic neuropathy--of mice and men.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Galactitol; Inositol; Mice; Peripheral Nerves; Rats; Sorbitol | 1989 |
Nerve glucose, sorbitol, fructose, and myo-inositol at various time after feeding in streptozotocin-induced diabetes in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Food; Fructose; Glucose; Hexoses; Inositol; Male; Peroneal Nerve; Rats; Rats, Inbred Strains; Sorbitol; Time Factors | 1989 |
Organic solute profiles and transport in the rat renal medulla.
Topics: Animals; Betaine; Biological Transport; Diabetes Mellitus, Experimental; Glycerylphosphorylcholine; In Vitro Techniques; Inositol; Kidney Medulla; Male; Polyethylene Glycols; Rats; Rats, Inbred Strains; Sorbitol | 1989 |
Distribution of major organic osmolytes in rabbit kidneys in diuresis and antidiuresis.
Topics: Animals; Betaine; Diuresis; Glycerylphosphorylcholine; Inositol; Kidney; Kidney Cortex; Kidney Medulla; Methylamines; Osmolar Concentration; Rabbits; Sorbitol | 1989 |
Na+-K+-ATPase pumping activity is not directly linked to myo-inositol levels after sorbinil treatment in lenses of diabetic rats.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glutathione; Imidazoles; Imidazolidines; Inositol; Kinetics; Lens, Crystalline; Male; Ouabain; Rats; Rats, Inbred Strains; Rubidium; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases | 1987 |
Effect of a new aldose reductase inhibitor, 8'-chloro-2',3'-dihydrospiro [pyrrolidine-3,6'(5'H)-pyrrolo[1,2,3-de] [1,4]benzoxazine]-2,5,5'- trione (ADN-138), on delayed motor nerve conduction velocity in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Motor Neurons; Neural Conduction; Oxazines; Pyrroles; Rats; Rats, Inbred Strains; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases | 1988 |
Pathways for organic osmolyte synthesis in rabbit renal papillary tissue, a metabolic study using 13C-labeled substrates.
Topics: Alanine; Aldehyde Reductase; Animals; Citric Acid Cycle; Glucose; Glutamates; Glutamic Acid; Glutamine; Glycerylphosphorylcholine; Glycolysis; Inositol; Kidney Medulla; Lactates; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Osmolar Concentration; Pyruvates; Pyruvic Acid; Rabbits; Sorbitol | 1988 |
Pathogenesis of diabetic neuropathy.
Topics: Diabetic Neuropathies; Humans; Inositol; Peripheral Nerves; Sorbitol | 1989 |
Regulation of organic osmolyte concentrations in tubules from rat renal inner medulla.
Topics: Animals; Glycerylphosphorylcholine; In Vitro Techniques; Inositol; Kidney Medulla; Kidney Tubules; L-Lactate Dehydrogenase; Male; Osmosis; Rats; Rats, Inbred Strains; Sorbitol | 1989 |
Experimental chronic hypoxic neuropathy: relevance to diabetic neuropathy.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Electrophysiology; Glycated Hemoglobin; Hexokinase; Hypoxia; Inositol; Lactates; Lactic Acid; Male; Mathematics; Neural Conduction; Nucleosides; Oxygen Consumption; Phosphofructokinase-1; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol | 1986 |
Axonal transport and nerve conduction velocity in animal models of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Motor Neurons; Neural Conduction; Rats; Sorbitol | 1985 |
Recent advances in the therapy of diabetic peripheral neuropathy by means of an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Biological Transport; Diabetic Neuropathies; Humans; Imidazoles; Imidazolidines; Inositol; Neural Conduction; Peripheral Nerves; Peripheral Nervous System Diseases; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Experimental diabetes mellitus impairs the function of the retinal pigmented epithelium.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Glucose; Imidazoles; Imidazolidines; Inositol; Pigment Epithelium of Eye; Rabbits; Rats; Retina; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1986 |
Aldose reductase inhibition, glomerular metabolism, and diabetic nephropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Imidazoles; Imidazolidines; Inositol; Kidney Glomerulus; Rats; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
The polyol pathway in dysfunction of diabetic peripheral nerve.
Topics: Aldehyde Reductase; Animals; Diabetic Neuropathies; Humans; Inositol; Neural Conduction; Peripheral Nerves; Rats; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1985 |
Role of sorbitol accumulation and myo-inositol depletion in paranodal swelling of large myelinated nerve fibers in the insulin-deficient spontaneously diabetic bio-breeding rat. Reversal by insulin replacement, an aldose reductase inhibitor, and myo-inosi
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Electrophysiology; Inositol; Insulin; Male; Nerve Fibers, Myelinated; Neuromuscular Junction; Rats; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohol Dehydrogenases | 1987 |
Osmotic effectors in kidneys of xeric and mesic rodents: corticomedullary distributions and changes with water availability.
Topics: Animals; Arvicolinae; Diuresis; Inositol; Kidney Cortex; Kidney Medulla; Methylamines; Osmolar Concentration; Peromyscus; Potassium; Rodentia; Sodium; Sorbitol; Urea; Water-Electrolyte Balance | 1988 |
Prevention of neural myoinositol depletion in diabetic rats by aldose reductase inhibition with tolrestat.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose; Inositol; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1986 |
Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesis.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Congenital Abnormalities; Culture Techniques; Female; Fetus; Inositol; Pregnancy; Pregnancy in Diabetics; Rats; Sorbitol | 1986 |
myo-Inositol metabolism in 41A3 neuroblastoma cells: effects of high glucose and sorbitol levels.
Topics: Animals; Cell Division; Cell Line; Choline; Ethanolamine; Ethanolamines; Glucose; Inositol; Kinetics; Mice; Neuroblastoma; Phosphatidylinositols; Serine; Sorbitol | 1987 |
Development of potent aldose reductase inhibitors having a hydantoin structure.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Hydantoins; Inositol; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Structure-Activity Relationship; Sugar Alcohol Dehydrogenases | 1987 |
Prolonged fructose feeding and aldose reductase inhibition: effect on the polyol pathway in kidneys of normal rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Dietary Carbohydrates; Fructose; Glucose; Inositol; Kidney; L-Iditol 2-Dehydrogenase; Male; Naphthalenes; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases | 1987 |
Statil-sensitive polyol formation in nerve of galactose-fed mice.
Topics: Aldehyde Reductase; Animals; Carbohydrates; Diabetes Mellitus, Experimental; Galactitol; Galactose; Inositol; Mice; Mice, Inbred C57BL; Peripheral Nerves; Phthalazines; Pyridazines; Sorbitol; Sugar Alcohol Dehydrogenases; Sugar Alcohols | 1988 |
Effect of aldose reductase inhibition on nerve conduction velocity and resistance to ischemic conduction block in experimental diabetes.
Topics: Action Potentials; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Inositol; Insulin; Ischemia; Kinetics; Male; Neural Conduction; Phthalazines; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Tail | 1988 |
Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy.
Topics: Adolescent; Adult; Aged; Aldehyde Reductase; Diabetes Mellitus; Diabetic Neuropathies; Erythrocytes; Female; Fructose; Glucose; Humans; Imidazoles; Imidazolidines; Inositol; Male; Middle Aged; Myelin Sheath; Nerve Regeneration; Nerve Tissue; Sorbitol; Sural Nerve | 1988 |
Increased nerve polyol levels in experimental diabetes and their reversal by Sorbinil.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Time Factors | 1988 |
Motor nerve conduction velocity and nerve polyols in mice with short-term genetic or streptozotocin-induced diabetes.
Topics: Acute Disease; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Female; Fructose; Glucose; Inositol; Male; Mice; Mice, Inbred C57BL; Neural Conduction; Sciatic Nerve; Sorbitol; Streptozocin; Time Factors | 1985 |
Analysis of sorbitol, galactitol, and myo-inositol in lens and sciatic nerve by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Galactitol; Galactosemias; Inositol; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohols | 1988 |
Methylcobalamin improves nerve conduction in streptozotocin-diabetic rats without affecting sorbitol and myo-inositol contents of sciatic nerve.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Inositol; Male; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Vitamin B 12 | 1988 |
Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cells, Cultured; Cerebrovascular Circulation; Diabetes Mellitus, Experimental; Endothelium, Vascular; Glucose; Inositol; Male; Microcirculation; Rabbits; Rats; Rats, Inbred Strains; Reference Values; Sorbitol | 1988 |
A new prostaglandin E1 analogue (TFC-612) prevents a decrease in motor nerve conduction velocity in streptozocin-diabetic rats.
Topics: Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Insulin; Male; Motor Neurons; Neural Conduction; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol | 1988 |
The development of electroretinogram abnormalities and the possible role of polyol pathway activity in diabetic hyperglycemia and galactosemia.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Electroretinography; Galactitol; Galactosemias; Hyperglycemia; Inositol; Insulin; Male; Oxazines; Pyrroles; Rats; Rats, Inbred Strains; Retina; Sorbitol; Sugar Alcohols | 1988 |
Diabetes affects sorbitol and myo-inositol levels of neuroectodermal tissue during embryogenesis in rat.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Body Weight; Creatine; Diabetes Mellitus, Experimental; Ectoderm; Embryo, Mammalian; Energy Metabolism; Female; Gestational Age; Glucose; Histocytochemistry; Inositol; Litter Size; Malates; Phosphocreatine; Pregnancy; Pregnancy in Diabetics; Rats; Rats, Inbred Strains; Sorbitol | 1988 |
Effect of sorbinil on myo-inositol metabolism in cultured neuroblastoma cells exposed to increased glucose levels.
Topics: Animals; Cell Line; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Kinetics; Mice; Neuroblastoma; Sorbitol; Tumor Cells, Cultured | 1988 |
Effect of acute and chronic hypernatremia on myoinositol and sorbitol concentration in rat brain and kidney.
Topics: Acute Disease; Animals; Body Water; Brain; Chronic Disease; Hypernatremia; Inositol; Kidney; Male; Osmolar Concentration; Rats; Rats, Inbred Strains; Sorbitol | 1988 |
Changes in sorbitol, myo-inositol and lipid inositol in dorsal root and sympathetic ganglia from streptozotocin-diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Fructose; Ganglia, Spinal; Ganglia, Sympathetic; Inositol; Lipid Metabolism; Male; Rats; Rats, Inbred Strains; Sorbitol | 1986 |
Peripheral nerve concentrations of glucose, fructose, sorbitol and myoinositol in diabetic and non-diabetic patients.
Topics: Adult; Aged; Aged, 80 and over; Carbohydrate Metabolism; Diabetes Mellitus; Female; Fructose; Glucose; Humans; Inositol; Male; Middle Aged; Peripheral Nerves; Sorbitol | 1987 |
[Effect of trapidil on neuropathy in diabetic mice].
Topics: Animals; Blood Glucose; Cholesterol, HDL; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Lipids; Mice; Mice, Inbred C57BL; Neural Conduction; Peripheral Nerves; Pyrimidines; Sorbitol; Trapidil | 1986 |
Reversal of diabetic cataract by sorbinil, an aldose reductase inhibitor.
Topics: Aldehyde Reductase; Animals; Cataract; Diabetes Mellitus, Experimental; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Microscopy, Electron, Scanning; Rats; Rats, Inbred Strains; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Electrophysiology; Imidazoles; Imidazolidines; Inositol; Male; Pigment Epithelium of Eye; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1985 |
Sex steroid dependency of diabetes-induced changes in polyol metabolism, vascular permeability, and collagen cross-linking.
Topics: Animals; Blood Glucose; Capillary Permeability; Collagen; Diabetes Mellitus, Experimental; Female; Gonadal Steroid Hormones; Humans; Inositol; Insulin-Like Growth Factor I; Male; Orchiectomy; Rats; Rats, Inbred Strains; Sorbitol | 1986 |
Altered retinal metabolism in diabetes. I. Microanalysis of lipid, glucose, sorbitol, and myo-inositol in the choroid and in the individual layers of the rabbit retina.
Topics: Animals; Choroid Plexus; Diabetes Mellitus, Experimental; Glucose; Inositol; Ischemia; Lipids; Male; Microchemistry; Rabbits; Retina; Sorbitol; Vitreous Body | 1986 |
Diabetes-induced increases in vascular permeability and changes in granulation tissue levels of sorbitol, myo-inositol, chiro-inositol, and scyllo-inositol are prevented by sorbinil.
Topics: Adolescent; Animals; Capillary Permeability; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Granulation Tissue; Humans; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sorbitol; Stereoisomerism | 1986 |
The cerebrospinal fluid in uncontrolled diabetes mellitus.
Topics: Adolescent; Adult; Aged; Alcohol Oxidoreductases; Blood Glucose; Diabetes Mellitus; Diabetic Ketoacidosis; Female; Fructose; Glucose; Humans; Inositol; Insulin; Male; Middle Aged; Osmolar Concentration; Potassium; Sodium; Sorbitol; Spinal Puncture; Sugar Alcohols | 1973 |
Polyol metabolism in monkey-kidney epithelial-cell cultures. Sorbitol synthesis.
Topics: Animals; Cells, Cultured; Epithelial Cells; Epithelium; Fructose; Glucose; Haplorhini; Inositol; Kidney Cortex; Lactates; Sorbitol; Species Specificity; Sugar Alcohols | 1974 |
[Effect of a series of nonelectrolytes on the activity of Na, K-ATPase].
Topics: Adenosine Triphosphatases; Animals; Glycerol; Guinea Pigs; In Vitro Techniques; Inositol; Kidney Cortex; Monosaccharides; Ouabain; Phenols; Phlorhizin; Potassium; Sodium; Sorbitol; Thymol | 1973 |
Sorbitol metabolism in the retina: accumulation of pathway intermediates in streptozotocin induced diabetes in the rat.
Topics: Animals; Aqueous Humor; Blood Glucose; Chromatography, Gas; Diabetes Mellitus; Fatty Acids, Nonesterified; Fructose; Glucose; Inositol; Lens, Crystalline; Male; Rats; Retina; Sorbitol; Streptozocin | 1974 |
The structure of triphosphoinositide from beef brain.
Topics: Animals; Brain Chemistry; Cattle; Chromatography, Paper; Electrophoresis; Inositol; Phosphatidylinositols; Sorbitol | 1966 |
Behavior of cycloaldolase from Neurospora crassa towards substrate analogs and aldolase inhibitors.
Topics: Carbohydrate Epimerases; Chemical Phenomena; Chemistry; Edetic Acid; Fructose-Bisphosphate Aldolase; Fructosephosphates; Glucosephosphate Dehydrogenase; Glucosephosphates; Hexosephosphates; Inositol; Kinetics; Mannose; NAD; Neurospora; Neurospora crassa; Pentosephosphates; Phosphates; Pyridoxal; Pyridoxamine; Ribose; Schiff Bases; Sorbitol; Structure-Activity Relationship | 1972 |
Secretion of free glucose and related carbohydrates in the male accessory organs of rodents.
Topics: Animals; Chromatography, Paper; Fructose; Genitalia, Male; Glucose; Guinea Pigs; Inositol; Male; Mice; Neuraminic Acids; Prostate; Rats; Rodentia; Seminal Vesicles; Sorbitol; Species Specificity | 1971 |
The function of the suspending medium during the freeze-drying preservation of Escherichia coli.
Topics: Dextrans; Escherichia coli; Freeze Drying; Glucose; Inositol; Mannitol; Methods; Sorbitol; Suspensions | 1973 |
Fermentative and serological studies on Propionibacterium acnes.
Topics: Absorption; Agglutination Tests; Animals; Antigens, Bacterial; Bacteriological Techniques; Culture Media; Fermentation; Immune Sera; Immunodiffusion; Inositol; Maltose; Mannitol; Propionibacterium; Rabbits; Serotyping; Sorbitol | 1973 |
Enhancement of x-ray damage in synchronous Chinese hamster cells by hypertonic treatments.
Topics: Animals; Cell Nucleus; Cell Survival; Cells, Cultured; Chromosome Aberrations; Cricetinae; Culture Media; Female; Glucose; Hypertonic Solutions; Inositol; Microscopy, Electron; Mitosis; Osmolar Concentration; Ovary; Potassium Chloride; Radiation Effects; Radiation-Sensitizing Agents; Sodium Chloride; Sorbitol; Time Factors | 1972 |
Monosaccharides and polyols in diabetes mellitus and uremia.
Topics: Adult; Aged; Blood Glucose; Chromatography, Gas; Diabetes Mellitus; Female; Fructose; Humans; Inositol; Male; Mannose; Middle Aged; Monosaccharides; Sorbitol; Sugar Alcohols; Uremia | 1973 |
[Analysis of glucides in golden hamster male accessory glands].
Topics: Animals; Carbohydrate Metabolism; Chromatography, Paper; Cricetinae; Fermentation; Fructose; Glucose; Inositol; Male; Neuraminic Acids; Prostate; Seminal Vesicles; Sorbitol; Spectrum Analysis; Testis | 1969 |
[Presence of myoinositol monoacetate in Campanula. Detection of L-inositol scylliton, mannitol and sorbitol in some botanical groups].
Topics: Acetates; Inositol; Mannitol; Methods; Plants; Sorbitol | 1970 |
Hyperglycemia, polyol accumulation, and increased intracranial pressure.
Topics: Animals; Brain; Brain Edema; Cerebrospinal Fluid Proteins; Diabetic Ketoacidosis; Disease Models, Animal; Dogs; Fructose; Glucose; Humans; Hyperglycemia; Inositol; Intracranial Pressure; Mannitol; Osmolar Concentration; Sorbitol; Water-Electrolyte Balance | 1971 |
Sorbitol pathway in the ciliary body in relation to accumulation of amino acids in the aqueous humor of alloxan-diabetic rabbits.
Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Aqueous Humor; Ciliary Body; Diabetes Mellitus, Experimental; Epithelial Cells; Epithelium; Fructose; Glucose; Inositol; Lens, Crystalline; Rabbits; Retina; Sorbitol | 1971 |
Polyol oxidoreductase activity in human blood serum during acute hepatitis.
Topics: Acute Disease; Alcohol Oxidoreductases; Aspartate Aminotransferases; Carbohydrates; Electrophoresis; Erythritol; Glycerol; Hepatitis; Humans; Inositol; Liver; Liver Cirrhosis; Mannitol; Sorbitol; Time Factors; Xylitol | 1971 |
Permeability of pea chloroplasts to alcohols and aldoses as measured by reflection coefficients.
Topics: Alcohols; Arabinose; Chemical Phenomena; Chemistry, Physical; Chloroplasts; Erythritol; Galactose; Glucose; Glycerol; Glycols; Hexoses; Inositol; Kinetics; Mannitol; Mannose; Mathematics; Methanol; Osmotic Pressure; Pentoses; Permeability; Plant Cells; Plants; Sorbitol; Stereoisomerism; Sucrose; Sugar Alcohols; Thermodynamics; Xylose | 1971 |
Two classes of pleiotropic mutants of Aerobacter aerogenes lacking components of a phosphoenolpyruvate-dependent phosphotransferase system.
Topics: Alcohols; Animals; Arabinose; Behavior, Animal; Biological Transport, Active; Carbon Isotopes; Enterobacter; Fructose; Galactose; Glucose; Glycerol; Inositol; Mannitol; Mannose; Models, Theoretical; Molecular Biology; Mutation; Phosphotransferases; Pyruvates; Ribose; Sorbitol | 1967 |
Glycosidases of the crystalline lens. I. Effect of pH, inhibitors, and distribution in various areas of the lens and in subcellular fractions.
Topics: Acetates; Animals; Aqueous Humor; Chondroitin; Digitalis Glycosides; Enzymes; Ergocalciferols; Fluorometry; Fructose; Fucose; Galactosamine; Galactosidases; Glucosamine; Glucosidases; Glucuronates; Glycoside Hydrolases; Heparin; Hexosaminidases; Humans; Hydrogen-Ion Concentration; Inositol; Lens, Crystalline; Mannose; Rabbits; Rats; Sodium; Sorbitol; Steroids; Subcellular Fractions; Sulfates; Surface-Active Agents; Urea; Vitamin A | 1971 |
Studies on the permeability of rat liver lysosomes to carbohydrates.
Topics: Animals; Carbohydrate Metabolism; Disaccharides; Gluconates; Glucosidases; Glucuronates; In Vitro Techniques; Inositol; Lactates; Liver; Lysosomes; Male; Maltose; Mannitol; Monosaccharides; Permeability; Rats; Sorbitol; Sulfatases | 1969 |
[In vitro chemical hydrolysis of inositol, mannitol and sorbitol hexanicotinates].
Topics: Absorption; Chemistry, Pharmaceutical; Hydrogen-Ion Concentration; Inositol; Mannitol; Nicotinic Acids; Sorbitol | 1969 |
Urinary sugars and sugar alcohols.
Topics: Alcohols; Carbohydrates; Chromatography, Gas; Chromatography, Ion Exchange; Glycosuria; Humans; Infant, Newborn; Inositol; Lactose; Mannitol; Sorbitol | 1970 |
The relative permeability of lysosomes from Tetrahymena pyriformis to carbohydrates, lactate and the cryoprotective nonelectrolytes glycerol and dimethylsulphoxide.
Topics: Acid Phosphatase; Animals; Carbohydrate Metabolism; Dimethyl Sulfoxide; Disaccharides; Galactose; Gluconates; Glucosamine; Glucose; Glucuronates; Glycerol; Hexoses; Inositol; Lactates; Lysosomes; Maltose; Mannitol; Oligosaccharides; Permeability; Sorbitol; Sucrose; Tetrahymena | 1970 |
[A study of the enzymatic activity of cultures of Sh. flexneri].
Topics: Arabinose; Carbohydrate Metabolism; Glucose; Inositol; Maltose; Mannitol; Rhamnose; Shigella; Sorbitol; Xylose | 1967 |
[Biochemical characteristics of the cataract lens. 1. Comparison of water content and concentration of sorbitol, inositol, glutathione and sialic acid in the young and adult rat lens].
Topics: Aging; Animals; Cataract; Glutathione; Inositol; Lens, Crystalline; Neuraminic Acids; Rats; Sorbitol; Water | 1967 |
Occurrence and determination of inositol in the oviducts of turkey and hen.
Topics: Animals; Chickens; Chromatography, Gas; Female; Fructose; Glucose; Inositol; Male; Oviducts; Semen; Silicones; Sorbitol; Spermatozoa; Turkeys | 1969 |
Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Glucose; In Vitro Techniques; Inositol; Peripheral Nerves; Rats; Sorbitol; Spinal Cord | 1966 |
The placental transfer of hexoses and polyols in the guinea-pig, as shown by umbilical perfusion of the placenta.
Topics: Alcohols; Animals; Blood Glucose; Chromatography; Erythritol; Female; Galactose; Guinea Pigs; Inositol; Maternal-Fetal Exchange; Perfusion; Phloretin; Pregnancy; Propiophenones; Sorbitol | 1966 |
D-mannitol, erythritol and glycerol in bovine semen.
Topics: Alcohols; Animals; Cattle; Chromatography, Paper; Erythritol; Glycerol; Inositol; Male; Mannitol; Semen; Sorbitol | 1967 |
Solubilization of glucose and related sugars by lecithin.
Topics: Arabinose; Cholesterol; Galactose; Glucose; Inositol; Lactones; Phosphatidylcholines; Solubility; Sorbitol; Starch; Sucrose; Thermodynamics | 1967 |
The chromatography of ninhydrin negative compounds on an amino acid analyzer column.
Topics: Acetates; Alcohols; Autoanalysis; Chromatography; Cyanides; Fatty Acids; Formates; Fumarates; Hexosephosphates; Hexoses; Indicators and Reagents; Inositol; Lactates; Pyruvates; Sorbitol; Succinates; Sucrose; Sulfates; Tritium; Urea | 1967 |
Utilization of alcohols by some anthracnose fungi.
Topics: Alcohols; Chromatography, Paper; Culture Media; Ethanol; Fungi; Glycerol; Glycols; Inositol; Mannitol; Methanol; Sorbitol | 1967 |
Carbohydrate metabolism in the sheep placenta.
Topics: Alcohols; Animals; Carbohydrate Metabolism; Carbon Isotopes; Female; Fructose; Glucose; Glycerol; Inositol; Maternal-Fetal Exchange; Perfusion; Placenta; Pregnancy; Pregnancy, Animal; Sheep; Sorbitol; Umbilical Cord | 1967 |
Prevention of defects of axonal transport and nerve conduction velocity by oral administration of myo-inositol or an aldose reductase inhibitor in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Inositol; Male; Motor Neurons; Neural Conduction; Quinolines; Quinolones; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases | 1983 |
Prevention and reversal of defective axonal transport and motor nerve conduction velocity in rats with experimental diabetes by treatment with the aldose reductase inhibitor Sorbinil.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol | 1984 |
Slow orthograde axonal transport of radiolabelled protein in sciatic motoneurones of rats with short-term experimental diabetes: effects of treatment with an aldose reductase inhibitor or myo-inositol.
Topics: Aldehyde Reductase; Animals; Axonal Transport; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Inositol; Male; Motor Neurons; Phthalazines; Proline; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
Studies on diabetic cataract in rats induced by streptozotocin. II. Biochemical examinations of rat lenses in relation to cataract stages.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Fructose; Inositol; Lens, Crystalline; Male; Potassium; Rats; Rats, Inbred Strains; Sodium; Sorbitol; Streptozocin; Water | 1983 |
Polyol pathway activity and myo-inositol metabolism. A suggested relationship in the pathogenesis of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohols | 1983 |
Myo-inositol and sorbitol metabolism in relation to peripheral nerve function in experimental diabetes in the rat: the effect of aldose reductase inhibition.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Peripheral Nerves; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1983 |
Glomerular polyol accumulation in diabetes and its prevention by oral sorbinil.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Imidazoles; Imidazolidines; Inositol; Kidney Glomerulus; Male; Proteins; Rats; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
Stable isotope dilution analysis of galactitol in amniotic fluid: an accurate approach to the prenatal diagnosis of galactosemia.
Topics: Amniotic Fluid; Female; Galactitol; Galactosemias; Gas Chromatography-Mass Spectrometry; Humans; Inositol; Mannitol; Pregnancy; Prenatal Diagnosis; Sorbitol; Sugar Alcohols; UTP-Hexose-1-Phosphate Uridylyltransferase | 1984 |
Etiology of cataracts in diabetics.
Topics: Adolescent; Adult; Aldehyde Reductase; Animals; Blood Glucose; Cataract; Child; Child, Preschool; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dogs; Fructose; Glucose; Humans; Inositol; Lens, Crystalline; Middle Aged; Quercetin; Rats; Refractive Errors; Sorbitol | 1984 |
The effects of aldose reductase inhibition on nerve sorbitol and myoinositol concentrations in diabetic and galactosemic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erythrocytes; Female; Galactosemias; Imidazoles; Imidazolidines; Inositol; Peripheral Nerves; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases | 1984 |
Secretory activity of salivary gland slices in the presence of polyols.
Topics: alpha-Amylases; Animals; Cattle; Glucose; Humans; Inositol; Parotid Gland; Peroxidases; Salivary Proteins and Peptides; Sialic Acids; Sorbitol; Submandibular Gland; Sugar Alcohols; Xylitol | 1983 |
Free inositol, sorbitol and fructose levels in sciatic nerve.
Topics: Diabetes Mellitus; Fructose; Humans; Inositol; Reference Values; Sciatic Nerve; Sorbitol | 1983 |
Gas chromatographic analysis of lens monosaccharides.
Topics: Animals; Chromatography, Gas; Fructose; Glucose; Glycerol; Humans; Inositol; Lens, Crystalline; Monosaccharides; Rats; Rodentia; Sorbitol | 1984 |
Analysis of carbohydrates in lens, erythrocytes, and plasma by high-performance liquid chromatography of nitrobenzoate derivatives.
Topics: Animals; Carbohydrates; Chromatography, High Pressure Liquid; Erythrocytes; Glucose; Humans; Inositol; Lens, Crystalline; Nitrobenzoates; Rats; Sorbitol | 1984 |
Polyol pathway metabolites in human cataracts. Correlation of circulating glycosylated hemoglobin content and fasting blood glucose levels.
Topics: Blood Glucose; Carbohydrates; Cataract; Fructose; Glucose; Glycated Hemoglobin; Humans; Inositol; Lens, Crystalline; Sorbitol; Sugar Alcohols | 1984 |
Free and lipid inositol, sorbitol and sugars in sciatic nerve obtained post-mortem from diabetic patients and control subjects.
Topics: Aged; Carbohydrate Metabolism; Diabetes Mellitus; Female; Fructose; Glucose; Humans; Inositol; Lipid Metabolism; Male; Middle Aged; Sciatic Nerve; Sorbitol | 1983 |
Sorbitol, inositol and nerve conduction in diabetes.
Topics: Animals; Diabetes Mellitus; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Mice; Mice, Inbred C57BL; Neural Conduction; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol | 1983 |
Transport of myo-inositol into endoneurial preparations of sciatic nerve from normal and streptozotocin-diabetic rats.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Body Weight; Diabetes Mellitus, Experimental; Fructose; Glucose; In Vitro Techniques; Inositol; Male; Phosphocreatine; Rats; Rats, Inbred Strains; Sciatic Nerve; Sorbitol | 1983 |
Sorbitol and myoinositol levels in the cerebrospinal fluid of diabetic patients.
Topics: Diabetes Mellitus; Humans; Inositol; Reference Values; Sorbitol | 1980 |
[Reactions in the rats from prolonged consumption of lactose or hydrolyzed lactose. 3. Crystalline lens].
Topics: Animals; Cataract; Crystallins; Galactitol; Galactosephosphates; Hydrolysis; Inositol; Lactose; Lens, Crystalline; Male; Rats; Rats, Inbred Strains; Sorbitol; Sucrose; Sugar Alcohols | 1982 |
Human diabetic endoneurial sorbitol, fructose, and myo-inositol related to sural nerve morphometry.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Fructose; Humans; Inositol; Middle Aged; Peripheral Nerves; Sorbitol | 1980 |
[Sugars, polyols and electrolytes in human cataractous lens (author's transl)].
Topics: Aged; Cataract; Glucose; Humans; Inositol; Lens, Crystalline; Middle Aged; Potassium; Sodium; Sorbitol | 1980 |
[African medical plants. I: Characterization of inositol and sorbitol, probable active principles of kinkeliba (Combretum micranthum G.Don)].
Topics: Chromatography, Gas; Inositol; Plants, Medicinal; Senegal; Sorbitol | 1981 |
Elevated glucose levels increase retinal glycolysis and sorbitol pathway metabolism. Implications for diabetic retinopathy.
Topics: Aldehyde Reductase; Animals; Diabetic Retinopathy; Fluorenes; Fructose; Glucose; Glycolysis; Hydantoins; Inositol; Lactates; Male; Oxidation-Reduction; Pyruvates; Pyruvic Acid; Rats; Rats, Sprague-Dawley; Retina; Sorbitol; Spiro Compounds | 1995 |
Effect of a potent new aldose reductase inhibitor, (5-(3-thienyltetrazol-1-yl)acetic acid (TAT), on diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Erythrocytes; Fructose; Glucose; Inositol; Male; Motor Neurons; Neural Conduction; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Reference Values; Regional Blood Flow; Regression Analysis; Sciatic Nerve; Sorbitol; Tail; Tetrazoles; Thiophenes; Time Factors | 1995 |
Regulation of growth factor mRNA levels in the eyes of diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Diabetic Retinopathy; Eye; Fibroblast Growth Factor 2; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Insulin-Like Growth Factor I; Kidney; Lens, Crystalline; Lung; Male; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sorbitol; Streptozocin | 1995 |
Prevention of diabetic vascular dysfunction by guanidines. Inhibition of nitric oxide synthase versus advanced glycation end-product formation.
Topics: Aldehyde Reductase; Amino Acid Oxidoreductases; Animals; Arginine; Benzothiazoles; Blood Pressure; Body Weight; Capillary Permeability; Citrulline; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glycation End Products, Advanced; Guanidines; Imidazoles; Imidazolidines; Inositol; Iodine Radioisotopes; Male; Methylguanidine; Naphthalenes; Nitric Oxide Synthase; omega-N-Methylarginine; Phthalazines; Rats; Rats, Sprague-Dawley; Retina; Sciatic Nerve; Serum Albumin, Bovine; Sorbitol; Thiazoles; Uvea | 1993 |
Capillary gas chromatography combined with ion trap detection for quantitative profiling of polyols in cerebrospinal fluid and plasma.
Topics: Adult; Aged; Chromatography, Gas; Female; Humans; Inositol; Male; Mannitol; Mass Spectrometry; Middle Aged; Reproducibility of Results; Sorbitol; Sugar Alcohols; Xylitol | 1995 |
Organic osmolytes in the kidney of domesticated red deer, Cervus elaphus.
Topics: Alanine; Amino Acids; Animals; Animals, Domestic; Betaine; Deer; Glycerylphosphorylcholine; Glycine; Inositol; Kidney; Kidney Cortex; Kidney Medulla; Osmolar Concentration; Osmosis; Sorbitol; Taurine; Tissue Distribution | 1995 |
Vascular and metabolic factors in the pathogenesis of experimental diabetic neuropathy in mature rats.
Topics: Animals; Diabetic Neuropathies; Fructose; Glucose; Inositol; Male; Neural Conduction; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Sorbitol; Vascular Resistance | 1994 |
Galactosemia produces ARI-preventable nodal changes similar to those of diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Axons; Body Weight; Diabetic Neuropathies; Fructose; Galactitol; Galactose; Galactosemias; Inositol; Microscopy, Electron; Nerve Fibers, Myelinated; Nerve Regeneration; Neural Conduction; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Sural Nerve | 1994 |
Kinetics of myo-inositol transport in rat ocular lens.
Topics: Animals; Biological Transport; Extracellular Space; Inositol; Kinetics; Lens, Crystalline; Male; Membrane Potentials; Phlorhizin; Rats; Rats, Sprague-Dawley; Sodium; Sorbitol | 1995 |
Neural dysfunction and metabolic imbalances in diabetic rats. Prevention by acetyl-L-carnitine.
Topics: Acetylcarnitine; Animals; Ca(2+) Mg(2+)-ATPase; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diglycerides; Inositol; Lipids; Male; Neural Conduction; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1994 |
Osmoregulatory alterations in myo-inositol uptake by bovine lens epithelial cells. Part 4: Induction pattern of Na(+)-myo-inositol cotransporter mRNA under hypertonic conditions denoting an early-onset, interactive, protective mechanism against water stre
Topics: Aldehyde Reductase; Animals; Biological Transport; Blotting, Northern; Carrier Proteins; Cattle; Cells, Cultured; DNA Probes; Epithelium; Heat-Shock Proteins; Hypertonic Solutions; Inositol; Lens, Crystalline; Membrane Proteins; Osmolar Concentration; RNA, Messenger; Sorbitol; Symporters; Water-Electrolyte Balance | 1994 |
Impairment of renal medullary osmolyte accumulation in potassium-depleted rats.
Topics: Animals; Betaine; Diuresis; Glycerylphosphorylcholine; Inositol; Kidney Concentrating Ability; Kidney Medulla; Male; Osmosis; Potassium Deficiency; Rats; Rats, Wistar; Sodium; Sorbitol; Taurine; Water Deprivation | 1994 |
Cellular mechanisms of glucose-induced myo-inositol transport upregulation in rat mesangial cells.
Topics: Aldehyde Reductase; Animals; Biological Transport; Galactose; Glomerular Mesangium; Glucose; In Vitro Techniques; Inositol; Intracellular Membranes; Kinetics; Male; Naphthalenes; Rats; Rats, Sprague-Dawley; Sorbitol; Time Factors; Up-Regulation | 1994 |
Reduced Na+/K+ ATPase transport activity, resting membrane potential, and bradykinin-stimulated phosphatidylinositol synthesis by polyol accumulation in cultured neuroblastoma cells.
Topics: Animals; Bradykinin; Cell Line; Fructose; Galactose; Glucose; Inositol; Kinetics; Mannose; Membrane Potentials; Mice; Neuroblastoma; Phosphatidylinositols; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sugar Alcohols; Tumor Cells, Cultured | 1994 |
Effects of glucose on sorbitol pathway activation, cellular redox, and metabolism of myo-inositol, phosphoinositide, and diacylglycerol in cultured human retinal pigment epithelial cells.
Topics: Aldehyde Reductase; Cells, Cultured; Diglycerides; Glucose; Humans; Inositol; Oxidation-Reduction; Phosphatidylinositols; Pigment Epithelium of Eye; Pyruvates; Pyruvic Acid; Sorbitol | 1994 |
Aldose reductase gene expression and osmotic dysregulation in cultured human retinal pigment epithelial cells.
Topics: Aldehyde Reductase; Blood Glucose; Cell Line; Fructose; Gene Expression; Glucose; Humans; Hyperglycemia; Imidazoles; Imidazolidines; Inositol; Mannitol; Osmolar Concentration; Osmosis; Pigment Epithelium of Eye; Sorbitol; Time Factors; Water-Electrolyte Balance | 1993 |
Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Male; Neural Conduction; Osmolar Concentration; Rats; Rats, Wistar; Sciatic Nerve; Sorbitol; Taurine | 1993 |
Decreased endoneurial fluid electrolytes in normal rat sciatic nerve after aldose reductase inhibition.
Topics: Adenosine Triphosphatases; Aldehyde Reductase; Animals; Body Water; Chlorides; Connective Tissue; Female; Fructose; Glucose; Homeostasis; Inositol; Phthalazines; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sodium; Sodium-Potassium-Exchanging ATPase; Sorbitol | 1993 |
Mechanism and regulation of swelling-activated inositol efflux in brain glial cells.
Topics: Animals; Arachidonic Acid; Biological Transport; Brain; Calcium; Cyclic AMP; Inositol; Intracellular Membranes; Kinetics; Mannitol; Neuroglia; Protein Kinase C; Sodium; Sorbitol; Tumor Cells, Cultured; Water | 1993 |
Effects of high glucose concentrations and epalrestat on sorbitol and myo-inositol metabolism in cultured rabbit aortic smooth muscle cells.
Topics: Aldehyde Reductase; Animals; Aorta; Biological Transport, Active; Cells, Cultured; Cytochalasin B; Dose-Response Relationship, Drug; Fructose; Glucagon; Glucose; Inositol; Insulin; Muscle, Smooth, Vascular; Ouabain; Rabbits; Rhodanine; Sodium; Sorbitol; Thiazolidines | 1993 |
Reversal of hyperglycemic-induced defects in myo-inositol metabolism and Na+/K+ pump activity in cultured neuroblastoma cells by normalizing glucose levels.
Topics: Animals; Biological Transport; Blood Glucose; Galactose; Glucose; Hyperglycemia; Inositol; Neuroblastoma; Osmolar Concentration; Reference Values; Sodium-Potassium-Exchanging ATPase; Sorbitol; Time Factors; Tumor Cells, Cultured | 1993 |
Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture.
Topics: Aldehyde Reductase; Carbachol; CDP-Diacylglycerol-Inositol 3-Phosphatidyltransferase; Cells, Cultured; Diglycerides; Enzyme Induction; Glucose; Humans; In Vitro Techniques; Inositol; Membrane Proteins; Phosphatidylinositols; Pigment Epithelium of Eye; Sorbitol; Transferases (Other Substituted Phosphate Groups) | 1993 |
Sugar alcohols in the lens epithelium of age-related cataract.
Topics: Aged; Blood Glucose; Cataract; Diabetes Mellitus; Epithelium; Female; Humans; Inositol; Lens, Crystalline; Male; Sorbitol | 1993 |
Organic osmolytes in human and other mammalian kidneys.
Topics: Animals; Betaine; Dogs; Glycerylphosphorylcholine; Humans; Inositol; Kidney Medulla; Male; Osmosis; Rabbits; Sorbitol; Species Specificity; Swine | 1993 |
Determinants of relative amounts of medullary organic osmolytes: effects of NaCl and urea differ.
Topics: Animals; Betaine; Blood; Body Water; Glycerylphosphorylcholine; Inositol; Kidney Medulla; Male; Osmolar Concentration; Potassium; Rats; Rats, Wistar; Sodium; Sodium Chloride; Sorbitol; Taurine; Urea | 1993 |
Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats.
Topics: Action Potentials; Animals; Butylated Hydroxytoluene; Capillaries; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Fructose; Hypoxia; Inositol; Male; Motor Neurons; Muscle, Smooth, Vascular; Muscles; Neural Conduction; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol | 1993 |
Natural course of diabetic peripheral neuropathy in spontaneous-onset diabetic Chinese hamsters.
Topics: Aging; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Electrophysiology; Female; Inositol; Male; Motor Neurons; Neural Conduction; Reference Values; Sciatic Nerve; Sorbitol; Tibial Nerve | 1995 |
Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells.
Topics: Base Sequence; Cholinergic Fibers; Cyclic GMP; Diabetic Neuropathies; Glucose; Humans; Inositol; Models, Neurological; Molecular Sequence Data; Neuroblastoma; Nitric Oxide; Nitric Oxide Synthase; Peripheral Nervous System; Protein Kinase C; Sorbitol; Tumor Cells, Cultured | 1996 |
Primary preventive and secondary interventionary effects of acetyl-L-carnitine on diabetic neuropathy in the bio-breeding Worcester rat.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcarnitine; Alprostadil; Animals; Diabetic Neuropathies; Dinoprostone; Fructose; Inositol; Male; Neural Conduction; Rats; Rats, Inbred BB; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Time Factors | 1996 |
Interactions between essential fatty acid, prostanoid, polyol pathway and nitric oxide mechanisms in the neurovascular deficit of diabetic rats.
Topics: Acetanilides; Aldehyde Reductase; Analysis of Variance; Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dietary Fats, Unsaturated; Enzyme Inhibitors; Erythropoietin; Fatty Acids, Essential; Flurbiprofen; Fructose; gamma-Linolenic Acid; Inositol; Linoleic Acids; Male; Neural Conduction; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oenothera biennis; Plant Oils; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Regression Analysis; Sciatic Nerve; Sorbitol; Sulfones | 1996 |
Triglycerides, fatty acids, sterols, mono- and disaccharides and sugar alcohols in human milk and current types of infant formula milk.
Topics: Carbohydrates; Cholesterol; Disaccharides; Fatty Acids; Fatty Acids, Unsaturated; Female; Fucose; Galactose; Glucose; Humans; Infant; Infant Food; Infant, Newborn; Inositol; Milk, Human; Monosaccharides; Netherlands; Sorbitol; Sterols; Sugar Alcohols; Triglycerides | 1996 |
Organic osmolyte distribution and levels in the mammalian urinary bladder in diuresis and antidiuresis.
Topics: Animals; Chromatography, High Pressure Liquid; Diuresis; Epithelium; Inositol; Muscle, Smooth; Osmolar Concentration; Rabbits; Rats; Sorbitol; Urinary Bladder; Urine | 1996 |
Betaine transporter cDNA cloning and effect of osmolytes on its mRNA induction.
Topics: Amino Acid Sequence; Animals; Base Sequence; Betaine; Carrier Proteins; Cell Line; Cloning, Molecular; DNA, Complementary; GABA Plasma Membrane Transport Proteins; Hypertonic Solutions; Inositol; Kidney Medulla; Molecular Sequence Data; Rabbits; RNA, Messenger; Sequence Homology; Sorbitol; Water-Electrolyte Balance | 1996 |
Aldose reductase and myo-inositol transporter mRNA are independently regulated in rat renal medulla.
Topics: Aldehyde Reductase; Animals; Carrier Proteins; Gene Expression Regulation; Inositol; Kidney Cortex; Kidney Medulla; Male; Potassium; Rats; Rats, Wistar; RNA, Messenger; Sodium; Sorbitol; Urea; Urine | 1996 |
Morphophysiologic characterization of peripheral neuropathy in zinc-deficient guinea pigs.
Topics: Animals; Blood Glucose; Body Weight; Brachial Plexus; Carbohydrates; Evoked Potentials, Somatosensory; Female; Fructose; Guinea Pigs; Inositol; Longitudinal Studies; Male; Neural Conduction; Peripheral Nervous System Diseases; Sodium-Potassium-Exchanging ATPase; Sorbitol; Spinal Cord; Zinc | 1996 |
Intrarenal distribution of organic osmolytes in human kidney.
Topics: Animals; Betaine; Chromatography, High Pressure Liquid; Glycerylphosphorylcholine; Humans; Inositol; Kidney; Kidney Medulla; Rats; Rats, Sprague-Dawley; Sorbitol; Tissue Distribution; Water-Electrolyte Balance | 1996 |
Sodium chloride, osmolyte, and osmolarity effects on blastocyst formation in bovine embryos produced by in vitro fertilization (IVF) and cultured in simple serum-free media.
Topics: Animals; Betaine; Blastocyst; Cattle; Culture Media, Serum-Free; Embryonic and Fetal Development; Fertilization in Vitro; Inositol; Osmolar Concentration; Sodium Chloride; Sorbitol; Zygote | 1996 |
Site-specific regulation of organic osmolytes along the rat nephron.
Topics: Animals; Diuretics; Drinking; Furosemide; Inositol; Lithium; Male; Nephrons; Osmolar Concentration; Rats; Rats, Sprague-Dawley; Sorbitol; Urine; Water-Electrolyte Balance | 1996 |
Localization and regulation of renal Na+/myo-inositol cotransporter in diabetic rats.
Topics: 3-O-Methylglucose; Aldehyde Reductase; Animals; Base Sequence; Blood Glucose; Carrier Proteins; Diabetes Mellitus, Experimental; Heat-Shock Proteins; Hypoglycemic Agents; Imidazoles; Imidazolidines; In Situ Hybridization; Inositol; Insulin, Isophane; Kidney Cortex; Kidney Medulla; Loop of Henle; Male; Membrane Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sorbitol; Symporters; Time Factors | 1996 |
Effect of propionyl-L-carnitine on oscillatory potentials in electroretinogram in streptozotocin-diabetic rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Carnitine; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Electroretinography; Fructose; Inositol; Insulin; Lipids; Male; Rats; Rats, Wistar; Retina; Sorbitol; Streptozocin | 1996 |
Renal concentrating defect and organic osmolytes. Paradoxical changes of renal medullary taurine contents in potassium-depleted rats.
Topics: Animals; Betaine; Dehydration; Glycerylphosphorylcholine; Inositol; Kidney Medulla; Male; Potassium; Potassium Deficiency; Rats; Rats, Wistar; Reference Values; Sodium; Sorbitol; Taurine; Urea | 1996 |
Glycerophosphocholine and betaine counteract the effect of urea on pyruvate kinase.
Topics: Animals; Betaine; Glycerylphosphorylcholine; Inositol; Kidney Medulla; Pyruvate Kinase; Sorbitol; Taurine; Urea | 1996 |
Effect of an aldose reductase inhibitor, SNK-860, on deficits in the electroretinogram of diabetic rats.
Topics: Aldehyde Reductase; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Electroretinography; Imidazoles; Imidazolidines; Inositol; Male; Rats; Rats, Sprague-Dawley; Retina; Sorbitol | 1995 |
Comparison of the effects of inhibitors of aldose reductase and sorbitol dehydrogenase on neurovascular function, nerve conduction and tissue polyol pathway metabolites in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Glucose; Inositol; L-Iditol 2-Dehydrogenase; Male; Neural Conduction; Organ Specificity; Peripheral Nerves; Piperazines; Pyrimidines; Rats; Rats, Sprague-Dawley; Sorbitol | 1997 |
Comparison of the effects of Zopolrestat and Sorbinil on lens myo-inositol influx.
Topics: Aldehyde Reductase; Animals; Benzothiazoles; Carbohydrate Metabolism; Carbohydrates; Culture Media; Enzyme Inhibitors; Galactose; Glucose; Imidazoles; Imidazolidines; In Vitro Techniques; Inositol; Lens, Crystalline; Male; Phthalazines; Polymers; Rats; Rats, Sprague-Dawley; Sorbitol; Thiazoles | 1997 |
Genotypic relationships among strains classified under the (Pasteurella) haemolytica-complex as indicated by ribotyping and multilocus enzyme electrophoresis.
Topics: Alleles; alpha-L-Fucosidase; Animals; Arabinose; beta-Galactosidase; Cattle; Deer; DNA, Bacterial; Enzymes; Glucosides; Inositol; Mannheimia haemolytica; Nucleic Acid Hybridization; Ornithine Decarboxylase; Phylogeny; Rabbits; RNA, Ribosomal, 16S; RNA, Ribosomal, 23S; Sheep; Sorbitol; Swine; Xylose; Xylosidases | 1997 |
Depolarized cell growth precedes filamentation during the process of ethanol-induced pseudohyphal formation in the yeast Candida tropicalis.
Topics: Actins; Candida; Cell Division; Chitinases; Ethanol; Inositol; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Sorbitol | 1998 |
Effects of sorbitol dehydrogenase deficiency on nerve conduction in experimental diabetic mice.
Topics: Animals; Brain; Cataract; Diabetes Mellitus, Experimental; Fructose; Glucose; Inositol; Introns; Kidney; Kinetics; L-Iditol 2-Dehydrogenase; Lens, Crystalline; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Neural Conduction; Point Mutation; Sciatic Nerve; Seminal Vesicles; Sheep; Sorbitol; Testis | 1998 |
Normalization of glucose entry under the high glucose condition by phlorizin attenuates the high glucose-induced morphological and functional changes of cultured bovine retinal pericytes.
Topics: Animals; Cattle; Cell Size; Cells, Cultured; DNA; Fructose; Glucose; Inositol; Pericytes; Phlorhizin; Retinal Vessels; Sorbitol; Thymidine | 1999 |
Hypertonicity-induced accumulation of organic osmolytes in papillary interstitial cells.
Topics: Aldehyde Reductase; Amino Acids; Animals; Betaine; Blotting, Northern; Carrier Proteins; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Fibroblasts; GABA Plasma Membrane Transport Proteins; Glycerylphosphorylcholine; Heat-Shock Proteins; Hypertonic Solutions; In Situ Hybridization; Inositol; Kidney Medulla; Kidney Tubules, Collecting; L-Iditol 2-Dehydrogenase; Male; Membrane Proteins; Osmolar Concentration; Rats; Rats, Wistar; RNA, Messenger; Sorbitol; Symporters | 1999 |
The effects of polyols on the thermal stability of calf thymus DNA.
Topics: Animals; Calorimetry, Differential Scanning; Cattle; Circular Dichroism; DNA; Erythritol; Glycerol; Inositol; Mannitol; Molecular Conformation; Nucleic Acid Conformation; Salts; Sorbitol; Sugar Alcohols; Temperature; Thermodynamics; Thymus Gland | 1999 |
Subnormal retinal oxygenation response precedes diabetic-like retinopathy.
Topics: Animals; Blood Glucose; Carbon Dioxide; Diabetic Retinopathy; Fructose; Galactitol; Galactose; Galactosemias; Glucose; Inositol; Magnetic Resonance Imaging; Oxygen; Partial Pressure; Rats; Retina; Sorbitol | 1999 |
An aldose reductase inhibitor prevents the glucose-induced increase in PDGF-beta receptor in cultured rat aortic smooth muscle cells.
Topics: Aldehyde Reductase; Animals; Antibodies; Aorta; Becaplermin; Cells, Cultured; DNA; Enzyme Inhibitors; Fructose; Glucose; Humans; Inositol; Muscle, Smooth, Vascular; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Receptors, Platelet-Derived Growth Factor; Rhodanine; Sorbitol; Thiazolidines | 1999 |
Cilostazol, a cyclic AMP phosphodiesterase inhibitor, stimulates nitric oxide production and sodium potassium adenosine triphosphatase activity in SH-SY5Y human neuroblastoma cells.
Topics: Cilostazol; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dexamethasone; Humans; Inositol; Isoquinolines; Neuroblastoma; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphodiesterase Inhibitors; Sodium-Potassium-Exchanging ATPase; Sorbitol; Sulfonamides; Tetrazoles; Tumor Cells, Cultured | 1999 |
Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Energy Metabolism; Fructose; Ganglia, Spinal; Glucose; Inositol; Male; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Thioctic Acid | 1999 |
Inner-medullary organic osmolytes and inorganic electrolytes in K depletion.
Topics: Amino Acids; Animals; Betaine; Chlorides; Chromatography, High Pressure Liquid; Electrolytes; Electron Probe Microanalysis; Glycerylphosphorylcholine; Inositol; Kidney Concentrating Ability; Kidney Medulla; Kidney Tubules, Collecting; Male; Potassium, Dietary; Rats; Rats, Wistar; Sodium, Dietary; Sorbitol; Urea; Water-Electrolyte Balance | 2000 |
Overexpression of Na(+)-dependent myo-inositol transporter gene in mouse lens led to congenital cataract.
Topics: Aldehyde Reductase; Animals; Blotting, Northern; Carrier Proteins; Cataract; Dietary Carbohydrates; Gene Expression; Heat-Shock Proteins; In Situ Hybridization; Inositol; Lens, Crystalline; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Osmotic Pressure; Sorbitol; Symporters | 2000 |
Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance.
Topics: Diabetes Mellitus, Type 1; Diabetic Neuropathies; Glucose Intolerance; Glucose Tolerance Test; Humans; Inositol; Male; Middle Aged; Nerve Degeneration; Nerve Fibers, Myelinated; Prospective Studies; Reference Values; Sensory Thresholds; Sorbitol; Sural Nerve; Vibration | 2000 |
Spontaneous age-related peripheral neuropathy in B6C3F1 mice.
Topics: Aging; Animals; Axons; Blood Glucose; Body Temperature; Cell Division; Female; Glycated Hemoglobin; Inositol; Mice; Nerve Degeneration; Neural Conduction; Peripheral Nervous System; Peripheral Nervous System Diseases; Schwann Cells; Sciatic Nerve; Sorbitol | 2000 |
Evaluation of alpha(1)-adrenoceptor antagonist on diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense.
Topics: Adrenergic alpha-Antagonists; Animals; Antioxidants; Blood Glucose; Blood Pressure; Body Weight; Creatine; Diabetes Mellitus, Experimental; Glutathione; Hexoses; Inositol; Male; Malondialdehyde; Mitochondria; NAD; Oxidative Stress; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Regional Blood Flow; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Taurine | 2000 |
Effects of 15-month aldose reductase inhibition with fidarestat on the experimental diabetic neuropathy in rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Fructose; Glycated Hemoglobin; Imidazoles; Imidazolidines; Inositol; Male; Myelin Sheath; Nerve Fibers; Peripheral Nerves; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Sural Nerve; Tibial Nerve; Time Factors | 2000 |
Evaluation of an aldose reductase inhibitor on lens metabolism, ATPases and antioxidative defense in streptozotocin-diabetic rats: an intervention study.
Topics: Adenine Nucleotides; Adenosine Triphosphatases; Aldehyde Reductase; Animals; Antioxidants; Ca(2+) Mg(2+)-ATPase; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Fructose; Glucose; Imidazoles; Imidazolidines; Inositol; Lens, Crystalline; Male; NAD; NADP; Proton-Translocating ATPases; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Sorbitol | 2000 |
Clinical usefulness of measuring urinary polyol excretion by gas-chromatography/mass-spectrometry in type 2 diabetes to assess polyol pathway activity.
Topics: Adult; Albuminuria; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Diabetic Retinopathy; Fasting; Female; Fructose; Gas Chromatography-Mass Spectrometry; Glycosuria; Humans; Inositol; Male; Middle Aged; Predictive Value of Tests; Reference Values; Regression Analysis; Sorbitol | 2001 |
Cell and molecular biology of organic osmolyte accumulation in hypertonic renal cells.
Topics: Animals; Betaine; Carrier Proteins; Heat-Shock Proteins; Humans; Hypertonic Solutions; Inositol; Kidney Medulla; Membrane Proteins; Osmosis; Signal Transduction; Sorbitol; Symporters; Trans-Activators; Transcription Factors; Transcriptional Activation | 2001 |
Slowing of motor nerve conduction velocity in streptozotocin-induced diabetic rats is preceded by impaired vasodilation in arterioles that overlie the sciatic nerve.
Topics: Acetylcholine; Animals; Arterioles; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Endothelium, Vascular; Fructose; Glutathione; Inositol; Male; Motor Neurons; Neural Conduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Superoxides; Thiobarbituric Acid Reactive Substances; Time Factors; Vasodilation | 2000 |
Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve.
Topics: Animals; Antioxidants; Aorta; Arterioles; Diabetes Mellitus, Experimental; Dietary Supplements; Inositol; Male; Microscopy, Video; Motor Neurons; Muscle, Smooth, Vascular; Neural Conduction; Nitrates; Rats; Rats, Sprague-Dawley; Reference Values; Regional Blood Flow; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Superoxides; Thioctic Acid; Vasodilation | 2001 |
Effect of M40403 treatment of diabetic rats on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve.
Topics: Acetylcholine; Animals; Blood Glucose; Blood Vessels; Body Weight; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Fructose; Inositol; Male; Manganese; Neural Conduction; Organometallic Compounds; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Sciatic Nerve; Sodium-Potassium-Exchanging ATPase; Sorbitol; Superoxides; Thiobarbituric Acid Reactive Substances; Triglycerides; Tyrosine; Vasodilation; Vasodilator Agents | 2001 |
Polarized function of thick ascending limbs of Henle cells in osmoregulation.
Topics: Animals; Betaine; Cell Line; Cell Membrane; Cell Polarity; Choline; Glycerylphosphorylcholine; Inositol; Intracellular Membranes; Loop of Henle; Rabbits; Sorbitol; Tissue Distribution; Water-Electrolyte Balance | 2001 |
Volume increase in growth plate chondrocytes during hypertrophy: the contribution of organic osmolytes.
Topics: Amino Acids; Animals; Betaine; Cattle; Cell Differentiation; Cell Size; Chondrocytes; Growth Plate; Hypertrophy; Inositol; Osteogenesis; Ribs; Sorbitol; Water-Electrolyte Balance | 2002 |
Organic osmolytes betaine, sorbitol and inositol are potent inhibitors of erythrocyte membrane ATPases.
Topics: Adenosine Triphosphatases; Betaine; Enzyme Inhibitors; Erythrocyte Membrane; Inositol; Osmolar Concentration; Sorbitol; Urea | 2002 |
COX2 activity promotes organic osmolyte accumulation and adaptation of renal medullary interstitial cells to hypertonic stress.
Topics: Adaptation, Physiological; Aldehyde Reductase; Animals; Apoptosis; Betaine; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dehydration; DNA Fragmentation; Gene Expression; Heat-Shock Proteins; Hypertonic Solutions; In Situ Nick-End Labeling; Inositol; Isoenzymes; Kidney Medulla; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Prostaglandin-Endoperoxide Synthases; RNA, Messenger; Sorbitol; Symporters; Tritium | 2003 |
Mammalian osmolytes and S-nitrosoglutathione promote Delta F508 cystic fibrosis transmembrane conductance regulator (CFTR) protein maturation and function.
Topics: 3T3 Cells; Animals; Betaine; Cells, Cultured; Cystic Fibrosis Transmembrane Conductance Regulator; Inositol; Kidney Tubules, Collecting; Mammals; Mice; Nitric Oxide Donors; Osmolar Concentration; Patch-Clamp Techniques; S-Nitrosoglutathione; Sequence Deletion; Sorbitol; Stress, Mechanical; Taurine; Transfection | 2003 |
Glutamate counteracts the denaturing effect of urea through its effect on the denatured state.
Topics: Amino Acyl-tRNA Synthetases; Animals; Betaine; Carbonic Anhydrases; Cattle; Dose-Response Relationship, Drug; Escherichia coli; Glutamates; Glutamic Acid; Inositol; Kinetics; Methylamines; Oxidants; Potassium Chloride; Protein Binding; Protein Conformation; Protein Denaturation; Protein Folding; Sorbitol; Spectrophotometry; Temperature; Thermodynamics; Time Factors; Trypsin; Tubulin; Urea | 2003 |
Some non-reducing carbohydrates in animal tissues and fluids.
Topics: Animals; Blood Chemical Analysis; Fructose; Glycerol; Humans; Inositol; Male; Semen; Seminal Vesicles; Sorbitol | 1962 |
OBSERVATIONS ON RETTGERELLA AND PROVIDENCIA ISOLATED FROM CASES OF ACUTE GASTROENTERITIS IN UTTAR PRADESH.
Topics: Alcohols; Arabinose; Bacteriological Techniques; Citrates; Fermentation; Gastroenteritis; Glucose; Glycosides; India; Inositol; Lactose; Maltose; Mannitol; Pentoses; Proteus Infections; Providencia; Sorbitol; Sucrose; Xylose | 1963 |
A COMPARISON OF METHODS FOR THE CLASSIFICATION OF MYCOBACTERIA. UTILIZATION OF CARBON SOURCES AND DEAMIDASE TESTS.
Topics: Alcohols; Amides; Amidohydrolases; Arabinose; Benzoates; Carbon; Citrates; Classification; Fructose; Galactose; Glucose; Inositol; Mannitol; Mannose; Metabolism; Mycobacterium; Mycobacterium bovis; Mycobacterium tuberculosis; Oligosaccharides; Propionates; Pyruvates; Research; Sorbitol; Succinates | 1963 |
FACTORS AFFECTING THE FORMATION OF SUGAR ALCOHOLS IN OCULAR LENS.
Topics: Alcohols; Animals; Carbohydrate Metabolism; Carbon Isotopes; Cattle; Chromatography; Fructose; Glucose; Inositol; Lens, Crystalline; Oxidoreductases; Pharmacology; Rabbits; Rats; Research; Sorbitol; Sugar Alcohols | 1963 |
DETECTION OF NON-REDUCING CARBOHYDRATE COMPOUNDS WITH COMPLEX CUPRATES. III.
Topics: Chromatography; Copper; Disaccharides; Glycosides; Inositol; Lactones; Mannitol; Oligosaccharides; Research; Sorbitol; Sucrose; Tellurium | 1964 |
THE FERMENTATIVE ABILITY OF "PARACOLON BACILLI".
Topics: Arabinose; Bacillus; Dextrans; Enterobacteriaceae; Escherichia; Fermentation; Fructose; Galactose; Glucose; Glycogen; Inositol; Inulin; Lactose; Maltose; Mannitol; Mannose; Research; Salmonella; Shigella; Sorbitol; Starch; Xylose | 1964 |
THE EFFECT OF DIABETES ON THE CONTENT OF SORBITOL, GLUCOSE, FRUCTOSE AND INOSITOL IN THE HUMAN LENS.
Topics: Aging; Cataract; Diabetes Mellitus; Fructose; Geriatrics; Glucose; Humans; Inositol; Lens, Crystalline; Metabolism; Sorbitol | 1964 |
[THE SCHERER REACTION ON A SUBSTRATE].
Topics: Chromatography; Glucose; Inositol; Mannitol; Sorbitol | 1965 |
[THE SCHERER REACTION ON A SUBSTRATE].
Topics: Chromatography; Glucose; Inositol; Mannitol; Sorbitol | 1965 |
EPIDEMIOLOGICAL AND BIOCHEMICAL STUDIES OF CATARACT AND DIABETES.
Topics: Carbohydrate Metabolism; Cataract; Cataract Extraction; Diabetes Mellitus; England; Epidemiology; Fructose; Geriatrics; Glucose; Humans; Inositol; Lens, Crystalline; Sorbitol | 1965 |
Ksg1, a homologue of the phosphoinositide-dependent protein kinase 1, controls cell wall integrity in Schizosaccharomyces pombe.
Topics: Cell Wall; Genes, Fungal; Genetic Complementation Test; Glucan Endo-1,3-beta-D-Glucosidase; Inositol; Multienzyme Complexes; Mutation; Peptide Hydrolases; Protein Binding; Protein Kinases; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sorbitol; Suppression, Genetic; Temperature; Two-Hybrid System Techniques; Water-Electrolyte Balance | 2003 |
High-resolution magic angle spinning 1H NMR spectroscopy of metabolic changes in rabbit lens after treatment with dexamethasone combined with UVB exposure.
Topics: Administration, Topical; Animals; Cataract; Combined Modality Therapy; Dexamethasone; Glucocorticoids; Glucose; Glutathione; Hexosephosphates; Inositol; Lactic Acid; Lens, Crystalline; Nuclear Magnetic Resonance, Biomolecular; Protons; Rabbits; Radiation Injuries, Experimental; Sorbitol; Taurine; Ultraviolet Rays | 2004 |
Polyol concentrations in the fluid compartments of the human conceptus during the first trimester of pregnancy: maintenance of redox potential in a low oxygen environment.
Topics: Embryo, Mammalian; Female; Fetus; Fructose; Galactose; Gestational Age; Glucose; Glycerol; Humans; Inositol; Mannose; Oxidation-Reduction; Oxygen Consumption; Polymers; Pregnancy; Pregnancy Trimester, First; Sorbitol | 2005 |
Genetic variation in primary metabolites of Pastinaca sativa; can herbivores act as selective agents?
Topics: 5-Methoxypsoralen; Animals; Cluster Analysis; Fatty Acids; Ficusin; Fructose; Fruit; Furocoumarins; Genetic Variation; Inositol; Insecta; Methoxsalen; Pastinaca; Phenotype; Proteins; Sorbitol | 2004 |
Modulation of renal-specific oxidoreductase/myo-inositol oxygenase by high-glucose ambience.
Topics: Animals; Blood Glucose; Blotting, Northern; Blotting, Western; Cells, Cultured; Diabetes Mellitus, Type 2; DNA Primers; Electrophoretic Mobility Shift Assay; Gene Expression Regulation, Enzymologic; Glucose; Hydrogen Peroxide; Inositol; Inositol Oxygenase; Kidney; Luciferases; Male; Mice; Mice, Inbred NOD; Oxidoreductases; Response Elements; Sorbitol; Substrate Specificity; Transfection; Water-Electrolyte Balance | 2005 |
Aldose reductase-deficient mice are protected from delayed motor nerve conduction velocity, increased c-Jun NH2-terminal kinase activation, depletion of reduced glutathione, increased superoxide accumulation, and DNA damage.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; DNA Damage; Enzyme Activation; Fructose; Genes, Reporter; Glucose; Glutathione; Inositol; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Knockout; Motor Neurons; Neural Conduction; Poly Adenosine Diphosphate Ribose; Reference Values; Sorbitol; Superoxides; Sural Nerve | 2006 |
An engineered sorbitol cycle alters sugar composition, not growth, in transformed tobacco.
Topics: Antisense Elements (Genetics); Carbohydrate Metabolism; Fructokinases; Inositol; L-Iditol 2-Dehydrogenase; Nicotiana; Solanum lycopersicum; Sorbitol; Sugar Alcohol Dehydrogenases; Transformation, Genetic | 2006 |
Cold exposure and associated metabolic changes in adult tropical beetles exposed to fluctuating thermal regimes.
Topics: Acclimatization; Alanine; Amino Acids; Amino Acids, Essential; Animals; Arginine; Body Temperature; Cold Temperature; Glucose; Glutamic Acid; Glutamine; Glycerol; Inositol; Lysine; Proline; Ribitol; Sorbitol; Survival Analysis; Temperature; Tenebrio; Threonine; Trehalose; Tropical Climate; Valine | 2007 |
Optimising the viability during storage of freeze-dried cell preparations of Campylobacter jejuni.
Topics: Campylobacter jejuni; Cryoprotective Agents; Freeze Drying; Inositol; Microbial Viability; Peptones; Sorbitol; Trehalose | 2007 |
[Assessment of therapeutic effect of losartan on diabetes mellitus with gas chromatography-based metabonomics].
Topics: 8-Hydroxy-2'-Deoxyguanosine; Albuminuria; Biomarkers; Chromatography, Gas; Creatinine; Deoxyguanosine; Diabetes Mellitus; Diabetes Mellitus, Type 2; Drug Monitoring; Humans; Hypoglycemic Agents; Inositol; Losartan; Metabolome; Sorbitol | 2007 |
Hyperglycemia not hypoglycemia alters neuronal dendrites and impairs spatial memory.
Topics: Animals; Brain Chemistry; Cerebral Cortex; Dendrites; Dendritic Spines; Diabetes Mellitus, Experimental; Hippocampus; Hyperglycemia; Hypoglycemia; Inositol; Maze Learning; Memory; Memory Disorders; Neurons; Rats; Rats, Wistar; Sorbitol; Spatial Behavior; Taurine | 2008 |
Effects of cryoprotectant treatments on bovine sperm function and osmolyte content.
Topics: Animals; Carnitine; Cattle; Cryoprotective Agents; Glutamic Acid; Inositol; Male; Osmolar Concentration; Semen Preservation; Sorbitol; Sperm Motility; Spermatozoa | 2009 |
Determination of the NFAT5/TonEBP transcription factor in the human and ovine placenta.
Topics: Animals; Female; Humans; Inositol; Osmolar Concentration; Placenta; Pregnancy; RNA, Messenger; Sheep; Sorbitol; Transcription Factors | 2009 |
The tissue and plasma concentration of polyols and sugars in sheep intrauterine growth retardation.
Topics: Animals; Carbohydrate Metabolism; Carbohydrates; Female; Fetal Growth Retardation; Fetus; Fructose; Inositol; Liver; Mannose; Maternal-Fetal Exchange; Myo-Inositol-1-Phosphate Synthase; Placenta; Polymers; Pregnancy; Sheep; Sorbitol; Umbilical Cord | 2010 |
Placental TonEBP/NFAT5 osmolyte regulation in an ovine model of intrauterine growth restriction.
Topics: Aldehyde Reductase; Animals; Female; Fetal Growth Retardation; Inositol; Models, Animal; NADP; NFATC Transcription Factors; Osmolar Concentration; Placenta; Pregnancy; Pregnancy, Animal; RNA, Messenger; Sheep; Sorbitol; Symporters | 2012 |
Deciphering the metabolic changes associated with diapause syndrome and cold acclimation in the two-spotted spider mite Tetranychus urticae.
Topics: Acclimatization; Animals; Cadaverine; Cluster Analysis; Cold Temperature; Discriminant Analysis; Female; Gas Chromatography-Mass Spectrometry; Gluconates; Glucose; Inositol; Lactones; Least-Squares Analysis; Maltose; Mannitol; Metabolome; Metabolomics; Sorbitol; Tetranychidae | 2013 |
Testing the ability of non-methylamine osmolytes present in kidney cells to counteract the deleterious effects of urea on structure, stability and function of proteins.
Topics: Enzyme Stability; Humans; Hydrogen-Ion Concentration; Inositol; Kidney; Lactalbumin; Methylamines; Muramidase; Osmolar Concentration; Protein Denaturation; Protein Structure, Secondary; Ribonuclease, Pancreatic; Sorbitol; Taurine; Urea | 2013 |
Distinctive solvation patterns make renal osmolytes diverse.
Topics: Betaine; Inositol; Kidney; Models, Molecular; Molecular Conformation; Osmosis; Phosphorylcholine; Solubility; Solvents; Sorbitol; Taurine | 2013 |
Characterization of new polyol/H+ symporters in Debaryomyces hansenii.
Topics: Biological Transport; Debaryomyces; Galactose; Glycerol; Hydrogen; Inositol; Mannitol; Polymers; Saccharomyces cerevisiae; Sorbitol; Sugar Alcohols; Symporters | 2014 |
Increased trophoblast expression of NFAT5/TonEBP in pre-eclamptic placentas and hyperosmolar-treated BeWo cells.
Topics: Aldehyde Reductase; Case-Control Studies; Cells, Cultured; Choriocarcinoma; Extracellular Signal-Regulated MAP Kinases; Female; Heat-Shock Proteins; Humans; In Vitro Techniques; Inositol; Osmolar Concentration; Placenta; Pre-Eclampsia; Pregnancy; Saline Solution, Hypertonic; Sorbitol; Symporters; Transcription Factors; Trophoblasts; Uterine Neoplasms | 2014 |
Metabolic Dysfunction Is Restricted to the Sciatic Nerve in Experimental Diabetic Neuropathy.
Topics: Animals; Carnitine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Energy Metabolism; Fructose; Ganglia, Spinal; Glucose; Homeostasis; Inositol; Lipid Metabolism; Lumbar Vertebrae; Metabolomics; Mitochondria; Neural Conduction; Oxidative Phosphorylation; Oxidative Stress; Polymers; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sorbitol; Trigeminal Ganglion | 2016 |
Effect of mammalian kidney osmolytes on the folding pathway of sheep serum albumin.
Topics: Animals; Betaine; Guanidine; Inositol; Kidney; Osmosis; Protein Denaturation; Protein Folding; Protein Stability; Serum Albumin; Sheep; Sorbitol; Thermodynamics; Urea | 2017 |
TonEBP/NFAT5 regulates downstream osmoregulatory proteins during freeze-thaw stress in the wood frog.
Topics: Adaptation, Physiological; Aldehyde Reductase; Animals; Betaine; Carrier Proteins; Cold Temperature; Crystallization; Dehydration; Freezing; GABA Plasma Membrane Transport Proteins; Gene Expression Regulation; Heat-Shock Proteins; Inositol; Kidney; Liver; Muscle, Skeletal; NFATC Transcription Factors; Osmoregulation; Osmotic Pressure; Ranidae; Sorbitol; Symporters; Transcriptional Activation; Up-Regulation | 2017 |
Counteraction of the deleterious effects of urea on structure and stability of mammalian kidney proteins by osmolytes.
Topics: Animals; Betaine; Guanidine; Inositol; Kidney; Mammals; Osmolar Concentration; Protein Stability; Proteins; Sheep; Sorbitol; Urea | 2018 |
The aldose reductase inhibitor epalrestat exerts nephritic protection on diabetic nephropathy in db/db mice through metabolic modulation.
Topics: Albuminuria; Aldehyde Reductase; Animals; Diabetic Nephropathies; Enzyme Inhibitors; Fructose; Inositol; Kidney; Male; Metabolomics; Mice; Protective Agents; Rhodanine; Sorbitol; Thiazolidines | 2019 |
Do Osmolytes Impact the Structure and Dynamics of Myoglobin?
Topics: Betaine; Circular Dichroism; Inositol; Myoglobin; Osmosis; Protein Stability; Sorbitol; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Taurine; Temperature; Trehalose | 2018 |
The effect of tacrolimus-induced toxicity on metabolic profiling in target tissues of mice.
Topics: Animals; Fructose; Glycerol; Inositol; Mice; Sorbitol; Tacrolimus | 2022 |