inosinic-acid and guanidinopropionic-acid
inosinic-acid has been researched along with guanidinopropionic-acid* in 1 studies
Other Studies
1 other study(ies) available for inosinic-acid and guanidinopropionic-acid
Article | Year |
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Adaptation of rat skeletal muscle to creatine depletion: AMP deaminase and AMP deamination.
AMP deaminase catalyzes deamination of the AMP formed in contracting muscles to inosine 5'-monophosphate (IMP). Slow-twitch muscle has only approximately 30% as high a level of AMP deaminase activity as fast-twitch muscle in the rat, and rates of IMP formation during intense contractile activity are much lower in slow-twitch muscle. We found that feeding the creatine analogue beta-guanidinopropionic acid (beta-GPA) to rats, which results in creatine depletion, causes a large decrease in muscle AMP deaminase. This adaptation was used to evaluate the role of AMP deaminase activity level in accounting for differences in IMP production in slow-twitch and fast-twitch muscles. beta-GPA feeding for 3 wk lowered AMP deaminase activity in fast-twitch epitrochlearis muscle to a level similar to that found in the normal slow-twitch soleus muscle but had no effect on the magnitude of the increase in IMP in response to intense contractile activity. Despite a similar decrease in ATP in the normal soleus and the epitrochlearis from beta-GPA-fed rats, the increase in IMP was only approximately 30% as great in the soleus in response to intense contractile activity. These results demonstrate that the accumulation of less IMP in slow- compared with fast-twitch skeletal muscle during contractile activity is not due to the lower level of AMP deaminase in slow-twitch muscle. Topics: Adaptation, Physiological; Adenosine Monophosphate; AMP Deaminase; Animals; Creatine; Deamination; Diet; Guanidines; Inosine Monophosphate; Male; Muscle Contraction; Muscles; Propionates; Rats; Rats, Wistar | 1992 |