inosinic-acid and coumarin

inosinic-acid has been researched along with coumarin* in 1 studies

Other Studies

1 other study(ies) available for inosinic-acid and coumarin

Article	Year
Cyclic adenosine 5'-diphosphoribose (cADPR) mimics used as molecular probes in cell signaling. Chemical record (New York, N.Y.), 2015, Volume: 15, Issue:2 Cyclic adenosine 5'-diphosphate ribose (cADPR) is a second messenger in the Ca(2+) signaling pathway. To elucidate its molecular mechanism in calcium release, a series of cADPR analogues with modification on ribose, nucleobase, and pyrophosphate have been investigated. Among them, the analogue with the modification of the northern ribose by ether linkage substitution (cIDPRE) exhibits membrane-permeate Ca(2+) agonistic activity in intact HeLa cells, human T cells, mouse cardiac myocytes and neurosecretory PC12 cell lines; thus, cIDPRE and coumarin-caged cIDPRE are valuable probes to investigate the cADPR-mediated Ca(2+) signal pathway. Topics: Animals; Calcium; Calcium Signaling; Coumarins; Cyclic ADP-Ribose; HeLa Cells; Humans; Inosine Monophosphate; Jurkat Cells; Mice; Molecular Mimicry; Molecular Probes; Myocytes, Cardiac; PC12 Cells; Rats; Structure-Activity Relationship	2015

Article

Year

Cyclic adenosine 5'-diphosphoribose (cADPR) mimics used as molecular probes in cell signaling.

Chemical record (New York, N.Y.), 2015, Volume: 15, Issue:2

Cyclic adenosine 5'-diphosphate ribose (cADPR) is a second messenger in the Ca(2+) signaling pathway. To elucidate its molecular mechanism in calcium release, a series of cADPR analogues with modification on ribose, nucleobase, and pyrophosphate have been investigated. Among them, the analogue with the modification of the northern ribose by ether linkage substitution (cIDPRE) exhibits membrane-permeate Ca(2+) agonistic activity in intact HeLa cells, human T cells, mouse cardiac myocytes and neurosecretory PC12 cell lines; thus, cIDPRE and coumarin-caged cIDPRE are valuable probes to investigate the cADPR-mediated Ca(2+) signal pathway.

Topics: Animals; Calcium; Calcium Signaling; Coumarins; Cyclic ADP-Ribose; HeLa Cells; Humans; Inosine Monophosphate; Jurkat Cells; Mice; Molecular Mimicry; Molecular Probes; Myocytes, Cardiac; PC12 Cells; Rats; Structure-Activity Relationship

2015