inosine-triphosphate has been researched along with tazanolast* in 1 studies
1 other study(ies) available for inosine-triphosphate and tazanolast
Article | Year |
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Effect of an active metabolite of the antiallergic agent tazanolast on histamine release from rat mast cells.
WP-871 (3'-(1H-tetrazol-5-yl)oxanilic acid monohydrate, CAS 114607-46-4) is a monohydrate of a main active metabolite of tazanolast (butyl 3'-(1H-tetrazol-5-yl) oxanilate, CAS 82989-25-1), an orally active antiallergic drug. WP-871 inhibited dose-dependently compound 48/80-induced histamine release from rat peritoneal mast cells. In a similar dose range, WP-871 was effective in inhibiting compound 48/80-induced 45Ca uptake into mast cells from extracellular medium and compound 48/80-induced translocation of protein kinase C from the cytosol to the membrane fraction of mast cells. WP-871 also inhibited inositol trisphosphate production but did not exhibit a direct inhibitory effect on phospholipase C in mast cells. WP-871 caused no increase in cAMP content in mast cells. These results suggest that WP-871 may inhibit histamine release mainly by preventing the increase in intracellular Ca2+ concentration, which is a critical event in signal transduction leading to histamine release in mast cells. Topics: Animals; Anti-Allergic Agents; Calcium Radioisotopes; Cyclic AMP; Dose-Response Relationship, Drug; Histamine Release; In Vitro Techniques; Inosine Triphosphate; Male; Mast Cells; Oxalates; Protein Kinase C; Rats; Rats, Wistar; Tetrazoles; Type C Phospholipases | 1997 |