inosine-diphosphate and emoxypine-succinate

The aims of our experiments on animals were (i) to evaluate by direct oximery the efficiency of various antioxidant drugs in a complex treatment of acute pancreatitis and (ii) to determine the diagnostic value of the direct oximetry method for estimation of the efficiency of medical treatment. The article presents data obtained in a group 75 outbred Guinea with a model acute pancreatitis, which were treated with mexibel (group 1), emoxipin (group 2), end cytoflavin (group 3), with subsequent investigation of the pancreatic tissues by the direct oximetry method. The obtained results confirmed that the intraperitoneal injection of cytoflavin to animals stimulates tissue respiration, improves metabolism, promotes pancreas recovery, and also improves the prognosis and reduces the lethal outcome. The efficiency of cytoflavin within the complex therapy exceeds the effect of other antioxidants (mexibel and emoxipin) under otherwise equal conditions.

Topics: Acute Disease; Animals; Antioxidants; Disease Models, Animal; Drug Combinations; Flavin Mononucleotide; Guinea Pigs; Injections, Intraperitoneal; Inosine Diphosphate; Niacinamide; Oxygen; Oxygen Consumption; Pancreas; Pancreatitis; Partial Pressure; Picolines; Succinates; Treatment Outcome

Experiment carried out on laboratory animals (rats) were aimed at comparative evaluation of the effect of several neuroprotective drugs under the conditions of model brain ischemia-reperfusion. The experimental methods included staining of brain tissue sections by hematoxiline-eosine, Nissl staining, and expression of NOS1, NOS3, TRAIL by imunnohistological means. The intensity of damage in various parts of brain and the nature of apoptosis without neuroprotection and with popular neuroprotectors (cytoflavin, actovegin, mexidol) and a test drug at the stage ofpreclinical trial (AKF-90-7) were evaluated. Characteristic cytotoxic (coagulative pycnomorphic and colliquative necrosis of neurons) and vascular (hemostasia, erythropedesis) changes were revealed. The neuroprotective effectof drugs decreases in the following order: AKF-90-7 > cytoflavin > actovegin > mexidol.

Topics: Animals; Brain; Drug Combinations; Drug Evaluation, Preclinical; Eosine Yellowish-(YS); Flavin Mononucleotide; Glycine; Hematoxylin; Heme; Hemostasis; Immunohistochemistry; Inosine Diphosphate; Male; Necrosis; Neurons; Neuroprotective Agents; Niacinamide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Picolines; Rats; Rats, Inbred Strains; Reperfusion Injury; Succinates; TNF-Related Apoptosis-Inducing Ligand