inosine and forodesine

inosine has been researched along with forodesine* in 1 studies

Other Studies

1 other study(ies) available for inosine and forodesine

Article	Year
Immucillins in custom catalytic-site cavities. Bioorganic & medicinal chemistry letters, 2008, Nov-15, Volume: 18, Issue:22 Neighboring-group participation in the reaction catalyzed by purine nucleoside phosphorylase involves a compression mode between the 5'- and 4'-ribosyl oxygens, facilitated by His257. The His257Gly mutant opens a space in the catalytic site. Hydrophobic 5'-substituted Immucillins are transition-state analogue inhibitors of this mutant enzyme. Dissociation constants as low as 2pM are achieved, with K(m)/K(d) as high as 400,000,000. Topics: Catalytic Domain; Crystallography, X-Ray; Glycine; Histidine; Humans; Imidazoles; Kinetics; Mutation; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Structure-Activity Relationship	2008

Article

Year

Immucillins in custom catalytic-site cavities.

Bioorganic & medicinal chemistry letters, 2008, Nov-15, Volume: 18, Issue:22

Neighboring-group participation in the reaction catalyzed by purine nucleoside phosphorylase involves a compression mode between the 5'- and 4'-ribosyl oxygens, facilitated by His257. The His257Gly mutant opens a space in the catalytic site. Hydrophobic 5'-substituted Immucillins are transition-state analogue inhibitors of this mutant enzyme. Dissociation constants as low as 2pM are achieved, with K(m)/K(d) as high as 400,000,000.

Topics: Catalytic Domain; Crystallography, X-Ray; Glycine; Histidine; Humans; Imidazoles; Kinetics; Mutation; Protein Conformation; Purine Nucleosides; Purine-Nucleoside Phosphorylase; Pyrimidinones; Structure-Activity Relationship

2008