indomethacin has been researched along with simvastatin in 33 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 13 (39.39) | 29.6817 |
| 2010's | 20 (60.61) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Kourounakis, AP; Matralis, AN | 1 |
| Bharate, SS; Vishwakarma, RA | 1 |
| Beaumont, K; Di, L; Maurer, TS; Smith, DA | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cullen, DM; Genrich, MA; Killpack, B; Lee, Y; Marx, DB; Narayana, N; Reinhardt, RA; Schmid, MJ; Stein, D | 1 |
| Ito, S; Ito, Y; Kondo, M; Kume, H; Naruse, K; Oguma, T; Shimokata, K; Suki, B | 1 |
| Hein, TW; Kuo, L; Nagaoka, T; Yoshida, A | 1 |
| Al Moutaery, M; Al Rayes, H; Al Swailam, R; Arshaduddin, M; Elfaki, I; Khan, HA; Tariq, M | 1 |
| Kalgutkar, AS; Obach, RS; Soglia, JR; Zhao, SX | 1 |
| Dobrić, S; Jaćević, V; Milovanović, ZA; Nezić, L; Satara, SS; Skrbić, R; Stojaković, N; Stojiljković, MP | 1 |
| Amin, RS; Hassan, MK; Heeba, GH | 1 |
| Denny, WA; Garg, S; Sharma, P | 1 |
| Buerke, M; Chen, L; Frister, A; Hofmann, B; Lautenschläger, M; Loppnow, H; Luther, T; Müller-Werdan, U; Rose-John, S; Schlitt, A; Silber, RE; Song, N; Werdan, K; Zhang, L | 1 |
| Bragina, VV; Fleischman, MY; Lebedko, OA; Sazonova, EN; Timoshin, SS; Zhivotova, EY | 1 |
| Chuang, CL; Hsin, IF; Hsu, SJ; Huang, HC; Lee, FY; Lee, JY; Lee, SD; Lin, HC; Wang, SS | 1 |
| Shi, NQ; Wang, XL; Yao, J | 1 |
| Löbmann, K; Rades, T; Sibik, J; Zeitler, JA | 1 |
| Cipollone, F; Creemers, EE; de Ronde, MW; Halliani, A; Kok, MG; Mandolini, C; Meijers, JC; Moerland, PD; Nieuwland, R; Pinto-Sietsma, SJ; Sondermeijer, BM | 1 |
| Cho, JH; Chung, JW; Jeong, AR; Kim, EJ; Kim, EK; Kim, JH; Kim, KO; Kim, YJ; Kwon, KA; Park, DK | 1 |
| Grohganz, H; Jensen, KT; Kasten, G; Meng-Lund, H; Pantsar, T; Poso, A; Rades, T; Rantanen, J | 1 |
2 review(s) available for indomethacin and simvastatin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[The development of co-amorphous drug systems].
Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Cimetidine; Drug Combinations; Drug Compounding; Drug Stability; Glipizide; Indomethacin; Naproxen; Ranitidine; Simvastatin; Solubility; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Technology, Pharmaceutical; Temperature; X-Ray Diffraction | 2013 |
1 trial(s) available for indomethacin and simvastatin
| Article | Year |
|---|---|
Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures.
Topics: Aspirin; Atorvastatin; Cell Separation; Coculture Techniques; Dose-Response Relationship, Drug; Drug Synergism; Heptanoic Acids; HMGB1 Protein; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Interleukin-1; Interleukin-6; Leukocytes, Mononuclear; Lipopolysaccharides; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Pyrroles; Recombinant Proteins; Simvastatin; STAT3 Transcription Factor; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
30 other study(ies) available for indomethacin and simvastatin
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Design of novel potent antihyperlipidemic agents with antioxidant/anti-inflammatory properties: exploiting phenothiazine's strong antioxidant activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Atherosclerosis; Biphenyl Compounds; Carrageenan; Cholesterol, Dietary; Cyclooxygenase Inhibitors; Diet, High-Fat; Drug Design; Edema; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Hypolipidemic Agents; In Vitro Techniques; Indicators and Reagents; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Male; Mice; Microsomes; Phenothiazines; Picrates; Rats | 2014 |
Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.
Topics: Drug Discovery; Pharmaceutical Preparations; Solubility; Thermodynamics | 2015 |
Volume of Distribution in Drug Design.
Topics: Drug Design; Half-Life; Pharmacokinetics | 2015 |
Local simvastatin effects on mandibular bone growth and inflammation.
Topics: Animals; Collagenases; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Female; Fibronectins; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Inflammation Mediators; Lactic Acid; Mandible; Matrix Metalloproteinase 13; Membranes, Artificial; Methylcellulose; Mice; Nitrobenzenes; Osteogenesis; Pharmaceutical Vehicles; Polyesters; Polymers; Procollagen; Rats; Simvastatin; Skull; Sulfonamides; Up-Regulation | 2005 |
Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle.
Topics: Amides; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cations; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Gadolinium; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Ion Channels; Male; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitrobenzenes; Protein Serine-Threonine Kinases; Pyrazoles; Pyridines; rho-Associated Kinases; Simvastatin; Stress, Mechanical; Sulfonamides; Trachea | 2006 |
Simvastatin elicits dilation of isolated porcine retinal arterioles: role of nitric oxide and mevalonate-rho kinase pathways.
Topics: Animals; Arterioles; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Female; Guanylate Cyclase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Intracellular Signaling Peptides and Proteins; Male; Mevalonic Acid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Protein Serine-Threonine Kinases; Retinal Artery; rho-Associated Kinases; Simvastatin; Swine; Vasodilation; Vasomotor System | 2007 |
Gastric antisecretory and antiulcer effects of simvastatin in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Ethanol; Female; Gastric Acid; Gastric Mucosa; Indomethacin; Ligation; Male; Mucus; Nitric Oxide; Peroxidase; Pylorus; Rats; Rats, Wistar; Simvastatin; Stomach Ulcer; Sulfhydryl Compounds | 2007 |
Can in vitro metabolism-dependent covalent binding data in liver microsomes distinguish hepatotoxic from nonhepatotoxic drugs? An analysis of 18 drugs with consideration of intrinsic clearance and daily dose.
Topics: Acetaminophen; Binding Sites; Buspirone; Carbamazepine; Diclofenac; Diphenhydramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Hepatocytes; Humans; Indomethacin; Meloxicam; Microsomes, Liver; Molecular Structure; Paroxetine; Piperazines; Propranolol; Raloxifene Hydrochloride; Simvastatin; Structure-Activity Relationship; Thiazines; Thiazoles; Ticrynafen; Toxicity Tests; Triazoles | 2008 |
Simvastatin and indomethacin have similar anti-inflammatory activity in a rat model of acute local inflammation.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Indomethacin; Inflammation; Male; Neutrophil Infiltration; Rats; Rats, Wistar; Simvastatin | 2009 |
Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: role of nitric oxide and prostaglandins.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arginine; Dinoprostone; Drug Interactions; Drug Synergism; Enzyme Inhibitors; Gastric Juice; Gastric Mucosa; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Simvastatin; Stomach Ulcer | 2009 |
Effect of wet milling process on the solid state of indomethacin and simvastatin.
Topics: Crystallization; Drug Stability; Excipients; Indomethacin; Molecular Structure; Nanoparticles; Particle Size; Poloxamer; Povidone; Simvastatin; Suspensions; Technology, Pharmaceutical | 2009 |
Effect of HMG-CoA-reductase inhibitor on DNA synthesis and free radical oxidation in the gastric mucosa under normal conditions and during indometacin-induced ulcerative process in the stomach of albino mice.
Topics: Animals; Autoradiography; DNA Replication; Free Radicals; Gastric Mucosa; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Luminescent Measurements; Male; Mice; Mice, Mutant Strains; Oxidation-Reduction; Simvastatin; Stomach Ulcer | 2012 |
Effects of simvastatin on the portal-systemic collateral vascular response to endothelin-1 and shunting degree in portal hypertensive rats.
Topics: Animals; Collateral Circulation; Cyclooxygenase Inhibitors; Endothelin-1; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Portal; Indomethacin; Linear Models; Male; Nitric Oxide Synthase; Random Allocation; Rats; Rats, Sprague-Dawley; Simvastatin; Treatment Outcome; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents | 2013 |
Predicting Crystallization of Amorphous Drugs with Terahertz Spectroscopy.
Topics: Acetaminophen; Calorimetry, Differential Scanning; Crystallization; Drug Stability; Flufenamic Acid; Indomethacin; Kinetics; Molecular Dynamics Simulation; Naproxen; Simvastatin; Temperature; Terahertz Spectroscopy; X-Ray Diffraction | 2015 |
Low miR-19b-1-5p expression in isolated platelets after aspirin use is related to aspirin insensitivity.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Aspirin; Blood Platelets; Coronary Artery Disease; Drug Resistance; Humans; Indomethacin; Male; MicroRNAs; Middle Aged; Platelet Aggregation Inhibitors; RNA; Simvastatin | 2016 |
Anti-inflammatory effects of simvastatin in nonsteroidal anti-inflammatory drugs-induced small bowel injury.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 1; Cyclooxygenase 2; Deoxyguanosine; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Interleukin-6; Interleukin-8; Intestinal Diseases; Intestine, Small; Male; Membrane Proteins; Mice, Inbred C57BL; NF-KappaB Inhibitor alpha; Rats; Reactive Oxygen Species; Simvastatin; Tumor Necrosis Factor-alpha | 2017 |
The use of molecular descriptors in the development of co-amorphous formulations.
Topics: Amino Acids; Carbamazepine; Carbazoles; Carvedilol; Chemistry, Pharmaceutical; Discriminant Analysis; Drug Combinations; Drug Stability; Furosemide; Indomethacin; Least-Squares Analysis; Mebendazole; Models, Molecular; Pharmaceutical Preparations; Powder Diffraction; Propanolamines; Simvastatin; X-Ray Diffraction | 2018 |