indomethacin has been researched along with opc 12759 in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 10 (35.71) | 18.2507 |
| 2000's | 6 (21.43) | 29.6817 |
| 2010's | 9 (32.14) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Hotta, K; Ishihara, K; Komuro, Y; Nishiyama, N; Yamasaki, K | 1 |
| Chijiwa, T; Ishiyama, H; Kanbe, T; Morita, S; Yamasaki, K | 1 |
| Iinuma, S; Kaneko, T; Kondo, M; Naito, Y; Nakamura, S; Nishimura, S; Takahashi, S; Yamasaki, K; Yoshikawa, T | 1 |
| Kleine, A; Kluge, S; Peskar, BM | 1 |
| Kim, BK; Kim, HK; Kim, WB; Son, M; Yang, J | 1 |
| Harada, N; Johno, M; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M | 1 |
| Kondo, M; Naito, Y; Yoshida, N; Yoshikawa, T | 1 |
| Boku, Y; Fujii, T; Iinuma, S; Kondo, M; Matsuyama, K; Naito, Y; Sasaki, E; Yagi, N; Yoshida, N; Yoshikawa, T | 1 |
| Harada, N; Isobe, H; Murakami, K; Okabe, H; Okajima, K | 1 |
| Fitzpatrick, LR; Le, T; Sakurai, K | 1 |
| Arakawa, T; Higuchi, K; Kobayashi, K; Kuroki, T; Takaishi, O; Yamasaki, K | 1 |
| Kanatsu, K; Kato, S; Mizoguchi, H; Ogawa, Y; Takeuchi, K; Tanaka, A | 1 |
| Alexander, JS; Itoh, M; Joh, T; Nomura, T; Ohara, H; Oshima, T; Sasaki, M; Seno, K; Takezono, Y; Yokoyama, Y | 1 |
| Handa, O; Ichikawa, H; Kajikawa, H; Katada, K; Kokura, S; Kuroda, M; Matsui, H; Mizushima, K; Naito, Y; Shimozawa, M; Takagi, T; Yoshida, N; Yoshikawa, T | 1 |
| Matsui, H; Matsuzaki, Y; Muramatsu, M; Nagano, Y; Nakahara, A; Nakamura, Y; Shibahara, T; Shimokawa, O; Tanaka, N; Yanaka, A | 1 |
| Futagami, S; Gudis, K; Hamamoto, T; Hiratsuka, T; Kusunoki, M; Miyake, K; Sakamoto, C; Shindo, T; Shinji, Y; Shinoki, K; Suzuki, K; Tsukui, T; Ueki, N; Wada, K | 1 |
| Naito, Y; Yoshikawa, T | 1 |
| Andoh, A; Fujimoto, T; Fujiyama, Y; Imaeda, H; Kasumi, E; Takahashi, K | 1 |
| Fukumoto, K; Handa, O; Harusato, A; Horie, R; Ichikawa, H; Inoue, K; Mizushima, K; Naito, Y; Takagi, T; Uchiyama, K; Yagi, N; Yamada, S; Yoshikawa, T | 1 |
| Arakawa, T; Fujiwara, Y; Nadatani, Y; Ohkawa, F; Otani, K; Shiba, M; Sogawa, M; Takeuchi, K; Tanigawa, T; Tominaga, K; Watanabe, K; Watanabe, T; Yamagami, H | 1 |
| Choi, WS; Lee, GR; Lee, SE; Oh, S; Son, DJ | 1 |
| Abe, N; Funato, H; Hirata, A; Iizuka, M; Jobu, K; Kadota, A; Miyamura, M; Nakai, M; Ogi, K; Shiraishi, H; Yagi, Y; Yokota, J | 1 |
| Castagné, V; Goineau, S | 1 |
| Hashita, T; Iwao, T; Kondo, S; Matsunaga, T; Mizuno, S | 1 |
| Deguchi, S; Nagai, N; Otake, H; Sakamoto, R; Tanino, T; Yamamoto, S | 1 |
| Fujiwara, Y; Fukunaga, S; Hattori, M; Higashimori, A; Hosomi, S; Kamata, N; Kitamura, H; Kuzumoto, T; Nadatani, Y; Nagami, Y; Otani, K; Shiba, M; Shimada, S; Suda, W; Taira, K; Tanaka, F; Tanigawa, T; Watanabe, T | 1 |
| Chadha, R; Dureja, J; Jindal, A; Karan, M; Singh, R; Tomar, S | 1 |
2 review(s) available for indomethacin and opc 12759
| Article | Year |
|---|---|
Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Free Radicals; Gastric Mucosa; Humans; Indomethacin; Lipid Peroxidation; Oxygen; Quinolones | 1998 |
Oxidative stress involvement and gene expression in indomethacin-induced gastropathy.
Topics: Alanine; Animals; Anti-Ulcer Agents; Apoptosis; DNA; Gastric Mucosa; Gene Expression Profiling; Gene Expression Regulation; Humans; Indomethacin; Neutrophils; Oligonucleotide Array Sequence Analysis; Oxidative Stress; Quinolones; Rats; Reactive Oxygen Species; Stomach Diseases | 2006 |
1 trial(s) available for indomethacin and opc 12759
| Article | Year |
|---|---|
Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled study.
Topics: Adult; Alanine; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Cytokines; Double-Blind Method; Gastric Mucosa; Humans; Indomethacin; Lipid Peroxidation; Male; Peroxidase; Quinolones; Reference Values; Stomach Ulcer; Treatment Outcome | 1998 |
25 other study(ies) available for indomethacin and opc 12759
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Effect of rebamipide on mucus secretion by endogenous prostaglandin-independent mechanism in rat gastric mucosa.
Topics: Alanine; Animals; Anti-Ulcer Agents; Gastric Mucosa; Glycoproteins; Indomethacin; Male; Mucins; Mucus; Prostaglandins; Quinolones; Rats; Rats, Wistar | 1992 |
Gastric mucosal protection by OPC-12759, a novel antiulcer compound, in the rat.
Topics: Alanine; Animals; Anti-Ulcer Agents; Atropine; Cimetidine; Dinoprostone; Gastric Mucosa; Indomethacin; Injections, Intraperitoneal; Male; Prostaglandins E; Quinolines; Quinolones; Rats; Rats, Inbred Strains | 1987 |
Effect of rebamipide on lipid peroxidation and gastric mucosal injury induced by indometacin in rats.
Topics: Alanine; Animals; Anti-Ulcer Agents; Free Radicals; Gastric Mucosa; Indomethacin; Lipid Peroxidation; Male; Quinolones; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Stomach Ulcer; Thiobarbituric Acid Reactive Substances | 1993 |
Stimulation of prostaglandin biosynthesis mediates gastroprotective effect of rebamipide in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Alanine; Animals; Anti-Ulcer Agents; Dinoprostone; Dose-Response Relationship, Drug; Gastric Juice; In Vitro Techniques; Indomethacin; Male; Prostaglandins; Quinolones; Rats; Rats, Wistar; Thromboxane B2 | 1993 |
Protective effect of taurine on indomethacin-induced gastric mucosal injury.
Topics: Adult; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Gastric Mucosa; Humans; Indomethacin; Lipid Peroxidation; Luminescent Measurements; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Quinolones; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Taurine; Thiobarbituric Acid Reactive Substances; Umbilical Veins | 1996 |
Rebamipide attenuates indomethacin-induced gastric mucosal lesion formation by inhibiting activation of leukocytes in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cimetidine; Gastric Mucosa; Glycine; Humans; In Vitro Techniques; Indomethacin; Leukocyte Elastase; Male; Neutrophil Activation; Neutrophils; Peroxidase; Quinolones; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Sulfonamides | 1997 |
Rebamipide prevents indomethacin-induced gastric mucosal lesion formation by inhibiting activation of neutrophils in rats.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Calcium; Gastric Mucosa; Indomethacin; Leukocyte Elastase; Male; Neutrophils; Peroxidase; Quinolones; Rats; Rats, Wistar; Stomach Ulcer | 1998 |
Indomethacin-induced gastric antral damage in hamsters: are neutrophils involved?
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cricetinae; Gastric Mucosa; Indomethacin; Male; Mesocricetus; Methotrexate; Mice; Neutrophils; Peroxidase; Pyloric Antrum; Quinolones | 1999 |
Influence of rebamipide on indometacin-induced gastric hemorrhage in rats under restraint stress.
Topics: Acute Disease; Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Catalase; Cimetidine; Diterpenes; Gastritis; Gastrointestinal Hemorrhage; Indomethacin; Leukocyte Count; Male; Neutrophils; Omeprazole; Perfusion; Quinolones; Rats; Rats, Wistar; Restraint, Physical; Stress, Psychological; Superoxide Dismutase | 1999 |
Protective effect of rebamipide on indomethacin-induced intestinal damage in rats.
Topics: Alanine; Ampicillin; Animals; Anti-Ulcer Agents; Bacterial Translocation; Catalase; Dose-Response Relationship, Drug; Enterobacteriaceae; Enzyme Inhibitors; Indomethacin; Intestinal Diseases; Lipid Peroxidation; Male; Nitric Oxide Synthase; Peroxidase; Quinolones; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2001 |
The protective effect of rebamipide on paracellular permeability of rat gastric epithelial cells.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cyclooxygenase Inhibitors; Dinoprostone; Epithelial Cells; Gastric Mucosa; Indomethacin; Nitrobenzenes; Permeability; Quinolones; Rats; Sulfonamides | 2003 |
Rebamipide, a gastro-protective drug, inhibits indomethacin-induced apoptosis in cultured rat gastric mucosal cells: association with the inhibition of growth arrest and DNA damage-induced 45 alpha expression.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Cell Culture Techniques; Cell Cycle Proteins; DNA Damage; Dose-Response Relationship, Drug; Down-Regulation; Gastric Mucosa; Gene Expression Profiling; Indomethacin; Nuclear Proteins; Oligonucleotide Probes; Polymerase Chain Reaction; Quinolones; Rats | 2005 |
Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Apoptosis; Cell Culture Techniques; Fluorescent Dyes; Gastric Mucosa; Indomethacin; Lipid Peroxidation; Membrane Potentials; Mitochondria; Quinolones; Rats; Rats, Wistar; Reactive Oxygen Species | 2005 |
Rebamipide reduces indomethacin-induced gastric injury in mice via down-regulation of ICAM-1 expression.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Down-Regulation; Female; Gastric Mucosa; Indomethacin; Intercellular Adhesion Molecule-1; Mice; Mice, Inbred ICR; Neutrophil Activation; Quinolones; Up-Regulation | 2005 |
Terminal-restriction fragment length polymorphism (T-RFLP) analysis for changes in the gut microbiota profiles of indomethacin- and rebamipide-treated mice.
Topics: Alanine; Animals; Cecum; Disease Models, Animal; DNA, Bacterial; Drug Therapy, Combination; Female; Gastrointestinal Tract; Ileum; Indomethacin; Metagenome; Mice; Mice, Inbred C57BL; Polymorphism, Restriction Fragment Length; Quinolones | 2012 |
Rebamipide ameliorates indomethacin-induced small intestinal injury in rats via the inhibition of matrix metalloproteinases activity.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemokines; Down-Regulation; Indomethacin; Injections, Subcutaneous; Intestinal Mucosa; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Metallothionein; Quinolones; Rats; Rats, Wistar; Up-Regulation | 2012 |
Rebamipide inhibits indomethacin-induced small intestinal injury: possible involvement of intestinal microbiota modulation by upregulation of α-defensin 5.
Topics: Alanine; alpha-Defensins; Animals; DNA, Bacterial; Gastrointestinal Agents; Indomethacin; Intestine, Small; Metagenome; Mice; Mice, Inbred C57BL; Quinolones; Up-Regulation | 2013 |
Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents.
Topics: Alanine; Animals; Anti-Ulcer Agents; Artemisia; Coumarins; Ethanol; Hydrochloric Acid; Indomethacin; Male; Phytotherapy; Plant Extracts; Quinolones; Rats, Sprague-Dawley; Stomach Ulcer | 2015 |
[Evaluation of Gastric Mucosal Injury Model Animals of Rebamipide Formulation--Study of Therapeutic Equivalence].
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Disease Models, Animal; Drug Compounding; Drugs, Generic; Gastric Mucosa; Indomethacin; Lipid Peroxides; Male; Quinolones; Rats, Wistar; Stomach Ulcer; Therapeutic Equivalency | 2016 |
Complementarity of in vitro and in vivo models for the evaluation of gastro-protective effects of pharmacological substances.
Topics: Alanine; Animals; Anti-Ulcer Agents; Cimetidine; Dose-Response Relationship, Drug; Gastric Mucosa; Indomethacin; L-Lactate Dehydrogenase; Male; Mitochondria; Quinolones; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Sucralfate | 2017 |
Using human iPS cell-derived enterocytes as novel in vitro model for the evaluation of human intestinal mucosal damage.
Topics: Alanine; Animal Testing Alternatives; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Membrane Permeability; Cells, Cultured; Enterocytes; Humans; Indomethacin; Induced Pluripotent Stem Cells; Microfilament Proteins; Mucin-2; Quinolones | 2018 |
Solid Nanocrystals of Rebamipide Promote Recovery from Indomethacin-Induced Gastrointestinal Bleeding.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Gastrointestinal Hemorrhage; Indomethacin; Intestinal Mucosa; Male; Nanoparticles; Nitric Oxide; Quinolones; Rats; X-Ray Diffraction | 2019 |
Rebamipide ameliorates indomethacin-induced small intestinal damage and proton pump inhibitor-induced exacerbation of this damage by modulation of small intestinal microbiota.
Topics: Alanine; Animals; Anti-Ulcer Agents; Gastrointestinal Microbiome; Indomethacin; Intestinal Mucosa; Intestine, Small; Male; Mice; Proton Pump Inhibitors; Quinolones | 2021 |
Engineering a Remedy to Modulate and Optimize Biopharmaceutical Properties of Rebamipide by Synthesizing New Cocrystal: In Silico and Experimental Studies.
Topics: Alanine; Animals; Biological Availability; Biological Products; Carrageenan; Chemical Engineering; Chemistry, Pharmaceutical; Crystallization; Disease Models, Animal; Drug Compounding; Edema; Humans; Hydrogen Bonding; Indomethacin; Male; Powder Diffraction; Quinolones; Rats; Spectroscopy, Fourier Transform Infrared; Stomach Ulcer | 2021 |