indomethacin has been researched along with glyburide in 169 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.59) | 18.7374 |
| 1990's | 50 (29.59) | 18.2507 |
| 2000's | 74 (43.79) | 29.6817 |
| 2010's | 39 (23.08) | 24.3611 |
| 2020's | 5 (2.96) | 2.80 |
| Authors | Studies |
|---|---|
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Bergström, CA; Hubatsch, I; Johansson, K; Wassvik, CM | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P | 1 |
| Sen, S; Sinha, N | 1 |
| Barton, P; Luker, T; Wenlock, MC | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL | 1 |
| Chang, G; Mathialagan, S; Ryu, S; Varma, MVS; Woody, N | 1 |
| Calder, JA; Schachter, M; Sever, PS | 1 |
| Akata, T; Kuriyama, H; Nakashima, M | 1 |
| Bolofo, ML; Giles, H; Martin, GR | 1 |
| Benedito, S; Nyborg, NC; Prieto, D | 1 |
| De Marte, J; Perreault, T | 1 |
| Calixto, JB; Guimarães, CL; Rae, GA | 1 |
| Shikada, K; Tanaka, S; Yamamoto, A | 1 |
| Kato, R; Nakadate, T; Nakaki, T; Yamamoto, S | 1 |
| Dai, HB; Lowenstein, E; Park, KW; Sellke, FW | 1 |
| Mizusawa, H; Omote, M | 1 |
| Dai, HB; Piana, RN; Sellke, FW; Shafique, T | 1 |
| Mehta, JL; Yang, BC | 1 |
| Hatake, K; Hishida, S; Wakabayashi, I | 1 |
| Mellemkjaer, S; Nielsen-Kudsk, JE | 1 |
| Martin, PL; Potts, AA | 1 |
| Aizawa, H; Hamano, S; Hara, N; Hirata, M; Ikeda, S; Inoue, R; Ito, Y; Matsumoto, K; Xie, Z | 1 |
| Mombouli, JV; Nakashima, M; Taylor, AA; Vanhoutte, PM | 1 |
| Malik, AB; Pinheiro, JM | 1 |
| Kalsner, S | 1 |
| Bari, F; Busija, DW; Errico, RA; Louis, TM; Meng, W | 1 |
| Ando, J; Inukai, M; Kato, M; Kawaguchi, H; Korenaga, R; Miyamoto, M; Sakamoto, A; Shimamoto, N; Shin, WS; Toyo-oka, T; Uehara, Y; Wang, Y | 1 |
| Erdemli, O; Gumusel, B; Sahin-Erdemli, I; Tel, BC | 1 |
| Bharadwaj, LA; Prasad, K | 1 |
| Caldwell, WM; Jimenez, AH; Myers, PR; Tanner, MA | 1 |
| Ayajiki, K; Kangawa, K; Okamura, T; Toda, N | 1 |
| Kamata, K; Kondoh, H | 1 |
| Flavahan, NA; Liu, Q | 1 |
| Kübler, W; Niroomand, F; Tiefenbacher, CP; Tillmanns, H; Zimmermann, R | 1 |
| Horimoto, N; Nabekura, J; Ogawa, T | 1 |
| Chilian, WM; Tiefenbacher, CP | 1 |
| Akar, F; Aşlamaci, S; Kanzik, I; Köksoy, C; Tufan, H; Uydeş-Dogan, BS | 1 |
| Ishizaka, H; Kuo, L | 1 |
| Boels, PJ; Deutsch, J; Gao, B; Haworth, SG | 1 |
| Ito, T; Mokuno, S; Murase, K; Okumura, K; Shinoda, M; Toki, Y | 1 |
| Horibe, M; Murray, PA; Seki, S | 1 |
| Cheung, PY; Schulz, R | 1 |
| Mackert, JL; Parsons, AA; Schilling, L; Wahl, M | 1 |
| Dumont, L; Fontaine, E; Jasmin, G; Véronneau, M; Viau, S | 1 |
| Badzyńska, B; Dobrowolski, L; Kompanowska-Jezierska, E; Sadowski, J; Walkowska, A | 1 |
| Keef, KD; Mutafova-Yambolieva, VN | 1 |
| Alonso, MJ; González, R; Marín, J; Martínez-Orgado, J; Rodríguez-Martínez, MA; Sánchez-Ferrer, CF | 1 |
| de Vroomen, M; Gournay, V; Heymann, MA; Roman, C; Rudolph, AM; Takahashi, Y | 1 |
| Chatterjee, K; Chou, TM; DeMarco, T; Hutchison, SJ; Ko, E; Pothireddy, MR; Protter, AA; Sudhir, K; Zellner, C | 1 |
| Sekiguchi, F; Shimamura, K; Sunano, S; Tanaka, S; Watanabe, H | 1 |
| Abban, G; Akar, F; Buharalioğlu, CK; Heinemann, A; Holzer, P; Uydeş-Doğan, BS; Van de Voorde, J | 1 |
| Ayhan, IH; Ergün, H; Tulunay, FC | 1 |
| Otsuka, A; Shigenobu, K; Tanaka, H; Tanaka, Y | 1 |
| Caligiuri, G; Hansson, GK; Jiang, J; Pernow, J; Thorén, P | 1 |
| Hempelmann, RG; Mehdorn, HM; Pradel, RH; Ziegler, A | 1 |
| Bakhtiarian, A; Djahanguiri, B; Rahgozar, M; Toroudi, HP | 1 |
| Heinemann, A; Horina, G; Pieber, D; Pieber, TR; Sandner-Kiesling, A | 1 |
| Bouchard, JF; Chouinard, J; Lamontagne, D | 1 |
| Callingham, BA; Crosbie, AE; Latimer, RD; Ritchie, AJ; Vuylsteke, A | 1 |
| Coleman, HA; Parkington, HC; Tare, M | 1 |
| Bari, F; Busija, DW; Shimizu, K | 1 |
| Cole, WC; Dong, H; Jiang, Y; Triggle, CR | 1 |
| De Vroomen, M; Heymann, MA; Roman, C; Takahashi, Y | 1 |
| Matsuyama, H; Takewaki, T; Thapaliya, S | 1 |
| Browne, A; Engler, MB; Engler, MM; Sievers, R; Sun, YP | 1 |
| Ralevic, V | 1 |
| Hammer, LW; Hester, RL; Ligon, AL | 1 |
| Amatyakul, S; Niimi, H; Patumraj, S | 1 |
| Bakhtiarian, A; Djahanguiri, B; Pazokitoroudi, H; Rahgozar, M | 1 |
| Chung, WW; Fujita, S; Heisner, JS; Stowe, DF | 1 |
| Mizuno, R; Ohhashi, T; Ono, N | 1 |
| Edwards, G; Félétou, M; Gardener, MJ; Glen, CD; Richards, GR; Vanhoutte, PM; Weston, AH | 1 |
| Koenig, HM; Pelligrino, DA; Santizo, RA; Xu, HL | 1 |
| Grbović, L; Pesić, S; Prostran, M; Radenković, M | 1 |
| Boachie-Ansah, G; Grainger, J | 1 |
| Mizuno, R; Nakaya, K; Ohhashi, T | 1 |
| Kerkhof, CJ; Sipkema, P; Van Der Linden, PJ | 1 |
| Busija, DW; Miller, AW; Puskar, M; Tulbert, C | 1 |
| Abebe, W; Maddux, WF; Mozaffari, MS; Schuster, GS | 1 |
| El-Mahmoudy, A; Matsuyama, H; Shimizu, Y; Takewaki, T; Thapaliya, S | 1 |
| Ago, T; Ibayashi, S; Iida, M; Kamouchi, M; Kitazono, T; Ooboshi, H; Santa, N; Wakisaka, M | 1 |
| de Hoon, JN; Pickkers, P; Smits, P; Struijker-Boudier, HA; Van Bortel, LM | 1 |
| Krylatov, AV; Lishmanov, YB; Maslov, LN; Solenkova, NV; Stakheev, DL | 1 |
| Hosaka, K; Mizuno, R; Ohhashi, T | 1 |
| Evora, PR; Pearson, PJ; Rodrigues, AJ; Schaff, HV | 1 |
| Abebe, W; Lewis, JB; Maddux, WF; Schuster, GS | 1 |
| Kendall, DA; Randall, MD; Tep-areenan, P | 1 |
| Alves, DP; Duarte, ID; Leite, R; Tatsuo, MA | 1 |
| Hellige, G; Klockgether-Radke, AP; Neumann, P; Schulze, H | 1 |
| Barişkaner, H; Doğan, N; Kiliç, M; Otelcioğlu, S; Tuncer, S; Yosunkaya, A | 1 |
| Bagorda, A; Calamita, G; Casavola, V; Fanelli, T; Favia, M; Guerra, L; Jacobson, KA; Reshkin, SJ; Svetlo, M | 1 |
| Ikomi, F; Kousai, A; Mizuno, R; Ohhashi, T | 1 |
| Gendron, ME; Perrault, LP; Thorin, E | 1 |
| Carvalho, LC; de Moura, RS; Madeira, SV; Miranda, DZ; Pinto, AC; Rangel, BM; Resende, AC; Rubenich, LM; Sicca, RF; Souza, MA; Tano, T | 1 |
| Chemtob, S; Clyman, RI; Fouron, JC; Ginzinger, D; Kajino, H; Marrache, AM; Moss, TJ; Roman, C; Seidner, SR; Vazquez-Tello, A; Waleh, N | 1 |
| Abdelrahman, AM; Pang, CC; Syyong, HT; Tjahjadi, AA | 1 |
| Qiu, Y; Quilley, J | 1 |
| Campbell, WB; Falck, JR; Gauthier, KM; Nithipatikom, K; Reddy, LM; Sangras, B; Sharma, KK; Yang, W | 1 |
| Hellige, G; Klockgether-Radke, AP; Neumann, P; Pawlowski, P | 1 |
| Hellige, G; Huneck, S; Klockgether-Radke, AP; Meyberg, S; Neumann, P | 1 |
| Butler, JM; Forster, AH; James, MB; Lancaster, RW; Patterson, JE; Rades, T | 1 |
| Hosaka, K; Imtiaz, MS; Rayner, SE; van Helden, DF; von der Weid, PY; Zhao, J | 1 |
| Cao, LH; Choi, DH; Kang, DG; Kim, JS; Kim, SJ; Lee, H; Lee, HS; Lee, JK | 1 |
| Cunha, FQ; Gomes, AS; Lima, LM; Ribeiro, RA; Santos, CL; Souza, MH | 1 |
| Brito, GA; Cunha, FQ; de Souza, MH; Lemos, HP; Menezes, AA; Mota, JM; Ribeiro, RA; Soares, PM | 1 |
| Seyrek, M; Ulusoy, HB; Yildirim, V; Yildiz, O | 1 |
| Huang, ZQ; Xu, HB | 1 |
| Ishii, K; Kametaka, S; Mori, A; Nakahara, T; Ogawa, N; Saito, M; Sakamoto, K | 1 |
| Bagcivan, I; Gursoy, S; Kaya Temiz, T; Turan, M; Yildirim, MK; Yildirim, S; Yilmaz, A | 1 |
| Birkenmeier, K; Felix, SB; Janke, I; Krieg, T; Labitzke, C; Landsberger, M; Prange, T; Schunck, WH; Stangl, V; Staudt, A; Trimpert, C | 1 |
| Félétou, M; Leuranguer, V; Vanhoutte, PM; Verbeuren, T | 1 |
| de Olinda, TM; Lemos, TL; Machado, LL; Rao, VS; Santos, FA | 1 |
| Fouad, AA; Morsy, MA | 1 |
| Carvalho, AC; de Queiroz, SS; Guedes, MM; Lima, AF; Lira, SR; Rao, VS; Santos, FA; Silveira, ER | 1 |
| Li, J; Liang, Y; Niu, L; Wu, D; Xue, W; Zhang, M | 1 |
| Basak, F; Cehreli, SB; Cehreli, ZC; Guven, G; Kaya, E; Seyrek, M; Ulku, C; Vural, IM; Yildiz, O | 1 |
| Anger, G; Gedeon, C; Koren, G; Lubetsky, A; Miller, MP | 1 |
| Campos, AR; da Costa, JG; da Penha, AR; de O Leite, G; Fernandes, CN; Souza, HH | 1 |
| Chen, J; Chen, X; Liu, J; Wang, T; Xiao, H; Yang, J; Ye, Z; Yin, C | 1 |
| Achike, FI; Mustafa, MR; Subramaniam, G | 1 |
| Bankar, GR; Bhattacharya, S; Nampurath, GK; Nayak, PG | 1 |
| Albuquerque, RL; de Andrade, GM; de Morais, SM; de Souza, CM; Rao, VS; Rodrigues, Pde A; Santos, FA; Silva, AR; Silva, MG | 1 |
| Lim, YL; Mok, SL | 1 |
| Aihara, E; Hayashi, S; Ise, F; Koyama, M; Takahashi, K; Takasuka, H; Takeuchi, K | 1 |
| Achike, FI; Tan, BT; Yeo, JL | 1 |
| Bertini, S; Gianelli, P; Menozzi, A; Passeri, B; Poli, E; Pozzoli, C | 1 |
| Krishnamurthy, S; Saxena, B; Singh, S | 1 |
| Cehreli, ZC; Guven, G; Seyrek, M; Vural, IM; Yildiz, O | 1 |
| Bertelli, E; Dragoni, S; Franco, G; Frosini, M; Gori, M; Possidente, M; Teodori, E; Valoti, M | 1 |
| Annaert, P; Augustijns, P; Martens, JA; Mellaerts, R; Thi, TD; Van den Mooter, G; Van Humbeeck, J; van Speybroeck, M | 1 |
| Araújo Castro, C; Coelho de Souza, G; de Azevedo Moreira, R; de Oliveira Monteiro-Moreira, AC; de Vasconcellos Abdon, AP; Moreira Guedes, M; Noronha Coelho de Souza, L; Pereira Lima, RC; Prado Vasconcelos, R; Rolim Campos, A | 1 |
| Fujiwara, H; Hashikawa-Hobara, N; Kawasaki, H; Kitamura, Y; Makino, K; Takatori, S; Wake, Y; Zamami, Y | 1 |
| Barahona, MV; Bustamante, S; Carballido, J; Fernandes, VS; García-Sacristán, A; Hernández, M; Martínez, AC; Martínez-Sáenz, A; Orensanz, LM; Prieto, D; Recio, P; Ribeiro, AS | 1 |
| Suksamrarn, S; Tep-Areenan, P | 1 |
| Bednarski, M; Bilska-Wilkosz, A; Bugajski, D; Dudek, M; Filipek, B; Iciek, M; Knutelska, J; Mogilski, S; Sapa, J; Włodek, L; Zygmunt, M | 1 |
| García, M; García-Pedraza, JÁ; Martín, ML; Morán, A; San Román, L | 1 |
| Fahim, M; Muralidhar, K; Saidullah, B | 1 |
| Balogun, SO; Damazo, AS; de Oliveira Martins, DT | 1 |
| Ji, Y; Paus, R; Sadowski, G; Vahle, L | 1 |
| Lobov, GI; Pan'kova, MN | 1 |
| Antonisamy, P; Arasu, MV; Aravinthan, A; Choi, KC; Dhanasekaran, M; Kang, CW; Kim, JH; Kim, NS | 1 |
| Aguilar-Carrasco, JC; Castillo-Henkel, EF; López-Canales, JS; López-Canales, OA; López-Mayorga, RM; Lozano-Cuenca, J; Villagrana-Zesati, JR | 1 |
| Coutinho, HD; de Albuquerque, TR; de Lacerda Neto, LJ; de Menezes, IR; de Oliveira, LR; de Souza, SD; Dos Santos, AT; Kerntopf, MR; Quintans-Júnior, LJ; Ramos, AG; Santos Sales, V; Wanderley, AG | 1 |
| Bano, S; Kambadur, M; Mohammad, F; Swati, O | 1 |
| Abreu-Villela, R; Adler, C; Caraballo, I; Kuentz, M | 1 |
| Chandrasekaran, G; Kumar, D; Kumar, T; Mahobiya, A; Parida, S; Rungsung, S; Singh, TU | 1 |
| Gaber, SS; Rofaeil, RR | 1 |
| Dell'Orco, PC; Floyd, PD; Skrdla, PJ | 1 |
| Antunes, E; Britto-Júnior, J; Campos, R; De Nucci, G; Figueiredo Murari, GM; Jacintho, FF; Mónica, FZ; Moreno, RA | 1 |
| Ferrero-Andrés, A; Folch-Puy, E; Panisello-Roselló, A; Roselló-Catafau, J | 1 |
| Sahinturk, S | 1 |
2 review(s) available for indomethacin and glyburide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
NLRP3 Inflammasome-Mediated Inflammation in Acute Pancreatitis.
Topics: Animals; Anti-Inflammatory Agents; Gene Expression Regulation; Glyburide; Humans; Indomethacin; Inflammasomes; Inflammation; Interleukin-18; Interleukin-1beta; Myeloid Differentiation Factor 88; NLR Family, Pyrin Domain-Containing 3 Protein; Pancreas; Pancreatitis; Signal Transduction; Toll-Like Receptor 3; Withanolides | 2020 |
1 trial(s) available for indomethacin and glyburide
| Article | Year |
|---|---|
Calcitonin gene-related peptide: exploring its vasodilating mechanism of action in humans.
Topics: Adult; Brachial Artery; Calcitonin Gene-Related Peptide; Drug Interactions; Female; Glyburide; Hemodynamics; Humans; Indomethacin; Infusions, Intra-Arterial; Male; omega-N-Methylarginine; Plethysmography; Potassium Channels; Tetraethylammonium; Vasodilation | 2003 |
166 other study(ies) available for indomethacin and glyburide
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Identification and prediction of promiscuous aggregating inhibitors among known drugs.
Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship | 2003 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Poorly soluble marketed drugs display solvation limited solubility.
Topics: Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Molecular Structure; Multivariate Analysis; Pharmaceutical Preparations; Principal Component Analysis; Solubility; Tandem Mass Spectrometry; Thermodynamics | 2007 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.
Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design.
Topics: Acids; Albumins; Drug Design; Humans; Hydrogen-Ion Concentration; Lipids; Molecular Structure; Pharmaceutical Preparations; Protein Binding | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat | 2016 |
Identification of Organic Anion Transporter 2 Inhibitors: Screening, Structure-Based Analysis, and Clinical Drug Interaction Risk Assessment.
Topics: Drug Interactions; HEK293 Cells; Humans; Liver; Organic Anion Transporters, Sodium-Independent; Risk Assessment | 2022 |
Mechanisms of action of cicletanine in human and guinea pig resistance arteries.
Topics: Animals; Antihypertensive Agents; Arteries; Charybdotoxin; Diuretics; Drug Interactions; Eicosanoids; Glyburide; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Kinetics; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium; Potassium Channels; Pyridines; Scorpion Venoms; Tetraethylammonium; Tetraethylammonium Compounds; Vascular Resistance | 1992 |
Effects on the rabbit coronary artery of LP-805, a new type of releaser of endothelium-derived relaxing factor and a K+ channel opener.
Topics: Acetylcholine; Action Potentials; Animals; Coronary Vessels; Glyburide; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Potassium Channels; Pyrazoles; Pyrimidines; Rabbits; Vasodilator Agents | 1992 |
Inhibition of endothelium-dependent vasorelaxation by arginine analogues: a pharmacological analysis of agonist and tissue dependence.
Topics: Acetylcholine; Alkylation; Animals; Aorta, Thoracic; Arginine; Glyburide; In Vitro Techniques; Indomethacin; Jugular Veins; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Parasympatholytics; Piperidines; Rabbits; Receptors, Muscarinic; Receptors, Serotonin; Serotonin Antagonists | 1992 |
Heterogeneous involvement of endothelium in calcitonin gene-related peptide-induced relaxation in coronary arteries from rat.
Topics: Acetylcholine; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Coronary Vessels; Endothelium, Vascular; Glyburide; Humans; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Muscle Relaxation; Muscle Tonus; Muscle, Smooth, Vascular; Rats; Rats, Inbred Strains; Ruthenium Red; Substance P | 1991 |
Endothelin-1 has a dilator effect on neonatal pig pulmonary vasculature.
Topics: Animals; Animals, Newborn; Arginine; Dose-Response Relationship, Drug; Endothelins; Glyburide; In Vitro Techniques; Indomethacin; Nitroarginine; Organ Size; Perfusion; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Pulmonary Circulation; Swine; Vasodilation | 1991 |
Potent constrictor actions of endothelin-1, endothelin-2, and endothelin-3 in rat isolated portal vein.
Topics: Alkaloids; Animals; Benzopyrans; Calcium; Cromakalim; Endothelins; Glyburide; Indomethacin; Male; Mesenteric Veins; Nicardipine; Phorbols; Portal Vein; Protein Kinase C; Pyrroles; Rats; Rats, Inbred Strains; Staurosporine; Vasoconstriction; Vasodilator Agents | 1992 |
NIP-121 and cromakalim, potassium channel openers, preferentially suppress prostanoid-induced contraction of the guinea-pig isolated trachea.
Topics: Animals; Arachidonic Acid; Benzopyrans; Cromakalim; Dinoprost; Glyburide; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Oxadiazoles; Piperidines; Potassium Channels; Prostaglandin D2; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Pyrroles; Sulfonamides; Trachea | 1991 |
Possible involvement of phospholipase A2 activation and lipoxygenase product(s) in the mechanism of insulin secretion.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Arginine; Enzyme Activation; Glucose; Glyburide; In Vitro Techniques; Indomethacin; Insulin; Insulin Secretion; Islets of Langerhans; Lipoxygenase; Lysophosphatidylcholines; Male; Phospholipases; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains | 1983 |
Propofol-associated dilation of rat distal coronary arteries is mediated by multiple substances, including endothelium-derived nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anesthetics, Intravenous; Animals; Arginine; Coronary Vessels; Cyclooxygenase Inhibitors; Endothelium, Vascular; Female; Glyburide; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Potassium Channel Blockers; Potassium Channels; Propofol; Prostaglandin Endoperoxides, Synthetic; Prostaglandins; Rats; Rats, Wistar; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Phenylephrine-induced rhythmic activity in the rabbit ear artery.
Topics: Animals; Arginine; Arteries; Charybdotoxin; Ear, External; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Male; Nifedipine; Nitric Oxide; Nitroarginine; omega-N-Methylarginine; Periodicity; Phenylephrine; Potassium Channel Blockers; Prostaglandin Antagonists; Rabbits; Scorpion Venoms; Vasoconstriction | 1993 |
Epicardial and endocardial coronary microvascular responses: effects of ischemia-reperfusion.
Topics: Adenosine; Animals; Arginine; Bradykinin; Calcimycin; Coronary Circulation; Endocardium; Endothelium, Vascular; Female; Glyburide; Guanylate Cyclase; Indomethacin; Male; Microcirculation; Muscle, Smooth, Vascular; Nitroprusside; omega-N-Methylarginine; Reperfusion Injury; Serotonin; Swine | 1994 |
Critical role of endothelium in sustained arterial contraction during prolonged hypoxia.
Topics: Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Aorta, Thoracic; Arginine; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Indomethacin; Nitric Oxide Synthase; Nitroarginine; omega-N-Methylarginine; Oxyhemoglobins; Potassium Channel Blockers; Potassium Channels; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 1995 |
Endothelium-dependent relaxation resistant to NG-nitro-L-arginine in rat aorta.
Topics: Acetylcholine; Analysis of Variance; Animals; Aorta, Thoracic; Arginine; Atropine; Biological Factors; Cyclic GMP; Endothelium, Vascular; Glyburide; Indomethacin; Isometric Contraction; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Oxyhemoglobins; Papaverine; Potassium Channel Blockers; Rats; Rats, Wistar; Tetraethylammonium; Tetraethylammonium Compounds | 1995 |
Glibenclamide inhibits hypoxic relaxation of isolated porcine coronary arteries under conditions of impaired glycolysis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenosine Triphosphate; Animals; Benzopyrans; Coronary Vessels; Cromakalim; Deoxyglucose; Endothelium, Vascular; Glyburide; Glycolysis; Hypoxia; In Vitro Techniques; Indomethacin; Isometric Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Swine; Theophylline; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1994 |
The endothelium of the rat renal artery plays an obligatory role in A2 adenosine receptor-mediated relaxation induced by 5'-N-ethylcarboxamidoadenosine and N6-cyclopentyladenosine.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Arginine; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Isoproterenol; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Renal Artery; Renal Circulation; Theophylline; Vasodilator Agents; Xanthines | 1994 |
Effects of epithelial cell supernatant on membrane potential and contraction of dog airway smooth muscles.
Topics: Animals; Arginine; Bronchi; Cells, Cultured; Dogs; Electrophysiology; Epithelial Cells; Epithelium; Glyburide; Indomethacin; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Nitroarginine; Oxyhemoglobins; Trachea | 1994 |
Endothelium-dependent hyperpolarization caused by bradykinin in human coronary arteries.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Arginine; Benzopyrans; Bradykinin; Calcimycin; Child; Coronary Vessels; Cromakalim; Dinoprost; Endothelium, Vascular; Glyburide; Humans; In Vitro Techniques; Indoles; Indomethacin; Infant; Male; Membrane Potentials; Middle Aged; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Pyrroles; Vasodilator Agents | 1993 |
Mechanisms of endothelin-1-induced pulmonary vasodilatation in neonatal pigs.
Topics: Animals; Animals, Newborn; Arginine; Endothelins; Female; Glyburide; Hemoglobins; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; omega-N-Methylarginine; Peptide Fragments; Perfusion; Potassium Channels; Pulmonary Circulation; Receptors, Endothelin; Swine; Vasodilation | 1993 |
Hypoxic relaxation in functionally intact cattle coronary artery segments involves K+ ATP channels.
Topics: Adenosine; Adenosine Triphosphate; Animals; Arteries; Calcium; Calcium Channel Blockers; Cattle; Coronary Vessels; Glyburide; Guanidines; Hypoxia; In Vitro Techniques; Indomethacin; Muscle Relaxation; Pinacidil; Potassium Channel Blockers; Potassium Channels; Rabbits; Tetrodotoxin; Vasodilator Agents | 1995 |
Ischemia reduces CGRP-induced cerebral vascular dilation in piglets.
Topics: Animals; Animals, Newborn; Antioxidants; Arterioles; Calcitonin Gene-Related Peptide; Cerebral Arteries; Cyclooxygenase Inhibitors; Female; Glyburide; Indomethacin; Ischemic Attack, Transient; Male; Potassium Channel Blockers; Prostaglandin-Endoperoxide Synthases; Reactive Oxygen Species; Reperfusion; Reperfusion Injury; Superoxides; Swine; Vasodilation; Vasodilator Agents | 1996 |
Contribution of sustained Ca2+ elevation for nitric oxide production in endothelial cells and subsequent modulation of Ca2+ transient in vascular smooth muscle cells in coculture.
Topics: Animals; Aorta; Arginine; Bradykinin; Calcium; Calcium-Transporting ATPases; Cattle; Cells, Cultured; Chelating Agents; Coculture Techniques; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Indomethacin; Ionomycin; Kinetics; Muscle, Smooth, Vascular; Nickel; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Terpenes; Thapsigargin; Time Factors | 1996 |
The pulmonary vascular response to propofol in the isolated perfused rat lung.
Topics: Anesthetics, Intravenous; Animals; Arginine; Blood Pressure; Blood Vessels; Calcium; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Indomethacin; Lung; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Potassium; Potassium Channel Blockers; Potassium Channels; Propofol; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 1995 |
Mechanism of hydroxyl radical-induced modulation of vascular tone.
Topics: Animals; Aorta; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hydroxyl Radical; Indomethacin; Mannitol; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Norepinephrine; omega-N-Methylarginine; Rabbits | 1997 |
Effects of oxygen tension on flow-induced vasodilation in porcine coronary resistance arterioles.
Topics: Animals; Arterioles; Bradykinin; Cell Hypoxia; Coronary Vessels; Drug Synergism; Endothelium, Vascular; Female; Glyburide; Hemorheology; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxygen; Partial Pressure; Swine; Vasodilation; Vasodilator Agents; Vasomotor System | 1996 |
Mechanism of adrenomedullin-induced relaxation in isolated canine retinal arteries.
Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Cyclic AMP; Cyclic GMP; Cyclooxygenase Inhibitors; Dogs; Endothelium, Vascular; Enzyme Inhibitors; Female; Glyburide; Hypoglycemic Agents; Indomethacin; Male; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Peptides; Retinal Artery; Vasodilator Agents | 1997 |
Impairment of endothelium-dependent relaxation of the isolated basilar artery from streptozotocin-induced diabetic rats.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Basilar Artery; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Indomethacin; Male; Muscle Relaxation; Nitroarginine; Nitroprusside; Potassium; Rats; Rats, Wistar; Vasodilator Agents | 1996 |
Hypoxic dilatation of porcine small coronary arteries: role of endothelium and KATP-channels.
Topics: Animals; Benzopyrans; Cell Hypoxia; Coronary Vessels; Cromakalim; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Channels; Pyrroles; Swine; Vasodilation | 1997 |
Adaptation of myocardial blood flow to increased metabolic demand is not dependent on endothelial vasodilators in the rat heart.
Topics: Acetylcholine; Adaptation, Physiological; Adrenergic beta-1 Receptor Agonists; Animals; Coronary Circulation; Cyclooxygenase Inhibitors; Dobutamine; Female; Glyburide; Indomethacin; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Perfusion; Potassium Channels; Rats; Rats, Wistar; Regional Blood Flow; Vasodilator Agents | 1997 |
Arachidonic acid activation of potassium channels in rat visual cortex neurons.
Topics: 4-Aminopyridine; Animals; Apamin; Arachidonic Acid; Barium; Charybdotoxin; Docosahexaenoic Acids; Egtazic Acid; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Glyburide; In Vitro Techniques; Indomethacin; Membrane Potentials; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Quinidine; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Tetraethylammonium Compounds; Visual Cortex | 1997 |
Basic fibroblast growth factor and heparin influence coronary arteriolar tone by causing endothelium-dependent dilation.
Topics: Animals; Antibodies, Monoclonal; Coronary Vessels; Dose-Response Relationship, Drug; Endothelium, Vascular; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2; Glyburide; Heparin; In Vitro Techniques; Indomethacin; Microscopy, Video; Nitric Oxide Synthase; omega-N-Methylarginine; Potassium Channels; Receptors, Fibroblast Growth Factor; Swine; Vasodilation | 1997 |
The comparison of the responsiveness of human isolated internal mammary and gastroepiploic arteries to levcromakalim: an alternative approach to the management of graft spasm.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arteries; Benzopyrans; Coronary Artery Bypass; Cromakalim; Endothelin-1; Female; Glyburide; Humans; In Vitro Techniques; Indomethacin; Male; Mammary Arteries; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroarginine; Norepinephrine; Omentum; Potassium; Potassium Channel Blockers; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Stomach; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents | 1997 |
Endothelial ATP-sensitive potassium channels mediate coronary microvascular dilation to hyperosmolarity.
Topics: Animals; Apamin; Arterioles; Clotrimazole; Coronary Circulation; Cytochrome P-450 Enzyme Inhibitors; Endothelium, Vascular; Glucose; Glyburide; Hypertonic Solutions; In Vitro Techniques; Indomethacin; Kinetics; Microcirculation; NG-Nitroarginine Methyl Ester; Nitroprusside; Peptides; Potassium Channels; Potassium Chloride; Sucrose; Swine; Vasodilation | 1997 |
ATP-dependent K+ channel activation in isolated normal and hypertensive newborn and adult porcine pulmonary vessels.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Antihypertensive Agents; Cromakalim; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium; Enzyme Inhibitors; Female; Glyburide; Hypertension, Pulmonary; Hypoglycemic Agents; Hypoxia; In Vitro Techniques; Indomethacin; omega-N-Methylarginine; Potassium Channel Blockers; Potassium Channels; Prostaglandins; Pulmonary Artery; Pulmonary Veins; Sensitivity and Specificity; Swine | 1997 |
Types of potassium channels involved in coronary reactive hyperemia depend on duration of preceding ischemia in rat hearts.
Topics: 4-Aminopyridine; Adenosine Diphosphate; Animals; Apamin; Charybdotoxin; Glyburide; Hyperemia; In Vitro Techniques; Indomethacin; Male; Myocardial Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Potassium Channels; Rats; Rats, Wistar; Regional Blood Flow; Tetraethylammonium; Tetraethylammonium Compounds | 1997 |
Halothane attenuates endothelium-dependent pulmonary vasorelaxant response to lemakalim, an adenosine triphosphate (ATP)-sensitive potassium channel agonist.
Topics: Adenosine Triphosphate; Anesthetics, Inhalation; Animals; Benzopyrans; Cromakalim; Dogs; Endothelium, Vascular; Glyburide; Halothane; Humans; Indomethacin; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Potassium Channels; Pulmonary Artery; Pyrroles; Vasodilation; Vasodilator Agents | 1997 |
Glutathione causes coronary vasodilation via a nitric oxide- and soluble guanylate cyclase-dependent mechanism.
Topics: Analysis of Variance; Animals; Blood Pressure; Carmustine; Coronary Circulation; Coronary Vessels; Enzyme Inhibitors; Glutathione; Glutathione Disulfide; Glyburide; Guanylate Cyclase; Heart; Heart Rate; In Vitro Techniques; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Superoxide Dismutase; Vasodilation; Ventricular Function, Left | 1997 |
Mediation of endothelium-dependent relaxation: different response patterns in rat and rabbit basilar artery.
Topics: Acetylcholine; Animals; Basilar Artery; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Nitric Oxide Synthase; Nitroarginine; Rabbits; Rats; Vasodilation | 1997 |
Myocardial reactive hyperemia in experimental chronic heart failure: evidence for the role of K+ adenosine triphosphate-dependent channels and cyclooxygenase activity.
Topics: Animals; Cardiac Output, Low; Chronic Disease; Coronary Circulation; Cricetinae; Disease Models, Animal; Enzyme Inhibitors; Glyburide; Hyperemia; Indomethacin; NG-Nitroarginine Methyl Ester; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Theophylline | 1997 |
Simultaneous recording of tissue ion content and blood flow in rat renal medulla: evidence on interdependence.
Topics: Animals; Glyburide; Indomethacin; Ions; Kidney Medulla; Laser-Doppler Flowmetry; Male; Osmolar Concentration; Rats; Rats, Wistar; Regional Blood Flow | 1997 |
Adenosine-induced hyperpolarization in guinea pig coronary artery involves A2b receptors and KATP channels.
Topics: 2-Chloroadenosine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Cell Membrane; Coronary Vessels; Endothelium, Vascular; Glyburide; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Nitroarginine; Potassium Channels; Purinergic P1 Receptor Agonists; Receptor, Adenosine A2B; Receptors, Purinergic P1 | 1997 |
Endothelial factors and autoregulation during pressure changes in isolated newborn piglet cerebral arteries.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cerebral Arteries; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Homeostasis; In Vitro Techniques; Indomethacin; Large-Conductance Calcium-Activated Potassium Channels; NG-Nitroarginine Methyl Ester; Oligopeptides; Peptides, Cyclic; Piperidines; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Pressure; Swine; Tetraethylammonium | 1998 |
Mechanisms of adrenomedullin-induced increase of pulmonary blood flow in fetal sheep.
Topics: Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cromakalim; Cyclooxygenase Inhibitors; Female; Fetus; Glyburide; Indomethacin; Lung; Muscle, Smooth, Vascular; Nitroarginine; Peptide Fragments; Peptides; Potassium Channel Blockers; Pregnancy; Pulmonary Artery; Pulmonary Circulation; Regional Blood Flow; Sheep; Vasodilator Agents | 1999 |
Coronary vasodilator effects of BNP: mechanisms of action in coronary conductance and resistance arteries.
Topics: Animals; Coronary Vessels; Cyclooxygenase Inhibitors; Endothelin-1; Enzyme Inhibitors; Female; Glyburide; Indomethacin; Natriuretic Peptide, Brain; NG-Nitroarginine Methyl Ester; Nitroglycerin; Pericardium; Potassium Channel Blockers; Swine; Vascular Resistance; Vasodilation; Vasodilator Agents | 1999 |
Endothelium-derived relaxing, contracting and hyperpolarizing factors of mesenteric arteries of hypertensive and normotensive rats.
Topics: Acetylcholine; Animals; Apamin; Blood Pressure; Body Weight; Bridged Bicyclo Compounds, Heterocyclic; Charybdotoxin; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glyburide; Hydrazines; Hypertension; In Vitro Techniques; Indomethacin; Membrane Potentials; Mesenteric Arteries; Methylene Blue; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide; Nitroarginine; Nitroprusside; Potassium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Systole; Tetraethylammonium; Vasodilation; Vasodilator Agents | 1999 |
Protective effect of cromakalim and diazoxide, and proulcerogenic effect of glibenclamide on indomethacin-induced gastric injury.
Topics: Animals; Arteries; Blood Glucose; Blood Pressure; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Gastric Mucosa; Gastrointestinal Agents; Glyburide; Hypoglycemic Agents; Indomethacin; Male; Neutrophils; Peroxidase; Rats; Regional Blood Flow; Stomach; Stomach Diseases; Vasodilation; Vasodilator Agents | 1999 |
Pharmacological characterization of metamizol-induced relaxation in phenylephrine-precontracted rabbit thoracic aorta smooth muscle.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Thoracic; Dipyrone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glyburide; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Ouabain; Phenylephrine; Rabbits; Sodium-Potassium-Exchanging ATPase; Tetraethylammonium; Time Factors; Vasoconstrictor Agents | 1999 |
Glycyrrhetinic acid-sensitive mechanism does not make a major contribution to non-prostanoid, non-nitric oxide mediated endothelium-dependent relaxation of rat mesenteric artery in response to acetylcholine.
Topics: Acetylcholine; Animals; Arachidonic Acid; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Glyburide; Glycyrrhetinic Acid; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Phosphodiesterase Inhibitors; Potassium Channel Blockers; Rats; Rats, Wistar | 1999 |
Enhanced phenylephrine-induced rhythmic activity in the atherosclerotic mouse aorta via an increase in opening of KCa channels: relation to Kv channels and nitric oxide.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Aorta; Arteriosclerosis; Calcium; Cholera Toxin; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Indomethacin; Ion Channel Gating; Male; Mice; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Ouabain; Phenylephrine; Potassium Channel Blockers; Potassium Channels; Ryanodine; Tetraethylammonium Compounds | 1999 |
Threshold concentrations of endothelin-1: the effects on contractions induced by 5-hydroxytryptamine in isolated rat cerebral and mesenteric arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Basilar Artery; Biphenyl Compounds; Drug Synergism; Endothelin Receptor Antagonists; Endothelin-1; Glyburide; Heptanoic Acids; Indomethacin; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Pentanoic Acids; Peptides, Cyclic; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin; Vasoconstriction; Vasopressins | 1999 |
Potassium channel modulators and indomethacin-induced gastric ulceration in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Diazoxide; Enalapril; Gastric Mucosa; Glyburide; Hydralazine; Indomethacin; Male; Peptic Ulcer; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasodilator Agents | 1999 |
Pressor and mesenteric arterial hyporesponsiveness to angiotensin II is an early event in haemorrhagic hypotension in anaesthetised rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Benzimidazoles; Benzoates; Blood Pressure; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Glyburide; Hemodynamics; Indomethacin; Male; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Regional Blood Flow; Shock, Hemorrhagic; Telmisartan; Time Factors; Vasoconstrictor Agents | 1999 |
Participation of prostaglandin E2 in the endothelial protective effect of ischaemic preconditioning in isolated rat heart.
Topics: 6-Ketoprostaglandin F1 alpha; Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Coronary Vessels; Cyclooxygenase Inhibitors; Dinoprostone; Endothelium, Vascular; Enzyme Activators; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; Indomethacin; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion Injury; Perfusion; Phenanthridines; Protein Kinase C; Rats; Rats, Sprague-Dawley; Serotonin; Vascular Resistance | 2000 |
Inhibitory effects of glibenclamide on the contraction of human arterial conduits used in coronary artery bypass surgery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Calcium; Coronary Artery Bypass; Dose-Response Relationship, Drug; Glyburide; Humans; In Vitro Techniques; Indomethacin; Mammary Arteries; Phenylephrine; Potassium; Radial Artery; Tolbutamide; Vasoconstriction; Vasoconstrictor Agents | 2000 |
EDHF, NO and a prostanoid: hyperpolarization-dependent and -independent relaxation in guinea-pig arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Biological Factors; Cyclooxygenase Inhibitors; Electrophysiology; Endothelium, Vascular; Enzyme Inhibitors; Female; Glyburide; Guinea Pigs; Hypoglycemic Agents; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Prostaglandins; Vasoconstriction; Vasoconstrictor Agents | 2000 |
Glibenclamide enhances cortical spreading depression-associated hyperemia in the rat.
Topics: Animals; Cerebral Cortex; Charybdotoxin; Cortical Spreading Depression; Glyburide; Hyperemia; Indomethacin; Male; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar | 2000 |
Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels.
Topics: 4-Aminopyridine; Acetylcholine; Animals; Arachidonic Acids; Biological Factors; Cerebral Arteries; Charybdotoxin; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Guinea Pigs; Imidazoles; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Nitric Oxide; Nitroarginine; Ouabain; Oxadiazoles; Potassium Channel Blockers; Potassium Channels; Quinoxalines; Vasodilation; Vasodilator Agents | 2000 |
Mechanisms of calcitonin gene-related peptide-induced increases of pulmonary blood flow in fetal sheep.
Topics: Adenosine Triphosphate; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Cyclooxygenase Inhibitors; Fetus; Glyburide; Indomethacin; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Potassium Channel Blockers; Pulmonary Circulation; Sheep | 2000 |
Bradykinin causes endothelium-independent hyperpolarisation and neuromodulation by prostanoid synthesis in hamster mesenteric artery.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Cricetinae; Dinoprostone; Dose-Response Relationship, Drug; Endothelium, Vascular; Epoprostenol; Glyburide; Iloprost; Indomethacin; Male; Membrane Potentials; Mesenteric Arteries; Mesocricetus; Muscle, Smooth, Vascular; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Potassium Channels; Prostaglandins | 2000 |
Mechanisms of vasorelaxation induced by eicosapentaenoic acid (20:5n-3) in WKY rat aorta.
Topics: Animals; Aorta, Thoracic; Calcium; Dose-Response Relationship, Drug; Egtazic Acid; Eicosapentaenoic Acid; Glyburide; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Norepinephrine; Potassium Channel Blockers; Rats; Rats, Inbred WKY; Tetraethylammonium; Vasoconstriction; Vasodilation | 2000 |
Mechanism of prolonged vasorelaxation to ATP in the rat isolated mesenteric arterial bed.
Topics: Adenosine Triphosphate; Animals; Capsaicin; Cardiotonic Agents; Cardiovascular Agents; Charybdotoxin; Drug Interactions; Electric Stimulation; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Isotonic Solutions; Male; Mesenteric Arteries; Neurons, Afferent; Ouabain; Pyridoxal Phosphate; Rats; Rats, Wistar; Suramin; Tetraethylammonium; Theophylline; Vasodilation | 2001 |
Differential inhibition of functional dilation of small arterioles by indomethacin and glibenclamide.
Topics: Adenosine Triphosphate; Animals; Arterioles; Cricetinae; Cyclooxygenase Inhibitors; Electric Stimulation; Glyburide; Indomethacin; Male; Mesocricetus; Microscopy, Video; Muscles; Nitroprusside; Potassium Channel Blockers; Vasodilation; Venules | 2001 |
Effects of adrenomedullin on the cardiac performance and coronary flow in an isolated perfused rat heart model.
Topics: Adrenomedullin; Animals; Antihypertensive Agents; Cardiovascular Agents; Coronary Circulation; Cyclic AMP; Cyclooxygenase Inhibitors; Electrocardiography; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Heart; Heart Rate; Indomethacin; Ion Transport; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptides; Potassium; Potassium Channels; Rats; Rats, Wistar; Second Messenger Systems; Vasodilator Agents; Ventricular Function, Left | 2000 |
Diazoxide, a K(ATP) opener, accelerates restitution of ethanol or indomethacin-induced gastric ulceration in rats independent of polyamines.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diazoxide; Ethanol; Glyburide; Indomethacin; Male; Polyamines; Potassium Channels; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Wound Healing | 2001 |
Volatile anaesthetics restore bradykinin and serotonin-induced coronary vasodilation after blocking nitric oxide synthase: lack of anaesthetic effects on KATP channels and prostaglandin pathways.
Topics: Anesthetics, Inhalation; Animals; ATP-Binding Cassette Transporters; Bradykinin; Coronary Circulation; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Glyburide; Guinea Pigs; Heart; Hypoglycemic Agents; In Vitro Techniques; Indomethacin; KATP Channels; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Inwardly Rectifying; Prostaglandin Antagonists; Serotonin; Vasodilation | 2001 |
Parathyroid hormone-related protein-(1-34) inhibits intrinsic pump activity of isolated murine lymph vessels.
Topics: Animals; Arginine; Drug Combinations; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Lymphatic System; Male; Mice; NG-Nitroarginine Methyl Ester; Parathyroid Hormone-Related Protein; Penicillamine; Peptide Fragments; Proteins; S-Nitroso-N-Acetylpenicillamine | 2001 |
Further investigations into the endothelium-dependent hyperpolarizing effects of bradykinin and substance P in porcine coronary artery.
Topics: Animals; Bicarbonates; Biological Factors; Bradykinin; Buffers; Coronary Vessels; Cromakalim; Endothelium, Vascular; Epoprostenol; Glyburide; HEPES; In Vitro Techniques; Indomethacin; Isotonic Solutions; Membrane Potentials; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitroarginine; Peptides; Sodium Chloride; Substance P; Swine; Time Factors; Vasodilator Agents | 2001 |
Chronic estrogen depletion alters adenosine diphosphate-induced pial arteriolar dilation in female rats.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Antifungal Agents; Arterioles; Calcium; Cardiovascular Agents; Endothelium, Vascular; Estrogens; Female; Glyburide; Hypoglycemic Agents; Indomethacin; Miconazole; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Ovariectomy; Peptides; Pia Mater; Potassium Channels; Rats; Rats, Sprague-Dawley; Theophylline; Vasodilation | 2001 |
Characterization of adenosine action in isolated rat renal artery. Possible role of adenosine A(2A) receptors.
Topics: Adenosine; Animals; Caffeine; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Indomethacin; Isotonic Solutions; Male; Models, Animal; Muscle Relaxation; Nitroarginine; Potassium Chloride; Purinergic P1 Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P1; Renal Artery; Tetraethylammonium; Vasodilator Agents; Xanthines | 2000 |
Anandamide-induced relaxation of sheep coronary arteries: the role of the vascular endothelium, arachidonic acid metabolites and potassium channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Animals; Apamin; Arachidonic Acid; Arachidonic Acids; Barium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Fatty Acids, Unsaturated; Glyburide; In Vitro Techniques; Indomethacin; Miconazole; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Potassium; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Receptors, Drug; Rimonabant; Sheep; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation | 2001 |
B16-BL6 melanoma cells release inhibitory factor(s) of active pump activity in isolated lymph vessels.
Topics: Animals; Anti-Arrhythmia Agents; Arginine; Biological Assay; Culture Media, Conditioned; Cyclooxygenase Inhibitors; Decanoic Acids; Endopeptidases; Enzyme Inhibitors; Glyburide; Hot Temperature; Hydroxy Acids; In Vitro Techniques; Indomethacin; Lymph; Lymphatic System; Male; Melanoma, Experimental; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Peptides; Perfusion; Tumor Cells, Cultured | 2001 |
Role of myocardium and endothelium in coronary vascular smooth muscle responses to hypoxia.
Topics: Acetylcholine; Animals; Arachidonic Acid; Coronary Vessels; Endothelium, Vascular; Glyburide; Heart; Hypoxia; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth, Vascular; Nitroarginine; Rats; Rats, Wistar; Temperature; Vasoconstriction | 2002 |
Enhanced endothelin activity prevents vasodilation to insulin in insulin resistance.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelins; Glyburide; In Vitro Techniques; Indomethacin; Insulin; Insulin Resistance; Male; Mesenteric Artery, Superior; Oligopeptides; Potassium Chloride; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Vasodilation | 2002 |
Effects of dental resin components on vascular reactivity.
Topics: Animals; Aorta; Cardiovascular Agents; Composite Resins; Dental Materials; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Methacrylates; Methylmethacrylate; NG-Nitroarginine Methyl Ester; Norepinephrine; Polyethylene Glycols; Polymethacrylic Acids; Rats; Rats, Inbred WKY; Vasoconstrictor Agents; Vasodilator Agents | 2002 |
An endothelium-derived factor modulates purinergic neurotransmission to mesenteric arterial smooth muscle of hamster.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Apamin; Biological Factors; Charybdotoxin; Cricetinae; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Fatty Acids, Unsaturated; Glyburide; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Mesenteric Arteries; Mesocricetus; Muscle, Smooth, Vascular; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ouabain; Pinacidil; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Synaptic Transmission; Tetraethylammonium; Time Factors; Triazines; Uridine Triphosphate; Vasodilator Agents | 2003 |
ATP-sensitive potassium channels mediate dilatation of basilar artery in response to intracellular acidification in vivo.
Topics: Amiloride; Animals; ATP-Binding Cassette Transporters; Basilar Artery; Cells, Cultured; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Glyburide; Hydrogen-Ion Concentration; Indomethacin; Intracellular Fluid; Ion Transport; Macromolecular Substances; Male; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Organ Specificity; Pancreas; Peptides; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Inwardly Rectifying; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sodium-Hydrogen Exchangers; Sulfonylurea Receptors; Vasodilation | 2003 |
Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Electrocardiography; Glyburide; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nociceptin; Oligopeptides; Opioid Peptides; Potassium Channels; Rats; Rats, Wistar | 2003 |
Rho-Rho kinase pathway is involved in the regulation of myogenic tone and pump activity in isolated lymph vessels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Animals; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Intracellular Signaling Peptides and Proteins; Lymphatic System; Male; Muscle Tonus; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Okadaic Acid; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho GTP-Binding Proteins; rho-Associated Kinases; Vasoconstrictor Agents | 2003 |
Endothelium-dependent relaxation to poly-L-arginine in canine coronary arteries.
Topics: Acetylcholine; Animals; Coronary Vessels; Dogs; Endothelium, Vascular; Glyburide; Indomethacin; Muscle Relaxation; Nitric Oxide Synthase; Ouabain; Oxyhemoglobins; Peptides; Vasodilation | 2003 |
Vascular responsiveness to dimethylaminoethyl methacrylate and its degradation products.
Topics: Acetylcholine; Acrylic Resins; Animals; Aorta, Thoracic; Biocompatible Materials; Cyclooxygenase Inhibitors; Deanol; Dental Materials; Endothelium, Vascular; Glyburide; Indomethacin; Isometric Contraction; Male; Methacrylates; NG-Nitroarginine Methyl Ester; Norepinephrine; Prostaglandins; Rats; Rats, Inbred WKY; Resins, Synthetic; Thromboxane A2; Vasoconstriction; Vasodilation | 2003 |
Mechanisms of vasorelaxation to 17beta-oestradiol in rat arteries.
Topics: Animals; Aorta, Thoracic; Calcium; Charybdotoxin; Cyclooxygenase Inhibitors; Endothelium, Vascular; Estradiol; Female; Glyburide; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Potassium Channel Blockers; Rats; Sex Factors; Tamoxifen; Vasodilation | 2003 |
Diclofenac-induced peripheral antinociception is associated with ATP-sensitive K+ channels activation.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hyperalgesia; Indomethacin; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Tolbutamide | 2004 |
Activation of the K+ channel BK(Ca) is involved in the relaxing effect of propofol on coronary arteries.
Topics: Anesthetics, Intravenous; Animals; Calcium Channel Blockers; Coronary Vessels; Cyclooxygenase Inhibitors; Diltiazem; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Indomethacin; Muscle, Smooth, Vascular; Nitroarginine; Potassium Channel Blockers; Potassium Channels; Potassium Chloride; Propofol; Swine; Tetraethylammonium; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
[The effects of sufentanil and remifentanil in the isolated perfused rat kidney].
Topics: Analgesics, Opioid; Animals; Glyburide; Indomethacin; Kidney; Male; Piperidines; Propranolol; Rats; Rats, Wistar; Remifentanil; Sufentanil; Tetraethylammonium | 2004 |
Stimulation of Xenopus P2Y1 receptor activates CFTR in A6 cells.
Topics: Adenosine Diphosphate; Animals; Calcium; Cell Line; Chlorides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Glyburide; Indomethacin; Isoquinolines; Kidney Tubules; Phosphoproteins; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Sodium-Hydrogen Exchangers; Sulfonamides; Thionucleotides; Xenopus laevis | 2004 |
ATP inhibits pump activity of lymph vessels via adenosine A1 receptor-mediated involvement of NO- and ATP-sensitive K+ channels.
Topics: Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Antineoplastic Agents; Arginine; Cardiovascular Agents; Endothelium; Enzyme Inhibitors; Glyburide; Indomethacin; Lymphatic System; Male; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Channels; Rats; Rats, Wistar; Receptor, Adenosine A1; Suramin; Xanthines | 2004 |
Loss of endothelial KATP channel-dependent, NO-mediated dilation of endocardial resistance coronary arteries in pigs with left ventricular hypertrophy.
Topics: Adenosine Triphosphate; Animals; Bradykinin; Brimonidine Tartrate; Canada; Charybdotoxin; Coronary Vessels; Disease Models, Animal; Drug Therapy, Combination; Endocardium; Endothelium, Vascular; Glyburide; Guanylate Cyclase; Hemodynamics; Hypertrophy, Left Ventricular; Indomethacin; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oxadiazoles; Potassium Channels; Quinoxalines; Swine; Vascular Resistance; Vasodilation | 2004 |
Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine.
Topics: Acetylcholine; Administration, Oral; Alcohol Drinking; Animals; Apamin; Atropine; Blood Pressure; Bradykinin; Brazil; Charybdotoxin; Clonidine; Deoxycholic Acid; Drug Therapy, Combination; Endothelium, Vascular; Flavonoids; Glyburide; Guanylate Cyclase; Hypertension; Indomethacin; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroglycerin; Norepinephrine; Oxadiazoles; Perfusion; Phenols; Polyphenols; Potassium Chloride; Pressure; Pyrilamine; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Wine; Yohimbine | 2004 |
Prostaglandin E2--mediated relaxation of the ductus arteriosus: effects of gestational age on g protein-coupled receptor expression, signaling, and vasomotor control.
Topics: 16,16-Dimethylprostaglandin E2; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Adenylyl Cyclases; Alprostadil; Animals; Biphenyl Compounds; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dinoprostone; Ductus Arteriosus; Enzyme Activation; Female; Gestational Age; Glyburide; Indomethacin; Isometric Contraction; NG-Nitroarginine Methyl Ester; Nitroprusside; Papio; Potassium Channels; Pregnancy; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Receptors, Prostaglandin E, EP4 Subtype; Sheep; Signal Transduction; Sodium Fluoride; Thionucleotides; Vasomotor System | 2004 |
Analysis of the mechanism of the vasodepressor effect of urocortin in anesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Administration Schedule; Glyburide; Indomethacin; Infusions, Intravenous; Injections, Intravenous; Male; Methylene Blue; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Norepinephrine; Rats; Rats, Wistar; Tetraethylammonium; Urocortins; Vasodilation | 2005 |
K(+)-induced vasodilation in the rat kidney is dependent on the endothelium and activation of K+ channels.
Topics: Animals; Barium Compounds; Bradykinin; Carbenoxolone; Chlorides; Clotrimazole; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Endothelium; Glyburide; Indomethacin; Kidney; Male; Muscle Contraction; Nitric Oxide; Nitroarginine; Nitroprusside; Phenylephrine; Potassium; Potassium Channels; Prostaglandins; Rats; Rats, Wistar; Tetraethylammonium | 2005 |
Stable 5,6-epoxyeicosatrienoic acid analog relaxes coronary arteries through potassium channel activation.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; Cattle; Coronary Vessels; Drug Stability; Electric Conductivity; Glyburide; In Vitro Techniques; Indomethacin; Patch-Clamp Techniques; Pentanoic Acids; Peptides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Prostaglandin-Endoperoxide Synthases; Vasodilation | 2005 |
Mechanisms involved in the relaxing effect of midazolam on coronary arteries.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Coronary Vessels; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Hypnotics and Sedatives; Hypoglycemic Agents; In Vitro Techniques; Indomethacin; Midazolam; Muscle Relaxation; Muscle, Smooth, Vascular; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroarginine; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Potassium Chloride; Swine; Tetraethylammonium; Vasodilation | 2005 |
Ketamine enantiomers differentially relax isolated coronary artery rings.
Topics: Anesthetics, Dissociative; Animals; Anti-Arrhythmia Agents; Cardiovascular Agents; Coronary Vessels; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Indomethacin; Ketamine; Nitroarginine; Potassium Channel Blockers; Potassium Chloride; Stereoisomerism; Swine; Tetraethylammonium; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
The influence of thermal and mechanical preparative techniques on the amorphous state of four poorly soluble compounds.
Topics: Carbamazepine; Chemistry, Pharmaceutical; Crystallization; Dipyridamole; Drug Stability; Glyburide; Indomethacin; Powder Diffraction; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; Temperature; Thermogravimetry; X-Ray Diffraction | 2005 |
Calcitonin gene-related peptide activates different signaling pathways in mesenteric lymphatics of guinea pigs.
Topics: Animals; Calcitonin Gene-Related Peptide; Cyclic AMP; Cyclooxygenase Inhibitors; Electrophysiology; Endothelium; Female; Glyburide; Guinea Pigs; Indomethacin; Lymphatic Vessels; Male; Mesentery; Muscle, Smooth; Nitric Oxide; Peptide Fragments; Pertussis Toxin; Signal Transduction | 2006 |
Endothelium-dependent induction of vasorelaxation by the butanol extract of Phellinus igniarius in isolated rat aorta.
Topics: Animals; Aorta; Atropine; Butanols; Cyclic GMP; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Oxadiazoles; Polyporaceae; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation; Vasodilator Agents; Verapamil | 2006 |
LPS from Escherichia coli protects against indomethacin-induced gastropathy in rats--role of ATP-sensitive potassium channels.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Diazoxide; Escherichia coli; Glyburide; Hypoglycemic Agents; Indomethacin; Injections, Intravenous; Leukocyte Count; Lipopolysaccharides; Male; Peroxidase; Potassium Channels, Inwardly Rectifying; Protective Agents; Rats; Rats, Wistar; Stomach Diseases | 2006 |
Amifostine (Wr-2721) prevents indomethacin-induced gastric damage in rats: role of non-protein sulfhydryl groups and leukocyte adherence.
Topics: Adhesiveness; Amifostine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Glyburide; Immunohistochemistry; Indomethacin; Leukocytes; Male; NG-Nitroarginine Methyl Ester; Radiation-Protective Agents; Rats; Rats, Wistar; Stomach Diseases; Sulfhydryl Compounds | 2007 |
Testosterone relaxes isolated human radial artery by potassium channel opening action.
Topics: 4-Aminopyridine; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glyburide; Humans; In Vitro Techniques; Indomethacin; NG-Nitroarginine Methyl Ester; Perfusion; Phenylephrine; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Potassium Chloride; Radial Artery; Testosterone; Tetraethylammonium; Vasoconstrictor Agents; Vasodilation | 2007 |
Vasorelaxant effects of icariin on isolated canine coronary artery.
Topics: Analysis of Variance; Animals; Anti-Arrhythmia Agents; Coronary Vessels; Dinoprost; Dogs; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Endothelium, Vascular; Enzyme Inhibitors; Female; Flavonoids; Glyburide; Indomethacin; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxadiazoles; Oxytocics; Potassium Channel Blockers; Quinoxalines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetraethylammonium; Vasodilation | 2007 |
Vasodilator effect of nicorandil on retinal blood vessels in rats.
Topics: Analysis of Variance; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Glyburide; Indomethacin; Male; Nicorandil; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pinacidil; Potassium Channel Blockers; Rats; Rats, Wistar; Retinal Vessels; Vasodilation; Vasodilator Agents | 2007 |
Investigation of relaxant effects of propofol on sheep sphincter of Oddi.
Topics: 4-Aminopyridine; Anesthetics, Intravenous; Animals; Dose-Response Relationship, Drug; Drug Combinations; Glyburide; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Propofol; Sheep; Sphincter of Oddi; Tetraethylammonium | 2007 |
COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Topics: Adenosine Triphosphate; Animals; Calcium Signaling; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Depression, Chemical; Diastole; Diclofenac; Disease Models, Animal; Glyburide; In Vitro Techniques; Indomethacin; Myocardial Contraction; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Nitrobenzenes; Perfusion; Potassium Channel Blockers; Potassium Channels; Rats; Reperfusion Injury; Research Design; Sulfonamides; Systole; Time Factors | 2007 |
C-type natriuretic peptide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery.
Topics: Acetylcholine; Animals; Bee Venoms; Biological Factors; Carotid Arteries; Endothelium, Vascular; Glyburide; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Membrane Potentials; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Nitroarginine; Vasodilation | 2008 |
Quebrachitol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide and K+ ATP channels.
Topics: Animals; Arginine; Capsaicin; Diazoxide; Dose-Response Relationship, Drug; Ethanol; Glyburide; Indomethacin; Inositol; KATP Channels; Male; Mice; Misoprostol; Molecular Structure; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phytotherapy; Prostaglandins; Stomach Ulcer | 2008 |
Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats.
Topics: Animals; Eugenol; Gastric Mucosa; Glyburide; Indomethacin; Male; Malondialdehyde; Nitrites; Rats; Rats, Sprague-Dawley; Ruthenium Red; Stomach; Stomach Ulcer | 2008 |
Gastroprotective mechanisms of centipedic acid, a natural diterpene from Egletes viscosa LESS.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Asteraceae; Capsaicin; Central Nervous System Depressants; Diterpenes; Drug Interactions; Enzyme Inhibitors; Ethanol; Fatty Acids, Unsaturated; Free Radical Scavengers; Furans; Gastric Mucosa; Glyburide; Hypoglycemic Agents; Indomethacin; Male; Mice; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Oxidative Stress; Pylorus; Stomach Ulcer; Sulfhydryl Compounds; Thiobarbituric Acid Reactive Substances | 2008 |
Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed.
Topics: 4-Aminopyridine; Acetylcholine; Administration, Oral; Animals; Aorta; Blood Glucose; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Fructose; Glyburide; In Vitro Techniques; Indomethacin; Insulin; Insulin Resistance; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Peptides; Phenylephrine; Potassium Channel Blockers; Potassium Chloride; Rats; Rats, Sprague-Dawley; Taurine; Tetraethylammonium; Vasoconstriction; Vasodilation | 2008 |
Vasorelaxant effect of a self-etch adhesive system through calcium antagonistic action.
Topics: 4-Aminopyridine; Animals; Aorta, Thoracic; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Dentin-Bonding Agents; Endothelium, Vascular; Enzyme Inhibitors; Epoprostenol; Glyburide; Indomethacin; Male; Materials Testing; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Time Factors; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Investigating the potential role of multi-drug resistance protein (MRP) transporters in fetal to maternal glyburide efflux in the human placenta.
Topics: Adult; Diabetes, Gestational; Female; Glyburide; Humans; Hypoglycemic Agents; Indomethacin; Male; Maternal-Fetal Exchange; Multidrug Resistance-Associated Proteins; Placenta; Pregnancy | 2008 |
Gastroprotective mechanism of Vanillosmopsis arborea bark essential oil.
Topics: Adrenergic alpha-Antagonists; Animals; Anti-Ulcer Agents; Asteraceae; Enzyme Inhibitors; Ethanol; Gastric Mucosa; Glyburide; Indomethacin; Male; Mice; Models, Animal; Monocyclic Sesquiterpenes; NG-Nitroarginine Methyl Ester; Oils, Volatile; Phytotherapy; Plant Bark; Plant Extracts; Sesquiterpenes; Stomach Ulcer; Yohimbine | 2009 |
The relaxation mechanisms of tetrandrine on the rabbit corpus cavernosum tissue in vitro.
Topics: 4-Aminopyridine; Animals; Benzylisoquinolines; Drugs, Chinese Herbal; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; Nitroarginine; Oxadiazoles; Penis; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Rabbits; Stephania tetrandra; Tetraethylammonium | 2009 |
Effect of acidosis on the mechanism(s) of insulin-induced vasorelaxation in normal Wistar-Kyoto (WKY) rat aorta.
Topics: 4-Aminopyridine; Acidosis; Animals; Aorta; Barium Compounds; Chlorides; Endothelium, Vascular; Glyburide; Hydrogen-Ion Concentration; Hypoglycemic Agents; Indomethacin; Insulin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Ouabain; Phenylephrine; Potassium Channel Blockers; Rats; Rats, Inbred WKY; Tetraethylammonium; Vasoconstriction; Vasodilation | 2009 |
A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1,3,4-oxadiazole derivative, an L-type Ca2+ channel blocker in deoxycorticosterone acetate and N(G)-nitro-l-arginine hypertensive r
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Calcium Channel Blockers; Calcium Channels, L-Type; Desoxycorticosterone; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Hypertension; Indomethacin; Male; Nitroarginine; Norepinephrine; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2010 |
Gastroprotective effect of barbatusin and 3-beta-hydroxy-3-deoxibarbatusin, quinonoid diterpenes isolated from Plectranthus grandis, in ethanol-induced gastric lesions in mice.
Topics: Acetylcysteine; Animals; Anti-Ulcer Agents; Antioxidants; Capsaicin; Disease Models, Animal; Diterpenes; Ethanol; Gastric Mucosa; Glyburide; Indomethacin; Male; Mice; Mucus; NG-Nitroarginine Methyl Ester; Phytotherapy; Plant Extracts; Plant Leaves; Plectranthus; Quinones; Stomach; Stomach Ulcer; Sulfhydryl Compounds; Thiobarbiturates | 2010 |
In vitro vascular effects produced by crude aqueous extract of green marine algae, Cladophora patentiramea (Mont.) Kützing, in aorta from normotensive rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Aorta; Atropine; Chlorophyta; Endothelium, Vascular; Glyburide; In Vitro Techniques; Indomethacin; Malaysia; Male; Nitric Oxide; Phenylephrine; Phytotherapy; Rats; Rats, Inbred WKY; Vasoconstrictor Agents; Vasodilation | 2010 |
Stimulation of duodenal HCO₃⁻ secretion by hydrogen sulphide in rats: relation to prostaglandins, nitric oxide and sensory neurones.
Topics: Air Pollutants; Alkynes; Animals; Bicarbonates; Capsaicin; Dinoprostone; Duodenum; Enzyme Inhibitors; Glyburide; Glycine; Hydrogen Sulfide; Hypoglycemic Agents; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Sensory System Agents; Sulfides | 2011 |
Exploring the mechanism of endothelial involvement in acidosis-induced vasodilatation of aortic tissues from normal and diabetic rats.
Topics: 4-Aminopyridine; Acidosis; Animals; Aorta; Barium Compounds; Chlorides; Diabetes Mellitus; Endothelium, Vascular; Glucose Clamp Technique; Glyburide; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Peptides; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation | 2010 |
Diazoxide attenuates indomethacin-induced small intestinal damage in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Diazoxide; Glyburide; Indomethacin; Intestine, Small; Ion Channel Gating; KATP Channels; Lipid Peroxidation; Male; Peroxidase; Potassium Channel Blockers; Rats; Rats, Wistar | 2011 |
Gastroprotective potential of risperidone, an atypical antipsychotic, against stress and pyloric ligation induced gastric lesions.
Topics: Animals; Antipsychotic Agents; Capillary Permeability; Dinoprostone; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Glyburide; Hexosamines; Indomethacin; KATP Channels; Ketanserin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Receptors, Dopamine D2; Receptors, Serotonin, 5-HT2; Risperidone; Stomach Ulcer; Stress, Physiological; Sulfhydryl Compounds; Sulpiride | 2011 |
Vasodilatory effect of hydroxyethyl methacrylate and triethylene glycol dimethacrylate in rat aorta through calcium antagonistic action.
Topics: 4-Aminopyridine; Animals; Aorta, Thoracic; Calcium; Calcium Channel Blockers; Calcium Chloride; Composite Resins; Cyclooxygenase Inhibitors; Dental Materials; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; Indomethacin; Male; Methacrylates; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase; Polyethylene Glycols; Polymethacrylic Acids; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Transducers; Vasoconstrictor Agents; Vasodilator Agents | 2011 |
Rat intestinal precision-cut slices as an in vitro model to study xenobiotic interaction with transporters.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Fluoresceins; Fluorescent Dyes; Glyburide; Indomethacin; Intestine, Small; Male; Microtomy; Multidrug Resistance-Associated Proteins; Rats; Rats, Wistar; Verapamil; Xenobiotics | 2011 |
Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs.
Topics: Biological Availability; Calorimetry, Differential Scanning; Gastric Mucosa; Glyburide; Hydrogen-Ion Concentration; Indomethacin; Pharmaceutical Preparations; Silicon Dioxide; Solubility | 2011 |
Gastroprotective potential of frutalin, a D-galactose binding lectin, against ethanol-induced gastric lesions.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Biomarkers; Capsaicin; Cimetidine; Ethanol; Galactose; Galectins; Gastric Mucosa; Glutathione; Glyburide; Indomethacin; Male; Malondialdehyde; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Oxidative Stress; Phytotherapy; Plant Extracts; Stomach Ulcer | 2012 |
Endothelium-derived relaxing factor-mediated vasodilation in mouse mesenteric vascular beds.
Topics: Acetylcholine; Animals; Biological Factors; Calcimycin; Calcium Ionophores; Cyclooxygenase Inhibitors; Endothelium-Dependent Relaxing Factors; Endothelium, Vascular; Enzyme Inhibitors; Gap Junctions; Glyburide; Glycyrrhetinic Acid; Indomethacin; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Potassium Channel Blockers; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2012 |
Hydrogen sulfide mediated inhibitory neurotransmission to the pig bladder neck: role of KATP channels, sensory nerves and calcium signaling.
Topics: Acetanilides; Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcitonin Gene-Related Peptide; Calcium Signaling; Capsaicin; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Glyburide; Guanylate Cyclase; Hydrogen Sulfide; Indomethacin; KATP Channels; Morpholines; Muscle, Smooth; Organothiophosphorus Compounds; Phenylephrine; Pituitary Adenylate Cyclase-Activating Polypeptide; Purines; Pyrazoles; Sensory Receptor Cells; Swine; Synaptic Transmission; Urinary Bladder | 2013 |
Mechanisms of vasorelaxation to gamma-mangostin in the rat aorta.
Topics: Analysis of Variance; Animals; Aorta; Barium Compounds; Calcium Chloride; Chlorides; Endothelium, Vascular; Glyburide; Indomethacin; Male; Methoxamine; NG-Nitroarginine Methyl Ester; Oxadiazoles; Quinoxalines; Rats; Rats, Wistar; Tetraethylammonium; Vasodilation; Vasodilator Agents; Xanthones | 2012 |
Are anti-inflammatory properties of lipoic acid associated with the formation of hydrogen sulfide?
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship, Drug; Edema; Glyburide; Hindlimb; Hydrogen Sulfide; Indomethacin; Male; Mice; Potassium Channel Blockers; Thioctic Acid | 2013 |
The role of endothelium-derived hyperpolarizing factor and cyclooxygenase pathways in the inhibitory serotonergic response to the pressor effect elicited by sympathetic stimulation in chronic sarpogrelate treated rats.
Topics: Animals; Biological Factors; Electric Stimulation; Glyburide; Hemodynamics; Indomethacin; Male; Nitric Oxide; Oxadiazoles; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Succinates; Sympathetic Nervous System; Synaptic Transmission | 2014 |
Onset of diabetes modulates the airway smooth muscle reactivity of guinea pigs: role of epithelial mediators.
Topics: Acetylcholine; Animals; Bronchi; Bronchoconstriction; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Female; Glyburide; Guinea Pigs; In Vitro Techniques; Indomethacin; Isoproterenol; KATP Channels; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandin-Endoperoxide Synthases; Respiratory Mucosa; Signal Transduction; Streptozocin | 2014 |
Helicteres sacarolha A. St.- Hil. et al.: gastroprotective and possible mechanism of actions in experimental animals.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Catalase; Ethanol; Gastric Juice; Gastric Mucosa; Glyburide; Indomethacin; Malvaceae; Mice; NG-Nitroarginine Methyl Ester; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Stomach Ulcer; Yohimbine | 2015 |
Predicting the Solubility Advantage of Amorphous Pharmaceuticals: A Novel Thermodynamic Approach.
Topics: Crystallization; Glyburide; Griseofulvin; Hydrochlorothiazide; Indomethacin; Itraconazole; Models, Theoretical; Solubility; Solvents; Thermodynamics; Water | 2015 |
Effect of Heparin on Contractile Activity of Lymph Node Capsule.
Topics: Animals; Cattle; Electric Stimulation; Endothelial Cells; Glyburide; Heparin; Hormesis; Indomethacin; Isometric Contraction; KATP Channels; Lymph Nodes; Mesentery; Methylene Blue; Muscle, Smooth; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide; Tissue Culture Techniques | 2015 |
Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Ethylmaleimide; Glyburide; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Pyrazoles; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2016 |
Pharmacological study of the mechanisms involved in the vasodilator effect produced by the acute application of triiodothyronine to rat aortic rings.
Topics: Animals; Aorta, Thoracic; Atropine; Dimethyl Sulfoxide; Endothelium, Vascular; Glyburide; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Phenylephrine; Potassium Channels, Calcium-Activated; Rats, Wistar; Triiodothyronine; Vasodilation; Vasodilator Agents | 2016 |
Gastroprotective and ulcer healing effects of hydroethanolic extract of leaves of Caryocar coriaceum: Mechanisms involved in the gastroprotective activity.
Topics: Animals; Antioxidants; Capsaicin; Chromatography, High Pressure Liquid; Chronic Disease; Disease Models, Animal; Ericales; Ethanol; Female; Flavonoids; Gastrointestinal Motility; Glyburide; Histamine; Indomethacin; Male; Mice; Mucus; Naloxone; NG-Nitroarginine Methyl Ester; Phenols; Phytotherapy; Plant Extracts; Plant Leaves; Protective Agents; Stomach Ulcer; Water; Yohimbine | 2017 |
Deterioration of epithelium mediated mechanisms in diabetic-antigen sensitized airways of guinea pigs.
Topics: Acetylcholine; Animals; Antigens, Bacterial; Bacterial Proteins; Bronchial Hyperreactivity; Bronchoconstriction; Diabetes Complications; Diabetes Mellitus, Experimental; Female; Glyburide; Guinea Pigs; Humans; Indomethacin; Isoproterenol; Male; Muscle, Smooth; Nitric Oxide; Prostaglandin-Endoperoxide Synthases; Respiratory Mucosa; Streptozocin; Trachea | 2016 |
Electron microscopy/energy dispersive X-ray spectroscopy of drug distribution in solid dispersions and interpretation by multifractal geometry.
Topics: Amlodipine; Crystallography, X-Ray; Dosage Forms; Drug Carriers; Drug Compounding; Felodipine; Fractals; Glyburide; Indomethacin; Methylcellulose; Microscopy, Electron, Scanning; Pharmaceutical Preparations; Powder Diffraction; Solubility; Spectrometry, X-Ray Emission; Technology, Pharmaceutical | 2018 |
Kaempferol-induces vasorelaxation via endothelium-independent pathways in rat isolated pulmonary artery.
Topics: Animals; Apamin; Barium Compounds; Calcium Chloride; Chlorides; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Fulvestrant; Glyburide; In Vitro Techniques; Indomethacin; Isoquinolines; Kaempferols; Male; Morpholines; NG-Nitroarginine Methyl Ester; Oxadiazoles; Peptides; Potassium; Pulmonary Artery; Pyrroles; Quinoxalines; Rats; Sulfonamides; Tetraethylammonium; Vasodilation; Vasodilator Agents | 2018 |
Gastroprotective effect of memantine in indomethacin-induced peptic ulcer in rats, a possible role for potassium channels.
Topics: Animals; Anti-Ulcer Agents; Glyburide; Indomethacin; Male; Memantine; Nitric Oxide Synthase; Oxidative Stress; Peptic Ulcer; Potassium Channels; Rats; Rats, Wistar | 2019 |
Modeling Recrystallization Kinetics Following the Dissolution of Amorphous Drugs.
Topics: Chemistry, Pharmaceutical; Crystallization; Glyburide; Indomethacin; Kinetics; Loratadine; Models, Chemical; Pharmaceutical Preparations; Solubility; Terfenadine | 2020 |
Electrical field stimulation induces endothelium-dependent contraction of human umbilical cord vessels.
Topics: Adult; Atropine; Blood Vessels; Electric Stimulation; Glyburide; Humans; Indomethacin; Muscle Contraction; Tetrodotoxin; Umbilical Cord; Young Adult | 2020 |
Elabela relaxes rat pulmonary artery and trachea via BK
Topics: 4-Aminopyridine; Adenosine Triphosphate; Animals; Dideoxyadenosine; Endothelium, Vascular; Glyburide; Indomethacin; Male; Prostaglandins; Pulmonary Artery; Rats; Rats, Wistar; Trachea; Vascular Ring; Vasodilation; Vasodilator Agents | 2023 |