indomethacin and chlorpropamide

indomethacin has been researched along with chlorpropamide in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (29.03)	18.7374
1990's	1 (3.23)	18.2507
2000's	6 (19.35)	29.6817
2010's	15 (48.39)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Corleto, LA; Knaus, EE; Yeung, JM	1
Topliss, JG; Yoshida, F	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Anacardio, R; Aureli, L; Cesta, MC; Cruciani, G; De Simone, L; Moriconi, A	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Buttar, D; Colclough, N; Gerhardt, S; MacFaul, PA; Maskos, K; Phillips, SD; Plowright, A; Steinbacher, S; Steuber, H; Tam, K; Whittamore, P	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL	1
Jaeger, W	1
Green, IC; Tadayyon, M	1
da Cruz, I; Meiring, Pde V	1
Barnett, AH; Pyke, DA; Spiliopoulos, AJ	1
Zusman, RM	1
Bowcock, S; Cooke, ED; Johnston, C; Medbak, S; Pyke, DA; Rees, LH; Wiles, PG	1
Carey, F; Forder, RA; Haworth, D; Johnston, C	1
Barnett, AH; Koullapis, EN; Nicolaides, K; Pyke, DA; Spiliopoulos, AJ	1
Robinson, AG; Verbalis, JG	1

Reviews

2 review(s) available for indomethacin and chlorpropamide

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Prostaglandins, vasopressin, and renal water reabsorption. The Medical clinics of North America, 1981, Volume: 65, Issue:4 Topics: Adrenocorticotropic Hormone; Animals; Chlorpropamide; Dinoprostone; Humans; Indomethacin; Kidney; Prostaglandins; Prostaglandins E; Vasopressins; Water	1981

Trials

1 trial(s) available for indomethacin and chlorpropamide

Article	Year
Prostacyclin and thromboxane in non-insulin dependent diabetes: the chlorpropamide alcohol flush reaction revisited. Clinical science (London, England : 1979), 1984, Volume: 67, Issue:6 Topics: 6-Ketoprostaglandin F1 alpha; Adult; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Female; Flushing; Forearm; Humans; Indomethacin; Ischemia; Male; Middle Aged; Radioimmunoassay; Thromboxane B2; Thromboxanes	1984

Article

Year

Prostacyclin and thromboxane in non-insulin dependent diabetes: the chlorpropamide alcohol flush reaction revisited.

Clinical science (London, England : 1979), 1984, Volume: 67, Issue:6

Topics: 6-Ketoprostaglandin F1 alpha; Adult; Chlorpropamide; Diabetes Mellitus, Type 2; Ethanol; Female; Flushing; Forearm; Humans; Indomethacin; Ischemia; Male; Middle Aged; Radioimmunoassay; Thromboxane B2; Thromboxanes

1984

Other Studies

28 other study(ies) available for indomethacin and chlorpropamide

Article	Year
Synthesis of N-[[(substituted-phenyl)carbonyl]amino]-1,2,3,6-tetrahydropyridines with analgesic and hyperglycemic activity. Journal of medicinal chemistry, 1982, Volume: 25, Issue:6 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Blood Glucose; Chemical Phenomena; Chemistry; Female; Hypoglycemic Agents; Male; Mice; Pyridines; Rats; Rats, Inbred Strains; Solubility	1982
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Predicting human serum albumin affinity of interleukin-8 (CXCL8) inhibitors by 3D-QSPR approach. Journal of medicinal chemistry, 2005, Apr-07, Volume: 48, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Chemical Phenomena; Chemistry, Physical; Humans; In Vitro Techniques; Interleukin-8; Models, Molecular; Phenylpropionates; Protein Binding; Quantitative Structure-Activity Relationship; Serum Albumin; Stereoisomerism	2005
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions. Bioorganic & medicinal chemistry, 2010, Nov-01, Volume: 18, Issue:21 Topics: Binding Sites; Crystallography, X-Ray; Drug Interactions; Humans; Pharmaceutical Preparations; Protein Binding; Protein Structure, Tertiary; Serum Albumin; Spectrometry, Fluorescence	2010
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics. PloS one, 2016, Volume: 11, Issue:10 Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat	2016
[Acquired colour-vision-deficiencies caused by side-effects of pharmacotherapy (author's transl)]. Klinische Monatsblatter fur Augenheilkunde, 1977, Volume: 170, Issue:3 Topics: Antipsychotic Agents; Chloramphenicol; Chloroquine; Chlorpropamide; Color Vision Defects; Contraceptives, Oral; Digitoxin; Ethambutol; Humans; Indomethacin; Monoamine Oxidase Inhibitors; Optic Neuritis; Phenothiazines; Retinal Diseases; Sparsomycin	1977
Opiate-prostaglandin interactions in the regulation of insulin secretion from rat islets of Langerhans in vitro. Life sciences, 1988, Volume: 42, Issue:21 Topics: Animals; Chlorpropamide; Dinoprostone; Dynorphins; Female; In Vitro Techniques; Indomethacin; Insulin; Insulin Secretion; Islets of Langerhans; Prostaglandins E; Radioimmunoassay; Rats; Rats, Inbred Strains; Sodium Salicylate	1988
To the Editor. Adverse effects from drugs. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1969, Sep-27, Volume: 43, Issue:39 Topics: Chlorpropamide; Digoxin; Drug-Related Side Effects and Adverse Reactions; Indomethacin; Penicillins; Prednisone; Streptomycin; Tetracycline; Thiopental; Warfarin	1969
Blockade of chlorpropamide-alcohol flushing by indomethacin suggests an association between prostaglandins and diabetic vascular complications. Lancet (London, England), 1980, Jul-26, Volume: 2, Issue:8187 Topics: Blood Vessels; Chlorpropamide; Diabetes Mellitus; Diabetic Angiopathies; Ethanol; Face; Female; Humans; Indomethacin; Middle Aged; Pregnancy; Prostaglandins; Skin Temperature; Twins	1980
The role of endogenous opioids in the chlorpropamide alcohol flush. Clinical endocrinology, 1984, Volume: 21, Issue:5 Topics: Administration, Oral; Adult; Aged; Chlorpropamide; Diabetes Mellitus, Type 2; Drug Interactions; Enkephalin, Methionine; Ethanol; Female; Flushing; Humans; Indomethacin; Injections, Intravenous; Male; Middle Aged; Naloxone	1984
Circulating prostanoid levels, both basal and during the chlorpropamide alcohol flush, in non-insulin dependent diabetes. Clinical endocrinology, 1981, Volume: 15, Issue:5 Topics: 6-Ketoprostaglandin F1 alpha; Alcoholic Beverages; Chlorpropamide; Diabetes Mellitus; Face; Female; Humans; Hyperemia; Indomethacin; Male; Middle Aged; Prostaglandins; Prostaglandins F; Thromboxane B2	1981
Diabetes insipidus. Current therapy in endocrinology and metabolism, 1994, Volume: 5 Topics: Benzothiadiazines; Carbamazepine; Chlorpropamide; Clofibrate; Diabetes Insipidus; Diuretics; Female; Humans; Indomethacin; Life Style; Pregnancy; Pregnancy Complications; Sodium Chloride Symporter Inhibitors; Thirst; Vasopressins; Water	1994