indomethacin and chlorambucil

indomethacin has been researched along with chlorambucil in 36 studies

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-199018 (50.00)18.7374
1990's1 (2.78)18.2507
2000's8 (22.22)29.6817
2010's8 (22.22)24.3611
2020's1 (2.78)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Doman, TN; McGovern, SL; Seidler, J; Shoichet, BK1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Lombardo, F; Obach, RS; Waters, NJ1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Barton, P; Luker, T; Wenlock, MC1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Brodsky, JL; Chiang, A; Chung, WJ; Denny, RA; Goeckeler-Fried, JL; Havasi, V; Hong, JS; Keeton, AB; Mazur, M; Piazza, GA; Plyler, ZE; Rasmussen, L; Rowe, SM; Sorscher, EJ; Weissman, AM; White, EL1
Daniel Pedro-Hernández, L; Hernández-Montalbán, C; Martínez-García, M; Martínez-Klimova, E; Ramírez-Ápan, T1
Rosenberg, MJ; Simon, NM1
Blanc, AP; Carcassonne, Y; Gastaut, JA1
Millar, JL; Powles, TJ1
Di Toro, R1
Ratner, MIa; Samokhina, NM; Tomilina, NA1
Klaus, D1
Katargina, LA; Rozvadovskaia, OS; Sarsembaeva, RT; Shakhbazian, IE; Sushkova, NI; Ulybina, OV1
Cattan, AR; Hall, A; Harris, AL; Hickson, ID; Proctor, SJ; Robson, CN1
Steiger, U1
Blanc-Brunat, N; Colon, S; Dupont, E; Fries, D; Labeeuw, M; Pozet, N; Richard, P; Traeger, J; Zech, P1
Clarkson, AR; Robson, JS1
Gradowska, L; Lao, M; Orlowski, T; Rancewicz, Z; Rowinska, D1
Geneste, F; Manassero, J; Paglia, R; Vaillaud, JC1
Brass, H1
Forbes, IJ; Smith, JL1
Banfi, G; Imbasciati, E; Ponticelli, C; Tarantino, A1
Dobrzanski, RJ; Gibbs, J; Tisdale, MJ1
Broyer, M; Gubler, MC; Kleinknecht, C; Palcoux, JB1
Frank, GJ; Millar, JL; Powles, TJ1
Bacchelli, B; Boraldi, F; Croce, MA; Garcia Fernandez, MI; Gheduzzi, D; Pasquali Ronchetti, I; Quaglino, D; Tiozzo, R1
Cao, Y; Guo, M; Liu, K; Liu, X; Yan, H; Yan, Y; Zhang, H1

Reviews

4 review(s) available for indomethacin and chlorambucil

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Medical treatment of glomerular diseases.
    The Medical clinics of North America, 1978, Volume: 62, Issue:6

    Topics: Adult; Anti-Glomerular Basement Membrane Disease; Azathioprine; Child; Chlorambucil; Cyclophosphamide; Dipyridamole; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Humans; Immune Complex Diseases; Immunoglobulin A; Indomethacin; Kidney Glomerulus; Prednisone; Warfarin

1978
The effect of drugs on immunological renal disease.
    Progress in biochemical pharmacology, 1972, Volume: 7

    Topics: Adrenal Cortex Hormones; Antilymphocyte Serum; Azathioprine; Chlorambucil; Cyclophosphamide; Glomerulonephritis; Hemolytic-Uremic Syndrome; Heparin; Humans; Immunity; Immunosuppression Therapy; Indomethacin; Lupus Erythematosus, Systemic; Malaria

1972
Immunosuppressive therapy in primary glomerulonephritis (pros).
    Contributions to nephrology, 1982, Issue:34

    Topics: Adrenocorticotropic Hormone; Azathioprine; Chlorambucil; Cyclophosphamide; Dipyridamole; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Heparin; Humans; Immunosuppressive Agents; Indomethacin; Methylprednisolone; Nephrosis, Lipoid; Prednisone; Steroids

1982

Trials

2 trial(s) available for indomethacin and chlorambucil

ArticleYear
[Use of chlorbutin in the complex treatment of systemic forms of juvenile rheumatoid arthritis].
    Pediatriia, 1990, Issue:3

    Topics: Adolescent; Anti-Inflammatory Agents; Arthritis, Juvenile; Child; Child, Preschool; Chlorambucil; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Indomethacin; Male; Myocarditis; Pericarditis; Rheumatic Heart Disease; Steroids

1990
Irreversible renal failure after indomethacin in steroid-resistant nephrosis.
    The New England journal of medicine, 1980, Mar-20, Volume: 302, Issue:12

    Topics: Child; Chlorambucil; Clinical Trials as Topic; Female; Glomerular Filtration Rate; Humans; Indomethacin; Kidney Failure, Chronic; Male; Nephrosis; Nephrotic Syndrome; Remission, Spontaneous

1980

Other Studies

30 other study(ies) available for indomethacin and chlorambucil

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Identification and prediction of promiscuous aggregating inhibitors among known drugs.
    Journal of medicinal chemistry, 2003, Oct-09, Volume: 46, Issue:21

    Topics: Antifungal Agents; beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry, Physical; Chymotrypsin; Enzyme Inhibitors; Kinetics; Light; Malate Dehydrogenase; Models, Molecular; Molecular Conformation; Scattering, Radiation; Structure-Activity Relationship

2003
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Lipophilicity of acidic compounds: impact of ion pair partitioning on drug design.
    Bioorganic & medicinal chemistry letters, 2011, Jun-15, Volume: 21, Issue:12

    Topics: Acids; Albumins; Drug Design; Humans; Hydrogen-Ion Concentration; Lipids; Molecular Structure; Pharmaceutical Preparations; Protein Binding

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Alleles; Benzoates; Cells, Cultured; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Furans; Gene Deletion; HEK293 Cells; HeLa Cells; High-Throughput Screening Assays; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Protein Folding; Protein Structure, Tertiary; Pyrazoles; RNA, Messenger; Small Molecule Libraries; Ubiquitination; Vorinostat

2016
Synthesis and anticancer activity of open-resorcinarene conjugates.
    Bioorganic & medicinal chemistry letters, 2020, 07-15, Volume: 30, Issue:14

    Topics: Animals; Antineoplastic Agents; Calixarenes; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; COS Cells; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Phenylalanine; Structure-Activity Relationship

2020
Acute leukemia after prolonged immunosuppressive therapy for glomerulonephritis.
    Cancer treatment reports, 1978, Volume: 62, Issue:7

    Topics: Adolescent; Alkylating Agents; Chlorambucil; Dipyridamole; Glomerulonephritis; Humans; Indomethacin; Leukemia, Myeloid, Acute; Male; Middle Aged

1978
Non-steroidal anti-inflammatory drugs and cytotoxics.
    Cancer treatment reviews, 1979, Volume: 6 Suppl

    Topics: Animals; Bone Marrow; Carcinoma 256, Walker; Chlorambucil; Digestive System; Flurbiprofen; Indomethacin; Melphalan; Mice; Propionates; Rats

1979
[Therapy of lipoid nephrosis].
    La Pediatria, 1977, Dec-31, Volume: 85, Issue:4

    Topics: Calcium; Child; Child, Preschool; Chlorambucil; Diuretics; Glucocorticoids; Humans; Immunosuppressive Agents; Indomethacin; Infant; Nephrosis, Lipoid; Vitamin D

1977
[Criteria for the outcome of treatment of chronic glomerulonephritis and the evaluation of the effectiveness of current therapeutic methods].
    Terapevticheskii arkhiv, 1978, Volume: 50, Issue:1

    Topics: Adult; Aged; Chlorambucil; Chronic Disease; Drug Evaluation; Female; Glomerulonephritis; Heparin; Humans; Indomethacin; Male; Middle Aged; Prednisolone

1978
[Conservative therapy of chronic glomerulonephritis].
    Deutsche medizinische Wochenschrift (1946), 1978, May-12, Volume: 103, Issue:19

    Topics: Acidosis; Azathioprine; Chlorambucil; Chronic Disease; Chronic Kidney Disease-Mineral and Bone Disorder; Cyclophosphamide; Glomerulonephritis; Humans; Hyperkalemia; Hypertension, Renal; Indomethacin; Prednisolone

1978
Possible role of inhibition of glutathione S-transferase in the partial reversal of chlorambucil resistance by indomethacin in a Chinese hamster ovary cell line.
    Cancer research, 1989, Nov-15, Volume: 49, Issue:22

    Topics: Animals; Aspirin; Cell Line; Cell Survival; Chlorambucil; Cricetinae; Cricetulus; Drug Resistance; Female; Glutathione Transferase; Immunoblotting; Indomethacin; Kinetics; Ovary

1989
[Therapy of chronic polyarthritis in the practice].
    Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1971, May-18, Volume: 60, Issue:20

    Topics: Adrenocorticotropic Hormone; Arthritis, Rheumatoid; Azathioprine; Chlorambucil; Chronic Disease; Cyclophosphamide; Gold; Humans; Indomethacin; Massage; Phenylbutazone; Physical Therapy Modalities

1971
[Course of nephropathy in systemic lupus erythematosus . Influence of the treatment on clinical symptoms, renal function and histology].
    Journal d'urologie et de nephrologie, 1972, Volume: 78, Issue:12

    Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Antimalarials; Azathioprine; Biopsy; Chlorambucil; Female; Glomerulonephritis; Humans; Indomethacin; Kidney Function Tests; Lupus Erythematosus, Systemic; Male; Middle Aged; Nephrotic Syndrome; Prednisone; Prognosis; Proteinuria

1972
[Treatment of chronic glomerulopathy].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1972, Nov-15, Volume: 27, Issue:22

    Topics: Anti-Inflammatory Agents; Azathioprine; Biopsy; Chlorambucil; Chronic Disease; Creatine; Cyclophosphamide; Glomerulonephritis; Humans; Immunosuppressive Agents; Indomethacin; Mercaptopurine; Prednisone; Proteinuria

1972
[A case of acute glomerulonephritis supposed to be malignant. Complete clinical, biological and histological remission after a combined chlorambucil and indomethacin treatment].
    Pediatrie, 1970, Volume: 25, Issue:2

    Topics: Acute Disease; Child; Chlorambucil; Diagnosis, Differential; Female; Glomerulonephritis; Humans; Indomethacin

1970
[Therapeutic possibilities in chronic glomerulonephritis].
    Munchener medizinische Wochenschrift (1950), 1969, Aug-29, Volume: 111, Issue:35

    Topics: Adolescent; Adult; Azathioprine; Chlorambucil; Chronic Disease; Glomerulonephritis; Humans; Immunosuppressive Agents; Indomethacin; Kidney; Mercaptopurine; Middle Aged; Peritoneal Dialysis; Potassium; Prednisone; Prognosis; Proteinuria; Seizures; Time Factors

1969
Use of human lymphocytes in studies of drug action.
    Nature, 1967, Jul-29, Volume: 215, Issue:5100

    Topics: Azathioprine; Benzoates; Chlorambucil; Chloramphenicol; Cyclophosphamide; Dactinomycin; Hydrocortisone; Indomethacin; Lectins; Lymphocytes; Mercaptopurine; Protein Biosynthesis; Puromycin; Salicylates

1967
Effect of chlorambucil and indomethacin on growth and prostaglandin levels in sensitive and resistant Walker carcinoma.
    Chemico-biological interactions, 1982, Mar-15, Volume: 39, Issue:2

    Topics: Animals; Carcinoma 256, Walker; Cell Division; Chlorambucil; Dinoprostone; Dose-Response Relationship, Drug; Drug Resistance; Indomethacin; Mice; Prostaglandins; Prostaglandins E

1982
Interactions of cytotoxic and anti-inflammatory agents on normal and neoplastic tissue.
    Advances in prostaglandin and thromboxane research, 1980, Volume: 6

    Topics: Animals; Carcinoma 256, Walker; Cell Survival; Chlorambucil; Flurbiprofen; Hematopoietic Stem Cells; Indomethacin; Melphalan; Mice; Propionates

1980
Multidrug resistance protein-6 (MRP6) in human dermal fibroblasts. Comparison between cells from normal subjects and from Pseudoxanthoma elasticum patients.
    Matrix biology : journal of the International Society for Matrix Biology, 2003, Volume: 22, Issue:6

    Topics: Adult; Benzbromarone; Cell Count; Cell Division; Chlorambucil; Female; Fibroblasts; Fluoresceins; Fluorescent Dyes; Humans; Indomethacin; Lysosomes; Male; Membrane Transport Proteins; Microscopy, Fluorescence; Middle Aged; Multidrug Resistance-Associated Proteins; Propionates; Pseudoxanthoma Elasticum; Quinolines; Skin; Verapamil; Vinblastine

2003
Multilayer nanoparticles with a magnetite core and a polycation inner shell as pH-responsive carriers for drug delivery.
    Nanoscale, 2010, Volume: 2, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Alkylating; Cells, Cultured; Chlorambucil; Drug Carriers; Ferrosoferric Oxide; Hydrogen-Ion Concentration; Indomethacin; Magnetics; Mice; Nanoparticles; Polymers

2010