indole has been researched along with pyrimidine in 9 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kaur, P; Kaur, S; Kumar, S; Luxami, V; Singh, P | 1 |
| Kaur, M; Sachdeva, S; Singh, P | 1 |
| Chen, YL; Hocek, M; Pohl, R; Shi, PY; Tichý, M; Xu, HY; Yokokawa, F | 1 |
| Devambatla, RK; Dybdal-Hargreaves, NF; Gangjee, A; Hamel, E; Mooberry, SL; Raghavan, S; Westbrook, CD; Zaware, N | 1 |
| Kim, D; Kwon, A; Lee, BY; Min, KH; Nguyen, HK; Song, J; Suh, W; Yoo, J | 1 |
| Cen, L; Gao, X; Li, F; Wen, R; Yan, H; Yao, H; Zhu, S | 1 |
| Jaswal, S; Kumar, S; Monga, V; Rulhania, S | 1 |
| Chen, C; Fang, L; Li, Z; Liu, Q; Luo, Y | 1 |
| Lamie, PF; Philoppes, JN | 1 |
1 review(s) available for indole and pyrimidine
| Article | Year |
|---|---|
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors.
Topics: Acetazolamide; Animals; Antineoplastic Agents; Antioxidants; Benzenesulfonamides; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Humans; Indoles; Isatin; Molecular Docking Simulation; Organoselenium Compounds; Oxadiazoles; Protein Binding; Protein Isoforms; Pyrimidines; Structure-Activity Relationship; Sulfonamides; Thiazines; Thiophenes; Urea | 2021 |
8 other study(ies) available for indole and pyrimidine
| Article | Year |
|---|---|
Syntheses and anti-cancer activities of 2-[1-(indol-3-yl-/pyrimidin-5-yl-/pyridine-2-yl-/quinolin-2-yl)-but-3-enylamino]-2-phenyl-ethanols.
Topics: Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Structure; Neoplasms; Pyridines; Pyrimidines; Quinolines; Structure-Activity Relationship; Tumor Cells, Cultured | 2007 |
Mechanism inspired development of rationally designed dihydrofolate reductase inhibitors as anticancer agents.
Topics: Antineoplastic Agents; Benzaldehydes; Cell Line, Tumor; Drug Design; Folic Acid Antagonists; Humans; Indoles; Models, Molecular; Protein Conformation; Pyrimidines; Tetrahydrofolate Dehydrogenase | 2012 |
Synthesis and antiviral activity of 4,6-disubstituted pyrimido[4,5-b]indole ribonucleosides.
Topics: Antiviral Agents; Catalysis; Cell Line, Tumor; Cell Proliferation; Dengue Virus; Hep G2 Cells; Hepacivirus; Humans; Indoles; Palladium; Pyrimidines; Ribonucleosides; Virus Replication | 2012 |
Synthesis of N(4)-(substituted phenyl)-N(4)-alkyl/desalkyl-9H-pyrimido[4,5-b]indole-2,4-diamines and identification of new microtubule disrupting compounds that are effective against multidrug resistant cells.
Topics: Aniline Compounds; Binding Sites; Cell Line, Tumor; Cell Proliferation; Colchicine; Cyclization; Cyclohexanones; Diamines; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Indoles; Microtubules; Molecular Docking Simulation; Oxidation-Reduction; Protein Binding; Protein Structure, Tertiary; Pyrimidines; Tubulin Modulators | 2013 |
Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases.
Topics: Angiogenesis Inhibitors; Carcinoma, Non-Small-Cell Lung; Cell Proliferation; ErbB Receptors; Human Umbilical Vein Endothelial Cells; Humans; Indazoles; Indoles; Inhibitory Concentration 50; Lung Neoplasms; Molecular Docking Simulation; Neovascularization, Pathologic; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Structure-Activity Relationship; Sulfonamides; Vascular Endothelial Growth Factor A | 2015 |
Oral administration of indole substituted dipyrido[2,3-d]pyrimidine derivative exhibits anti-tumor activity via inhibiting AKT and ERK1/2 on hepatocellular carcinoma.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cell Survival; Female; Hep G2 Cells; Humans; Indoles; Liver Neoplasms; MAP Kinase Signaling System; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Proto-Oncogene Proteins c-akt; Pyrimidines; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
Structural modifications on indole and pyrimidine rings of osimertinib lead to high selectivity towards L858R/T790M double mutant enzyme and potent antitumor activity.
Topics: Acrylamides; Aniline Compounds; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; ErbB Receptors; Humans; Indoles; Molecular Docking Simulation; Molecular Structure; Mutation; Protein Kinase Inhibitors; Pyrimidines; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
Design, synthesis, stereochemical determination, molecular docking study, in silico pre-ADMET prediction and anti-proliferative activities of indole-pyrimidine derivatives as Mcl-1 inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Docking Simulation; Molecular Structure; Myeloid Cell Leukemia Sequence 1 Protein; Pyrimidines; Stereoisomerism; Structure-Activity Relationship | 2021 |