indirubin has been researched along with indirubin-3'-monoxime in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 5 (23.81) | 2.80 |
| Authors | Studies |
|---|---|
| Greengard, P; Leost, M; Magiatis, P; Meijer, L; Mikros, E; Musacchio, A; Myrianthopoulos, V; Pearl, L; Polychronopoulos, P; Roe, SM; Skaltsounis, AL; Tarricone, A | 1 |
| Chung, HJ; Hong, JY; Kim, YC; Lee, JW; Lee, SK; Min, HY; Moon, MJ; Park, EJ; Park, HJ | 1 |
| Bettayeb, K; Ferandin, Y; Kritsanida, M; Lozach, O; Magiatis, P; Meijer, L; Polychronopoulos, P; Skaltsounis, AL | 1 |
| Grundt, P; Jones-Brando, L; Krivogorsky, B; Yolken, R | 1 |
| Choi, SJ; Choi, SU; Han, SY; Kim, YC; Lee, SD; Moon, MJ | 1 |
| Hanada, S; Kanda, Y; Miyairi, S; Saito, H; Suzuki, T; Tabata, K | 1 |
| Ichimaru, Y; Metori, K; Miyairi, S; Saito, H; Suzuki, T; Tabata, K; Uchiyama, T | 1 |
| Evdokimov, NM; Kornienko, A; Magedov, IV; McBrayer, D | 1 |
| Byun, BJ; Choi, G; Choi, SU; Jung, ME; Kim, HM; Kim, SJ; Kim, YC; Lee, JY; Lee, K; Lee, N; Park, JH; Son, YH; Yang, KM | 1 |
| Gaboriaud-Kolar, N; Gerolymatos, P; Horne, DA; Jove, R; Mikros, E; Myrianthopoulos, V; Nam, S; Skaltsounis, AL; Vougogiannopoulou, K | 1 |
| Cheng, X; Christ, J; Eisenbrand, G; Merz, KH; Muehlbeyer, S; Thommet, A; Vatter, S; Wölfl, S; Zeller, J | 1 |
| Haraguchi, T; Ichimaru, Y; Ishige, K; Ito, Y; Kobayashi, S; Kosuge, Y; Miyagishi, H; Miyairi, S; Ohashi, S; Saito, H | 1 |
| Bai, G; Chen, Y; Wang, H; Wang, J; Wang, Z; Wei, C; Xu, Y; Yao, Q; Zhang, L | 1 |
| Bradfield, CA; Glover, E; Martin, MV; McCormick, WA; Nguyen, LP; Peter Guengerich, F | 1 |
| Aiyejorun, T; Baranowski, TC; Blavo, D; Dingledine, R; Doan, TN; Haider, J; Rubinstein, AL; Sandberg, EM; Sneed, B; Tran, TC; White, A | 1 |
| Duarte, FV; Gomes, AP; Palmeira, CM; Rolo, AP; Teodoro, JS; Varela, AT | 1 |
| Abdalsamad, MR; C Chandramoorthy, H; Dera, A; Rajagopalan, P | 1 |
| Kishikawa, Y; Miyairi, S; Nobushi, Y; Saito, H; Uchiyama, T | 1 |
| Boeckmann, L; Emmert, S; Fischle, A; Hein, M; Hinz, B; Kordt, M; Langer, P; Ramer, R; Schwarz, R; Vollmar, B; Wendt, F | 1 |
| Jiang, C; Qi, L; Wang, Y; Xue, J | 1 |
| Chen, X; Chen, Y; Cui, N; Kong, L; Li, S; Li, X; Luo, H; Luo, Z; Wan, S; Wang, X; Yin, F; Zhang, Y | 1 |
1 review(s) available for indirubin and indirubin-3'-monoxime
| Article | Year |
|---|---|
Anticancer potential of indirubins in medicinal chemistry: Biological activity, structural modification, and structure-activity relationship.
Topics: Antineoplastic Agents; Cell Survival; Chemistry, Pharmaceutical; Drugs, Chinese Herbal; Humans; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Oximes; Structure-Activity Relationship | 2021 |
20 other study(ies) available for indirubin and indirubin-3'-monoxime
| Article | Year |
|---|---|
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Topics: Cyclin-Dependent Kinases; Glycogen Synthase Kinase 3; Indoles; Models, Molecular; Oximes; Structure-Activity Relationship | 2004 |
Induction of apoptosis by a novel indirubin-5-nitro-3'-monoxime, a CDK inhibitor, in human lung cancer cells.
Topics: Antibiotics, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinases; Humans; Indoles; Interphase; Lung Neoplasms; Structure-Activity Relationship | 2005 |
3'-Substituted 7-halogenoindirubins, a new class of cell death inducing agents.
Topics: Antineoplastic Agents; Bromine; Cell Death; Cell Line, Tumor; Chlorine; Drug Screening Assays, Antitumor; Fluorine; Humans; Indoles; Iodine; Models, Molecular; Stereoisomerism; Structure-Activity Relationship | 2006 |
Inhibition of Toxoplasma gondii by indirubin and tryptanthrin analogs.
Topics: Animals; Antiprotozoal Agents; Drugs, Chinese Herbal; Indoles; Isatis; Parasitic Sensitivity Tests; Quinazolines; Toxoplasma | 2008 |
Indirubin derivatives as potent FLT3 inhibitors with anti-proliferative activity of acute myeloid leukemic cells.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Humans; Indoles; Leukemia, Myeloid, Acute | 2010 |
Synthesis of methoxy- and bromo-substituted indirubins and their activities on apoptosis induction in human neuroblastoma cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Chemistry Techniques, Synthetic; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Indoles; Molecular Structure; Neuroblastoma; Stereoisomerism; Structure-Activity Relationship | 2011 |
Indirubin 3'-(O-oxiran-2-ylmethyl)oxime: a novel anticancer agent.
Topics: Antineoplastic Agents; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Indoles; Molecular Structure; Oximes; Structure-Activity Relationship | 2015 |
Isatin derivatives with activity against apoptosis-resistant cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isatin; Molecular Structure; Neoplasms; Structure-Activity Relationship | 2016 |
Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening.
Topics: Apoptosis Regulatory Proteins; Dose-Response Relationship, Drug; Drug Discovery; High-Throughput Screening Assays; Humans; Indoles; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Structure-Activity Relationship | 2016 |
Natural-Based Indirubins Display Potent Cytotoxicity toward Wild-Type and T315I-Resistant Leukemia Cell Lines.
Topics: Apoptosis; Benzamides; Cell Line, Tumor; Cell Survival; Crystallography, X-Ray; CSK Tyrosine-Protein Kinase; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Structure; Piperazines; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases | 2016 |
Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Screening Assays, Antitumor; Humans; Indoles; Oximes; Protein Kinase Inhibitors; Receptor, IGF Type 1; Signal Transduction; Solubility; Structure-Activity Relationship | 2017 |
Indirubin derivatives protect against endoplasmic reticulum stress-induced cytotoxicity and down-regulate CHOP levels in HT22 cells.
Topics: Animals; Apoptosis; Cell Line; Down-Regulation; Endoplasmic Reticulum Stress; Indoles; Mice; Protective Agents; Structure-Activity Relationship; Transcription Factor CHOP; Tunicamycin | 2017 |
Aryl hydrocarbon receptor response to indigoids in vitro and in vivo.
Topics: Animals; Binding, Competitive; Cell Line, Tumor; Cytochrome P-450 CYP1A1; Cytosol; Dioxins; Humans; Indigo Carmine; Indoles; Luciferases; Male; Mice; Microsomes, Liver; Oxidation-Reduction; Oximes; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Aryl Hydrocarbon; Response Elements; Transfection | 2004 |
Automated, quantitative screening assay for antiangiogenic compounds using transgenic zebrafish.
Topics: Algorithms; Angiogenesis Inhibitors; Animals; Animals, Genetically Modified; Automation; Blood Vessels; Cell Movement; Cell Proliferation; Drug Evaluation, Preclinical; Embryo, Nonmammalian; Endothelium, Vascular; Humans; Indoles; Neovascularization, Physiologic; Oximes; Thymidine; Umbilical Veins; Zebrafish | 2007 |
Indirubin and NAD
Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Calcium; Cyclophilins; Cytochromes c; Fatty Liver; Glycogen Synthase Kinase 3 beta; Hepatic Artery; Indoles; Liver; Mitochondria, Liver; Mitochondrial ADP, ATP Translocases; NAD; Oximes; Peptidyl-Prolyl Isomerase F; Rats; Rats, Zucker; Reactive Oxygen Species; Reperfusion Injury; Sirtuins; Warm Ischemia | 2018 |
Rational combinations of indirubin and arylidene derivatives exhibit synergism in human non-small cell lung carcinoma cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Benzylidene Compounds; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Humans; Indans; Indoles; Lung Neoplasms; Neoplasm Metastasis; Oximes; Proto-Oncogene Proteins c-bcl-2 | 2019 |
Inhibitory Effects of Indirubin-3'-oxime Derivatives on Lipid Accumulation in 3T3-L1 Cells.
Topics: 3T3-L1 Cells; Adipocytes; Animals; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Survival; Indoles; Lipid Metabolism; Mice; Oximes; Plant Extracts | 2020 |
A Sensitive LC-MS/MS Method for the Simultaneous Determination of Two Thia-Analogous Indirubin
Topics: Animals; Antineoplastic Agents; Cell Culture Techniques; Chromatography, Liquid; Glycosides; Humans; Indoles; Mice; Oximes; Oxindoles; Reproducibility of Results; Tandem Mass Spectrometry | 2022 |
Indirubin-3'-oxime promotes the efficacy of GnRHa in obese-induced central precocious puberty and maintains normal bone growth and body weight via the ERK-Sp1-KISS-1/GPR54 axis.
Topics: Animals; Body Weight; Bone Development; Female; Kisspeptins; Mice; Mice, Inbred C57BL; Obesity; Oximes | 2023 |
Indirubin derivatives as bifunctional molecules inducing DNA damage and targeting PARP for the treatment of cancer.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; DNA Damage; Neoplasms; Phthalazines; Poly(ADP-ribose) Polymerase Inhibitors | 2023 |