indigo-carmine and tris(2-carboxyethyl)phosphine

indigo-carmine has been researched along with tris(2-carboxyethyl)phosphine* in 1 studies

Other Studies

1 other study(ies) available for indigo-carmine and tris(2-carboxyethyl)phosphine

Article	Year
Synthesis of hemithioindigo-based chromopeptides by using the Tmb auxiliary in native chemical ligation studies. Journal of peptide science : an official publication of the European Peptide Society, 2017, Volume: 23, Issue:7-8 The 4,5,6-trimethoxy-2-mercaptobenzyl auxiliary was used in auxiliary-based native chemical ligation reactions with Boc-protected pHTI and mHTI ω-amino acid thioesters 2a,b for the construction of small hemithioindigo (HTI)-based chromopeptides 6a,b with a class 1 PDZ binding motif. While reversible tris(2-carboxyethyl)phosphine (TCEP)-HTI adduct formation required moderate use of access TCEP, the Na ascorbate concentration was broadly varied for optimization of the reaction conditions. In the studies presented, the mHTI ω-amino acid thioester 2b proved to be slightly less reactive than the pHTI ω-amino acid thioester 2a. Ligated products 5a-d were isolated in 35-81% yield, and also cleavage of the auxiliary proceeded smoothly, furnishing peptides 6a-d in 48-61% yield. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd. Topics: Cysteine; Indigo Carmine; Peptides; Phosphines	2017

Article

Year

Synthesis of hemithioindigo-based chromopeptides by using the Tmb auxiliary in native chemical ligation studies.

Journal of peptide science : an official publication of the European Peptide Society, 2017, Volume: 23, Issue:7-8

The 4,5,6-trimethoxy-2-mercaptobenzyl auxiliary was used in auxiliary-based native chemical ligation reactions with Boc-protected pHTI and mHTI ω-amino acid thioesters 2a,b for the construction of small hemithioindigo (HTI)-based chromopeptides 6a,b with a class 1 PDZ binding motif. While reversible tris(2-carboxyethyl)phosphine (TCEP)-HTI adduct formation required moderate use of access TCEP, the Na ascorbate concentration was broadly varied for optimization of the reaction conditions. In the studies presented, the mHTI ω-amino acid thioester 2b proved to be slightly less reactive than the pHTI ω-amino acid thioester 2a. Ligated products 5a-d were isolated in 35-81% yield, and also cleavage of the auxiliary proceeded smoothly, furnishing peptides 6a-d in 48-61% yield. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.

Topics: Cysteine; Indigo Carmine; Peptides; Phosphines

2017