indazoles has been researched along with sch772984 in 36 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 28 (77.78) | 24.3611 |
| 2020's | 8 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Nissan, MH; Rosen, N; Solit, DB | 1 |
| Atefi, MS; Avarappatt, G; Avramis, E; Cerniglia, M; Comin-Anduix, B; Foulad, D; Graeber, TG; Lassen, A; Lo, RS; Ribas, A; Robert, L; Samatar, A; Tsoi, J; Wong, DJ | 1 |
| Foda, ZH; Seeliger, MA | 1 |
| Chaikuad, A; Gray, NS; Knapp, S; Liang, Y; Tacconi, EM; Tarsounas, M; Zimmer, J | 1 |
| Altelaar, AF; Cappadona, S; Greig, K; Heck, AJ; Maddalo, G; Peeper, DS; Possik, PA; Raaijmakers, LM; Smit, MA; van Breukelen, B | 1 |
| Cox, AD; Der, CJ; Finn, AJ; Pedone, KH; Ryan, MB; Thomas, NE | 1 |
| Brafford, P; Chen, HY; Chen, T; Davies, MA; Fukunaga-Kalabis, M; Halloran, M; He, X; Herlyn, M; Hristova, D; Krepler, C; Liu, Q; Nathanson, KL; Reyes-Uribe, PI; Samanta, M; Samatar, AA; Villanueva, J; Vultur, A; Xiao, M | 1 |
| Cantley, LC; Chen, S; Manstein, D; Merghoub, T; Mu, C; Ran, Y; Rosen, N; Shakuntala, T; Shaw, FM; Trousil, S; Yao, Z; Zheng, B; Zippin, JH | 1 |
| Gao, C; Gao, L; Luo, X; Yan, J; Zhao, C; Zhao, J; Zhao, W; Zhu, X | 1 |
| Carné, X; Fernández-Albert, J; Sindreu, C; Storm, DR; Zamorano, C | 1 |
| Chang, G; Chang, S; Chen, G; Dai, B; Gao, L; Hu, L; Li, B; Shi, J; Sun, X; Xiao, W; Xie, B; Xie, Y; Xu, Z; Yu, D; Zhang, Y; Zhu, W | 1 |
| Beckedorff, F; Lai, F; Pastori, C; Shiekhattar, R; Yue, J; Zhang, A | 1 |
| Bellio, M; Buratto, M; Chiara Zatelli, M; Degli Uberti, E; Di Pasquale, C; Falletta, S; Gentilin, E | 1 |
| Liu, X; Ruan, X; Song, J; Wang, W; Wei, X; Xu, X; Ying, Y | 1 |
| Dang, KX; Haglund, C; Ho, TH; Koistinen, H; Lintula, S; Mustonen, H; Räsänen, K; Stenman, J; Stenman, UH | 1 |
| Ahn, NG; Basken, J; Ebmeier, CC; Kavran, AJ; Lee, T; Old, WM; Stuart, SA | 1 |
| Basaga, H; Gul, O; Karakas, B; Kutuk, O; Ozmay, Y | 1 |
| Cheng, L; Li, X; Yang, F; Zhang, L | 1 |
| Bai, C; Gao, Y; Ma, L; Yang, W; Zhang, X | 1 |
| Gao, H; Guo, X; Li, X; Liu, N; Peng, S; Wang, K; Wu, W; Yu, J; Zhan, G; Zhu, Y | 1 |
| Chen, H; Cheng, J; Duan, J; Geng, G; He, H; Hua, R; Jiang, X; Li, Q; Li, X; Li, Y; Liu, D; Wu, L; Xu, D; Yang, L | 1 |
| Novák, P; Nováková, J; Talacko, P; Vališ, K | 1 |
| Arellano-Sánchez, N; Benito-Jardón, L; Díaz-Martínez, M; Esparís-Ogando, A; Teixidó, J; Vaquero-Morales, P | 1 |
| Abe, T; Ando, Y; Fei, S; Feng, H; Guan, W; Hashizume, M; Iwamoto, C; Kibe, S; Koikawa, K; Miyasaka, Y; Mizumoto, K; Moriyama, T; Nakamura, M; Nakata, K; Ohtsuka, T; Ohuchida, K; Shindo, K; Yan, Z; Zheng, B | 1 |
| Lu, L; Wang, QC; Zhou, HJ | 1 |
| Näär, AM; Wu, S | 1 |
| Creixell, P; Jeschke, GR; Kim, J; Linding, R; Longden, J; Poulikakos, PI; Rosen, N; Santini, CC; Schoof, EM; Simpson, CD; Turk, BE; Wu, X | 1 |
| Kubo, S; Matsui, T; Nakayamada, S; Okada, Y; Sakata, K; Tanaka, K; Tanaka, Y; Yamagata, K; Yamagishi, SI | 1 |
| Zhai, H; Zhang, Y | 1 |
| Bai, Y; Baker, PN; Chen, X; Gao, R; Hu, M; Kilby, MD; Liu, Y; Luo, X; Peng, W; Qi, H; Saffery, R; Tan, B; Tong, C; Wang, H; Wen, L; Wu, Y; Xu, P; Yang, Y | 1 |
| Baltes, F; Bendas, G; Caspers, J; Henze, S; Schlesinger, M | 1 |
| E Schweppe, R; Espinoza, VL; Hicks, HM; LaBarbera, D; McKenna, LR; Pike, LA; Pozdeyev, N; Raeburn, CD; Reigan, P; Sams, SB | 1 |
| Bin, L; Furukawa, T; Gazi, MY; Hatsuzawa, Y; Ito, S; Kajiwara, T; Kamei, T; Karasawa, H; Katsuoka, F; Kobayashi, M; Kumada, K; Ohnuma, S; Okamura, Y; Sato, M; Shiihara, M; Shimada, M; Suzuki, H; Tayama, H; Unno, M; Yamamura, A | 1 |
| Bomsztyk, K; Goryca, K; Kopczynski, M; Kulecka, M; Majewska, E; Masiejczyk, M; Mikula, M; Ostrowski, J; Pysniak, K; Pyziak, K; Rumienczyk, I; Rzymski, T; Sandowska-Markiewicz, Z; Statkiewicz, M; Wojcik-Jaszczynska, K; Wojcik-Trechcinska, U | 1 |
| Chen, J; He, P; Tian, M; Yu, R; Zhang, B; Zhang, Y; Zhao, Z | 1 |
| Buzdin, AA; Ivanenko, KA; Khabusheva, ER; Kudryavtseva, AV; Lebedev, TD; Mareeva, SR; Morozov, AV; Prassolov, VS; Rubtsov, PM; Snezhkina, AV; Sorokin, MI; Spirin, PV | 1 |
36 other study(ies) available for indazoles and sch772984
| Article | Year |
|---|---|
ERK pathway inhibitors: how low should we go?
Topics: Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Humans; Imidazoles; Indazoles; Indoles; MAP Kinase Signaling System; Neoplasms; Oximes; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Sulfonamides; Vemurafenib | 2013 |
Antitumor activity of the ERK inhibitor SCH772984 [corrected] against BRAF mutant, NRAS mutant and wild-type melanoma.
Topics: Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; GTP Phosphohydrolases; Humans; Indazoles; Indoles; Inhibitory Concentration 50; Membrane Proteins; Molecular Targeted Therapy; Multiple Myeloma; Mutation; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Sulfonamides; Vemurafenib | 2014 |
Kinase inhibitors: an allosteric add-on.
Topics: Antineoplastic Agents; Enzyme Inhibitors; Humans; Indazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Piperazines | 2014 |
A unique inhibitor binding site in ERK1/2 is associated with slow binding kinetics.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Intracellular Signaling Peptides and Proteins; Kinetics; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Piperazines; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins | 2014 |
ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma.
Topics: Cell Line, Tumor; Chromatography, Liquid; Down-Regulation; Forkhead Transcription Factors; Humans; Indazoles; Indoles; Melanoma; Molecular Targeted Therapy; Mutation; Piperazines; Proteomics; Proto-Oncogene Proteins B-raf; Receptor, ErbB-3; rho-Associated Kinases; RNA Interference; RNA, Small Interfering; Sulfonamides; Tandem Mass Spectrometry; Vemurafenib | 2014 |
ERK/MAPK Signaling Drives Overexpression of the Rac-GEF, PREX1, in BRAF- and NRAS-Mutant Melanoma.
Topics: Animals; Cell Line, Tumor; Cell Movement; Female; Gene Expression Regulation, Neoplastic; GTP Phosphohydrolases; Guanine Nucleotide Exchange Factors; Humans; Indazoles; Indoles; Male; MAP Kinase Signaling System; Melanoma; Membrane Proteins; Mice; Mutation; Piperazines; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Sulfonamides; Up-Regulation; Vemurafenib | 2016 |
Targeting Notch enhances the efficacy of ERK inhibitors in BRAF-V600E melanoma.
Topics: Amyloid Precursor Protein Secretases; Animals; Cell Line, Tumor; Extracellular Signal-Regulated MAP Kinases; Humans; Indazoles; Melanoma; Mice; Phosphatidylinositol 3-Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; PTEN Phosphohydrolase; Receptors, Notch | 2016 |
Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma.
Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Drug Synergism; Extracellular Signal-Regulated MAP Kinases; Humans; Indazoles; Melanoma; Mutation; Neurofibromin 1; Oxygen Consumption; Phenformin; Piperazines | 2017 |
Cdk5 is required for the neuroprotective effect of transforming growth factor-β1 against cerebral ischemia-reperfusion.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Brain Ischemia; Cell Differentiation; Cell Proliferation; Cyclin-Dependent Kinase 5; Indazoles; MAP Kinase Signaling System; Neurites; Neuroprotective Agents; PC12 Cells; Piperazines; Protein Kinase Inhibitors; Purines; Rats; Reperfusion Injury; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Roscovitine; Transforming Growth Factor beta1 | 2017 |
Memory Retrieval Re-Activates Erk1/2 Signaling in the Same Set of CA1 Neurons Recruited During Conditioning.
Topics: Animals; CA1 Region, Hippocampal; Cells, Cultured; Conditioning, Psychological; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Fear; Indazoles; Memory, Long-Term; Mental Recall; Mice, Inbred C57BL; Mice, Transgenic; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neurons; Piperazines | 2018 |
Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway.
Topics: Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Proliferation; Humans; Indazoles; Jurkat Cells; Leukemia, T-Cell; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Phosphorylation; Piperazines; Reactive Oxygen Species; Stilbenes | 2017 |
Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs.
Topics: A549 Cells; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Chromatin; Endoribonucleases; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Knockdown Techniques; Humans; Indazoles; MAP Kinase Signaling System; Neoplasms; Phosphorylation; Piperazines; Promoter Regions, Genetic; Protein Transport; ras Proteins; Signal Transduction | 2017 |
PI3K/Akt/mTOR pathway involvement in regulating growth hormone secretion in a rat pituitary adenoma cell line.
Topics: Adenoma; Animals; Cell Line, Tumor; Everolimus; Feedback, Physiological; Growth Hormone; Imidazoles; Indazoles; Insulin-Like Growth Factor I; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperazines; Pituitary Neoplasms; Proto-Oncogene Proteins c-akt; Quinolines; Rats; Signal Transduction; TOR Serine-Threonine Kinases | 2018 |
The role of P2X7R/ERK signaling in dorsal root ganglia satellite glial cells in the development of chronic postsurgical pain induced by skin/muscle incision and retraction (SMIR).
Topics: Animals; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Hyperalgesia; Indazoles; Male; Models, Animal; Pain Measurement; Pain, Postoperative; Phosphorylation; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X7; Rosaniline Dyes; Satellite Cells, Perineuronal; Signal Transduction; Surgical Wound | 2018 |
MAPK inhibitors induce serine peptidase inhibitor Kazal type 1 (SPINK1) secretion in BRAF V600E-mutant colorectal adenocarcinoma.
Topics: Activating Transcription Factor 4; Adenocarcinoma; Aged; Caco-2 Cells; Cell Line, Tumor; Cohort Studies; Colorectal Neoplasms; Female; HT29 Cells; Humans; Indazoles; Male; Middle Aged; Mitogen-Activated Protein Kinases; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Trypsin Inhibitor, Kazal Pancreatic | 2018 |
Specificity of Phosphorylation Responses to Mitogen Activated Protein (MAP) Kinase Pathway Inhibitors in Melanoma Cells.
Topics: Cell Line, Tumor; Humans; Indazoles; Melanoma; Mitogen-Activated Protein Kinases; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Signal Transduction | 2018 |
Distinct apoptotic blocks mediate resistance to panHER inhibitors in HER2+ breast cancer cells.
Topics: bcl-X Protein; Benzothiazoles; Biphenyl Compounds; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Isoquinolines; Nitrophenols; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Quinazolinones; Quinolines; Receptor, ErbB-2; Sulfonamides | 2018 |
LncRNA TUG1 promoted viability and associated with gemcitabine resistant in pancreatic ductal adenocarcinoma.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Pancreatic Ductal; Cell Movement; Cell Survival; Cells, Cultured; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression; Humans; Indazoles; Neoplasm Invasiveness; Pancreatic Neoplasms; Piperazines; RNA, Long Noncoding | 2018 |
Melatonin promotes self-renewal and nestin expression in neural stem cells from the retina.
Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Dioxoles; Extracellular Signal-Regulated MAP Kinases; Gene Expression Profiling; Indazoles; MAP Kinase Signaling System; Melatonin; Mice; Nestin; Neural Stem Cells; Piperazines; Receptor, Melatonin, MT1; Retina; RNA Interference; Smad4 Protein; Transforming Growth Factor beta | 2019 |
β-hCG promotes epithelial ovarian cancer metastasis through ERK/MMP2 signaling pathway.
Topics: Animals; Apoptosis; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chorionic Gonadotropin, beta Subunit, Human; Female; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Indazoles; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Piperazines; Receptors, LH | 2019 |
Raf-ERK1/2 signalling pathways mediate steroid hormone synthesis in bovine ovarian granulosa cells.
Topics: Animals; Cattle; Cells, Cultured; Estradiol; Female; Gene Expression; Granulosa Cells; Imidazoles; Indazoles; MAP Kinase Signaling System; Oximes; Piperazines; Progesterone; RNA, Messenger; Testosterone | 2019 |
The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells.
Topics: Amino Acid Sequence; Apoptosis; Caspase Inhibitors; Caspases; Down-Regulation; Enzyme Activation; Hepatocyte Growth Factor; Humans; Indazoles; Jurkat Cells; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Models, Biological; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Phosphothreonine; Piperazines; Proteolysis; Proto-Oncogene Proteins; Sulfonamides | 2019 |
Resistance to MAPK Inhibitors in Melanoma Involves Activation of the IGF1R-MEK5-Erk5 Pathway.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Indazoles; MAP Kinase Kinase 5; MAP Kinase Signaling System; Melanoma; Mice; Mice, Inbred NOD; Mice, SCID; Mitogen-Activated Protein Kinase 7; Piperazines; Receptor, IGF Type 1; Signal Transduction; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2019 |
Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.
Topics: Animals; Autophagy; Carcinoma, Pancreatic Ductal; Cell Communication; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chloroquine; Drug Synergism; Epithelial-Mesenchymal Transition; Humans; Indazoles; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neoplasm Metastasis; Pancreatic Neoplasms; Pancreatic Stellate Cells; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Stromal Cells; Xenograft Model Antitumor Assays | 2019 |
Relationship between the MAPK/ERK pathway and neurocyte apoptosis after cerebral infarction in rats.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cerebral Infarction; Disease Models, Animal; Humans; Indazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nestin; Neural Stem Cells; Neurons; Piperazines; Primary Cell Culture; Rats | 2019 |
SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait.
Topics: Cell Line, Tumor; Cell Survival; Extracellular Signal-Regulated MAP Kinases; Fatty Acids; Gene Expression Regulation, Neoplastic; Humans; Indazoles; Kaplan-Meier Estimate; Melanoma; Neoplasm Proteins; Neoplasms; Piperazines; Prognosis; Proto-Oncogene Proteins B-raf; RNA Interference; RNA Polymerase II; RNA, Small Interfering; Skin Neoplasms; Sterol Regulatory Element Binding Protein 1; Transcription, Genetic; Vemurafenib | 2019 |
Global view of the RAF-MEK-ERK module and its immediate downstream effectors.
Topics: Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Humans; Imidazoles; Indazoles; MAP Kinase Signaling System; Melanoma; Mitogen-Activated Protein Kinase Kinases; Oximes; Phosphorylation; Piperazines; Proteome; Proteomics; Proto-Oncogene Proteins B-raf; Pyridones; Pyrimidinones; Skin Neoplasms | 2019 |
Glycolaldehyde-modified advanced glycation end-products inhibit differentiation of human monocytes into osteoclasts via upregulation of IL-10.
Topics: Antibodies, Neutralizing; Cathepsin K; Cells, Cultured; Glycation End Products, Advanced; Humans; Immunoblotting; Indazoles; Interleukin-10; Lipopolysaccharide Receptors; Monocytes; NFATC Transcription Factors; Nitriles; Osteoclasts; Osteogenesis; Piperazines; RNA, Messenger; Serum Albumin, Bovine; Sulfones | 2019 |
Bilobalide assuages morphine-induced addiction in hippocampal neuron cells through upregulation of microRNA-101.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Hippocampus; Indazoles; MAP Kinase Signaling System; MicroRNAs; Morphine; Neurons; Orexin Receptors; Oxaliplatin; Piperazines; Plant Extracts; Protein Kinase C; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Transfection; Up-Regulation | 2020 |
Phosphorylation of Yes-associated protein impairs trophoblast invasion and migration: implications for the pathogenesis of fetal growth restriction†.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cell Line; Cell Movement; Embryo, Mammalian; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation; Humans; Indazoles; Mice; Mice, Inbred C57BL; Phosphorylation; Piperazines; Placenta; Pregnancy; Transcription Factors; Trophoblasts; Up-Regulation; YAP-Signaling Proteins | 2020 |
Targeting Discoidin Domain Receptor 1 (DDR1) Signaling and Its Crosstalk with β
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; Breast Neoplasms; Cell Adhesion; Cell Line, Tumor; Collagen Type I; Discoidin Domain Receptor 1; Doxorubicin; Drug Resistance, Neoplasm; ErbB Receptors; Focal Adhesion Kinase 1; Gefitinib; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Indazoles; Integrin beta1; Integrin beta4; MAP Kinase Signaling System; MCF-7 Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitoxantrone; Neoplasm Proteins; Piperazines; Tumor Microenvironment | 2020 |
Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; Imidazoles; Indazoles; MAP Kinase Signaling System; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mutation; Oximes; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Thyroid Neoplasms; Xenograft Model Antitumor Assays | 2021 |
The association between ERK inhibitor sensitivity and molecular characteristics in colorectal cancer.
Topics: Cell Line, Tumor; Colorectal Neoplasms; Enzyme Inhibitors; Exome Sequencing; Extracellular Signal-Regulated MAP Kinases; High-Throughput Nucleotide Sequencing; Humans; Indazoles; Mutation; Organoids; Piperazines; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras) | 2021 |
Selective Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibition by the SCH772984 Compound Attenuates In Vitro and In Vivo Inflammatory Responses and Prolongs Survival in Murine Sepsis Models.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chemokine CCL2; Disease Models, Animal; Down-Regulation; Drug Repositioning; Endotoxemia; Gene Expression Regulation; Indazoles; Lipopolysaccharides; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Piperazines; Platelet Activation; Pyridines; Pyrrolidines; RAW 264.7 Cells; Transcriptome; Triazoles; Tumor Necrosis Factor-alpha | 2021 |
Suppression of LMCD1 ameliorates renal fibrosis by blocking the activation of ERK pathway.
Topics: Animals; Apoptosis; Cell Line; Co-Repressor Proteins; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Humans; Indazoles; Kidney; LIM Domain Proteins; Male; Mice; Mice, Inbred C57BL; Nephritis, Interstitial; Piperazines; RNA Interference; RNA, Small Interfering; Signal Transduction; Transforming Growth Factor beta1; Up-Regulation; Ureteral Obstruction | 2022 |
Identification of cell type-specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors.
Topics: Aminopyridines; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Cell Survival; Diphenylamine; Humans; Indazoles; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Neuroblastoma; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins p21(ras); Pyrazoles; Pyridones; Pyrimidines; Pyrroles | 2022 |